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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NIPBL-ARNTL2 (FusionGDB2 ID:59189)

Fusion Gene Summary for NIPBL-ARNTL2

check button Fusion gene summary
Fusion gene informationFusion gene name: NIPBL-ARNTL2
Fusion gene ID: 59189
HgeneTgene
Gene symbol

NIPBL

ARNTL2

Gene ID

25836

56938

Gene nameNIPBL cohesin loading factoraryl hydrocarbon receptor nuclear translocator like 2
SynonymsCDLS|CDLS1|IDN3|IDN3-B|Scc2BMAL2|CLIF|MOP9|PASD9|bHLHe6
Cytomap

5p13.2

12p11.23

Type of geneprotein-codingprotein-coding
Descriptionnipped-B-like proteinNipped-B homologSCC2 homologdelanginsister chromatid cohesion 2 homologaryl hydrocarbon receptor nuclear translocator-like protein 2CYCLE-like factorPAS domain-containing protein 9basic-helix-loop-helix-PAS protein MOP9brain and muscle ARNT-like 2class E basic helix-loop-helix protein 6member of PAS protein 9transcrip
Modification date2020031320200313
UniProtAcc

Q6KC79

Q8WYA1

Ensembl transtripts involved in fusion geneENST00000504430, ENST00000282516, 
ENST00000448238, 		ENST00000261178, 
ENST00000266503, ENST00000311001, 
ENST00000395901, ENST00000544915, 
ENST00000546179, ENST00000539558, 
ENST00000542388, 
Fusion gene scores* DoF score26 X 13 X 16=54086 X 5 X 5=150
# samples 437
** MAII scorelog2(43/5408*10)=-3.65268658669272
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NIPBL [Title/Abstract] AND ARNTL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNIPBL(36972143)-ARNTL2(27521195), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNIPBL

GO:0000122

negative regulation of transcription by RNA polymerase II

18854353

HgeneNIPBL

GO:0031065

positive regulation of histone deacetylation

18854353

HgeneNIPBL

GO:0045892

negative regulation of transcription, DNA-templated

18854353

HgeneNIPBL

GO:0071921

cohesin loading

22628566

TgeneARNTL2

GO:0006357

regulation of transcription by RNA polymerase II

12055078

TgeneARNTL2

GO:0007623

circadian rhythm

10864977

TgeneARNTL2

GO:0045893

positive regulation of transcription, DNA-templated

12738229

TgeneARNTL2

GO:0045944

positive regulation of transcription by RNA polymerase II

15147242


check buttonFusion gene breakpoints across NIPBL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARNTL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4READTCGA-AG-3731-01ANIPBLchr5

36972143

-ARNTL2chr12

27521195

+
ChimerDB4READTCGA-AG-3731-01ANIPBLchr5

36972143

+ARNTL2chr12

27521195

+


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Fusion Gene ORF analysis for NIPBL-ARNTL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000504430ENST00000261178NIPBLchr5

36972143

+ARNTL2chr12

27521195

+
3UTR-3CDSENST00000504430ENST00000266503NIPBLchr5

36972143

+ARNTL2chr12

27521195

+
3UTR-3CDSENST00000504430ENST00000311001NIPBLchr5

36972143

+ARNTL2chr12

27521195

+
3UTR-3CDSENST00000504430ENST00000395901NIPBLchr5

36972143

+ARNTL2chr12

27521195

+
3UTR-3CDSENST00000504430ENST00000544915NIPBLchr5

36972143

+ARNTL2chr12

27521195

+
3UTR-3CDSENST00000504430ENST00000546179NIPBLchr5

36972143

+ARNTL2chr12

27521195

+
3UTR-intronENST00000504430ENST00000539558NIPBLchr5

36972143

+ARNTL2chr12

27521195

+
3UTR-intronENST00000504430ENST00000542388NIPBLchr5

36972143

+ARNTL2chr12

27521195

+
5CDS-intronENST00000282516ENST00000539558NIPBLchr5

36972143

+ARNTL2chr12

27521195

+
5CDS-intronENST00000282516ENST00000542388NIPBLchr5

36972143

+ARNTL2chr12

27521195

+
5CDS-intronENST00000448238ENST00000539558NIPBLchr5

36972143

+ARNTL2chr12

27521195

+
5CDS-intronENST00000448238ENST00000542388NIPBLchr5

36972143

+ARNTL2chr12

27521195

+
In-frameENST00000282516ENST00000261178NIPBLchr5

36972143

+ARNTL2chr12

27521195

+
In-frameENST00000282516ENST00000266503NIPBLchr5

36972143

+ARNTL2chr12

27521195

+
In-frameENST00000282516ENST00000311001NIPBLchr5

36972143

+ARNTL2chr12

27521195

+
In-frameENST00000282516ENST00000395901NIPBLchr5

36972143

+ARNTL2chr12

27521195

+
In-frameENST00000282516ENST00000544915NIPBLchr5

36972143

+ARNTL2chr12

27521195

+
In-frameENST00000282516ENST00000546179NIPBLchr5

36972143

+ARNTL2chr12

27521195

+
In-frameENST00000448238ENST00000261178NIPBLchr5

36972143

+ARNTL2chr12

27521195

+
In-frameENST00000448238ENST00000266503NIPBLchr5

36972143

+ARNTL2chr12

27521195

+
In-frameENST00000448238ENST00000311001NIPBLchr5

36972143

+ARNTL2chr12

27521195

+
In-frameENST00000448238ENST00000395901NIPBLchr5

36972143

+ARNTL2chr12

27521195

+
In-frameENST00000448238ENST00000544915NIPBLchr5

36972143

+ARNTL2chr12

27521195

+
In-frameENST00000448238ENST00000546179NIPBLchr5

36972143

+ARNTL2chr12

27521195

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000282516NIPBLchr536972143+ENST00000544915ARNTL2chr1227521195+592113674993144881
ENST00000282516NIPBLchr536972143+ENST00000395901ARNTL2chr1227521195+310413674993102868
ENST00000282516NIPBLchr536972143+ENST00000546179ARNTL2chr1227521195+301113674992925808
ENST00000282516NIPBLchr536972143+ENST00000311001ARNTL2chr1227521195+320613674993204902
ENST00000282516NIPBLchr536972143+ENST00000261178ARNTL2chr1227521195+316113674993102867
ENST00000282516NIPBLchr536972143+ENST00000266503ARNTL2chr1227521195+360913674993246915
ENST00000448238NIPBLchr536972143+ENST00000544915ARNTL2chr1227521195+589013364683113881
ENST00000448238NIPBLchr536972143+ENST00000395901ARNTL2chr1227521195+307313364683071867
ENST00000448238NIPBLchr536972143+ENST00000546179ARNTL2chr1227521195+298013364682894808
ENST00000448238NIPBLchr536972143+ENST00000311001ARNTL2chr1227521195+317513364683173901
ENST00000448238NIPBLchr536972143+ENST00000261178ARNTL2chr1227521195+313013364683071867
ENST00000448238NIPBLchr536972143+ENST00000266503ARNTL2chr1227521195+357813364683215915

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000282516ENST00000544915NIPBLchr536972143+ARNTL2chr1227521195+0.0001151650.99988484
ENST00000282516ENST00000395901NIPBLchr536972143+ARNTL2chr1227521195+0.0004501050.9995499
ENST00000282516ENST00000546179NIPBLchr536972143+ARNTL2chr1227521195+0.0006385990.99936146
ENST00000282516ENST00000311001NIPBLchr536972143+ARNTL2chr1227521195+0.0004280690.999572
ENST00000282516ENST00000261178NIPBLchr536972143+ARNTL2chr1227521195+0.0004043670.9995957
ENST00000282516ENST00000266503NIPBLchr536972143+ARNTL2chr1227521195+0.0002544190.99974555
ENST00000448238ENST00000544915NIPBLchr536972143+ARNTL2chr1227521195+0.0001170090.99988294
ENST00000448238ENST00000395901NIPBLchr536972143+ARNTL2chr1227521195+0.0004797280.9995203
ENST00000448238ENST00000546179NIPBLchr536972143+ARNTL2chr1227521195+0.0006779310.99932206
ENST00000448238ENST00000311001NIPBLchr536972143+ARNTL2chr1227521195+0.0004578090.99954224
ENST00000448238ENST00000261178NIPBLchr536972143+ARNTL2chr1227521195+0.000427020.99957293
ENST00000448238ENST00000266503NIPBLchr536972143+ARNTL2chr1227521195+0.0002675090.99973243

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Fusion Genomic Features for NIPBL-ARNTL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NIPBLchr536972143+ARNTL2chr1227521194+0.0035588210.9964412
NIPBLchr536972143+ARNTL2chr1227521194+0.0035588210.9964412

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NIPBL-ARNTL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:36972143/chr12:27521195)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NIPBL

Q6KC79

ARNTL2

Q8WYA1

FUNCTION: Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}.FUNCTION: Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. The CLOCK-ARNTL2/BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. {ECO:0000269|PubMed:11018023, ECO:0000269|PubMed:12738229, ECO:0000269|PubMed:14672706}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneARNTL2chr5:36972143chr12:27521195ENST00000261178015107_16010589.0DomainbHLH
TgeneARNTL2chr5:36972143chr12:27521195ENST00000261178015178_25010589.0DomainPAS 1
TgeneARNTL2chr5:36972143chr12:27521195ENST00000261178015357_42710589.0DomainPAS 2
TgeneARNTL2chr5:36972143chr12:27521195ENST00000261178015432_47510589.0DomainNote=PAC
TgeneARNTL2chr5:36972143chr12:27521195ENST00000266503017107_16010637.0DomainbHLH
TgeneARNTL2chr5:36972143chr12:27521195ENST00000266503017178_25010637.0DomainPAS 1
TgeneARNTL2chr5:36972143chr12:27521195ENST00000266503017357_42710637.0DomainPAS 2
TgeneARNTL2chr5:36972143chr12:27521195ENST00000266503017432_47510637.0DomainNote=PAC
TgeneARNTL2chr5:36972143chr12:27521195ENST00000311001016107_16010623.0DomainbHLH
TgeneARNTL2chr5:36972143chr12:27521195ENST00000311001016178_25010623.0DomainPAS 1
TgeneARNTL2chr5:36972143chr12:27521195ENST00000311001016357_42710623.0DomainPAS 2
TgeneARNTL2chr5:36972143chr12:27521195ENST00000311001016432_47510623.0DomainNote=PAC
TgeneARNTL2chr5:36972143chr12:27521195ENST00000395901015107_16021600.0DomainbHLH
TgeneARNTL2chr5:36972143chr12:27521195ENST00000395901015178_25021600.0DomainPAS 1
TgeneARNTL2chr5:36972143chr12:27521195ENST00000395901015357_42721600.0DomainPAS 2
TgeneARNTL2chr5:36972143chr12:27521195ENST00000395901015432_47521600.0DomainNote=PAC
TgeneARNTL2chr5:36972143chr12:27521195ENST00000542388014107_1600552.0DomainbHLH
TgeneARNTL2chr5:36972143chr12:27521195ENST00000542388014178_2500552.0DomainPAS 1
TgeneARNTL2chr5:36972143chr12:27521195ENST00000542388014357_4270552.0DomainPAS 2
TgeneARNTL2chr5:36972143chr12:27521195ENST00000542388014432_4750552.0DomainNote=PAC
TgeneARNTL2chr5:36972143chr12:27521195ENST00000544915016107_16010603.0DomainbHLH
TgeneARNTL2chr5:36972143chr12:27521195ENST00000544915016178_25010603.0DomainPAS 1
TgeneARNTL2chr5:36972143chr12:27521195ENST00000544915016357_42710603.0DomainPAS 2
TgeneARNTL2chr5:36972143chr12:27521195ENST00000544915016432_47510603.0DomainNote=PAC
TgeneARNTL2chr5:36972143chr12:27521195ENST00000546179014107_16021541.0DomainbHLH
TgeneARNTL2chr5:36972143chr12:27521195ENST00000546179014178_25021541.0DomainPAS 1
TgeneARNTL2chr5:36972143chr12:27521195ENST00000546179014357_42721541.0DomainPAS 2
TgeneARNTL2chr5:36972143chr12:27521195ENST00000546179014432_47521541.0DomainNote=PAC
TgeneARNTL2chr5:36972143chr12:27521195ENST00000261178015177_18710589.0MotifNuclear export signal 1
TgeneARNTL2chr5:36972143chr12:27521195ENST00000261178015392_40010589.0MotifNuclear export signal 2
TgeneARNTL2chr5:36972143chr12:27521195ENST0000026117801549_5410589.0MotifNuclear localization signal
TgeneARNTL2chr5:36972143chr12:27521195ENST00000266503017177_18710637.0MotifNuclear export signal 1
TgeneARNTL2chr5:36972143chr12:27521195ENST00000266503017392_40010637.0MotifNuclear export signal 2
TgeneARNTL2chr5:36972143chr12:27521195ENST0000026650301749_5410637.0MotifNuclear localization signal
TgeneARNTL2chr5:36972143chr12:27521195ENST00000311001016177_18710623.0MotifNuclear export signal 1
TgeneARNTL2chr5:36972143chr12:27521195ENST00000311001016392_40010623.0MotifNuclear export signal 2
TgeneARNTL2chr5:36972143chr12:27521195ENST0000031100101649_5410623.0MotifNuclear localization signal
TgeneARNTL2chr5:36972143chr12:27521195ENST00000395901015177_18721600.0MotifNuclear export signal 1
TgeneARNTL2chr5:36972143chr12:27521195ENST00000395901015392_40021600.0MotifNuclear export signal 2
TgeneARNTL2chr5:36972143chr12:27521195ENST0000039590101549_5421600.0MotifNuclear localization signal
TgeneARNTL2chr5:36972143chr12:27521195ENST00000542388014177_1870552.0MotifNuclear export signal 1
TgeneARNTL2chr5:36972143chr12:27521195ENST00000542388014392_4000552.0MotifNuclear export signal 2
TgeneARNTL2chr5:36972143chr12:27521195ENST0000054238801449_540552.0MotifNuclear localization signal
TgeneARNTL2chr5:36972143chr12:27521195ENST00000544915016177_18710603.0MotifNuclear export signal 1
TgeneARNTL2chr5:36972143chr12:27521195ENST00000544915016392_40010603.0MotifNuclear export signal 2
TgeneARNTL2chr5:36972143chr12:27521195ENST0000054491501649_5410603.0MotifNuclear localization signal
TgeneARNTL2chr5:36972143chr12:27521195ENST00000546179014177_18721541.0MotifNuclear export signal 1
TgeneARNTL2chr5:36972143chr12:27521195ENST00000546179014392_40021541.0MotifNuclear export signal 2
TgeneARNTL2chr5:36972143chr12:27521195ENST0000054617901449_5421541.0MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNIPBLchr5:36972143chr12:27521195ENST00000282516+847418_4622892805.0Compositional biasNote=Gln-rich
HgeneNIPBLchr5:36972143chr12:27521195ENST00000448238+846418_4622892698.0Compositional biasNote=Gln-rich
HgeneNIPBLchr5:36972143chr12:27521195ENST00000282516+847996_10092892805.0MotifPxVxL motif
HgeneNIPBLchr5:36972143chr12:27521195ENST00000448238+846996_10092892698.0MotifPxVxL motif
HgeneNIPBLchr5:36972143chr12:27521195ENST00000282516+8471767_18052892805.0RepeatNote=HEAT 1
HgeneNIPBLchr5:36972143chr12:27521195ENST00000282516+8471843_18812892805.0RepeatNote=HEAT 2
HgeneNIPBLchr5:36972143chr12:27521195ENST00000282516+8471945_19842892805.0RepeatNote=HEAT 3
HgeneNIPBLchr5:36972143chr12:27521195ENST00000282516+8472227_22672892805.0RepeatNote=HEAT 4
HgeneNIPBLchr5:36972143chr12:27521195ENST00000282516+8472313_23512892805.0RepeatNote=HEAT 5
HgeneNIPBLchr5:36972143chr12:27521195ENST00000448238+8461767_18052892698.0RepeatNote=HEAT 1
HgeneNIPBLchr5:36972143chr12:27521195ENST00000448238+8461843_18812892698.0RepeatNote=HEAT 2
HgeneNIPBLchr5:36972143chr12:27521195ENST00000448238+8461945_19842892698.0RepeatNote=HEAT 3
HgeneNIPBLchr5:36972143chr12:27521195ENST00000448238+8462227_22672892698.0RepeatNote=HEAT 4
HgeneNIPBLchr5:36972143chr12:27521195ENST00000448238+8462313_23512892698.0RepeatNote=HEAT 5


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Fusion Gene Sequence for NIPBL-ARNTL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>59189_59189_1_NIPBL-ARNTL2_NIPBL_chr5_36972143_ENST00000282516_ARNTL2_chr12_27521195_ENST00000261178_length(transcript)=3161nt_BP=1367nt
TCCGGTCGGCATTTTGTTCTGAGAGGGAGAGACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTC
CGTCGGTACCGACTCACCCGACACCACCAAGCCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCC
CCCCCGGTAGCTCGGGCCCGTGGTCGGGTGTTTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGT
CTTCTCGGCTGGTCTCCCCCCGGCTCTACATGTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGAT
TATAGTCTCTCGCCACAGCGGCCTCGGCCTCCCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTG
GCACCTGAACTAAGTACTTTTATAGGCAACACCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGC
GGGGATTGCTAGTCTCACAGACCTCCTGAACCAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGC
ACGAATAGCAGAAGAGGTGAACTGCCTTTTGGCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAAC
AGATCACATAGAGTTGAAAGATAACCTTGGCAGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCC
TAATGTTTTCAGGGAGAAAAGCATGCAGAACAGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCA
CAGTAGTCCTGCATCTTCCAATTATCAACAAACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAA
CAGATTTATGCCACAGCAAAATAGCCCAGTGCCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAG
TTACACAACACATCCACAGATGCAACAAGCATCGGTATCAAGTCCCATTGTTGCAGGTGGTTTGAGAAACATACATGATAATAAAGTTTC
TGGTCCGTTGTCTGGCAATTCAGCTAATCATCATGCTGATAATCCTAGACATGGTTCAAGTGAGGACTACCTACACATGGTGCACAGGCT
AAGTAGTGACGATGGAGATTCTTCAACAATGAGGAATGCTGCATCTTTTCCCTTGAGATCTCCACAGCCAGTATGCTCCCCTGCTGGAAG
TGAAGGAACTCCTAAAGGTAAAGTGTTGAGAGAGGAGAACCAGTGCATTGCTCCTGTGGTTTCCAGCCGCGTGAGTCCAGGGACAAGACC
AACAGCTATGGGGTCTTTCAGCTCACACATGACAGAGTTTCCACGAAAACGCAAAGGAAGTGATTCAGACCCATCCCAAGAAGCTCATAG
CCAAACTGAAAAGCGGAGGAGAGATAAAATGAATAACCTGATTGAAGAACTGTCTGCAATGATCCCTCAGTGCAACCCCATGGCGCGTAA
ACTGGACAAACTTACAGTTTTAAGAATGGCTGTTCAACACTTGAGATCTTTAAAAGGCTTGACAAATTCTTATGTGGGAAGTAATTATAG
ACCATCATTTCTTCAGGATAATGAGCTCAGACATTTAATCCTTAAGACTGCAGAAGGCTTCTTATTTGTGGTTGGATGTGAAAGAGGAAA
AATTCTCTTCGTTTCTAAGTCAGTCTCCAAAATACTTAATTATGATCAGGCTAGTTTGACTGGACAAAGCTTATTTGACTTCTTACATCC
AAAAGATGTTGCCAAAGTAAAGGAACAACTTTCTTCTTTTGATATTTCACCAAGAGAAAAGCTAATAGATGCCAAAACTGGTTTGCAAGT
TCACAGTAATCTCCACGCTGGAAGGACACGTGTGTATTCTGGCTCAAGACGATCTTTTTTCTGTCGGATAAAGAGTTGTAAAATCTCTGT
CAAAGAAGAGCATGGATGCTTACCCAACTCAAAGAAGAAAGAGCACAGAAAATTCTATACTATCCATTGCACTGGTTACTTGAGAAGCTG
GCCTCCAAATATTGTTGGAATGGAAGAAGAAAGGAACAGTAAGAAAGACAACAGTAATTTTACCTGCCTTGTGGCCATTGGAAGATTACA
GCCATATATTGTTCCACAGAACAGTGGAGAGATTAATGTGAAACCAACTGAATTTATAACCCGGTTTGCAGTGAATGGAAAATTTGTCTA
TGTAGATCAAAGGGCAACAGCGATTTTAGGATATCTGCCTCAGGAACTTTTGGGAACTTCTTGTTATGAATATTTTCATCAAGATGACCA
CAATAATTTGACTGACAAGCACAAAGCAGTTCTACAGAGTAAGGAGAAAATACTTACAGATTCCTACAAATTCAGAGCAAAAGATGGCTC
TTTTGTAACTTTAAAAAGCCAATGGTTTAGTTTCACAAATCCTTGGACAAAAGAACTGGAATATATTGTATCTGTCAACACTTTAGTTTT
GGGACATAGTGAGCCTGGAGAAGCATCATTTTTACCTTGTAGCTCTCAATCATCAGAAGAATCCTCTAGACAGTCCTGTATGAGTGTACC
TGGAATGTCTACTGGAACAGTACTTGGTGCTGGTAGTATTGGAACAGATATTGCAAATGAAATTCTGGATTTACAGAGGTTACAGTCTTC
TTCATACCTTGATGATTCGAGTCCAACAGGTTTAATGAAAGATACTCATACTGTAAACTGCAGGAGTATGTCAAATAAGGAGTTGTTTCC
ACCAAGTCCTTCTGAAATGGGGGAGCTAGAGGCTACCAGGCAAAACCAGAGTACTGTTGCTGTCCACAGCCATGAGCCACTCCTCAGTGA
TGGTGCACAGTTGGATTTCGATGCCCTATGTGACAATGATGACACAGCCATGGCTGCATTTATGAATTACTTAGAAGCAGAGGGGGGCCT
GGGAGACCCTGGGGACTTCAGTGACATCCAGTGGACCCTCTAGCCTTTGATTTTTAACTCCAAAAATGAGAAACATTTTAAAGCATTTCA

>59189_59189_1_NIPBL-ARNTL2_NIPBL_chr5_36972143_ENST00000282516_ARNTL2_chr12_27521195_ENST00000261178_length(amino acids)=867AA_BP=287
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASF
PLRSPQPVCSPAGSEGTPKGKVLREENQCIAPVVSSRVSPGTRPTAMGSFSSHMTEFPRKRKGSDSDPSQEAHSQTEKRRRDKMNNLIEE
LSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQ
ASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHR
KFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQEL
LGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTLVLGHSEPGEASFLPCSSQ
SSEESSRQSCMSVPGMSTGTVLGAGSIGTDIANEILDLQRLQSSSYLDDSSPTGLMKDTHTVNCRSMSNKELFPPSPSEMGELEATRQNQ

--------------------------------------------------------------
>59189_59189_2_NIPBL-ARNTL2_NIPBL_chr5_36972143_ENST00000282516_ARNTL2_chr12_27521195_ENST00000266503_length(transcript)=3609nt_BP=1367nt
TCCGGTCGGCATTTTGTTCTGAGAGGGAGAGACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTC
CGTCGGTACCGACTCACCCGACACCACCAAGCCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCC
CCCCCGGTAGCTCGGGCCCGTGGTCGGGTGTTTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGT
CTTCTCGGCTGGTCTCCCCCCGGCTCTACATGTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGAT
TATAGTCTCTCGCCACAGCGGCCTCGGCCTCCCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTG
GCACCTGAACTAAGTACTTTTATAGGCAACACCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGC
GGGGATTGCTAGTCTCACAGACCTCCTGAACCAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGC
ACGAATAGCAGAAGAGGTGAACTGCCTTTTGGCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAAC
AGATCACATAGAGTTGAAAGATAACCTTGGCAGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCC
TAATGTTTTCAGGGAGAAAAGCATGCAGAACAGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCA
CAGTAGTCCTGCATCTTCCAATTATCAACAAACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAA
CAGATTTATGCCACAGCAAAATAGCCCAGTGCCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAG
TTACACAACACATCCACAGATGCAACAAGCATCGGTATCAAGTCCCATTGTTGCAGGTGGTTTGAGAAACATACATGATAATAAAGTTTC
TGGTCCGTTGTCTGGCAATTCAGCTAATCATCATGCTGATAATCCTAGACATGGTTCAAGTGAGGACTACCTACACATGGTGCACAGGCT
AAGTAGTGACGATGGAGATTCTTCAACAATGAGGAATGCTGCATCTTTTCCCTTGAGATCTCCACAGCCAGTATGCTCCCCTGCTGGAAG
TGAAGGAACTCCTAAAGGTAAAGTGTTGAGAGAGGAGAACCAGTGCATTGCTCCTGTGGTTTCCAGCCGCGTGAGTCCAGGGACAAGACC
AACAGCTATGGGGTCTTTCAGCTCACACATGACAGAGTTTCCACGAAAACGCAAAGGAAGTGATTCAGACCCATCCCAGTCAGGAATCAT
GACAGAAAAAGTGGTGGAAAAGCTTTCTCAGAATCCCCTTACCTATCTTCTTTCAACAAGGATAGAAATATCAGCCTCCAGTGGCAGCAG
AGTGGAAGATGGTGAACACCAAGTTAAAATGAAGGCCTTCAGAGAAGCTCATAGCCAAACTGAAAAGCGGAGGAGAGATAAAATGAATAA
CCTGATTGAAGAACTGTCTGCAATGATCCCTCAGTGCAACCCCATGGCGCGTAAACTGGACAAACTTACAGTTTTAAGAATGGCTGTTCA
ACACTTGAGATCTTTAAAAGGCTTGACAAATTCTTATGTGGGAAGTAATTATAGACCATCATTTCTTCAGGATAATGAGCTCAGACATTT
AATCCTTAAGACTGCAGAAGGCTTCTTATTTGTGGTTGGATGTGAAAGAGGAAAAATTCTCTTCGTTTCTAAGTCAGTCTCCAAAATACT
TAATTATGATCAGGCTAGTTTGACTGGACAAAGCTTATTTGACTTCTTACATCCAAAAGATGTTGCCAAAGTAAAGGAACAACTTTCTTC
TTTTGATATTTCACCAAGAGAAAAGCTAATAGATGCCAAAACTGGTTTGCAAGTTCACAGTAATCTCCACGCTGGAAGGACACGTGTGTA
TTCTGGCTCAAGACGATCTTTTTTCTGTCGGATAAAGAGTTGTAAAATCTCTGTCAAAGAAGAGCATGGATGCTTACCCAACTCAAAGAA
GAAAGAGCACAGAAAATTCTATACTATCCATTGCACTGGTTACTTGAGAAGCTGGCCTCCAAATATTGTTGGAATGGAAGAAGAAAGGAA
CAGTAAGAAAGACAACAGTAATTTTACCTGCCTTGTGGCCATTGGAAGATTACAGCCATATATTGTTCCACAGAACAGTGGAGAGATTAA
TGTGAAACCAACTGAATTTATAACCCGGTTTGCAGTGAATGGAAAATTTGTCTATGTAGATCAAAGGGCAACAGCGATTTTAGGATATCT
GCCTCAGGAACTTTTGGGAACTTCTTGTTATGAATATTTTCATCAAGATGACCACAATAATTTGACTGACAAGCACAAAGCAGTTCTACA
GAGTAAGGAGAAAATACTTACAGATTCCTACAAATTCAGAGCAAAAGATGGCTCTTTTGTAACTTTAAAAAGCCAATGGTTTAGTTTCAC
AAATCCTTGGACAAAAGAACTGGAATATATTGTATCTGTCAACACTTTAGTTTTGGGACATAGTGAGCCTGGAGAAGCATCATTTTTACC
TTGTAGCTCTCAATCATCAGAAGAATCCTCTAGACAGTCCTGTATGAGTGTACCTGGAATGTCTACTGGAACAGTACTTGGTGCTGGTAG
TATTGGAACAGATATTGCAAATGAAATTCTGGATTTACAGAGGTTACAGTCTTCTTCATACCTTGATGATTCGAGTCCAACAGGTTTAAT
GAAAGATACTCATACTGTAAACTGCAGGAGTATGTCAAATAAGGAGTTGTTTCCACCAAGTCCTTCTGAAATGGGGGAGCTAGAGGCTAC
CAGGCAAAACCAGAGTACTGTTGCTGTCCACAGCCATGAGCCACTCCTCAGTGATGGTGCACAGTTGGATTTCGATGCCCTATGTGACAA
TGATGACACAGCCATGGCTGCATTTATGAATTACTTAGAAGCAGAGGGGGGCCTGGGAGACCCTGGGGACTTCAGTGACATCCAGTGGAC
CCTCTAGCCTTTGATTTTTAACTCCAAAAATGAGAAACATTTTAAAGCATTTCATTTACGAAAAACTGTCTCAACTATTCTTAAGTACTG
TATTGATATTGTTTGTATCTTTTATTAATGTTCTACCACTTTTTATAGATTTGCATCTTCCTGTCACAGGGATGTGGGGAAATACGTTTT
CCTCCCAAGAGAACCAAGTTTATTATAGACTCCTTTATTCAGTGAAATGGCTTATAATCCACTAGTTGCCATATTTTTGCTAAAATATTT
CTAACCAAGAATACTACTTACATATTGTTTTGGCTTTGTTTTATTTTTGATGCAGTTTTTTTTAGTTGAGGTAATGTAATATATTGATGT

>59189_59189_2_NIPBL-ARNTL2_NIPBL_chr5_36972143_ENST00000282516_ARNTL2_chr12_27521195_ENST00000266503_length(amino acids)=915AA_BP=287
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASF
PLRSPQPVCSPAGSEGTPKGKVLREENQCIAPVVSSRVSPGTRPTAMGSFSSHMTEFPRKRKGSDSDPSQSGIMTEKVVEKLSQNPLTYL
LSTRIEISASSGSRVEDGEHQVKMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYVGSN
YRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGL
QVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGR
LQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKD
GSFVTLKSQWFSFTNPWTKELEYIVSVNTLVLGHSEPGEASFLPCSSQSSEESSRQSCMSVPGMSTGTVLGAGSIGTDIANEILDLQRLQ
SSSYLDDSSPTGLMKDTHTVNCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEG

--------------------------------------------------------------
>59189_59189_3_NIPBL-ARNTL2_NIPBL_chr5_36972143_ENST00000282516_ARNTL2_chr12_27521195_ENST00000311001_length(transcript)=3206nt_BP=1367nt
TCCGGTCGGCATTTTGTTCTGAGAGGGAGAGACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTC
CGTCGGTACCGACTCACCCGACACCACCAAGCCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCC
CCCCCGGTAGCTCGGGCCCGTGGTCGGGTGTTTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGT
CTTCTCGGCTGGTCTCCCCCCGGCTCTACATGTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGAT
TATAGTCTCTCGCCACAGCGGCCTCGGCCTCCCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTG
GCACCTGAACTAAGTACTTTTATAGGCAACACCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGC
GGGGATTGCTAGTCTCACAGACCTCCTGAACCAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGC
ACGAATAGCAGAAGAGGTGAACTGCCTTTTGGCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAAC
AGATCACATAGAGTTGAAAGATAACCTTGGCAGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCC
TAATGTTTTCAGGGAGAAAAGCATGCAGAACAGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCA
CAGTAGTCCTGCATCTTCCAATTATCAACAAACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAA
CAGATTTATGCCACAGCAAAATAGCCCAGTGCCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAG
TTACACAACACATCCACAGATGCAACAAGCATCGGTATCAAGTCCCATTGTTGCAGGTGGTTTGAGAAACATACATGATAATAAAGTTTC
TGGTCCGTTGTCTGGCAATTCAGCTAATCATCATGCTGATAATCCTAGACATGGTTCAAGTGAGGACTACCTACACATGGTGCACAGGCT
AAGTAGTGACGATGGAGATTCTTCAACAATGAGGAATGCTGCATCTTTTCCCTTGAGATCTCCACAGCCAGTATGCTCCCCTGCTGGAAG
TGAAGGAACTCCTAAAGGTAAAGTGTTGAGAGAGGAGAACCAGTGCATTGCTCCTGTGGTTTCCAGCCGCGTGAGTCCAGGGACAAGACC
AACAGCTATGGGGTCTTTCAGCTCACACATGACAGAGTTTCCACGAAAACGCAAAGGAAGTGATTCAGACCCATCCCAGTCAGGAATCAT
GACAGAAAAAGTGGTGGAAAAGCTTTCTCAGAATCCCCTTACCTATCTTCTTTCAACAAGGATAGAAATATCAGCCTCCAGTGGCAGCAG
AGAAGCTCATAGCCAAACTGAAAAGCGGAGGAGAGATAAAATGAATAACCTGATTGAAGAACTGTCTGCAATGATCCCTCAGTGCAACCC
CATGGCGCGTAAACTGGACAAACTTACAGTTTTAAGAATGGCTGTTCAACACTTGAGATCTTTAAAAGGCTTGACAAATTCTTATGTGGG
AAGTAATTATAGACCATCATTTCTTCAGGATAATGAGCTCAGACATTTAATCCTTAAGACTGCAGAAGGCTTCTTATTTGTGGTTGGATG
TGAAAGAGGAAAAATTCTCTTCGTTTCTAAGTCAGTCTCCAAAATACTTAATTATGATCAGGCTAGTTTGACTGGACAAAGCTTATTTGA
CTTCTTACATCCAAAAGATGTTGCCAAAGTAAAGGAACAACTTTCTTCTTTTGATATTTCACCAAGAGAAAAGCTAATAGATGCCAAAAC
TGGTTTGCAAGTTCACAGTAATCTCCACGCTGGAAGGACACGTGTGTATTCTGGCTCAAGACGATCTTTTTTCTGTCGGATAAAGAGTTG
TAAAATCTCTGTCAAAGAAGAGCATGGATGCTTACCCAACTCAAAGAAGAAAGAGCACAGAAAATTCTATACTATCCATTGCACTGGTTA
CTTGAGAAGCTGGCCTCCAAATATTGTTGGAATGGAAGAAGAAAGGAACAGTAAGAAAGACAACAGTAATTTTACCTGCCTTGTGGCCAT
TGGAAGATTACAGCCATATATTGTTCCACAGAACAGTGGAGAGATTAATGTGAAACCAACTGAATTTATAACCCGGTTTGCAGTGAATGG
AAAATTTGTCTATGTAGATCAAAGGGCAACAGCGATTTTAGGATATCTGCCTCAGGAACTTTTGGGAACTTCTTGTTATGAATATTTTCA
TCAAGATGACCACAATAATTTGACTGACAAGCACAAAGCAGTTCTACAGAGTAAGGAGAAAATACTTACAGATTCCTACAAATTCAGAGC
AAAAGATGGCTCTTTTGTAACTTTAAAAAGCCAATGGTTTAGTTTCACAAATCCTTGGACAAAAGAACTGGAATATATTGTATCTGTCAA
CACTTTAGTTTTGGGACATAGTGAGCCTGGAGAAGCATCATTTTTACCTTGTAGCTCTCAATCATCAGAAGAATCCTCTAGACAGTCCTG
TATGAGTGTACCTGGAATGTCTACTGGAACAGTACTTGGTGCTGGTAGTATTGGAACAGATATTGCAAATGAAATTCTGGATTTACAGAG
GTTACAGTCTTCTTCATACCTTGATGATTCGAGTCCAACAGGTTTAATGAAAGATACTCATACTGTAAACTGCAGGAGTATGTCAAATAA
GGAGTTGTTTCCACCAAGTCCTTCTGAAATGGGGGAGCTAGAGGCTACCAGGCAAAACCAGAGTACTGTTGCTGTCCACAGCCATGAGCC
ACTCCTCAGTGATGGTGCACAGTTGGATTTCGATGCCCTATGTGACAATGATGACACAGCCATGGCTGCATTTATGAATTACTTAGAAGC

>59189_59189_3_NIPBL-ARNTL2_NIPBL_chr5_36972143_ENST00000282516_ARNTL2_chr12_27521195_ENST00000311001_length(amino acids)=902AA_BP=287
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASF
PLRSPQPVCSPAGSEGTPKGKVLREENQCIAPVVSSRVSPGTRPTAMGSFSSHMTEFPRKRKGSDSDPSQSGIMTEKVVEKLSQNPLTYL
LSTRIEISASSGSREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYVGSNYRPSFLQDNELRHL
ILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVY
SGSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEIN
VKPTEFITRFAVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFT
NPWTKELEYIVSVNTLVLGHSEPGEASFLPCSSQSSEESSRQSCMSVPGMSTGTVLGAGSIGTDIANEILDLQRLQSSSYLDDSSPTGLM
KDTHTVNCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWT

--------------------------------------------------------------
>59189_59189_4_NIPBL-ARNTL2_NIPBL_chr5_36972143_ENST00000282516_ARNTL2_chr12_27521195_ENST00000395901_length(transcript)=3104nt_BP=1367nt
TCCGGTCGGCATTTTGTTCTGAGAGGGAGAGACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTC
CGTCGGTACCGACTCACCCGACACCACCAAGCCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCC
CCCCCGGTAGCTCGGGCCCGTGGTCGGGTGTTTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGT
CTTCTCGGCTGGTCTCCCCCCGGCTCTACATGTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGAT
TATAGTCTCTCGCCACAGCGGCCTCGGCCTCCCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTG
GCACCTGAACTAAGTACTTTTATAGGCAACACCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGC
GGGGATTGCTAGTCTCACAGACCTCCTGAACCAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGC
ACGAATAGCAGAAGAGGTGAACTGCCTTTTGGCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAAC
AGATCACATAGAGTTGAAAGATAACCTTGGCAGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCC
TAATGTTTTCAGGGAGAAAAGCATGCAGAACAGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCA
CAGTAGTCCTGCATCTTCCAATTATCAACAAACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAA
CAGATTTATGCCACAGCAAAATAGCCCAGTGCCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAG
TTACACAACACATCCACAGATGCAACAAGCATCGGTATCAAGTCCCATTGTTGCAGGTGGTTTGAGAAACATACATGATAATAAAGTTTC
TGGTCCGTTGTCTGGCAATTCAGCTAATCATCATGCTGATAATCCTAGACATGGTTCAAGTGAGGACTACCTACACATGGTGCACAGGCT
AAGTAGTGACGATGGAGATTCTTCAACAATGAGGAATGCTGCATCTTTTCCCTTGAGATCTCCACAGCCAGTATGCTCCCCTGCTGGAAG
TGAAGGAACTCCTAAAGGTAAAGTGTTGAGAGAGGAGAACCAGTGCATTGCTCCTGTGGTTTCCAGCCGCGTGAGTCCAGGGACAAGACC
AACAGCTATGGGGTCTTTCAGCTCACACATGACAGAGTTTCCACGAAAACGCAAAGGAAGTGATTCAGACCCATCCCAAGAAGCTCATAG
CCAAACTGAAAAGCGGAGGAGAGATAAAATGAATAACCTGATTGAAGAACTGTCTGCAATGATCCCTCAGTGCAACCCCATGGCGCGTAA
ACTGGACAAACTTACAGTTTTAAGAATGGCTGTTCAACACTTGAGATCTTTAAAAGGCTTGACAAATTCTTATGTGGGAAGTAATTATAG
ACCATCATTTCTTCAGGATAATGAGCTCAGACATTTAATCCTTAAGACTGCAGAAGGCTTCTTATTTGTGGTTGGATGTGAAAGAGGAAA
AATTCTCTTCGTTTCTAAGTCAGTCTCCAAAATACTTAATTATGATCAGGCTAGTTTGACTGGACAAAGCTTATTTGACTTCTTACATCC
AAAAGATGTTGCCAAAGTAAAGGAACAACTTTCTTCTTTTGATATTTCACCAAGAGAAAAGCTAATAGATGCCAAAACTGGTTTGCAAGT
TCACAGTAATCTCCACGCTGGAAGGACACGTGTGTATTCTGGCTCAAGACGATCTTTTTTCTGTCGGATAAAGAGTTGTAAAATCTCTGT
CAAAGAAGAGCATGGATGCTTACCCAACTCAAAGAAGAAAGAGCACAGAAAATTCTATACTATCCATTGCACTGGTTACTTGAGAAGCTG
GCCTCCAAATATTGTTGGAATGGAAGAAGAAAGGAACAGTAAGAAAGACAACAGTAATTTTACCTGCCTTGTGGCCATTGGAAGATTACA
GCCATATATTGTTCCACAGAACAGTGGAGAGATTAATGTGAAACCAACTGAATTTATAACCCGGTTTGCAGTGAATGGAAAATTTGTCTA
TGTAGATCAAAGGGCAACAGCGATTTTAGGATATCTGCCTCAGGAACTTTTGGGAACTTCTTGTTATGAATATTTTCATCAAGATGACCA
CAATAATTTGACTGACAAGCACAAAGCAGTTCTACAGAGTAAGGAGAAAATACTTACAGATTCCTACAAATTCAGAGCAAAAGATGGCTC
TTTTGTAACTTTAAAAAGCCAATGGTTTAGTTTCACAAATCCTTGGACAAAAGAACTGGAATATATTGTATCTGTCAACACTTTAGTTTT
GGGACATAGTGAGCCTGGAGAAGCATCATTTTTACCTTGTAGCTCTCAATCATCAGAAGAATCCTCTAGACAGTCCTGTATGAGTGTACC
TGGAATGTCTACTGGAACAGTACTTGGTGCTGGTAGTATTGGAACAGATATTGCAAATGAAATTCTGGATTTACAGAGGTTACAGTCTTC
TTCATACCTTGATGATTCGAGTCCAACAGGTTTAATGAAAGATACTCATACTGTAAACTGCAGGAGTATGTCAAATAAGGAGTTGTTTCC
ACCAAGTCCTTCTGAAATGGGGGAGCTAGAGGCTACCAGGCAAAACCAGAGTACTGTTGCTGTCCACAGCCATGAGCCACTCCTCAGTGA
TGGTGCACAGTTGGATTTCGATGCCCTATGTGACAATGATGACACAGCCATGGCTGCATTTATGAATTACTTAGAAGCAGAGGGGGGCCT

>59189_59189_4_NIPBL-ARNTL2_NIPBL_chr5_36972143_ENST00000282516_ARNTL2_chr12_27521195_ENST00000395901_length(amino acids)=868AA_BP=287
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASF
PLRSPQPVCSPAGSEGTPKGKVLREENQCIAPVVSSRVSPGTRPTAMGSFSSHMTEFPRKRKGSDSDPSQEAHSQTEKRRRDKMNNLIEE
LSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQ
ASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHR
KFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQEL
LGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTLVLGHSEPGEASFLPCSSQ
SSEESSRQSCMSVPGMSTGTVLGAGSIGTDIANEILDLQRLQSSSYLDDSSPTGLMKDTHTVNCRSMSNKELFPPSPSEMGELEATRQNQ

--------------------------------------------------------------
>59189_59189_5_NIPBL-ARNTL2_NIPBL_chr5_36972143_ENST00000282516_ARNTL2_chr12_27521195_ENST00000544915_length(transcript)=5921nt_BP=1367nt
TCCGGTCGGCATTTTGTTCTGAGAGGGAGAGACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTC
CGTCGGTACCGACTCACCCGACACCACCAAGCCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCC
CCCCCGGTAGCTCGGGCCCGTGGTCGGGTGTTTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGT
CTTCTCGGCTGGTCTCCCCCCGGCTCTACATGTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGAT
TATAGTCTCTCGCCACAGCGGCCTCGGCCTCCCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTG
GCACCTGAACTAAGTACTTTTATAGGCAACACCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGC
GGGGATTGCTAGTCTCACAGACCTCCTGAACCAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGC
ACGAATAGCAGAAGAGGTGAACTGCCTTTTGGCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAAC
AGATCACATAGAGTTGAAAGATAACCTTGGCAGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCC
TAATGTTTTCAGGGAGAAAAGCATGCAGAACAGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCA
CAGTAGTCCTGCATCTTCCAATTATCAACAAACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAA
CAGATTTATGCCACAGCAAAATAGCCCAGTGCCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAG
TTACACAACACATCCACAGATGCAACAAGCATCGGTATCAAGTCCCATTGTTGCAGGTGGTTTGAGAAACATACATGATAATAAAGTTTC
TGGTCCGTTGTCTGGCAATTCAGCTAATCATCATGCTGATAATCCTAGACATGGTTCAAGTGAGGACTACCTACACATGGTGCACAGGCT
AAGTAGTGACGATGGAGATTCTTCAACAATGAGGAATGCTGCATCTTTTCCCTTGAGATCTCCACAGCCAGTATGCTCCCCTGCTGGAAG
TGAAGGAACTCCTAAAGGTAAAGTGTTGAGAGAGGAGAACCAGTGCATTGCTCCTGTGGTTTCCAGCCGCGTGAGTCCAGGGACAAGACC
AACAGCTATGGGGTCTTTCAGCTCACACATGACAGAGTTTCCACGAAAACGCAAAGGAAGTGATTCAGACCCATCCCAAGTGGAAGATGG
TGAACACCAAGTTAAAATGAAGGCCTTCAGAGAAGCTCATAGCCAAACTGAAAAGCGGAGGAGAGATAAAATGAATAACCTGATTGAAGA
ACTGTCTGCAATGATCCCTCAGTGCAACCCCATGGCGCGTAAACTGGACAAACTTACAGTTTTAAGAATGGCTGTTCAACACTTGAGATC
TTTAAAAGGCTTGACAAATTCTTATGTGGGAAGTAATTATAGACCATCATTTCTTCAGGATAATGAGCTCAGACATTTAATCCTTAAGAC
TGCAGAAGGCTTCTTATTTGTGGTTGGATGTGAAAGAGGAAAAATTCTCTTCGTTTCTAAGTCAGTCTCCAAAATACTTAATTATGATCA
GGCTAGTTTGACTGGACAAAGCTTATTTGACTTCTTACATCCAAAAGATGTTGCCAAAGTAAAGGAACAACTTTCTTCTTTTGATATTTC
ACCAAGAGAAAAGCTAATAGATGCCAAAACTGGTTTGCAAGTTCACAGTAATCTCCACGCTGGAAGGACACGTGTGTATTCTGGCTCAAG
ACGATCTTTTTTCTGTCGGATAAAGAGTTGTAAAATCTCTGTCAAAGAAGAGCATGGATGCTTACCCAACTCAAAGAAGAAAGAGCACAG
AAAATTCTATACTATCCATTGCACTGGTTACTTGAGAAGCTGGCCTCCAAATATTGTTGGAATGGAAGAAGAAAGGAACAGTAAGAAAGA
CAACAGTAATTTTACCTGCCTTGTGGCCATTGGAAGATTACAGCCATATATTGTTCCACAGAACAGTGGAGAGATTAATGTGAAACCAAC
TGAATTTATAACCCGGTTTGCAGTGAATGGAAAATTTGTCTATGTAGATCAAAGGGCAACAGCGATTTTAGGATATCTGCCTCAGGAACT
TTTGGGAACTTCTTGTTATGAATATTTTCATCAAGATGACCACAATAATTTGACTGACAAGCACAAAGCAGTTCTACAGAGTAAGGAGAA
AATACTTACAGATTCCTACAAATTCAGAGCAAAAGATGGCTCTTTTGTAACTTTAAAAAGCCAATGGTTTAGTTTCACAAATCCTTGGAC
AAAAGAACTGGAATATATTGTATCTGTCAACACTTTAGTTTTGGGACATAGTGAGCCTGGAGAAGCATCATTTTTACCTTGTAGCTCTCA
ATCATCAGAAGAATCCTCTAGACAGTCCTGTATGAGTGTACCTGGAATGTCTACTGGAACAGTACTTGGTGCTGGTAGTATTGGAACAGA
TATTGCAAATGAAATTCTGGATTTACAGAGGTTACAGTCTTCTTCATACCTTGATGATTCGAGTCCAACAGGTTTAATGAAAGATACTCA
TACTGTAAACTGCAGGAGTATGTCAAATAAGGAGTTGTTTCCACCAAGTCCTTCTGAAATGGGGGAGCTAGAGGCTACCAGGCAAAACCA
GAGTACTGTTGCTGTCCACAGCCATGAGCCACTCCTCAGTGATGGTGCACAGTTGGATTTCGATGCCCTATGTGACAATGATGACACAGC
CATGGCTGCATTTATGAATTACTTAGAAGCAGAGGGGGGCCTGGGAGACCCTGGGGACTTCAGTGACATCCAGTGGACCCTCTAGCCTTT
GATTTTTAACTCCAAAAATGAGAAACATTTTAAAGCATTTCATTTACGAAAAACTGTCTCAACTATTCTTAAGTACTGTATTGATATTGT
TTGTATCTTTTATTAATGTTCTACCACTTTTTATAGATTTGCATCTTCCTGTCACAGGGATGTGGGGAAATACGTTTTCCTCCCAAGAGA
ACCAAGTTTATTATAGACTCCTTTATTCAGTGAAATGGCTTATAATCCACTAGTTGCCATATTTTTGCTAAAATATTTCTAACCAAGAAT
ACTACTTACATATTGTTTTGGCTTTGTTTTATTTTTGATGCAGTTTTTTTTAGTTGAGGTAATGTAATATATTGATGTTTTCCTTTGTGT
CTAAGATTCATTTATAATAGTAGGTTTGTATAATTTGGAACATTTTCCATTCCTTGCGAATTTCCTTAATTGAGGATAGGGCTTACACAC
TTTAAGAAAACAGTGAGTACTTGAACATTTAAAGGGACAGTGCAATTTATAGTCATAATCACATTGAATACTGTATTTGATCTTTGGAGA
CTTAGGCAAGCACAGAGCTGGGATATTTATGCTCAGTTGAGCACTTTAAGATGAATTTTAAGTGAGATGATTTCTTGCTTAAAACTCAGA
AAGTCAAAAGAGTTTCAGCTTTCCTTACAGAAAAGGAAGGATCTTGGGCCCTAGATCTTGGGGATTAACCTCTGCATATAAGATTTACTC
TTAATAGGCCAGACGTGGTGGCTCACGCCTGTAATCCCAGTACTTTGGGAGGCTGAGACGGGCAGATCACTTGAGGTCAGGAGTTCAAGA
CCAGCCTGGCCAATATGGTGAAACCCCGTTTCTACTAAAAATACAAAAAAAATTACCCAGGCACTCACTCTTGAGGTAACTAACCAACTC
CCACGATAATGACAGTCCATTCATGAGCGCAAAGGCCTCATGACCTAATGGCACACACCTGTAATCCCAACTGCTTGGGAGGCTGAGGCG
AGAGGATTGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCGAGATCGCACCACTGCACTCCAGTCTGGGCAACAGAGTGAGACTTCAT
CTCAAAAAAAGTAAAAAAAAAGATTTAATATAATCACTGAAGATCTCTATTATAGATAGATTAGGTTTTTGACATTGGAAACATACTTAG
GGATAGATTTGTCCTAAAGGAAAAAAGTAGGCCCGGGCAGATTAAATGTCTTGTGTAAAGTCACACATTAAATTCAGTCACACATTAAAT
TCATAGAGTTTTAAATGTTTAATGTATATAAACCAGTTTCTTTATACACATTTGGGAAAACATTGGTCTCACAGATTAAATGATTAACTA
ACTGACCCAGGAACTAGTTGTAGCTTTCTAAGTAATTAGGCAATTACAGTTATTGCCTGTAACCAAAGGTAATAAAACAAAATGACAAGT
ACATGTTTAAAATTATGAGGCAATGAGAAATAATTTAAAAACCAATTTTCTAGTTATAATTTAAAATTTGGAGAGCATTTTTAACAGTAA
TTAATCCAGAGGTGGCTCAAATTGAGTATAAGAATTAAGATTATTTAAAATACTGCATGTCTACCTTCTCGGGGATCATACTTTATAACA
CTTTCTGCTTCAGTAGCTCTTCATAGCTTGCCAAGTATGCTCCCATATTTTCTCTCTCGTGCCTCGCAAATGAAAGTCAGATAGGCTGGG
AACTCATGGGGCAGCCCTCAGACTTCAATGTGGGCTTCAAATCCAGTTTCCTGTTCTATATGGTGCTACATCTTTCCAGAAAATTTCCCT
CAGAGCCCCTCGCCAAAACAAAGCATTATTTTGACCCTGCATGCTATTTCTTTAGCTGTAGGTGATAGATTAGAACTTCTGTCAGACATG
TTAATGACAAACATACCAACAGACAATAACCAAAAGCAAATGTTTCCTTCAAGTGTGAAATGTGCAGGGGCTTCGTGGGCAAGGATGTAT
TGGCACACTGTCCTCTTGAACTGATAGTGTCCCAGCAATGTTGGAGGGTTGGCACCATTCCTGGTCCGACACTTGAGGACCTGAGAGACA
TCAGGTTTAGAATGAGCCAAAGAAATCCTACAAGATGGGGAGAATTGGTGTGCAGCAGCCTAAGTGTTATAGTTAAGTCTAAAGAAGTAT
GAAAGATCCCCTGTGTTCTCTAAATTGAGCAGAGGGGCCTGCCTACCAATATCACTTTTTAGGGGACTGAACCATTGCAGGTTAGACTTG
GCTTCCAAAGAGTCTGCCTAAGCCAGGGGTGGCAGGGTAGGCCATCATAGCTGGATGGCCTCAAAAGCAGATGGGGGCAGACTTGCCCTC
GTGATGCCAGGATTTGAGAGGCAGAGTTTCTAGAGGGAGACCAGTGCTGCCTCTCACAGTGGCAGTTTTTTCTCTTTGCAAGAGGAGGGG
CTGTTCAATTCCATAGACCAGTGGGCAGATAGCCAGTTGAATACTCTGTGCATGGTTTGATCCTTTATTAGTTCGCTCTAATATTTTTCT
GTAGATCCTTTTGTCCTGGACTCAAAATCTAATCCATGCATTGTATGATACCGTAGCTCTCCTAAGGTTTGTGTTTCCTTCAAAATGTTT
TAGTTTTCTTCAACTAAATTTGATTTTTGCTGTTAGAAGTGACATATTTTTATGGTATACACTATGTTCCTTTTTTCTACTGCGAGTCAA

>59189_59189_5_NIPBL-ARNTL2_NIPBL_chr5_36972143_ENST00000282516_ARNTL2_chr12_27521195_ENST00000544915_length(amino acids)=881AA_BP=287
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASF
PLRSPQPVCSPAGSEGTPKGKVLREENQCIAPVVSSRVSPGTRPTAMGSFSSHMTEFPRKRKGSDSDPSQVEDGEHQVKMKAFREAHSQT
EKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKIL
FVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKE
EHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVD
QRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTLVLGH
SEPGEASFLPCSSQSSEESSRQSCMSVPGMSTGTVLGAGSIGTDIANEILDLQRLQSSSYLDDSSPTGLMKDTHTVNCRSMSNKELFPPS

--------------------------------------------------------------
>59189_59189_6_NIPBL-ARNTL2_NIPBL_chr5_36972143_ENST00000282516_ARNTL2_chr12_27521195_ENST00000546179_length(transcript)=3011nt_BP=1367nt
TCCGGTCGGCATTTTGTTCTGAGAGGGAGAGACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTC
CGTCGGTACCGACTCACCCGACACCACCAAGCCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCC
CCCCCGGTAGCTCGGGCCCGTGGTCGGGTGTTTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGT
CTTCTCGGCTGGTCTCCCCCCGGCTCTACATGTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGAT
TATAGTCTCTCGCCACAGCGGCCTCGGCCTCCCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTG
GCACCTGAACTAAGTACTTTTATAGGCAACACCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGC
GGGGATTGCTAGTCTCACAGACCTCCTGAACCAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGC
ACGAATAGCAGAAGAGGTGAACTGCCTTTTGGCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAAC
AGATCACATAGAGTTGAAAGATAACCTTGGCAGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCC
TAATGTTTTCAGGGAGAAAAGCATGCAGAACAGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCA
CAGTAGTCCTGCATCTTCCAATTATCAACAAACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAA
CAGATTTATGCCACAGCAAAATAGCCCAGTGCCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAG
TTACACAACACATCCACAGATGCAACAAGCATCGGTATCAAGTCCCATTGTTGCAGGTGGTTTGAGAAACATACATGATAATAAAGTTTC
TGGTCCGTTGTCTGGCAATTCAGCTAATCATCATGCTGATAATCCTAGACATGGTTCAAGTGAGGACTACCTACACATGGTGCACAGGCT
AAGTAGTGACGATGGAGATTCTTCAACAATGAGGAATGCTGCATCTTTTCCCTTGAGATCTCCACAGCCAGTATGCTCCCCTGCTGGAAG
TGAAGGAACTCCTAAAGGTAAAGTGTTGAGAGAGGAGAACCAGTGCATTGCTCCTGTGGTTTCCAGCCGCGTGAGTCCAGGGACAAGACC
AACAGCTATGGGGTCTTTCAGCTCACACATGACAGAGTTTCCACGAAAACGCAAAGGAAGTGATTCAGACCCATCCCAAGAAGCTCATAG
CCAAACTGAAAAGCGGAGGAGAGATAAAATGAATAACCTGATTGAAGAACTGTCTGCAATGATCCCTCAGTGCAACCCCATGGCGCGTAA
ACTGGACAAACTTACAGTTTTAAGAATGGCTGTTCAACACTTGAGATCTTTAAAAGGCTTGACAAATTCTTATGTGGGAAGTAATTATAG
ACCATCATTTCTTCAGGATAATGAGCTCAGACATTTAATCCTTAAGACTGCAGAAGGCTTCTTATTTGTGGTTGGATGTGAAAGAGGAAA
AATTCTCTTCGTTTCTAAGTCAGTCTCCAAAATACTTAATTATGATCAGGCTAGTTTGACTGGACAAAGCTTATTTGACTTCTTACATCC
AAAAGATGTTGCCAAAGTAAAGGAACAACTTTCTTCTTTTGATATTTCACCAAGAGAAAAGCTAATAGATGCCAAAACTGGTTTGCAAGT
TCACAGTAATCTCCACGCTGGAAGGACACGTGTGTATTCTGGCTCAAGACGATCTTTTTTCTGTCGGATAAAGAGTTGTAAAATCTCTGT
CAAAGAAGAGCATGGATGCTTACCCAACTCAAAGAAGAAAGAGCACAGAAAATTCTATACTATCCATTGCACTGGTTACTTGAGAAGCTG
GCCTCCAAATATTGTTGGAATGGAAGAAGAAAGGAACAGTAAGAAAGACAACAGTAATTTTACCTGCCTTGTGGCCATTGGAAGATTACA
GCCATATATTGTTCCACAGAACAGTGGAGAGATTAATGTGAAACCAACTGAATTTATAACCCGGTTTGCAGTGAATGGAAAATTTGTCTA
TGTAGATCAAAGGGCAACAGCGATTTTAGGATATCTGCCTCAGGAACTTTTGGGAACTTCTTGTTATGAATATTTTCATCAAGATGACCA
CAATAATTTGACTGACAAGCACAAAGCAGTTCTACAGAGTAAGGAGAAAATACTTACAGATTCCTACAAATTCAGAGCAAAAGATGGCTC
TTTTGTAACTTTAAAAAGCCAATGGTTTAGTTTCACAAATCCTTGGACAAAAGAACTGGAATATATTGTATCTGTCAACACTTTAGTTTT
GGGACATAGTGAGCCTGGAGAAGCATCATTTTTACCTTGTAGCTCTCAATCATCAGAAGAATCCTCTAGACAGTCCTGTATGAGTGTACC
TGGAATGTCTACTGGAACAGTACTTGGTGCTGGTAGTATTGGAACAGATATTGCAAATGAAATTCTGGATTTACAGAGGTTACAGTCTTC
TTCATACCTTGATGATTCGAGTCCAACAGGTTTAATGAAAGATACTCATACTGTAAACTGCAGGAGTGTGATGGTGCACAGTTGGATTTC
GATGCCCTATGTGACAATGATGACACAGCCATGGCTGCATTTATGAATTACTTAGAAGCAGAGGGGGGCCTGGGAGACCCTGGGGACTTC

>59189_59189_6_NIPBL-ARNTL2_NIPBL_chr5_36972143_ENST00000282516_ARNTL2_chr12_27521195_ENST00000546179_length(amino acids)=808AA_BP=287
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASF
PLRSPQPVCSPAGSEGTPKGKVLREENQCIAPVVSSRVSPGTRPTAMGSFSSHMTEFPRKRKGSDSDPSQEAHSQTEKRRRDKMNNLIEE
LSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQ
ASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHR
KFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQEL
LGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTLVLGHSEPGEASFLPCSSQ

--------------------------------------------------------------
>59189_59189_7_NIPBL-ARNTL2_NIPBL_chr5_36972143_ENST00000448238_ARNTL2_chr12_27521195_ENST00000261178_length(transcript)=3130nt_BP=1336nt
ACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTCCGTCGGTACCGACTCACCCGACACCACCAAG
CCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCCCCCCCGGTAGCTCGGGCCCGTGGTCGGGTGT
TTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGTCTTCTCGGCTGGTCTCCCCCCGGCTCTACAT
GTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGATTATAGTCTCTCGCCACAGCGGCCTCGGCCTC
CCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTGGCACCTGAACTAAGTACTTTTATAGGCAACA
CCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGCGGGGATTGCTAGTCTCACAGACCTCCTGAAC
CAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGCACGAATAGCAGAAGAGGTGAACTGCCTTTTG
GCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAACAGATCACATAGAGTTGAAAGATAACCTTGGC
AGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCCTAATGTTTTCAGGGAGAAAAGCATGCAGAAC
AGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCACAGTAGTCCTGCATCTTCCAATTATCAACAA
ACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAACAGATTTATGCCACAGCAAAATAGCCCAGTG
CCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAGTTACACAACACATCCACAGATGCAACAAGCA
TCGGTATCAAGTCCCATTGTTGCAGGTGGTTTGAGAAACATACATGATAATAAAGTTTCTGGTCCGTTGTCTGGCAATTCAGCTAATCAT
CATGCTGATAATCCTAGACATGGTTCAAGTGAGGACTACCTACACATGGTGCACAGGCTAAGTAGTGACGATGGAGATTCTTCAACAATG
AGGAATGCTGCATCTTTTCCCTTGAGATCTCCACAGCCAGTATGCTCCCCTGCTGGAAGTGAAGGAACTCCTAAAGGTAAAGTGTTGAGA
GAGGAGAACCAGTGCATTGCTCCTGTGGTTTCCAGCCGCGTGAGTCCAGGGACAAGACCAACAGCTATGGGGTCTTTCAGCTCACACATG
ACAGAGTTTCCACGAAAACGCAAAGGAAGTGATTCAGACCCATCCCAAGAAGCTCATAGCCAAACTGAAAAGCGGAGGAGAGATAAAATG
AATAACCTGATTGAAGAACTGTCTGCAATGATCCCTCAGTGCAACCCCATGGCGCGTAAACTGGACAAACTTACAGTTTTAAGAATGGCT
GTTCAACACTTGAGATCTTTAAAAGGCTTGACAAATTCTTATGTGGGAAGTAATTATAGACCATCATTTCTTCAGGATAATGAGCTCAGA
CATTTAATCCTTAAGACTGCAGAAGGCTTCTTATTTGTGGTTGGATGTGAAAGAGGAAAAATTCTCTTCGTTTCTAAGTCAGTCTCCAAA
ATACTTAATTATGATCAGGCTAGTTTGACTGGACAAAGCTTATTTGACTTCTTACATCCAAAAGATGTTGCCAAAGTAAAGGAACAACTT
TCTTCTTTTGATATTTCACCAAGAGAAAAGCTAATAGATGCCAAAACTGGTTTGCAAGTTCACAGTAATCTCCACGCTGGAAGGACACGT
GTGTATTCTGGCTCAAGACGATCTTTTTTCTGTCGGATAAAGAGTTGTAAAATCTCTGTCAAAGAAGAGCATGGATGCTTACCCAACTCA
AAGAAGAAAGAGCACAGAAAATTCTATACTATCCATTGCACTGGTTACTTGAGAAGCTGGCCTCCAAATATTGTTGGAATGGAAGAAGAA
AGGAACAGTAAGAAAGACAACAGTAATTTTACCTGCCTTGTGGCCATTGGAAGATTACAGCCATATATTGTTCCACAGAACAGTGGAGAG
ATTAATGTGAAACCAACTGAATTTATAACCCGGTTTGCAGTGAATGGAAAATTTGTCTATGTAGATCAAAGGGCAACAGCGATTTTAGGA
TATCTGCCTCAGGAACTTTTGGGAACTTCTTGTTATGAATATTTTCATCAAGATGACCACAATAATTTGACTGACAAGCACAAAGCAGTT
CTACAGAGTAAGGAGAAAATACTTACAGATTCCTACAAATTCAGAGCAAAAGATGGCTCTTTTGTAACTTTAAAAAGCCAATGGTTTAGT
TTCACAAATCCTTGGACAAAAGAACTGGAATATATTGTATCTGTCAACACTTTAGTTTTGGGACATAGTGAGCCTGGAGAAGCATCATTT
TTACCTTGTAGCTCTCAATCATCAGAAGAATCCTCTAGACAGTCCTGTATGAGTGTACCTGGAATGTCTACTGGAACAGTACTTGGTGCT
GGTAGTATTGGAACAGATATTGCAAATGAAATTCTGGATTTACAGAGGTTACAGTCTTCTTCATACCTTGATGATTCGAGTCCAACAGGT
TTAATGAAAGATACTCATACTGTAAACTGCAGGAGTATGTCAAATAAGGAGTTGTTTCCACCAAGTCCTTCTGAAATGGGGGAGCTAGAG
GCTACCAGGCAAAACCAGAGTACTGTTGCTGTCCACAGCCATGAGCCACTCCTCAGTGATGGTGCACAGTTGGATTTCGATGCCCTATGT
GACAATGATGACACAGCCATGGCTGCATTTATGAATTACTTAGAAGCAGAGGGGGGCCTGGGAGACCCTGGGGACTTCAGTGACATCCAG

>59189_59189_7_NIPBL-ARNTL2_NIPBL_chr5_36972143_ENST00000448238_ARNTL2_chr12_27521195_ENST00000261178_length(amino acids)=867AA_BP=287
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASF
PLRSPQPVCSPAGSEGTPKGKVLREENQCIAPVVSSRVSPGTRPTAMGSFSSHMTEFPRKRKGSDSDPSQEAHSQTEKRRRDKMNNLIEE
LSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQ
ASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHR
KFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQEL
LGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTLVLGHSEPGEASFLPCSSQ
SSEESSRQSCMSVPGMSTGTVLGAGSIGTDIANEILDLQRLQSSSYLDDSSPTGLMKDTHTVNCRSMSNKELFPPSPSEMGELEATRQNQ

--------------------------------------------------------------
>59189_59189_8_NIPBL-ARNTL2_NIPBL_chr5_36972143_ENST00000448238_ARNTL2_chr12_27521195_ENST00000266503_length(transcript)=3578nt_BP=1336nt
ACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTCCGTCGGTACCGACTCACCCGACACCACCAAG
CCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCCCCCCCGGTAGCTCGGGCCCGTGGTCGGGTGT
TTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGTCTTCTCGGCTGGTCTCCCCCCGGCTCTACAT
GTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGATTATAGTCTCTCGCCACAGCGGCCTCGGCCTC
CCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTGGCACCTGAACTAAGTACTTTTATAGGCAACA
CCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGCGGGGATTGCTAGTCTCACAGACCTCCTGAAC
CAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGCACGAATAGCAGAAGAGGTGAACTGCCTTTTG
GCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAACAGATCACATAGAGTTGAAAGATAACCTTGGC
AGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCCTAATGTTTTCAGGGAGAAAAGCATGCAGAAC
AGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCACAGTAGTCCTGCATCTTCCAATTATCAACAA
ACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAACAGATTTATGCCACAGCAAAATAGCCCAGTG
CCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAGTTACACAACACATCCACAGATGCAACAAGCA
TCGGTATCAAGTCCCATTGTTGCAGGTGGTTTGAGAAACATACATGATAATAAAGTTTCTGGTCCGTTGTCTGGCAATTCAGCTAATCAT
CATGCTGATAATCCTAGACATGGTTCAAGTGAGGACTACCTACACATGGTGCACAGGCTAAGTAGTGACGATGGAGATTCTTCAACAATG
AGGAATGCTGCATCTTTTCCCTTGAGATCTCCACAGCCAGTATGCTCCCCTGCTGGAAGTGAAGGAACTCCTAAAGGTAAAGTGTTGAGA
GAGGAGAACCAGTGCATTGCTCCTGTGGTTTCCAGCCGCGTGAGTCCAGGGACAAGACCAACAGCTATGGGGTCTTTCAGCTCACACATG
ACAGAGTTTCCACGAAAACGCAAAGGAAGTGATTCAGACCCATCCCAGTCAGGAATCATGACAGAAAAAGTGGTGGAAAAGCTTTCTCAG
AATCCCCTTACCTATCTTCTTTCAACAAGGATAGAAATATCAGCCTCCAGTGGCAGCAGAGTGGAAGATGGTGAACACCAAGTTAAAATG
AAGGCCTTCAGAGAAGCTCATAGCCAAACTGAAAAGCGGAGGAGAGATAAAATGAATAACCTGATTGAAGAACTGTCTGCAATGATCCCT
CAGTGCAACCCCATGGCGCGTAAACTGGACAAACTTACAGTTTTAAGAATGGCTGTTCAACACTTGAGATCTTTAAAAGGCTTGACAAAT
TCTTATGTGGGAAGTAATTATAGACCATCATTTCTTCAGGATAATGAGCTCAGACATTTAATCCTTAAGACTGCAGAAGGCTTCTTATTT
GTGGTTGGATGTGAAAGAGGAAAAATTCTCTTCGTTTCTAAGTCAGTCTCCAAAATACTTAATTATGATCAGGCTAGTTTGACTGGACAA
AGCTTATTTGACTTCTTACATCCAAAAGATGTTGCCAAAGTAAAGGAACAACTTTCTTCTTTTGATATTTCACCAAGAGAAAAGCTAATA
GATGCCAAAACTGGTTTGCAAGTTCACAGTAATCTCCACGCTGGAAGGACACGTGTGTATTCTGGCTCAAGACGATCTTTTTTCTGTCGG
ATAAAGAGTTGTAAAATCTCTGTCAAAGAAGAGCATGGATGCTTACCCAACTCAAAGAAGAAAGAGCACAGAAAATTCTATACTATCCAT
TGCACTGGTTACTTGAGAAGCTGGCCTCCAAATATTGTTGGAATGGAAGAAGAAAGGAACAGTAAGAAAGACAACAGTAATTTTACCTGC
CTTGTGGCCATTGGAAGATTACAGCCATATATTGTTCCACAGAACAGTGGAGAGATTAATGTGAAACCAACTGAATTTATAACCCGGTTT
GCAGTGAATGGAAAATTTGTCTATGTAGATCAAAGGGCAACAGCGATTTTAGGATATCTGCCTCAGGAACTTTTGGGAACTTCTTGTTAT
GAATATTTTCATCAAGATGACCACAATAATTTGACTGACAAGCACAAAGCAGTTCTACAGAGTAAGGAGAAAATACTTACAGATTCCTAC
AAATTCAGAGCAAAAGATGGCTCTTTTGTAACTTTAAAAAGCCAATGGTTTAGTTTCACAAATCCTTGGACAAAAGAACTGGAATATATT
GTATCTGTCAACACTTTAGTTTTGGGACATAGTGAGCCTGGAGAAGCATCATTTTTACCTTGTAGCTCTCAATCATCAGAAGAATCCTCT
AGACAGTCCTGTATGAGTGTACCTGGAATGTCTACTGGAACAGTACTTGGTGCTGGTAGTATTGGAACAGATATTGCAAATGAAATTCTG
GATTTACAGAGGTTACAGTCTTCTTCATACCTTGATGATTCGAGTCCAACAGGTTTAATGAAAGATACTCATACTGTAAACTGCAGGAGT
ATGTCAAATAAGGAGTTGTTTCCACCAAGTCCTTCTGAAATGGGGGAGCTAGAGGCTACCAGGCAAAACCAGAGTACTGTTGCTGTCCAC
AGCCATGAGCCACTCCTCAGTGATGGTGCACAGTTGGATTTCGATGCCCTATGTGACAATGATGACACAGCCATGGCTGCATTTATGAAT
TACTTAGAAGCAGAGGGGGGCCTGGGAGACCCTGGGGACTTCAGTGACATCCAGTGGACCCTCTAGCCTTTGATTTTTAACTCCAAAAAT
GAGAAACATTTTAAAGCATTTCATTTACGAAAAACTGTCTCAACTATTCTTAAGTACTGTATTGATATTGTTTGTATCTTTTATTAATGT
TCTACCACTTTTTATAGATTTGCATCTTCCTGTCACAGGGATGTGGGGAAATACGTTTTCCTCCCAAGAGAACCAAGTTTATTATAGACT
CCTTTATTCAGTGAAATGGCTTATAATCCACTAGTTGCCATATTTTTGCTAAAATATTTCTAACCAAGAATACTACTTACATATTGTTTT

>59189_59189_8_NIPBL-ARNTL2_NIPBL_chr5_36972143_ENST00000448238_ARNTL2_chr12_27521195_ENST00000266503_length(amino acids)=915AA_BP=287
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASF
PLRSPQPVCSPAGSEGTPKGKVLREENQCIAPVVSSRVSPGTRPTAMGSFSSHMTEFPRKRKGSDSDPSQSGIMTEKVVEKLSQNPLTYL
LSTRIEISASSGSRVEDGEHQVKMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYVGSN
YRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGL
QVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGR
LQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKD
GSFVTLKSQWFSFTNPWTKELEYIVSVNTLVLGHSEPGEASFLPCSSQSSEESSRQSCMSVPGMSTGTVLGAGSIGTDIANEILDLQRLQ
SSSYLDDSSPTGLMKDTHTVNCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEG

--------------------------------------------------------------
>59189_59189_9_NIPBL-ARNTL2_NIPBL_chr5_36972143_ENST00000448238_ARNTL2_chr12_27521195_ENST00000311001_length(transcript)=3175nt_BP=1336nt
ACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTCCGTCGGTACCGACTCACCCGACACCACCAAG
CCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCCCCCCCGGTAGCTCGGGCCCGTGGTCGGGTGT
TTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGTCTTCTCGGCTGGTCTCCCCCCGGCTCTACAT
GTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGATTATAGTCTCTCGCCACAGCGGCCTCGGCCTC
CCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTGGCACCTGAACTAAGTACTTTTATAGGCAACA
CCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGCGGGGATTGCTAGTCTCACAGACCTCCTGAAC
CAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGCACGAATAGCAGAAGAGGTGAACTGCCTTTTG
GCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAACAGATCACATAGAGTTGAAAGATAACCTTGGC
AGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCCTAATGTTTTCAGGGAGAAAAGCATGCAGAAC
AGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCACAGTAGTCCTGCATCTTCCAATTATCAACAA
ACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAACAGATTTATGCCACAGCAAAATAGCCCAGTG
CCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAGTTACACAACACATCCACAGATGCAACAAGCA
TCGGTATCAAGTCCCATTGTTGCAGGTGGTTTGAGAAACATACATGATAATAAAGTTTCTGGTCCGTTGTCTGGCAATTCAGCTAATCAT
CATGCTGATAATCCTAGACATGGTTCAAGTGAGGACTACCTACACATGGTGCACAGGCTAAGTAGTGACGATGGAGATTCTTCAACAATG
AGGAATGCTGCATCTTTTCCCTTGAGATCTCCACAGCCAGTATGCTCCCCTGCTGGAAGTGAAGGAACTCCTAAAGGTAAAGTGTTGAGA
GAGGAGAACCAGTGCATTGCTCCTGTGGTTTCCAGCCGCGTGAGTCCAGGGACAAGACCAACAGCTATGGGGTCTTTCAGCTCACACATG
ACAGAGTTTCCACGAAAACGCAAAGGAAGTGATTCAGACCCATCCCAGTCAGGAATCATGACAGAAAAAGTGGTGGAAAAGCTTTCTCAG
AATCCCCTTACCTATCTTCTTTCAACAAGGATAGAAATATCAGCCTCCAGTGGCAGCAGAGAAGCTCATAGCCAAACTGAAAAGCGGAGG
AGAGATAAAATGAATAACCTGATTGAAGAACTGTCTGCAATGATCCCTCAGTGCAACCCCATGGCGCGTAAACTGGACAAACTTACAGTT
TTAAGAATGGCTGTTCAACACTTGAGATCTTTAAAAGGCTTGACAAATTCTTATGTGGGAAGTAATTATAGACCATCATTTCTTCAGGAT
AATGAGCTCAGACATTTAATCCTTAAGACTGCAGAAGGCTTCTTATTTGTGGTTGGATGTGAAAGAGGAAAAATTCTCTTCGTTTCTAAG
TCAGTCTCCAAAATACTTAATTATGATCAGGCTAGTTTGACTGGACAAAGCTTATTTGACTTCTTACATCCAAAAGATGTTGCCAAAGTA
AAGGAACAACTTTCTTCTTTTGATATTTCACCAAGAGAAAAGCTAATAGATGCCAAAACTGGTTTGCAAGTTCACAGTAATCTCCACGCT
GGAAGGACACGTGTGTATTCTGGCTCAAGACGATCTTTTTTCTGTCGGATAAAGAGTTGTAAAATCTCTGTCAAAGAAGAGCATGGATGC
TTACCCAACTCAAAGAAGAAAGAGCACAGAAAATTCTATACTATCCATTGCACTGGTTACTTGAGAAGCTGGCCTCCAAATATTGTTGGA
ATGGAAGAAGAAAGGAACAGTAAGAAAGACAACAGTAATTTTACCTGCCTTGTGGCCATTGGAAGATTACAGCCATATATTGTTCCACAG
AACAGTGGAGAGATTAATGTGAAACCAACTGAATTTATAACCCGGTTTGCAGTGAATGGAAAATTTGTCTATGTAGATCAAAGGGCAACA
GCGATTTTAGGATATCTGCCTCAGGAACTTTTGGGAACTTCTTGTTATGAATATTTTCATCAAGATGACCACAATAATTTGACTGACAAG
CACAAAGCAGTTCTACAGAGTAAGGAGAAAATACTTACAGATTCCTACAAATTCAGAGCAAAAGATGGCTCTTTTGTAACTTTAAAAAGC
CAATGGTTTAGTTTCACAAATCCTTGGACAAAAGAACTGGAATATATTGTATCTGTCAACACTTTAGTTTTGGGACATAGTGAGCCTGGA
GAAGCATCATTTTTACCTTGTAGCTCTCAATCATCAGAAGAATCCTCTAGACAGTCCTGTATGAGTGTACCTGGAATGTCTACTGGAACA
GTACTTGGTGCTGGTAGTATTGGAACAGATATTGCAAATGAAATTCTGGATTTACAGAGGTTACAGTCTTCTTCATACCTTGATGATTCG
AGTCCAACAGGTTTAATGAAAGATACTCATACTGTAAACTGCAGGAGTATGTCAAATAAGGAGTTGTTTCCACCAAGTCCTTCTGAAATG
GGGGAGCTAGAGGCTACCAGGCAAAACCAGAGTACTGTTGCTGTCCACAGCCATGAGCCACTCCTCAGTGATGGTGCACAGTTGGATTTC
GATGCCCTATGTGACAATGATGACACAGCCATGGCTGCATTTATGAATTACTTAGAAGCAGAGGGGGGCCTGGGAGACCCTGGGGACTTC

>59189_59189_9_NIPBL-ARNTL2_NIPBL_chr5_36972143_ENST00000448238_ARNTL2_chr12_27521195_ENST00000311001_length(amino acids)=901AA_BP=287
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASF
PLRSPQPVCSPAGSEGTPKGKVLREENQCIAPVVSSRVSPGTRPTAMGSFSSHMTEFPRKRKGSDSDPSQSGIMTEKVVEKLSQNPLTYL
LSTRIEISASSGSREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYVGSNYRPSFLQDNELRHL
ILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVY
SGSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEIN
VKPTEFITRFAVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFT
NPWTKELEYIVSVNTLVLGHSEPGEASFLPCSSQSSEESSRQSCMSVPGMSTGTVLGAGSIGTDIANEILDLQRLQSSSYLDDSSPTGLM
KDTHTVNCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWT

--------------------------------------------------------------
>59189_59189_10_NIPBL-ARNTL2_NIPBL_chr5_36972143_ENST00000448238_ARNTL2_chr12_27521195_ENST00000395901_length(transcript)=3073nt_BP=1336nt
ACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTCCGTCGGTACCGACTCACCCGACACCACCAAG
CCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCCCCCCCGGTAGCTCGGGCCCGTGGTCGGGTGT
TTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGTCTTCTCGGCTGGTCTCCCCCCGGCTCTACAT
GTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGATTATAGTCTCTCGCCACAGCGGCCTCGGCCTC
CCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTGGCACCTGAACTAAGTACTTTTATAGGCAACA
CCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGCGGGGATTGCTAGTCTCACAGACCTCCTGAAC
CAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGCACGAATAGCAGAAGAGGTGAACTGCCTTTTG
GCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAACAGATCACATAGAGTTGAAAGATAACCTTGGC
AGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCCTAATGTTTTCAGGGAGAAAAGCATGCAGAAC
AGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCACAGTAGTCCTGCATCTTCCAATTATCAACAA
ACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAACAGATTTATGCCACAGCAAAATAGCCCAGTG
CCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAGTTACACAACACATCCACAGATGCAACAAGCA
TCGGTATCAAGTCCCATTGTTGCAGGTGGTTTGAGAAACATACATGATAATAAAGTTTCTGGTCCGTTGTCTGGCAATTCAGCTAATCAT
CATGCTGATAATCCTAGACATGGTTCAAGTGAGGACTACCTACACATGGTGCACAGGCTAAGTAGTGACGATGGAGATTCTTCAACAATG
AGGAATGCTGCATCTTTTCCCTTGAGATCTCCACAGCCAGTATGCTCCCCTGCTGGAAGTGAAGGAACTCCTAAAGGTAAAGTGTTGAGA
GAGGAGAACCAGTGCATTGCTCCTGTGGTTTCCAGCCGCGTGAGTCCAGGGACAAGACCAACAGCTATGGGGTCTTTCAGCTCACACATG
ACAGAGTTTCCACGAAAACGCAAAGGAAGTGATTCAGACCCATCCCAAGAAGCTCATAGCCAAACTGAAAAGCGGAGGAGAGATAAAATG
AATAACCTGATTGAAGAACTGTCTGCAATGATCCCTCAGTGCAACCCCATGGCGCGTAAACTGGACAAACTTACAGTTTTAAGAATGGCT
GTTCAACACTTGAGATCTTTAAAAGGCTTGACAAATTCTTATGTGGGAAGTAATTATAGACCATCATTTCTTCAGGATAATGAGCTCAGA
CATTTAATCCTTAAGACTGCAGAAGGCTTCTTATTTGTGGTTGGATGTGAAAGAGGAAAAATTCTCTTCGTTTCTAAGTCAGTCTCCAAA
ATACTTAATTATGATCAGGCTAGTTTGACTGGACAAAGCTTATTTGACTTCTTACATCCAAAAGATGTTGCCAAAGTAAAGGAACAACTT
TCTTCTTTTGATATTTCACCAAGAGAAAAGCTAATAGATGCCAAAACTGGTTTGCAAGTTCACAGTAATCTCCACGCTGGAAGGACACGT
GTGTATTCTGGCTCAAGACGATCTTTTTTCTGTCGGATAAAGAGTTGTAAAATCTCTGTCAAAGAAGAGCATGGATGCTTACCCAACTCA
AAGAAGAAAGAGCACAGAAAATTCTATACTATCCATTGCACTGGTTACTTGAGAAGCTGGCCTCCAAATATTGTTGGAATGGAAGAAGAA
AGGAACAGTAAGAAAGACAACAGTAATTTTACCTGCCTTGTGGCCATTGGAAGATTACAGCCATATATTGTTCCACAGAACAGTGGAGAG
ATTAATGTGAAACCAACTGAATTTATAACCCGGTTTGCAGTGAATGGAAAATTTGTCTATGTAGATCAAAGGGCAACAGCGATTTTAGGA
TATCTGCCTCAGGAACTTTTGGGAACTTCTTGTTATGAATATTTTCATCAAGATGACCACAATAATTTGACTGACAAGCACAAAGCAGTT
CTACAGAGTAAGGAGAAAATACTTACAGATTCCTACAAATTCAGAGCAAAAGATGGCTCTTTTGTAACTTTAAAAAGCCAATGGTTTAGT
TTCACAAATCCTTGGACAAAAGAACTGGAATATATTGTATCTGTCAACACTTTAGTTTTGGGACATAGTGAGCCTGGAGAAGCATCATTT
TTACCTTGTAGCTCTCAATCATCAGAAGAATCCTCTAGACAGTCCTGTATGAGTGTACCTGGAATGTCTACTGGAACAGTACTTGGTGCT
GGTAGTATTGGAACAGATATTGCAAATGAAATTCTGGATTTACAGAGGTTACAGTCTTCTTCATACCTTGATGATTCGAGTCCAACAGGT
TTAATGAAAGATACTCATACTGTAAACTGCAGGAGTATGTCAAATAAGGAGTTGTTTCCACCAAGTCCTTCTGAAATGGGGGAGCTAGAG
GCTACCAGGCAAAACCAGAGTACTGTTGCTGTCCACAGCCATGAGCCACTCCTCAGTGATGGTGCACAGTTGGATTTCGATGCCCTATGT
GACAATGATGACACAGCCATGGCTGCATTTATGAATTACTTAGAAGCAGAGGGGGGCCTGGGAGACCCTGGGGACTTCAGTGACATCCAG

>59189_59189_10_NIPBL-ARNTL2_NIPBL_chr5_36972143_ENST00000448238_ARNTL2_chr12_27521195_ENST00000395901_length(amino acids)=867AA_BP=287
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASF
PLRSPQPVCSPAGSEGTPKGKVLREENQCIAPVVSSRVSPGTRPTAMGSFSSHMTEFPRKRKGSDSDPSQEAHSQTEKRRRDKMNNLIEE
LSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQ
ASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHR
KFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQEL
LGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTLVLGHSEPGEASFLPCSSQ
SSEESSRQSCMSVPGMSTGTVLGAGSIGTDIANEILDLQRLQSSSYLDDSSPTGLMKDTHTVNCRSMSNKELFPPSPSEMGELEATRQNQ

--------------------------------------------------------------
>59189_59189_11_NIPBL-ARNTL2_NIPBL_chr5_36972143_ENST00000448238_ARNTL2_chr12_27521195_ENST00000544915_length(transcript)=5890nt_BP=1336nt
ACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTCCGTCGGTACCGACTCACCCGACACCACCAAG
CCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCCCCCCCGGTAGCTCGGGCCCGTGGTCGGGTGT
TTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGTCTTCTCGGCTGGTCTCCCCCCGGCTCTACAT
GTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGATTATAGTCTCTCGCCACAGCGGCCTCGGCCTC
CCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTGGCACCTGAACTAAGTACTTTTATAGGCAACA
CCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGCGGGGATTGCTAGTCTCACAGACCTCCTGAAC
CAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGCACGAATAGCAGAAGAGGTGAACTGCCTTTTG
GCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAACAGATCACATAGAGTTGAAAGATAACCTTGGC
AGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCCTAATGTTTTCAGGGAGAAAAGCATGCAGAAC
AGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCACAGTAGTCCTGCATCTTCCAATTATCAACAA
ACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAACAGATTTATGCCACAGCAAAATAGCCCAGTG
CCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAGTTACACAACACATCCACAGATGCAACAAGCA
TCGGTATCAAGTCCCATTGTTGCAGGTGGTTTGAGAAACATACATGATAATAAAGTTTCTGGTCCGTTGTCTGGCAATTCAGCTAATCAT
CATGCTGATAATCCTAGACATGGTTCAAGTGAGGACTACCTACACATGGTGCACAGGCTAAGTAGTGACGATGGAGATTCTTCAACAATG
AGGAATGCTGCATCTTTTCCCTTGAGATCTCCACAGCCAGTATGCTCCCCTGCTGGAAGTGAAGGAACTCCTAAAGGTAAAGTGTTGAGA
GAGGAGAACCAGTGCATTGCTCCTGTGGTTTCCAGCCGCGTGAGTCCAGGGACAAGACCAACAGCTATGGGGTCTTTCAGCTCACACATG
ACAGAGTTTCCACGAAAACGCAAAGGAAGTGATTCAGACCCATCCCAAGTGGAAGATGGTGAACACCAAGTTAAAATGAAGGCCTTCAGA
GAAGCTCATAGCCAAACTGAAAAGCGGAGGAGAGATAAAATGAATAACCTGATTGAAGAACTGTCTGCAATGATCCCTCAGTGCAACCCC
ATGGCGCGTAAACTGGACAAACTTACAGTTTTAAGAATGGCTGTTCAACACTTGAGATCTTTAAAAGGCTTGACAAATTCTTATGTGGGA
AGTAATTATAGACCATCATTTCTTCAGGATAATGAGCTCAGACATTTAATCCTTAAGACTGCAGAAGGCTTCTTATTTGTGGTTGGATGT
GAAAGAGGAAAAATTCTCTTCGTTTCTAAGTCAGTCTCCAAAATACTTAATTATGATCAGGCTAGTTTGACTGGACAAAGCTTATTTGAC
TTCTTACATCCAAAAGATGTTGCCAAAGTAAAGGAACAACTTTCTTCTTTTGATATTTCACCAAGAGAAAAGCTAATAGATGCCAAAACT
GGTTTGCAAGTTCACAGTAATCTCCACGCTGGAAGGACACGTGTGTATTCTGGCTCAAGACGATCTTTTTTCTGTCGGATAAAGAGTTGT
AAAATCTCTGTCAAAGAAGAGCATGGATGCTTACCCAACTCAAAGAAGAAAGAGCACAGAAAATTCTATACTATCCATTGCACTGGTTAC
TTGAGAAGCTGGCCTCCAAATATTGTTGGAATGGAAGAAGAAAGGAACAGTAAGAAAGACAACAGTAATTTTACCTGCCTTGTGGCCATT
GGAAGATTACAGCCATATATTGTTCCACAGAACAGTGGAGAGATTAATGTGAAACCAACTGAATTTATAACCCGGTTTGCAGTGAATGGA
AAATTTGTCTATGTAGATCAAAGGGCAACAGCGATTTTAGGATATCTGCCTCAGGAACTTTTGGGAACTTCTTGTTATGAATATTTTCAT
CAAGATGACCACAATAATTTGACTGACAAGCACAAAGCAGTTCTACAGAGTAAGGAGAAAATACTTACAGATTCCTACAAATTCAGAGCA
AAAGATGGCTCTTTTGTAACTTTAAAAAGCCAATGGTTTAGTTTCACAAATCCTTGGACAAAAGAACTGGAATATATTGTATCTGTCAAC
ACTTTAGTTTTGGGACATAGTGAGCCTGGAGAAGCATCATTTTTACCTTGTAGCTCTCAATCATCAGAAGAATCCTCTAGACAGTCCTGT
ATGAGTGTACCTGGAATGTCTACTGGAACAGTACTTGGTGCTGGTAGTATTGGAACAGATATTGCAAATGAAATTCTGGATTTACAGAGG
TTACAGTCTTCTTCATACCTTGATGATTCGAGTCCAACAGGTTTAATGAAAGATACTCATACTGTAAACTGCAGGAGTATGTCAAATAAG
GAGTTGTTTCCACCAAGTCCTTCTGAAATGGGGGAGCTAGAGGCTACCAGGCAAAACCAGAGTACTGTTGCTGTCCACAGCCATGAGCCA
CTCCTCAGTGATGGTGCACAGTTGGATTTCGATGCCCTATGTGACAATGATGACACAGCCATGGCTGCATTTATGAATTACTTAGAAGCA
GAGGGGGGCCTGGGAGACCCTGGGGACTTCAGTGACATCCAGTGGACCCTCTAGCCTTTGATTTTTAACTCCAAAAATGAGAAACATTTT
AAAGCATTTCATTTACGAAAAACTGTCTCAACTATTCTTAAGTACTGTATTGATATTGTTTGTATCTTTTATTAATGTTCTACCACTTTT
TATAGATTTGCATCTTCCTGTCACAGGGATGTGGGGAAATACGTTTTCCTCCCAAGAGAACCAAGTTTATTATAGACTCCTTTATTCAGT
GAAATGGCTTATAATCCACTAGTTGCCATATTTTTGCTAAAATATTTCTAACCAAGAATACTACTTACATATTGTTTTGGCTTTGTTTTA
TTTTTGATGCAGTTTTTTTTAGTTGAGGTAATGTAATATATTGATGTTTTCCTTTGTGTCTAAGATTCATTTATAATAGTAGGTTTGTAT
AATTTGGAACATTTTCCATTCCTTGCGAATTTCCTTAATTGAGGATAGGGCTTACACACTTTAAGAAAACAGTGAGTACTTGAACATTTA
AAGGGACAGTGCAATTTATAGTCATAATCACATTGAATACTGTATTTGATCTTTGGAGACTTAGGCAAGCACAGAGCTGGGATATTTATG
CTCAGTTGAGCACTTTAAGATGAATTTTAAGTGAGATGATTTCTTGCTTAAAACTCAGAAAGTCAAAAGAGTTTCAGCTTTCCTTACAGA
AAAGGAAGGATCTTGGGCCCTAGATCTTGGGGATTAACCTCTGCATATAAGATTTACTCTTAATAGGCCAGACGTGGTGGCTCACGCCTG
TAATCCCAGTACTTTGGGAGGCTGAGACGGGCAGATCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAATATGGTGAAACCCCGTTT
CTACTAAAAATACAAAAAAAATTACCCAGGCACTCACTCTTGAGGTAACTAACCAACTCCCACGATAATGACAGTCCATTCATGAGCGCA
AAGGCCTCATGACCTAATGGCACACACCTGTAATCCCAACTGCTTGGGAGGCTGAGGCGAGAGGATTGCTTGAACCTGGGAGGCAGAGGT
TGCAGTGAGCCGAGATCGCACCACTGCACTCCAGTCTGGGCAACAGAGTGAGACTTCATCTCAAAAAAAGTAAAAAAAAAGATTTAATAT
AATCACTGAAGATCTCTATTATAGATAGATTAGGTTTTTGACATTGGAAACATACTTAGGGATAGATTTGTCCTAAAGGAAAAAAGTAGG
CCCGGGCAGATTAAATGTCTTGTGTAAAGTCACACATTAAATTCAGTCACACATTAAATTCATAGAGTTTTAAATGTTTAATGTATATAA
ACCAGTTTCTTTATACACATTTGGGAAAACATTGGTCTCACAGATTAAATGATTAACTAACTGACCCAGGAACTAGTTGTAGCTTTCTAA
GTAATTAGGCAATTACAGTTATTGCCTGTAACCAAAGGTAATAAAACAAAATGACAAGTACATGTTTAAAATTATGAGGCAATGAGAAAT
AATTTAAAAACCAATTTTCTAGTTATAATTTAAAATTTGGAGAGCATTTTTAACAGTAATTAATCCAGAGGTGGCTCAAATTGAGTATAA
GAATTAAGATTATTTAAAATACTGCATGTCTACCTTCTCGGGGATCATACTTTATAACACTTTCTGCTTCAGTAGCTCTTCATAGCTTGC
CAAGTATGCTCCCATATTTTCTCTCTCGTGCCTCGCAAATGAAAGTCAGATAGGCTGGGAACTCATGGGGCAGCCCTCAGACTTCAATGT
GGGCTTCAAATCCAGTTTCCTGTTCTATATGGTGCTACATCTTTCCAGAAAATTTCCCTCAGAGCCCCTCGCCAAAACAAAGCATTATTT
TGACCCTGCATGCTATTTCTTTAGCTGTAGGTGATAGATTAGAACTTCTGTCAGACATGTTAATGACAAACATACCAACAGACAATAACC
AAAAGCAAATGTTTCCTTCAAGTGTGAAATGTGCAGGGGCTTCGTGGGCAAGGATGTATTGGCACACTGTCCTCTTGAACTGATAGTGTC
CCAGCAATGTTGGAGGGTTGGCACCATTCCTGGTCCGACACTTGAGGACCTGAGAGACATCAGGTTTAGAATGAGCCAAAGAAATCCTAC
AAGATGGGGAGAATTGGTGTGCAGCAGCCTAAGTGTTATAGTTAAGTCTAAAGAAGTATGAAAGATCCCCTGTGTTCTCTAAATTGAGCA
GAGGGGCCTGCCTACCAATATCACTTTTTAGGGGACTGAACCATTGCAGGTTAGACTTGGCTTCCAAAGAGTCTGCCTAAGCCAGGGGTG
GCAGGGTAGGCCATCATAGCTGGATGGCCTCAAAAGCAGATGGGGGCAGACTTGCCCTCGTGATGCCAGGATTTGAGAGGCAGAGTTTCT
AGAGGGAGACCAGTGCTGCCTCTCACAGTGGCAGTTTTTTCTCTTTGCAAGAGGAGGGGCTGTTCAATTCCATAGACCAGTGGGCAGATA
GCCAGTTGAATACTCTGTGCATGGTTTGATCCTTTATTAGTTCGCTCTAATATTTTTCTGTAGATCCTTTTGTCCTGGACTCAAAATCTA
ATCCATGCATTGTATGATACCGTAGCTCTCCTAAGGTTTGTGTTTCCTTCAAAATGTTTTAGTTTTCTTCAACTAAATTTGATTTTTGCT
GTTAGAAGTGACATATTTTTATGGTATACACTATGTTCCTTTTTTCTACTGCGAGTCAATTTTTTGAATTTTCGTGAGAAAGAATATATC

>59189_59189_11_NIPBL-ARNTL2_NIPBL_chr5_36972143_ENST00000448238_ARNTL2_chr12_27521195_ENST00000544915_length(amino acids)=881AA_BP=287
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASF
PLRSPQPVCSPAGSEGTPKGKVLREENQCIAPVVSSRVSPGTRPTAMGSFSSHMTEFPRKRKGSDSDPSQVEDGEHQVKMKAFREAHSQT
EKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKIL
FVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKE
EHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVD
QRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTLVLGH
SEPGEASFLPCSSQSSEESSRQSCMSVPGMSTGTVLGAGSIGTDIANEILDLQRLQSSSYLDDSSPTGLMKDTHTVNCRSMSNKELFPPS

--------------------------------------------------------------
>59189_59189_12_NIPBL-ARNTL2_NIPBL_chr5_36972143_ENST00000448238_ARNTL2_chr12_27521195_ENST00000546179_length(transcript)=2980nt_BP=1336nt
ACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTCCGTCGGTACCGACTCACCCGACACCACCAAG
CCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCCCCCCCGGTAGCTCGGGCCCGTGGTCGGGTGT
TTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGTCTTCTCGGCTGGTCTCCCCCCGGCTCTACAT
GTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGATTATAGTCTCTCGCCACAGCGGCCTCGGCCTC
CCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTGGCACCTGAACTAAGTACTTTTATAGGCAACA
CCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGCGGGGATTGCTAGTCTCACAGACCTCCTGAAC
CAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGCACGAATAGCAGAAGAGGTGAACTGCCTTTTG
GCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAACAGATCACATAGAGTTGAAAGATAACCTTGGC
AGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCCTAATGTTTTCAGGGAGAAAAGCATGCAGAAC
AGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCACAGTAGTCCTGCATCTTCCAATTATCAACAA
ACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAACAGATTTATGCCACAGCAAAATAGCCCAGTG
CCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAGTTACACAACACATCCACAGATGCAACAAGCA
TCGGTATCAAGTCCCATTGTTGCAGGTGGTTTGAGAAACATACATGATAATAAAGTTTCTGGTCCGTTGTCTGGCAATTCAGCTAATCAT
CATGCTGATAATCCTAGACATGGTTCAAGTGAGGACTACCTACACATGGTGCACAGGCTAAGTAGTGACGATGGAGATTCTTCAACAATG
AGGAATGCTGCATCTTTTCCCTTGAGATCTCCACAGCCAGTATGCTCCCCTGCTGGAAGTGAAGGAACTCCTAAAGGTAAAGTGTTGAGA
GAGGAGAACCAGTGCATTGCTCCTGTGGTTTCCAGCCGCGTGAGTCCAGGGACAAGACCAACAGCTATGGGGTCTTTCAGCTCACACATG
ACAGAGTTTCCACGAAAACGCAAAGGAAGTGATTCAGACCCATCCCAAGAAGCTCATAGCCAAACTGAAAAGCGGAGGAGAGATAAAATG
AATAACCTGATTGAAGAACTGTCTGCAATGATCCCTCAGTGCAACCCCATGGCGCGTAAACTGGACAAACTTACAGTTTTAAGAATGGCT
GTTCAACACTTGAGATCTTTAAAAGGCTTGACAAATTCTTATGTGGGAAGTAATTATAGACCATCATTTCTTCAGGATAATGAGCTCAGA
CATTTAATCCTTAAGACTGCAGAAGGCTTCTTATTTGTGGTTGGATGTGAAAGAGGAAAAATTCTCTTCGTTTCTAAGTCAGTCTCCAAA
ATACTTAATTATGATCAGGCTAGTTTGACTGGACAAAGCTTATTTGACTTCTTACATCCAAAAGATGTTGCCAAAGTAAAGGAACAACTT
TCTTCTTTTGATATTTCACCAAGAGAAAAGCTAATAGATGCCAAAACTGGTTTGCAAGTTCACAGTAATCTCCACGCTGGAAGGACACGT
GTGTATTCTGGCTCAAGACGATCTTTTTTCTGTCGGATAAAGAGTTGTAAAATCTCTGTCAAAGAAGAGCATGGATGCTTACCCAACTCA
AAGAAGAAAGAGCACAGAAAATTCTATACTATCCATTGCACTGGTTACTTGAGAAGCTGGCCTCCAAATATTGTTGGAATGGAAGAAGAA
AGGAACAGTAAGAAAGACAACAGTAATTTTACCTGCCTTGTGGCCATTGGAAGATTACAGCCATATATTGTTCCACAGAACAGTGGAGAG
ATTAATGTGAAACCAACTGAATTTATAACCCGGTTTGCAGTGAATGGAAAATTTGTCTATGTAGATCAAAGGGCAACAGCGATTTTAGGA
TATCTGCCTCAGGAACTTTTGGGAACTTCTTGTTATGAATATTTTCATCAAGATGACCACAATAATTTGACTGACAAGCACAAAGCAGTT
CTACAGAGTAAGGAGAAAATACTTACAGATTCCTACAAATTCAGAGCAAAAGATGGCTCTTTTGTAACTTTAAAAAGCCAATGGTTTAGT
TTCACAAATCCTTGGACAAAAGAACTGGAATATATTGTATCTGTCAACACTTTAGTTTTGGGACATAGTGAGCCTGGAGAAGCATCATTT
TTACCTTGTAGCTCTCAATCATCAGAAGAATCCTCTAGACAGTCCTGTATGAGTGTACCTGGAATGTCTACTGGAACAGTACTTGGTGCT
GGTAGTATTGGAACAGATATTGCAAATGAAATTCTGGATTTACAGAGGTTACAGTCTTCTTCATACCTTGATGATTCGAGTCCAACAGGT
TTAATGAAAGATACTCATACTGTAAACTGCAGGAGTGTGATGGTGCACAGTTGGATTTCGATGCCCTATGTGACAATGATGACACAGCCA
TGGCTGCATTTATGAATTACTTAGAAGCAGAGGGGGGCCTGGGAGACCCTGGGGACTTCAGTGACATCCAGTGGACCCTCTAGCCTTTGA

>59189_59189_12_NIPBL-ARNTL2_NIPBL_chr5_36972143_ENST00000448238_ARNTL2_chr12_27521195_ENST00000546179_length(amino acids)=808AA_BP=287
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASF
PLRSPQPVCSPAGSEGTPKGKVLREENQCIAPVVSSRVSPGTRPTAMGSFSSHMTEFPRKRKGSDSDPSQEAHSQTEKRRRDKMNNLIEE
LSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQ
ASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHR
KFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQEL
LGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTLVLGHSEPGEASFLPCSSQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NIPBL-ARNTL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneARNTL2chr5:36972143chr12:27521195ENST0000026117801546_25810.333333333333334589.0PER2
TgeneARNTL2chr5:36972143chr12:27521195ENST0000026650301746_25810.333333333333334637.0PER2
TgeneARNTL2chr5:36972143chr12:27521195ENST0000031100101646_25810.333333333333334623.0PER2
TgeneARNTL2chr5:36972143chr12:27521195ENST0000039590101546_25821.333333333333332600.0PER2
TgeneARNTL2chr5:36972143chr12:27521195ENST0000054238801446_2580552.0PER2
TgeneARNTL2chr5:36972143chr12:27521195ENST0000054491501646_25810.333333333333334603.0PER2
TgeneARNTL2chr5:36972143chr12:27521195ENST0000054617901446_25821.333333333333332541.0PER2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NIPBL-ARNTL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NIPBL-ARNTL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource