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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NFIC-MPND (FusionGDB2 ID:58915)

Fusion Gene Summary for NFIC-MPND

check button Fusion gene summary
Fusion gene informationFusion gene name: NFIC-MPND
Fusion gene ID: 58915
HgeneTgene
Gene symbol

NFIC

MPND

Gene ID

4782

84954

Gene namenuclear factor I CMPN domain containing
SynonymsCTF|CTF5|NF-I|NFI-
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear factor 1 C-typeCCAAT-box-binding transcription factorNF-I/CNF1-CTGGCA-binding proteinnuclear factor I/C (CCAAT-binding transcription factor)MPN domain-containing protein
Modification date2020031320200313
UniProtAcc

P08651

Q8N594

Ensembl transtripts involved in fusion geneENST00000341919, ENST00000443272, 
ENST00000590282, ENST00000346156, 
ENST00000395111, ENST00000586919, 
ENST00000588839, ENST00000589123, 
ENST00000262966, ENST00000359935, 
ENST00000599840, 
Fusion gene scores* DoF score30 X 20 X 13=78003 X 2 X 2=12
# samples 363
** MAII scorelog2(36/7800*10)=-4.4374053123073
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NFIC [Title/Abstract] AND MPND [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNFIC(3366664)-MPND(4357250), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFIC

GO:0000122

negative regulation of transcription by RNA polymerase II

19706729

HgeneNFIC

GO:0045944

positive regulation of transcription by RNA polymerase II

1524678|19706729


check buttonFusion gene breakpoints across NFIC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MPND (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-IF-A4AK-01ANFICchr19

3366664

+MPNDchr19

4357250

+


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Fusion Gene ORF analysis for NFIC-MPND

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000341919ENST00000262966NFICchr19

3366664

+MPNDchr19

4357250

+
In-frameENST00000341919ENST00000359935NFICchr19

3366664

+MPNDchr19

4357250

+
In-frameENST00000341919ENST00000599840NFICchr19

3366664

+MPNDchr19

4357250

+
In-frameENST00000443272ENST00000262966NFICchr19

3366664

+MPNDchr19

4357250

+
In-frameENST00000443272ENST00000359935NFICchr19

3366664

+MPNDchr19

4357250

+
In-frameENST00000443272ENST00000599840NFICchr19

3366664

+MPNDchr19

4357250

+
In-frameENST00000590282ENST00000262966NFICchr19

3366664

+MPNDchr19

4357250

+
In-frameENST00000590282ENST00000359935NFICchr19

3366664

+MPNDchr19

4357250

+
In-frameENST00000590282ENST00000599840NFICchr19

3366664

+MPNDchr19

4357250

+
intron-3CDSENST00000346156ENST00000262966NFICchr19

3366664

+MPNDchr19

4357250

+
intron-3CDSENST00000346156ENST00000359935NFICchr19

3366664

+MPNDchr19

4357250

+
intron-3CDSENST00000346156ENST00000599840NFICchr19

3366664

+MPNDchr19

4357250

+
intron-3CDSENST00000395111ENST00000262966NFICchr19

3366664

+MPNDchr19

4357250

+
intron-3CDSENST00000395111ENST00000359935NFICchr19

3366664

+MPNDchr19

4357250

+
intron-3CDSENST00000395111ENST00000599840NFICchr19

3366664

+MPNDchr19

4357250

+
intron-3CDSENST00000586919ENST00000262966NFICchr19

3366664

+MPNDchr19

4357250

+
intron-3CDSENST00000586919ENST00000359935NFICchr19

3366664

+MPNDchr19

4357250

+
intron-3CDSENST00000586919ENST00000599840NFICchr19

3366664

+MPNDchr19

4357250

+
intron-3CDSENST00000588839ENST00000262966NFICchr19

3366664

+MPNDchr19

4357250

+
intron-3CDSENST00000588839ENST00000359935NFICchr19

3366664

+MPNDchr19

4357250

+
intron-3CDSENST00000588839ENST00000599840NFICchr19

3366664

+MPNDchr19

4357250

+
intron-3CDSENST00000589123ENST00000262966NFICchr19

3366664

+MPNDchr19

4357250

+
intron-3CDSENST00000589123ENST00000359935NFICchr19

3366664

+MPNDchr19

4357250

+
intron-3CDSENST00000589123ENST00000599840NFICchr19

3366664

+MPNDchr19

4357250

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000341919NFICchr193366664+ENST00000262966MPNDchr194357250+62211888537149
ENST00000341919NFICchr193366664+ENST00000359935MPNDchr194357250+70711888627179
ENST00000341919NFICchr193366664+ENST00000599840MPNDchr194357250+69811888627179
ENST00000590282NFICchr193366664+ENST00000262966MPNDchr194357250+5888454503149
ENST00000590282NFICchr193366664+ENST00000359935MPNDchr194357250+6738454593179
ENST00000590282NFICchr193366664+ENST00000599840MPNDchr194357250+6648454593179
ENST00000443272NFICchr193366664+ENST00000262966MPNDchr194357250+5858151500149
ENST00000443272NFICchr193366664+ENST00000359935MPNDchr194357250+6708151590179
ENST00000443272NFICchr193366664+ENST00000599840MPNDchr194357250+6618151590179

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000341919ENST00000262966NFICchr193366664+MPNDchr194357250+0.101886270.8981138
ENST00000341919ENST00000359935NFICchr193366664+MPNDchr194357250+0.0132118760.98678815
ENST00000341919ENST00000599840NFICchr193366664+MPNDchr194357250+0.0132438260.9867562
ENST00000590282ENST00000262966NFICchr193366664+MPNDchr194357250+0.0929848250.9070152
ENST00000590282ENST00000359935NFICchr193366664+MPNDchr194357250+0.0149451560.98505485
ENST00000590282ENST00000599840NFICchr193366664+MPNDchr194357250+0.0163047740.98369527
ENST00000443272ENST00000262966NFICchr193366664+MPNDchr194357250+0.083787080.9162129
ENST00000443272ENST00000359935NFICchr193366664+MPNDchr194357250+0.0148227550.9851773
ENST00000443272ENST00000599840NFICchr193366664+MPNDchr194357250+0.0159578640.98404217

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Fusion Genomic Features for NFIC-MPND


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NFICchr193366664+MPNDchr194357249+9.20E-070.99999905
NFICchr193366664+MPNDchr194357249+9.20E-070.99999905

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NFIC-MPND


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:3366664/chr19:4357250)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFIC

P08651

MPND

Q8N594

FUNCTION: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.FUNCTION: Probable protease (By similarity). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its degradation (PubMed:30982744). {ECO:0000250|UniProtKB:Q5VVJ2, ECO:0000269|PubMed:30982744}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMPNDchr19:3366664chr19:4357250ENST00000262966712349_362332472.0MotifJAMM motif
TgeneMPNDchr19:3366664chr19:4357250ENST00000359935511349_362282452.0MotifJAMM motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFICchr19:3366664chr19:4357250ENST00000341919+191_19510429.0DNA bindingCTF/NF-I
HgeneNFICchr19:3366664chr19:4357250ENST00000346156+191_1950669.0DNA bindingCTF/NF-I
HgeneNFICchr19:3366664chr19:4357250ENST00000395111+1101_1950548.3333333333334DNA bindingCTF/NF-I
HgeneNFICchr19:3366664chr19:4357250ENST00000443272+1111_19510509.0DNA bindingCTF/NF-I
HgeneNFICchr19:3366664chr19:4357250ENST00000586919+181_1950407.0DNA bindingCTF/NF-I
HgeneNFICchr19:3366664chr19:4357250ENST00000589123+1111_1950500.0DNA bindingCTF/NF-I
HgeneNFICchr19:3366664chr19:4357250ENST00000590282+1101_19510461.6666666666667DNA bindingCTF/NF-I
HgeneNFICchr19:3366664chr19:4357250ENST00000341919+19404_41210429.0Motif9aaTAD
HgeneNFICchr19:3366664chr19:4357250ENST00000346156+19404_4120669.0Motif9aaTAD
HgeneNFICchr19:3366664chr19:4357250ENST00000395111+110404_4120548.3333333333334Motif9aaTAD
HgeneNFICchr19:3366664chr19:4357250ENST00000443272+111404_41210509.0Motif9aaTAD
HgeneNFICchr19:3366664chr19:4357250ENST00000586919+18404_4120407.0Motif9aaTAD
HgeneNFICchr19:3366664chr19:4357250ENST00000589123+111404_4120500.0Motif9aaTAD
HgeneNFICchr19:3366664chr19:4357250ENST00000590282+110404_41210461.6666666666667Motif9aaTAD
TgeneMPNDchr19:3366664chr19:4357250ENST00000262966712182_187332472.0Compositional biasNote=Poly-Glu
TgeneMPNDchr19:3366664chr19:4357250ENST00000262966712191_195332472.0Compositional biasNote=Poly-Glu
TgeneMPNDchr19:3366664chr19:4357250ENST0000026296671236_68332472.0Compositional biasNote=Gly-rich
TgeneMPNDchr19:3366664chr19:4357250ENST00000359935511182_187282452.0Compositional biasNote=Poly-Glu
TgeneMPNDchr19:3366664chr19:4357250ENST00000359935511191_195282452.0Compositional biasNote=Poly-Glu
TgeneMPNDchr19:3366664chr19:4357250ENST0000035993551136_68282452.0Compositional biasNote=Gly-rich
TgeneMPNDchr19:3366664chr19:4357250ENST00000262966712272_407332472.0DomainMPN
TgeneMPNDchr19:3366664chr19:4357250ENST0000026296671271_166332472.0DomainRAMA
TgeneMPNDchr19:3366664chr19:4357250ENST00000359935511272_407282452.0DomainMPN
TgeneMPNDchr19:3366664chr19:4357250ENST0000035993551171_166282452.0DomainRAMA


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Fusion Gene Sequence for NFIC-MPND


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>58915_58915_1_NFIC-MPND_NFIC_chr19_3366664_ENST00000341919_MPND_chr19_4357250_ENST00000262966_length(transcript)=622nt_BP=118nt
GGGGGGGCGGGGGGGTGGTTTGGAAAAATGACTCAGTAAGTTCAGCGCGCCCGCTCCGGCCGGCCCTGCGCCTCCCGCCGCGCCCGGGAT
GTATTCGTCCCCGCTCTGCCTCACCCAGATCTACCAGAGCCTGTTCCTGCGGGGCCTGTCCCTGGTGGGCTGGTACCACAGCCACCCACA
CAGCCCGGCGCTGCCATCTCTGCAGGACATCGACGCACAGATGGACTACCAGCTGCGGCTGCAGGGCTCCAGCAATGGCTTCCAGCCCTG
CCTCGCCCTGCTCTGCTCCCCTTACTATTCTGGCAACCCAGGCCCCGAGTCCAAGATCTCACCTTTCTGGGTGATGCCTCCTCCCGAGAT
GCTGCTGGTGGAGTTCTACAAGGGTTCCCCTGACCTCGTGAGGCTCCAGGAACCCTGGAGCCAGGAGCACACCTACCTCGACAAGCTTAA
GATCTCCTTGGCCAGCAGGACGCCCAAGGACCAGAGCCTGTGTCACGTCCTGGAACAGGTGTGCGGCGTCCTCAAGCAGGGGAGCTGAGC

>58915_58915_1_NFIC-MPND_NFIC_chr19_3366664_ENST00000341919_MPND_chr19_4357250_ENST00000262966_length(amino acids)=149AA_BP=9
MYSSPLCLTQIYQSLFLRGLSLVGWYHSHPHSPALPSLQDIDAQMDYQLRLQGSSNGFQPCLALLCSPYYSGNPGPESKISPFWVMPPPE

--------------------------------------------------------------
>58915_58915_2_NFIC-MPND_NFIC_chr19_3366664_ENST00000341919_MPND_chr19_4357250_ENST00000359935_length(transcript)=707nt_BP=118nt
GGGGGGGCGGGGGGGTGGTTTGGAAAAATGACTCAGTAAGTTCAGCGCGCCCGCTCCGGCCGGCCCTGCGCCTCCCGCCGCGCCCGGGAT
GTATTCGTCCCCGCTCTGCCTCACCCAGATCTACCAGAGCCTGTTCCTGCGGGGCCTGTCCCTGGTGGGCTGGTACCACAGCCACCCACA
CAGCCCGGCGCTGCCATCTCTGCAGGACATCGACGCACAGATGGACTACCAGCTGCGGCTGCAGGGCTCCAGCAATGGCTTCCAGCCCTG
CCTCGCCCTGCTCTGCTCCCCTTACTATTCTGGCAACCCAGGCCCCGAGTCCAAGATCTCACCTTTCTGGGTGATGCCTCCTCCCGAGCA
AAGGCCCAGTGACTATGGCATCCCCATGGATGTGGAGATGGCCTACGTCCAGGACAGCTTCCTGACCAATGACATCCTTCACGAGATGAT
GCTGCTGGTGGAGTTCTACAAGGGTTCCCCTGACCTCGTGAGGCTCCAGGAACCCTGGAGCCAGGAGCACACCTACCTCGACAAGCTTAA
GATCTCCTTGGCCAGCAGGACGCCCAAGGACCAGAGCCTGTGTCACGTCCTGGAACAGGTGTGCGGCGTCCTCAAGCAGGGGAGCTGAGC

>58915_58915_2_NFIC-MPND_NFIC_chr19_3366664_ENST00000341919_MPND_chr19_4357250_ENST00000359935_length(amino acids)=179AA_BP=9
MYSSPLCLTQIYQSLFLRGLSLVGWYHSHPHSPALPSLQDIDAQMDYQLRLQGSSNGFQPCLALLCSPYYSGNPGPESKISPFWVMPPPE

--------------------------------------------------------------
>58915_58915_3_NFIC-MPND_NFIC_chr19_3366664_ENST00000341919_MPND_chr19_4357250_ENST00000599840_length(transcript)=698nt_BP=118nt
GGGGGGGCGGGGGGGTGGTTTGGAAAAATGACTCAGTAAGTTCAGCGCGCCCGCTCCGGCCGGCCCTGCGCCTCCCGCCGCGCCCGGGAT
GTATTCGTCCCCGCTCTGCCTCACCCAGATCTACCAGAGCCTGTTCCTGCGGGGCCTGTCCCTGGTGGGCTGGTACCACAGCCACCCACA
CAGCCCGGCGCTGCCATCTCTGCAGGACATCGACGCACAGATGGACTACCAGCTGCGGCTGCAGGGCTCCAGCAATGGCTTCCAGCCCTG
CCTCGCCCTGCTCTGCTCCCCTTACTATTCTGGCAACCCAGGCCCCGAGTCCAAGATCTCACCTTTCTGGGTGATGCCTCCTCCCGAGCA
AAGGCCCAGTGACTATGGCATCCCCATGGATGTGGAGATGGCCTACGTCCAGGACAGCTTCCTGACCAATGACATCCTTCACGAGATGAT
GCTGCTGGTGGAGTTCTACAAGGGTTCCCCTGACCTCGTGAGGCTCCAGGAACCCTGGAGCCAGGAGCACACCTACCTCGACAAGCTTAA
GATCTCCTTGGCCAGCAGGACGCCCAAGGACCAGAGCCTGTGTCACGTCCTGGAACAGGTGTGCGGCGTCCTCAAGCAGGGGAGCTGAGC

>58915_58915_3_NFIC-MPND_NFIC_chr19_3366664_ENST00000341919_MPND_chr19_4357250_ENST00000599840_length(amino acids)=179AA_BP=9
MYSSPLCLTQIYQSLFLRGLSLVGWYHSHPHSPALPSLQDIDAQMDYQLRLQGSSNGFQPCLALLCSPYYSGNPGPESKISPFWVMPPPE

--------------------------------------------------------------
>58915_58915_4_NFIC-MPND_NFIC_chr19_3366664_ENST00000443272_MPND_chr19_4357250_ENST00000262966_length(transcript)=585nt_BP=81nt
AAGTTCAGCGCGCCCGCTCCGGCCGGCCCTGCGCCTCCCGCCGCGCCCGGGATGTATTCGTCCCCGCTCTGCCTCACCCAGATCTACCAG
AGCCTGTTCCTGCGGGGCCTGTCCCTGGTGGGCTGGTACCACAGCCACCCACACAGCCCGGCGCTGCCATCTCTGCAGGACATCGACGCA
CAGATGGACTACCAGCTGCGGCTGCAGGGCTCCAGCAATGGCTTCCAGCCCTGCCTCGCCCTGCTCTGCTCCCCTTACTATTCTGGCAAC
CCAGGCCCCGAGTCCAAGATCTCACCTTTCTGGGTGATGCCTCCTCCCGAGATGCTGCTGGTGGAGTTCTACAAGGGTTCCCCTGACCTC
GTGAGGCTCCAGGAACCCTGGAGCCAGGAGCACACCTACCTCGACAAGCTTAAGATCTCCTTGGCCAGCAGGACGCCCAAGGACCAGAGC
CTGTGTCACGTCCTGGAACAGGTGTGCGGCGTCCTCAAGCAGGGGAGCTGAGCCTTCCAGGGCAGGGTGGGCTCCAGTTGTCTTGAGGGT

>58915_58915_4_NFIC-MPND_NFIC_chr19_3366664_ENST00000443272_MPND_chr19_4357250_ENST00000262966_length(amino acids)=149AA_BP=9
MYSSPLCLTQIYQSLFLRGLSLVGWYHSHPHSPALPSLQDIDAQMDYQLRLQGSSNGFQPCLALLCSPYYSGNPGPESKISPFWVMPPPE

--------------------------------------------------------------
>58915_58915_5_NFIC-MPND_NFIC_chr19_3366664_ENST00000443272_MPND_chr19_4357250_ENST00000359935_length(transcript)=670nt_BP=81nt
AAGTTCAGCGCGCCCGCTCCGGCCGGCCCTGCGCCTCCCGCCGCGCCCGGGATGTATTCGTCCCCGCTCTGCCTCACCCAGATCTACCAG
AGCCTGTTCCTGCGGGGCCTGTCCCTGGTGGGCTGGTACCACAGCCACCCACACAGCCCGGCGCTGCCATCTCTGCAGGACATCGACGCA
CAGATGGACTACCAGCTGCGGCTGCAGGGCTCCAGCAATGGCTTCCAGCCCTGCCTCGCCCTGCTCTGCTCCCCTTACTATTCTGGCAAC
CCAGGCCCCGAGTCCAAGATCTCACCTTTCTGGGTGATGCCTCCTCCCGAGCAAAGGCCCAGTGACTATGGCATCCCCATGGATGTGGAG
ATGGCCTACGTCCAGGACAGCTTCCTGACCAATGACATCCTTCACGAGATGATGCTGCTGGTGGAGTTCTACAAGGGTTCCCCTGACCTC
GTGAGGCTCCAGGAACCCTGGAGCCAGGAGCACACCTACCTCGACAAGCTTAAGATCTCCTTGGCCAGCAGGACGCCCAAGGACCAGAGC
CTGTGTCACGTCCTGGAACAGGTGTGCGGCGTCCTCAAGCAGGGGAGCTGAGCCTTCCAGGGCAGGGTGGGCTCCAGTTGTCTTGAGGGT

>58915_58915_5_NFIC-MPND_NFIC_chr19_3366664_ENST00000443272_MPND_chr19_4357250_ENST00000359935_length(amino acids)=179AA_BP=9
MYSSPLCLTQIYQSLFLRGLSLVGWYHSHPHSPALPSLQDIDAQMDYQLRLQGSSNGFQPCLALLCSPYYSGNPGPESKISPFWVMPPPE

--------------------------------------------------------------
>58915_58915_6_NFIC-MPND_NFIC_chr19_3366664_ENST00000443272_MPND_chr19_4357250_ENST00000599840_length(transcript)=661nt_BP=81nt
AAGTTCAGCGCGCCCGCTCCGGCCGGCCCTGCGCCTCCCGCCGCGCCCGGGATGTATTCGTCCCCGCTCTGCCTCACCCAGATCTACCAG
AGCCTGTTCCTGCGGGGCCTGTCCCTGGTGGGCTGGTACCACAGCCACCCACACAGCCCGGCGCTGCCATCTCTGCAGGACATCGACGCA
CAGATGGACTACCAGCTGCGGCTGCAGGGCTCCAGCAATGGCTTCCAGCCCTGCCTCGCCCTGCTCTGCTCCCCTTACTATTCTGGCAAC
CCAGGCCCCGAGTCCAAGATCTCACCTTTCTGGGTGATGCCTCCTCCCGAGCAAAGGCCCAGTGACTATGGCATCCCCATGGATGTGGAG
ATGGCCTACGTCCAGGACAGCTTCCTGACCAATGACATCCTTCACGAGATGATGCTGCTGGTGGAGTTCTACAAGGGTTCCCCTGACCTC
GTGAGGCTCCAGGAACCCTGGAGCCAGGAGCACACCTACCTCGACAAGCTTAAGATCTCCTTGGCCAGCAGGACGCCCAAGGACCAGAGC
CTGTGTCACGTCCTGGAACAGGTGTGCGGCGTCCTCAAGCAGGGGAGCTGAGCCTTCCAGGGCAGGGTGGGCTCCAGTTGTCTTGAGGGT

>58915_58915_6_NFIC-MPND_NFIC_chr19_3366664_ENST00000443272_MPND_chr19_4357250_ENST00000599840_length(amino acids)=179AA_BP=9
MYSSPLCLTQIYQSLFLRGLSLVGWYHSHPHSPALPSLQDIDAQMDYQLRLQGSSNGFQPCLALLCSPYYSGNPGPESKISPFWVMPPPE

--------------------------------------------------------------
>58915_58915_7_NFIC-MPND_NFIC_chr19_3366664_ENST00000590282_MPND_chr19_4357250_ENST00000262966_length(transcript)=588nt_BP=84nt
AGTAAGTTCAGCGCGCCCGCTCCGGCCGGCCCTGCGCCTCCCGCCGCGCCCGGGATGTATTCGTCCCCGCTCTGCCTCACCCAGATCTAC
CAGAGCCTGTTCCTGCGGGGCCTGTCCCTGGTGGGCTGGTACCACAGCCACCCACACAGCCCGGCGCTGCCATCTCTGCAGGACATCGAC
GCACAGATGGACTACCAGCTGCGGCTGCAGGGCTCCAGCAATGGCTTCCAGCCCTGCCTCGCCCTGCTCTGCTCCCCTTACTATTCTGGC
AACCCAGGCCCCGAGTCCAAGATCTCACCTTTCTGGGTGATGCCTCCTCCCGAGATGCTGCTGGTGGAGTTCTACAAGGGTTCCCCTGAC
CTCGTGAGGCTCCAGGAACCCTGGAGCCAGGAGCACACCTACCTCGACAAGCTTAAGATCTCCTTGGCCAGCAGGACGCCCAAGGACCAG
AGCCTGTGTCACGTCCTGGAACAGGTGTGCGGCGTCCTCAAGCAGGGGAGCTGAGCCTTCCAGGGCAGGGTGGGCTCCAGTTGTCTTGAG

>58915_58915_7_NFIC-MPND_NFIC_chr19_3366664_ENST00000590282_MPND_chr19_4357250_ENST00000262966_length(amino acids)=149AA_BP=9
MYSSPLCLTQIYQSLFLRGLSLVGWYHSHPHSPALPSLQDIDAQMDYQLRLQGSSNGFQPCLALLCSPYYSGNPGPESKISPFWVMPPPE

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>58915_58915_8_NFIC-MPND_NFIC_chr19_3366664_ENST00000590282_MPND_chr19_4357250_ENST00000359935_length(transcript)=673nt_BP=84nt
AGTAAGTTCAGCGCGCCCGCTCCGGCCGGCCCTGCGCCTCCCGCCGCGCCCGGGATGTATTCGTCCCCGCTCTGCCTCACCCAGATCTAC
CAGAGCCTGTTCCTGCGGGGCCTGTCCCTGGTGGGCTGGTACCACAGCCACCCACACAGCCCGGCGCTGCCATCTCTGCAGGACATCGAC
GCACAGATGGACTACCAGCTGCGGCTGCAGGGCTCCAGCAATGGCTTCCAGCCCTGCCTCGCCCTGCTCTGCTCCCCTTACTATTCTGGC
AACCCAGGCCCCGAGTCCAAGATCTCACCTTTCTGGGTGATGCCTCCTCCCGAGCAAAGGCCCAGTGACTATGGCATCCCCATGGATGTG
GAGATGGCCTACGTCCAGGACAGCTTCCTGACCAATGACATCCTTCACGAGATGATGCTGCTGGTGGAGTTCTACAAGGGTTCCCCTGAC
CTCGTGAGGCTCCAGGAACCCTGGAGCCAGGAGCACACCTACCTCGACAAGCTTAAGATCTCCTTGGCCAGCAGGACGCCCAAGGACCAG
AGCCTGTGTCACGTCCTGGAACAGGTGTGCGGCGTCCTCAAGCAGGGGAGCTGAGCCTTCCAGGGCAGGGTGGGCTCCAGTTGTCTTGAG

>58915_58915_8_NFIC-MPND_NFIC_chr19_3366664_ENST00000590282_MPND_chr19_4357250_ENST00000359935_length(amino acids)=179AA_BP=9
MYSSPLCLTQIYQSLFLRGLSLVGWYHSHPHSPALPSLQDIDAQMDYQLRLQGSSNGFQPCLALLCSPYYSGNPGPESKISPFWVMPPPE

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>58915_58915_9_NFIC-MPND_NFIC_chr19_3366664_ENST00000590282_MPND_chr19_4357250_ENST00000599840_length(transcript)=664nt_BP=84nt
AGTAAGTTCAGCGCGCCCGCTCCGGCCGGCCCTGCGCCTCCCGCCGCGCCCGGGATGTATTCGTCCCCGCTCTGCCTCACCCAGATCTAC
CAGAGCCTGTTCCTGCGGGGCCTGTCCCTGGTGGGCTGGTACCACAGCCACCCACACAGCCCGGCGCTGCCATCTCTGCAGGACATCGAC
GCACAGATGGACTACCAGCTGCGGCTGCAGGGCTCCAGCAATGGCTTCCAGCCCTGCCTCGCCCTGCTCTGCTCCCCTTACTATTCTGGC
AACCCAGGCCCCGAGTCCAAGATCTCACCTTTCTGGGTGATGCCTCCTCCCGAGCAAAGGCCCAGTGACTATGGCATCCCCATGGATGTG
GAGATGGCCTACGTCCAGGACAGCTTCCTGACCAATGACATCCTTCACGAGATGATGCTGCTGGTGGAGTTCTACAAGGGTTCCCCTGAC
CTCGTGAGGCTCCAGGAACCCTGGAGCCAGGAGCACACCTACCTCGACAAGCTTAAGATCTCCTTGGCCAGCAGGACGCCCAAGGACCAG
AGCCTGTGTCACGTCCTGGAACAGGTGTGCGGCGTCCTCAAGCAGGGGAGCTGAGCCTTCCAGGGCAGGGTGGGCTCCAGTTGTCTTGAG

>58915_58915_9_NFIC-MPND_NFIC_chr19_3366664_ENST00000590282_MPND_chr19_4357250_ENST00000599840_length(amino acids)=179AA_BP=9
MYSSPLCLTQIYQSLFLRGLSLVGWYHSHPHSPALPSLQDIDAQMDYQLRLQGSSNGFQPCLALLCSPYYSGNPGPESKISPFWVMPPPE

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Fusion Gene PPI Analysis for NFIC-MPND


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NFIC-MPND


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NFIC-MPND


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource