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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NHLRC3-EDEM2 (FusionGDB2 ID:59076)

Fusion Gene Summary for NHLRC3-EDEM2

check button Fusion gene summary
Fusion gene informationFusion gene name: NHLRC3-EDEM2
Fusion gene ID: 59076
HgeneTgene
Gene symbol

NHLRC3

EDEM2

Gene ID

387921

55741

Gene nameNHL repeat containing 3ER degradation enhancing alpha-mannosidase like protein 2
Synonyms-C20orf31|C20orf49|bA4204.1
Cytomap

13q13.3

20q11.22

Type of geneprotein-codingprotein-coding
DescriptionNHL repeat-containing protein 3ER degradation-enhancing alpha-mannosidase-like protein 2ER degradation enhancer, mannosidase alpha-like 2ER degradation-enhancing alpha-mannosidase-like 2ER degradation-enhancing-mannosidase-like protein 2
Modification date2020031320200313
UniProtAcc.

Q9BV94

Ensembl transtripts involved in fusion geneENST00000470258, ENST00000379599, 
ENST00000379600, 		ENST00000374491, 
ENST00000374492, ENST00000540582, 
ENST00000541621, ENST00000542871, 
Fusion gene scores* DoF score8 X 3 X 4=967 X 7 X 6=294
# samples 79
** MAII scorelog2(7/96*10)=-0.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/294*10)=-1.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NHLRC3 [Title/Abstract] AND EDEM2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNHLRC3(39613848)-EDEM2(33714178), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NHLRC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EDEM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-B0-5102-01ANHLRC3chr13

39613848

+EDEM2chr20

33714178

-


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Fusion Gene ORF analysis for NHLRC3-EDEM2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000470258ENST00000374491NHLRC3chr13

39613848

+EDEM2chr20

33714178

-
5UTR-3CDSENST00000470258ENST00000374492NHLRC3chr13

39613848

+EDEM2chr20

33714178

-
5UTR-3CDSENST00000470258ENST00000540582NHLRC3chr13

39613848

+EDEM2chr20

33714178

-
5UTR-3CDSENST00000470258ENST00000541621NHLRC3chr13

39613848

+EDEM2chr20

33714178

-
5UTR-3CDSENST00000470258ENST00000542871NHLRC3chr13

39613848

+EDEM2chr20

33714178

-
In-frameENST00000379599ENST00000374491NHLRC3chr13

39613848

+EDEM2chr20

33714178

-
In-frameENST00000379599ENST00000374492NHLRC3chr13

39613848

+EDEM2chr20

33714178

-
In-frameENST00000379599ENST00000540582NHLRC3chr13

39613848

+EDEM2chr20

33714178

-
In-frameENST00000379599ENST00000541621NHLRC3chr13

39613848

+EDEM2chr20

33714178

-
In-frameENST00000379599ENST00000542871NHLRC3chr13

39613848

+EDEM2chr20

33714178

-
In-frameENST00000379600ENST00000374491NHLRC3chr13

39613848

+EDEM2chr20

33714178

-
In-frameENST00000379600ENST00000374492NHLRC3chr13

39613848

+EDEM2chr20

33714178

-
In-frameENST00000379600ENST00000540582NHLRC3chr13

39613848

+EDEM2chr20

33714178

-
In-frameENST00000379600ENST00000541621NHLRC3chr13

39613848

+EDEM2chr20

33714178

-
In-frameENST00000379600ENST00000542871NHLRC3chr13

39613848

+EDEM2chr20

33714178

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379600NHLRC3chr1339613848+ENST00000540582EDEM2chr2033714178-16727071451200351
ENST00000379600NHLRC3chr1339613848+ENST00000374491EDEM2chr2033714178-16697071451599484
ENST00000379600NHLRC3chr1339613848+ENST00000374492EDEM2chr2033714178-16697071451599484
ENST00000379600NHLRC3chr1339613848+ENST00000541621EDEM2chr2033714178-16687071451599484
ENST00000379600NHLRC3chr1339613848+ENST00000542871EDEM2chr2033714178-16667071451599484
ENST00000379599NHLRC3chr1339613848+ENST00000540582EDEM2chr2033714178-1599634721127351
ENST00000379599NHLRC3chr1339613848+ENST00000374491EDEM2chr2033714178-1596634721526484
ENST00000379599NHLRC3chr1339613848+ENST00000374492EDEM2chr2033714178-1596634721526484
ENST00000379599NHLRC3chr1339613848+ENST00000541621EDEM2chr2033714178-1595634721526484
ENST00000379599NHLRC3chr1339613848+ENST00000542871EDEM2chr2033714178-1593634721526484

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379600ENST00000540582NHLRC3chr1339613848+EDEM2chr2033714178-0.0020021310.9979978
ENST00000379600ENST00000374491NHLRC3chr1339613848+EDEM2chr2033714178-0.0017377480.9982622
ENST00000379600ENST00000374492NHLRC3chr1339613848+EDEM2chr2033714178-0.0017377480.9982622
ENST00000379600ENST00000541621NHLRC3chr1339613848+EDEM2chr2033714178-0.0017631610.9982368
ENST00000379600ENST00000542871NHLRC3chr1339613848+EDEM2chr2033714178-0.0017648850.9982351
ENST00000379599ENST00000540582NHLRC3chr1339613848+EDEM2chr2033714178-0.0019092860.9980907
ENST00000379599ENST00000374491NHLRC3chr1339613848+EDEM2chr2033714178-0.0015305670.9984694
ENST00000379599ENST00000374492NHLRC3chr1339613848+EDEM2chr2033714178-0.0015305670.9984694
ENST00000379599ENST00000541621NHLRC3chr1339613848+EDEM2chr2033714178-0.0015485560.9984515
ENST00000379599ENST00000542871NHLRC3chr1339613848+EDEM2chr2033714178-0.0015469420.998453

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Fusion Genomic Features for NHLRC3-EDEM2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NHLRC3-EDEM2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:39613848/chr20:33714178)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EDEM2

Q9BV94

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner (PubMed:15537790, PubMed:25092655). May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655). Seems to recognize and bind to exposed hydrophobic regions in target proteins (By similarity). {ECO:0000250|UniProtKB:Q8BJT9, ECO:0000269|PubMed:15537790, ECO:0000269|PubMed:25092655}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNHLRC3chr13:39613848chr20:33714178ENST00000379599+3647_93128281.0RepeatNote=NHL 1
HgeneNHLRC3chr13:39613848chr20:33714178ENST00000379600+3747_93128348.0RepeatNote=NHL 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNHLRC3chr13:39613848chr20:33714178ENST00000379599+36150_196128281.0RepeatNote=NHL 2
HgeneNHLRC3chr13:39613848chr20:33714178ENST00000379599+36200_243128281.0RepeatNote=NHL 3
HgeneNHLRC3chr13:39613848chr20:33714178ENST00000379599+36294_338128281.0RepeatNote=NHL 4
HgeneNHLRC3chr13:39613848chr20:33714178ENST00000379600+37150_196128348.0RepeatNote=NHL 2
HgeneNHLRC3chr13:39613848chr20:33714178ENST00000379600+37200_243128348.0RepeatNote=NHL 3
HgeneNHLRC3chr13:39613848chr20:33714178ENST00000379600+37294_338128348.0RepeatNote=NHL 4


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Fusion Gene Sequence for NHLRC3-EDEM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>59076_59076_1_NHLRC3-EDEM2_NHLRC3_chr13_39613848_ENST00000379599_EDEM2_chr20_33714178_ENST00000374491_length(transcript)=1596nt_BP=634nt
ACCTGACATGAGGGCGGGGACCCCGAAATGCACACGAAGTCCGGAACTGGTCTTCTGTGATTTTCATTCGCCCTGGTCTCTGTTCCCTTT
CGTACTCAAAGCTCGTGCATCCAGGGAGGGGAAACCGGAGATAGGGTCTTCGGGCCCCGGGCAGACCCTCTGTGCCGCTGCAAACCGTTG
CAGCCTGAGGCTGTCAGGTCCTCCCCCAGACACCTGCGGACCCTCCCTCTCCTGGCTTCCCGTCTGGTCATGGCGAGATTCTGGGTCTGC
GTAGCCGGTGCTGGCTTCTTTCTTGCATTTTTGGTTTTGCATTCGCGTTTTTGTGGCTCTCCAGTTTTGAGGAACTTTACTTTTGCAGTT
TCCTGGAGAACTGAGAAAATTCTTTACCGGCTGGATGTGGGTTGGCCTAAGCACCCAGAATATTTTACCGGAACAACATTTTGTGTTGCA
GTTGACTCCCTCAATGGATTGGTTTACATAGGTCAAAGAGGGGATAACATCCCAAAGATATTAGTGTTCACAGAGGATGGATATTTCCTA
CGAGCCTGGAATTATACAGTTGACACACCTCATGGTATATTTGCAGCCAGTACTCTATATGAACAATCCGTCTGGATCACGGATGTAGGA
AGTGAGTATAACAAAGCCATCCGGAACTACACCCGCTTCGATGACTGGTACCTGTGGGTTCAGATGTACAAGGGGACTGTGTCCATGCCA
GTCTTCCAGTCCTTGGAGGCCTACTGGCCTGGTCTTCAGAGCCTCATTGGAGACATTGACAATGCCATGAGGACCTTCCTCAACTACTAC
ACTGTATGGAAGCAGTTTGGGGGGCTCCCGGAATTCTACAACATTCCTCAGGGATACACAGTGGAGAAGCGAGAGGGCTACCCACTTCGG
CCAGAACTTATTGAAAGCGCAATGTACCTCTACCGTGCCACGGGGGATCCCACCCTCCTAGAACTCGGAAGAGATGCTGTGGAATCCATT
GAAAAAATCAGCAAGGTGGAGTGCGGATTTGCAACAATCAAAGATCTGCGAGACCACAAGCTGGACAACCGCATGGAGTCGTTCTTCCTG
GCCGAGACTGTGAAATACCTCTACCTCCTGTTTGACCCAACCAACTTCATCCACAACAATGGGTCCACCTTCGACGCGGTGATCACCCCC
TATGGGGAGTGCATCCTGGGGGCTGGGGGGTACATCTTCAACACAGAAGCTCACCCCATCGACCCTGCCGCCCTGCACTGCTGCCAGAGG
CTGAAGGAAGAGCAGTGGGAGGTGGAGGACTTGATGAGGGAATTCTACTCTCTCAAACGGAGCAGGTCGAAATTTCAGAAAAACACTGTT
AGTTCGGGGCCATGGGAACCTCCAGCAAGGCCAGGAACACTCTTCTCACCAGAAAACCATGACCAGGCAAGGGAGAGGAAGCCTGCCAAA
CAGAAGGTCCCACTTCTCAGCTGCCCCAGTCAGCCCTTCACCTCCAAGTTGGCATTACTGGGACAGGTTTTCCTAGACTCCTCATAACCA

>59076_59076_1_NHLRC3-EDEM2_NHLRC3_chr13_39613848_ENST00000379599_EDEM2_chr20_33714178_ENST00000374491_length(amino acids)=484AA_BP=187
MVSVPFRTQSSCIQGGETGDRVFGPRADPLCRCKPLQPEAVRSSPRHLRTLPLLASRLVMARFWVCVAGAGFFLAFLVLHSRFCGSPVLR
NFTFAVSWRTEKILYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVFTEDGYFLRAWNYTVDTPHGIFAASTLYEQSV
WITDVGSEYNKAIRNYTRFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKR
EGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTF
DAVITPYGECILGAGGYIFNTEAHPIDPAALHCCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENHDQAR

--------------------------------------------------------------
>59076_59076_2_NHLRC3-EDEM2_NHLRC3_chr13_39613848_ENST00000379599_EDEM2_chr20_33714178_ENST00000374492_length(transcript)=1596nt_BP=634nt
ACCTGACATGAGGGCGGGGACCCCGAAATGCACACGAAGTCCGGAACTGGTCTTCTGTGATTTTCATTCGCCCTGGTCTCTGTTCCCTTT
CGTACTCAAAGCTCGTGCATCCAGGGAGGGGAAACCGGAGATAGGGTCTTCGGGCCCCGGGCAGACCCTCTGTGCCGCTGCAAACCGTTG
CAGCCTGAGGCTGTCAGGTCCTCCCCCAGACACCTGCGGACCCTCCCTCTCCTGGCTTCCCGTCTGGTCATGGCGAGATTCTGGGTCTGC
GTAGCCGGTGCTGGCTTCTTTCTTGCATTTTTGGTTTTGCATTCGCGTTTTTGTGGCTCTCCAGTTTTGAGGAACTTTACTTTTGCAGTT
TCCTGGAGAACTGAGAAAATTCTTTACCGGCTGGATGTGGGTTGGCCTAAGCACCCAGAATATTTTACCGGAACAACATTTTGTGTTGCA
GTTGACTCCCTCAATGGATTGGTTTACATAGGTCAAAGAGGGGATAACATCCCAAAGATATTAGTGTTCACAGAGGATGGATATTTCCTA
CGAGCCTGGAATTATACAGTTGACACACCTCATGGTATATTTGCAGCCAGTACTCTATATGAACAATCCGTCTGGATCACGGATGTAGGA
AGTGAGTATAACAAAGCCATCCGGAACTACACCCGCTTCGATGACTGGTACCTGTGGGTTCAGATGTACAAGGGGACTGTGTCCATGCCA
GTCTTCCAGTCCTTGGAGGCCTACTGGCCTGGTCTTCAGAGCCTCATTGGAGACATTGACAATGCCATGAGGACCTTCCTCAACTACTAC
ACTGTATGGAAGCAGTTTGGGGGGCTCCCGGAATTCTACAACATTCCTCAGGGATACACAGTGGAGAAGCGAGAGGGCTACCCACTTCGG
CCAGAACTTATTGAAAGCGCAATGTACCTCTACCGTGCCACGGGGGATCCCACCCTCCTAGAACTCGGAAGAGATGCTGTGGAATCCATT
GAAAAAATCAGCAAGGTGGAGTGCGGATTTGCAACAATCAAAGATCTGCGAGACCACAAGCTGGACAACCGCATGGAGTCGTTCTTCCTG
GCCGAGACTGTGAAATACCTCTACCTCCTGTTTGACCCAACCAACTTCATCCACAACAATGGGTCCACCTTCGACGCGGTGATCACCCCC
TATGGGGAGTGCATCCTGGGGGCTGGGGGGTACATCTTCAACACAGAAGCTCACCCCATCGACCCTGCCGCCCTGCACTGCTGCCAGAGG
CTGAAGGAAGAGCAGTGGGAGGTGGAGGACTTGATGAGGGAATTCTACTCTCTCAAACGGAGCAGGTCGAAATTTCAGAAAAACACTGTT
AGTTCGGGGCCATGGGAACCTCCAGCAAGGCCAGGAACACTCTTCTCACCAGAAAACCATGACCAGGCAAGGGAGAGGAAGCCTGCCAAA
CAGAAGGTCCCACTTCTCAGCTGCCCCAGTCAGCCCTTCACCTCCAAGTTGGCATTACTGGGACAGGTTTTCCTAGACTCCTCATAACCA

>59076_59076_2_NHLRC3-EDEM2_NHLRC3_chr13_39613848_ENST00000379599_EDEM2_chr20_33714178_ENST00000374492_length(amino acids)=484AA_BP=187
MVSVPFRTQSSCIQGGETGDRVFGPRADPLCRCKPLQPEAVRSSPRHLRTLPLLASRLVMARFWVCVAGAGFFLAFLVLHSRFCGSPVLR
NFTFAVSWRTEKILYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVFTEDGYFLRAWNYTVDTPHGIFAASTLYEQSV
WITDVGSEYNKAIRNYTRFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKR
EGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTF
DAVITPYGECILGAGGYIFNTEAHPIDPAALHCCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENHDQAR

--------------------------------------------------------------
>59076_59076_3_NHLRC3-EDEM2_NHLRC3_chr13_39613848_ENST00000379599_EDEM2_chr20_33714178_ENST00000540582_length(transcript)=1599nt_BP=634nt
ACCTGACATGAGGGCGGGGACCCCGAAATGCACACGAAGTCCGGAACTGGTCTTCTGTGATTTTCATTCGCCCTGGTCTCTGTTCCCTTT
CGTACTCAAAGCTCGTGCATCCAGGGAGGGGAAACCGGAGATAGGGTCTTCGGGCCCCGGGCAGACCCTCTGTGCCGCTGCAAACCGTTG
CAGCCTGAGGCTGTCAGGTCCTCCCCCAGACACCTGCGGACCCTCCCTCTCCTGGCTTCCCGTCTGGTCATGGCGAGATTCTGGGTCTGC
GTAGCCGGTGCTGGCTTCTTTCTTGCATTTTTGGTTTTGCATTCGCGTTTTTGTGGCTCTCCAGTTTTGAGGAACTTTACTTTTGCAGTT
TCCTGGAGAACTGAGAAAATTCTTTACCGGCTGGATGTGGGTTGGCCTAAGCACCCAGAATATTTTACCGGAACAACATTTTGTGTTGCA
GTTGACTCCCTCAATGGATTGGTTTACATAGGTCAAAGAGGGGATAACATCCCAAAGATATTAGTGTTCACAGAGGATGGATATTTCCTA
CGAGCCTGGAATTATACAGTTGACACACCTCATGGTATATTTGCAGCCAGTACTCTATATGAACAATCCGTCTGGATCACGGATGTAGGA
AGTGAGTATAACAAAGCCATCCGGAACTACACCCGCTTCGATGACTGGTACCTGTGGGTTCAGATGTACAAGGGGACTGTGTCCATGCCA
GTCTTCCAGTCCTTGGAGGCCTACTGGCCTGGTCTTCAGAGCCTCATTGGAGACATTGACAATGCCATGAGGACCTTCCTCAACTACTAC
ACTGTATGGAAGCAGTTTGGGGGGCTCCCGGAATTCTACAACATTCCTCAGGGATACACAGTGGAGAAGCGAGAGGGCTACCCACTTCGG
CCAGAACTTATTGAAAGCGCAATGTACCTCTACCGTGCCACGGGGGATCCCACCCTCCTAGAACTCGGAAGAGATGCTGTGGAATCCATT
GAAAAAATCAGCAAGGTGGAGTGCGGATTTGCAACAGTAAGTGTTTGCATGGCCCCAAGAACTGGGAAGAGTCTCCCCTTGCTGCTAAAA
AGCCTCTTTAAGGGTAGAGCTTTGGGAGTTCTGACATATCAGCACTAGAAGGGACCTTGGAGATATACATAATGCTCATATTTTACAGAT
GGGGAGACCAAAGAACAGAGAAGCTAAGTGCCTTGCTAAAGATCTCACAGCTAGTAGAGGTAGAGCTAGAATTAGTTCCTTGGGATCTTG
ACCCCGGCCCTTGGCATTCCTCCCACAGTGGAGATCTTTGATCTGTTTGAATAGGTGACTTTGAAAAGGTGAGTTTAGCGAAAAGTTTTG
TGAGACACTAAAATAGATTTTAAGGGGAATCCAGAGTCCCATAGCCCTATATTCAAACCTGGGACTCCTTAACAAAGCAGTCCTGCTTAG
TCTCACAGATATTTCTTGAATGTCTTTCACATGCCAGGCACTCTGCTAGGCCCAAGGGTTACAGCAGTGGCCTTGCTCTCATGGAGCTTA

>59076_59076_3_NHLRC3-EDEM2_NHLRC3_chr13_39613848_ENST00000379599_EDEM2_chr20_33714178_ENST00000540582_length(amino acids)=351AA_BP=187
MVSVPFRTQSSCIQGGETGDRVFGPRADPLCRCKPLQPEAVRSSPRHLRTLPLLASRLVMARFWVCVAGAGFFLAFLVLHSRFCGSPVLR
NFTFAVSWRTEKILYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVFTEDGYFLRAWNYTVDTPHGIFAASTLYEQSV
WITDVGSEYNKAIRNYTRFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKR

--------------------------------------------------------------
>59076_59076_4_NHLRC3-EDEM2_NHLRC3_chr13_39613848_ENST00000379599_EDEM2_chr20_33714178_ENST00000541621_length(transcript)=1595nt_BP=634nt
ACCTGACATGAGGGCGGGGACCCCGAAATGCACACGAAGTCCGGAACTGGTCTTCTGTGATTTTCATTCGCCCTGGTCTCTGTTCCCTTT
CGTACTCAAAGCTCGTGCATCCAGGGAGGGGAAACCGGAGATAGGGTCTTCGGGCCCCGGGCAGACCCTCTGTGCCGCTGCAAACCGTTG
CAGCCTGAGGCTGTCAGGTCCTCCCCCAGACACCTGCGGACCCTCCCTCTCCTGGCTTCCCGTCTGGTCATGGCGAGATTCTGGGTCTGC
GTAGCCGGTGCTGGCTTCTTTCTTGCATTTTTGGTTTTGCATTCGCGTTTTTGTGGCTCTCCAGTTTTGAGGAACTTTACTTTTGCAGTT
TCCTGGAGAACTGAGAAAATTCTTTACCGGCTGGATGTGGGTTGGCCTAAGCACCCAGAATATTTTACCGGAACAACATTTTGTGTTGCA
GTTGACTCCCTCAATGGATTGGTTTACATAGGTCAAAGAGGGGATAACATCCCAAAGATATTAGTGTTCACAGAGGATGGATATTTCCTA
CGAGCCTGGAATTATACAGTTGACACACCTCATGGTATATTTGCAGCCAGTACTCTATATGAACAATCCGTCTGGATCACGGATGTAGGA
AGTGAGTATAACAAAGCCATCCGGAACTACACCCGCTTCGATGACTGGTACCTGTGGGTTCAGATGTACAAGGGGACTGTGTCCATGCCA
GTCTTCCAGTCCTTGGAGGCCTACTGGCCTGGTCTTCAGAGCCTCATTGGAGACATTGACAATGCCATGAGGACCTTCCTCAACTACTAC
ACTGTATGGAAGCAGTTTGGGGGGCTCCCGGAATTCTACAACATTCCTCAGGGATACACAGTGGAGAAGCGAGAGGGCTACCCACTTCGG
CCAGAACTTATTGAAAGCGCAATGTACCTCTACCGTGCCACGGGGGATCCCACCCTCCTAGAACTCGGAAGAGATGCTGTGGAATCCATT
GAAAAAATCAGCAAGGTGGAGTGCGGATTTGCAACAATCAAAGATCTGCGAGACCACAAGCTGGACAACCGCATGGAGTCGTTCTTCCTG
GCCGAGACTGTGAAATACCTCTACCTCCTGTTTGACCCAACCAACTTCATCCACAACAATGGGTCCACCTTCGACGCGGTGATCACCCCC
TATGGGGAGTGCATCCTGGGGGCTGGGGGGTACATCTTCAACACAGAAGCTCACCCCATCGACCCTGCCGCCCTGCACTGCTGCCAGAGG
CTGAAGGAAGAGCAGTGGGAGGTGGAGGACTTGATGAGGGAATTCTACTCTCTCAAACGGAGCAGGTCGAAATTTCAGAAAAACACTGTT
AGTTCGGGGCCATGGGAACCTCCAGCAAGGCCAGGAACACTCTTCTCACCAGAAAACCATGACCAGGCAAGGGAGAGGAAGCCTGCCAAA
CAGAAGGTCCCACTTCTCAGCTGCCCCAGTCAGCCCTTCACCTCCAAGTTGGCATTACTGGGACAGGTTTTCCTAGACTCCTCATAACCA

>59076_59076_4_NHLRC3-EDEM2_NHLRC3_chr13_39613848_ENST00000379599_EDEM2_chr20_33714178_ENST00000541621_length(amino acids)=484AA_BP=187
MVSVPFRTQSSCIQGGETGDRVFGPRADPLCRCKPLQPEAVRSSPRHLRTLPLLASRLVMARFWVCVAGAGFFLAFLVLHSRFCGSPVLR
NFTFAVSWRTEKILYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVFTEDGYFLRAWNYTVDTPHGIFAASTLYEQSV
WITDVGSEYNKAIRNYTRFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKR
EGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTF
DAVITPYGECILGAGGYIFNTEAHPIDPAALHCCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENHDQAR

--------------------------------------------------------------
>59076_59076_5_NHLRC3-EDEM2_NHLRC3_chr13_39613848_ENST00000379599_EDEM2_chr20_33714178_ENST00000542871_length(transcript)=1593nt_BP=634nt
ACCTGACATGAGGGCGGGGACCCCGAAATGCACACGAAGTCCGGAACTGGTCTTCTGTGATTTTCATTCGCCCTGGTCTCTGTTCCCTTT
CGTACTCAAAGCTCGTGCATCCAGGGAGGGGAAACCGGAGATAGGGTCTTCGGGCCCCGGGCAGACCCTCTGTGCCGCTGCAAACCGTTG
CAGCCTGAGGCTGTCAGGTCCTCCCCCAGACACCTGCGGACCCTCCCTCTCCTGGCTTCCCGTCTGGTCATGGCGAGATTCTGGGTCTGC
GTAGCCGGTGCTGGCTTCTTTCTTGCATTTTTGGTTTTGCATTCGCGTTTTTGTGGCTCTCCAGTTTTGAGGAACTTTACTTTTGCAGTT
TCCTGGAGAACTGAGAAAATTCTTTACCGGCTGGATGTGGGTTGGCCTAAGCACCCAGAATATTTTACCGGAACAACATTTTGTGTTGCA
GTTGACTCCCTCAATGGATTGGTTTACATAGGTCAAAGAGGGGATAACATCCCAAAGATATTAGTGTTCACAGAGGATGGATATTTCCTA
CGAGCCTGGAATTATACAGTTGACACACCTCATGGTATATTTGCAGCCAGTACTCTATATGAACAATCCGTCTGGATCACGGATGTAGGA
AGTGAGTATAACAAAGCCATCCGGAACTACACCCGCTTCGATGACTGGTACCTGTGGGTTCAGATGTACAAGGGGACTGTGTCCATGCCA
GTCTTCCAGTCCTTGGAGGCCTACTGGCCTGGTCTTCAGAGCCTCATTGGAGACATTGACAATGCCATGAGGACCTTCCTCAACTACTAC
ACTGTATGGAAGCAGTTTGGGGGGCTCCCGGAATTCTACAACATTCCTCAGGGATACACAGTGGAGAAGCGAGAGGGCTACCCACTTCGG
CCAGAACTTATTGAAAGCGCAATGTACCTCTACCGTGCCACGGGGGATCCCACCCTCCTAGAACTCGGAAGAGATGCTGTGGAATCCATT
GAAAAAATCAGCAAGGTGGAGTGCGGATTTGCAACAATCAAAGATCTGCGAGACCACAAGCTGGACAACCGCATGGAGTCGTTCTTCCTG
GCCGAGACTGTGAAATACCTCTACCTCCTGTTTGACCCAACCAACTTCATCCACAACAATGGGTCCACCTTCGACGCGGTGATCACCCCC
TATGGGGAGTGCATCCTGGGGGCTGGGGGGTACATCTTCAACACAGAAGCTCACCCCATCGACCCTGCCGCCCTGCACTGCTGCCAGAGG
CTGAAGGAAGAGCAGTGGGAGGTGGAGGACTTGATGAGGGAATTCTACTCTCTCAAACGGAGCAGGTCGAAATTTCAGAAAAACACTGTT
AGTTCGGGGCCATGGGAACCTCCAGCAAGGCCAGGAACACTCTTCTCACCAGAAAACCATGACCAGGCAAGGGAGAGGAAGCCTGCCAAA
CAGAAGGTCCCACTTCTCAGCTGCCCCAGTCAGCCCTTCACCTCCAAGTTGGCATTACTGGGACAGGTTTTCCTAGACTCCTCATAACCA

>59076_59076_5_NHLRC3-EDEM2_NHLRC3_chr13_39613848_ENST00000379599_EDEM2_chr20_33714178_ENST00000542871_length(amino acids)=484AA_BP=187
MVSVPFRTQSSCIQGGETGDRVFGPRADPLCRCKPLQPEAVRSSPRHLRTLPLLASRLVMARFWVCVAGAGFFLAFLVLHSRFCGSPVLR
NFTFAVSWRTEKILYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVFTEDGYFLRAWNYTVDTPHGIFAASTLYEQSV
WITDVGSEYNKAIRNYTRFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKR
EGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTF
DAVITPYGECILGAGGYIFNTEAHPIDPAALHCCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENHDQAR

--------------------------------------------------------------
>59076_59076_6_NHLRC3-EDEM2_NHLRC3_chr13_39613848_ENST00000379600_EDEM2_chr20_33714178_ENST00000374491_length(transcript)=1669nt_BP=707nt
GGTGGCCACTGAAAGTCAGCGGCGCGGACTGCCCTGAGGGCGGGAAAGGGTGGTCACTGGGTCAGCCCGAAGCACCTGACATGAGGGCGG
GGACCCCGAAATGCACACGAAGTCCGGAACTGGTCTTCTGTGATTTTCATTCGCCCTGGTCTCTGTTCCCTTTCGTACTCAAAGCTCGTG
CATCCAGGGAGGGGAAACCGGAGATAGGGTCTTCGGGCCCCGGGCAGACCCTCTGTGCCGCTGCAAACCGTTGCAGCCTGAGGCTGTCAG
GTCCTCCCCCAGACACCTGCGGACCCTCCCTCTCCTGGCTTCCCGTCTGGTCATGGCGAGATTCTGGGTCTGCGTAGCCGGTGCTGGCTT
CTTTCTTGCATTTTTGGTTTTGCATTCGCGTTTTTGTGGCTCTCCAGTTTTGAGGAACTTTACTTTTGCAGTTTCCTGGAGAACTGAGAA
AATTCTTTACCGGCTGGATGTGGGTTGGCCTAAGCACCCAGAATATTTTACCGGAACAACATTTTGTGTTGCAGTTGACTCCCTCAATGG
ATTGGTTTACATAGGTCAAAGAGGGGATAACATCCCAAAGATATTAGTGTTCACAGAGGATGGATATTTCCTACGAGCCTGGAATTATAC
AGTTGACACACCTCATGGTATATTTGCAGCCAGTACTCTATATGAACAATCCGTCTGGATCACGGATGTAGGAAGTGAGTATAACAAAGC
CATCCGGAACTACACCCGCTTCGATGACTGGTACCTGTGGGTTCAGATGTACAAGGGGACTGTGTCCATGCCAGTCTTCCAGTCCTTGGA
GGCCTACTGGCCTGGTCTTCAGAGCCTCATTGGAGACATTGACAATGCCATGAGGACCTTCCTCAACTACTACACTGTATGGAAGCAGTT
TGGGGGGCTCCCGGAATTCTACAACATTCCTCAGGGATACACAGTGGAGAAGCGAGAGGGCTACCCACTTCGGCCAGAACTTATTGAAAG
CGCAATGTACCTCTACCGTGCCACGGGGGATCCCACCCTCCTAGAACTCGGAAGAGATGCTGTGGAATCCATTGAAAAAATCAGCAAGGT
GGAGTGCGGATTTGCAACAATCAAAGATCTGCGAGACCACAAGCTGGACAACCGCATGGAGTCGTTCTTCCTGGCCGAGACTGTGAAATA
CCTCTACCTCCTGTTTGACCCAACCAACTTCATCCACAACAATGGGTCCACCTTCGACGCGGTGATCACCCCCTATGGGGAGTGCATCCT
GGGGGCTGGGGGGTACATCTTCAACACAGAAGCTCACCCCATCGACCCTGCCGCCCTGCACTGCTGCCAGAGGCTGAAGGAAGAGCAGTG
GGAGGTGGAGGACTTGATGAGGGAATTCTACTCTCTCAAACGGAGCAGGTCGAAATTTCAGAAAAACACTGTTAGTTCGGGGCCATGGGA
ACCTCCAGCAAGGCCAGGAACACTCTTCTCACCAGAAAACCATGACCAGGCAAGGGAGAGGAAGCCTGCCAAACAGAAGGTCCCACTTCT
CAGCTGCCCCAGTCAGCCCTTCACCTCCAAGTTGGCATTACTGGGACAGGTTTTCCTAGACTCCTCATAACCACTGGATAATTTTTTTAT

>59076_59076_6_NHLRC3-EDEM2_NHLRC3_chr13_39613848_ENST00000379600_EDEM2_chr20_33714178_ENST00000374491_length(amino acids)=484AA_BP=187
MVSVPFRTQSSCIQGGETGDRVFGPRADPLCRCKPLQPEAVRSSPRHLRTLPLLASRLVMARFWVCVAGAGFFLAFLVLHSRFCGSPVLR
NFTFAVSWRTEKILYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVFTEDGYFLRAWNYTVDTPHGIFAASTLYEQSV
WITDVGSEYNKAIRNYTRFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKR
EGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTF
DAVITPYGECILGAGGYIFNTEAHPIDPAALHCCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENHDQAR

--------------------------------------------------------------
>59076_59076_7_NHLRC3-EDEM2_NHLRC3_chr13_39613848_ENST00000379600_EDEM2_chr20_33714178_ENST00000374492_length(transcript)=1669nt_BP=707nt
GGTGGCCACTGAAAGTCAGCGGCGCGGACTGCCCTGAGGGCGGGAAAGGGTGGTCACTGGGTCAGCCCGAAGCACCTGACATGAGGGCGG
GGACCCCGAAATGCACACGAAGTCCGGAACTGGTCTTCTGTGATTTTCATTCGCCCTGGTCTCTGTTCCCTTTCGTACTCAAAGCTCGTG
CATCCAGGGAGGGGAAACCGGAGATAGGGTCTTCGGGCCCCGGGCAGACCCTCTGTGCCGCTGCAAACCGTTGCAGCCTGAGGCTGTCAG
GTCCTCCCCCAGACACCTGCGGACCCTCCCTCTCCTGGCTTCCCGTCTGGTCATGGCGAGATTCTGGGTCTGCGTAGCCGGTGCTGGCTT
CTTTCTTGCATTTTTGGTTTTGCATTCGCGTTTTTGTGGCTCTCCAGTTTTGAGGAACTTTACTTTTGCAGTTTCCTGGAGAACTGAGAA
AATTCTTTACCGGCTGGATGTGGGTTGGCCTAAGCACCCAGAATATTTTACCGGAACAACATTTTGTGTTGCAGTTGACTCCCTCAATGG
ATTGGTTTACATAGGTCAAAGAGGGGATAACATCCCAAAGATATTAGTGTTCACAGAGGATGGATATTTCCTACGAGCCTGGAATTATAC
AGTTGACACACCTCATGGTATATTTGCAGCCAGTACTCTATATGAACAATCCGTCTGGATCACGGATGTAGGAAGTGAGTATAACAAAGC
CATCCGGAACTACACCCGCTTCGATGACTGGTACCTGTGGGTTCAGATGTACAAGGGGACTGTGTCCATGCCAGTCTTCCAGTCCTTGGA
GGCCTACTGGCCTGGTCTTCAGAGCCTCATTGGAGACATTGACAATGCCATGAGGACCTTCCTCAACTACTACACTGTATGGAAGCAGTT
TGGGGGGCTCCCGGAATTCTACAACATTCCTCAGGGATACACAGTGGAGAAGCGAGAGGGCTACCCACTTCGGCCAGAACTTATTGAAAG
CGCAATGTACCTCTACCGTGCCACGGGGGATCCCACCCTCCTAGAACTCGGAAGAGATGCTGTGGAATCCATTGAAAAAATCAGCAAGGT
GGAGTGCGGATTTGCAACAATCAAAGATCTGCGAGACCACAAGCTGGACAACCGCATGGAGTCGTTCTTCCTGGCCGAGACTGTGAAATA
CCTCTACCTCCTGTTTGACCCAACCAACTTCATCCACAACAATGGGTCCACCTTCGACGCGGTGATCACCCCCTATGGGGAGTGCATCCT
GGGGGCTGGGGGGTACATCTTCAACACAGAAGCTCACCCCATCGACCCTGCCGCCCTGCACTGCTGCCAGAGGCTGAAGGAAGAGCAGTG
GGAGGTGGAGGACTTGATGAGGGAATTCTACTCTCTCAAACGGAGCAGGTCGAAATTTCAGAAAAACACTGTTAGTTCGGGGCCATGGGA
ACCTCCAGCAAGGCCAGGAACACTCTTCTCACCAGAAAACCATGACCAGGCAAGGGAGAGGAAGCCTGCCAAACAGAAGGTCCCACTTCT
CAGCTGCCCCAGTCAGCCCTTCACCTCCAAGTTGGCATTACTGGGACAGGTTTTCCTAGACTCCTCATAACCACTGGATAATTTTTTTAT

>59076_59076_7_NHLRC3-EDEM2_NHLRC3_chr13_39613848_ENST00000379600_EDEM2_chr20_33714178_ENST00000374492_length(amino acids)=484AA_BP=187
MVSVPFRTQSSCIQGGETGDRVFGPRADPLCRCKPLQPEAVRSSPRHLRTLPLLASRLVMARFWVCVAGAGFFLAFLVLHSRFCGSPVLR
NFTFAVSWRTEKILYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVFTEDGYFLRAWNYTVDTPHGIFAASTLYEQSV
WITDVGSEYNKAIRNYTRFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKR
EGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTF
DAVITPYGECILGAGGYIFNTEAHPIDPAALHCCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENHDQAR

--------------------------------------------------------------
>59076_59076_8_NHLRC3-EDEM2_NHLRC3_chr13_39613848_ENST00000379600_EDEM2_chr20_33714178_ENST00000540582_length(transcript)=1672nt_BP=707nt
GGTGGCCACTGAAAGTCAGCGGCGCGGACTGCCCTGAGGGCGGGAAAGGGTGGTCACTGGGTCAGCCCGAAGCACCTGACATGAGGGCGG
GGACCCCGAAATGCACACGAAGTCCGGAACTGGTCTTCTGTGATTTTCATTCGCCCTGGTCTCTGTTCCCTTTCGTACTCAAAGCTCGTG
CATCCAGGGAGGGGAAACCGGAGATAGGGTCTTCGGGCCCCGGGCAGACCCTCTGTGCCGCTGCAAACCGTTGCAGCCTGAGGCTGTCAG
GTCCTCCCCCAGACACCTGCGGACCCTCCCTCTCCTGGCTTCCCGTCTGGTCATGGCGAGATTCTGGGTCTGCGTAGCCGGTGCTGGCTT
CTTTCTTGCATTTTTGGTTTTGCATTCGCGTTTTTGTGGCTCTCCAGTTTTGAGGAACTTTACTTTTGCAGTTTCCTGGAGAACTGAGAA
AATTCTTTACCGGCTGGATGTGGGTTGGCCTAAGCACCCAGAATATTTTACCGGAACAACATTTTGTGTTGCAGTTGACTCCCTCAATGG
ATTGGTTTACATAGGTCAAAGAGGGGATAACATCCCAAAGATATTAGTGTTCACAGAGGATGGATATTTCCTACGAGCCTGGAATTATAC
AGTTGACACACCTCATGGTATATTTGCAGCCAGTACTCTATATGAACAATCCGTCTGGATCACGGATGTAGGAAGTGAGTATAACAAAGC
CATCCGGAACTACACCCGCTTCGATGACTGGTACCTGTGGGTTCAGATGTACAAGGGGACTGTGTCCATGCCAGTCTTCCAGTCCTTGGA
GGCCTACTGGCCTGGTCTTCAGAGCCTCATTGGAGACATTGACAATGCCATGAGGACCTTCCTCAACTACTACACTGTATGGAAGCAGTT
TGGGGGGCTCCCGGAATTCTACAACATTCCTCAGGGATACACAGTGGAGAAGCGAGAGGGCTACCCACTTCGGCCAGAACTTATTGAAAG
CGCAATGTACCTCTACCGTGCCACGGGGGATCCCACCCTCCTAGAACTCGGAAGAGATGCTGTGGAATCCATTGAAAAAATCAGCAAGGT
GGAGTGCGGATTTGCAACAGTAAGTGTTTGCATGGCCCCAAGAACTGGGAAGAGTCTCCCCTTGCTGCTAAAAAGCCTCTTTAAGGGTAG
AGCTTTGGGAGTTCTGACATATCAGCACTAGAAGGGACCTTGGAGATATACATAATGCTCATATTTTACAGATGGGGAGACCAAAGAACA
GAGAAGCTAAGTGCCTTGCTAAAGATCTCACAGCTAGTAGAGGTAGAGCTAGAATTAGTTCCTTGGGATCTTGACCCCGGCCCTTGGCAT
TCCTCCCACAGTGGAGATCTTTGATCTGTTTGAATAGGTGACTTTGAAAAGGTGAGTTTAGCGAAAAGTTTTGTGAGACACTAAAATAGA
TTTTAAGGGGAATCCAGAGTCCCATAGCCCTATATTCAAACCTGGGACTCCTTAACAAAGCAGTCCTGCTTAGTCTCACAGATATTTCTT
GAATGTCTTTCACATGCCAGGCACTCTGCTAGGCCCAAGGGTTACAGCAGTGGCCTTGCTCTCATGGAGCTTACATTTTAATGAGAAAAA

>59076_59076_8_NHLRC3-EDEM2_NHLRC3_chr13_39613848_ENST00000379600_EDEM2_chr20_33714178_ENST00000540582_length(amino acids)=351AA_BP=187
MVSVPFRTQSSCIQGGETGDRVFGPRADPLCRCKPLQPEAVRSSPRHLRTLPLLASRLVMARFWVCVAGAGFFLAFLVLHSRFCGSPVLR
NFTFAVSWRTEKILYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVFTEDGYFLRAWNYTVDTPHGIFAASTLYEQSV
WITDVGSEYNKAIRNYTRFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKR

--------------------------------------------------------------
>59076_59076_9_NHLRC3-EDEM2_NHLRC3_chr13_39613848_ENST00000379600_EDEM2_chr20_33714178_ENST00000541621_length(transcript)=1668nt_BP=707nt
GGTGGCCACTGAAAGTCAGCGGCGCGGACTGCCCTGAGGGCGGGAAAGGGTGGTCACTGGGTCAGCCCGAAGCACCTGACATGAGGGCGG
GGACCCCGAAATGCACACGAAGTCCGGAACTGGTCTTCTGTGATTTTCATTCGCCCTGGTCTCTGTTCCCTTTCGTACTCAAAGCTCGTG
CATCCAGGGAGGGGAAACCGGAGATAGGGTCTTCGGGCCCCGGGCAGACCCTCTGTGCCGCTGCAAACCGTTGCAGCCTGAGGCTGTCAG
GTCCTCCCCCAGACACCTGCGGACCCTCCCTCTCCTGGCTTCCCGTCTGGTCATGGCGAGATTCTGGGTCTGCGTAGCCGGTGCTGGCTT
CTTTCTTGCATTTTTGGTTTTGCATTCGCGTTTTTGTGGCTCTCCAGTTTTGAGGAACTTTACTTTTGCAGTTTCCTGGAGAACTGAGAA
AATTCTTTACCGGCTGGATGTGGGTTGGCCTAAGCACCCAGAATATTTTACCGGAACAACATTTTGTGTTGCAGTTGACTCCCTCAATGG
ATTGGTTTACATAGGTCAAAGAGGGGATAACATCCCAAAGATATTAGTGTTCACAGAGGATGGATATTTCCTACGAGCCTGGAATTATAC
AGTTGACACACCTCATGGTATATTTGCAGCCAGTACTCTATATGAACAATCCGTCTGGATCACGGATGTAGGAAGTGAGTATAACAAAGC
CATCCGGAACTACACCCGCTTCGATGACTGGTACCTGTGGGTTCAGATGTACAAGGGGACTGTGTCCATGCCAGTCTTCCAGTCCTTGGA
GGCCTACTGGCCTGGTCTTCAGAGCCTCATTGGAGACATTGACAATGCCATGAGGACCTTCCTCAACTACTACACTGTATGGAAGCAGTT
TGGGGGGCTCCCGGAATTCTACAACATTCCTCAGGGATACACAGTGGAGAAGCGAGAGGGCTACCCACTTCGGCCAGAACTTATTGAAAG
CGCAATGTACCTCTACCGTGCCACGGGGGATCCCACCCTCCTAGAACTCGGAAGAGATGCTGTGGAATCCATTGAAAAAATCAGCAAGGT
GGAGTGCGGATTTGCAACAATCAAAGATCTGCGAGACCACAAGCTGGACAACCGCATGGAGTCGTTCTTCCTGGCCGAGACTGTGAAATA
CCTCTACCTCCTGTTTGACCCAACCAACTTCATCCACAACAATGGGTCCACCTTCGACGCGGTGATCACCCCCTATGGGGAGTGCATCCT
GGGGGCTGGGGGGTACATCTTCAACACAGAAGCTCACCCCATCGACCCTGCCGCCCTGCACTGCTGCCAGAGGCTGAAGGAAGAGCAGTG
GGAGGTGGAGGACTTGATGAGGGAATTCTACTCTCTCAAACGGAGCAGGTCGAAATTTCAGAAAAACACTGTTAGTTCGGGGCCATGGGA
ACCTCCAGCAAGGCCAGGAACACTCTTCTCACCAGAAAACCATGACCAGGCAAGGGAGAGGAAGCCTGCCAAACAGAAGGTCCCACTTCT
CAGCTGCCCCAGTCAGCCCTTCACCTCCAAGTTGGCATTACTGGGACAGGTTTTCCTAGACTCCTCATAACCACTGGATAATTTTTTTAT

>59076_59076_9_NHLRC3-EDEM2_NHLRC3_chr13_39613848_ENST00000379600_EDEM2_chr20_33714178_ENST00000541621_length(amino acids)=484AA_BP=187
MVSVPFRTQSSCIQGGETGDRVFGPRADPLCRCKPLQPEAVRSSPRHLRTLPLLASRLVMARFWVCVAGAGFFLAFLVLHSRFCGSPVLR
NFTFAVSWRTEKILYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVFTEDGYFLRAWNYTVDTPHGIFAASTLYEQSV
WITDVGSEYNKAIRNYTRFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKR
EGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTF
DAVITPYGECILGAGGYIFNTEAHPIDPAALHCCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENHDQAR

--------------------------------------------------------------
>59076_59076_10_NHLRC3-EDEM2_NHLRC3_chr13_39613848_ENST00000379600_EDEM2_chr20_33714178_ENST00000542871_length(transcript)=1666nt_BP=707nt
GGTGGCCACTGAAAGTCAGCGGCGCGGACTGCCCTGAGGGCGGGAAAGGGTGGTCACTGGGTCAGCCCGAAGCACCTGACATGAGGGCGG
GGACCCCGAAATGCACACGAAGTCCGGAACTGGTCTTCTGTGATTTTCATTCGCCCTGGTCTCTGTTCCCTTTCGTACTCAAAGCTCGTG
CATCCAGGGAGGGGAAACCGGAGATAGGGTCTTCGGGCCCCGGGCAGACCCTCTGTGCCGCTGCAAACCGTTGCAGCCTGAGGCTGTCAG
GTCCTCCCCCAGACACCTGCGGACCCTCCCTCTCCTGGCTTCCCGTCTGGTCATGGCGAGATTCTGGGTCTGCGTAGCCGGTGCTGGCTT
CTTTCTTGCATTTTTGGTTTTGCATTCGCGTTTTTGTGGCTCTCCAGTTTTGAGGAACTTTACTTTTGCAGTTTCCTGGAGAACTGAGAA
AATTCTTTACCGGCTGGATGTGGGTTGGCCTAAGCACCCAGAATATTTTACCGGAACAACATTTTGTGTTGCAGTTGACTCCCTCAATGG
ATTGGTTTACATAGGTCAAAGAGGGGATAACATCCCAAAGATATTAGTGTTCACAGAGGATGGATATTTCCTACGAGCCTGGAATTATAC
AGTTGACACACCTCATGGTATATTTGCAGCCAGTACTCTATATGAACAATCCGTCTGGATCACGGATGTAGGAAGTGAGTATAACAAAGC
CATCCGGAACTACACCCGCTTCGATGACTGGTACCTGTGGGTTCAGATGTACAAGGGGACTGTGTCCATGCCAGTCTTCCAGTCCTTGGA
GGCCTACTGGCCTGGTCTTCAGAGCCTCATTGGAGACATTGACAATGCCATGAGGACCTTCCTCAACTACTACACTGTATGGAAGCAGTT
TGGGGGGCTCCCGGAATTCTACAACATTCCTCAGGGATACACAGTGGAGAAGCGAGAGGGCTACCCACTTCGGCCAGAACTTATTGAAAG
CGCAATGTACCTCTACCGTGCCACGGGGGATCCCACCCTCCTAGAACTCGGAAGAGATGCTGTGGAATCCATTGAAAAAATCAGCAAGGT
GGAGTGCGGATTTGCAACAATCAAAGATCTGCGAGACCACAAGCTGGACAACCGCATGGAGTCGTTCTTCCTGGCCGAGACTGTGAAATA
CCTCTACCTCCTGTTTGACCCAACCAACTTCATCCACAACAATGGGTCCACCTTCGACGCGGTGATCACCCCCTATGGGGAGTGCATCCT
GGGGGCTGGGGGGTACATCTTCAACACAGAAGCTCACCCCATCGACCCTGCCGCCCTGCACTGCTGCCAGAGGCTGAAGGAAGAGCAGTG
GGAGGTGGAGGACTTGATGAGGGAATTCTACTCTCTCAAACGGAGCAGGTCGAAATTTCAGAAAAACACTGTTAGTTCGGGGCCATGGGA
ACCTCCAGCAAGGCCAGGAACACTCTTCTCACCAGAAAACCATGACCAGGCAAGGGAGAGGAAGCCTGCCAAACAGAAGGTCCCACTTCT
CAGCTGCCCCAGTCAGCCCTTCACCTCCAAGTTGGCATTACTGGGACAGGTTTTCCTAGACTCCTCATAACCACTGGATAATTTTTTTAT

>59076_59076_10_NHLRC3-EDEM2_NHLRC3_chr13_39613848_ENST00000379600_EDEM2_chr20_33714178_ENST00000542871_length(amino acids)=484AA_BP=187
MVSVPFRTQSSCIQGGETGDRVFGPRADPLCRCKPLQPEAVRSSPRHLRTLPLLASRLVMARFWVCVAGAGFFLAFLVLHSRFCGSPVLR
NFTFAVSWRTEKILYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVFTEDGYFLRAWNYTVDTPHGIFAASTLYEQSV
WITDVGSEYNKAIRNYTRFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKR
EGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTF
DAVITPYGECILGAGGYIFNTEAHPIDPAALHCCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENHDQAR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NHLRC3-EDEM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NHLRC3-EDEM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NHLRC3-EDEM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource