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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NFIC-SPATA33 (FusionGDB2 ID:58925)

Fusion Gene Summary for NFIC-SPATA33

check button Fusion gene summary
Fusion gene informationFusion gene name: NFIC-SPATA33
Fusion gene ID: 58925
HgeneTgene
Gene symbol

NFIC

SPATA33

Gene ID

4782

124045

Gene namenuclear factor I Cspermatogenesis associated 33
SynonymsCTF|CTF5|NF-I|NFIC16orf55
Cytomap

19p13.3

16q24.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear factor 1 C-typeCCAAT-box-binding transcription factorNF-I/CNF1-CTGGCA-binding proteinnuclear factor I/C (CCAAT-binding transcription factor)spermatogenesis-associated protein 33
Modification date2020031320200313
UniProtAcc

P08651

Q96N06

Ensembl transtripts involved in fusion geneENST00000346156, ENST00000395111, 
ENST00000586919, ENST00000589123, 
ENST00000341919, ENST00000443272, 
ENST00000588839, ENST00000590282, 
ENST00000566857, ENST00000568929, 
ENST00000579310, ENST00000301031, 
Fusion gene scores* DoF score30 X 20 X 13=78003 X 1 X 3=9
# samples 363
** MAII scorelog2(36/7800*10)=-4.4374053123073
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NFIC [Title/Abstract] AND SPATA33 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNFIC(3359683)-SPATA33(89735694), # samples:1
Anticipated loss of major functional domain due to fusion event.NFIC-SPATA33 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFIC

GO:0000122

negative regulation of transcription by RNA polymerase II

19706729

HgeneNFIC

GO:0045944

positive regulation of transcription by RNA polymerase II

1524678|19706729


check buttonFusion gene breakpoints across NFIC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SPATA33 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5K2-01ANFICchr19

3359683

+SPATA33chr16

89735694

+


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Fusion Gene ORF analysis for NFIC-SPATA33

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000346156ENST00000566857NFICchr19

3359683

+SPATA33chr16

89735694

+
5CDS-intronENST00000346156ENST00000568929NFICchr19

3359683

+SPATA33chr16

89735694

+
5CDS-intronENST00000395111ENST00000566857NFICchr19

3359683

+SPATA33chr16

89735694

+
5CDS-intronENST00000395111ENST00000568929NFICchr19

3359683

+SPATA33chr16

89735694

+
5CDS-intronENST00000586919ENST00000566857NFICchr19

3359683

+SPATA33chr16

89735694

+
5CDS-intronENST00000586919ENST00000568929NFICchr19

3359683

+SPATA33chr16

89735694

+
5CDS-intronENST00000589123ENST00000566857NFICchr19

3359683

+SPATA33chr16

89735694

+
5CDS-intronENST00000589123ENST00000568929NFICchr19

3359683

+SPATA33chr16

89735694

+
Frame-shiftENST00000346156ENST00000579310NFICchr19

3359683

+SPATA33chr16

89735694

+
Frame-shiftENST00000395111ENST00000579310NFICchr19

3359683

+SPATA33chr16

89735694

+
Frame-shiftENST00000586919ENST00000579310NFICchr19

3359683

+SPATA33chr16

89735694

+
Frame-shiftENST00000589123ENST00000579310NFICchr19

3359683

+SPATA33chr16

89735694

+
In-frameENST00000346156ENST00000301031NFICchr19

3359683

+SPATA33chr16

89735694

+
In-frameENST00000395111ENST00000301031NFICchr19

3359683

+SPATA33chr16

89735694

+
In-frameENST00000586919ENST00000301031NFICchr19

3359683

+SPATA33chr16

89735694

+
In-frameENST00000589123ENST00000301031NFICchr19

3359683

+SPATA33chr16

89735694

+
intron-3CDSENST00000341919ENST00000301031NFICchr19

3359683

+SPATA33chr16

89735694

+
intron-3CDSENST00000341919ENST00000579310NFICchr19

3359683

+SPATA33chr16

89735694

+
intron-3CDSENST00000443272ENST00000301031NFICchr19

3359683

+SPATA33chr16

89735694

+
intron-3CDSENST00000443272ENST00000579310NFICchr19

3359683

+SPATA33chr16

89735694

+
intron-3CDSENST00000588839ENST00000301031NFICchr19

3359683

+SPATA33chr16

89735694

+
intron-3CDSENST00000588839ENST00000579310NFICchr19

3359683

+SPATA33chr16

89735694

+
intron-3CDSENST00000590282ENST00000301031NFICchr19

3359683

+SPATA33chr16

89735694

+
intron-3CDSENST00000590282ENST00000579310NFICchr19

3359683

+SPATA33chr16

89735694

+
intron-intronENST00000341919ENST00000566857NFICchr19

3359683

+SPATA33chr16

89735694

+
intron-intronENST00000341919ENST00000568929NFICchr19

3359683

+SPATA33chr16

89735694

+
intron-intronENST00000443272ENST00000566857NFICchr19

3359683

+SPATA33chr16

89735694

+
intron-intronENST00000443272ENST00000568929NFICchr19

3359683

+SPATA33chr16

89735694

+
intron-intronENST00000588839ENST00000566857NFICchr19

3359683

+SPATA33chr16

89735694

+
intron-intronENST00000588839ENST00000568929NFICchr19

3359683

+SPATA33chr16

89735694

+
intron-intronENST00000590282ENST00000566857NFICchr19

3359683

+SPATA33chr16

89735694

+
intron-intronENST00000590282ENST00000568929NFICchr19

3359683

+SPATA33chr16

89735694

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000589123NFICchr193359683+ENST00000301031SPATA33chr1689735694+21051231212310300
ENST00000346156NFICchr193359683+ENST00000301031SPATA33chr1689735694+2050681157255300
ENST00000395111NFICchr193359683+ENST00000301031SPATA33chr1689735694+2021391128226300
ENST00000586919NFICchr193359683+ENST00000301031SPATA33chr1689735694+198531092190300

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000589123ENST00000301031NFICchr193359683+SPATA33chr1689735694+0.84378520.1562148
ENST00000346156ENST00000301031NFICchr193359683+SPATA33chr1689735694+0.933500470.066499546
ENST00000395111ENST00000301031NFICchr193359683+SPATA33chr1689735694+0.97680880.023191275
ENST00000586919ENST00000301031NFICchr193359683+SPATA33chr1689735694+0.98089210.019107908

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Fusion Genomic Features for NFIC-SPATA33


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NFICchr193359683+SPATA33chr1689735693+0.0003948730.9996051
NFICchr193359683+SPATA33chr1689735693+0.0003948730.9996051

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NFIC-SPATA33


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:3359683/chr16:89735694)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFIC

P08651

SPATA33

Q96N06

FUNCTION: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFICchr19:3359683chr16:89735694ENST00000341919+191_1950429.0DNA bindingCTF/NF-I
HgeneNFICchr19:3359683chr16:89735694ENST00000346156+191_1951669.0DNA bindingCTF/NF-I
HgeneNFICchr19:3359683chr16:89735694ENST00000395111+1101_1951548.3333333333334DNA bindingCTF/NF-I
HgeneNFICchr19:3359683chr16:89735694ENST00000443272+1111_1950509.0DNA bindingCTF/NF-I
HgeneNFICchr19:3359683chr16:89735694ENST00000586919+181_1951407.0DNA bindingCTF/NF-I
HgeneNFICchr19:3359683chr16:89735694ENST00000589123+1111_1951500.0DNA bindingCTF/NF-I
HgeneNFICchr19:3359683chr16:89735694ENST00000590282+1101_1950461.6666666666667DNA bindingCTF/NF-I
HgeneNFICchr19:3359683chr16:89735694ENST00000341919+19404_4120429.0Motif9aaTAD
HgeneNFICchr19:3359683chr16:89735694ENST00000346156+19404_4121669.0Motif9aaTAD
HgeneNFICchr19:3359683chr16:89735694ENST00000395111+110404_4121548.3333333333334Motif9aaTAD
HgeneNFICchr19:3359683chr16:89735694ENST00000443272+111404_4120509.0Motif9aaTAD
HgeneNFICchr19:3359683chr16:89735694ENST00000586919+18404_4121407.0Motif9aaTAD
HgeneNFICchr19:3359683chr16:89735694ENST00000589123+111404_4121500.0Motif9aaTAD
HgeneNFICchr19:3359683chr16:89735694ENST00000590282+110404_4120461.6666666666667Motif9aaTAD


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Fusion Gene Sequence for NFIC-SPATA33


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>58925_58925_1_NFIC-SPATA33_NFIC_chr19_3359683_ENST00000346156_SPATA33_chr16_89735694_ENST00000301031_length(transcript)=2050nt_BP=68nt
CCCCCCCTCGCCGGGGACCGAGCGCGCTCGCTCCGGCGCCGGCCTCGCCTCCTCGCAGCAGCGCCATGAGAAACCTGATGTAAAGCAAAA
GTCCAGCAGGAAGAAAGTGGTCGTTCCACAGATCATCATCACGCGAGCGTCGAATGAGACGCTAGTCAGTTGCAGTTCCAGCGGGAGTGA
CCAGCAGAGAACCATTCGGGAGCCGGAGGACTGGGGCCCCTACCGGCGGCACAGGAACCCCAGTACAGCAGACGCCTATAATTCACATCT
CAAAGAATAAACAAGCACCTTTGCATGGCACTCGCTACTCCCTGCGATAGGCGTCTCGGGAACAGCCGCCTCACCCTGTGAGAAGCCGAG
GCCCCTTCTCCAGTGCTCTCGGGGAGGTTGCACCAGGCCCACCCCACCCTGTGAGAAACTGCAGCCCCCTTCTCCAGTGCTTTCGGGGAG
GGTGCACCAGGCCCGCCCCACCTTGTGAGAAGCCGTGGCCCCCTTCTCCAGTGCTCTCAGGGAGGGTGCACCAGGCCTGCCCCCGCCGTG
AGAAACTGCAGTCCCCTTCTCCAGTGCTCTCGGGGAGGGTGCACCAGGCCCACCCCACCCTGTGAGAACCTGCAGCCCCCTTCTCCAATG
CTCTCGGGGAGGGTACACCAGGGTTGCCCCACCCTGTGAGAAGCCACCGCCCCCTTCTCCAGTGCTCTCGGGGAGGGTGCACCAGGGCTG
CCCCACGCTGTAAGAAGCCGCCGCCCCCTTCTCCAGTGCTCTCCAGCCCGCCCCACCCTGTGAGAAGCCATGGCCCCTTCTCCAGTGCTT
TTGGGGAGGGTGCACCAGGGCCACCCCACCCTGTGAGAAGCCGTGGCCCCCTTCTCCAGTGCTTTCGGGGAGGGTACACCAGGCCCGCCC
CACCCTGTGAGAAGCCGTGGCCCCCTTCTCCCGTGCTCTCAGGGAGGGTGCACCAGGCCTGCCCCCGCCTTGAGAAACTGCAGCCCCCTT
CTCCAGTGCTCTGGGGGAGGGTGCACCAGGCCTGCCCACCCTGTGAGAAACTGCACCCCCTTCTCCAGTGCTCTCGGGGAGGGTGCACCA
GGCCCGCCCCACCCTGTGAGAAGCCGCAGCCCGTTCTCCATTGCCATTTGGTCCTGCCTTCCCCAGAGCTGCTAGCAGCTCGGTCGAGGC
AAGAGTGACTGGCTCAGAGAGCGAGCTTTGTGGTATTGATAAATGAATAAATTAGTATGTTCATGTTGGAAGTGGCTGGCTCTGCAGAGT
GATGGACAGCAGGTGGCATCTTACATTGTGATTTGTGGTGCACAGTTAAAACACTTCCCTTCGTTTCAGAAGGAGACAATGTGAATACTT
GGAAATTATAGTGAATAAGATGCCTCCCAAACTTGAGGAAAAGGTCAGATTCTAAGAGCTAAACGTTAAGATGTAATGTTCCAGAACAAA
GAGGCCCAGAGTCACTGAACGGGGCCCCAGGGCTCCTAGCTTGAGTGTAATCTGAGTCAGCTTATGAAAAGGCCCCAAAGAAGAAAGTGG
AATGTGTGCTGGGCACATGGGACAGCCATGGCACTGAGACTTTGGAAGTGGCCTTGCCAGCGCTGTCCTGTCTTTCTGGCCCACAGATGA
GGGCTCCTGATTGTGGAAGGCCACGGAAGGGACCTGAACACGATGGCACGAGACAAGTTATCTCCTGTGACTGCTCCTCTCCAGCAACCC
TCAGCTCAGGCTAGACTTTCCCCCTGTGTTGAGAATGCCCTGCCCTGTGTGGAAGCCTGATGCATTTAGTGACAGTGTGTTAGCTTTGTT
AGTTTCTAGTCTGGCCAGCAGGCTTTCCATGTGATCTGCCATTGGCTTGCTTCAGTGGCCAGTGGAGCCAGGGGTGTCCACCAGAGTCTT
GGACACAGACTTCTGAGGTGGCAGCGGGAGGGAGCCTGCTCCCTGCCACACACGTACAATTTCTAATCCATACAGGCCTATGTAGTATAT

>58925_58925_1_NFIC-SPATA33_NFIC_chr19_3359683_ENST00000346156_SPATA33_chr16_89735694_ENST00000301031_length(amino acids)=300AA_BP=16
MLAALGKAGPNGNGERAAASHRVGRAWCTLPESTGEGGAVSHRVGRPGAPSPRALEKGAAVSQGGGRPGAPSLRAREKGATASHRVGRAW
CTLPESTGEGGHGFSQGGVALVHPPQKHWRRGHGFSQGGAGWRALEKGAAASYSVGQPWCTLPESTGEGGGGFSQGGATLVYPPREHWRR
GLQVLTGWGGPGAPSPRALEKGTAVSHGGGRPGAPSLRALEKGATASHKVGRAWCTLPESTGEGGCSFSQGGVGLVQPPREHWRRGLGFS

--------------------------------------------------------------
>58925_58925_2_NFIC-SPATA33_NFIC_chr19_3359683_ENST00000395111_SPATA33_chr16_89735694_ENST00000301031_length(transcript)=2021nt_BP=39nt
GCTCCGGCGCCGGCCTCGCCTCCTCGCAGCAGCGCCATGAGAAACCTGATGTAAAGCAAAAGTCCAGCAGGAAGAAAGTGGTCGTTCCAC
AGATCATCATCACGCGAGCGTCGAATGAGACGCTAGTCAGTTGCAGTTCCAGCGGGAGTGACCAGCAGAGAACCATTCGGGAGCCGGAGG
ACTGGGGCCCCTACCGGCGGCACAGGAACCCCAGTACAGCAGACGCCTATAATTCACATCTCAAAGAATAAACAAGCACCTTTGCATGGC
ACTCGCTACTCCCTGCGATAGGCGTCTCGGGAACAGCCGCCTCACCCTGTGAGAAGCCGAGGCCCCTTCTCCAGTGCTCTCGGGGAGGTT
GCACCAGGCCCACCCCACCCTGTGAGAAACTGCAGCCCCCTTCTCCAGTGCTTTCGGGGAGGGTGCACCAGGCCCGCCCCACCTTGTGAG
AAGCCGTGGCCCCCTTCTCCAGTGCTCTCAGGGAGGGTGCACCAGGCCTGCCCCCGCCGTGAGAAACTGCAGTCCCCTTCTCCAGTGCTC
TCGGGGAGGGTGCACCAGGCCCACCCCACCCTGTGAGAACCTGCAGCCCCCTTCTCCAATGCTCTCGGGGAGGGTACACCAGGGTTGCCC
CACCCTGTGAGAAGCCACCGCCCCCTTCTCCAGTGCTCTCGGGGAGGGTGCACCAGGGCTGCCCCACGCTGTAAGAAGCCGCCGCCCCCT
TCTCCAGTGCTCTCCAGCCCGCCCCACCCTGTGAGAAGCCATGGCCCCTTCTCCAGTGCTTTTGGGGAGGGTGCACCAGGGCCACCCCAC
CCTGTGAGAAGCCGTGGCCCCCTTCTCCAGTGCTTTCGGGGAGGGTACACCAGGCCCGCCCCACCCTGTGAGAAGCCGTGGCCCCCTTCT
CCCGTGCTCTCAGGGAGGGTGCACCAGGCCTGCCCCCGCCTTGAGAAACTGCAGCCCCCTTCTCCAGTGCTCTGGGGGAGGGTGCACCAG
GCCTGCCCACCCTGTGAGAAACTGCACCCCCTTCTCCAGTGCTCTCGGGGAGGGTGCACCAGGCCCGCCCCACCCTGTGAGAAGCCGCAG
CCCGTTCTCCATTGCCATTTGGTCCTGCCTTCCCCAGAGCTGCTAGCAGCTCGGTCGAGGCAAGAGTGACTGGCTCAGAGAGCGAGCTTT
GTGGTATTGATAAATGAATAAATTAGTATGTTCATGTTGGAAGTGGCTGGCTCTGCAGAGTGATGGACAGCAGGTGGCATCTTACATTGT
GATTTGTGGTGCACAGTTAAAACACTTCCCTTCGTTTCAGAAGGAGACAATGTGAATACTTGGAAATTATAGTGAATAAGATGCCTCCCA
AACTTGAGGAAAAGGTCAGATTCTAAGAGCTAAACGTTAAGATGTAATGTTCCAGAACAAAGAGGCCCAGAGTCACTGAACGGGGCCCCA
GGGCTCCTAGCTTGAGTGTAATCTGAGTCAGCTTATGAAAAGGCCCCAAAGAAGAAAGTGGAATGTGTGCTGGGCACATGGGACAGCCAT
GGCACTGAGACTTTGGAAGTGGCCTTGCCAGCGCTGTCCTGTCTTTCTGGCCCACAGATGAGGGCTCCTGATTGTGGAAGGCCACGGAAG
GGACCTGAACACGATGGCACGAGACAAGTTATCTCCTGTGACTGCTCCTCTCCAGCAACCCTCAGCTCAGGCTAGACTTTCCCCCTGTGT
TGAGAATGCCCTGCCCTGTGTGGAAGCCTGATGCATTTAGTGACAGTGTGTTAGCTTTGTTAGTTTCTAGTCTGGCCAGCAGGCTTTCCA
TGTGATCTGCCATTGGCTTGCTTCAGTGGCCAGTGGAGCCAGGGGTGTCCACCAGAGTCTTGGACACAGACTTCTGAGGTGGCAGCGGGA
GGGAGCCTGCTCCCTGCCACACACGTACAATTTCTAATCCATACAGGCCTATGTAGTATATACACACATACGCAGAGCCTTAGGAATTGT

>58925_58925_2_NFIC-SPATA33_NFIC_chr19_3359683_ENST00000395111_SPATA33_chr16_89735694_ENST00000301031_length(amino acids)=300AA_BP=16
MLAALGKAGPNGNGERAAASHRVGRAWCTLPESTGEGGAVSHRVGRPGAPSPRALEKGAAVSQGGGRPGAPSLRAREKGATASHRVGRAW
CTLPESTGEGGHGFSQGGVALVHPPQKHWRRGHGFSQGGAGWRALEKGAAASYSVGQPWCTLPESTGEGGGGFSQGGATLVYPPREHWRR
GLQVLTGWGGPGAPSPRALEKGTAVSHGGGRPGAPSLRALEKGATASHKVGRAWCTLPESTGEGGCSFSQGGVGLVQPPREHWRRGLGFS

--------------------------------------------------------------
>58925_58925_3_NFIC-SPATA33_NFIC_chr19_3359683_ENST00000586919_SPATA33_chr16_89735694_ENST00000301031_length(transcript)=1985nt_BP=3nt
ATGAGAAACCTGATGTAAAGCAAAAGTCCAGCAGGAAGAAAGTGGTCGTTCCACAGATCATCATCACGCGAGCGTCGAATGAGACGCTAG
TCAGTTGCAGTTCCAGCGGGAGTGACCAGCAGAGAACCATTCGGGAGCCGGAGGACTGGGGCCCCTACCGGCGGCACAGGAACCCCAGTA
CAGCAGACGCCTATAATTCACATCTCAAAGAATAAACAAGCACCTTTGCATGGCACTCGCTACTCCCTGCGATAGGCGTCTCGGGAACAG
CCGCCTCACCCTGTGAGAAGCCGAGGCCCCTTCTCCAGTGCTCTCGGGGAGGTTGCACCAGGCCCACCCCACCCTGTGAGAAACTGCAGC
CCCCTTCTCCAGTGCTTTCGGGGAGGGTGCACCAGGCCCGCCCCACCTTGTGAGAAGCCGTGGCCCCCTTCTCCAGTGCTCTCAGGGAGG
GTGCACCAGGCCTGCCCCCGCCGTGAGAAACTGCAGTCCCCTTCTCCAGTGCTCTCGGGGAGGGTGCACCAGGCCCACCCCACCCTGTGA
GAACCTGCAGCCCCCTTCTCCAATGCTCTCGGGGAGGGTACACCAGGGTTGCCCCACCCTGTGAGAAGCCACCGCCCCCTTCTCCAGTGC
TCTCGGGGAGGGTGCACCAGGGCTGCCCCACGCTGTAAGAAGCCGCCGCCCCCTTCTCCAGTGCTCTCCAGCCCGCCCCACCCTGTGAGA
AGCCATGGCCCCTTCTCCAGTGCTTTTGGGGAGGGTGCACCAGGGCCACCCCACCCTGTGAGAAGCCGTGGCCCCCTTCTCCAGTGCTTT
CGGGGAGGGTACACCAGGCCCGCCCCACCCTGTGAGAAGCCGTGGCCCCCTTCTCCCGTGCTCTCAGGGAGGGTGCACCAGGCCTGCCCC
CGCCTTGAGAAACTGCAGCCCCCTTCTCCAGTGCTCTGGGGGAGGGTGCACCAGGCCTGCCCACCCTGTGAGAAACTGCACCCCCTTCTC
CAGTGCTCTCGGGGAGGGTGCACCAGGCCCGCCCCACCCTGTGAGAAGCCGCAGCCCGTTCTCCATTGCCATTTGGTCCTGCCTTCCCCA
GAGCTGCTAGCAGCTCGGTCGAGGCAAGAGTGACTGGCTCAGAGAGCGAGCTTTGTGGTATTGATAAATGAATAAATTAGTATGTTCATG
TTGGAAGTGGCTGGCTCTGCAGAGTGATGGACAGCAGGTGGCATCTTACATTGTGATTTGTGGTGCACAGTTAAAACACTTCCCTTCGTT
TCAGAAGGAGACAATGTGAATACTTGGAAATTATAGTGAATAAGATGCCTCCCAAACTTGAGGAAAAGGTCAGATTCTAAGAGCTAAACG
TTAAGATGTAATGTTCCAGAACAAAGAGGCCCAGAGTCACTGAACGGGGCCCCAGGGCTCCTAGCTTGAGTGTAATCTGAGTCAGCTTAT
GAAAAGGCCCCAAAGAAGAAAGTGGAATGTGTGCTGGGCACATGGGACAGCCATGGCACTGAGACTTTGGAAGTGGCCTTGCCAGCGCTG
TCCTGTCTTTCTGGCCCACAGATGAGGGCTCCTGATTGTGGAAGGCCACGGAAGGGACCTGAACACGATGGCACGAGACAAGTTATCTCC
TGTGACTGCTCCTCTCCAGCAACCCTCAGCTCAGGCTAGACTTTCCCCCTGTGTTGAGAATGCCCTGCCCTGTGTGGAAGCCTGATGCAT
TTAGTGACAGTGTGTTAGCTTTGTTAGTTTCTAGTCTGGCCAGCAGGCTTTCCATGTGATCTGCCATTGGCTTGCTTCAGTGGCCAGTGG
AGCCAGGGGTGTCCACCAGAGTCTTGGACACAGACTTCTGAGGTGGCAGCGGGAGGGAGCCTGCTCCCTGCCACACACGTACAATTTCTA
ATCCATACAGGCCTATGTAGTATATACACACATACGCAGAGCCTTAGGAATTGTGAAAGGCCAATCAAAACTTGGGGCCCTAATTTCACT

>58925_58925_3_NFIC-SPATA33_NFIC_chr19_3359683_ENST00000586919_SPATA33_chr16_89735694_ENST00000301031_length(amino acids)=300AA_BP=16
MLAALGKAGPNGNGERAAASHRVGRAWCTLPESTGEGGAVSHRVGRPGAPSPRALEKGAAVSQGGGRPGAPSLRAREKGATASHRVGRAW
CTLPESTGEGGHGFSQGGVALVHPPQKHWRRGHGFSQGGAGWRALEKGAAASYSVGQPWCTLPESTGEGGGGFSQGGATLVYPPREHWRR
GLQVLTGWGGPGAPSPRALEKGTAVSHGGGRPGAPSLRALEKGATASHKVGRAWCTLPESTGEGGCSFSQGGVGLVQPPREHWRRGLGFS

--------------------------------------------------------------
>58925_58925_4_NFIC-SPATA33_NFIC_chr19_3359683_ENST00000589123_SPATA33_chr16_89735694_ENST00000301031_length(transcript)=2105nt_BP=123nt
GCTCGCTCCCTCCCCCGCGCGCCCTCCCTCGCCGCCTCCTCCCGCCGCCTGCGGCCCCCCCCTCGCCGGGGACCGAGCGCGCTCGCTCCG
GCGCCGGCCTCGCCTCCTCGCAGCAGCGCCATGAGAAACCTGATGTAAAGCAAAAGTCCAGCAGGAAGAAAGTGGTCGTTCCACAGATCA
TCATCACGCGAGCGTCGAATGAGACGCTAGTCAGTTGCAGTTCCAGCGGGAGTGACCAGCAGAGAACCATTCGGGAGCCGGAGGACTGGG
GCCCCTACCGGCGGCACAGGAACCCCAGTACAGCAGACGCCTATAATTCACATCTCAAAGAATAAACAAGCACCTTTGCATGGCACTCGC
TACTCCCTGCGATAGGCGTCTCGGGAACAGCCGCCTCACCCTGTGAGAAGCCGAGGCCCCTTCTCCAGTGCTCTCGGGGAGGTTGCACCA
GGCCCACCCCACCCTGTGAGAAACTGCAGCCCCCTTCTCCAGTGCTTTCGGGGAGGGTGCACCAGGCCCGCCCCACCTTGTGAGAAGCCG
TGGCCCCCTTCTCCAGTGCTCTCAGGGAGGGTGCACCAGGCCTGCCCCCGCCGTGAGAAACTGCAGTCCCCTTCTCCAGTGCTCTCGGGG
AGGGTGCACCAGGCCCACCCCACCCTGTGAGAACCTGCAGCCCCCTTCTCCAATGCTCTCGGGGAGGGTACACCAGGGTTGCCCCACCCT
GTGAGAAGCCACCGCCCCCTTCTCCAGTGCTCTCGGGGAGGGTGCACCAGGGCTGCCCCACGCTGTAAGAAGCCGCCGCCCCCTTCTCCA
GTGCTCTCCAGCCCGCCCCACCCTGTGAGAAGCCATGGCCCCTTCTCCAGTGCTTTTGGGGAGGGTGCACCAGGGCCACCCCACCCTGTG
AGAAGCCGTGGCCCCCTTCTCCAGTGCTTTCGGGGAGGGTACACCAGGCCCGCCCCACCCTGTGAGAAGCCGTGGCCCCCTTCTCCCGTG
CTCTCAGGGAGGGTGCACCAGGCCTGCCCCCGCCTTGAGAAACTGCAGCCCCCTTCTCCAGTGCTCTGGGGGAGGGTGCACCAGGCCTGC
CCACCCTGTGAGAAACTGCACCCCCTTCTCCAGTGCTCTCGGGGAGGGTGCACCAGGCCCGCCCCACCCTGTGAGAAGCCGCAGCCCGTT
CTCCATTGCCATTTGGTCCTGCCTTCCCCAGAGCTGCTAGCAGCTCGGTCGAGGCAAGAGTGACTGGCTCAGAGAGCGAGCTTTGTGGTA
TTGATAAATGAATAAATTAGTATGTTCATGTTGGAAGTGGCTGGCTCTGCAGAGTGATGGACAGCAGGTGGCATCTTACATTGTGATTTG
TGGTGCACAGTTAAAACACTTCCCTTCGTTTCAGAAGGAGACAATGTGAATACTTGGAAATTATAGTGAATAAGATGCCTCCCAAACTTG
AGGAAAAGGTCAGATTCTAAGAGCTAAACGTTAAGATGTAATGTTCCAGAACAAAGAGGCCCAGAGTCACTGAACGGGGCCCCAGGGCTC
CTAGCTTGAGTGTAATCTGAGTCAGCTTATGAAAAGGCCCCAAAGAAGAAAGTGGAATGTGTGCTGGGCACATGGGACAGCCATGGCACT
GAGACTTTGGAAGTGGCCTTGCCAGCGCTGTCCTGTCTTTCTGGCCCACAGATGAGGGCTCCTGATTGTGGAAGGCCACGGAAGGGACCT
GAACACGATGGCACGAGACAAGTTATCTCCTGTGACTGCTCCTCTCCAGCAACCCTCAGCTCAGGCTAGACTTTCCCCCTGTGTTGAGAA
TGCCCTGCCCTGTGTGGAAGCCTGATGCATTTAGTGACAGTGTGTTAGCTTTGTTAGTTTCTAGTCTGGCCAGCAGGCTTTCCATGTGAT
CTGCCATTGGCTTGCTTCAGTGGCCAGTGGAGCCAGGGGTGTCCACCAGAGTCTTGGACACAGACTTCTGAGGTGGCAGCGGGAGGGAGC
CTGCTCCCTGCCACACACGTACAATTTCTAATCCATACAGGCCTATGTAGTATATACACACATACGCAGAGCCTTAGGAATTGTGAAAGG

>58925_58925_4_NFIC-SPATA33_NFIC_chr19_3359683_ENST00000589123_SPATA33_chr16_89735694_ENST00000301031_length(amino acids)=300AA_BP=16
MLAALGKAGPNGNGERAAASHRVGRAWCTLPESTGEGGAVSHRVGRPGAPSPRALEKGAAVSQGGGRPGAPSLRAREKGATASHRVGRAW
CTLPESTGEGGHGFSQGGVALVHPPQKHWRRGHGFSQGGAGWRALEKGAAASYSVGQPWCTLPESTGEGGGGFSQGGATLVYPPREHWRR
GLQVLTGWGGPGAPSPRALEKGTAVSHGGGRPGAPSLRALEKGATASHKVGRAWCTLPESTGEGGCSFSQGGVGLVQPPREHWRRGLGFS

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Fusion Gene PPI Analysis for NFIC-SPATA33


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NFIC-SPATA33


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NFIC-SPATA33


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource