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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NFX1-ACO1 (FusionGDB2 ID:59003)

Fusion Gene Summary for NFX1-ACO1

check button Fusion gene summary
Fusion gene informationFusion gene name: NFX1-ACO1
Fusion gene ID: 59003
HgeneTgene
Gene symbol

NFX1

ACO1

Gene ID

4799

48

Gene namenuclear transcription factor, X-box binding 1aconitase 1
SynonymsNFX2|TEG-42|Tex42ACONS|HEL60|IREB1|IREBP|IREBP1|IRP1
Cytomap

9p13.3

9p21.1

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional repressor NF-X1nuclear transcription factor, X box-binding protein 1cytoplasmic aconitate hydrataseaconitase 1, solubleaconitate hydratase, cytoplasmiccitrate hydro-lyasecytoplasmic aconitasecytosplasmic aconitaseepididymis luminal protein 60epididymis secretory sperm binding proteinferritin repressor proteiniron
Modification date2020031320200313
UniProtAcc

Q12986

P21399

Ensembl transtripts involved in fusion geneENST00000379521, ENST00000379540, 
ENST00000318524, ENST00000463421, 
ENST00000309951, ENST00000379923, 
ENST00000541043, 
Fusion gene scores* DoF score16 X 12 X 11=21129 X 12 X 5=540
# samples 2212
** MAII scorelog2(22/2112*10)=-3.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NFX1 [Title/Abstract] AND ACO1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNFX1(33351788)-ACO1(32440463), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFX1

GO:0000122

negative regulation of transcription by RNA polymerase II

7964459

HgeneNFX1

GO:0051865

protein autoubiquitination

10500182

TgeneACO1

GO:0006101

citrate metabolic process

8041788|16527810

TgeneACO1

GO:0010040

response to iron(II) ion

8041788


check buttonFusion gene breakpoints across NFX1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ACO1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-18-4721-01ANFX1chr9

33351788

-ACO1chr9

32440463

+
ChimerDB4LUSCTCGA-18-4721-01ANFX1chr9

33351788

+ACO1chr9

32440463

+
ChimerDB4LUSCTCGA-18-4721NFX1chr9

33351788

+ACO1chr9

32440463

+


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Fusion Gene ORF analysis for NFX1-ACO1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000379521ENST00000309951NFX1chr9

33351788

+ACO1chr9

32440463

+
In-frameENST00000379521ENST00000379923NFX1chr9

33351788

+ACO1chr9

32440463

+
In-frameENST00000379521ENST00000541043NFX1chr9

33351788

+ACO1chr9

32440463

+
In-frameENST00000379540ENST00000309951NFX1chr9

33351788

+ACO1chr9

32440463

+
In-frameENST00000379540ENST00000379923NFX1chr9

33351788

+ACO1chr9

32440463

+
In-frameENST00000379540ENST00000541043NFX1chr9

33351788

+ACO1chr9

32440463

+
intron-3CDSENST00000318524ENST00000309951NFX1chr9

33351788

+ACO1chr9

32440463

+
intron-3CDSENST00000318524ENST00000379923NFX1chr9

33351788

+ACO1chr9

32440463

+
intron-3CDSENST00000318524ENST00000541043NFX1chr9

33351788

+ACO1chr9

32440463

+
intron-3CDSENST00000463421ENST00000309951NFX1chr9

33351788

+ACO1chr9

32440463

+
intron-3CDSENST00000463421ENST00000379923NFX1chr9

33351788

+ACO1chr9

32440463

+
intron-3CDSENST00000463421ENST00000541043NFX1chr9

33351788

+ACO1chr9

32440463

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379540NFX1chr933351788+ENST00000541043ACO1chr932440463+386127175031391029
ENST00000379540NFX1chr933351788+ENST00000379923ACO1chr932440463+386527175031391029
ENST00000379540NFX1chr933351788+ENST00000309951ACO1chr932440463+779827175031391029
ENST00000379521NFX1chr933351788+ENST00000541043ACO1chr932440463+386027164931381029
ENST00000379521NFX1chr933351788+ENST00000379923ACO1chr932440463+386427164931381029
ENST00000379521NFX1chr933351788+ENST00000309951ACO1chr932440463+779727164931381029

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379540ENST00000541043NFX1chr933351788+ACO1chr932440463+0.0003168360.99968314
ENST00000379540ENST00000379923NFX1chr933351788+ACO1chr932440463+0.0003151890.9996848
ENST00000379540ENST00000309951NFX1chr933351788+ACO1chr932440463+0.000158130.9998418
ENST00000379521ENST00000541043NFX1chr933351788+ACO1chr932440463+0.0003165450.9996835
ENST00000379521ENST00000379923NFX1chr933351788+ACO1chr932440463+0.0003148990.99968517
ENST00000379521ENST00000309951NFX1chr933351788+ACO1chr932440463+0.0001581230.9998418

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Fusion Genomic Features for NFX1-ACO1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NFX1chr933351788+ACO1chr932440462+6.94E-050.9999306
NFX1chr933351788+ACO1chr932440462+6.94E-050.9999306
NFX1chr933351788+ACO1chr932440462+6.94E-050.9999306
NFX1chr933351788+ACO1chr932440462+6.94E-050.9999306

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NFX1-ACO1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:33351788/chr9:32440463)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFX1

Q12986

ACO1

P21399

FUNCTION: Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:15371341, ECO:0000269|PubMed:17267499}.FUNCTION: Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. {ECO:0000269|PubMed:1946430, ECO:0000269|PubMed:23891004, ECO:0000269|PubMed:8041788}.; FUNCTION: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFX1chr9:33351788chr9:32440463ENST00000379521+1621358_4098851025.0Zinc fingerRING-type%3B atypical
HgeneNFX1chr9:33351788chr9:32440463ENST00000379521+1621453_4718851025.0Zinc fingerNote=NF-X1-type 1
HgeneNFX1chr9:33351788chr9:32440463ENST00000379521+1621506_5258851025.0Zinc fingerNote=NF-X1-type 2
HgeneNFX1chr9:33351788chr9:32440463ENST00000379521+1621567_5868851025.0Zinc fingerNote=NF-X1-type 3
HgeneNFX1chr9:33351788chr9:32440463ENST00000379521+1621632_6558851025.0Zinc fingerNote=NF-X1-type 4
HgeneNFX1chr9:33351788chr9:32440463ENST00000379521+1621694_7138851025.0Zinc fingerNote=NF-X1-type 5
HgeneNFX1chr9:33351788chr9:32440463ENST00000379521+1621721_7408851025.0Zinc fingerNote=NF-X1-type 6
HgeneNFX1chr9:33351788chr9:32440463ENST00000379521+1621832_8548851025.0Zinc fingerNote=NF-X1-type 7
HgeneNFX1chr9:33351788chr9:32440463ENST00000379521+1621863_8848851025.0Zinc fingerNote=NF-X1-type 8
HgeneNFX1chr9:33351788chr9:32440463ENST00000379540+1624358_4098851121.0Zinc fingerRING-type%3B atypical
HgeneNFX1chr9:33351788chr9:32440463ENST00000379540+1624453_4718851121.0Zinc fingerNote=NF-X1-type 1
HgeneNFX1chr9:33351788chr9:32440463ENST00000379540+1624506_5258851121.0Zinc fingerNote=NF-X1-type 2
HgeneNFX1chr9:33351788chr9:32440463ENST00000379540+1624567_5868851121.0Zinc fingerNote=NF-X1-type 3
HgeneNFX1chr9:33351788chr9:32440463ENST00000379540+1624632_6558851121.0Zinc fingerNote=NF-X1-type 4
HgeneNFX1chr9:33351788chr9:32440463ENST00000379540+1624694_7138851121.0Zinc fingerNote=NF-X1-type 5
HgeneNFX1chr9:33351788chr9:32440463ENST00000379540+1624721_7408851121.0Zinc fingerNote=NF-X1-type 6
HgeneNFX1chr9:33351788chr9:32440463ENST00000379540+1624832_8548851121.0Zinc fingerNote=NF-X1-type 7
HgeneNFX1chr9:33351788chr9:32440463ENST00000379540+1624863_8848851121.0Zinc fingerNote=NF-X1-type 8
TgeneACO1chr9:33351788chr9:32440463ENST000003099511721779_780749890.0RegionSubstrate binding
TgeneACO1chr9:33351788chr9:32440463ENST000003799231822779_780749890.0RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFX1chr9:33351788chr9:32440463ENST00000318524+1161084_10890834.0Compositional biasNote=Poly-Pro
HgeneNFX1chr9:33351788chr9:32440463ENST00000379521+16211084_10898851025.0Compositional biasNote=Poly-Pro
HgeneNFX1chr9:33351788chr9:32440463ENST00000379540+16241084_10898851121.0Compositional biasNote=Poly-Pro
HgeneNFX1chr9:33351788chr9:32440463ENST00000318524+116994_10620834.0DomainR3H
HgeneNFX1chr9:33351788chr9:32440463ENST00000379521+1621994_10628851025.0DomainR3H
HgeneNFX1chr9:33351788chr9:32440463ENST00000379540+1624994_10628851121.0DomainR3H
HgeneNFX1chr9:33351788chr9:32440463ENST00000318524+116358_4090834.0Zinc fingerRING-type%3B atypical
HgeneNFX1chr9:33351788chr9:32440463ENST00000318524+116453_4710834.0Zinc fingerNote=NF-X1-type 1
HgeneNFX1chr9:33351788chr9:32440463ENST00000318524+116506_5250834.0Zinc fingerNote=NF-X1-type 2
HgeneNFX1chr9:33351788chr9:32440463ENST00000318524+116567_5860834.0Zinc fingerNote=NF-X1-type 3
HgeneNFX1chr9:33351788chr9:32440463ENST00000318524+116632_6550834.0Zinc fingerNote=NF-X1-type 4
HgeneNFX1chr9:33351788chr9:32440463ENST00000318524+116694_7130834.0Zinc fingerNote=NF-X1-type 5
HgeneNFX1chr9:33351788chr9:32440463ENST00000318524+116721_7400834.0Zinc fingerNote=NF-X1-type 6
HgeneNFX1chr9:33351788chr9:32440463ENST00000318524+116832_8540834.0Zinc fingerNote=NF-X1-type 7
HgeneNFX1chr9:33351788chr9:32440463ENST00000318524+116863_8840834.0Zinc fingerNote=NF-X1-type 8
TgeneACO1chr9:33351788chr9:32440463ENST000003099511721205_207749890.0RegionSubstrate binding
TgeneACO1chr9:33351788chr9:32440463ENST000003799231822205_207749890.0RegionSubstrate binding


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Fusion Gene Sequence for NFX1-ACO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>59003_59003_1_NFX1-ACO1_NFX1_chr9_33351788_ENST00000379521_ACO1_chr9_32440463_ENST00000309951_length(transcript)=7797nt_BP=2716nt
ACGTGACCTGGTGACAGTGCTGACTTGGCTGTACAGCTCGATCTAGGTTCTGCGGCACGGGATGGCGGAGGCGCCTCCTGTCTCAGGTAC
TTTTAAATTCAATACAGATGCTGCTGAATTCATTCCTCAGGAGAAAAAAAATTCTGGTCTAAATTGTGGGACTCAAAGGAGACTAGACTC
TAATAGGATTGGTAGAAGAAATTACAGTTCACCACCTCCCTGTCACCTTTCCAGGCAGGTCCCTTATGATGAAATCTCTGCTGTTCATCA
GCATAGTTATCATCCGTCAGGAAGCAAACCTAAGAGTCAGCAGACGTCTTTCCAGTCCTCTCCTTGTAATAAATCGCCCAAGAGCCATGG
CCTTCAGAATCAACCTTGGCAGAAATTGAGGAATGAGAAGCACCATATCAGAGTCAAGAAAGCACAGAGTCTTGCTGAGCAGACCTCAGA
TACAGCTGGATTAGAGAGCTCGACCAGATCAGAGAGTGGGACAGACCTCAGAGAGCATAGTCCTTCTGAGAGTGAGAAGGAAGTTGTGGG
TGCAGATCCCAGGGGAGCAAAACCCAAAAAAGCAACACAGTTTGTATACAGCTATGGTAGAGGACCAAAAGTCAAGGGGAAACTCAAATG
TGAATGGAGTAACCGAACAACTCCAAAACCGGAGGATGCTGGACCCGAAAGTACCAAACCTGTGGGGGTTTTCCACCCTGACTCTTCAGA
GGCATCCTCTAGAAAAGGAGTATTGGATGGGTATGGAGCCAGACGAAATGAGCAGAGAAGATACCCACAGAAAAGGCCTCCCTGGGAAGT
GGAGGGGGCCAGGCCACGACCAGGCAGAAATCCACCAAAACAGGAGGGCCACCGACATACAAACGCAGGACACAGAAACAACATGGGCCC
CATTCCAAAGGATGACCTCAATGAAAGACCAGCAAAATCTACCTGTGACAGTGAGAACTTGGCAGTCATCAACAAGTCTTCCAGGAGGGT
TGACCAAGAGAAATGCACTGTACGGAGGCAGGATCCTCAAGTAGTATCTCCTTTCTCCCGAGGCAAACAGAACCATGTGCTAAAGAATGT
GGAAACGCACACAGGTTCTCTAATTGAACAACTAACAACAGAAAAATACGAGTGCATGGTGTGCTGTGAATTGGTTCGTGTCACGGCCCC
AGTGTGGAGTTGTCAGAGCTGTTACCATGTGTTTCATTTGAACTGCATAAAGAAATGGGCAAGGTCTCCAGCATCTCAAGCAGATGGCCA
GAGTGGTTGGAGGTGCCCTGCCTGTCAGAATGTTTCTGCACATGTTCCTAATACCTACACTTGTTTCTGTGGCAAGGTAAAGAATCCTGA
GTGGAGCAGAAATGAAATTCCACATAGCTGTGGTGAGGTTTGTAGAAAGAAACAGCCTGGCCAGGACTGCCCACATTCCTGTAACCTTCT
CTGCCATCCAGGACCCTGCCCACCCTGCCCTGCCTTTATGACAAAAACATGTGAATGTGGACGAACCAGGCACACAGTTCGCTGTGGTCA
GGCTGTCTCAGTCCACTGTTCTAACCCATGTGAGAATATTTTGAACTGTGGTCAGCACCAGTGTGCTGAGCTGTGCCATGGGGGTCAGTG
CCAGCCTTGCCAGATCATTTTGAACCAGGTATGCTATTGCGGCAGCACCTCCCGAGATGTGTTATGTGGAACCGATGTAGGAAAGTCTGA
TGGATTTGGGGATTTCAGCTGTTTAAAGATATGTGGCAAGGACTTGAAATGCGGTAACCATACATGTTCGCAAGTGTGCCACCCTCAGCC
CTGCCAGCAATGCCCACGGCTCCCCCAGCTGGTGCGCTGTTGCCCCTGTGGCCAAACTCCTCTCAGCCAATTGCTAGAACTTGGAAGTAG
TAGTCGGAAAACATGCATGGACCCTGTGCCTTCATGTGGAAAAGTGTGCGGCAAGCCTCTGCCTTGTGGTTCCTTAGATTTCATTCATAC
CTGTGAAAAGCTCTGCCATGAAGGAGACTGTGGACCATGCTCTCGCACATCAGTTATTTCCTGCAGATGCTCTTTCAGAACAAAGGAGCT
TCCATGTACCAGTCTCAAAAGTGAAGATGCTACATTTATGTGTGACAAGCGGTGTAACAAGAAACGGTTGTGTGGACGGCATAAATGTAA
TGAGATATGCTGTGTGGATAAGGAGCACAAGTGTCCTTTGATTTGTGGGAGGAAACTCCGTTGTGGCCTTCATAGGTGTGAAGAACCTTG
TCATCGTGGAAACTGCCAGACATGCTGGCAAGCCAGTTTTGATGAATTAACCTGCCATTGTGGTGCATCAGTGATTTACCCTCCAGTTCC
CTGTGGTACTAGGCCCCCTGAATGTACCCAAACCTGCGCTAGAGTCCATGAGTGTGACCATCCAGTATATCATTCTTGTCATAGTGAGGA
GAAGTGTCCCCCTTGCACTTTCCTAACTCAGAAGTGGTGCATGGGCAAGCATGAGTTTCGGAGCAACATCCCCTGTCACCTGGTTGATAT
CTCTTGCGGATTACCCTGCAGTGCCACGCTACCATGTGGGATGCACAAATGTCAGAGACTCTGTCACAAAGGGGAGTGTCTTGTGGATGA
GCCCTGCAAGCAGCCCTGCACCACCCCCAGAGCTGACTGTGGTCACCCGTGTATGGCACCCTGCCATACCAGCTCACCCTGCCCTGTGAC
TGCTTGTAAAGCTAAGCTTGATGTGTTTGATGCTGCTGAGCGGTACCAGCAGGCAGGCCTTCCCCTGATCGTTCTGGCTGGCAAAGAGTA
CGGTGCAGGCAGCTCCCGAGACTGGGCAGCTAAGGGCCCTTTCCTGCTGGGAATCAAAGCCGTCCTGGCCGAGAGCTACGAGCGCATTCA
CCGCAGTAACCTGGTTGGGATGGGTGTGATCCCACTTGAATATCTCCCTGGTGAGAATGCAGATGCCCTGGGGCTCACAGGGCAAGAACG
ATACACTATCATTATTCCAGAAAACCTCAAACCACAAATGAAAGTCCAGGTCAAGCTGGATACTGGCAAGACCTTCCAGGCTGTCATGAG
GTTTGACACTGATGTGGAGCTCACTTATTTCCTCAACGGGGGCATCCTCAACTACATGATCCGCAAGATGGCCAAGTAGGAGACGTGCAC
TTGGTGCTGCGCCCAGGGAGGAAGCCGCACCACCAGCCAGCGCAGGCCCTGGTGGAGAGGCCTCCCTGGCTGCCTCTGGGAGGGGTGCTG
CCTTGTAGATGGAGCAAGTGAGCACTGAGGGTCTGGTGCCAATCCTGTAGGCACAAAACCAGAAGTTTCTACATTCTCTATTTTTGTTAA
TCATCTTCTCTTTTTCCAGAATTTGGAAGCTAGAATGGTGGGAATGTCAGTAGTGCCAGAAAGAGAGAACCAAGCTTGTCTTTAAAGTTA
CTGATCACAGGACGTTGCTTTTTCACTGTTTCCTATTAATCTTCAGCTGAACACAAGCAAACCTTCTCAGGAGGTGTCTCCTACCCTCTT
ATTGTTCCTCTTACGCTCTGCTCAATGAAACCTTCCTCTTGAGGGTCATTTTCCTTTCTGTATTAATTATACCAGTGTTAAGTGACATAG
ATAAGAACTTTGCACACTTCAAATCAGAGCAGTGATTCTCTCTTCTCTCCCCTTTTCCTTCAGAGTGAATCATCCAGACTCCTCATGGAT
AGGTCGGGTGTTAAAGTTGTTTTGATTATGTACCTTTTGATAGATCCACATAAAAAGAAATGTGAAGTTTTCTTTTACTATCTTTTCATT
TATCAAGCAGAGACCTTTGTTGGGAGGCGGTTTGGGAGAACACATTTCTAATTTGAATGAAATGAAATCTATTTTCAGTGAAAACTTGTT
GACTTTGAGTTTTGCTGTGTTTGTGGCTAGAGTTTTGGGATATTTAGTACAGAGTGAATCTCACACCATATCATTGGGAAGCCTGAATAA
CCTTCATATTCTCCCATTTTTACAACTCTATCAGAACTGTACGGGTATAACGGAAATGTTTAGGAACCATTATGCTCGCTCTTCCCTGTT
TGGGAGCAGACAAGAAGGAAGAGTAGCCTGGTGGCAGTGGCAACGATATAAGTACATAAGGAAAAGCAGATAAACTTCAGGACACTAAAA
ACCAATTATCTGCTCATTTTTACCCCTGTAGTCATTTCTGGGCATGCCTTAGTTTGCTTGGGTTGCTATAATGTAATGCCATAGACTGGC
TGAAAGAACAGAAATGTATTTTCTCACAGTTATGGAGGCTGGAATTCTGAGATCAAAGTTGAAGCCACTTCATTTTCTGGTGAGGACACT
CTTCCTGGTTTACAGATGGCCACCTTCTTGCTTGTTCTCACATGGCATTTCTTTGGTATGTGCCTGGTGGGGGAGAGAGAAAATAGGCTC
TCATGTCTCTTCTTACAGCAACACTAATTGTATTGGATCAGGGTCCCACTCTTATGGAGACCCAGGAAAGCTGGTGGTATAACAACTTGG
TTCAAGTCCAAATGCCTAAGAACCTGGGGAGGGGCATGGGGAATGCTGGTATAAGTCCCAGAGTCTGAATGCCCAGGAACAAGCAGGAGC
TGTGATGTCCAAGGACAGGAGGGCAGGATCTTTGTAATGAATTTTTAATGTCAACCTTAGCACTCAGGGGATATGGCCTGGTCATCAGAA
CATCTGGAATCTAATCCTCTTTCTACTTCTCACCAGATGAGGGATCAAGACAGGTTATTTAGCATCCCTGCACTTGCGGTCCTGGGGATC
TTATTTATATTCATTTAAAAAATAAATTACAAACAAACAGCCAGGCGCAGTGGCTCATGCCTATAATTCCATCACTTTGGGAGGCCGAGG
TGGGTAGATCACCTGAGGTCAGGAGTTCTAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCAG
GTGTGGTATTGTGTGCCTGTAATCCCAGCTACACAGGAGGCTGAGGCAGGAGAATTGCTTAAACCCGGGATGCAGAGGCTGCAGTGAGCC
GAGATCGTGCCATTGCACGCCCGCCTGGGCTACAAGAGCAAAGCTCCGTCTCAAAAAAAAAAAAAAATTACAAACAAACAGAACTCCATT
GTACAAAAAAACCTGTGATCCTCAAGTTAAGATCAGTCCTAGAATAAAAACACTAAGAATGGCTGAGAAAACAGACCTCCACCCTCTCAG
CTCTCCATTACTGAGCAGCTGGGGAGCTGTCTCGCTCCCCGCATTCAGTGGCTCCTGTGGTCTGTATTTTTGTATCCTCCCCAAAATTCA
GGTGGTGAAACCTTAACCCCCCAGGTAATGGTAATAGAAGCTGGGGCCTTTGGAAGGTGATTAGATCATGAGGGTAGTGCCTTTTAAAAG
AGACTCAAGATAAGATAGAGACCCCCTCATTTCTTCTGCCATGGGAGAACACAGCAAGAAGTCACCATCCGTGAACCAGAAAGTGGGTTC
TCACCAGATACTGAATCTGCCAGTGCCTTGAACCTAGACTTTCCAGCCAGAACTGTGAGAAATTTCTATTGTTTATAAGCCACCCAGTTG
ATATTTAGTTACAGCAGCCCAACCAAGACTGTGGTTATGAGGAAACAAACACATTATTGTGGCTAGACTAATGGAATTGGGTCCCTTACC
TCCAAGTACACCCTCTGTCCTTTTCGGTAAAAATATCTTCGCCAGGCACGGTGTCTCATGCCTATGATCCCAACACTTTGGGAGGCCGAG
GCTGGAGGGTTGCTTGAGCCCAGAAGTTTGAGACCAGCCTGGGCAACACTCTACAAAAAAAAAAATAAATAAATAAATAAATAAAATAAA
TCAGCCAGGTGTGCACCTGTGGTCCCAGCTGTTCAGGAGGCTGAGGTGGGAGGATCACTTGAGCCTGGGAGGTCGTGGCTATGATTGCTC
CACTGCACTCCAGCCTGGGCAATAGAGTGAGACCCTATCAATCAATCACCACCCCCCCCCCCCCCAAAAAAAAAAGTATCTTGGCCAGTG
TCTCAACCTTGCCCACTAACAAGCCTAAATAAACCAACTTCTTTTACCTGGTTCTTTAAGGGCTGCTCGTCTTACTATCCAAATTAAAAA
TCTGCTGTTCTCCCTCCCATATTCTTTGCGAATGAAGATTCCCCTGTTTGTTTGGATAGTTTTCCAAATTCATTACTGCATTCCTGGCAT
CCGCAGCAAGCTAAGAGTTAGTTAATATTTTTAATATAGCAAATAAGGATGAGGGATGCCCTTCATGTGTATTTACACACCAGATTTTTA
TGGTACATAGGGAGTAATCTAGGGAAAAGATATATTAGGCATGAATCTTAGCTGTGGTAGAAGCACAGCTCAAATTAGCTTAAGGAAAAA
AAAAAAAAAGCTGGCTCATAGAACTTGAGGACAGTGGTGGCCATGACTATGGGCTTGATTGGATCTAGTGACTCAAGCTCCCTTCCATTT
GCCCCTCCAACCACCCCCCCATCCCTCCACCAATCATACCTTCTGTTGGCCTCTGCAGTAGAGTGGCCTCTTCTGGGCCCTTCCACATGC
CAGGGGATATGGCCACCAGCAGTTCTGGGGAAACCATTAGTAATTTGTGATCGTAGAGATTTGTCTCCCAGTATTCCCTAGGGCAAAAAT
ATTGGGAGTTCCTAGTCACCTAAATGAAGAACCTTATTTTTAGCAGTTTCCCTTTCAGGGCTCTAACAGGACTGTGGAGTAATGTACGGG
GTTATGTAGGAGCAATGCAGAGCCACTTTTGAAAAACAGTAGCCAAGGTTCTACTGGCTGCCTTCTTAGGACATTATTAAATATCATAAA
CACAAGTGGAATTTAACACCCAGCCAGTTTGTGTTCAACCAGACAGCGTCATTATGAACAAAGATTATATAACGATAGCTGATATTAAGT
AAGTTTTAAAAGTTGACATCCCAAGAGTGAAGCCTACTTATTCAGTACAGATTTGTTGAATGAAATTCGTAGTTTTATTTTACGGCATAA
TGAAACAGAGTTCCAGACATGTACCTGCCAAATTTGGTTCTGGTTGTCTTATCGTATGCAGGCTGGATACCTGCTACTGTGCTTCTACAG
GATGTTAACAGTGTCCCCTGAGTAAAACAGTTCCACGGTCAGTACATTTGGGAACCACTGAGTTAAATGGGTTTTATCACTGCAGAACAG
ACACAAGAACAATGTGTGCTGTAAATCACTGTTTGCAGGGAAGGTGGCAGCAAATGGCACAGAAACCCACCTGACCACAGACTGCTTTCT
TCTGGGCGTTCACGCACTGTGCTCCACAGGATACTCTTGAGAAACATTGAGCTATGGTTGGTCTGTTGTTTGAAATTCAAATAATAATGA
ATCCATTTTAAGGACAGGAATTGGTTTACTGACCTTGATGTTGGGATGACTCTTCATTTCAGGGTGAAAATATCACAGCATCAGCACAGG
CCAGGACCACAGAGATAACAAGGTGGTAGTTGTGTAACAGGTTGTGTCTGAACCACAGGAGCTTCAAAACATACACGGCTGGACACCCTG
CCAGGATGCTCTAATGGGGCTGGGCATGTGTCCATGAAAAAGACTCCCCAGTTGTTTCTAAAATGTGGCCTTTGTTCTAGAAATGCAATG
ACCAGCATTTGGGAGTCAGTCAAAAGATCCACTTCCTAAAAGCCTACCTGCTCATTTCTTTCATTCAATACATATTAACCAAGTGCCTAC

>59003_59003_1_NFX1-ACO1_NFX1_chr9_33351788_ENST00000379521_ACO1_chr9_32440463_ENST00000309951_length(amino acids)=1029AA_BP=889
MRHGMAEAPPVSGTFKFNTDAAEFIPQEKKNSGLNCGTQRRLDSNRIGRRNYSSPPPCHLSRQVPYDEISAVHQHSYHPSGSKPKSQQTS
FQSSPCNKSPKSHGLQNQPWQKLRNEKHHIRVKKAQSLAEQTSDTAGLESSTRSESGTDLREHSPSESEKEVVGADPRGAKPKKATQFVY
SYGRGPKVKGKLKCEWSNRTTPKPEDAGPESTKPVGVFHPDSSEASSRKGVLDGYGARRNEQRRYPQKRPPWEVEGARPRPGRNPPKQEG
HRHTNAGHRNNMGPIPKDDLNERPAKSTCDSENLAVINKSSRRVDQEKCTVRRQDPQVVSPFSRGKQNHVLKNVETHTGSLIEQLTTEKY
ECMVCCELVRVTAPVWSCQSCYHVFHLNCIKKWARSPASQADGQSGWRCPACQNVSAHVPNTYTCFCGKVKNPEWSRNEIPHSCGEVCRK
KQPGQDCPHSCNLLCHPGPCPPCPAFMTKTCECGRTRHTVRCGQAVSVHCSNPCENILNCGQHQCAELCHGGQCQPCQIILNQVCYCGST
SRDVLCGTDVGKSDGFGDFSCLKICGKDLKCGNHTCSQVCHPQPCQQCPRLPQLVRCCPCGQTPLSQLLELGSSSRKTCMDPVPSCGKVC
GKPLPCGSLDFIHTCEKLCHEGDCGPCSRTSVISCRCSFRTKELPCTSLKSEDATFMCDKRCNKKRLCGRHKCNEICCVDKEHKCPLICG
RKLRCGLHRCEEPCHRGNCQTCWQASFDELTCHCGASVIYPPVPCGTRPPECTQTCARVHECDHPVYHSCHSEEKCPPCTFLTQKWCMGK
HEFRSNIPCHLVDISCGLPCSATLPCGMHKCQRLCHKGECLVDEPCKQPCTTPRADCGHPCMAPCHTSSPCPVTACKAKLDVFDAAERYQ
QAGLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIPENLKPQMKVQ

--------------------------------------------------------------
>59003_59003_2_NFX1-ACO1_NFX1_chr9_33351788_ENST00000379521_ACO1_chr9_32440463_ENST00000379923_length(transcript)=3864nt_BP=2716nt
ACGTGACCTGGTGACAGTGCTGACTTGGCTGTACAGCTCGATCTAGGTTCTGCGGCACGGGATGGCGGAGGCGCCTCCTGTCTCAGGTAC
TTTTAAATTCAATACAGATGCTGCTGAATTCATTCCTCAGGAGAAAAAAAATTCTGGTCTAAATTGTGGGACTCAAAGGAGACTAGACTC
TAATAGGATTGGTAGAAGAAATTACAGTTCACCACCTCCCTGTCACCTTTCCAGGCAGGTCCCTTATGATGAAATCTCTGCTGTTCATCA
GCATAGTTATCATCCGTCAGGAAGCAAACCTAAGAGTCAGCAGACGTCTTTCCAGTCCTCTCCTTGTAATAAATCGCCCAAGAGCCATGG
CCTTCAGAATCAACCTTGGCAGAAATTGAGGAATGAGAAGCACCATATCAGAGTCAAGAAAGCACAGAGTCTTGCTGAGCAGACCTCAGA
TACAGCTGGATTAGAGAGCTCGACCAGATCAGAGAGTGGGACAGACCTCAGAGAGCATAGTCCTTCTGAGAGTGAGAAGGAAGTTGTGGG
TGCAGATCCCAGGGGAGCAAAACCCAAAAAAGCAACACAGTTTGTATACAGCTATGGTAGAGGACCAAAAGTCAAGGGGAAACTCAAATG
TGAATGGAGTAACCGAACAACTCCAAAACCGGAGGATGCTGGACCCGAAAGTACCAAACCTGTGGGGGTTTTCCACCCTGACTCTTCAGA
GGCATCCTCTAGAAAAGGAGTATTGGATGGGTATGGAGCCAGACGAAATGAGCAGAGAAGATACCCACAGAAAAGGCCTCCCTGGGAAGT
GGAGGGGGCCAGGCCACGACCAGGCAGAAATCCACCAAAACAGGAGGGCCACCGACATACAAACGCAGGACACAGAAACAACATGGGCCC
CATTCCAAAGGATGACCTCAATGAAAGACCAGCAAAATCTACCTGTGACAGTGAGAACTTGGCAGTCATCAACAAGTCTTCCAGGAGGGT
TGACCAAGAGAAATGCACTGTACGGAGGCAGGATCCTCAAGTAGTATCTCCTTTCTCCCGAGGCAAACAGAACCATGTGCTAAAGAATGT
GGAAACGCACACAGGTTCTCTAATTGAACAACTAACAACAGAAAAATACGAGTGCATGGTGTGCTGTGAATTGGTTCGTGTCACGGCCCC
AGTGTGGAGTTGTCAGAGCTGTTACCATGTGTTTCATTTGAACTGCATAAAGAAATGGGCAAGGTCTCCAGCATCTCAAGCAGATGGCCA
GAGTGGTTGGAGGTGCCCTGCCTGTCAGAATGTTTCTGCACATGTTCCTAATACCTACACTTGTTTCTGTGGCAAGGTAAAGAATCCTGA
GTGGAGCAGAAATGAAATTCCACATAGCTGTGGTGAGGTTTGTAGAAAGAAACAGCCTGGCCAGGACTGCCCACATTCCTGTAACCTTCT
CTGCCATCCAGGACCCTGCCCACCCTGCCCTGCCTTTATGACAAAAACATGTGAATGTGGACGAACCAGGCACACAGTTCGCTGTGGTCA
GGCTGTCTCAGTCCACTGTTCTAACCCATGTGAGAATATTTTGAACTGTGGTCAGCACCAGTGTGCTGAGCTGTGCCATGGGGGTCAGTG
CCAGCCTTGCCAGATCATTTTGAACCAGGTATGCTATTGCGGCAGCACCTCCCGAGATGTGTTATGTGGAACCGATGTAGGAAAGTCTGA
TGGATTTGGGGATTTCAGCTGTTTAAAGATATGTGGCAAGGACTTGAAATGCGGTAACCATACATGTTCGCAAGTGTGCCACCCTCAGCC
CTGCCAGCAATGCCCACGGCTCCCCCAGCTGGTGCGCTGTTGCCCCTGTGGCCAAACTCCTCTCAGCCAATTGCTAGAACTTGGAAGTAG
TAGTCGGAAAACATGCATGGACCCTGTGCCTTCATGTGGAAAAGTGTGCGGCAAGCCTCTGCCTTGTGGTTCCTTAGATTTCATTCATAC
CTGTGAAAAGCTCTGCCATGAAGGAGACTGTGGACCATGCTCTCGCACATCAGTTATTTCCTGCAGATGCTCTTTCAGAACAAAGGAGCT
TCCATGTACCAGTCTCAAAAGTGAAGATGCTACATTTATGTGTGACAAGCGGTGTAACAAGAAACGGTTGTGTGGACGGCATAAATGTAA
TGAGATATGCTGTGTGGATAAGGAGCACAAGTGTCCTTTGATTTGTGGGAGGAAACTCCGTTGTGGCCTTCATAGGTGTGAAGAACCTTG
TCATCGTGGAAACTGCCAGACATGCTGGCAAGCCAGTTTTGATGAATTAACCTGCCATTGTGGTGCATCAGTGATTTACCCTCCAGTTCC
CTGTGGTACTAGGCCCCCTGAATGTACCCAAACCTGCGCTAGAGTCCATGAGTGTGACCATCCAGTATATCATTCTTGTCATAGTGAGGA
GAAGTGTCCCCCTTGCACTTTCCTAACTCAGAAGTGGTGCATGGGCAAGCATGAGTTTCGGAGCAACATCCCCTGTCACCTGGTTGATAT
CTCTTGCGGATTACCCTGCAGTGCCACGCTACCATGTGGGATGCACAAATGTCAGAGACTCTGTCACAAAGGGGAGTGTCTTGTGGATGA
GCCCTGCAAGCAGCCCTGCACCACCCCCAGAGCTGACTGTGGTCACCCGTGTATGGCACCCTGCCATACCAGCTCACCCTGCCCTGTGAC
TGCTTGTAAAGCTAAGCTTGATGTGTTTGATGCTGCTGAGCGGTACCAGCAGGCAGGCCTTCCCCTGATCGTTCTGGCTGGCAAAGAGTA
CGGTGCAGGCAGCTCCCGAGACTGGGCAGCTAAGGGCCCTTTCCTGCTGGGAATCAAAGCCGTCCTGGCCGAGAGCTACGAGCGCATTCA
CCGCAGTAACCTGGTTGGGATGGGTGTGATCCCACTTGAATATCTCCCTGGTGAGAATGCAGATGCCCTGGGGCTCACAGGGCAAGAACG
ATACACTATCATTATTCCAGAAAACCTCAAACCACAAATGAAAGTCCAGGTCAAGCTGGATACTGGCAAGACCTTCCAGGCTGTCATGAG
GTTTGACACTGATGTGGAGCTCACTTATTTCCTCAACGGGGGCATCCTCAACTACATGATCCGCAAGATGGCCAAGTAGGAGACGTGCAC
TTGGTGCTGCGCCCAGGGAGGAAGCCGCACCACCAGCCAGCGCAGGCCCTGGTGGAGAGGCCTCCCTGGCTGCCTCTGGGAGGGGTGCTG
CCTTGTAGATGGAGCAAGTGAGCACTGAGGGTCTGGTGCCAATCCTGTAGGCACAAAACCAGAAGTTTCTACATTCTCTATTTTTGTTAA
TCATCTTCTCTTTTTCCAGAATTTGGAAGCTAGAATGGTGGGAATGTCAGTAGTGCCAGAAAGAGAGAACCAAGCTTGTCTTTAAAGTTA
CTGATCACAGGACGTTGCTTTTTCACTGTTTCCTATTAATCTTCAGCTGAACACAAGCAAACCTTCTCAGGAGGTGTCTCCTACCCTCTT
ATTGTTCCTCTTACGCTCTGCTCAATGAAACCTTCCTCTTGAGGGTCATTTTCCTTTCTGTATTAATTATACCAGTGTTAAGTGACATAG
ATAAGAACTTTGCACACTTCAAATCAGAGCAGTGATTCTCTCTTCTCTCCCCTTTTCCTTCAGAGTGAATCATCCAGACTCCTCATGGAT
AGGTCGGGTGTTAAAGTTGTTTTGATTATGTACCTTTTGATAGATCCACATAAAAAGAAATGTGAAGTTTTCTTTTACTATCTTTTCATT

>59003_59003_2_NFX1-ACO1_NFX1_chr9_33351788_ENST00000379521_ACO1_chr9_32440463_ENST00000379923_length(amino acids)=1029AA_BP=889
MRHGMAEAPPVSGTFKFNTDAAEFIPQEKKNSGLNCGTQRRLDSNRIGRRNYSSPPPCHLSRQVPYDEISAVHQHSYHPSGSKPKSQQTS
FQSSPCNKSPKSHGLQNQPWQKLRNEKHHIRVKKAQSLAEQTSDTAGLESSTRSESGTDLREHSPSESEKEVVGADPRGAKPKKATQFVY
SYGRGPKVKGKLKCEWSNRTTPKPEDAGPESTKPVGVFHPDSSEASSRKGVLDGYGARRNEQRRYPQKRPPWEVEGARPRPGRNPPKQEG
HRHTNAGHRNNMGPIPKDDLNERPAKSTCDSENLAVINKSSRRVDQEKCTVRRQDPQVVSPFSRGKQNHVLKNVETHTGSLIEQLTTEKY
ECMVCCELVRVTAPVWSCQSCYHVFHLNCIKKWARSPASQADGQSGWRCPACQNVSAHVPNTYTCFCGKVKNPEWSRNEIPHSCGEVCRK
KQPGQDCPHSCNLLCHPGPCPPCPAFMTKTCECGRTRHTVRCGQAVSVHCSNPCENILNCGQHQCAELCHGGQCQPCQIILNQVCYCGST
SRDVLCGTDVGKSDGFGDFSCLKICGKDLKCGNHTCSQVCHPQPCQQCPRLPQLVRCCPCGQTPLSQLLELGSSSRKTCMDPVPSCGKVC
GKPLPCGSLDFIHTCEKLCHEGDCGPCSRTSVISCRCSFRTKELPCTSLKSEDATFMCDKRCNKKRLCGRHKCNEICCVDKEHKCPLICG
RKLRCGLHRCEEPCHRGNCQTCWQASFDELTCHCGASVIYPPVPCGTRPPECTQTCARVHECDHPVYHSCHSEEKCPPCTFLTQKWCMGK
HEFRSNIPCHLVDISCGLPCSATLPCGMHKCQRLCHKGECLVDEPCKQPCTTPRADCGHPCMAPCHTSSPCPVTACKAKLDVFDAAERYQ
QAGLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIPENLKPQMKVQ

--------------------------------------------------------------
>59003_59003_3_NFX1-ACO1_NFX1_chr9_33351788_ENST00000379521_ACO1_chr9_32440463_ENST00000541043_length(transcript)=3860nt_BP=2716nt
ACGTGACCTGGTGACAGTGCTGACTTGGCTGTACAGCTCGATCTAGGTTCTGCGGCACGGGATGGCGGAGGCGCCTCCTGTCTCAGGTAC
TTTTAAATTCAATACAGATGCTGCTGAATTCATTCCTCAGGAGAAAAAAAATTCTGGTCTAAATTGTGGGACTCAAAGGAGACTAGACTC
TAATAGGATTGGTAGAAGAAATTACAGTTCACCACCTCCCTGTCACCTTTCCAGGCAGGTCCCTTATGATGAAATCTCTGCTGTTCATCA
GCATAGTTATCATCCGTCAGGAAGCAAACCTAAGAGTCAGCAGACGTCTTTCCAGTCCTCTCCTTGTAATAAATCGCCCAAGAGCCATGG
CCTTCAGAATCAACCTTGGCAGAAATTGAGGAATGAGAAGCACCATATCAGAGTCAAGAAAGCACAGAGTCTTGCTGAGCAGACCTCAGA
TACAGCTGGATTAGAGAGCTCGACCAGATCAGAGAGTGGGACAGACCTCAGAGAGCATAGTCCTTCTGAGAGTGAGAAGGAAGTTGTGGG
TGCAGATCCCAGGGGAGCAAAACCCAAAAAAGCAACACAGTTTGTATACAGCTATGGTAGAGGACCAAAAGTCAAGGGGAAACTCAAATG
TGAATGGAGTAACCGAACAACTCCAAAACCGGAGGATGCTGGACCCGAAAGTACCAAACCTGTGGGGGTTTTCCACCCTGACTCTTCAGA
GGCATCCTCTAGAAAAGGAGTATTGGATGGGTATGGAGCCAGACGAAATGAGCAGAGAAGATACCCACAGAAAAGGCCTCCCTGGGAAGT
GGAGGGGGCCAGGCCACGACCAGGCAGAAATCCACCAAAACAGGAGGGCCACCGACATACAAACGCAGGACACAGAAACAACATGGGCCC
CATTCCAAAGGATGACCTCAATGAAAGACCAGCAAAATCTACCTGTGACAGTGAGAACTTGGCAGTCATCAACAAGTCTTCCAGGAGGGT
TGACCAAGAGAAATGCACTGTACGGAGGCAGGATCCTCAAGTAGTATCTCCTTTCTCCCGAGGCAAACAGAACCATGTGCTAAAGAATGT
GGAAACGCACACAGGTTCTCTAATTGAACAACTAACAACAGAAAAATACGAGTGCATGGTGTGCTGTGAATTGGTTCGTGTCACGGCCCC
AGTGTGGAGTTGTCAGAGCTGTTACCATGTGTTTCATTTGAACTGCATAAAGAAATGGGCAAGGTCTCCAGCATCTCAAGCAGATGGCCA
GAGTGGTTGGAGGTGCCCTGCCTGTCAGAATGTTTCTGCACATGTTCCTAATACCTACACTTGTTTCTGTGGCAAGGTAAAGAATCCTGA
GTGGAGCAGAAATGAAATTCCACATAGCTGTGGTGAGGTTTGTAGAAAGAAACAGCCTGGCCAGGACTGCCCACATTCCTGTAACCTTCT
CTGCCATCCAGGACCCTGCCCACCCTGCCCTGCCTTTATGACAAAAACATGTGAATGTGGACGAACCAGGCACACAGTTCGCTGTGGTCA
GGCTGTCTCAGTCCACTGTTCTAACCCATGTGAGAATATTTTGAACTGTGGTCAGCACCAGTGTGCTGAGCTGTGCCATGGGGGTCAGTG
CCAGCCTTGCCAGATCATTTTGAACCAGGTATGCTATTGCGGCAGCACCTCCCGAGATGTGTTATGTGGAACCGATGTAGGAAAGTCTGA
TGGATTTGGGGATTTCAGCTGTTTAAAGATATGTGGCAAGGACTTGAAATGCGGTAACCATACATGTTCGCAAGTGTGCCACCCTCAGCC
CTGCCAGCAATGCCCACGGCTCCCCCAGCTGGTGCGCTGTTGCCCCTGTGGCCAAACTCCTCTCAGCCAATTGCTAGAACTTGGAAGTAG
TAGTCGGAAAACATGCATGGACCCTGTGCCTTCATGTGGAAAAGTGTGCGGCAAGCCTCTGCCTTGTGGTTCCTTAGATTTCATTCATAC
CTGTGAAAAGCTCTGCCATGAAGGAGACTGTGGACCATGCTCTCGCACATCAGTTATTTCCTGCAGATGCTCTTTCAGAACAAAGGAGCT
TCCATGTACCAGTCTCAAAAGTGAAGATGCTACATTTATGTGTGACAAGCGGTGTAACAAGAAACGGTTGTGTGGACGGCATAAATGTAA
TGAGATATGCTGTGTGGATAAGGAGCACAAGTGTCCTTTGATTTGTGGGAGGAAACTCCGTTGTGGCCTTCATAGGTGTGAAGAACCTTG
TCATCGTGGAAACTGCCAGACATGCTGGCAAGCCAGTTTTGATGAATTAACCTGCCATTGTGGTGCATCAGTGATTTACCCTCCAGTTCC
CTGTGGTACTAGGCCCCCTGAATGTACCCAAACCTGCGCTAGAGTCCATGAGTGTGACCATCCAGTATATCATTCTTGTCATAGTGAGGA
GAAGTGTCCCCCTTGCACTTTCCTAACTCAGAAGTGGTGCATGGGCAAGCATGAGTTTCGGAGCAACATCCCCTGTCACCTGGTTGATAT
CTCTTGCGGATTACCCTGCAGTGCCACGCTACCATGTGGGATGCACAAATGTCAGAGACTCTGTCACAAAGGGGAGTGTCTTGTGGATGA
GCCCTGCAAGCAGCCCTGCACCACCCCCAGAGCTGACTGTGGTCACCCGTGTATGGCACCCTGCCATACCAGCTCACCCTGCCCTGTGAC
TGCTTGTAAAGCTAAGCTTGATGTGTTTGATGCTGCTGAGCGGTACCAGCAGGCAGGCCTTCCCCTGATCGTTCTGGCTGGCAAAGAGTA
CGGTGCAGGCAGCTCCCGAGACTGGGCAGCTAAGGGCCCTTTCCTGCTGGGAATCAAAGCCGTCCTGGCCGAGAGCTACGAGCGCATTCA
CCGCAGTAACCTGGTTGGGATGGGTGTGATCCCACTTGAATATCTCCCTGGTGAGAATGCAGATGCCCTGGGGCTCACAGGGCAAGAACG
ATACACTATCATTATTCCAGAAAACCTCAAACCACAAATGAAAGTCCAGGTCAAGCTGGATACTGGCAAGACCTTCCAGGCTGTCATGAG
GTTTGACACTGATGTGGAGCTCACTTATTTCCTCAACGGGGGCATCCTCAACTACATGATCCGCAAGATGGCCAAGTAGGAGACGTGCAC
TTGGTGCTGCGCCCAGGGAGGAAGCCGCACCACCAGCCAGCGCAGGCCCTGGTGGAGAGGCCTCCCTGGCTGCCTCTGGGAGGGGTGCTG
CCTTGTAGATGGAGCAAGTGAGCACTGAGGGTCTGGTGCCAATCCTGTAGGCACAAAACCAGAAGTTTCTACATTCTCTATTTTTGTTAA
TCATCTTCTCTTTTTCCAGAATTTGGAAGCTAGAATGGTGGGAATGTCAGTAGTGCCAGAAAGAGAGAACCAAGCTTGTCTTTAAAGTTA
CTGATCACAGGACGTTGCTTTTTCACTGTTTCCTATTAATCTTCAGCTGAACACAAGCAAACCTTCTCAGGAGGTGTCTCCTACCCTCTT
ATTGTTCCTCTTACGCTCTGCTCAATGAAACCTTCCTCTTGAGGGTCATTTTCCTTTCTGTATTAATTATACCAGTGTTAAGTGACATAG
ATAAGAACTTTGCACACTTCAAATCAGAGCAGTGATTCTCTCTTCTCTCCCCTTTTCCTTCAGAGTGAATCATCCAGACTCCTCATGGAT
AGGTCGGGTGTTAAAGTTGTTTTGATTATGTACCTTTTGATAGATCCACATAAAAAGAAATGTGAAGTTTTCTTTTACTATCTTTTCATT

>59003_59003_3_NFX1-ACO1_NFX1_chr9_33351788_ENST00000379521_ACO1_chr9_32440463_ENST00000541043_length(amino acids)=1029AA_BP=889
MRHGMAEAPPVSGTFKFNTDAAEFIPQEKKNSGLNCGTQRRLDSNRIGRRNYSSPPPCHLSRQVPYDEISAVHQHSYHPSGSKPKSQQTS
FQSSPCNKSPKSHGLQNQPWQKLRNEKHHIRVKKAQSLAEQTSDTAGLESSTRSESGTDLREHSPSESEKEVVGADPRGAKPKKATQFVY
SYGRGPKVKGKLKCEWSNRTTPKPEDAGPESTKPVGVFHPDSSEASSRKGVLDGYGARRNEQRRYPQKRPPWEVEGARPRPGRNPPKQEG
HRHTNAGHRNNMGPIPKDDLNERPAKSTCDSENLAVINKSSRRVDQEKCTVRRQDPQVVSPFSRGKQNHVLKNVETHTGSLIEQLTTEKY
ECMVCCELVRVTAPVWSCQSCYHVFHLNCIKKWARSPASQADGQSGWRCPACQNVSAHVPNTYTCFCGKVKNPEWSRNEIPHSCGEVCRK
KQPGQDCPHSCNLLCHPGPCPPCPAFMTKTCECGRTRHTVRCGQAVSVHCSNPCENILNCGQHQCAELCHGGQCQPCQIILNQVCYCGST
SRDVLCGTDVGKSDGFGDFSCLKICGKDLKCGNHTCSQVCHPQPCQQCPRLPQLVRCCPCGQTPLSQLLELGSSSRKTCMDPVPSCGKVC
GKPLPCGSLDFIHTCEKLCHEGDCGPCSRTSVISCRCSFRTKELPCTSLKSEDATFMCDKRCNKKRLCGRHKCNEICCVDKEHKCPLICG
RKLRCGLHRCEEPCHRGNCQTCWQASFDELTCHCGASVIYPPVPCGTRPPECTQTCARVHECDHPVYHSCHSEEKCPPCTFLTQKWCMGK
HEFRSNIPCHLVDISCGLPCSATLPCGMHKCQRLCHKGECLVDEPCKQPCTTPRADCGHPCMAPCHTSSPCPVTACKAKLDVFDAAERYQ
QAGLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIPENLKPQMKVQ

--------------------------------------------------------------
>59003_59003_4_NFX1-ACO1_NFX1_chr9_33351788_ENST00000379540_ACO1_chr9_32440463_ENST00000309951_length(transcript)=7798nt_BP=2717nt
CACGTGACCTGGTGACAGTGCTGACTTGGCTGTACAGCTCGATCTAGGTTCTGCGGCACGGGATGGCGGAGGCGCCTCCTGTCTCAGGTA
CTTTTAAATTCAATACAGATGCTGCTGAATTCATTCCTCAGGAGAAAAAAAATTCTGGTCTAAATTGTGGGACTCAAAGGAGACTAGACT
CTAATAGGATTGGTAGAAGAAATTACAGTTCACCACCTCCCTGTCACCTTTCCAGGCAGGTCCCTTATGATGAAATCTCTGCTGTTCATC
AGCATAGTTATCATCCGTCAGGAAGCAAACCTAAGAGTCAGCAGACGTCTTTCCAGTCCTCTCCTTGTAATAAATCGCCCAAGAGCCATG
GCCTTCAGAATCAACCTTGGCAGAAATTGAGGAATGAGAAGCACCATATCAGAGTCAAGAAAGCACAGAGTCTTGCTGAGCAGACCTCAG
ATACAGCTGGATTAGAGAGCTCGACCAGATCAGAGAGTGGGACAGACCTCAGAGAGCATAGTCCTTCTGAGAGTGAGAAGGAAGTTGTGG
GTGCAGATCCCAGGGGAGCAAAACCCAAAAAAGCAACACAGTTTGTATACAGCTATGGTAGAGGACCAAAAGTCAAGGGGAAACTCAAAT
GTGAATGGAGTAACCGAACAACTCCAAAACCGGAGGATGCTGGACCCGAAAGTACCAAACCTGTGGGGGTTTTCCACCCTGACTCTTCAG
AGGCATCCTCTAGAAAAGGAGTATTGGATGGGTATGGAGCCAGACGAAATGAGCAGAGAAGATACCCACAGAAAAGGCCTCCCTGGGAAG
TGGAGGGGGCCAGGCCACGACCAGGCAGAAATCCACCAAAACAGGAGGGCCACCGACATACAAACGCAGGACACAGAAACAACATGGGCC
CCATTCCAAAGGATGACCTCAATGAAAGACCAGCAAAATCTACCTGTGACAGTGAGAACTTGGCAGTCATCAACAAGTCTTCCAGGAGGG
TTGACCAAGAGAAATGCACTGTACGGAGGCAGGATCCTCAAGTAGTATCTCCTTTCTCCCGAGGCAAACAGAACCATGTGCTAAAGAATG
TGGAAACGCACACAGGTTCTCTAATTGAACAACTAACAACAGAAAAATACGAGTGCATGGTGTGCTGTGAATTGGTTCGTGTCACGGCCC
CAGTGTGGAGTTGTCAGAGCTGTTACCATGTGTTTCATTTGAACTGCATAAAGAAATGGGCAAGGTCTCCAGCATCTCAAGCAGATGGCC
AGAGTGGTTGGAGGTGCCCTGCCTGTCAGAATGTTTCTGCACATGTTCCTAATACCTACACTTGTTTCTGTGGCAAGGTAAAGAATCCTG
AGTGGAGCAGAAATGAAATTCCACATAGCTGTGGTGAGGTTTGTAGAAAGAAACAGCCTGGCCAGGACTGCCCACATTCCTGTAACCTTC
TCTGCCATCCAGGACCCTGCCCACCCTGCCCTGCCTTTATGACAAAAACATGTGAATGTGGACGAACCAGGCACACAGTTCGCTGTGGTC
AGGCTGTCTCAGTCCACTGTTCTAACCCATGTGAGAATATTTTGAACTGTGGTCAGCACCAGTGTGCTGAGCTGTGCCATGGGGGTCAGT
GCCAGCCTTGCCAGATCATTTTGAACCAGGTATGCTATTGCGGCAGCACCTCCCGAGATGTGTTATGTGGAACCGATGTAGGAAAGTCTG
ATGGATTTGGGGATTTCAGCTGTTTAAAGATATGTGGCAAGGACTTGAAATGCGGTAACCATACATGTTCGCAAGTGTGCCACCCTCAGC
CCTGCCAGCAATGCCCACGGCTCCCCCAGCTGGTGCGCTGTTGCCCCTGTGGCCAAACTCCTCTCAGCCAATTGCTAGAACTTGGAAGTA
GTAGTCGGAAAACATGCATGGACCCTGTGCCTTCATGTGGAAAAGTGTGCGGCAAGCCTCTGCCTTGTGGTTCCTTAGATTTCATTCATA
CCTGTGAAAAGCTCTGCCATGAAGGAGACTGTGGACCATGCTCTCGCACATCAGTTATTTCCTGCAGATGCTCTTTCAGAACAAAGGAGC
TTCCATGTACCAGTCTCAAAAGTGAAGATGCTACATTTATGTGTGACAAGCGGTGTAACAAGAAACGGTTGTGTGGACGGCATAAATGTA
ATGAGATATGCTGTGTGGATAAGGAGCACAAGTGTCCTTTGATTTGTGGGAGGAAACTCCGTTGTGGCCTTCATAGGTGTGAAGAACCTT
GTCATCGTGGAAACTGCCAGACATGCTGGCAAGCCAGTTTTGATGAATTAACCTGCCATTGTGGTGCATCAGTGATTTACCCTCCAGTTC
CCTGTGGTACTAGGCCCCCTGAATGTACCCAAACCTGCGCTAGAGTCCATGAGTGTGACCATCCAGTATATCATTCTTGTCATAGTGAGG
AGAAGTGTCCCCCTTGCACTTTCCTAACTCAGAAGTGGTGCATGGGCAAGCATGAGTTTCGGAGCAACATCCCCTGTCACCTGGTTGATA
TCTCTTGCGGATTACCCTGCAGTGCCACGCTACCATGTGGGATGCACAAATGTCAGAGACTCTGTCACAAAGGGGAGTGTCTTGTGGATG
AGCCCTGCAAGCAGCCCTGCACCACCCCCAGAGCTGACTGTGGTCACCCGTGTATGGCACCCTGCCATACCAGCTCACCCTGCCCTGTGA
CTGCTTGTAAAGCTAAGCTTGATGTGTTTGATGCTGCTGAGCGGTACCAGCAGGCAGGCCTTCCCCTGATCGTTCTGGCTGGCAAAGAGT
ACGGTGCAGGCAGCTCCCGAGACTGGGCAGCTAAGGGCCCTTTCCTGCTGGGAATCAAAGCCGTCCTGGCCGAGAGCTACGAGCGCATTC
ACCGCAGTAACCTGGTTGGGATGGGTGTGATCCCACTTGAATATCTCCCTGGTGAGAATGCAGATGCCCTGGGGCTCACAGGGCAAGAAC
GATACACTATCATTATTCCAGAAAACCTCAAACCACAAATGAAAGTCCAGGTCAAGCTGGATACTGGCAAGACCTTCCAGGCTGTCATGA
GGTTTGACACTGATGTGGAGCTCACTTATTTCCTCAACGGGGGCATCCTCAACTACATGATCCGCAAGATGGCCAAGTAGGAGACGTGCA
CTTGGTGCTGCGCCCAGGGAGGAAGCCGCACCACCAGCCAGCGCAGGCCCTGGTGGAGAGGCCTCCCTGGCTGCCTCTGGGAGGGGTGCT
GCCTTGTAGATGGAGCAAGTGAGCACTGAGGGTCTGGTGCCAATCCTGTAGGCACAAAACCAGAAGTTTCTACATTCTCTATTTTTGTTA
ATCATCTTCTCTTTTTCCAGAATTTGGAAGCTAGAATGGTGGGAATGTCAGTAGTGCCAGAAAGAGAGAACCAAGCTTGTCTTTAAAGTT
ACTGATCACAGGACGTTGCTTTTTCACTGTTTCCTATTAATCTTCAGCTGAACACAAGCAAACCTTCTCAGGAGGTGTCTCCTACCCTCT
TATTGTTCCTCTTACGCTCTGCTCAATGAAACCTTCCTCTTGAGGGTCATTTTCCTTTCTGTATTAATTATACCAGTGTTAAGTGACATA
GATAAGAACTTTGCACACTTCAAATCAGAGCAGTGATTCTCTCTTCTCTCCCCTTTTCCTTCAGAGTGAATCATCCAGACTCCTCATGGA
TAGGTCGGGTGTTAAAGTTGTTTTGATTATGTACCTTTTGATAGATCCACATAAAAAGAAATGTGAAGTTTTCTTTTACTATCTTTTCAT
TTATCAAGCAGAGACCTTTGTTGGGAGGCGGTTTGGGAGAACACATTTCTAATTTGAATGAAATGAAATCTATTTTCAGTGAAAACTTGT
TGACTTTGAGTTTTGCTGTGTTTGTGGCTAGAGTTTTGGGATATTTAGTACAGAGTGAATCTCACACCATATCATTGGGAAGCCTGAATA
ACCTTCATATTCTCCCATTTTTACAACTCTATCAGAACTGTACGGGTATAACGGAAATGTTTAGGAACCATTATGCTCGCTCTTCCCTGT
TTGGGAGCAGACAAGAAGGAAGAGTAGCCTGGTGGCAGTGGCAACGATATAAGTACATAAGGAAAAGCAGATAAACTTCAGGACACTAAA
AACCAATTATCTGCTCATTTTTACCCCTGTAGTCATTTCTGGGCATGCCTTAGTTTGCTTGGGTTGCTATAATGTAATGCCATAGACTGG
CTGAAAGAACAGAAATGTATTTTCTCACAGTTATGGAGGCTGGAATTCTGAGATCAAAGTTGAAGCCACTTCATTTTCTGGTGAGGACAC
TCTTCCTGGTTTACAGATGGCCACCTTCTTGCTTGTTCTCACATGGCATTTCTTTGGTATGTGCCTGGTGGGGGAGAGAGAAAATAGGCT
CTCATGTCTCTTCTTACAGCAACACTAATTGTATTGGATCAGGGTCCCACTCTTATGGAGACCCAGGAAAGCTGGTGGTATAACAACTTG
GTTCAAGTCCAAATGCCTAAGAACCTGGGGAGGGGCATGGGGAATGCTGGTATAAGTCCCAGAGTCTGAATGCCCAGGAACAAGCAGGAG
CTGTGATGTCCAAGGACAGGAGGGCAGGATCTTTGTAATGAATTTTTAATGTCAACCTTAGCACTCAGGGGATATGGCCTGGTCATCAGA
ACATCTGGAATCTAATCCTCTTTCTACTTCTCACCAGATGAGGGATCAAGACAGGTTATTTAGCATCCCTGCACTTGCGGTCCTGGGGAT
CTTATTTATATTCATTTAAAAAATAAATTACAAACAAACAGCCAGGCGCAGTGGCTCATGCCTATAATTCCATCACTTTGGGAGGCCGAG
GTGGGTAGATCACCTGAGGTCAGGAGTTCTAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCA
GGTGTGGTATTGTGTGCCTGTAATCCCAGCTACACAGGAGGCTGAGGCAGGAGAATTGCTTAAACCCGGGATGCAGAGGCTGCAGTGAGC
CGAGATCGTGCCATTGCACGCCCGCCTGGGCTACAAGAGCAAAGCTCCGTCTCAAAAAAAAAAAAAAATTACAAACAAACAGAACTCCAT
TGTACAAAAAAACCTGTGATCCTCAAGTTAAGATCAGTCCTAGAATAAAAACACTAAGAATGGCTGAGAAAACAGACCTCCACCCTCTCA
GCTCTCCATTACTGAGCAGCTGGGGAGCTGTCTCGCTCCCCGCATTCAGTGGCTCCTGTGGTCTGTATTTTTGTATCCTCCCCAAAATTC
AGGTGGTGAAACCTTAACCCCCCAGGTAATGGTAATAGAAGCTGGGGCCTTTGGAAGGTGATTAGATCATGAGGGTAGTGCCTTTTAAAA
GAGACTCAAGATAAGATAGAGACCCCCTCATTTCTTCTGCCATGGGAGAACACAGCAAGAAGTCACCATCCGTGAACCAGAAAGTGGGTT
CTCACCAGATACTGAATCTGCCAGTGCCTTGAACCTAGACTTTCCAGCCAGAACTGTGAGAAATTTCTATTGTTTATAAGCCACCCAGTT
GATATTTAGTTACAGCAGCCCAACCAAGACTGTGGTTATGAGGAAACAAACACATTATTGTGGCTAGACTAATGGAATTGGGTCCCTTAC
CTCCAAGTACACCCTCTGTCCTTTTCGGTAAAAATATCTTCGCCAGGCACGGTGTCTCATGCCTATGATCCCAACACTTTGGGAGGCCGA
GGCTGGAGGGTTGCTTGAGCCCAGAAGTTTGAGACCAGCCTGGGCAACACTCTACAAAAAAAAAAATAAATAAATAAATAAATAAAATAA
ATCAGCCAGGTGTGCACCTGTGGTCCCAGCTGTTCAGGAGGCTGAGGTGGGAGGATCACTTGAGCCTGGGAGGTCGTGGCTATGATTGCT
CCACTGCACTCCAGCCTGGGCAATAGAGTGAGACCCTATCAATCAATCACCACCCCCCCCCCCCCCAAAAAAAAAAGTATCTTGGCCAGT
GTCTCAACCTTGCCCACTAACAAGCCTAAATAAACCAACTTCTTTTACCTGGTTCTTTAAGGGCTGCTCGTCTTACTATCCAAATTAAAA
ATCTGCTGTTCTCCCTCCCATATTCTTTGCGAATGAAGATTCCCCTGTTTGTTTGGATAGTTTTCCAAATTCATTACTGCATTCCTGGCA
TCCGCAGCAAGCTAAGAGTTAGTTAATATTTTTAATATAGCAAATAAGGATGAGGGATGCCCTTCATGTGTATTTACACACCAGATTTTT
ATGGTACATAGGGAGTAATCTAGGGAAAAGATATATTAGGCATGAATCTTAGCTGTGGTAGAAGCACAGCTCAAATTAGCTTAAGGAAAA
AAAAAAAAAAGCTGGCTCATAGAACTTGAGGACAGTGGTGGCCATGACTATGGGCTTGATTGGATCTAGTGACTCAAGCTCCCTTCCATT
TGCCCCTCCAACCACCCCCCCATCCCTCCACCAATCATACCTTCTGTTGGCCTCTGCAGTAGAGTGGCCTCTTCTGGGCCCTTCCACATG
CCAGGGGATATGGCCACCAGCAGTTCTGGGGAAACCATTAGTAATTTGTGATCGTAGAGATTTGTCTCCCAGTATTCCCTAGGGCAAAAA
TATTGGGAGTTCCTAGTCACCTAAATGAAGAACCTTATTTTTAGCAGTTTCCCTTTCAGGGCTCTAACAGGACTGTGGAGTAATGTACGG
GGTTATGTAGGAGCAATGCAGAGCCACTTTTGAAAAACAGTAGCCAAGGTTCTACTGGCTGCCTTCTTAGGACATTATTAAATATCATAA
ACACAAGTGGAATTTAACACCCAGCCAGTTTGTGTTCAACCAGACAGCGTCATTATGAACAAAGATTATATAACGATAGCTGATATTAAG
TAAGTTTTAAAAGTTGACATCCCAAGAGTGAAGCCTACTTATTCAGTACAGATTTGTTGAATGAAATTCGTAGTTTTATTTTACGGCATA
ATGAAACAGAGTTCCAGACATGTACCTGCCAAATTTGGTTCTGGTTGTCTTATCGTATGCAGGCTGGATACCTGCTACTGTGCTTCTACA
GGATGTTAACAGTGTCCCCTGAGTAAAACAGTTCCACGGTCAGTACATTTGGGAACCACTGAGTTAAATGGGTTTTATCACTGCAGAACA
GACACAAGAACAATGTGTGCTGTAAATCACTGTTTGCAGGGAAGGTGGCAGCAAATGGCACAGAAACCCACCTGACCACAGACTGCTTTC
TTCTGGGCGTTCACGCACTGTGCTCCACAGGATACTCTTGAGAAACATTGAGCTATGGTTGGTCTGTTGTTTGAAATTCAAATAATAATG
AATCCATTTTAAGGACAGGAATTGGTTTACTGACCTTGATGTTGGGATGACTCTTCATTTCAGGGTGAAAATATCACAGCATCAGCACAG
GCCAGGACCACAGAGATAACAAGGTGGTAGTTGTGTAACAGGTTGTGTCTGAACCACAGGAGCTTCAAAACATACACGGCTGGACACCCT
GCCAGGATGCTCTAATGGGGCTGGGCATGTGTCCATGAAAAAGACTCCCCAGTTGTTTCTAAAATGTGGCCTTTGTTCTAGAAATGCAAT
GACCAGCATTTGGGAGTCAGTCAAAAGATCCACTTCCTAAAAGCCTACCTGCTCATTTCTTTCATTCAATACATATTAACCAAGTGCCTA

>59003_59003_4_NFX1-ACO1_NFX1_chr9_33351788_ENST00000379540_ACO1_chr9_32440463_ENST00000309951_length(amino acids)=1029AA_BP=889
MRHGMAEAPPVSGTFKFNTDAAEFIPQEKKNSGLNCGTQRRLDSNRIGRRNYSSPPPCHLSRQVPYDEISAVHQHSYHPSGSKPKSQQTS
FQSSPCNKSPKSHGLQNQPWQKLRNEKHHIRVKKAQSLAEQTSDTAGLESSTRSESGTDLREHSPSESEKEVVGADPRGAKPKKATQFVY
SYGRGPKVKGKLKCEWSNRTTPKPEDAGPESTKPVGVFHPDSSEASSRKGVLDGYGARRNEQRRYPQKRPPWEVEGARPRPGRNPPKQEG
HRHTNAGHRNNMGPIPKDDLNERPAKSTCDSENLAVINKSSRRVDQEKCTVRRQDPQVVSPFSRGKQNHVLKNVETHTGSLIEQLTTEKY
ECMVCCELVRVTAPVWSCQSCYHVFHLNCIKKWARSPASQADGQSGWRCPACQNVSAHVPNTYTCFCGKVKNPEWSRNEIPHSCGEVCRK
KQPGQDCPHSCNLLCHPGPCPPCPAFMTKTCECGRTRHTVRCGQAVSVHCSNPCENILNCGQHQCAELCHGGQCQPCQIILNQVCYCGST
SRDVLCGTDVGKSDGFGDFSCLKICGKDLKCGNHTCSQVCHPQPCQQCPRLPQLVRCCPCGQTPLSQLLELGSSSRKTCMDPVPSCGKVC
GKPLPCGSLDFIHTCEKLCHEGDCGPCSRTSVISCRCSFRTKELPCTSLKSEDATFMCDKRCNKKRLCGRHKCNEICCVDKEHKCPLICG
RKLRCGLHRCEEPCHRGNCQTCWQASFDELTCHCGASVIYPPVPCGTRPPECTQTCARVHECDHPVYHSCHSEEKCPPCTFLTQKWCMGK
HEFRSNIPCHLVDISCGLPCSATLPCGMHKCQRLCHKGECLVDEPCKQPCTTPRADCGHPCMAPCHTSSPCPVTACKAKLDVFDAAERYQ
QAGLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIPENLKPQMKVQ

--------------------------------------------------------------
>59003_59003_5_NFX1-ACO1_NFX1_chr9_33351788_ENST00000379540_ACO1_chr9_32440463_ENST00000379923_length(transcript)=3865nt_BP=2717nt
CACGTGACCTGGTGACAGTGCTGACTTGGCTGTACAGCTCGATCTAGGTTCTGCGGCACGGGATGGCGGAGGCGCCTCCTGTCTCAGGTA
CTTTTAAATTCAATACAGATGCTGCTGAATTCATTCCTCAGGAGAAAAAAAATTCTGGTCTAAATTGTGGGACTCAAAGGAGACTAGACT
CTAATAGGATTGGTAGAAGAAATTACAGTTCACCACCTCCCTGTCACCTTTCCAGGCAGGTCCCTTATGATGAAATCTCTGCTGTTCATC
AGCATAGTTATCATCCGTCAGGAAGCAAACCTAAGAGTCAGCAGACGTCTTTCCAGTCCTCTCCTTGTAATAAATCGCCCAAGAGCCATG
GCCTTCAGAATCAACCTTGGCAGAAATTGAGGAATGAGAAGCACCATATCAGAGTCAAGAAAGCACAGAGTCTTGCTGAGCAGACCTCAG
ATACAGCTGGATTAGAGAGCTCGACCAGATCAGAGAGTGGGACAGACCTCAGAGAGCATAGTCCTTCTGAGAGTGAGAAGGAAGTTGTGG
GTGCAGATCCCAGGGGAGCAAAACCCAAAAAAGCAACACAGTTTGTATACAGCTATGGTAGAGGACCAAAAGTCAAGGGGAAACTCAAAT
GTGAATGGAGTAACCGAACAACTCCAAAACCGGAGGATGCTGGACCCGAAAGTACCAAACCTGTGGGGGTTTTCCACCCTGACTCTTCAG
AGGCATCCTCTAGAAAAGGAGTATTGGATGGGTATGGAGCCAGACGAAATGAGCAGAGAAGATACCCACAGAAAAGGCCTCCCTGGGAAG
TGGAGGGGGCCAGGCCACGACCAGGCAGAAATCCACCAAAACAGGAGGGCCACCGACATACAAACGCAGGACACAGAAACAACATGGGCC
CCATTCCAAAGGATGACCTCAATGAAAGACCAGCAAAATCTACCTGTGACAGTGAGAACTTGGCAGTCATCAACAAGTCTTCCAGGAGGG
TTGACCAAGAGAAATGCACTGTACGGAGGCAGGATCCTCAAGTAGTATCTCCTTTCTCCCGAGGCAAACAGAACCATGTGCTAAAGAATG
TGGAAACGCACACAGGTTCTCTAATTGAACAACTAACAACAGAAAAATACGAGTGCATGGTGTGCTGTGAATTGGTTCGTGTCACGGCCC
CAGTGTGGAGTTGTCAGAGCTGTTACCATGTGTTTCATTTGAACTGCATAAAGAAATGGGCAAGGTCTCCAGCATCTCAAGCAGATGGCC
AGAGTGGTTGGAGGTGCCCTGCCTGTCAGAATGTTTCTGCACATGTTCCTAATACCTACACTTGTTTCTGTGGCAAGGTAAAGAATCCTG
AGTGGAGCAGAAATGAAATTCCACATAGCTGTGGTGAGGTTTGTAGAAAGAAACAGCCTGGCCAGGACTGCCCACATTCCTGTAACCTTC
TCTGCCATCCAGGACCCTGCCCACCCTGCCCTGCCTTTATGACAAAAACATGTGAATGTGGACGAACCAGGCACACAGTTCGCTGTGGTC
AGGCTGTCTCAGTCCACTGTTCTAACCCATGTGAGAATATTTTGAACTGTGGTCAGCACCAGTGTGCTGAGCTGTGCCATGGGGGTCAGT
GCCAGCCTTGCCAGATCATTTTGAACCAGGTATGCTATTGCGGCAGCACCTCCCGAGATGTGTTATGTGGAACCGATGTAGGAAAGTCTG
ATGGATTTGGGGATTTCAGCTGTTTAAAGATATGTGGCAAGGACTTGAAATGCGGTAACCATACATGTTCGCAAGTGTGCCACCCTCAGC
CCTGCCAGCAATGCCCACGGCTCCCCCAGCTGGTGCGCTGTTGCCCCTGTGGCCAAACTCCTCTCAGCCAATTGCTAGAACTTGGAAGTA
GTAGTCGGAAAACATGCATGGACCCTGTGCCTTCATGTGGAAAAGTGTGCGGCAAGCCTCTGCCTTGTGGTTCCTTAGATTTCATTCATA
CCTGTGAAAAGCTCTGCCATGAAGGAGACTGTGGACCATGCTCTCGCACATCAGTTATTTCCTGCAGATGCTCTTTCAGAACAAAGGAGC
TTCCATGTACCAGTCTCAAAAGTGAAGATGCTACATTTATGTGTGACAAGCGGTGTAACAAGAAACGGTTGTGTGGACGGCATAAATGTA
ATGAGATATGCTGTGTGGATAAGGAGCACAAGTGTCCTTTGATTTGTGGGAGGAAACTCCGTTGTGGCCTTCATAGGTGTGAAGAACCTT
GTCATCGTGGAAACTGCCAGACATGCTGGCAAGCCAGTTTTGATGAATTAACCTGCCATTGTGGTGCATCAGTGATTTACCCTCCAGTTC
CCTGTGGTACTAGGCCCCCTGAATGTACCCAAACCTGCGCTAGAGTCCATGAGTGTGACCATCCAGTATATCATTCTTGTCATAGTGAGG
AGAAGTGTCCCCCTTGCACTTTCCTAACTCAGAAGTGGTGCATGGGCAAGCATGAGTTTCGGAGCAACATCCCCTGTCACCTGGTTGATA
TCTCTTGCGGATTACCCTGCAGTGCCACGCTACCATGTGGGATGCACAAATGTCAGAGACTCTGTCACAAAGGGGAGTGTCTTGTGGATG
AGCCCTGCAAGCAGCCCTGCACCACCCCCAGAGCTGACTGTGGTCACCCGTGTATGGCACCCTGCCATACCAGCTCACCCTGCCCTGTGA
CTGCTTGTAAAGCTAAGCTTGATGTGTTTGATGCTGCTGAGCGGTACCAGCAGGCAGGCCTTCCCCTGATCGTTCTGGCTGGCAAAGAGT
ACGGTGCAGGCAGCTCCCGAGACTGGGCAGCTAAGGGCCCTTTCCTGCTGGGAATCAAAGCCGTCCTGGCCGAGAGCTACGAGCGCATTC
ACCGCAGTAACCTGGTTGGGATGGGTGTGATCCCACTTGAATATCTCCCTGGTGAGAATGCAGATGCCCTGGGGCTCACAGGGCAAGAAC
GATACACTATCATTATTCCAGAAAACCTCAAACCACAAATGAAAGTCCAGGTCAAGCTGGATACTGGCAAGACCTTCCAGGCTGTCATGA
GGTTTGACACTGATGTGGAGCTCACTTATTTCCTCAACGGGGGCATCCTCAACTACATGATCCGCAAGATGGCCAAGTAGGAGACGTGCA
CTTGGTGCTGCGCCCAGGGAGGAAGCCGCACCACCAGCCAGCGCAGGCCCTGGTGGAGAGGCCTCCCTGGCTGCCTCTGGGAGGGGTGCT
GCCTTGTAGATGGAGCAAGTGAGCACTGAGGGTCTGGTGCCAATCCTGTAGGCACAAAACCAGAAGTTTCTACATTCTCTATTTTTGTTA
ATCATCTTCTCTTTTTCCAGAATTTGGAAGCTAGAATGGTGGGAATGTCAGTAGTGCCAGAAAGAGAGAACCAAGCTTGTCTTTAAAGTT
ACTGATCACAGGACGTTGCTTTTTCACTGTTTCCTATTAATCTTCAGCTGAACACAAGCAAACCTTCTCAGGAGGTGTCTCCTACCCTCT
TATTGTTCCTCTTACGCTCTGCTCAATGAAACCTTCCTCTTGAGGGTCATTTTCCTTTCTGTATTAATTATACCAGTGTTAAGTGACATA
GATAAGAACTTTGCACACTTCAAATCAGAGCAGTGATTCTCTCTTCTCTCCCCTTTTCCTTCAGAGTGAATCATCCAGACTCCTCATGGA
TAGGTCGGGTGTTAAAGTTGTTTTGATTATGTACCTTTTGATAGATCCACATAAAAAGAAATGTGAAGTTTTCTTTTACTATCTTTTCAT

>59003_59003_5_NFX1-ACO1_NFX1_chr9_33351788_ENST00000379540_ACO1_chr9_32440463_ENST00000379923_length(amino acids)=1029AA_BP=889
MRHGMAEAPPVSGTFKFNTDAAEFIPQEKKNSGLNCGTQRRLDSNRIGRRNYSSPPPCHLSRQVPYDEISAVHQHSYHPSGSKPKSQQTS
FQSSPCNKSPKSHGLQNQPWQKLRNEKHHIRVKKAQSLAEQTSDTAGLESSTRSESGTDLREHSPSESEKEVVGADPRGAKPKKATQFVY
SYGRGPKVKGKLKCEWSNRTTPKPEDAGPESTKPVGVFHPDSSEASSRKGVLDGYGARRNEQRRYPQKRPPWEVEGARPRPGRNPPKQEG
HRHTNAGHRNNMGPIPKDDLNERPAKSTCDSENLAVINKSSRRVDQEKCTVRRQDPQVVSPFSRGKQNHVLKNVETHTGSLIEQLTTEKY
ECMVCCELVRVTAPVWSCQSCYHVFHLNCIKKWARSPASQADGQSGWRCPACQNVSAHVPNTYTCFCGKVKNPEWSRNEIPHSCGEVCRK
KQPGQDCPHSCNLLCHPGPCPPCPAFMTKTCECGRTRHTVRCGQAVSVHCSNPCENILNCGQHQCAELCHGGQCQPCQIILNQVCYCGST
SRDVLCGTDVGKSDGFGDFSCLKICGKDLKCGNHTCSQVCHPQPCQQCPRLPQLVRCCPCGQTPLSQLLELGSSSRKTCMDPVPSCGKVC
GKPLPCGSLDFIHTCEKLCHEGDCGPCSRTSVISCRCSFRTKELPCTSLKSEDATFMCDKRCNKKRLCGRHKCNEICCVDKEHKCPLICG
RKLRCGLHRCEEPCHRGNCQTCWQASFDELTCHCGASVIYPPVPCGTRPPECTQTCARVHECDHPVYHSCHSEEKCPPCTFLTQKWCMGK
HEFRSNIPCHLVDISCGLPCSATLPCGMHKCQRLCHKGECLVDEPCKQPCTTPRADCGHPCMAPCHTSSPCPVTACKAKLDVFDAAERYQ
QAGLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIPENLKPQMKVQ

--------------------------------------------------------------
>59003_59003_6_NFX1-ACO1_NFX1_chr9_33351788_ENST00000379540_ACO1_chr9_32440463_ENST00000541043_length(transcript)=3861nt_BP=2717nt
CACGTGACCTGGTGACAGTGCTGACTTGGCTGTACAGCTCGATCTAGGTTCTGCGGCACGGGATGGCGGAGGCGCCTCCTGTCTCAGGTA
CTTTTAAATTCAATACAGATGCTGCTGAATTCATTCCTCAGGAGAAAAAAAATTCTGGTCTAAATTGTGGGACTCAAAGGAGACTAGACT
CTAATAGGATTGGTAGAAGAAATTACAGTTCACCACCTCCCTGTCACCTTTCCAGGCAGGTCCCTTATGATGAAATCTCTGCTGTTCATC
AGCATAGTTATCATCCGTCAGGAAGCAAACCTAAGAGTCAGCAGACGTCTTTCCAGTCCTCTCCTTGTAATAAATCGCCCAAGAGCCATG
GCCTTCAGAATCAACCTTGGCAGAAATTGAGGAATGAGAAGCACCATATCAGAGTCAAGAAAGCACAGAGTCTTGCTGAGCAGACCTCAG
ATACAGCTGGATTAGAGAGCTCGACCAGATCAGAGAGTGGGACAGACCTCAGAGAGCATAGTCCTTCTGAGAGTGAGAAGGAAGTTGTGG
GTGCAGATCCCAGGGGAGCAAAACCCAAAAAAGCAACACAGTTTGTATACAGCTATGGTAGAGGACCAAAAGTCAAGGGGAAACTCAAAT
GTGAATGGAGTAACCGAACAACTCCAAAACCGGAGGATGCTGGACCCGAAAGTACCAAACCTGTGGGGGTTTTCCACCCTGACTCTTCAG
AGGCATCCTCTAGAAAAGGAGTATTGGATGGGTATGGAGCCAGACGAAATGAGCAGAGAAGATACCCACAGAAAAGGCCTCCCTGGGAAG
TGGAGGGGGCCAGGCCACGACCAGGCAGAAATCCACCAAAACAGGAGGGCCACCGACATACAAACGCAGGACACAGAAACAACATGGGCC
CCATTCCAAAGGATGACCTCAATGAAAGACCAGCAAAATCTACCTGTGACAGTGAGAACTTGGCAGTCATCAACAAGTCTTCCAGGAGGG
TTGACCAAGAGAAATGCACTGTACGGAGGCAGGATCCTCAAGTAGTATCTCCTTTCTCCCGAGGCAAACAGAACCATGTGCTAAAGAATG
TGGAAACGCACACAGGTTCTCTAATTGAACAACTAACAACAGAAAAATACGAGTGCATGGTGTGCTGTGAATTGGTTCGTGTCACGGCCC
CAGTGTGGAGTTGTCAGAGCTGTTACCATGTGTTTCATTTGAACTGCATAAAGAAATGGGCAAGGTCTCCAGCATCTCAAGCAGATGGCC
AGAGTGGTTGGAGGTGCCCTGCCTGTCAGAATGTTTCTGCACATGTTCCTAATACCTACACTTGTTTCTGTGGCAAGGTAAAGAATCCTG
AGTGGAGCAGAAATGAAATTCCACATAGCTGTGGTGAGGTTTGTAGAAAGAAACAGCCTGGCCAGGACTGCCCACATTCCTGTAACCTTC
TCTGCCATCCAGGACCCTGCCCACCCTGCCCTGCCTTTATGACAAAAACATGTGAATGTGGACGAACCAGGCACACAGTTCGCTGTGGTC
AGGCTGTCTCAGTCCACTGTTCTAACCCATGTGAGAATATTTTGAACTGTGGTCAGCACCAGTGTGCTGAGCTGTGCCATGGGGGTCAGT
GCCAGCCTTGCCAGATCATTTTGAACCAGGTATGCTATTGCGGCAGCACCTCCCGAGATGTGTTATGTGGAACCGATGTAGGAAAGTCTG
ATGGATTTGGGGATTTCAGCTGTTTAAAGATATGTGGCAAGGACTTGAAATGCGGTAACCATACATGTTCGCAAGTGTGCCACCCTCAGC
CCTGCCAGCAATGCCCACGGCTCCCCCAGCTGGTGCGCTGTTGCCCCTGTGGCCAAACTCCTCTCAGCCAATTGCTAGAACTTGGAAGTA
GTAGTCGGAAAACATGCATGGACCCTGTGCCTTCATGTGGAAAAGTGTGCGGCAAGCCTCTGCCTTGTGGTTCCTTAGATTTCATTCATA
CCTGTGAAAAGCTCTGCCATGAAGGAGACTGTGGACCATGCTCTCGCACATCAGTTATTTCCTGCAGATGCTCTTTCAGAACAAAGGAGC
TTCCATGTACCAGTCTCAAAAGTGAAGATGCTACATTTATGTGTGACAAGCGGTGTAACAAGAAACGGTTGTGTGGACGGCATAAATGTA
ATGAGATATGCTGTGTGGATAAGGAGCACAAGTGTCCTTTGATTTGTGGGAGGAAACTCCGTTGTGGCCTTCATAGGTGTGAAGAACCTT
GTCATCGTGGAAACTGCCAGACATGCTGGCAAGCCAGTTTTGATGAATTAACCTGCCATTGTGGTGCATCAGTGATTTACCCTCCAGTTC
CCTGTGGTACTAGGCCCCCTGAATGTACCCAAACCTGCGCTAGAGTCCATGAGTGTGACCATCCAGTATATCATTCTTGTCATAGTGAGG
AGAAGTGTCCCCCTTGCACTTTCCTAACTCAGAAGTGGTGCATGGGCAAGCATGAGTTTCGGAGCAACATCCCCTGTCACCTGGTTGATA
TCTCTTGCGGATTACCCTGCAGTGCCACGCTACCATGTGGGATGCACAAATGTCAGAGACTCTGTCACAAAGGGGAGTGTCTTGTGGATG
AGCCCTGCAAGCAGCCCTGCACCACCCCCAGAGCTGACTGTGGTCACCCGTGTATGGCACCCTGCCATACCAGCTCACCCTGCCCTGTGA
CTGCTTGTAAAGCTAAGCTTGATGTGTTTGATGCTGCTGAGCGGTACCAGCAGGCAGGCCTTCCCCTGATCGTTCTGGCTGGCAAAGAGT
ACGGTGCAGGCAGCTCCCGAGACTGGGCAGCTAAGGGCCCTTTCCTGCTGGGAATCAAAGCCGTCCTGGCCGAGAGCTACGAGCGCATTC
ACCGCAGTAACCTGGTTGGGATGGGTGTGATCCCACTTGAATATCTCCCTGGTGAGAATGCAGATGCCCTGGGGCTCACAGGGCAAGAAC
GATACACTATCATTATTCCAGAAAACCTCAAACCACAAATGAAAGTCCAGGTCAAGCTGGATACTGGCAAGACCTTCCAGGCTGTCATGA
GGTTTGACACTGATGTGGAGCTCACTTATTTCCTCAACGGGGGCATCCTCAACTACATGATCCGCAAGATGGCCAAGTAGGAGACGTGCA
CTTGGTGCTGCGCCCAGGGAGGAAGCCGCACCACCAGCCAGCGCAGGCCCTGGTGGAGAGGCCTCCCTGGCTGCCTCTGGGAGGGGTGCT
GCCTTGTAGATGGAGCAAGTGAGCACTGAGGGTCTGGTGCCAATCCTGTAGGCACAAAACCAGAAGTTTCTACATTCTCTATTTTTGTTA
ATCATCTTCTCTTTTTCCAGAATTTGGAAGCTAGAATGGTGGGAATGTCAGTAGTGCCAGAAAGAGAGAACCAAGCTTGTCTTTAAAGTT
ACTGATCACAGGACGTTGCTTTTTCACTGTTTCCTATTAATCTTCAGCTGAACACAAGCAAACCTTCTCAGGAGGTGTCTCCTACCCTCT
TATTGTTCCTCTTACGCTCTGCTCAATGAAACCTTCCTCTTGAGGGTCATTTTCCTTTCTGTATTAATTATACCAGTGTTAAGTGACATA
GATAAGAACTTTGCACACTTCAAATCAGAGCAGTGATTCTCTCTTCTCTCCCCTTTTCCTTCAGAGTGAATCATCCAGACTCCTCATGGA
TAGGTCGGGTGTTAAAGTTGTTTTGATTATGTACCTTTTGATAGATCCACATAAAAAGAAATGTGAAGTTTTCTTTTACTATCTTTTCAT

>59003_59003_6_NFX1-ACO1_NFX1_chr9_33351788_ENST00000379540_ACO1_chr9_32440463_ENST00000541043_length(amino acids)=1029AA_BP=889
MRHGMAEAPPVSGTFKFNTDAAEFIPQEKKNSGLNCGTQRRLDSNRIGRRNYSSPPPCHLSRQVPYDEISAVHQHSYHPSGSKPKSQQTS
FQSSPCNKSPKSHGLQNQPWQKLRNEKHHIRVKKAQSLAEQTSDTAGLESSTRSESGTDLREHSPSESEKEVVGADPRGAKPKKATQFVY
SYGRGPKVKGKLKCEWSNRTTPKPEDAGPESTKPVGVFHPDSSEASSRKGVLDGYGARRNEQRRYPQKRPPWEVEGARPRPGRNPPKQEG
HRHTNAGHRNNMGPIPKDDLNERPAKSTCDSENLAVINKSSRRVDQEKCTVRRQDPQVVSPFSRGKQNHVLKNVETHTGSLIEQLTTEKY
ECMVCCELVRVTAPVWSCQSCYHVFHLNCIKKWARSPASQADGQSGWRCPACQNVSAHVPNTYTCFCGKVKNPEWSRNEIPHSCGEVCRK
KQPGQDCPHSCNLLCHPGPCPPCPAFMTKTCECGRTRHTVRCGQAVSVHCSNPCENILNCGQHQCAELCHGGQCQPCQIILNQVCYCGST
SRDVLCGTDVGKSDGFGDFSCLKICGKDLKCGNHTCSQVCHPQPCQQCPRLPQLVRCCPCGQTPLSQLLELGSSSRKTCMDPVPSCGKVC
GKPLPCGSLDFIHTCEKLCHEGDCGPCSRTSVISCRCSFRTKELPCTSLKSEDATFMCDKRCNKKRLCGRHKCNEICCVDKEHKCPLICG
RKLRCGLHRCEEPCHRGNCQTCWQASFDELTCHCGASVIYPPVPCGTRPPECTQTCARVHECDHPVYHSCHSEEKCPPCTFLTQKWCMGK
HEFRSNIPCHLVDISCGLPCSATLPCGMHKCQRLCHKGECLVDEPCKQPCTTPRADCGHPCMAPCHTSSPCPVTACKAKLDVFDAAERYQ
QAGLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIPENLKPQMKVQ

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Fusion Gene PPI Analysis for NFX1-ACO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneNFX1chr9:33351788chr9:32440463ENST00000379521+16219_26885.01025.0PABPC1 and PABC4
HgeneNFX1chr9:33351788chr9:32440463ENST00000379540+16249_26885.01121.0PABPC1 and PABC4


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNFX1chr9:33351788chr9:32440463ENST00000318524+1169_260834.0PABPC1 and PABC4


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NFX1-ACO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NFX1-ACO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource