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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NFIC-TLE6 (FusionGDB2 ID:58927)

Fusion Gene Summary for NFIC-TLE6

check button Fusion gene summary
Fusion gene informationFusion gene name: NFIC-TLE6
Fusion gene ID: 58927
HgeneTgene
Gene symbol

NFIC

TLE6

Gene ID

4782

79816

Gene namenuclear factor I CTLE family member 6, subcortical maternal complex member
SynonymsCTF|CTF5|NF-I|NFIGRG6|PREMBL
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear factor 1 C-typeCCAAT-box-binding transcription factorNF-I/CNF1-CTGGCA-binding proteinnuclear factor I/C (CCAAT-binding transcription factor)transducin-like enhancer protein 6transducin like enhancer of split 6transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)
Modification date2020031320200313
UniProtAcc

P08651

.
Ensembl transtripts involved in fusion geneENST00000341919, ENST00000346156, 
ENST00000395111, ENST00000443272, 
ENST00000586919, ENST00000589123, 
ENST00000590282, ENST00000588839, 
ENST00000452088, ENST00000478073, 
ENST00000246112, ENST00000482627, 
Fusion gene scores* DoF score30 X 20 X 13=78005 X 5 X 5=125
# samples 367
** MAII scorelog2(36/7800*10)=-4.4374053123073
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/125*10)=-0.836501267717121
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NFIC [Title/Abstract] AND TLE6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNFIC(3382241)-TLE6(2980098), # samples:2
Anticipated loss of major functional domain due to fusion event.NFIC-TLE6 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
NFIC-TLE6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFIC

GO:0000122

negative regulation of transcription by RNA polymerase II

19706729

HgeneNFIC

GO:0045944

positive regulation of transcription by RNA polymerase II

1524678|19706729


check buttonFusion gene breakpoints across NFIC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TLE6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-VS-A9V0-01ANFICchr19

3382241

-TLE6chr19

2980098

+
ChimerDB4CESCTCGA-VS-A9V0-01ANFICchr19

3382241

+TLE6chr19

2980098

+


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Fusion Gene ORF analysis for NFIC-TLE6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000341919ENST00000452088NFICchr19

3382241

+TLE6chr19

2980098

+
5CDS-5UTRENST00000346156ENST00000452088NFICchr19

3382241

+TLE6chr19

2980098

+
5CDS-5UTRENST00000395111ENST00000452088NFICchr19

3382241

+TLE6chr19

2980098

+
5CDS-5UTRENST00000443272ENST00000452088NFICchr19

3382241

+TLE6chr19

2980098

+
5CDS-5UTRENST00000586919ENST00000452088NFICchr19

3382241

+TLE6chr19

2980098

+
5CDS-5UTRENST00000589123ENST00000452088NFICchr19

3382241

+TLE6chr19

2980098

+
5CDS-5UTRENST00000590282ENST00000452088NFICchr19

3382241

+TLE6chr19

2980098

+
5CDS-intronENST00000341919ENST00000478073NFICchr19

3382241

+TLE6chr19

2980098

+
5CDS-intronENST00000346156ENST00000478073NFICchr19

3382241

+TLE6chr19

2980098

+
5CDS-intronENST00000395111ENST00000478073NFICchr19

3382241

+TLE6chr19

2980098

+
5CDS-intronENST00000443272ENST00000478073NFICchr19

3382241

+TLE6chr19

2980098

+
5CDS-intronENST00000586919ENST00000478073NFICchr19

3382241

+TLE6chr19

2980098

+
5CDS-intronENST00000589123ENST00000478073NFICchr19

3382241

+TLE6chr19

2980098

+
5CDS-intronENST00000590282ENST00000478073NFICchr19

3382241

+TLE6chr19

2980098

+
Frame-shiftENST00000341919ENST00000246112NFICchr19

3382241

+TLE6chr19

2980098

+
Frame-shiftENST00000346156ENST00000246112NFICchr19

3382241

+TLE6chr19

2980098

+
Frame-shiftENST00000395111ENST00000246112NFICchr19

3382241

+TLE6chr19

2980098

+
Frame-shiftENST00000443272ENST00000246112NFICchr19

3382241

+TLE6chr19

2980098

+
Frame-shiftENST00000586919ENST00000246112NFICchr19

3382241

+TLE6chr19

2980098

+
Frame-shiftENST00000589123ENST00000246112NFICchr19

3382241

+TLE6chr19

2980098

+
Frame-shiftENST00000590282ENST00000246112NFICchr19

3382241

+TLE6chr19

2980098

+
In-frameENST00000341919ENST00000482627NFICchr19

3382241

+TLE6chr19

2980098

+
In-frameENST00000346156ENST00000482627NFICchr19

3382241

+TLE6chr19

2980098

+
In-frameENST00000395111ENST00000482627NFICchr19

3382241

+TLE6chr19

2980098

+
In-frameENST00000443272ENST00000482627NFICchr19

3382241

+TLE6chr19

2980098

+
In-frameENST00000586919ENST00000482627NFICchr19

3382241

+TLE6chr19

2980098

+
In-frameENST00000589123ENST00000482627NFICchr19

3382241

+TLE6chr19

2980098

+
In-frameENST00000590282ENST00000482627NFICchr19

3382241

+TLE6chr19

2980098

+
intron-3CDSENST00000588839ENST00000246112NFICchr19

3382241

+TLE6chr19

2980098

+
intron-3CDSENST00000588839ENST00000482627NFICchr19

3382241

+TLE6chr19

2980098

+
intron-5UTRENST00000588839ENST00000452088NFICchr19

3382241

+TLE6chr19

2980098

+
intron-intronENST00000588839ENST00000478073NFICchr19

3382241

+TLE6chr19

2980098

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000589123NFICchr193382241+ENST00000482627TLE6chr192980098+96365548680210
ENST00000346156NFICchr193382241+ENST00000482627TLE6chr192980098+90860065625186
ENST00000395111NFICchr193382241+ENST00000482627TLE6chr192980098+87957136596186
ENST00000586919NFICchr193382241+ENST00000482627TLE6chr192980098+8435350560186
ENST00000341919NFICchr193382241+ENST00000482627TLE6chr192980098+95865088675195
ENST00000590282NFICchr193382241+ENST00000482627TLE6chr192980098+92461654641195
ENST00000443272NFICchr193382241+ENST00000482627TLE6chr192980098+92161351638195

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000589123ENST00000482627NFICchr193382241+TLE6chr192980098+0.0072149130.9927851
ENST00000346156ENST00000482627NFICchr193382241+TLE6chr192980098+0.0068100760.9931899
ENST00000395111ENST00000482627NFICchr193382241+TLE6chr192980098+0.0070239170.99297607
ENST00000586919ENST00000482627NFICchr193382241+TLE6chr192980098+0.0078076910.9921923
ENST00000341919ENST00000482627NFICchr193382241+TLE6chr192980098+0.0104143960.9895856
ENST00000590282ENST00000482627NFICchr193382241+TLE6chr192980098+0.0094274950.9905725
ENST00000443272ENST00000482627NFICchr193382241+TLE6chr192980098+0.0098265430.99017346

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Fusion Genomic Features for NFIC-TLE6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NFICchr193382241+TLE6chr192980097+8.70E-101
NFICchr193382241+TLE6chr192980097+8.70E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NFIC-TLE6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:3382241/chr19:2980098)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFIC

P08651

.
FUNCTION: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTLE6chr19:3382241chr19:2980098ENST00000246112117284_32217573.0RepeatNote=WD 1
TgeneTLE6chr19:3382241chr19:2980098ENST00000246112117332_37217573.0RepeatNote=WD 2
TgeneTLE6chr19:3382241chr19:2980098ENST00000246112117377_41617573.0RepeatNote=WD 3
TgeneTLE6chr19:3382241chr19:2980098ENST00000246112117419_45617573.0RepeatNote=WD 4
TgeneTLE6chr19:3382241chr19:2980098ENST00000246112117458_49717573.0RepeatNote=WD 5
TgeneTLE6chr19:3382241chr19:2980098ENST00000246112117499_53817573.0RepeatNote=WD 6
TgeneTLE6chr19:3382241chr19:2980098ENST00000246112117540_57117573.0RepeatNote=WD 7
TgeneTLE6chr19:3382241chr19:2980098ENST00000452088016284_3220450.0RepeatNote=WD 1
TgeneTLE6chr19:3382241chr19:2980098ENST00000452088016332_3720450.0RepeatNote=WD 2
TgeneTLE6chr19:3382241chr19:2980098ENST00000452088016377_4160450.0RepeatNote=WD 3
TgeneTLE6chr19:3382241chr19:2980098ENST00000452088016419_4560450.0RepeatNote=WD 4
TgeneTLE6chr19:3382241chr19:2980098ENST00000452088016458_4970450.0RepeatNote=WD 5
TgeneTLE6chr19:3382241chr19:2980098ENST00000452088016499_5380450.0RepeatNote=WD 6
TgeneTLE6chr19:3382241chr19:2980098ENST00000452088016540_5710450.0RepeatNote=WD 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFICchr19:3382241chr19:2980098ENST00000341919+291_195187429.0DNA bindingCTF/NF-I
HgeneNFICchr19:3382241chr19:2980098ENST00000346156+291_195178669.0DNA bindingCTF/NF-I
HgeneNFICchr19:3382241chr19:2980098ENST00000395111+2101_195178548.3333333333334DNA bindingCTF/NF-I
HgeneNFICchr19:3382241chr19:2980098ENST00000443272+2111_195187509.0DNA bindingCTF/NF-I
HgeneNFICchr19:3382241chr19:2980098ENST00000586919+281_195178407.0DNA bindingCTF/NF-I
HgeneNFICchr19:3382241chr19:2980098ENST00000589123+2111_195178500.0DNA bindingCTF/NF-I
HgeneNFICchr19:3382241chr19:2980098ENST00000590282+2101_195187461.6666666666667DNA bindingCTF/NF-I
HgeneNFICchr19:3382241chr19:2980098ENST00000341919+29404_412187429.0Motif9aaTAD
HgeneNFICchr19:3382241chr19:2980098ENST00000346156+29404_412178669.0Motif9aaTAD
HgeneNFICchr19:3382241chr19:2980098ENST00000395111+210404_412178548.3333333333334Motif9aaTAD
HgeneNFICchr19:3382241chr19:2980098ENST00000443272+211404_412187509.0Motif9aaTAD
HgeneNFICchr19:3382241chr19:2980098ENST00000586919+28404_412178407.0Motif9aaTAD
HgeneNFICchr19:3382241chr19:2980098ENST00000589123+211404_412178500.0Motif9aaTAD
HgeneNFICchr19:3382241chr19:2980098ENST00000590282+210404_412187461.6666666666667Motif9aaTAD


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Fusion Gene Sequence for NFIC-TLE6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>58927_58927_1_NFIC-TLE6_NFIC_chr19_3382241_ENST00000341919_TLE6_chr19_2980098_ENST00000482627_length(transcript)=958nt_BP=650nt
GGGGGGGCGGGGGGGTGGTTTGGAAAAATGACTCAGTAAGTTCAGCGCGCCCGCTCCGGCCGGCCCTGCGCCTCCCGCCGCGCCCGGGAT
GTATTCGTCCCCGCTCTGCCTCACCCAGGATGAGTTCCACCCGTTCATCGAGGCCCTGCTGCCTCACGTCCGCGCCTTCGCCTACACCTG
GTTCAACCTGCAGGCGCGGAAGCGCAAGTACTTCAAGAAGCACGAGAAGCGGATGTCGAAGGACGAGGAGCGTGCGGTCAAGGACGAGCT
GCTGGGCGAGAAGCCCGAGGTCAAGCAGAAGTGGGCGTCGCGGCTGCTGGCCAAGCTGCGCAAGGACATCCGGCCCGAGTGCCGCGAGGA
CTTCGTGCTGAGCATCACCGGCAAGAAGGCGCCGGGCTGCGTGCTCTCCAACCCCGACCAGAAGGGCAAGATGCGGCGCATCGACTGTCT
CCGGCAGGCGGACAAGGTGTGGCGGCTGGACCTGGTCATGGTCATCCTGTTCAAGGGCATCCCGCTGGAGAGCACCGACGGCGAGCGCCT
GGTCAAGGCTGCGCAGTGCGGTCACCCGGTCCTGTGCGTGCAGCCGCACCACATTGGCGTGGCCGTCAAGGAGCTGGACCTCTACCTGGC
CTACTTCGTGCGTGAGCGAGCCTTGTCCTGGGATCTCGAACTCTGAGAGCTCTCCGACGCTGAATTATCAGGGCATTCTAAATCGGCTCA
AGCAGTTCCCCAGGTGAGAGCAATTCCAGGGGCCGGAGGTCTCACGCTGGGAAGGAGCCCCACCTGGCCTCTCTCCCGGGGGTCCTAGTG
AGTGGTCTAGAGGCTGCTGGCCCAAGAGCCAGGCTCAGGAACAGGAAGCCATGCAGATACCCAGCATGGAGAACCCGGCAATACCCATCC

>58927_58927_1_NFIC-TLE6_NFIC_chr19_3382241_ENST00000341919_TLE6_chr19_2980098_ENST00000482627_length(amino acids)=195AA_BP=
MYSSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECRE
DFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYL

--------------------------------------------------------------
>58927_58927_2_NFIC-TLE6_NFIC_chr19_3382241_ENST00000346156_TLE6_chr19_2980098_ENST00000482627_length(transcript)=908nt_BP=600nt
CCCCCCCTCGCCGGGGACCGAGCGCGCTCGCTCCGGCGCCGGCCTCGCCTCCTCGCAGCAGCGCCATGGATGAGTTCCACCCGTTCATCG
AGGCCCTGCTGCCTCACGTCCGCGCCTTCGCCTACACCTGGTTCAACCTGCAGGCGCGGAAGCGCAAGTACTTCAAGAAGCACGAGAAGC
GGATGTCGAAGGACGAGGAGCGTGCGGTCAAGGACGAGCTGCTGGGCGAGAAGCCCGAGGTCAAGCAGAAGTGGGCGTCGCGGCTGCTGG
CCAAGCTGCGCAAGGACATCCGGCCCGAGTGCCGCGAGGACTTCGTGCTGAGCATCACCGGCAAGAAGGCGCCGGGCTGCGTGCTCTCCA
ACCCCGACCAGAAGGGCAAGATGCGGCGCATCGACTGTCTCCGGCAGGCGGACAAGGTGTGGCGGCTGGACCTGGTCATGGTCATCCTGT
TCAAGGGCATCCCGCTGGAGAGCACCGACGGCGAGCGCCTGGTCAAGGCTGCGCAGTGCGGTCACCCGGTCCTGTGCGTGCAGCCGCACC
ACATTGGCGTGGCCGTCAAGGAGCTGGACCTCTACCTGGCCTACTTCGTGCGTGAGCGAGCCTTGTCCTGGGATCTCGAACTCTGAGAGC
TCTCCGACGCTGAATTATCAGGGCATTCTAAATCGGCTCAAGCAGTTCCCCAGGTGAGAGCAATTCCAGGGGCCGGAGGTCTCACGCTGG
GAAGGAGCCCCACCTGGCCTCTCTCCCGGGGGTCCTAGTGAGTGGTCTAGAGGCTGCTGGCCCAAGAGCCAGGCTCAGGAACAGGAAGCC
ATGCAGATACCCAGCATGGAGAACCCGGCAATACCCATCCCAGCTTTTGATTAAACAAAATTACCAACAAATATTAAAATTTTGATTTTC

>58927_58927_2_NFIC-TLE6_NFIC_chr19_3382241_ENST00000346156_TLE6_chr19_2980098_ENST00000482627_length(amino acids)=186AA_BP=
MDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGK
KAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERAL

--------------------------------------------------------------
>58927_58927_3_NFIC-TLE6_NFIC_chr19_3382241_ENST00000395111_TLE6_chr19_2980098_ENST00000482627_length(transcript)=879nt_BP=571nt
GCTCCGGCGCCGGCCTCGCCTCCTCGCAGCAGCGCCATGGATGAGTTCCACCCGTTCATCGAGGCCCTGCTGCCTCACGTCCGCGCCTTC
GCCTACACCTGGTTCAACCTGCAGGCGCGGAAGCGCAAGTACTTCAAGAAGCACGAGAAGCGGATGTCGAAGGACGAGGAGCGTGCGGTC
AAGGACGAGCTGCTGGGCGAGAAGCCCGAGGTCAAGCAGAAGTGGGCGTCGCGGCTGCTGGCCAAGCTGCGCAAGGACATCCGGCCCGAG
TGCCGCGAGGACTTCGTGCTGAGCATCACCGGCAAGAAGGCGCCGGGCTGCGTGCTCTCCAACCCCGACCAGAAGGGCAAGATGCGGCGC
ATCGACTGTCTCCGGCAGGCGGACAAGGTGTGGCGGCTGGACCTGGTCATGGTCATCCTGTTCAAGGGCATCCCGCTGGAGAGCACCGAC
GGCGAGCGCCTGGTCAAGGCTGCGCAGTGCGGTCACCCGGTCCTGTGCGTGCAGCCGCACCACATTGGCGTGGCCGTCAAGGAGCTGGAC
CTCTACCTGGCCTACTTCGTGCGTGAGCGAGCCTTGTCCTGGGATCTCGAACTCTGAGAGCTCTCCGACGCTGAATTATCAGGGCATTCT
AAATCGGCTCAAGCAGTTCCCCAGGTGAGAGCAATTCCAGGGGCCGGAGGTCTCACGCTGGGAAGGAGCCCCACCTGGCCTCTCTCCCGG
GGGTCCTAGTGAGTGGTCTAGAGGCTGCTGGCCCAAGAGCCAGGCTCAGGAACAGGAAGCCATGCAGATACCCAGCATGGAGAACCCGGC

>58927_58927_3_NFIC-TLE6_NFIC_chr19_3382241_ENST00000395111_TLE6_chr19_2980098_ENST00000482627_length(amino acids)=186AA_BP=
MDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGK
KAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERAL

--------------------------------------------------------------
>58927_58927_4_NFIC-TLE6_NFIC_chr19_3382241_ENST00000443272_TLE6_chr19_2980098_ENST00000482627_length(transcript)=921nt_BP=613nt
AAGTTCAGCGCGCCCGCTCCGGCCGGCCCTGCGCCTCCCGCCGCGCCCGGGATGTATTCGTCCCCGCTCTGCCTCACCCAGGATGAGTTC
CACCCGTTCATCGAGGCCCTGCTGCCTCACGTCCGCGCCTTCGCCTACACCTGGTTCAACCTGCAGGCGCGGAAGCGCAAGTACTTCAAG
AAGCACGAGAAGCGGATGTCGAAGGACGAGGAGCGTGCGGTCAAGGACGAGCTGCTGGGCGAGAAGCCCGAGGTCAAGCAGAAGTGGGCG
TCGCGGCTGCTGGCCAAGCTGCGCAAGGACATCCGGCCCGAGTGCCGCGAGGACTTCGTGCTGAGCATCACCGGCAAGAAGGCGCCGGGC
TGCGTGCTCTCCAACCCCGACCAGAAGGGCAAGATGCGGCGCATCGACTGTCTCCGGCAGGCGGACAAGGTGTGGCGGCTGGACCTGGTC
ATGGTCATCCTGTTCAAGGGCATCCCGCTGGAGAGCACCGACGGCGAGCGCCTGGTCAAGGCTGCGCAGTGCGGTCACCCGGTCCTGTGC
GTGCAGCCGCACCACATTGGCGTGGCCGTCAAGGAGCTGGACCTCTACCTGGCCTACTTCGTGCGTGAGCGAGCCTTGTCCTGGGATCTC
GAACTCTGAGAGCTCTCCGACGCTGAATTATCAGGGCATTCTAAATCGGCTCAAGCAGTTCCCCAGGTGAGAGCAATTCCAGGGGCCGGA
GGTCTCACGCTGGGAAGGAGCCCCACCTGGCCTCTCTCCCGGGGGTCCTAGTGAGTGGTCTAGAGGCTGCTGGCCCAAGAGCCAGGCTCA
GGAACAGGAAGCCATGCAGATACCCAGCATGGAGAACCCGGCAATACCCATCCCAGCTTTTGATTAAACAAAATTACCAACAAATATTAA

>58927_58927_4_NFIC-TLE6_NFIC_chr19_3382241_ENST00000443272_TLE6_chr19_2980098_ENST00000482627_length(amino acids)=195AA_BP=
MYSSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECRE
DFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYL

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>58927_58927_5_NFIC-TLE6_NFIC_chr19_3382241_ENST00000586919_TLE6_chr19_2980098_ENST00000482627_length(transcript)=843nt_BP=535nt
ATGGATGAGTTCCACCCGTTCATCGAGGCCCTGCTGCCTCACGTCCGCGCCTTCGCCTACACCTGGTTCAACCTGCAGGCGCGGAAGCGC
AAGTACTTCAAGAAGCACGAGAAGCGGATGTCGAAGGACGAGGAGCGTGCGGTCAAGGACGAGCTGCTGGGCGAGAAGCCCGAGGTCAAG
CAGAAGTGGGCGTCGCGGCTGCTGGCCAAGCTGCGCAAGGACATCCGGCCCGAGTGCCGCGAGGACTTCGTGCTGAGCATCACCGGCAAG
AAGGCGCCGGGCTGCGTGCTCTCCAACCCCGACCAGAAGGGCAAGATGCGGCGCATCGACTGTCTCCGGCAGGCGGACAAGGTGTGGCGG
CTGGACCTGGTCATGGTCATCCTGTTCAAGGGCATCCCGCTGGAGAGCACCGACGGCGAGCGCCTGGTCAAGGCTGCGCAGTGCGGTCAC
CCGGTCCTGTGCGTGCAGCCGCACCACATTGGCGTGGCCGTCAAGGAGCTGGACCTCTACCTGGCCTACTTCGTGCGTGAGCGAGCCTTG
TCCTGGGATCTCGAACTCTGAGAGCTCTCCGACGCTGAATTATCAGGGCATTCTAAATCGGCTCAAGCAGTTCCCCAGGTGAGAGCAATT
CCAGGGGCCGGAGGTCTCACGCTGGGAAGGAGCCCCACCTGGCCTCTCTCCCGGGGGTCCTAGTGAGTGGTCTAGAGGCTGCTGGCCCAA
GAGCCAGGCTCAGGAACAGGAAGCCATGCAGATACCCAGCATGGAGAACCCGGCAATACCCATCCCAGCTTTTGATTAAACAAAATTACC

>58927_58927_5_NFIC-TLE6_NFIC_chr19_3382241_ENST00000586919_TLE6_chr19_2980098_ENST00000482627_length(amino acids)=186AA_BP=
MDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGK
KAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERAL

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>58927_58927_6_NFIC-TLE6_NFIC_chr19_3382241_ENST00000589123_TLE6_chr19_2980098_ENST00000482627_length(transcript)=963nt_BP=655nt
GCTCGCTCCCTCCCCCGCGCGCCCTCCCTCGCCGCCTCCTCCCGCCGCCTGCGGCCCCCCCCTCGCCGGGGACCGAGCGCGCTCGCTCCG
GCGCCGGCCTCGCCTCCTCGCAGCAGCGCCATGGATGAGTTCCACCCGTTCATCGAGGCCCTGCTGCCTCACGTCCGCGCCTTCGCCTAC
ACCTGGTTCAACCTGCAGGCGCGGAAGCGCAAGTACTTCAAGAAGCACGAGAAGCGGATGTCGAAGGACGAGGAGCGTGCGGTCAAGGAC
GAGCTGCTGGGCGAGAAGCCCGAGGTCAAGCAGAAGTGGGCGTCGCGGCTGCTGGCCAAGCTGCGCAAGGACATCCGGCCCGAGTGCCGC
GAGGACTTCGTGCTGAGCATCACCGGCAAGAAGGCGCCGGGCTGCGTGCTCTCCAACCCCGACCAGAAGGGCAAGATGCGGCGCATCGAC
TGTCTCCGGCAGGCGGACAAGGTGTGGCGGCTGGACCTGGTCATGGTCATCCTGTTCAAGGGCATCCCGCTGGAGAGCACCGACGGCGAG
CGCCTGGTCAAGGCTGCGCAGTGCGGTCACCCGGTCCTGTGCGTGCAGCCGCACCACATTGGCGTGGCCGTCAAGGAGCTGGACCTCTAC
CTGGCCTACTTCGTGCGTGAGCGAGCCTTGTCCTGGGATCTCGAACTCTGAGAGCTCTCCGACGCTGAATTATCAGGGCATTCTAAATCG
GCTCAAGCAGTTCCCCAGGTGAGAGCAATTCCAGGGGCCGGAGGTCTCACGCTGGGAAGGAGCCCCACCTGGCCTCTCTCCCGGGGGTCC
TAGTGAGTGGTCTAGAGGCTGCTGGCCCAAGAGCCAGGCTCAGGAACAGGAAGCCATGCAGATACCCAGCATGGAGAACCCGGCAATACC

>58927_58927_6_NFIC-TLE6_NFIC_chr19_3382241_ENST00000589123_TLE6_chr19_2980098_ENST00000482627_length(amino acids)=210AA_BP=
MRPPPRRGPSALAPAPASPPRSSAMDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASR
LLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQ

--------------------------------------------------------------
>58927_58927_7_NFIC-TLE6_NFIC_chr19_3382241_ENST00000590282_TLE6_chr19_2980098_ENST00000482627_length(transcript)=924nt_BP=616nt
AGTAAGTTCAGCGCGCCCGCTCCGGCCGGCCCTGCGCCTCCCGCCGCGCCCGGGATGTATTCGTCCCCGCTCTGCCTCACCCAGGATGAG
TTCCACCCGTTCATCGAGGCCCTGCTGCCTCACGTCCGCGCCTTCGCCTACACCTGGTTCAACCTGCAGGCGCGGAAGCGCAAGTACTTC
AAGAAGCACGAGAAGCGGATGTCGAAGGACGAGGAGCGTGCGGTCAAGGACGAGCTGCTGGGCGAGAAGCCCGAGGTCAAGCAGAAGTGG
GCGTCGCGGCTGCTGGCCAAGCTGCGCAAGGACATCCGGCCCGAGTGCCGCGAGGACTTCGTGCTGAGCATCACCGGCAAGAAGGCGCCG
GGCTGCGTGCTCTCCAACCCCGACCAGAAGGGCAAGATGCGGCGCATCGACTGTCTCCGGCAGGCGGACAAGGTGTGGCGGCTGGACCTG
GTCATGGTCATCCTGTTCAAGGGCATCCCGCTGGAGAGCACCGACGGCGAGCGCCTGGTCAAGGCTGCGCAGTGCGGTCACCCGGTCCTG
TGCGTGCAGCCGCACCACATTGGCGTGGCCGTCAAGGAGCTGGACCTCTACCTGGCCTACTTCGTGCGTGAGCGAGCCTTGTCCTGGGAT
CTCGAACTCTGAGAGCTCTCCGACGCTGAATTATCAGGGCATTCTAAATCGGCTCAAGCAGTTCCCCAGGTGAGAGCAATTCCAGGGGCC
GGAGGTCTCACGCTGGGAAGGAGCCCCACCTGGCCTCTCTCCCGGGGGTCCTAGTGAGTGGTCTAGAGGCTGCTGGCCCAAGAGCCAGGC
TCAGGAACAGGAAGCCATGCAGATACCCAGCATGGAGAACCCGGCAATACCCATCCCAGCTTTTGATTAAACAAAATTACCAACAAATAT

>58927_58927_7_NFIC-TLE6_NFIC_chr19_3382241_ENST00000590282_TLE6_chr19_2980098_ENST00000482627_length(amino acids)=195AA_BP=
MYSSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECRE
DFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NFIC-TLE6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NFIC-TLE6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NFIC-TLE6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource