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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NIPAL3-PPP4R1 (FusionGDB2 ID:59186)

Fusion Gene Summary for NIPAL3-PPP4R1

Fusion gene summary

Fusion gene information	Fusion gene name: NIPAL3-PPP4R1
	Fusion gene ID: 59186
		Hgene	Tgene
	Gene symbol	NIPAL3	PPP4R1
	Gene ID	57185	9989
	Gene name	NIPA like domain containing 3	protein phosphatase 4 regulatory subunit 1
	Synonyms	DJ462O23.2\|NPAL3	MEG1\|PP4(Rmeg)\|PP4R1
	Cytomap	1p36.11	18p11.22
	Type of gene	protein-coding	protein-coding
	Description	NIPA-like protein 3	serine/threonine-protein phosphatase 4 regulatory subunit 1serine/threonine phosphatase 4
	Modification date	20200313	20200313
	UniProtAcc	Q6P499	.
	Ensembl transtripts involved in fusion gene	ENST00000003912, ENST00000339255, ENST00000374399, ENST00000358028, ENST00000428131, ENST00000488155,	ENST00000580583, ENST00000400555, ENST00000400556,
Fusion gene scores	* DoF score	4 X 5 X 4=80	17 X 14 X 9=2142
	# samples	6	17
	** MAII score	log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(17/2142*10)=-3.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NIPAL3 [Title/Abstract] AND PPP4R1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NIPAL3(24790610)-PPP4R1(9547950), # samples:1
Anticipated loss of major functional domain due to fusion event.	NIPAL3-PPP4R1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. NIPAL3-PPP4R1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across NIPAL3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PPP4R1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-XF-AAMY-01A	NIPAL3	chr1	24790610	-	PPP4R1	chr18	9547950	-

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Fusion Gene ORF analysis for NIPAL3-PPP4R1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000003912	ENST00000580583	NIPAL3	chr1	24790610	-	PPP4R1	chr18	9547950	-
5CDS-intron	ENST00000339255	ENST00000580583	NIPAL3	chr1	24790610	-	PPP4R1	chr18	9547950	-
5CDS-intron	ENST00000374399	ENST00000580583	NIPAL3	chr1	24790610	-	PPP4R1	chr18	9547950	-
Frame-shift	ENST00000003912	ENST00000400555	NIPAL3	chr1	24790610	-	PPP4R1	chr18	9547950	-
Frame-shift	ENST00000339255	ENST00000400555	NIPAL3	chr1	24790610	-	PPP4R1	chr18	9547950	-
Frame-shift	ENST00000374399	ENST00000400555	NIPAL3	chr1	24790610	-	PPP4R1	chr18	9547950	-
In-frame	ENST00000003912	ENST00000400556	NIPAL3	chr1	24790610	-	PPP4R1	chr18	9547950	-
In-frame	ENST00000339255	ENST00000400556	NIPAL3	chr1	24790610	-	PPP4R1	chr18	9547950	-
In-frame	ENST00000374399	ENST00000400556	NIPAL3	chr1	24790610	-	PPP4R1	chr18	9547950	-
intron-3CDS	ENST00000358028	ENST00000400555	NIPAL3	chr1	24790610	-	PPP4R1	chr18	9547950	-
intron-3CDS	ENST00000358028	ENST00000400556	NIPAL3	chr1	24790610	-	PPP4R1	chr18	9547950	-
intron-3CDS	ENST00000428131	ENST00000400555	NIPAL3	chr1	24790610	-	PPP4R1	chr18	9547950	-
intron-3CDS	ENST00000428131	ENST00000400556	NIPAL3	chr1	24790610	-	PPP4R1	chr18	9547950	-
intron-3CDS	ENST00000488155	ENST00000400555	NIPAL3	chr1	24790610	-	PPP4R1	chr18	9547950	-
intron-3CDS	ENST00000488155	ENST00000400556	NIPAL3	chr1	24790610	-	PPP4R1	chr18	9547950	-
intron-intron	ENST00000358028	ENST00000580583	NIPAL3	chr1	24790610	-	PPP4R1	chr18	9547950	-
intron-intron	ENST00000428131	ENST00000580583	NIPAL3	chr1	24790610	-	PPP4R1	chr18	9547950	-
intron-intron	ENST00000488155	ENST00000580583	NIPAL3	chr1	24790610	-	PPP4R1	chr18	9547950	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000374399	NIPAL3	chr1	24790610	-	ENST00000400556	PPP4R1	chr18	9547950	-	2551	1389	368	1552	394
ENST00000003912	NIPAL3	chr1	24790610	-	ENST00000400556	PPP4R1	chr18	9547950	-	2652	1490	568	1653	361
ENST00000339255	NIPAL3	chr1	24790610	-	ENST00000400556	PPP4R1	chr18	9547950	-	2531	1369	348	1532	394

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000374399	ENST00000400556	NIPAL3	chr1	24790610	-	PPP4R1	chr18	9547950	-	0.004747412	0.9952526
ENST00000003912	ENST00000400556	NIPAL3	chr1	24790610	-	PPP4R1	chr18	9547950	-	0.001702454	0.9982975
ENST00000339255	ENST00000400556	NIPAL3	chr1	24790610	-	PPP4R1	chr18	9547950	-	0.004616127	0.9953839

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Fusion Genomic Features for NIPAL3-PPP4R1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NIPAL3-PPP4R1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:24790610/chr18:9547950)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NIPAL3 Q6P499	.
	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000003912

18_21

258

325.0

Compositional bias

Note=Poly-Ser

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000374399

18_21

340

407.0

Compositional bias

Note=Poly-Ser

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000003912

101_121

258

325.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000003912

135_155

258

325.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000003912

171_191

258

325.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000003912

202_222

258

325.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000003912

240_260

258

325.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000003912

33_53

258

325.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000003912

76_96

258

325.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000374399

101_121

340

407.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000374399

135_155

340

407.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000374399

171_191

340

407.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000374399

202_222

340

407.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000374399

240_260

340

407.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000374399

271_291

340

407.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000374399

300_320

340

407.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000374399

33_53

340

407.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000374399

76_96

340

407.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000358028

18_21

227.0

Compositional bias

Note=Poly-Ser

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000428131

18_21

227.0

Compositional bias

Note=Poly-Ser

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000003912

271_291

258

325.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000003912

300_320

258

325.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000358028

101_121

227.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000358028

135_155

227.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000358028

171_191

227.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000358028

202_222

227.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000358028

240_260

227.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000358028

271_291

227.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000358028

300_320

227.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000358028

33_53

227.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000358028

76_96

227.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000428131

101_121

227.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000428131

135_155

227.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000428131

171_191

227.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000428131

202_222

227.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000428131

240_260

227.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000428131

271_291

227.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000428131

300_320

227.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000428131

33_53

227.0

Transmembrane

Helical

Hgene

NIPAL3

chr1:24790610

chr18:9547950

ENST00000428131

76_96

227.0

Transmembrane

Helical

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400555

127_164

879

934.0

Repeat

Note=HEAT 5

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400555

168_206

879

934.0

Repeat

Note=HEAT 6

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400555

1_25

879

934.0

Repeat

Note=HEAT 1

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400555

208_246

879

934.0

Repeat

Note=HEAT 7

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400555

248_285

879

934.0

Repeat

Note=HEAT 8

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400555

26_63

879

934.0

Repeat

Note=HEAT 2

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400555

287_324

879

934.0

Repeat

Note=HEAT 9

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400555

505_542

879

934.0

Repeat

Note=HEAT 10

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400555

568_606

879

934.0

Repeat

Note=HEAT 11

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400555

65_81

879

934.0

Repeat

Note=HEAT 3

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400555

698_734

879

934.0

Repeat

Note=HEAT 12

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400555

799_837

879

934.0

Repeat

Note=HEAT 13

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400555

82_119

879

934.0

Repeat

Note=HEAT 4

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400555

861_898

879

934.0

Repeat

Note=HEAT 14

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400556

127_164

896

951.0

Repeat

Note=HEAT 5

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400556

168_206

896

951.0

Repeat

Note=HEAT 6

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400556

1_25

896

951.0

Repeat

Note=HEAT 1

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400556

208_246

896

951.0

Repeat

Note=HEAT 7

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400556

248_285

896

951.0

Repeat

Note=HEAT 8

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400556

26_63

896

951.0

Repeat

Note=HEAT 2

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400556

287_324

896

951.0

Repeat

Note=HEAT 9

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400556

505_542

896

951.0

Repeat

Note=HEAT 10

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400556

568_606

896

951.0

Repeat

Note=HEAT 11

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400556

65_81

896

951.0

Repeat

Note=HEAT 3

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400556

698_734

896

951.0

Repeat

Note=HEAT 12

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400556

799_837

896

951.0

Repeat

Note=HEAT 13

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400556

82_119

896

951.0

Repeat

Note=HEAT 4

Tgene

PPP4R1

chr1:24790610

chr18:9547950

ENST00000400556

861_898

896

951.0

Repeat

Note=HEAT 14

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Fusion Gene Sequence for NIPAL3-PPP4R1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>59186_59186_1_NIPAL3-PPP4R1_NIPAL3_chr1_24790610_ENST00000003912_PPP4R1_chr18_9547950_ENST00000400556_length(transcript)=2652nt_BP=1490nt
AATTGGGAAGGGATGAAGGAGGCTGTGCCTCCGGGTTGCACGAAGAGTCCGAGTCATTTCTCAGAAGGTTTTGATAGGTGGGCCTTAGAG
GAGACGCCGCCGAGCACCGCAAGAACTGGAAAACACACCCCTCTCTGTCTGCCTGGGAGAGCCACGGAAATTGGCACTTCTCTGAGTGAA
GCTGAGGAGAAGGCTGTAAATCTGCCAAAACAGCCTTGAAGTATTCTTTTGTCATGAGGAAGTGACGGCTGCTGGAGGGAGGTGAACACC
ACAAGGAGAGATGGCATCTGGCCTGGGCCCCGCCTAGCAGCAGCTCCACCTCCTAGGCCAGGCCCTGTGGGATGCGCCACTAGACCACCA
TGGACGGATCCCACAGCGCAGCCCTGAAGCTGCAGCAGCTGCCTCCCACAAGTAGCTCCAGCGCCGTAAGCGAGGCCTCCTTCTCCTACA
AGCTGCCCTGAGGAGTAAGTACCGTTAATAACTCCATTTTACAGTTGAGGAAACAAATGCCCAAAGATATGTCCGAGTCACAGTGTCATG
AAGGACAGAGGCTGGATTCAAGGAAAACCTGATTGGCGCCCTCTTGGCGATCTTCGGGCACCTCGTGGTCAGCATTGCACTTAACCTCCA
GAAGTACTGCCACATCCGCCTGGCAGGCTCCAAGGATCCCCGGGCCTATTTCAAGACCAAGACATGGTGGCTGGGCCTGTTCCTGATGCT
TCTGGGCGAGCTGGGTGTGTTCGCCTCCTACGCCTTCGCGCCGCTGTCACTCATCGTGCCCCTCAGCGCAGTTTCTGTGATAGCTAGTGC
CATCATAGGAATCATATTCATCAAGGAAAAGTGGAAACCGAAAGACTTTCTGAGGCGCTACGTCTTGTCCTTTGTTGGCTGCGGTTTGGC
TGTCGTGGGTACCTACCTGCTGGTGACATTCGCACCCAACAGTCACGAGAAGATGACAGGCGAGAATGTCACCAGGCACCTCGTGAGCTG
GCCTTTCCTTTTGTACATGCTGGTGGAGATCATTCTGTTCTGCTTGCTGCTCTACTTCTACAAGGAGAAGAACGCCAACAACATTGTCGT
GATTCTTCTCTTGGTGGCGTTACTTGGCTCCATGACAGTGGTGACAGTCAAGGCCGTGGCTGGGATGCTTGTCTTGTCCATTCAAGGGAA
CCTGCAGCTTGACTACCCCATCTTCTACGTGATGTTCGTGTGCATGGTGGCAACCGCCGTCTATCAGGCTGCGTTTTTGAGTCAAGCCTC
ACAGATGTACGACTCCTCTTTGATTGCCAGTGTGGGCTACATTCTGTCCACAACCATTGCTATCACAGCAGGTGCAATATTTTACCTGGA
CTTCATCGGGGAGGACGTGCTGCACATCTGCATGTTTGCACTGGGGTGCCTCATTGCATTCTTGGGCGTCTTCTTAATCACGCGTAACAG
GAAGAAGCCCATTCCATTTGAGCCCTATATTTCCATGGATGCCATGCCAGACTATTTCTTGGCCTCTGCCAGCTGCCACCAGGAGGCTGT
GGAGCAGACCATCATGGCTCTTCAGATGGACCGTGACAGCGATGTCAAGTATTTTGCAAGCATCCACCCTGCCAGTACCAAAATCTCCGA
AGATGCCATGAGCACAGCGTCCTCAACCTACTAGAAGGCTTGAATCTCGGTGTCTTTCCTGCTTCCATGAGAGCCGAGGTTCAGTGGGCA
TTCGCCACGCATGTGACCTGGGATAGCTTTCGGGGGAGGAGAGACCTTCCTCTCCTGCGGACTTCATTGCAGGTGCAAGTTGCCTACACC
CAATACCAGGGATTTCAAGAGTCAAGAGAAAGTACAGTAAACACTATTATCTTATCTTGACTTTAAGGGGAAATAATTTCTCAGAGGATT
ATAATTGTCACCGAAGCCTTAAATCCTTCTGTCTTCCTGACTGAATGAAACTTGAATTGGCAGAGCATTTTCCTTATGGAAGGGATGAGA
TTCCCAGAGACCTGCATTGCTTTCTCCTGGTTTTATTTAACAATCGACAAATGAAATTCTTACAGCCTGAAGGCAGACGTGTGCCCAGAT
GTGAAAGAGACCTTCAGTATCAGCCCTAACTCTTCTCTCCCAGGAAGGACTTGCTGGGCTCTGTGGCCAGCTGTCCAGCCCAGCCCTGTG
TGTGAATCGTTTGTGACGTGTGCAAATGGGAAAGGAGGGGTTTTTACATCTCCTAAAGGACCTGATGCCAACACAAGTAGGATTGACTTA
AACTCTTAAGCGCAGCATATTGCTGTACACATTTACAGAATGGTTGCTGAGTGTCTGTGTCTGATTTTTTCATGCTGGTCATGACCTGAA
GGAAATTTATTAGACGTATAATGTATGTCTGGTGTTTTTAACTTGATCATGATCAGCTCTGAGGTGCAACTTCTTCACATACTGTACATA
CCTGTGACCACTCTTGGGAGTGCTGCAGTCTTTAATCATGCTGTTTAAACTGTTGTGGCACAAGTTCTCTTGTCCAAATAAAATTTATTA
ATAAGATCTATAGAGAGAGATATATACACTTTTGATTGTTTTCTAGATGTCTACCAATAAATGCAATTTGTGACCTGTATTAATGATTTA

>59186_59186_1_NIPAL3-PPP4R1_NIPAL3_chr1_24790610_ENST00000003912_PPP4R1_chr18_9547950_ENST00000400556_length(amino acids)=361AA_BP=306
MIGALLAIFGHLVVSIALNLQKYCHIRLAGSKDPRAYFKTKTWWLGLFLMLLGELGVFASYAFAPLSLIVPLSAVSVIASAIIGIIFIKE
KWKPKDFLRRYVLSFVGCGLAVVGTYLLVTFAPNSHEKMTGENVTRHLVSWPFLLYMLVEIILFCLLLYFYKEKNANNIVVILLLVALLG
SMTVVTVKAVAGMLVLSIQGNLQLDYPIFYVMFVCMVATAVYQAAFLSQASQMYDSSLIASVGYILSTTIAITAGAIFYLDFIGEDVLHI
CMFALGCLIAFLGVFLITRNRKKPIPFEPYISMDAMPDYFLASASCHQEAVEQTIMALQMDRDSDVKYFASIHPASTKISEDAMSTASST

--------------------------------------------------------------
>59186_59186_2_NIPAL3-PPP4R1_NIPAL3_chr1_24790610_ENST00000339255_PPP4R1_chr18_9547950_ENST00000400556_length(transcript)=2531nt_BP=1369nt
GATGAAGGAGGCTGTGCCTCCGGGTTGCACGAAGAGTCCGAGTCATTTCTCAGAAGGTTTTGATAGGTGGGCCTTAGAGGAGACGCCGCC
GAGCACCGCAAGAACTGGAAAACACACCCCTCTCTGTCTGCCTGGGAGAGCCACGGAAATTGGCACTTCTCTGAGTGAAGCTGAGGAGAA
GGCTGTAAATCTGCCAAAACAGCCTTGAAGTATTCTTTTGTCATGAGGAAGTGACGGCTGCTGGAGGGAGGTGAACACCACAAGGAGAGA
TGGCATCTGGCCTGGGCCCCGCCTAGCAGCAGCTCCACCTCCTAGGCCAGGCCCTGTGGGATGCGCCACTAGACCACCATGGACGGATCC
CACAGCGCAGCCCTGAAGCTGCAGCAGCTGCCTCCCACAAGTAGCTCCAGCGCCGTAAGCGAGGCCTCCTTCTCCTACAAGGAAAACCTG
ATTGGCGCCCTCTTGGCGATCTTCGGGCACCTCGTGGTCAGCATTGCACTTAACCTCCAGAAGTACTGCCACATCCGCCTGGCAGGCTCC
AAGGATCCCCGGGCCTATTTCAAGACCAAGACATGGTGGCTGGGCCTGTTCCTGATGCTTCTGGGCGAGCTGGGTGTGTTCGCCTCCTAC
GCCTTCGCGCCGCTGTCACTCATCGTGCCCCTCAGCGCAGTTTCTGTGATAGCTAGTGCCATCATAGGAATCATATTCATCAAGGAAAAG
TGGAAACCGAAAGACTTTCTGAGGCGCTACGTCTTGTCCTTTGTTGGCTGCGGTTTGGCTGTCGTGGGTACCTACCTGCTGGTGACATTC
GCACCCAACAGTCACGAGAAGATGACAGGCGAGAATGTCACCAGGCACCTCGTGAGCTGGCCTTTCCTTTTGTACATGCTGGTGGAGATC
ATTCTGTTCTGCTTGCTGCTCTACTTCTACAAGGAGAAGAACGCCAACAACATTGTCGTGATTCTTCTCTTGGTGGCGTTACTTGGCTCC
ATGACAGTGGTGACAGTCAAGGCCGTGGCTGGGATGCTTGTCTTGTCCATTCAAGGGAACCTGCAGCTTGACTACCCCATCTTCTACGTG
ATGTTCGTGTGCATGGTGGCAACCGCCGTCTATCAGGCTGCGTTTTTGAGTCAAGCCTCACAGATGTACGACTCCTCTTTGATTGCCAGT
GTGGGCTACATTCTGTCCACAACCATTGCTATCACAGCAGGTGCAATATTTTACCTGGACTTCATCGGGGAGGACGTGCTGCACATCTGC
ATGTTTGCACTGGGGTGCCTCATTGCATTCTTGGGCGTCTTCTTAATCACGCGTAACAGGAAGAAGCCCATTCCATTTGAGCCCTATATT
TCCATGGATGCCATGCCAGACTATTTCTTGGCCTCTGCCAGCTGCCACCAGGAGGCTGTGGAGCAGACCATCATGGCTCTTCAGATGGAC
CGTGACAGCGATGTCAAGTATTTTGCAAGCATCCACCCTGCCAGTACCAAAATCTCCGAAGATGCCATGAGCACAGCGTCCTCAACCTAC
TAGAAGGCTTGAATCTCGGTGTCTTTCCTGCTTCCATGAGAGCCGAGGTTCAGTGGGCATTCGCCACGCATGTGACCTGGGATAGCTTTC
GGGGGAGGAGAGACCTTCCTCTCCTGCGGACTTCATTGCAGGTGCAAGTTGCCTACACCCAATACCAGGGATTTCAAGAGTCAAGAGAAA
GTACAGTAAACACTATTATCTTATCTTGACTTTAAGGGGAAATAATTTCTCAGAGGATTATAATTGTCACCGAAGCCTTAAATCCTTCTG
TCTTCCTGACTGAATGAAACTTGAATTGGCAGAGCATTTTCCTTATGGAAGGGATGAGATTCCCAGAGACCTGCATTGCTTTCTCCTGGT
TTTATTTAACAATCGACAAATGAAATTCTTACAGCCTGAAGGCAGACGTGTGCCCAGATGTGAAAGAGACCTTCAGTATCAGCCCTAACT
CTTCTCTCCCAGGAAGGACTTGCTGGGCTCTGTGGCCAGCTGTCCAGCCCAGCCCTGTGTGTGAATCGTTTGTGACGTGTGCAAATGGGA
AAGGAGGGGTTTTTACATCTCCTAAAGGACCTGATGCCAACACAAGTAGGATTGACTTAAACTCTTAAGCGCAGCATATTGCTGTACACA
TTTACAGAATGGTTGCTGAGTGTCTGTGTCTGATTTTTTCATGCTGGTCATGACCTGAAGGAAATTTATTAGACGTATAATGTATGTCTG
GTGTTTTTAACTTGATCATGATCAGCTCTGAGGTGCAACTTCTTCACATACTGTACATACCTGTGACCACTCTTGGGAGTGCTGCAGTCT
TTAATCATGCTGTTTAAACTGTTGTGGCACAAGTTCTCTTGTCCAAATAAAATTTATTAATAAGATCTATAGAGAGAGATATATACACTT
TTGATTGTTTTCTAGATGTCTACCAATAAATGCAATTTGTGACCTGTATTAATGATTTAAAGTGGGGAAACTAGATTAAAATATTTGTCT

>59186_59186_2_NIPAL3-PPP4R1_NIPAL3_chr1_24790610_ENST00000339255_PPP4R1_chr18_9547950_ENST00000400556_length(amino acids)=394AA_BP=339
MDGSHSAALKLQQLPPTSSSSAVSEASFSYKENLIGALLAIFGHLVVSIALNLQKYCHIRLAGSKDPRAYFKTKTWWLGLFLMLLGELGV
FASYAFAPLSLIVPLSAVSVIASAIIGIIFIKEKWKPKDFLRRYVLSFVGCGLAVVGTYLLVTFAPNSHEKMTGENVTRHLVSWPFLLYM
LVEIILFCLLLYFYKEKNANNIVVILLLVALLGSMTVVTVKAVAGMLVLSIQGNLQLDYPIFYVMFVCMVATAVYQAAFLSQASQMYDSS
LIASVGYILSTTIAITAGAIFYLDFIGEDVLHICMFALGCLIAFLGVFLITRNRKKPIPFEPYISMDAMPDYFLASASCHQEAVEQTIMA

--------------------------------------------------------------
>59186_59186_3_NIPAL3-PPP4R1_NIPAL3_chr1_24790610_ENST00000374399_PPP4R1_chr18_9547950_ENST00000400556_length(transcript)=2551nt_BP=1389nt
GCAGCTCTGAATTGGGAAGGGATGAAGGAGGCTGTGCCTCCGGGTTGCACGAAGAGTCCGAGTCATTTCTCAGAAGGTTTTGATAGGTGG
GCCTTAGAGGAGACGCCGCCGAGCACCGCAAGAACTGGAAAACACACCCCTCTCTGTCTGCCTGGGAGAGCCACGGAAATTGGCACTTCT
CTGAGTGAAGCTGAGGAGAAGGCTGTAAATCTGCCAAAACAGCCTTGAAGTATTCTTTTGTCATGAGGAAGTGACGGCTGCTGGAGGGAG
GTGAACACCACAAGGAGAGATGGCATCTGGCCTGGGCCCCGCCTAGCAGCAGCTCCACCTCCTAGGCCAGGCCCTGTGGGATGCGCCACT
AGACCACCATGGACGGATCCCACAGCGCAGCCCTGAAGCTGCAGCAGCTGCCTCCCACAAGTAGCTCCAGCGCCGTAAGCGAGGCCTCCT
TCTCCTACAAGGAAAACCTGATTGGCGCCCTCTTGGCGATCTTCGGGCACCTCGTGGTCAGCATTGCACTTAACCTCCAGAAGTACTGCC
ACATCCGCCTGGCAGGCTCCAAGGATCCCCGGGCCTATTTCAAGACCAAGACATGGTGGCTGGGCCTGTTCCTGATGCTTCTGGGCGAGC
TGGGTGTGTTCGCCTCCTACGCCTTCGCGCCGCTGTCACTCATCGTGCCCCTCAGCGCAGTTTCTGTGATAGCTAGTGCCATCATAGGAA
TCATATTCATCAAGGAAAAGTGGAAACCGAAAGACTTTCTGAGGCGCTACGTCTTGTCCTTTGTTGGCTGCGGTTTGGCTGTCGTGGGTA
CCTACCTGCTGGTGACATTCGCACCCAACAGTCACGAGAAGATGACAGGCGAGAATGTCACCAGGCACCTCGTGAGCTGGCCTTTCCTTT
TGTACATGCTGGTGGAGATCATTCTGTTCTGCTTGCTGCTCTACTTCTACAAGGAGAAGAACGCCAACAACATTGTCGTGATTCTTCTCT
TGGTGGCGTTACTTGGCTCCATGACAGTGGTGACAGTCAAGGCCGTGGCTGGGATGCTTGTCTTGTCCATTCAAGGGAACCTGCAGCTTG
ACTACCCCATCTTCTACGTGATGTTCGTGTGCATGGTGGCAACCGCCGTCTATCAGGCTGCGTTTTTGAGTCAAGCCTCACAGATGTACG
ACTCCTCTTTGATTGCCAGTGTGGGCTACATTCTGTCCACAACCATTGCTATCACAGCAGGTGCAATATTTTACCTGGACTTCATCGGGG
AGGACGTGCTGCACATCTGCATGTTTGCACTGGGGTGCCTCATTGCATTCTTGGGCGTCTTCTTAATCACGCGTAACAGGAAGAAGCCCA
TTCCATTTGAGCCCTATATTTCCATGGATGCCATGCCAGACTATTTCTTGGCCTCTGCCAGCTGCCACCAGGAGGCTGTGGAGCAGACCA
TCATGGCTCTTCAGATGGACCGTGACAGCGATGTCAAGTATTTTGCAAGCATCCACCCTGCCAGTACCAAAATCTCCGAAGATGCCATGA
GCACAGCGTCCTCAACCTACTAGAAGGCTTGAATCTCGGTGTCTTTCCTGCTTCCATGAGAGCCGAGGTTCAGTGGGCATTCGCCACGCA
TGTGACCTGGGATAGCTTTCGGGGGAGGAGAGACCTTCCTCTCCTGCGGACTTCATTGCAGGTGCAAGTTGCCTACACCCAATACCAGGG
ATTTCAAGAGTCAAGAGAAAGTACAGTAAACACTATTATCTTATCTTGACTTTAAGGGGAAATAATTTCTCAGAGGATTATAATTGTCAC
CGAAGCCTTAAATCCTTCTGTCTTCCTGACTGAATGAAACTTGAATTGGCAGAGCATTTTCCTTATGGAAGGGATGAGATTCCCAGAGAC
CTGCATTGCTTTCTCCTGGTTTTATTTAACAATCGACAAATGAAATTCTTACAGCCTGAAGGCAGACGTGTGCCCAGATGTGAAAGAGAC
CTTCAGTATCAGCCCTAACTCTTCTCTCCCAGGAAGGACTTGCTGGGCTCTGTGGCCAGCTGTCCAGCCCAGCCCTGTGTGTGAATCGTT
TGTGACGTGTGCAAATGGGAAAGGAGGGGTTTTTACATCTCCTAAAGGACCTGATGCCAACACAAGTAGGATTGACTTAAACTCTTAAGC
GCAGCATATTGCTGTACACATTTACAGAATGGTTGCTGAGTGTCTGTGTCTGATTTTTTCATGCTGGTCATGACCTGAAGGAAATTTATT
AGACGTATAATGTATGTCTGGTGTTTTTAACTTGATCATGATCAGCTCTGAGGTGCAACTTCTTCACATACTGTACATACCTGTGACCAC
TCTTGGGAGTGCTGCAGTCTTTAATCATGCTGTTTAAACTGTTGTGGCACAAGTTCTCTTGTCCAAATAAAATTTATTAATAAGATCTAT
AGAGAGAGATATATACACTTTTGATTGTTTTCTAGATGTCTACCAATAAATGCAATTTGTGACCTGTATTAATGATTTAAAGTGGGGAAA

>59186_59186_3_NIPAL3-PPP4R1_NIPAL3_chr1_24790610_ENST00000374399_PPP4R1_chr18_9547950_ENST00000400556_length(amino acids)=394AA_BP=339
MDGSHSAALKLQQLPPTSSSSAVSEASFSYKENLIGALLAIFGHLVVSIALNLQKYCHIRLAGSKDPRAYFKTKTWWLGLFLMLLGELGV
FASYAFAPLSLIVPLSAVSVIASAIIGIIFIKEKWKPKDFLRRYVLSFVGCGLAVVGTYLLVTFAPNSHEKMTGENVTRHLVSWPFLLYM
LVEIILFCLLLYFYKEKNANNIVVILLLVALLGSMTVVTVKAVAGMLVLSIQGNLQLDYPIFYVMFVCMVATAVYQAAFLSQASQMYDSS
LIASVGYILSTTIAITAGAIFYLDFIGEDVLHICMFALGCLIAFLGVFLITRNRKKPIPFEPYISMDAMPDYFLASASCHQEAVEQTIMA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NIPAL3-PPP4R1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for NIPAL3-PPP4R1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for NIPAL3-PPP4R1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source