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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NFS1-TGIF2 (FusionGDB2 ID:59000)

Fusion Gene Summary for NFS1-TGIF2

check button Fusion gene summary
Fusion gene informationFusion gene name: NFS1-TGIF2
Fusion gene ID: 59000
HgeneTgene
Gene symbol

NFS1

TGIF2

Gene ID

9054

60436

Gene nameNFS1 cysteine desulfuraseTGFB induced factor homeobox 2
SynonymsHUSSY-08|IscS|NIFS-
Cytomap

20q11.22

20q11.23

Type of geneprotein-codingprotein-coding
Descriptioncysteine desulfurase, mitochondrialNFS1 nitrogen fixation 1 homolognitrogen fixation 1 (S. cerevisiae, homolog)nitrogen-fixing bacteria S-like proteinhomeobox protein TGIF25'-TG-3' interacting factor 2TGF(beta)-induced transcription factor 2TGFB-induced factor 2 (TALE family homeobox)transcription growth factor-beta-induced factor 2
Modification date2020031320200329
UniProtAcc

Q9Y697

.
Ensembl transtripts involved in fusion geneENST00000374085, ENST00000397425, 
ENST00000540053, ENST00000374092, 
ENST00000541387, ENST00000306750, 
ENST00000498084, 		ENST00000373872, 
ENST00000373874, 
Fusion gene scores* DoF score4 X 5 X 3=607 X 3 X 7=147
# samples 47
** MAII scorelog2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NFS1 [Title/Abstract] AND TGIF2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNFS1(34268659)-TGIF2(35219313), # samples:1
Anticipated loss of major functional domain due to fusion event.NFS1-TGIF2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NFS1-TGIF2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NFS1-TGIF2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
NFS1-TGIF2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFS1

GO:0018283

iron incorporation into metallo-sulfur cluster

16847322


check buttonFusion gene breakpoints across NFS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TGIF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4READTCGA-AG-3587NFS1chr20

34268659

-TGIF2chr20

35219313

+


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Fusion Gene ORF analysis for NFS1-TGIF2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000374085ENST00000373872NFS1chr20

34268659

-TGIF2chr20

35219313

+
Frame-shiftENST00000374085ENST00000373874NFS1chr20

34268659

-TGIF2chr20

35219313

+
Frame-shiftENST00000397425ENST00000373872NFS1chr20

34268659

-TGIF2chr20

35219313

+
Frame-shiftENST00000397425ENST00000373874NFS1chr20

34268659

-TGIF2chr20

35219313

+
Frame-shiftENST00000540053ENST00000373872NFS1chr20

34268659

-TGIF2chr20

35219313

+
Frame-shiftENST00000540053ENST00000373874NFS1chr20

34268659

-TGIF2chr20

35219313

+
In-frameENST00000374092ENST00000373872NFS1chr20

34268659

-TGIF2chr20

35219313

+
In-frameENST00000374092ENST00000373874NFS1chr20

34268659

-TGIF2chr20

35219313

+
In-frameENST00000541387ENST00000373872NFS1chr20

34268659

-TGIF2chr20

35219313

+
In-frameENST00000541387ENST00000373874NFS1chr20

34268659

-TGIF2chr20

35219313

+
intron-3CDSENST00000306750ENST00000373872NFS1chr20

34268659

-TGIF2chr20

35219313

+
intron-3CDSENST00000306750ENST00000373874NFS1chr20

34268659

-TGIF2chr20

35219313

+
intron-3CDSENST00000498084ENST00000373872NFS1chr20

34268659

-TGIF2chr20

35219313

+
intron-3CDSENST00000498084ENST00000373874NFS1chr20

34268659

-TGIF2chr20

35219313

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000374092NFS1chr2034268659-ENST00000373874TGIF2chr2035219313+390286132868278
ENST00000374092NFS1chr2034268659-ENST00000373872TGIF2chr2035219313+390286132868278
ENST00000541387NFS1chr2034268659-ENST00000373874TGIF2chr2035219313+374270125708227
ENST00000541387NFS1chr2034268659-ENST00000373872TGIF2chr2035219313+374270125708227

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000374092ENST00000373874NFS1chr2034268659-TGIF2chr2035219313+0.0042866510.99571335
ENST00000374092ENST00000373872NFS1chr2034268659-TGIF2chr2035219313+0.0042866510.99571335
ENST00000541387ENST00000373874NFS1chr2034268659-TGIF2chr2035219313+0.0033403910.99665964
ENST00000541387ENST00000373872NFS1chr2034268659-TGIF2chr2035219313+0.0033403910.99665964

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Fusion Genomic Features for NFS1-TGIF2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NFS1chr2034268658-TGIF2chr2035219312+1.83E-091
NFS1chr2034268658-TGIF2chr2035219312+1.83E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NFS1-TGIF2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:34268659/chr20:35219313)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFS1

Q9Y697

.
FUNCTION: Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor. {ECO:0000269|PubMed:18650437}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFS1chr20:34268659chr20:35219313ENST00000374085-713127_128203398.0RegionPyridoxal phosphate binding
HgeneNFS1chr20:34268659chr20:35219313ENST00000374092-713127_128263458.0RegionPyridoxal phosphate binding
HgeneNFS1chr20:34268659chr20:35219313ENST00000374092-713255_257263458.0RegionPyridoxal phosphate binding
HgeneNFS1chr20:34268659chr20:35219313ENST00000397425-713127_128203398.0RegionPyridoxal phosphate binding
HgeneNFS1chr20:34268659chr20:35219313ENST00000541387-612127_128212407.0RegionPyridoxal phosphate binding
TgeneTGIF2chr20:34268659chr20:35219313ENST0000037387213103_23764238.0RegionNote=Repressive function
TgeneTGIF2chr20:34268659chr20:35219313ENST0000037387413103_23764238.0RegionNote=Repressive function

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFS1chr20:34268659chr20:35219313ENST00000374085-713255_257203398.0RegionPyridoxal phosphate binding
HgeneNFS1chr20:34268659chr20:35219313ENST00000397425-713255_257203398.0RegionPyridoxal phosphate binding
HgeneNFS1chr20:34268659chr20:35219313ENST00000541387-612255_257212407.0RegionPyridoxal phosphate binding
TgeneTGIF2chr20:34268659chr20:35219313ENST000003738721316_7964238.0DNA bindingHomeobox%3B TALE-type
TgeneTGIF2chr20:34268659chr20:35219313ENST000003738741316_7964238.0DNA bindingHomeobox%3B TALE-type


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Fusion Gene Sequence for NFS1-TGIF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>59000_59000_1_NFS1-TGIF2_NFS1_chr20_34268659_ENST00000374092_TGIF2_chr20_35219313_ENST00000373872_length(transcript)=3902nt_BP=861nt
GGGCAGCACTTCCGGGAGCCTGGGGCCCAGGACTGCAGCGGCTTCGGAAGGTGGGCTCTGCCAGCGGGACCATGCTGCTCCGAGCCGCTT
GGAGGCGGGCGGCAGTGGCGGTGACAGCGGCTCCAGGGCCGAAGCCCGCGGCGCCCACTCGGGGGCTGCGCCTGCGCGTTGGAGACCGTG
CTCCTCAGTCTGCGGTTCCCGCAGATACAGCCGCTGCCCCGGAGGTGGGGCCAGTGCTGCGACCTCTCTATATGGATGTGCAAGCTACAA
CTCCTCTGGACCCCCGGGTGCTTGATGCCATGCTCCCTTACCTAATCAACTACTATGGGAACCCACACTCCCGGACACATGCTTATGGCT
GGGAGAGTGAGGCAGCCATGGAACGTGCTCGTCAGCAAGTAGCATCTCTGATTGGAGCTGATCCTCGTGAGATCATTTTTACTAGTGGTG
CTACTGAATCCAACAACATAGCAATTAAGGGGGTGGCCCGATTCTACAGGTCACGGAAAAAGCACTTGATCACCACCCAGACAGAACACA
AATGTGTCTTGGACTCCTGCCGTTCACTGGAAGCTGAGGGCTTTCAGGTCACCTACCTCCCAGTGCAGAAGAGTGGGATCATTGACCTAA
AGGAACTAGAGGCTGCTATCCAGCCAGATACTAGCCTGGTGTCAGTCATGACTGTGAACAATGAGATTGGAGTGAAGCAGCCTATTGCAG
AAATAGGGCGGATTTGCAGTTCCAGAAAGGTATATTTCCATACTGATGCAGCCCAGGCTGTTGGAAAAATCCCACTTGATGTCAATGACA
TGAAAATTGATCTCATGAGCATTAGTGGTCACAAAATCTACGGTCCCAAAGATATGTAACTGGTTCATCAATGCCCGGCGGCGGCTTCTC
CCAGACATGCTTCGGAAGGATGGCAAAGACCCTAATCAGTTTACCATTTCCCGCCGCGGGGGTAAGGCCTCAGATGTGGCCCTCCCCCGT
GGCAGCAGCCCCTCAGTGCTGGCTGTGTCTGTCCCAGCCCCCACCAATGTGCTCTCCCTGTCTGTGTGCTCCATGCCGCTTCACTCAGGC
CAGGGGGAAAAGCCAGCAGCCCCTTTCCCACGTGGGGAGCTGGAGTCTCCCAAGCCCCTGGTGACCCCTGGTAGCACACTTACTCTGCTG
ACCAGGGCTGAGGCTGGAAGCCCCACAGGTGGACTCTTCAACACGCCACCACCCACACCCCCAGAGCAGGACAAAGAGGACTTCAGCAGC
TTCCAGCTGCTGGTGGAGGTGGCGCTACAGAGGGCTGCTGAGATGGAGCTTCAGAAGCAGCAGGACCCATCACTCCCATTACTGCACACT
CCCATCCCTTTAGTCTCTGAAAATCCCCAGTAGGCATCTGCCAAGAAGGGTGCTGAAGGCTCCAGCCAGCTGTCCTGGGTTTCCGTTTTG
GTTCCCTTTCATACAGAGGGTTTTCTATGGATCACTGCCAAACATTGGGATCATCTCCTCTGTCCAGAGGTCTTCAACAGGAAGATGCCA
GCTGGCACCACTGCACTGTGATGGGGGCCCTCTCCTCTGCTGACTCTGCCGTTTCTCCAGGCCTCCGCTCAGTGATGAGACCAAGAGATC
GGAGACAAGCATGGTGCTGCTGCTTCTGCTGCTTCTCCAGAAAATCCCTGGGACACCTTTGTTCCAGCCTGGTTTCCTGGGCTGGGCTCA
GGAAAGCTGCCAAATTCAGTCCTATGTTGGGTCCAAGCTGCCCCTGTGCTGTTTCTGTCAAGCCAGGTGTGGACATTCCAAGTTCATATG
CGTGAACAAAAGAAAAGAGGAACCCAGTGGATGTAACAGAACCGACTCCAGTTGAATGTTTAGATTTTTGCTAAACTGTTTTCTTTTTCC
CTTTTTTGCTGTGGTTTGCATTCACGGCAGTAGTTAGCCCAGGTGTGGGGAACGAGAGTGCACTGCATGATAGCGTTCTGGTGAGCTGGG
AAGGACCCACCACTGCCACTGAGGATTGTTTTGGAAGAAAGGAATATTTTTATCTTGGGGACCAGCTAAGTCTCTGCAGTAGTGTGAAAT
TCCAAATGGTTGTTTTATCATTGGTTTGGTTTACCAAAAAAAAGGCAGGGAAAAAAAAAAAAAACAACCGTATGAGCGCATTGGCTTGTC
TGCCGCAGGCACAGAAGGGTAGAAAGCCACAGCAGGGGGCAGTCCAGCAGACTCTGACTCAACTTTCTAGGCACCTAGCAGAGAAAGATA
AGATCAAAAGGTGTTTGGTTTTTCTTTTAATTTTTATTGTAGTTTTTTTGGGTGGGTGGGGGAAGTAAACTAGACTGAAGCGATGGATTT
TTTTTTTCTTTTTTTTCTTTAGTGTTTTTCCCTTTGTTCTTGAACACTTTTGCCCTGCAGCCTCAGTTTTGAATTCTTTTAGCAACTTGG
ATTAGAGGGGCCCATATGTCAGAAGCTCCCAGCACCTCCTACTTGGGAGAAAAGTGAGCCATCTGCTGGTCAGGAAGTCCTCCAGAGAGG
CAGCTTTTCCCACAATGGTGGCAGGAAACTTTGGGGAAAGCAGGAATGGTGTCCACTGCTGCGGAGGAACTGCCTTCAGAGAAGGTGGGG
CTGGAAAAGGGTTAGAAGCCTCCTAGCTGGGATTGTCTTTGTTTCACCTTTCTTTAAATTAGAATTACAGAAGCCCCTGCCCAGTGAACA
GATAACGATTGGTCTTATGCTCCTCCCTTTCCCCCATTTTTTCTTTTGCTGTTTTGTTTTTTGTTTTTTGTTTGTTTGTTTGTTTTTTTG
AGACAGAGTCATGCTCTGTCACCCGGGCTGGAGTGCAGTGGTGCGATCTCAGCTCACTGTAACCTCCGCCTCCCGGGTTCAAGCAATTAT
TTGCCTCAGCCTCCCGAGTAGCTGGGATTATAGGCACCCGCCACCATGTCTGGCTTTTAGTAGAGACGGGGTTTCACCATCTTGGCCAGG
CTGGTCTTGGAACTCCTGACCTCGTGAGCCACCACGCCCAGCCTCTTTTGCTGTTTCATTGCTGACAGTGTTCAACAATATGCCCCATCT
TTATATATCCTAAGAAACACTAATCCTAGGTTATTGCTAGCCAAAATATTTTTGTCCTGAGTAGTGTCACTGGGCCAAAAGATAGATCAG
GACGACAGCCTTTAGTTTTCCTGAAATCACCAGGTCAGGCACAAGGAGAAAAGGTTCCTGGATACTGACTAACTTGGGTGGGTGGATCTA
GCCAGGAGAAAGACAGTAACATGTGTTCTGTACTTTCTGGGAAGATCCCTGAAGCCATCACAGAGGCTCCCCAACTTCTGAGTCGCCCAT
CTGTTGCTGTGGGAGTGTGAACGGATCGCTGAAGGAGAGGGAGCTTTGCTCTCTCTAGGTGGGCAAGTTTCCTGGGCTCTCTGTGTTGCC
TCCCTCTGGCTTCTTCCTCCCGTGCCCTCTCCCCGTGTGCCCCAGGGGGATCAGGGATCCTCACCCTCCTGAGGCCCAGTGGGGAAGAAT
GAACATGGCTTCATCCAGGTTAACTGATGCTGCCATTTGCCCAGCCTCTTCCATCCCAGCCCTGTCAGTGAGCCCAGGTCTGGTGCAACT
GCTGCAGGATGCCTGTAGTAGGGAACTCTGGAAGTGTATTGGGCTGAGGTGGGATTTTCCCTCCCCACAGTGCACTGAGCAATGGAGGGT
GGTGAGGGAGCCATGCTGCTGAATTCTGGTTGGCATTTCCCCATTATGTAAAATGGGGTGTTGGGTAGGGCAGACTCTGCTTGGGTTTGG
TTGTAAGATAAACCTGGAGGAGAAGCACAGTTGTCCCATTGAATTATTTGAGCAAAAACTACTGTAAATAACTTTTTTGTCTTTTGTCAA

>59000_59000_1_NFS1-TGIF2_NFS1_chr20_34268659_ENST00000374092_TGIF2_chr20_35219313_ENST00000373872_length(amino acids)=278AA_BP=
MQRLRKVGSASGTMLLRAAWRRAAVAVTAAPGPKPAAPTRGLRLRVGDRAPQSAVPADTAAAPEVGPVLRPLYMDVQATTPLDPRVLDAM
LPYLINYYGNPHSRTHAYGWESEAAMERARQQVASLIGADPREIIFTSGATESNNIAIKGVARFYRSRKKHLITTQTEHKCVLDSCRSLE
AEGFQVTYLPVQKSGIIDLKELEAAIQPDTSLVSVMTVNNEIGVKQPIAEIGRICSSRKVYFHTDAAQAVGKIPLDVNDMKIDLMSISGH

--------------------------------------------------------------
>59000_59000_2_NFS1-TGIF2_NFS1_chr20_34268659_ENST00000374092_TGIF2_chr20_35219313_ENST00000373874_length(transcript)=3902nt_BP=861nt
GGGCAGCACTTCCGGGAGCCTGGGGCCCAGGACTGCAGCGGCTTCGGAAGGTGGGCTCTGCCAGCGGGACCATGCTGCTCCGAGCCGCTT
GGAGGCGGGCGGCAGTGGCGGTGACAGCGGCTCCAGGGCCGAAGCCCGCGGCGCCCACTCGGGGGCTGCGCCTGCGCGTTGGAGACCGTG
CTCCTCAGTCTGCGGTTCCCGCAGATACAGCCGCTGCCCCGGAGGTGGGGCCAGTGCTGCGACCTCTCTATATGGATGTGCAAGCTACAA
CTCCTCTGGACCCCCGGGTGCTTGATGCCATGCTCCCTTACCTAATCAACTACTATGGGAACCCACACTCCCGGACACATGCTTATGGCT
GGGAGAGTGAGGCAGCCATGGAACGTGCTCGTCAGCAAGTAGCATCTCTGATTGGAGCTGATCCTCGTGAGATCATTTTTACTAGTGGTG
CTACTGAATCCAACAACATAGCAATTAAGGGGGTGGCCCGATTCTACAGGTCACGGAAAAAGCACTTGATCACCACCCAGACAGAACACA
AATGTGTCTTGGACTCCTGCCGTTCACTGGAAGCTGAGGGCTTTCAGGTCACCTACCTCCCAGTGCAGAAGAGTGGGATCATTGACCTAA
AGGAACTAGAGGCTGCTATCCAGCCAGATACTAGCCTGGTGTCAGTCATGACTGTGAACAATGAGATTGGAGTGAAGCAGCCTATTGCAG
AAATAGGGCGGATTTGCAGTTCCAGAAAGGTATATTTCCATACTGATGCAGCCCAGGCTGTTGGAAAAATCCCACTTGATGTCAATGACA
TGAAAATTGATCTCATGAGCATTAGTGGTCACAAAATCTACGGTCCCAAAGATATGTAACTGGTTCATCAATGCCCGGCGGCGGCTTCTC
CCAGACATGCTTCGGAAGGATGGCAAAGACCCTAATCAGTTTACCATTTCCCGCCGCGGGGGTAAGGCCTCAGATGTGGCCCTCCCCCGT
GGCAGCAGCCCCTCAGTGCTGGCTGTGTCTGTCCCAGCCCCCACCAATGTGCTCTCCCTGTCTGTGTGCTCCATGCCGCTTCACTCAGGC
CAGGGGGAAAAGCCAGCAGCCCCTTTCCCACGTGGGGAGCTGGAGTCTCCCAAGCCCCTGGTGACCCCTGGTAGCACACTTACTCTGCTG
ACCAGGGCTGAGGCTGGAAGCCCCACAGGTGGACTCTTCAACACGCCACCACCCACACCCCCAGAGCAGGACAAAGAGGACTTCAGCAGC
TTCCAGCTGCTGGTGGAGGTGGCGCTACAGAGGGCTGCTGAGATGGAGCTTCAGAAGCAGCAGGACCCATCACTCCCATTACTGCACACT
CCCATCCCTTTAGTCTCTGAAAATCCCCAGTAGGCATCTGCCAAGAAGGGTGCTGAAGGCTCCAGCCAGCTGTCCTGGGTTTCCGTTTTG
GTTCCCTTTCATACAGAGGGTTTTCTATGGATCACTGCCAAACATTGGGATCATCTCCTCTGTCCAGAGGTCTTCAACAGGAAGATGCCA
GCTGGCACCACTGCACTGTGATGGGGGCCCTCTCCTCTGCTGACTCTGCCGTTTCTCCAGGCCTCCGCTCAGTGATGAGACCAAGAGATC
GGAGACAAGCATGGTGCTGCTGCTTCTGCTGCTTCTCCAGAAAATCCCTGGGACACCTTTGTTCCAGCCTGGTTTCCTGGGCTGGGCTCA
GGAAAGCTGCCAAATTCAGTCCTATGTTGGGTCCAAGCTGCCCCTGTGCTGTTTCTGTCAAGCCAGGTGTGGACATTCCAAGTTCATATG
CGTGAACAAAAGAAAAGAGGAACCCAGTGGATGTAACAGAACCGACTCCAGTTGAATGTTTAGATTTTTGCTAAACTGTTTTCTTTTTCC
CTTTTTTGCTGTGGTTTGCATTCACGGCAGTAGTTAGCCCAGGTGTGGGGAACGAGAGTGCACTGCATGATAGCGTTCTGGTGAGCTGGG
AAGGACCCACCACTGCCACTGAGGATTGTTTTGGAAGAAAGGAATATTTTTATCTTGGGGACCAGCTAAGTCTCTGCAGTAGTGTGAAAT
TCCAAATGGTTGTTTTATCATTGGTTTGGTTTACCAAAAAAAAGGCAGGGAAAAAAAAAAAAAACAACCGTATGAGCGCATTGGCTTGTC
TGCCGCAGGCACAGAAGGGTAGAAAGCCACAGCAGGGGGCAGTCCAGCAGACTCTGACTCAACTTTCTAGGCACCTAGCAGAGAAAGATA
AGATCAAAAGGTGTTTGGTTTTTCTTTTAATTTTTATTGTAGTTTTTTTGGGTGGGTGGGGGAAGTAAACTAGACTGAAGCGATGGATTT
TTTTTTTCTTTTTTTTCTTTAGTGTTTTTCCCTTTGTTCTTGAACACTTTTGCCCTGCAGCCTCAGTTTTGAATTCTTTTAGCAACTTGG
ATTAGAGGGGCCCATATGTCAGAAGCTCCCAGCACCTCCTACTTGGGAGAAAAGTGAGCCATCTGCTGGTCAGGAAGTCCTCCAGAGAGG
CAGCTTTTCCCACAATGGTGGCAGGAAACTTTGGGGAAAGCAGGAATGGTGTCCACTGCTGCGGAGGAACTGCCTTCAGAGAAGGTGGGG
CTGGAAAAGGGTTAGAAGCCTCCTAGCTGGGATTGTCTTTGTTTCACCTTTCTTTAAATTAGAATTACAGAAGCCCCTGCCCAGTGAACA
GATAACGATTGGTCTTATGCTCCTCCCTTTCCCCCATTTTTTCTTTTGCTGTTTTGTTTTTTGTTTTTTGTTTGTTTGTTTGTTTTTTTG
AGACAGAGTCATGCTCTGTCACCCGGGCTGGAGTGCAGTGGTGCGATCTCAGCTCACTGTAACCTCCGCCTCCCGGGTTCAAGCAATTAT
TTGCCTCAGCCTCCCGAGTAGCTGGGATTATAGGCACCCGCCACCATGTCTGGCTTTTAGTAGAGACGGGGTTTCACCATCTTGGCCAGG
CTGGTCTTGGAACTCCTGACCTCGTGAGCCACCACGCCCAGCCTCTTTTGCTGTTTCATTGCTGACAGTGTTCAACAATATGCCCCATCT
TTATATATCCTAAGAAACACTAATCCTAGGTTATTGCTAGCCAAAATATTTTTGTCCTGAGTAGTGTCACTGGGCCAAAAGATAGATCAG
GACGACAGCCTTTAGTTTTCCTGAAATCACCAGGTCAGGCACAAGGAGAAAAGGTTCCTGGATACTGACTAACTTGGGTGGGTGGATCTA
GCCAGGAGAAAGACAGTAACATGTGTTCTGTACTTTCTGGGAAGATCCCTGAAGCCATCACAGAGGCTCCCCAACTTCTGAGTCGCCCAT
CTGTTGCTGTGGGAGTGTGAACGGATCGCTGAAGGAGAGGGAGCTTTGCTCTCTCTAGGTGGGCAAGTTTCCTGGGCTCTCTGTGTTGCC
TCCCTCTGGCTTCTTCCTCCCGTGCCCTCTCCCCGTGTGCCCCAGGGGGATCAGGGATCCTCACCCTCCTGAGGCCCAGTGGGGAAGAAT
GAACATGGCTTCATCCAGGTTAACTGATGCTGCCATTTGCCCAGCCTCTTCCATCCCAGCCCTGTCAGTGAGCCCAGGTCTGGTGCAACT
GCTGCAGGATGCCTGTAGTAGGGAACTCTGGAAGTGTATTGGGCTGAGGTGGGATTTTCCCTCCCCACAGTGCACTGAGCAATGGAGGGT
GGTGAGGGAGCCATGCTGCTGAATTCTGGTTGGCATTTCCCCATTATGTAAAATGGGGTGTTGGGTAGGGCAGACTCTGCTTGGGTTTGG
TTGTAAGATAAACCTGGAGGAGAAGCACAGTTGTCCCATTGAATTATTTGAGCAAAAACTACTGTAAATAACTTTTTTGTCTTTTGTCAA

>59000_59000_2_NFS1-TGIF2_NFS1_chr20_34268659_ENST00000374092_TGIF2_chr20_35219313_ENST00000373874_length(amino acids)=278AA_BP=
MQRLRKVGSASGTMLLRAAWRRAAVAVTAAPGPKPAAPTRGLRLRVGDRAPQSAVPADTAAAPEVGPVLRPLYMDVQATTPLDPRVLDAM
LPYLINYYGNPHSRTHAYGWESEAAMERARQQVASLIGADPREIIFTSGATESNNIAIKGVARFYRSRKKHLITTQTEHKCVLDSCRSLE
AEGFQVTYLPVQKSGIIDLKELEAAIQPDTSLVSVMTVNNEIGVKQPIAEIGRICSSRKVYFHTDAAQAVGKIPLDVNDMKIDLMSISGH

--------------------------------------------------------------
>59000_59000_3_NFS1-TGIF2_NFS1_chr20_34268659_ENST00000541387_TGIF2_chr20_35219313_ENST00000373872_length(transcript)=3742nt_BP=701nt
ACTTCCGGGAGCCTGGGGCCCAGGACTGCAGCGGCTTCGGAAGGTGGGCTCTGCCAGCGGGACCATGCTGCTCCGAGCCGCTTGGAGGCG
GGCGGCAGTGGCGGTGACAGCGGCTCCAGGGCCGAAGCCCGCGGCGCCCACTCGGGGGCTGCGCCTGCGCGTTGGAGACCGTGCTCCTCA
GTCTGCGGTTCCCGCAGATACAGCCGCTGCCCCGGAGGTGGGGCCAGTGCTGCGACCTCTCTATATGGATGTGCAAGCTACAACTCCTCT
GGACCCCCGGGTGCTTGATGCCATGCTCCCTTACCTAATCAACTACTATGGGAACCCACACTCCCGGACACATGCTTATGGCTGGGAGAG
TGAGGCAGCCATGGAACGTGCTCGTCAGCAAGTAGCATCTCTGATTGGAGCTGATCCTCGTGAGATCATTTTTACTAGTGGTGCTACTGA
ATCCAACAACATAGCAATTAAGGAACTAGAGGCTGCTATCCAGCCAGATACTAGCCTGGTGTCAGTCATGACTGTGAACAATGAGATTGG
AGTGAAGCAGCCTATTGCAGAAATAGGGCGGATTTGCAGTTCCAGAAAGGTATATTTCCATACTGATGCAGCCCAGGCTGTTGGAAAAAT
CCCACTTGATGTCAATGACATGAAAATTGATCTCATGAGCATTAGTGGTCACAAAATCTACGGTCCCAAAGATATGTAACTGGTTCATCA
ATGCCCGGCGGCGGCTTCTCCCAGACATGCTTCGGAAGGATGGCAAAGACCCTAATCAGTTTACCATTTCCCGCCGCGGGGGTAAGGCCT
CAGATGTGGCCCTCCCCCGTGGCAGCAGCCCCTCAGTGCTGGCTGTGTCTGTCCCAGCCCCCACCAATGTGCTCTCCCTGTCTGTGTGCT
CCATGCCGCTTCACTCAGGCCAGGGGGAAAAGCCAGCAGCCCCTTTCCCACGTGGGGAGCTGGAGTCTCCCAAGCCCCTGGTGACCCCTG
GTAGCACACTTACTCTGCTGACCAGGGCTGAGGCTGGAAGCCCCACAGGTGGACTCTTCAACACGCCACCACCCACACCCCCAGAGCAGG
ACAAAGAGGACTTCAGCAGCTTCCAGCTGCTGGTGGAGGTGGCGCTACAGAGGGCTGCTGAGATGGAGCTTCAGAAGCAGCAGGACCCAT
CACTCCCATTACTGCACACTCCCATCCCTTTAGTCTCTGAAAATCCCCAGTAGGCATCTGCCAAGAAGGGTGCTGAAGGCTCCAGCCAGC
TGTCCTGGGTTTCCGTTTTGGTTCCCTTTCATACAGAGGGTTTTCTATGGATCACTGCCAAACATTGGGATCATCTCCTCTGTCCAGAGG
TCTTCAACAGGAAGATGCCAGCTGGCACCACTGCACTGTGATGGGGGCCCTCTCCTCTGCTGACTCTGCCGTTTCTCCAGGCCTCCGCTC
AGTGATGAGACCAAGAGATCGGAGACAAGCATGGTGCTGCTGCTTCTGCTGCTTCTCCAGAAAATCCCTGGGACACCTTTGTTCCAGCCT
GGTTTCCTGGGCTGGGCTCAGGAAAGCTGCCAAATTCAGTCCTATGTTGGGTCCAAGCTGCCCCTGTGCTGTTTCTGTCAAGCCAGGTGT
GGACATTCCAAGTTCATATGCGTGAACAAAAGAAAAGAGGAACCCAGTGGATGTAACAGAACCGACTCCAGTTGAATGTTTAGATTTTTG
CTAAACTGTTTTCTTTTTCCCTTTTTTGCTGTGGTTTGCATTCACGGCAGTAGTTAGCCCAGGTGTGGGGAACGAGAGTGCACTGCATGA
TAGCGTTCTGGTGAGCTGGGAAGGACCCACCACTGCCACTGAGGATTGTTTTGGAAGAAAGGAATATTTTTATCTTGGGGACCAGCTAAG
TCTCTGCAGTAGTGTGAAATTCCAAATGGTTGTTTTATCATTGGTTTGGTTTACCAAAAAAAAGGCAGGGAAAAAAAAAAAAAACAACCG
TATGAGCGCATTGGCTTGTCTGCCGCAGGCACAGAAGGGTAGAAAGCCACAGCAGGGGGCAGTCCAGCAGACTCTGACTCAACTTTCTAG
GCACCTAGCAGAGAAAGATAAGATCAAAAGGTGTTTGGTTTTTCTTTTAATTTTTATTGTAGTTTTTTTGGGTGGGTGGGGGAAGTAAAC
TAGACTGAAGCGATGGATTTTTTTTTTCTTTTTTTTCTTTAGTGTTTTTCCCTTTGTTCTTGAACACTTTTGCCCTGCAGCCTCAGTTTT
GAATTCTTTTAGCAACTTGGATTAGAGGGGCCCATATGTCAGAAGCTCCCAGCACCTCCTACTTGGGAGAAAAGTGAGCCATCTGCTGGT
CAGGAAGTCCTCCAGAGAGGCAGCTTTTCCCACAATGGTGGCAGGAAACTTTGGGGAAAGCAGGAATGGTGTCCACTGCTGCGGAGGAAC
TGCCTTCAGAGAAGGTGGGGCTGGAAAAGGGTTAGAAGCCTCCTAGCTGGGATTGTCTTTGTTTCACCTTTCTTTAAATTAGAATTACAG
AAGCCCCTGCCCAGTGAACAGATAACGATTGGTCTTATGCTCCTCCCTTTCCCCCATTTTTTCTTTTGCTGTTTTGTTTTTTGTTTTTTG
TTTGTTTGTTTGTTTTTTTGAGACAGAGTCATGCTCTGTCACCCGGGCTGGAGTGCAGTGGTGCGATCTCAGCTCACTGTAACCTCCGCC
TCCCGGGTTCAAGCAATTATTTGCCTCAGCCTCCCGAGTAGCTGGGATTATAGGCACCCGCCACCATGTCTGGCTTTTAGTAGAGACGGG
GTTTCACCATCTTGGCCAGGCTGGTCTTGGAACTCCTGACCTCGTGAGCCACCACGCCCAGCCTCTTTTGCTGTTTCATTGCTGACAGTG
TTCAACAATATGCCCCATCTTTATATATCCTAAGAAACACTAATCCTAGGTTATTGCTAGCCAAAATATTTTTGTCCTGAGTAGTGTCAC
TGGGCCAAAAGATAGATCAGGACGACAGCCTTTAGTTTTCCTGAAATCACCAGGTCAGGCACAAGGAGAAAAGGTTCCTGGATACTGACT
AACTTGGGTGGGTGGATCTAGCCAGGAGAAAGACAGTAACATGTGTTCTGTACTTTCTGGGAAGATCCCTGAAGCCATCACAGAGGCTCC
CCAACTTCTGAGTCGCCCATCTGTTGCTGTGGGAGTGTGAACGGATCGCTGAAGGAGAGGGAGCTTTGCTCTCTCTAGGTGGGCAAGTTT
CCTGGGCTCTCTGTGTTGCCTCCCTCTGGCTTCTTCCTCCCGTGCCCTCTCCCCGTGTGCCCCAGGGGGATCAGGGATCCTCACCCTCCT
GAGGCCCAGTGGGGAAGAATGAACATGGCTTCATCCAGGTTAACTGATGCTGCCATTTGCCCAGCCTCTTCCATCCCAGCCCTGTCAGTG
AGCCCAGGTCTGGTGCAACTGCTGCAGGATGCCTGTAGTAGGGAACTCTGGAAGTGTATTGGGCTGAGGTGGGATTTTCCCTCCCCACAG
TGCACTGAGCAATGGAGGGTGGTGAGGGAGCCATGCTGCTGAATTCTGGTTGGCATTTCCCCATTATGTAAAATGGGGTGTTGGGTAGGG
CAGACTCTGCTTGGGTTTGGTTGTAAGATAAACCTGGAGGAGAAGCACAGTTGTCCCATTGAATTATTTGAGCAAAAACTACTGTAAATA

>59000_59000_3_NFS1-TGIF2_NFS1_chr20_34268659_ENST00000541387_TGIF2_chr20_35219313_ENST00000373872_length(amino acids)=227AA_BP=
MQRLRKVGSASGTMLLRAAWRRAAVAVTAAPGPKPAAPTRGLRLRVGDRAPQSAVPADTAAAPEVGPVLRPLYMDVQATTPLDPRVLDAM
LPYLINYYGNPHSRTHAYGWESEAAMERARQQVASLIGADPREIIFTSGATESNNIAIKELEAAIQPDTSLVSVMTVNNEIGVKQPIAEI

--------------------------------------------------------------
>59000_59000_4_NFS1-TGIF2_NFS1_chr20_34268659_ENST00000541387_TGIF2_chr20_35219313_ENST00000373874_length(transcript)=3742nt_BP=701nt
ACTTCCGGGAGCCTGGGGCCCAGGACTGCAGCGGCTTCGGAAGGTGGGCTCTGCCAGCGGGACCATGCTGCTCCGAGCCGCTTGGAGGCG
GGCGGCAGTGGCGGTGACAGCGGCTCCAGGGCCGAAGCCCGCGGCGCCCACTCGGGGGCTGCGCCTGCGCGTTGGAGACCGTGCTCCTCA
GTCTGCGGTTCCCGCAGATACAGCCGCTGCCCCGGAGGTGGGGCCAGTGCTGCGACCTCTCTATATGGATGTGCAAGCTACAACTCCTCT
GGACCCCCGGGTGCTTGATGCCATGCTCCCTTACCTAATCAACTACTATGGGAACCCACACTCCCGGACACATGCTTATGGCTGGGAGAG
TGAGGCAGCCATGGAACGTGCTCGTCAGCAAGTAGCATCTCTGATTGGAGCTGATCCTCGTGAGATCATTTTTACTAGTGGTGCTACTGA
ATCCAACAACATAGCAATTAAGGAACTAGAGGCTGCTATCCAGCCAGATACTAGCCTGGTGTCAGTCATGACTGTGAACAATGAGATTGG
AGTGAAGCAGCCTATTGCAGAAATAGGGCGGATTTGCAGTTCCAGAAAGGTATATTTCCATACTGATGCAGCCCAGGCTGTTGGAAAAAT
CCCACTTGATGTCAATGACATGAAAATTGATCTCATGAGCATTAGTGGTCACAAAATCTACGGTCCCAAAGATATGTAACTGGTTCATCA
ATGCCCGGCGGCGGCTTCTCCCAGACATGCTTCGGAAGGATGGCAAAGACCCTAATCAGTTTACCATTTCCCGCCGCGGGGGTAAGGCCT
CAGATGTGGCCCTCCCCCGTGGCAGCAGCCCCTCAGTGCTGGCTGTGTCTGTCCCAGCCCCCACCAATGTGCTCTCCCTGTCTGTGTGCT
CCATGCCGCTTCACTCAGGCCAGGGGGAAAAGCCAGCAGCCCCTTTCCCACGTGGGGAGCTGGAGTCTCCCAAGCCCCTGGTGACCCCTG
GTAGCACACTTACTCTGCTGACCAGGGCTGAGGCTGGAAGCCCCACAGGTGGACTCTTCAACACGCCACCACCCACACCCCCAGAGCAGG
ACAAAGAGGACTTCAGCAGCTTCCAGCTGCTGGTGGAGGTGGCGCTACAGAGGGCTGCTGAGATGGAGCTTCAGAAGCAGCAGGACCCAT
CACTCCCATTACTGCACACTCCCATCCCTTTAGTCTCTGAAAATCCCCAGTAGGCATCTGCCAAGAAGGGTGCTGAAGGCTCCAGCCAGC
TGTCCTGGGTTTCCGTTTTGGTTCCCTTTCATACAGAGGGTTTTCTATGGATCACTGCCAAACATTGGGATCATCTCCTCTGTCCAGAGG
TCTTCAACAGGAAGATGCCAGCTGGCACCACTGCACTGTGATGGGGGCCCTCTCCTCTGCTGACTCTGCCGTTTCTCCAGGCCTCCGCTC
AGTGATGAGACCAAGAGATCGGAGACAAGCATGGTGCTGCTGCTTCTGCTGCTTCTCCAGAAAATCCCTGGGACACCTTTGTTCCAGCCT
GGTTTCCTGGGCTGGGCTCAGGAAAGCTGCCAAATTCAGTCCTATGTTGGGTCCAAGCTGCCCCTGTGCTGTTTCTGTCAAGCCAGGTGT
GGACATTCCAAGTTCATATGCGTGAACAAAAGAAAAGAGGAACCCAGTGGATGTAACAGAACCGACTCCAGTTGAATGTTTAGATTTTTG
CTAAACTGTTTTCTTTTTCCCTTTTTTGCTGTGGTTTGCATTCACGGCAGTAGTTAGCCCAGGTGTGGGGAACGAGAGTGCACTGCATGA
TAGCGTTCTGGTGAGCTGGGAAGGACCCACCACTGCCACTGAGGATTGTTTTGGAAGAAAGGAATATTTTTATCTTGGGGACCAGCTAAG
TCTCTGCAGTAGTGTGAAATTCCAAATGGTTGTTTTATCATTGGTTTGGTTTACCAAAAAAAAGGCAGGGAAAAAAAAAAAAAACAACCG
TATGAGCGCATTGGCTTGTCTGCCGCAGGCACAGAAGGGTAGAAAGCCACAGCAGGGGGCAGTCCAGCAGACTCTGACTCAACTTTCTAG
GCACCTAGCAGAGAAAGATAAGATCAAAAGGTGTTTGGTTTTTCTTTTAATTTTTATTGTAGTTTTTTTGGGTGGGTGGGGGAAGTAAAC
TAGACTGAAGCGATGGATTTTTTTTTTCTTTTTTTTCTTTAGTGTTTTTCCCTTTGTTCTTGAACACTTTTGCCCTGCAGCCTCAGTTTT
GAATTCTTTTAGCAACTTGGATTAGAGGGGCCCATATGTCAGAAGCTCCCAGCACCTCCTACTTGGGAGAAAAGTGAGCCATCTGCTGGT
CAGGAAGTCCTCCAGAGAGGCAGCTTTTCCCACAATGGTGGCAGGAAACTTTGGGGAAAGCAGGAATGGTGTCCACTGCTGCGGAGGAAC
TGCCTTCAGAGAAGGTGGGGCTGGAAAAGGGTTAGAAGCCTCCTAGCTGGGATTGTCTTTGTTTCACCTTTCTTTAAATTAGAATTACAG
AAGCCCCTGCCCAGTGAACAGATAACGATTGGTCTTATGCTCCTCCCTTTCCCCCATTTTTTCTTTTGCTGTTTTGTTTTTTGTTTTTTG
TTTGTTTGTTTGTTTTTTTGAGACAGAGTCATGCTCTGTCACCCGGGCTGGAGTGCAGTGGTGCGATCTCAGCTCACTGTAACCTCCGCC
TCCCGGGTTCAAGCAATTATTTGCCTCAGCCTCCCGAGTAGCTGGGATTATAGGCACCCGCCACCATGTCTGGCTTTTAGTAGAGACGGG
GTTTCACCATCTTGGCCAGGCTGGTCTTGGAACTCCTGACCTCGTGAGCCACCACGCCCAGCCTCTTTTGCTGTTTCATTGCTGACAGTG
TTCAACAATATGCCCCATCTTTATATATCCTAAGAAACACTAATCCTAGGTTATTGCTAGCCAAAATATTTTTGTCCTGAGTAGTGTCAC
TGGGCCAAAAGATAGATCAGGACGACAGCCTTTAGTTTTCCTGAAATCACCAGGTCAGGCACAAGGAGAAAAGGTTCCTGGATACTGACT
AACTTGGGTGGGTGGATCTAGCCAGGAGAAAGACAGTAACATGTGTTCTGTACTTTCTGGGAAGATCCCTGAAGCCATCACAGAGGCTCC
CCAACTTCTGAGTCGCCCATCTGTTGCTGTGGGAGTGTGAACGGATCGCTGAAGGAGAGGGAGCTTTGCTCTCTCTAGGTGGGCAAGTTT
CCTGGGCTCTCTGTGTTGCCTCCCTCTGGCTTCTTCCTCCCGTGCCCTCTCCCCGTGTGCCCCAGGGGGATCAGGGATCCTCACCCTCCT
GAGGCCCAGTGGGGAAGAATGAACATGGCTTCATCCAGGTTAACTGATGCTGCCATTTGCCCAGCCTCTTCCATCCCAGCCCTGTCAGTG
AGCCCAGGTCTGGTGCAACTGCTGCAGGATGCCTGTAGTAGGGAACTCTGGAAGTGTATTGGGCTGAGGTGGGATTTTCCCTCCCCACAG
TGCACTGAGCAATGGAGGGTGGTGAGGGAGCCATGCTGCTGAATTCTGGTTGGCATTTCCCCATTATGTAAAATGGGGTGTTGGGTAGGG
CAGACTCTGCTTGGGTTTGGTTGTAAGATAAACCTGGAGGAGAAGCACAGTTGTCCCATTGAATTATTTGAGCAAAAACTACTGTAAATA

>59000_59000_4_NFS1-TGIF2_NFS1_chr20_34268659_ENST00000541387_TGIF2_chr20_35219313_ENST00000373874_length(amino acids)=227AA_BP=
MQRLRKVGSASGTMLLRAAWRRAAVAVTAAPGPKPAAPTRGLRLRVGDRAPQSAVPADTAAAPEVGPVLRPLYMDVQATTPLDPRVLDAM
LPYLINYYGNPHSRTHAYGWESEAAMERARQQVASLIGADPREIIFTSGATESNNIAIKELEAAIQPDTSLVSVMTVNNEIGVKQPIAEI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NFS1-TGIF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NFS1-TGIF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NFS1-TGIF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource