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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NFIX-RAD23A (FusionGDB2 ID:58955)

Fusion Gene Summary for NFIX-RAD23A

Fusion gene summary

Fusion gene information	Fusion gene name: NFIX-RAD23A
	Fusion gene ID: 58955
		Hgene	Tgene
	Gene symbol	NFIX	RAD23A
	Gene ID	4784	5886
	Gene name	nuclear factor I X	RAD23 homolog A, nucleotide excision repair protein
	Synonyms	CTF\|MRSHSS\|NF-I/X\|NF1-X\|NF1A\|SOTOS2	HHR23A\|HR23A
	Cytomap	19p13.13	19p13.13
	Type of gene	protein-coding	protein-coding
	Description	nuclear factor 1 X-typeCCAAT-box-binding transcription factorTGGCA-binding proteinnuclear factor 1/X	UV excision repair protein RAD23 homolog ARAD23, yeast homolog, A
	Modification date	20200329	20200322
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000358552, ENST00000360105, ENST00000397661, ENST00000585575, ENST00000587260, ENST00000587760, ENST00000588228, ENST00000592199, ENST00000588680,	ENST00000588826, ENST00000316856, ENST00000541222, ENST00000586534, ENST00000592268,
Fusion gene scores	* DoF score	27 X 14 X 16=6048	13 X 9 X 9=1053
	# samples	42	15
	** MAII score	log2(42/6048*10)=-3.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/1053*10)=-2.81147103052984 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NFIX [Title/Abstract] AND RAD23A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NFIX(13106678)-RAD23A(13063503), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NFIX	GO:0000122	negative regulation of transcription by RNA polymerase II	19706729
Hgene	NFIX	GO:0045944	positive regulation of transcription by RNA polymerase II	19706729
Tgene	RAD23A	GO:0006289	nucleotide-excision repair	9372924
Tgene	RAD23A	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	12643283

Fusion gene breakpoints across NFIX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RAD23A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AN-A0G0-01A	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
ChimerDB4	BRCA	TCGA-C8-A26Y-01A	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
ChimerDB4	LIHC	TCGA-BC-A10T-01A	NFIX	chr19	13106678	-	RAD23A	chr19	13063503	+
ChimerDB4	LIHC	TCGA-BC-A10T-01A	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+

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Fusion Gene ORF analysis for NFIX-RAD23A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000358552	ENST00000588826	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
5CDS-3UTR	ENST00000360105	ENST00000588826	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
5CDS-3UTR	ENST00000397661	ENST00000588826	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-3UTR	ENST00000397661	ENST00000588826	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
5CDS-3UTR	ENST00000585575	ENST00000588826	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-3UTR	ENST00000585575	ENST00000588826	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
5CDS-3UTR	ENST00000587260	ENST00000588826	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-3UTR	ENST00000587260	ENST00000588826	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
5CDS-3UTR	ENST00000587760	ENST00000588826	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-3UTR	ENST00000587760	ENST00000588826	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
5CDS-3UTR	ENST00000588228	ENST00000588826	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-3UTR	ENST00000588228	ENST00000588826	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
5CDS-3UTR	ENST00000592199	ENST00000588826	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-3UTR	ENST00000592199	ENST00000588826	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
5CDS-5UTR	ENST00000397661	ENST00000316856	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-5UTR	ENST00000397661	ENST00000541222	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-5UTR	ENST00000397661	ENST00000586534	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-5UTR	ENST00000397661	ENST00000592268	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-5UTR	ENST00000585575	ENST00000316856	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-5UTR	ENST00000585575	ENST00000541222	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-5UTR	ENST00000585575	ENST00000586534	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-5UTR	ENST00000585575	ENST00000592268	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-5UTR	ENST00000587260	ENST00000316856	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-5UTR	ENST00000587260	ENST00000541222	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-5UTR	ENST00000587260	ENST00000586534	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-5UTR	ENST00000587260	ENST00000592268	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-5UTR	ENST00000587760	ENST00000316856	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-5UTR	ENST00000587760	ENST00000541222	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-5UTR	ENST00000587760	ENST00000586534	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-5UTR	ENST00000587760	ENST00000592268	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-5UTR	ENST00000588228	ENST00000316856	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-5UTR	ENST00000588228	ENST00000541222	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-5UTR	ENST00000588228	ENST00000586534	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-5UTR	ENST00000588228	ENST00000592268	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-5UTR	ENST00000592199	ENST00000316856	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-5UTR	ENST00000592199	ENST00000541222	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-5UTR	ENST00000592199	ENST00000586534	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-5UTR	ENST00000592199	ENST00000592268	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
5CDS-intron	ENST00000397661	ENST00000588826	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
5CDS-intron	ENST00000397661	ENST00000592268	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
5CDS-intron	ENST00000592199	ENST00000588826	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
5CDS-intron	ENST00000592199	ENST00000592268	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
In-frame	ENST00000358552	ENST00000316856	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000358552	ENST00000541222	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000358552	ENST00000586534	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000358552	ENST00000592268	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000360105	ENST00000316856	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000360105	ENST00000541222	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000360105	ENST00000586534	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000360105	ENST00000592268	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000397661	ENST00000316856	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000397661	ENST00000316856	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
In-frame	ENST00000397661	ENST00000541222	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000397661	ENST00000541222	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
In-frame	ENST00000397661	ENST00000586534	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000397661	ENST00000586534	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
In-frame	ENST00000397661	ENST00000592268	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000585575	ENST00000316856	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000585575	ENST00000541222	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000585575	ENST00000586534	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000585575	ENST00000592268	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000587260	ENST00000316856	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000587260	ENST00000541222	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000587260	ENST00000586534	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000587260	ENST00000592268	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000587760	ENST00000316856	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000587760	ENST00000541222	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000587760	ENST00000586534	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000587760	ENST00000592268	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000588228	ENST00000316856	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000588228	ENST00000541222	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000588228	ENST00000586534	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000588228	ENST00000592268	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000592199	ENST00000316856	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000592199	ENST00000316856	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
In-frame	ENST00000592199	ENST00000541222	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000592199	ENST00000541222	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
In-frame	ENST00000592199	ENST00000586534	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
In-frame	ENST00000592199	ENST00000586534	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
In-frame	ENST00000592199	ENST00000592268	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
intron-3CDS	ENST00000358552	ENST00000316856	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-3CDS	ENST00000358552	ENST00000541222	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-3CDS	ENST00000358552	ENST00000586534	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-3CDS	ENST00000360105	ENST00000316856	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-3CDS	ENST00000360105	ENST00000541222	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-3CDS	ENST00000360105	ENST00000586534	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-3CDS	ENST00000585575	ENST00000316856	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-3CDS	ENST00000585575	ENST00000541222	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-3CDS	ENST00000585575	ENST00000586534	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-3CDS	ENST00000587260	ENST00000316856	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-3CDS	ENST00000587260	ENST00000541222	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-3CDS	ENST00000587260	ENST00000586534	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-3CDS	ENST00000587760	ENST00000316856	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-3CDS	ENST00000587760	ENST00000541222	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-3CDS	ENST00000587760	ENST00000586534	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-3CDS	ENST00000588228	ENST00000316856	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-3CDS	ENST00000588228	ENST00000541222	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-3CDS	ENST00000588228	ENST00000586534	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-3CDS	ENST00000588680	ENST00000316856	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
intron-3CDS	ENST00000588680	ENST00000316856	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-3CDS	ENST00000588680	ENST00000541222	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
intron-3CDS	ENST00000588680	ENST00000541222	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-3CDS	ENST00000588680	ENST00000586534	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
intron-3CDS	ENST00000588680	ENST00000586534	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-3CDS	ENST00000588680	ENST00000592268	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
intron-3UTR	ENST00000358552	ENST00000588826	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
intron-3UTR	ENST00000360105	ENST00000588826	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
intron-3UTR	ENST00000588680	ENST00000588826	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
intron-3UTR	ENST00000588680	ENST00000588826	NFIX	chr19	13136366	+	RAD23A	chr19	13060089	+
intron-5UTR	ENST00000358552	ENST00000316856	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
intron-5UTR	ENST00000358552	ENST00000541222	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
intron-5UTR	ENST00000358552	ENST00000586534	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
intron-5UTR	ENST00000358552	ENST00000592268	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
intron-5UTR	ENST00000360105	ENST00000316856	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
intron-5UTR	ENST00000360105	ENST00000541222	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
intron-5UTR	ENST00000360105	ENST00000586534	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
intron-5UTR	ENST00000360105	ENST00000592268	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
intron-5UTR	ENST00000588680	ENST00000316856	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
intron-5UTR	ENST00000588680	ENST00000541222	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
intron-5UTR	ENST00000588680	ENST00000586534	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
intron-5UTR	ENST00000588680	ENST00000592268	NFIX	chr19	13189549	+	RAD23A	chr19	13058662	+
intron-intron	ENST00000358552	ENST00000588826	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-intron	ENST00000358552	ENST00000592268	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-intron	ENST00000360105	ENST00000588826	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-intron	ENST00000360105	ENST00000592268	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-intron	ENST00000585575	ENST00000588826	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-intron	ENST00000585575	ENST00000592268	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-intron	ENST00000587260	ENST00000588826	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-intron	ENST00000587260	ENST00000592268	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-intron	ENST00000587760	ENST00000588826	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-intron	ENST00000587760	ENST00000592268	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-intron	ENST00000588228	ENST00000588826	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-intron	ENST00000588228	ENST00000592268	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-intron	ENST00000588680	ENST00000588826	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+
intron-intron	ENST00000588680	ENST00000592268	NFIX	chr19	13106678	+	RAD23A	chr19	13063503	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for NFIX-RAD23A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
NFIX	chr19	13189549	+	RAD23A	chr19	13058661	+	0.7012192	0.2987808
NFIX	chr19	13136366	+	RAD23A	chr19	13060091	+	0.002177571	0.9978224
NFIX	chr19	13106678	+	RAD23A	chr19	13063502	+	4.04E-19	1
NFIX	chr19	13189549	+	RAD23A	chr19	13058661	+	0.7012192	0.2987808
NFIX	chr19	13136366	+	RAD23A	chr19	13060091	+	0.002177571	0.9978224
NFIX	chr19	13106678	+	RAD23A	chr19	13063502	+	4.04E-19	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NFIX-RAD23A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:13106678/chr19:13063503)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RAD23A

chr19:13106678

chr19:13063503

ENST00000586534

318_358

271

364.0

Domain

UBA 2

Tgene

RAD23A

chr19:13106678

chr19:13063503

ENST00000592268

161_201

309.0

Domain

UBA 1

Tgene

RAD23A

chr19:13106678

chr19:13063503

ENST00000592268

1_81

309.0

Domain

Ubiquitin-like

Tgene

RAD23A

chr19:13106678

chr19:13063503

ENST00000592268

318_358

309.0

Domain

UBA 2

Tgene

RAD23A

chr19:13136366

chr19:13060089

ENST00000586534

318_358

226

364.0

Domain

UBA 2

Tgene

RAD23A

chr19:13136366

chr19:13060089

ENST00000592268

318_358

226

309.0

Domain

UBA 2

Tgene

RAD23A

chr19:13106678

chr19:13063503

ENST00000586534

319_363

271

364.0

Region

Note=HIV-1 vpr binding

Tgene

RAD23A

chr19:13106678

chr19:13063503

ENST00000592268

319_363

309.0

Region

Note=HIV-1 vpr binding

Tgene

RAD23A

chr19:13136366

chr19:13060089

ENST00000586534

319_363

226

364.0

Region

Note=HIV-1 vpr binding

Tgene

RAD23A

chr19:13136366

chr19:13060089

ENST00000592268

319_363

226

309.0

Region

Note=HIV-1 vpr binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NFIX

chr19:13106678

chr19:13063503

ENST00000397661

1_194

878.6666666666666

DNA binding

CTF/NF-I

Hgene

NFIX

chr19:13106678

chr19:13063503

ENST00000585575

1_194

495.0

DNA binding

CTF/NF-I

Hgene

NFIX

chr19:13106678

chr19:13063503

ENST00000587260

1_194

281.6666666666667

DNA binding

CTF/NF-I

Hgene

NFIX

chr19:13106678

chr19:13063503

ENST00000587760

1_194

460.6666666666667

DNA binding

CTF/NF-I

Hgene

NFIX

chr19:13106678

chr19:13063503

ENST00000592199

1_194

503.0

DNA binding

CTF/NF-I

Hgene

NFIX

chr19:13136366

chr19:13060089

ENST00000397661

1_194

186

878.6666666666666

DNA binding

CTF/NF-I

Hgene

NFIX

chr19:13136366

chr19:13060089

ENST00000585575

1_194

178

495.0

DNA binding

CTF/NF-I

Hgene

NFIX

chr19:13136366

chr19:13060089

ENST00000587260

1_194

185

281.6666666666667

DNA binding

CTF/NF-I

Hgene

NFIX

chr19:13136366

chr19:13060089

ENST00000587760

1_194

178

460.6666666666667

DNA binding

CTF/NF-I

Hgene

NFIX

chr19:13136366

chr19:13060089

ENST00000592199

1_194

186

503.0

DNA binding

CTF/NF-I

Hgene

NFIX

chr19:13106678

chr19:13063503

ENST00000397661

398_406

878.6666666666666

Motif

9aaTAD

Hgene

NFIX

chr19:13106678

chr19:13063503

ENST00000585575

398_406

495.0

Motif

9aaTAD

Hgene

NFIX

chr19:13106678

chr19:13063503

ENST00000587260

398_406

281.6666666666667

Motif

9aaTAD

Hgene

NFIX

chr19:13106678

chr19:13063503

ENST00000587760

398_406

460.6666666666667

Motif

9aaTAD

Hgene

NFIX

chr19:13106678

chr19:13063503

ENST00000592199

398_406

503.0

Motif

9aaTAD

Hgene

NFIX

chr19:13136366

chr19:13060089

ENST00000397661

398_406

186

878.6666666666666

Motif

9aaTAD

Hgene

NFIX

chr19:13136366

chr19:13060089

ENST00000585575

398_406

178

495.0

Motif

9aaTAD

Hgene

NFIX

chr19:13136366

chr19:13060089

ENST00000587260

398_406

185

281.6666666666667

Motif

9aaTAD

Hgene

NFIX

chr19:13136366

chr19:13060089

ENST00000587760

398_406

178

460.6666666666667

Motif

9aaTAD

Hgene

NFIX

chr19:13136366

chr19:13060089

ENST00000592199

398_406

186

503.0

Motif

9aaTAD

Tgene

RAD23A

chr19:13106678

chr19:13063503

ENST00000586534

161_201

271

364.0

Domain

UBA 1

Tgene

RAD23A

chr19:13106678

chr19:13063503

ENST00000586534

1_81

271

364.0

Domain

Ubiquitin-like

Tgene

RAD23A

chr19:13136366

chr19:13060089

ENST00000586534

161_201

226

364.0

Domain

UBA 1

Tgene

RAD23A

chr19:13136366

chr19:13060089

ENST00000586534

1_81

226

364.0

Domain

Ubiquitin-like

Tgene

RAD23A

chr19:13136366

chr19:13060089

ENST00000592268

161_201

226

309.0

Domain

UBA 1

Tgene

RAD23A

chr19:13136366

chr19:13060089

ENST00000592268

1_81

226

309.0

Domain

Ubiquitin-like

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Fusion Gene Sequence for NFIX-RAD23A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NFIX-RAD23A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for NFIX-RAD23A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for NFIX-RAD23A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source