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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NFX1-SPINK4 (FusionGDB2 ID:59017)

Fusion Gene Summary for NFX1-SPINK4

check button Fusion gene summary
Fusion gene informationFusion gene name: NFX1-SPINK4
Fusion gene ID: 59017
HgeneTgene
Gene symbol

NFX1

SPINK4

Gene ID

4799

27290

Gene namenuclear transcription factor, X-box binding 1serine peptidase inhibitor Kazal type 4
SynonymsNFX2|TEG-42|Tex42HEL136|PEC-60|PEC60
Cytomap

9p13.3

9p13.3

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional repressor NF-X1nuclear transcription factor, X box-binding protein 1serine protease inhibitor Kazal-type 4epididymis luminal protein 136gastrointestinal peptidepeptide PEC-60 homolog
Modification date2020031320200313
UniProtAcc

Q12986

.
Ensembl transtripts involved in fusion geneENST00000318524, ENST00000379521, 
ENST00000379540, ENST00000463421, 
ENST00000379721, ENST00000379723, 
ENST00000379725, 
Fusion gene scores* DoF score16 X 12 X 11=21125 X 3 X 6=90
# samples 226
** MAII scorelog2(22/2112*10)=-3.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NFX1 [Title/Abstract] AND SPINK4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNFX1(33319125)-SPINK4(33218363), # samples:2
NFX1(33344186)-SPINK4(33245110), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFX1

GO:0000122

negative regulation of transcription by RNA polymerase II

7964459

HgeneNFX1

GO:0051865

protein autoubiquitination

10500182


check buttonFusion gene breakpoints across NFX1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SPINK4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A3QA-01ANFX1chr9

33319125

-SPINK4chr9

33218363

+
ChimerDB4BRCATCGA-E9-A3QA-01ANFX1chr9

33319125

+SPINK4chr9

33218363

+
ChimerDB4UCECTCGA-PG-A915-01ANFX1chr9

33344186

-SPINK4chr9

33245110

+
ChimerDB4UCECTCGA-PG-A915-01ANFX1chr9

33344186

+SPINK4chr9

33245110

+


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Fusion Gene ORF analysis for NFX1-SPINK4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000318524ENST00000379721NFX1chr9

33319125

+SPINK4chr9

33218363

+
5CDS-intronENST00000318524ENST00000379723NFX1chr9

33319125

+SPINK4chr9

33218363

+
5CDS-intronENST00000379521ENST00000379721NFX1chr9

33319125

+SPINK4chr9

33218363

+
5CDS-intronENST00000379521ENST00000379723NFX1chr9

33319125

+SPINK4chr9

33218363

+
5CDS-intronENST00000379540ENST00000379721NFX1chr9

33319125

+SPINK4chr9

33218363

+
5CDS-intronENST00000379540ENST00000379723NFX1chr9

33319125

+SPINK4chr9

33218363

+
In-frameENST00000318524ENST00000379721NFX1chr9

33344186

+SPINK4chr9

33245110

+
In-frameENST00000318524ENST00000379723NFX1chr9

33344186

+SPINK4chr9

33245110

+
In-frameENST00000318524ENST00000379725NFX1chr9

33319125

+SPINK4chr9

33218363

+
In-frameENST00000318524ENST00000379725NFX1chr9

33344186

+SPINK4chr9

33245110

+
In-frameENST00000379521ENST00000379721NFX1chr9

33344186

+SPINK4chr9

33245110

+
In-frameENST00000379521ENST00000379723NFX1chr9

33344186

+SPINK4chr9

33245110

+
In-frameENST00000379521ENST00000379725NFX1chr9

33319125

+SPINK4chr9

33218363

+
In-frameENST00000379521ENST00000379725NFX1chr9

33344186

+SPINK4chr9

33245110

+
In-frameENST00000379540ENST00000379721NFX1chr9

33344186

+SPINK4chr9

33245110

+
In-frameENST00000379540ENST00000379723NFX1chr9

33344186

+SPINK4chr9

33245110

+
In-frameENST00000379540ENST00000379725NFX1chr9

33319125

+SPINK4chr9

33218363

+
In-frameENST00000379540ENST00000379725NFX1chr9

33344186

+SPINK4chr9

33245110

+
intron-3CDSENST00000463421ENST00000379721NFX1chr9

33344186

+SPINK4chr9

33245110

+
intron-3CDSENST00000463421ENST00000379723NFX1chr9

33344186

+SPINK4chr9

33245110

+
intron-3CDSENST00000463421ENST00000379725NFX1chr9

33319125

+SPINK4chr9

33218363

+
intron-3CDSENST00000463421ENST00000379725NFX1chr9

33344186

+SPINK4chr9

33245110

+
intron-intronENST00000463421ENST00000379721NFX1chr9

33319125

+SPINK4chr9

33218363

+
intron-intronENST00000463421ENST00000379723NFX1chr9

33319125

+SPINK4chr9

33218363

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379540NFX1chr933319125+ENST00000379725SPINK4chr933218363+25011968502071673
ENST00000379521NFX1chr933319125+ENST00000379725SPINK4chr933218363+25001967492070673
ENST00000318524NFX1chr933319125+ENST00000379725SPINK4chr933218363+24671934162037673

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379540ENST00000379725NFX1chr933319125+SPINK4chr933218363+0.0074943230.9925056
ENST00000379521ENST00000379725NFX1chr933319125+SPINK4chr933218363+0.0074785770.99252135
ENST00000318524ENST00000379725NFX1chr933319125+SPINK4chr933218363+0.0083497450.99165034

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Fusion Genomic Features for NFX1-SPINK4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NFX1chr933319125+SPINK4chr933218362+0.0007856740.9992143
NFX1chr933344186+SPINK4chr933245109+1.53E-050.99998474
NFX1chr933319125+SPINK4chr933218362+0.0007856740.9992143
NFX1chr933344186+SPINK4chr933245109+1.53E-050.99998474

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NFX1-SPINK4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:33319125/chr9:33218363)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFX1

Q12986

.
FUNCTION: Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:15371341, ECO:0000269|PubMed:17267499}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFX1chr9:33319125chr9:33218363ENST00000318524+916358_409635834.0Zinc fingerRING-type%3B atypical
HgeneNFX1chr9:33319125chr9:33218363ENST00000318524+916453_471635834.0Zinc fingerNote=NF-X1-type 1
HgeneNFX1chr9:33319125chr9:33218363ENST00000318524+916506_525635834.0Zinc fingerNote=NF-X1-type 2
HgeneNFX1chr9:33319125chr9:33218363ENST00000318524+916567_586635834.0Zinc fingerNote=NF-X1-type 3
HgeneNFX1chr9:33319125chr9:33218363ENST00000379521+921358_4096351025.0Zinc fingerRING-type%3B atypical
HgeneNFX1chr9:33319125chr9:33218363ENST00000379521+921453_4716351025.0Zinc fingerNote=NF-X1-type 1
HgeneNFX1chr9:33319125chr9:33218363ENST00000379521+921506_5256351025.0Zinc fingerNote=NF-X1-type 2
HgeneNFX1chr9:33319125chr9:33218363ENST00000379521+921567_5866351025.0Zinc fingerNote=NF-X1-type 3
HgeneNFX1chr9:33319125chr9:33218363ENST00000379540+924358_4096351121.0Zinc fingerRING-type%3B atypical
HgeneNFX1chr9:33319125chr9:33218363ENST00000379540+924453_4716351121.0Zinc fingerNote=NF-X1-type 1
HgeneNFX1chr9:33319125chr9:33218363ENST00000379540+924506_5256351121.0Zinc fingerNote=NF-X1-type 2
HgeneNFX1chr9:33319125chr9:33218363ENST00000379540+924567_5866351121.0Zinc fingerNote=NF-X1-type 3
HgeneNFX1chr9:33344186chr9:33245110ENST00000318524+1416358_409781834.0Zinc fingerRING-type%3B atypical
HgeneNFX1chr9:33344186chr9:33245110ENST00000318524+1416453_471781834.0Zinc fingerNote=NF-X1-type 1
HgeneNFX1chr9:33344186chr9:33245110ENST00000318524+1416506_525781834.0Zinc fingerNote=NF-X1-type 2
HgeneNFX1chr9:33344186chr9:33245110ENST00000318524+1416567_586781834.0Zinc fingerNote=NF-X1-type 3
HgeneNFX1chr9:33344186chr9:33245110ENST00000318524+1416632_655781834.0Zinc fingerNote=NF-X1-type 4
HgeneNFX1chr9:33344186chr9:33245110ENST00000318524+1416694_713781834.0Zinc fingerNote=NF-X1-type 5
HgeneNFX1chr9:33344186chr9:33245110ENST00000318524+1416721_740781834.0Zinc fingerNote=NF-X1-type 6
HgeneNFX1chr9:33344186chr9:33245110ENST00000379521+1421358_4097811025.0Zinc fingerRING-type%3B atypical
HgeneNFX1chr9:33344186chr9:33245110ENST00000379521+1421453_4717811025.0Zinc fingerNote=NF-X1-type 1
HgeneNFX1chr9:33344186chr9:33245110ENST00000379521+1421506_5257811025.0Zinc fingerNote=NF-X1-type 2
HgeneNFX1chr9:33344186chr9:33245110ENST00000379521+1421567_5867811025.0Zinc fingerNote=NF-X1-type 3
HgeneNFX1chr9:33344186chr9:33245110ENST00000379521+1421632_6557811025.0Zinc fingerNote=NF-X1-type 4
HgeneNFX1chr9:33344186chr9:33245110ENST00000379521+1421694_7137811025.0Zinc fingerNote=NF-X1-type 5
HgeneNFX1chr9:33344186chr9:33245110ENST00000379521+1421721_7407811025.0Zinc fingerNote=NF-X1-type 6
HgeneNFX1chr9:33344186chr9:33245110ENST00000379540+1424358_4097811121.0Zinc fingerRING-type%3B atypical
HgeneNFX1chr9:33344186chr9:33245110ENST00000379540+1424453_4717811121.0Zinc fingerNote=NF-X1-type 1
HgeneNFX1chr9:33344186chr9:33245110ENST00000379540+1424506_5257811121.0Zinc fingerNote=NF-X1-type 2
HgeneNFX1chr9:33344186chr9:33245110ENST00000379540+1424567_5867811121.0Zinc fingerNote=NF-X1-type 3
HgeneNFX1chr9:33344186chr9:33245110ENST00000379540+1424632_6557811121.0Zinc fingerNote=NF-X1-type 4
HgeneNFX1chr9:33344186chr9:33245110ENST00000379540+1424694_7137811121.0Zinc fingerNote=NF-X1-type 5
HgeneNFX1chr9:33344186chr9:33245110ENST00000379540+1424721_7407811121.0Zinc fingerNote=NF-X1-type 6
TgeneSPINK4chr9:33319125chr9:33218363ENST000003797210431_86087.0DomainKazal-like
TgeneSPINK4chr9:33344186chr9:33245110ENST000003797210431_862087.0DomainKazal-like

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFX1chr9:33319125chr9:33218363ENST00000318524+9161084_1089635834.0Compositional biasNote=Poly-Pro
HgeneNFX1chr9:33319125chr9:33218363ENST00000379521+9211084_10896351025.0Compositional biasNote=Poly-Pro
HgeneNFX1chr9:33319125chr9:33218363ENST00000379540+9241084_10896351121.0Compositional biasNote=Poly-Pro
HgeneNFX1chr9:33344186chr9:33245110ENST00000318524+14161084_1089781834.0Compositional biasNote=Poly-Pro
HgeneNFX1chr9:33344186chr9:33245110ENST00000379521+14211084_10897811025.0Compositional biasNote=Poly-Pro
HgeneNFX1chr9:33344186chr9:33245110ENST00000379540+14241084_10897811121.0Compositional biasNote=Poly-Pro
HgeneNFX1chr9:33319125chr9:33218363ENST00000318524+916994_1062635834.0DomainR3H
HgeneNFX1chr9:33319125chr9:33218363ENST00000379521+921994_10626351025.0DomainR3H
HgeneNFX1chr9:33319125chr9:33218363ENST00000379540+924994_10626351121.0DomainR3H
HgeneNFX1chr9:33344186chr9:33245110ENST00000318524+1416994_1062781834.0DomainR3H
HgeneNFX1chr9:33344186chr9:33245110ENST00000379521+1421994_10627811025.0DomainR3H
HgeneNFX1chr9:33344186chr9:33245110ENST00000379540+1424994_10627811121.0DomainR3H
HgeneNFX1chr9:33319125chr9:33218363ENST00000318524+916632_655635834.0Zinc fingerNote=NF-X1-type 4
HgeneNFX1chr9:33319125chr9:33218363ENST00000318524+916694_713635834.0Zinc fingerNote=NF-X1-type 5
HgeneNFX1chr9:33319125chr9:33218363ENST00000318524+916721_740635834.0Zinc fingerNote=NF-X1-type 6
HgeneNFX1chr9:33319125chr9:33218363ENST00000318524+916832_854635834.0Zinc fingerNote=NF-X1-type 7
HgeneNFX1chr9:33319125chr9:33218363ENST00000318524+916863_884635834.0Zinc fingerNote=NF-X1-type 8
HgeneNFX1chr9:33319125chr9:33218363ENST00000379521+921632_6556351025.0Zinc fingerNote=NF-X1-type 4
HgeneNFX1chr9:33319125chr9:33218363ENST00000379521+921694_7136351025.0Zinc fingerNote=NF-X1-type 5
HgeneNFX1chr9:33319125chr9:33218363ENST00000379521+921721_7406351025.0Zinc fingerNote=NF-X1-type 6
HgeneNFX1chr9:33319125chr9:33218363ENST00000379521+921832_8546351025.0Zinc fingerNote=NF-X1-type 7
HgeneNFX1chr9:33319125chr9:33218363ENST00000379521+921863_8846351025.0Zinc fingerNote=NF-X1-type 8
HgeneNFX1chr9:33319125chr9:33218363ENST00000379540+924632_6556351121.0Zinc fingerNote=NF-X1-type 4
HgeneNFX1chr9:33319125chr9:33218363ENST00000379540+924694_7136351121.0Zinc fingerNote=NF-X1-type 5
HgeneNFX1chr9:33319125chr9:33218363ENST00000379540+924721_7406351121.0Zinc fingerNote=NF-X1-type 6
HgeneNFX1chr9:33319125chr9:33218363ENST00000379540+924832_8546351121.0Zinc fingerNote=NF-X1-type 7
HgeneNFX1chr9:33319125chr9:33218363ENST00000379540+924863_8846351121.0Zinc fingerNote=NF-X1-type 8
HgeneNFX1chr9:33344186chr9:33245110ENST00000318524+1416832_854781834.0Zinc fingerNote=NF-X1-type 7
HgeneNFX1chr9:33344186chr9:33245110ENST00000318524+1416863_884781834.0Zinc fingerNote=NF-X1-type 8
HgeneNFX1chr9:33344186chr9:33245110ENST00000379521+1421832_8547811025.0Zinc fingerNote=NF-X1-type 7
HgeneNFX1chr9:33344186chr9:33245110ENST00000379521+1421863_8847811025.0Zinc fingerNote=NF-X1-type 8
HgeneNFX1chr9:33344186chr9:33245110ENST00000379540+1424832_8547811121.0Zinc fingerNote=NF-X1-type 7
HgeneNFX1chr9:33344186chr9:33245110ENST00000379540+1424863_8847811121.0Zinc fingerNote=NF-X1-type 8


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Fusion Gene Sequence for NFX1-SPINK4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>59017_59017_1_NFX1-SPINK4_NFX1_chr9_33319125_ENST00000318524_SPINK4_chr9_33218363_ENST00000379725_length(transcript)=2467nt_BP=1934nt
CAGCTCGATCTAGGTTCTGCGGCACGGGATGGCGGAGGCGCCTCCTGTCTCAGGTACTTTTAAATTCAATACAGATGCTGCTGAATTCAT
TCCTCAGGAGAAAAAAAATTCTGGTCTAAATTGTGGGACTCAAAGGAGACTAGACTCTAATAGGATTGGTAGAAGAAATTACAGTTCACC
ACCTCCCTGTCACCTTTCCAGGCAGGTCCCTTATGATGAAATCTCTGCTGTTCATCAGCATAGTTATCATCCGTCAGGAAGCAAACCTAA
GAGTCAGCAGACGTCTTTCCAGTCCTCTCCTTGTAATAAATCGCCCAAGAGCCATGGCCTTCAGAATCAACCTTGGCAGAAATTGAGGAA
TGAGAAGCACCATATCAGAGTCAAGAAAGCACAGAGTCTTGCTGAGCAGACCTCAGATACAGCTGGATTAGAGAGCTCGACCAGATCAGA
GAGTGGGACAGACCTCAGAGAGCATAGTCCTTCTGAGAGTGAGAAGGAAGTTGTGGGTGCAGATCCCAGGGGAGCAAAACCCAAAAAAGC
AACACAGTTTGTATACAGCTATGGTAGAGGACCAAAAGTCAAGGGGAAACTCAAATGTGAATGGAGTAACCGAACAACTCCAAAACCGGA
GGATGCTGGACCCGAAAGTACCAAACCTGTGGGGGTTTTCCACCCTGACTCTTCAGAGGCATCCTCTAGAAAAGGAGTATTGGATGGGTA
TGGAGCCAGACGAAATGAGCAGAGAAGATACCCACAGAAAAGGCCTCCCTGGGAAGTGGAGGGGGCCAGGCCACGACCAGGCAGAAATCC
ACCAAAACAGGAGGGCCACCGACATACAAACGCAGGACACAGAAACAACATGGGCCCCATTCCAAAGGATGACCTCAATGAAAGACCAGC
AAAATCTACCTGTGACAGTGAGAACTTGGCAGTCATCAACAAGTCTTCCAGGAGGGTTGACCAAGAGAAATGCACTGTACGGAGGCAGGA
TCCTCAAGTAGTATCTCCTTTCTCCCGAGGCAAACAGAACCATGTGCTAAAGAATGTGGAAACGCACACAGGTTCTCTAATTGAACAACT
AACAACAGAAAAATACGAGTGCATGGTGTGCTGTGAATTGGTTCGTGTCACGGCCCCAGTGTGGAGTTGTCAGAGCTGTTACCATGTGTT
TCATTTGAACTGCATAAAGAAATGGGCAAGGTCTCCAGCATCTCAAGCAGATGGCCAGAGTGGTTGGAGGTGCCCTGCCTGTCAGAATGT
TTCTGCACATGTTCCTAATACCTACACTTGTTTCTGTGGCAAGGTAAAGAATCCTGAGTGGAGCAGAAATGAAATTCCACATAGCTGTGG
TGAGGTTTGTAGAAAGAAACAGCCTGGCCAGGACTGCCCACATTCCTGTAACCTTCTCTGCCATCCAGGACCCTGCCCACCCTGCCCTGC
CTTTATGACAAAAACATGTGAATGTGGACGAACCAGGCACACAGTTCGCTGTGGTCAGGCTGTCTCAGTCCACTGTTCTAACCCATGTGA
GAATATTTTGAACTGTGGTCAGCACCAGTGTGCTGAGCTGTGCCATGGGGGTCAGTGCCAGCCTTGCCAGATCATTTTGAACCAGGTATG
CTATTGCGGCAGCACCTCCCGAGATGTGTTATGTGGAACCGATGTAGGAAAGTCTGATGGATTTGGGGATTTCAGCTGTTTAAAGATATG
TGGCAAGGACTTGAAATGCGGTAACCATACATGTTCGCAAGTGTGCCACCCTCAGCCCTGCCAGCAATGCCCACGGCTCCCCCAGCTGGT
GCGCTGTTGCCCCTGTGGCCAAACTCCTCTCAGCCAATTGCTAGAACTTGGAAGTAGTAGTCGGAAAACATGCATGGACCCTGTGCCTTC
ATGTGGAAAAGTGTGCGGCAAGCCTCTGCCTTGTGGTTCCTTAGTTCTGCAAATGGGAGGTACTGGAAAGAACGTGAGGGCAGGAGGAGA
GATATGCCAGGGTATTTATTGCCCTAGCTCCCCCTCTGCCAGACCACAGGTAGAATAGCAAGAAGTCTACATCCTGATGATCCTGGGCAT
TGGGAGCTCACCTCACCTTCTCTGGACTCTGGAGGGCACACACATATGGTCCCTGCTGGGGGATGCTTCGCACACAGACCGTCTTCCAGA
GGCAGGGGCAGGGAAACTGCTGTCAGAAGTGCCAGTGGCAGCAGGAAAGCTCCCTTTCTCAAGAATGCCCATCTGTGAACACATGGTAGA
GTCTCCAACCTGTTCCCAGATGTCCAACCTGGTCTGCGGCACTGATGGGCTCACATATACGAATGAATGCCAGCTCTGCTTGGCCCGGAT
AAAAACCAAACAGGACATCCAGATCATGAAAGATGGCAAATGCTGATCCCACAGGAGCACCTCAAGCCATGAAGTGTCAGCTGGAGAACA

>59017_59017_1_NFX1-SPINK4_NFX1_chr9_33319125_ENST00000318524_SPINK4_chr9_33218363_ENST00000379725_length(amino acids)=673AA_BP=639
MRHGMAEAPPVSGTFKFNTDAAEFIPQEKKNSGLNCGTQRRLDSNRIGRRNYSSPPPCHLSRQVPYDEISAVHQHSYHPSGSKPKSQQTS
FQSSPCNKSPKSHGLQNQPWQKLRNEKHHIRVKKAQSLAEQTSDTAGLESSTRSESGTDLREHSPSESEKEVVGADPRGAKPKKATQFVY
SYGRGPKVKGKLKCEWSNRTTPKPEDAGPESTKPVGVFHPDSSEASSRKGVLDGYGARRNEQRRYPQKRPPWEVEGARPRPGRNPPKQEG
HRHTNAGHRNNMGPIPKDDLNERPAKSTCDSENLAVINKSSRRVDQEKCTVRRQDPQVVSPFSRGKQNHVLKNVETHTGSLIEQLTTEKY
ECMVCCELVRVTAPVWSCQSCYHVFHLNCIKKWARSPASQADGQSGWRCPACQNVSAHVPNTYTCFCGKVKNPEWSRNEIPHSCGEVCRK
KQPGQDCPHSCNLLCHPGPCPPCPAFMTKTCECGRTRHTVRCGQAVSVHCSNPCENILNCGQHQCAELCHGGQCQPCQIILNQVCYCGST
SRDVLCGTDVGKSDGFGDFSCLKICGKDLKCGNHTCSQVCHPQPCQQCPRLPQLVRCCPCGQTPLSQLLELGSSSRKTCMDPVPSCGKVC

--------------------------------------------------------------
>59017_59017_2_NFX1-SPINK4_NFX1_chr9_33319125_ENST00000379521_SPINK4_chr9_33218363_ENST00000379725_length(transcript)=2500nt_BP=1967nt
ACGTGACCTGGTGACAGTGCTGACTTGGCTGTACAGCTCGATCTAGGTTCTGCGGCACGGGATGGCGGAGGCGCCTCCTGTCTCAGGTAC
TTTTAAATTCAATACAGATGCTGCTGAATTCATTCCTCAGGAGAAAAAAAATTCTGGTCTAAATTGTGGGACTCAAAGGAGACTAGACTC
TAATAGGATTGGTAGAAGAAATTACAGTTCACCACCTCCCTGTCACCTTTCCAGGCAGGTCCCTTATGATGAAATCTCTGCTGTTCATCA
GCATAGTTATCATCCGTCAGGAAGCAAACCTAAGAGTCAGCAGACGTCTTTCCAGTCCTCTCCTTGTAATAAATCGCCCAAGAGCCATGG
CCTTCAGAATCAACCTTGGCAGAAATTGAGGAATGAGAAGCACCATATCAGAGTCAAGAAAGCACAGAGTCTTGCTGAGCAGACCTCAGA
TACAGCTGGATTAGAGAGCTCGACCAGATCAGAGAGTGGGACAGACCTCAGAGAGCATAGTCCTTCTGAGAGTGAGAAGGAAGTTGTGGG
TGCAGATCCCAGGGGAGCAAAACCCAAAAAAGCAACACAGTTTGTATACAGCTATGGTAGAGGACCAAAAGTCAAGGGGAAACTCAAATG
TGAATGGAGTAACCGAACAACTCCAAAACCGGAGGATGCTGGACCCGAAAGTACCAAACCTGTGGGGGTTTTCCACCCTGACTCTTCAGA
GGCATCCTCTAGAAAAGGAGTATTGGATGGGTATGGAGCCAGACGAAATGAGCAGAGAAGATACCCACAGAAAAGGCCTCCCTGGGAAGT
GGAGGGGGCCAGGCCACGACCAGGCAGAAATCCACCAAAACAGGAGGGCCACCGACATACAAACGCAGGACACAGAAACAACATGGGCCC
CATTCCAAAGGATGACCTCAATGAAAGACCAGCAAAATCTACCTGTGACAGTGAGAACTTGGCAGTCATCAACAAGTCTTCCAGGAGGGT
TGACCAAGAGAAATGCACTGTACGGAGGCAGGATCCTCAAGTAGTATCTCCTTTCTCCCGAGGCAAACAGAACCATGTGCTAAAGAATGT
GGAAACGCACACAGGTTCTCTAATTGAACAACTAACAACAGAAAAATACGAGTGCATGGTGTGCTGTGAATTGGTTCGTGTCACGGCCCC
AGTGTGGAGTTGTCAGAGCTGTTACCATGTGTTTCATTTGAACTGCATAAAGAAATGGGCAAGGTCTCCAGCATCTCAAGCAGATGGCCA
GAGTGGTTGGAGGTGCCCTGCCTGTCAGAATGTTTCTGCACATGTTCCTAATACCTACACTTGTTTCTGTGGCAAGGTAAAGAATCCTGA
GTGGAGCAGAAATGAAATTCCACATAGCTGTGGTGAGGTTTGTAGAAAGAAACAGCCTGGCCAGGACTGCCCACATTCCTGTAACCTTCT
CTGCCATCCAGGACCCTGCCCACCCTGCCCTGCCTTTATGACAAAAACATGTGAATGTGGACGAACCAGGCACACAGTTCGCTGTGGTCA
GGCTGTCTCAGTCCACTGTTCTAACCCATGTGAGAATATTTTGAACTGTGGTCAGCACCAGTGTGCTGAGCTGTGCCATGGGGGTCAGTG
CCAGCCTTGCCAGATCATTTTGAACCAGGTATGCTATTGCGGCAGCACCTCCCGAGATGTGTTATGTGGAACCGATGTAGGAAAGTCTGA
TGGATTTGGGGATTTCAGCTGTTTAAAGATATGTGGCAAGGACTTGAAATGCGGTAACCATACATGTTCGCAAGTGTGCCACCCTCAGCC
CTGCCAGCAATGCCCACGGCTCCCCCAGCTGGTGCGCTGTTGCCCCTGTGGCCAAACTCCTCTCAGCCAATTGCTAGAACTTGGAAGTAG
TAGTCGGAAAACATGCATGGACCCTGTGCCTTCATGTGGAAAAGTGTGCGGCAAGCCTCTGCCTTGTGGTTCCTTAGTTCTGCAAATGGG
AGGTACTGGAAAGAACGTGAGGGCAGGAGGAGAGATATGCCAGGGTATTTATTGCCCTAGCTCCCCCTCTGCCAGACCACAGGTAGAATA
GCAAGAAGTCTACATCCTGATGATCCTGGGCATTGGGAGCTCACCTCACCTTCTCTGGACTCTGGAGGGCACACACATATGGTCCCTGCT
GGGGGATGCTTCGCACACAGACCGTCTTCCAGAGGCAGGGGCAGGGAAACTGCTGTCAGAAGTGCCAGTGGCAGCAGGAAAGCTCCCTTT
CTCAAGAATGCCCATCTGTGAACACATGGTAGAGTCTCCAACCTGTTCCCAGATGTCCAACCTGGTCTGCGGCACTGATGGGCTCACATA
TACGAATGAATGCCAGCTCTGCTTGGCCCGGATAAAAACCAAACAGGACATCCAGATCATGAAAGATGGCAAATGCTGATCCCACAGGAG

>59017_59017_2_NFX1-SPINK4_NFX1_chr9_33319125_ENST00000379521_SPINK4_chr9_33218363_ENST00000379725_length(amino acids)=673AA_BP=639
MRHGMAEAPPVSGTFKFNTDAAEFIPQEKKNSGLNCGTQRRLDSNRIGRRNYSSPPPCHLSRQVPYDEISAVHQHSYHPSGSKPKSQQTS
FQSSPCNKSPKSHGLQNQPWQKLRNEKHHIRVKKAQSLAEQTSDTAGLESSTRSESGTDLREHSPSESEKEVVGADPRGAKPKKATQFVY
SYGRGPKVKGKLKCEWSNRTTPKPEDAGPESTKPVGVFHPDSSEASSRKGVLDGYGARRNEQRRYPQKRPPWEVEGARPRPGRNPPKQEG
HRHTNAGHRNNMGPIPKDDLNERPAKSTCDSENLAVINKSSRRVDQEKCTVRRQDPQVVSPFSRGKQNHVLKNVETHTGSLIEQLTTEKY
ECMVCCELVRVTAPVWSCQSCYHVFHLNCIKKWARSPASQADGQSGWRCPACQNVSAHVPNTYTCFCGKVKNPEWSRNEIPHSCGEVCRK
KQPGQDCPHSCNLLCHPGPCPPCPAFMTKTCECGRTRHTVRCGQAVSVHCSNPCENILNCGQHQCAELCHGGQCQPCQIILNQVCYCGST
SRDVLCGTDVGKSDGFGDFSCLKICGKDLKCGNHTCSQVCHPQPCQQCPRLPQLVRCCPCGQTPLSQLLELGSSSRKTCMDPVPSCGKVC

--------------------------------------------------------------
>59017_59017_3_NFX1-SPINK4_NFX1_chr9_33319125_ENST00000379540_SPINK4_chr9_33218363_ENST00000379725_length(transcript)=2501nt_BP=1968nt
CACGTGACCTGGTGACAGTGCTGACTTGGCTGTACAGCTCGATCTAGGTTCTGCGGCACGGGATGGCGGAGGCGCCTCCTGTCTCAGGTA
CTTTTAAATTCAATACAGATGCTGCTGAATTCATTCCTCAGGAGAAAAAAAATTCTGGTCTAAATTGTGGGACTCAAAGGAGACTAGACT
CTAATAGGATTGGTAGAAGAAATTACAGTTCACCACCTCCCTGTCACCTTTCCAGGCAGGTCCCTTATGATGAAATCTCTGCTGTTCATC
AGCATAGTTATCATCCGTCAGGAAGCAAACCTAAGAGTCAGCAGACGTCTTTCCAGTCCTCTCCTTGTAATAAATCGCCCAAGAGCCATG
GCCTTCAGAATCAACCTTGGCAGAAATTGAGGAATGAGAAGCACCATATCAGAGTCAAGAAAGCACAGAGTCTTGCTGAGCAGACCTCAG
ATACAGCTGGATTAGAGAGCTCGACCAGATCAGAGAGTGGGACAGACCTCAGAGAGCATAGTCCTTCTGAGAGTGAGAAGGAAGTTGTGG
GTGCAGATCCCAGGGGAGCAAAACCCAAAAAAGCAACACAGTTTGTATACAGCTATGGTAGAGGACCAAAAGTCAAGGGGAAACTCAAAT
GTGAATGGAGTAACCGAACAACTCCAAAACCGGAGGATGCTGGACCCGAAAGTACCAAACCTGTGGGGGTTTTCCACCCTGACTCTTCAG
AGGCATCCTCTAGAAAAGGAGTATTGGATGGGTATGGAGCCAGACGAAATGAGCAGAGAAGATACCCACAGAAAAGGCCTCCCTGGGAAG
TGGAGGGGGCCAGGCCACGACCAGGCAGAAATCCACCAAAACAGGAGGGCCACCGACATACAAACGCAGGACACAGAAACAACATGGGCC
CCATTCCAAAGGATGACCTCAATGAAAGACCAGCAAAATCTACCTGTGACAGTGAGAACTTGGCAGTCATCAACAAGTCTTCCAGGAGGG
TTGACCAAGAGAAATGCACTGTACGGAGGCAGGATCCTCAAGTAGTATCTCCTTTCTCCCGAGGCAAACAGAACCATGTGCTAAAGAATG
TGGAAACGCACACAGGTTCTCTAATTGAACAACTAACAACAGAAAAATACGAGTGCATGGTGTGCTGTGAATTGGTTCGTGTCACGGCCC
CAGTGTGGAGTTGTCAGAGCTGTTACCATGTGTTTCATTTGAACTGCATAAAGAAATGGGCAAGGTCTCCAGCATCTCAAGCAGATGGCC
AGAGTGGTTGGAGGTGCCCTGCCTGTCAGAATGTTTCTGCACATGTTCCTAATACCTACACTTGTTTCTGTGGCAAGGTAAAGAATCCTG
AGTGGAGCAGAAATGAAATTCCACATAGCTGTGGTGAGGTTTGTAGAAAGAAACAGCCTGGCCAGGACTGCCCACATTCCTGTAACCTTC
TCTGCCATCCAGGACCCTGCCCACCCTGCCCTGCCTTTATGACAAAAACATGTGAATGTGGACGAACCAGGCACACAGTTCGCTGTGGTC
AGGCTGTCTCAGTCCACTGTTCTAACCCATGTGAGAATATTTTGAACTGTGGTCAGCACCAGTGTGCTGAGCTGTGCCATGGGGGTCAGT
GCCAGCCTTGCCAGATCATTTTGAACCAGGTATGCTATTGCGGCAGCACCTCCCGAGATGTGTTATGTGGAACCGATGTAGGAAAGTCTG
ATGGATTTGGGGATTTCAGCTGTTTAAAGATATGTGGCAAGGACTTGAAATGCGGTAACCATACATGTTCGCAAGTGTGCCACCCTCAGC
CCTGCCAGCAATGCCCACGGCTCCCCCAGCTGGTGCGCTGTTGCCCCTGTGGCCAAACTCCTCTCAGCCAATTGCTAGAACTTGGAAGTA
GTAGTCGGAAAACATGCATGGACCCTGTGCCTTCATGTGGAAAAGTGTGCGGCAAGCCTCTGCCTTGTGGTTCCTTAGTTCTGCAAATGG
GAGGTACTGGAAAGAACGTGAGGGCAGGAGGAGAGATATGCCAGGGTATTTATTGCCCTAGCTCCCCCTCTGCCAGACCACAGGTAGAAT
AGCAAGAAGTCTACATCCTGATGATCCTGGGCATTGGGAGCTCACCTCACCTTCTCTGGACTCTGGAGGGCACACACATATGGTCCCTGC
TGGGGGATGCTTCGCACACAGACCGTCTTCCAGAGGCAGGGGCAGGGAAACTGCTGTCAGAAGTGCCAGTGGCAGCAGGAAAGCTCCCTT
TCTCAAGAATGCCCATCTGTGAACACATGGTAGAGTCTCCAACCTGTTCCCAGATGTCCAACCTGGTCTGCGGCACTGATGGGCTCACAT
ATACGAATGAATGCCAGCTCTGCTTGGCCCGGATAAAAACCAAACAGGACATCCAGATCATGAAAGATGGCAAATGCTGATCCCACAGGA

>59017_59017_3_NFX1-SPINK4_NFX1_chr9_33319125_ENST00000379540_SPINK4_chr9_33218363_ENST00000379725_length(amino acids)=673AA_BP=639
MRHGMAEAPPVSGTFKFNTDAAEFIPQEKKNSGLNCGTQRRLDSNRIGRRNYSSPPPCHLSRQVPYDEISAVHQHSYHPSGSKPKSQQTS
FQSSPCNKSPKSHGLQNQPWQKLRNEKHHIRVKKAQSLAEQTSDTAGLESSTRSESGTDLREHSPSESEKEVVGADPRGAKPKKATQFVY
SYGRGPKVKGKLKCEWSNRTTPKPEDAGPESTKPVGVFHPDSSEASSRKGVLDGYGARRNEQRRYPQKRPPWEVEGARPRPGRNPPKQEG
HRHTNAGHRNNMGPIPKDDLNERPAKSTCDSENLAVINKSSRRVDQEKCTVRRQDPQVVSPFSRGKQNHVLKNVETHTGSLIEQLTTEKY
ECMVCCELVRVTAPVWSCQSCYHVFHLNCIKKWARSPASQADGQSGWRCPACQNVSAHVPNTYTCFCGKVKNPEWSRNEIPHSCGEVCRK
KQPGQDCPHSCNLLCHPGPCPPCPAFMTKTCECGRTRHTVRCGQAVSVHCSNPCENILNCGQHQCAELCHGGQCQPCQIILNQVCYCGST
SRDVLCGTDVGKSDGFGDFSCLKICGKDLKCGNHTCSQVCHPQPCQQCPRLPQLVRCCPCGQTPLSQLLELGSSSRKTCMDPVPSCGKVC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NFX1-SPINK4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneNFX1chr9:33319125chr9:33218363ENST00000318524+9169_26635.3333333333334834.0PABPC1 and PABC4
HgeneNFX1chr9:33319125chr9:33218363ENST00000379521+9219_26635.33333333333341025.0PABPC1 and PABC4
HgeneNFX1chr9:33319125chr9:33218363ENST00000379540+9249_26635.33333333333341121.0PABPC1 and PABC4
HgeneNFX1chr9:33344186chr9:33245110ENST00000318524+14169_26781.3333333333334834.0PABPC1 and PABC4
HgeneNFX1chr9:33344186chr9:33245110ENST00000379521+14219_26781.33333333333341025.0PABPC1 and PABC4
HgeneNFX1chr9:33344186chr9:33245110ENST00000379540+14249_26781.33333333333341121.0PABPC1 and PABC4


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NFX1-SPINK4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NFX1-SPINK4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource