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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NFYC-ST3GAL3 (FusionGDB2 ID:59049)

Fusion Gene Summary for NFYC-ST3GAL3

Fusion gene summary

Fusion gene information	Fusion gene name: NFYC-ST3GAL3
	Fusion gene ID: 59049
		Hgene	Tgene
	Gene symbol	NFYC	ST3GAL3
	Gene ID	4802	6487
	Gene name	nuclear transcription factor Y subunit gamma	ST3 beta-galactoside alpha-2,3-sialyltransferase 3
	Synonyms	CBF-C\|CBFC\|H1TF2A\|HAP5\|HSM\|NF-YC	EIEE15\|MRT12\|SIAT6\|ST3GALII\|ST3Gal III\|ST3GalIII\|ST3N
	Cytomap	1p34.2	1p34.1
	Type of gene	protein-coding	protein-coding
	Description	nuclear transcription factor Y subunit gammaCAAT box DNA-binding protein subunit CCCAAT binding factor subunit CCCAAT transcription binding factor subunit gammahistone H1 transcription factor large subunit 2Anuclear transcription factor Y subunit Cn	CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferaseGal beta-1,3(4)GlcNAc alpha-2,3 sialyltransferasealpha 2,3-ST 3alpha 2,3-sialyltransferase IIIalpha-2,3-sialyltransferase IIsialyltransferase 6 (N-acetyllacosaminide alpha 2,3-si
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000372654, ENST00000425457, ENST00000427410, ENST00000447388, ENST00000456393, ENST00000308733, ENST00000372651, ENST00000372652, ENST00000372653, ENST00000440226, ENST00000483091,	ENST00000262915, ENST00000330208, ENST00000332628, ENST00000335430, ENST00000347631, ENST00000351035, ENST00000353126, ENST00000361392, ENST00000361400, ENST00000361812, ENST00000372362, ENST00000372365, ENST00000372366, ENST00000372368, ENST00000372372, ENST00000372374, ENST00000372375, ENST00000372377, ENST00000531451, ENST00000545417, ENST00000461375, ENST00000361746, ENST00000372367, ENST00000372369, ENST00000528371, ENST00000531816, ENST00000531993, ENST00000533933,
Fusion gene scores	* DoF score	16 X 9 X 8=1152	13 X 15 X 10=1950
	# samples	18	15
	** MAII score	log2(18/1152*10)=-2.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/1950*10)=-3.70043971814109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NFYC [Title/Abstract] AND ST3GAL3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NFYC(41157539)-ST3GAL3(44360055), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NFYC	GO:0006355	regulation of transcription, DNA-templated	15243141

Fusion gene breakpoints across NFYC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ST3GAL3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-CD-8525-01A	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+

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Fusion Gene ORF analysis for NFYC-ST3GAL3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000372654	ENST00000262915	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000372654	ENST00000330208	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000372654	ENST00000332628	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000372654	ENST00000335430	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000372654	ENST00000347631	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000372654	ENST00000351035	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000372654	ENST00000353126	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000372654	ENST00000361392	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000372654	ENST00000361400	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000372654	ENST00000361812	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000372654	ENST00000372362	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000372654	ENST00000372365	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000372654	ENST00000372366	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000372654	ENST00000372368	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000372654	ENST00000372372	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000372654	ENST00000372374	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000372654	ENST00000372375	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000372654	ENST00000372377	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000372654	ENST00000531451	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000372654	ENST00000545417	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000425457	ENST00000262915	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000425457	ENST00000330208	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000425457	ENST00000332628	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000425457	ENST00000335430	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000425457	ENST00000347631	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000425457	ENST00000351035	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000425457	ENST00000353126	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000425457	ENST00000361392	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000425457	ENST00000361400	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000425457	ENST00000361812	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000425457	ENST00000372362	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000425457	ENST00000372365	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000425457	ENST00000372366	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000425457	ENST00000372368	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000425457	ENST00000372372	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000425457	ENST00000372374	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000425457	ENST00000372375	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000425457	ENST00000372377	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000425457	ENST00000531451	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000425457	ENST00000545417	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000427410	ENST00000262915	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000427410	ENST00000330208	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000427410	ENST00000332628	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000427410	ENST00000335430	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000427410	ENST00000347631	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000427410	ENST00000351035	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000427410	ENST00000353126	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000427410	ENST00000361392	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000427410	ENST00000361400	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000427410	ENST00000361812	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000427410	ENST00000372362	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000427410	ENST00000372365	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000427410	ENST00000372366	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000427410	ENST00000372368	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000427410	ENST00000372372	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000427410	ENST00000372374	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000427410	ENST00000372375	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000427410	ENST00000372377	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000427410	ENST00000531451	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000427410	ENST00000545417	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000447388	ENST00000262915	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000447388	ENST00000330208	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000447388	ENST00000332628	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000447388	ENST00000335430	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000447388	ENST00000347631	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000447388	ENST00000351035	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000447388	ENST00000353126	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000447388	ENST00000361392	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000447388	ENST00000361400	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000447388	ENST00000361812	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000447388	ENST00000372362	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000447388	ENST00000372365	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000447388	ENST00000372366	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000447388	ENST00000372368	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000447388	ENST00000372372	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000447388	ENST00000372374	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000447388	ENST00000372375	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000447388	ENST00000372377	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000447388	ENST00000531451	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000447388	ENST00000545417	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000456393	ENST00000262915	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000456393	ENST00000330208	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000456393	ENST00000332628	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000456393	ENST00000335430	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000456393	ENST00000347631	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000456393	ENST00000351035	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000456393	ENST00000353126	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000456393	ENST00000361392	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000456393	ENST00000361400	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000456393	ENST00000361812	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000456393	ENST00000372362	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000456393	ENST00000372365	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000456393	ENST00000372366	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000456393	ENST00000372368	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000456393	ENST00000372372	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000456393	ENST00000372374	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000456393	ENST00000372375	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000456393	ENST00000372377	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000456393	ENST00000531451	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3CDS	ENST00000456393	ENST00000545417	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3UTR	ENST00000372654	ENST00000461375	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3UTR	ENST00000425457	ENST00000461375	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3UTR	ENST00000427410	ENST00000461375	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3UTR	ENST00000447388	ENST00000461375	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-3UTR	ENST00000456393	ENST00000461375	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000372654	ENST00000361746	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000372654	ENST00000372367	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000372654	ENST00000372369	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000372654	ENST00000528371	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000372654	ENST00000531816	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000372654	ENST00000531993	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000372654	ENST00000533933	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000425457	ENST00000361746	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000425457	ENST00000372367	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000425457	ENST00000372369	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000425457	ENST00000528371	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000425457	ENST00000531816	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000425457	ENST00000531993	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000425457	ENST00000533933	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000427410	ENST00000361746	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000427410	ENST00000372367	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000427410	ENST00000372369	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000427410	ENST00000528371	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000427410	ENST00000531816	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000427410	ENST00000531993	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000427410	ENST00000533933	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000447388	ENST00000361746	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000447388	ENST00000372367	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000447388	ENST00000372369	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000447388	ENST00000528371	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000447388	ENST00000531816	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000447388	ENST00000531993	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000447388	ENST00000533933	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000456393	ENST00000361746	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000456393	ENST00000372367	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000456393	ENST00000372369	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000456393	ENST00000528371	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000456393	ENST00000531816	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000456393	ENST00000531993	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
5UTR-intron	ENST00000456393	ENST00000533933	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000308733	ENST00000262915	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000308733	ENST00000330208	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000308733	ENST00000332628	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000308733	ENST00000335430	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000308733	ENST00000347631	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000308733	ENST00000351035	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000308733	ENST00000353126	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000308733	ENST00000361392	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000308733	ENST00000361400	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000308733	ENST00000361812	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000308733	ENST00000372362	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000308733	ENST00000372365	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000308733	ENST00000372366	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000308733	ENST00000372368	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000308733	ENST00000372372	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000308733	ENST00000372374	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000308733	ENST00000372375	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000308733	ENST00000372377	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000308733	ENST00000531451	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000308733	ENST00000545417	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372651	ENST00000262915	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372651	ENST00000330208	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372651	ENST00000332628	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372651	ENST00000335430	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372651	ENST00000347631	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372651	ENST00000351035	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372651	ENST00000353126	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372651	ENST00000361392	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372651	ENST00000361400	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372651	ENST00000361812	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372651	ENST00000372362	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372651	ENST00000372365	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372651	ENST00000372366	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372651	ENST00000372368	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372651	ENST00000372372	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372651	ENST00000372374	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372651	ENST00000372375	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372651	ENST00000372377	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372651	ENST00000531451	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372651	ENST00000545417	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372652	ENST00000262915	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372652	ENST00000330208	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372652	ENST00000332628	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372652	ENST00000335430	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372652	ENST00000347631	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372652	ENST00000351035	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372652	ENST00000353126	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372652	ENST00000361392	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372652	ENST00000361400	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372652	ENST00000361812	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372652	ENST00000372362	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372652	ENST00000372365	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372652	ENST00000372366	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372652	ENST00000372368	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372652	ENST00000372372	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372652	ENST00000372374	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372652	ENST00000372375	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372652	ENST00000372377	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372652	ENST00000531451	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372652	ENST00000545417	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372653	ENST00000262915	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372653	ENST00000330208	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372653	ENST00000332628	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372653	ENST00000335430	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372653	ENST00000347631	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372653	ENST00000351035	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372653	ENST00000353126	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372653	ENST00000361392	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372653	ENST00000361400	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372653	ENST00000361812	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372653	ENST00000372362	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372653	ENST00000372365	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372653	ENST00000372366	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372653	ENST00000372368	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372653	ENST00000372372	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372653	ENST00000372374	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372653	ENST00000372375	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372653	ENST00000372377	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372653	ENST00000531451	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000372653	ENST00000545417	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000440226	ENST00000262915	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000440226	ENST00000330208	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000440226	ENST00000332628	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000440226	ENST00000335430	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000440226	ENST00000347631	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000440226	ENST00000351035	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000440226	ENST00000353126	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000440226	ENST00000361392	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000440226	ENST00000361400	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000440226	ENST00000361812	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000440226	ENST00000372362	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000440226	ENST00000372365	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000440226	ENST00000372366	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000440226	ENST00000372368	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000440226	ENST00000372372	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000440226	ENST00000372374	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000440226	ENST00000372375	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000440226	ENST00000372377	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000440226	ENST00000531451	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000440226	ENST00000545417	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000483091	ENST00000262915	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000483091	ENST00000330208	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000483091	ENST00000332628	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000483091	ENST00000335430	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000483091	ENST00000347631	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000483091	ENST00000351035	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000483091	ENST00000353126	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000483091	ENST00000361392	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000483091	ENST00000361400	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000483091	ENST00000361812	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000483091	ENST00000372362	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000483091	ENST00000372365	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000483091	ENST00000372366	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000483091	ENST00000372368	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000483091	ENST00000372372	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000483091	ENST00000372374	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000483091	ENST00000372375	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000483091	ENST00000372377	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000483091	ENST00000531451	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3CDS	ENST00000483091	ENST00000545417	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3UTR	ENST00000308733	ENST00000461375	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3UTR	ENST00000372651	ENST00000461375	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3UTR	ENST00000372652	ENST00000461375	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3UTR	ENST00000372653	ENST00000461375	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3UTR	ENST00000440226	ENST00000461375	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-3UTR	ENST00000483091	ENST00000461375	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000308733	ENST00000361746	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000308733	ENST00000372367	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000308733	ENST00000372369	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000308733	ENST00000528371	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000308733	ENST00000531816	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000308733	ENST00000531993	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000308733	ENST00000533933	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000372651	ENST00000361746	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000372651	ENST00000372367	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000372651	ENST00000372369	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000372651	ENST00000528371	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000372651	ENST00000531816	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000372651	ENST00000531993	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000372651	ENST00000533933	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000372652	ENST00000361746	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000372652	ENST00000372367	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000372652	ENST00000372369	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000372652	ENST00000528371	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000372652	ENST00000531816	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000372652	ENST00000531993	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000372652	ENST00000533933	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000372653	ENST00000361746	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000372653	ENST00000372367	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000372653	ENST00000372369	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000372653	ENST00000528371	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000372653	ENST00000531816	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000372653	ENST00000531993	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000372653	ENST00000533933	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000440226	ENST00000361746	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000440226	ENST00000372367	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000440226	ENST00000372369	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000440226	ENST00000528371	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000440226	ENST00000531816	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000440226	ENST00000531993	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000440226	ENST00000533933	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000483091	ENST00000361746	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000483091	ENST00000372367	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000483091	ENST00000372369	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000483091	ENST00000528371	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000483091	ENST00000531816	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000483091	ENST00000531993	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+
intron-intron	ENST00000483091	ENST00000533933	NFYC	chr1	41157539	+	ST3GAL3	chr1	44360055	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for NFYC-ST3GAL3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
NFYC	chr1	41157539	+	ST3GAL3	chr1	44360054	+	0.003347522	0.99665254
NFYC	chr1	41157539	+	ST3GAL3	chr1	44360054	+	0.003347522	0.99665254

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NFYC-ST3GAL3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:41157539/:44360055)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for NFYC-ST3GAL3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NFYC-ST3GAL3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for NFYC-ST3GAL3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for NFYC-ST3GAL3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source