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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NIN-NIN (FusionGDB2 ID:59160)

Fusion Gene Summary for NIN-NIN

check button Fusion gene summary
Fusion gene informationFusion gene name: NIN-NIN
Fusion gene ID: 59160
HgeneTgene
Gene symbol

NIN

NIN

Gene ID

51199

51199

Gene namenineinninein
SynonymsSCKL7SCKL7
Cytomap

14q22.1

14q22.1

Type of geneprotein-codingprotein-coding
Descriptionnineinglycogen synthase kinase 3 beta-interacting proteinhNineinninein (GSK3B interacting protein)ninein centrosomal proteinnineinglycogen synthase kinase 3 beta-interacting proteinhNineinninein (GSK3B interacting protein)ninein centrosomal protein
Modification date2020032820200328
UniProtAcc

Q8N4C6

Q9Y2I6

Ensembl transtripts involved in fusion geneENST00000245441, ENST00000324330, 
ENST00000382041, ENST00000382043, 
ENST00000389868, ENST00000453196, 
ENST00000486200, ENST00000530997, 
ENST00000245441, ENST00000389868, 
ENST00000324330, ENST00000382041, 
ENST00000382043, ENST00000453196, 
ENST00000486200, ENST00000530997, 
Fusion gene scores* DoF score16 X 18 X 9=25927 X 9 X 4=252
# samples 2010
** MAII scorelog2(20/2592*10)=-3.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/252*10)=-1.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NIN [Title/Abstract] AND NIN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNIN(51187241)-NIN(51187329), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NIN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NIN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABU609146NINchr14

51187241

+NINchr14

51187329

-


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Fusion Gene ORF analysis for NIN-NIN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000245441ENST00000245441NINchr14

51187241

+NINchr14

51187329

-
intron-3UTRENST00000245441ENST00000389868NINchr14

51187241

+NINchr14

51187329

-
intron-3UTRENST00000324330ENST00000245441NINchr14

51187241

+NINchr14

51187329

-
intron-3UTRENST00000324330ENST00000389868NINchr14

51187241

+NINchr14

51187329

-
intron-3UTRENST00000382041ENST00000245441NINchr14

51187241

+NINchr14

51187329

-
intron-3UTRENST00000382041ENST00000389868NINchr14

51187241

+NINchr14

51187329

-
intron-3UTRENST00000382043ENST00000245441NINchr14

51187241

+NINchr14

51187329

-
intron-3UTRENST00000382043ENST00000389868NINchr14

51187241

+NINchr14

51187329

-
intron-3UTRENST00000389868ENST00000245441NINchr14

51187241

+NINchr14

51187329

-
intron-3UTRENST00000389868ENST00000389868NINchr14

51187241

+NINchr14

51187329

-
intron-3UTRENST00000453196ENST00000245441NINchr14

51187241

+NINchr14

51187329

-
intron-3UTRENST00000453196ENST00000389868NINchr14

51187241

+NINchr14

51187329

-
intron-3UTRENST00000486200ENST00000245441NINchr14

51187241

+NINchr14

51187329

-
intron-3UTRENST00000486200ENST00000389868NINchr14

51187241

+NINchr14

51187329

-
intron-3UTRENST00000530997ENST00000245441NINchr14

51187241

+NINchr14

51187329

-
intron-3UTRENST00000530997ENST00000389868NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000245441ENST00000324330NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000245441ENST00000382041NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000245441ENST00000382043NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000245441ENST00000453196NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000245441ENST00000486200NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000245441ENST00000530997NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000324330ENST00000324330NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000324330ENST00000382041NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000324330ENST00000382043NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000324330ENST00000453196NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000324330ENST00000486200NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000324330ENST00000530997NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000382041ENST00000324330NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000382041ENST00000382041NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000382041ENST00000382043NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000382041ENST00000453196NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000382041ENST00000486200NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000382041ENST00000530997NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000382043ENST00000324330NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000382043ENST00000382041NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000382043ENST00000382043NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000382043ENST00000453196NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000382043ENST00000486200NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000382043ENST00000530997NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000389868ENST00000324330NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000389868ENST00000382041NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000389868ENST00000382043NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000389868ENST00000453196NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000389868ENST00000486200NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000389868ENST00000530997NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000453196ENST00000324330NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000453196ENST00000382041NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000453196ENST00000382043NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000453196ENST00000453196NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000453196ENST00000486200NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000453196ENST00000530997NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000486200ENST00000324330NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000486200ENST00000382041NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000486200ENST00000382043NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000486200ENST00000453196NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000486200ENST00000486200NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000486200ENST00000530997NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000530997ENST00000324330NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000530997ENST00000382041NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000530997ENST00000382043NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000530997ENST00000453196NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000530997ENST00000486200NINchr14

51187241

+NINchr14

51187329

-
intron-intronENST00000530997ENST00000530997NINchr14

51187241

+NINchr14

51187329

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NIN-NIN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NIN-NIN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:51187241/:51187329)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NIN

Q8N4C6

NIN

Q9Y2I6

FUNCTION: Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}.FUNCTION: Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis. {ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:16254247, ECO:0000269|PubMed:18538832}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NIN-NIN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NIN-NIN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NIN-NIN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NIN-NIN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource