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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NIPBL-C5orf42 (FusionGDB2 ID:59192)

Fusion Gene Summary for NIPBL-C5orf42

check button Fusion gene summary
Fusion gene informationFusion gene name: NIPBL-C5orf42
Fusion gene ID: 59192
HgeneTgene
Gene symbol

NIPBL

C5orf42

Gene ID

25836

65250

Gene nameNIPBL cohesin loading factorciliogenesis and planar polarity effector 1
SynonymsCDLS|CDLS1|IDN3|IDN3-B|Scc2C5orf42|Hug|JBTS17|OFD6
Cytomap

5p13.2

5p13.2

Type of geneprotein-codingprotein-coding
Descriptionnipped-B-like proteinNipped-B homologSCC2 homologdelanginsister chromatid cohesion 2 homologciliogenesis and planar polarity effector 1protein JBTS17transmembrane protein ENSP00000382582
Modification date2020031320200313
UniProtAcc

Q6KC79

.
Ensembl transtripts involved in fusion geneENST00000504430, ENST00000282516, 
ENST00000448238, 		ENST00000274258, 
ENST00000425232, ENST00000508244, 
ENST00000512288, 
Fusion gene scores* DoF score26 X 13 X 16=54087 X 8 X 5=280
# samples 437
** MAII scorelog2(43/5408*10)=-3.65268658669272
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/280*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NIPBL [Title/Abstract] AND C5orf42 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNIPBL(36962376)-C5orf42(37115151), # samples:4
C5orf42(37138821)-NIPBL(36995723), # samples:1
Anticipated loss of major functional domain due to fusion event.C5orf42-NIPBL seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
C5orf42-NIPBL seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNIPBL

GO:0000122

negative regulation of transcription by RNA polymerase II

18854353

HgeneNIPBL

GO:0031065

positive regulation of histone deacetylation

18854353

HgeneNIPBL

GO:0045892

negative regulation of transcription, DNA-templated

18854353

HgeneNIPBL

GO:0071921

cohesin loading

22628566


check buttonFusion gene breakpoints across NIPBL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across C5orf42 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A8NI-01ANIPBLchr5

36962376

-C5orf42chr5

37115151

-
ChimerDB4ESCATCGA-L5-A8NINIPBLchr5

36962376

+C5orf42chr5

37115151

-


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Fusion Gene ORF analysis for NIPBL-C5orf42

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000504430ENST00000274258NIPBLchr5

36962376

+C5orf42chr5

37115151

-
3UTR-3CDSENST00000504430ENST00000425232NIPBLchr5

36962376

+C5orf42chr5

37115151

-
3UTR-3CDSENST00000504430ENST00000508244NIPBLchr5

36962376

+C5orf42chr5

37115151

-
3UTR-intronENST00000504430ENST00000512288NIPBLchr5

36962376

+C5orf42chr5

37115151

-
5CDS-intronENST00000282516ENST00000512288NIPBLchr5

36962376

+C5orf42chr5

37115151

-
5CDS-intronENST00000448238ENST00000512288NIPBLchr5

36962376

+C5orf42chr5

37115151

-
In-frameENST00000282516ENST00000274258NIPBLchr5

36962376

+C5orf42chr5

37115151

-
In-frameENST00000282516ENST00000425232NIPBLchr5

36962376

+C5orf42chr5

37115151

-
In-frameENST00000282516ENST00000508244NIPBLchr5

36962376

+C5orf42chr5

37115151

-
In-frameENST00000448238ENST00000274258NIPBLchr5

36962376

+C5orf42chr5

37115151

-
In-frameENST00000448238ENST00000425232NIPBLchr5

36962376

+C5orf42chr5

37115151

-
In-frameENST00000448238ENST00000508244NIPBLchr5

36962376

+C5orf42chr5

37115151

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000282516NIPBLchr536962376+ENST00000508244C5orf42chr537115151-292911094991554351
ENST00000282516NIPBLchr536962376+ENST00000274258C5orf42chr537115151-292911094991554351
ENST00000282516NIPBLchr536962376+ENST00000425232C5orf42chr537115151-292911094991554351
ENST00000448238NIPBLchr536962376+ENST00000508244C5orf42chr537115151-289810784681523351
ENST00000448238NIPBLchr536962376+ENST00000274258C5orf42chr537115151-289810784681523351
ENST00000448238NIPBLchr536962376+ENST00000425232C5orf42chr537115151-289810784681523351

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000282516ENST00000508244NIPBLchr536962376+C5orf42chr537115151-0.0008608350.9991392
ENST00000282516ENST00000274258NIPBLchr536962376+C5orf42chr537115151-0.0008608350.9991392
ENST00000282516ENST00000425232NIPBLchr536962376+C5orf42chr537115151-0.0008608350.9991392
ENST00000448238ENST00000508244NIPBLchr536962376+C5orf42chr537115151-0.0008730120.999127
ENST00000448238ENST00000274258NIPBLchr536962376+C5orf42chr537115151-0.0008730120.999127
ENST00000448238ENST00000425232NIPBLchr536962376+C5orf42chr537115151-0.0008730120.999127

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Fusion Genomic Features for NIPBL-C5orf42


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NIPBL-C5orf42


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:36962376/chr5:37115151)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NIPBL

Q6KC79

.
FUNCTION: Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNIPBLchr5:36962376chr5:37115151ENST00000282516+647418_4622032805.0Compositional biasNote=Gln-rich
HgeneNIPBLchr5:36962376chr5:37115151ENST00000448238+646418_4622032698.0Compositional biasNote=Gln-rich
HgeneNIPBLchr5:36962376chr5:37115151ENST00000282516+647996_10092032805.0MotifPxVxL motif
HgeneNIPBLchr5:36962376chr5:37115151ENST00000448238+646996_10092032698.0MotifPxVxL motif
HgeneNIPBLchr5:36962376chr5:37115151ENST00000282516+6471767_18052032805.0RepeatNote=HEAT 1
HgeneNIPBLchr5:36962376chr5:37115151ENST00000282516+6471843_18812032805.0RepeatNote=HEAT 2
HgeneNIPBLchr5:36962376chr5:37115151ENST00000282516+6471945_19842032805.0RepeatNote=HEAT 3
HgeneNIPBLchr5:36962376chr5:37115151ENST00000282516+6472227_22672032805.0RepeatNote=HEAT 4
HgeneNIPBLchr5:36962376chr5:37115151ENST00000282516+6472313_23512032805.0RepeatNote=HEAT 5
HgeneNIPBLchr5:36962376chr5:37115151ENST00000448238+6461767_18052032698.0RepeatNote=HEAT 1
HgeneNIPBLchr5:36962376chr5:37115151ENST00000448238+6461843_18812032698.0RepeatNote=HEAT 2
HgeneNIPBLchr5:36962376chr5:37115151ENST00000448238+6461945_19842032698.0RepeatNote=HEAT 3
HgeneNIPBLchr5:36962376chr5:37115151ENST00000448238+6462227_22672032698.0RepeatNote=HEAT 4
HgeneNIPBLchr5:36962376chr5:37115151ENST00000448238+6462313_23512032698.0RepeatNote=HEAT 5
TgeneC5orf42chr5:36962376chr5:37115151ENST0000042523248522457_248730493198.0Coiled coilOntology_term=ECO:0000255
TgeneC5orf42chr5:36962376chr5:37115151ENST0000042523248522691_272430493198.0Coiled coilOntology_term=ECO:0000255
TgeneC5orf42chr5:36962376chr5:37115151ENST0000050824447512457_248730493198.0Coiled coilOntology_term=ECO:0000255
TgeneC5orf42chr5:36962376chr5:37115151ENST0000050824447512691_272430493198.0Coiled coilOntology_term=ECO:0000255
TgeneC5orf42chr5:36962376chr5:37115151ENST000004252324852592_61230493198.0TransmembraneHelical
TgeneC5orf42chr5:36962376chr5:37115151ENST000004252324852631_65130493198.0TransmembraneHelical
TgeneC5orf42chr5:36962376chr5:37115151ENST000005082444751592_61230493198.0TransmembraneHelical
TgeneC5orf42chr5:36962376chr5:37115151ENST000005082444751631_65130493198.0TransmembraneHelical


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Fusion Gene Sequence for NIPBL-C5orf42


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>59192_59192_1_NIPBL-C5orf42_NIPBL_chr5_36962376_ENST00000282516_C5orf42_chr5_37115151_ENST00000274258_length(transcript)=2929nt_BP=1109nt
TCCGGTCGGCATTTTGTTCTGAGAGGGAGAGACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTC
CGTCGGTACCGACTCACCCGACACCACCAAGCCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCC
CCCCCGGTAGCTCGGGCCCGTGGTCGGGTGTTTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGT
CTTCTCGGCTGGTCTCCCCCCGGCTCTACATGTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGAT
TATAGTCTCTCGCCACAGCGGCCTCGGCCTCCCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTG
GCACCTGAACTAAGTACTTTTATAGGCAACACCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGC
GGGGATTGCTAGTCTCACAGACCTCCTGAACCAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGC
ACGAATAGCAGAAGAGGTGAACTGCCTTTTGGCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAAC
AGATCACATAGAGTTGAAAGATAACCTTGGCAGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCC
TAATGTTTTCAGGGAGAAAAGCATGCAGAACAGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCA
CAGTAGTCCTGCATCTTCCAATTATCAACAAACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAA
CAGATTTATGCCACAGCAAAATAGCCCAGTGCCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAG
TTACACAACACATCCACAGATGCAACAAGGAACTGCCACTTTCACCATACAGAAAAAAGCTGGTGGAGCCAAAGCAGCAGTAAGAAAGGC
TACGCAGTCTCCAGTTACCTTCCAAAAAGGCTCTAATGCTCCGTGTCATAGTCTGCAGCATACAAAAAAACATGGAAGTGCTGGGCTTGC
ACCTCAAACCAAGCAGGTGTGTGTAGAGTATGAAAGAGAGGAGACTGTGGTGAGTCCCTGGACGATACCTTCAGAAATCCATAAGATTCT
TCATGAGAGTCACAATTCCCTTCTACAAGACTTGTCTCCAACTGAAGAGGAAGAGCCAGAGCATCCTTTTGGGGTGGGCGGTGTGGACAG
CGTGTCTGAGAGCACTGGCAGCATCCTCAGCAAGCTGGACTGGAATGCCATCGAAGACATGGTGGCCAGCGTGGAGGACCAGGGCCTGTC
TGTCCACTGGGCCCTGGACCTGTAAGACCTGGATATCATTGGGTTTCCATGCACAGGCCAGCACCTCAGTAATGTGGTTCTGAAAGATTA
ACAGGTTTAAGGGACAGAAGCAATGAAAGAAGCAATGTGAATTTTCCATTTGCTTTCATATTATTACCTGGATTAGCCATTACCAGAGGA
AAAATAAACATTTCTCAGTAACTTTGCCTTTATGGGGAAAGGGTTGACTATTGATGTATTATATGTTTTTGTATTTGATGCATCATTAGG
CATAATTTTTAAAATGATAAGTACCTTTCAAGCCAAGTTTGCATAACCTACTTTCAATAAAAACCCTCTATCTTGCCTCCTCCTTTATTA
CCCTCTGAGTTTTGAGAAACAACCATATACAGATGAATCTAATAGGAAAAAAAAAAATCTTTTCATTGAGAAGAAAATCAGTCTCACCTG
AGAACTCAATTATGAACCCTATTTTAAAACACCTATGCAGGGTTTAGCCTAGGAGTGAAAAGAAAAACCAACTACCTTTTACCAACCCTG
AATCTCTAAATAAGCAAAGTTTCATGGAGGCCAGGAGATCTTCTGTCTTCTGCCCTGTAGCCTGAAGCCTTGGAGGAAGAAACAGGAATG
GATGCTTTGGGCAGGAAAGTAAGGGAATATGACTCCGGCCTCTAGAAGGCTCATCTTAAATTTGTAAGAACCATGGTACAGAGACCTGAT
TAGTTTTTGGTATTGTGCTCCAATAATGTCATAGTTTTAAGAGATAATTTTTATGAGAATTGACTAAGAACCAGTATCCTTCAACTACTT
CATCAATGTTTGGTATAATATAAAAGCACACTATCATCTGAAAAAGCTATTAAATACCCCTCTTTTTCCAAATATCTACCTGTGTGAAGC
CAGGTTTTACAACATGTATTGCAGCAAGTTGAATGCAGAAGCAGGTATGGTAATTCAGCTGCCTTCTATCAAGCTAAACATTAAAGAGAT
TTGTAGAACTATAAAACAATGCTACTCTCCTTACCAAATTGTTTTAGAAAATAGCTTTATAGGCTAACATTATTGTTAATTGTCATTTAA
TTGTTTTGTCATTTAAAATATTTTAAATTGTTTTCTGTTAGTTTCTTTTTTGTATATTCTATGGGTATTTTATTGATACATGATAGTTGT
ACATTTTTATGGGGTGCATGTGATATTTTGATATGTGCATACAATGTGTAGCAATCAAATCAGGGTAATTGGGATATTCATCACCTCAAA
CATTTATCATTTATTTGTGTTGGAAACATTCAAACCTTTTCTTCTAGCTATTTATCCATTGTTGGATACTTATATCAATTCTATATCTTA

>59192_59192_1_NIPBL-C5orf42_NIPBL_chr5_36962376_ENST00000282516_C5orf42_chr5_37115151_ENST00000274258_length(amino acids)=351AA_BP=203
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQGTATFTIQKKAGGAKAAVRKATQSPVTFQKGSNAPCHSLQHTKKHGSAGLAPQTKQVCVEYEREETV

--------------------------------------------------------------
>59192_59192_2_NIPBL-C5orf42_NIPBL_chr5_36962376_ENST00000282516_C5orf42_chr5_37115151_ENST00000425232_length(transcript)=2929nt_BP=1109nt
TCCGGTCGGCATTTTGTTCTGAGAGGGAGAGACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTC
CGTCGGTACCGACTCACCCGACACCACCAAGCCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCC
CCCCCGGTAGCTCGGGCCCGTGGTCGGGTGTTTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGT
CTTCTCGGCTGGTCTCCCCCCGGCTCTACATGTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGAT
TATAGTCTCTCGCCACAGCGGCCTCGGCCTCCCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTG
GCACCTGAACTAAGTACTTTTATAGGCAACACCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGC
GGGGATTGCTAGTCTCACAGACCTCCTGAACCAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGC
ACGAATAGCAGAAGAGGTGAACTGCCTTTTGGCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAAC
AGATCACATAGAGTTGAAAGATAACCTTGGCAGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCC
TAATGTTTTCAGGGAGAAAAGCATGCAGAACAGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCA
CAGTAGTCCTGCATCTTCCAATTATCAACAAACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAA
CAGATTTATGCCACAGCAAAATAGCCCAGTGCCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAG
TTACACAACACATCCACAGATGCAACAAGGAACTGCCACTTTCACCATACAGAAAAAAGCTGGTGGAGCCAAAGCAGCAGTAAGAAAGGC
TACGCAGTCTCCAGTTACCTTCCAAAAAGGCTCTAATGCTCCGTGTCATAGTCTGCAGCATACAAAAAAACATGGAAGTGCTGGGCTTGC
ACCTCAAACCAAGCAGGTGTGTGTAGAGTATGAAAGAGAGGAGACTGTGGTGAGTCCCTGGACGATACCTTCAGAAATCCATAAGATTCT
TCATGAGAGTCACAATTCCCTTCTACAAGACTTGTCTCCAACTGAAGAGGAAGAGCCAGAGCATCCTTTTGGGGTGGGCGGTGTGGACAG
CGTGTCTGAGAGCACTGGCAGCATCCTCAGCAAGCTGGACTGGAATGCCATCGAAGACATGGTGGCCAGCGTGGAGGACCAGGGCCTGTC
TGTCCACTGGGCCCTGGACCTGTAAGACCTGGATATCATTGGGTTTCCATGCACAGGCCAGCACCTCAGTAATGTGGTTCTGAAAGATTA
ACAGGTTTAAGGGACAGAAGCAATGAAAGAAGCAATGTGAATTTTCCATTTGCTTTCATATTATTACCTGGATTAGCCATTACCAGAGGA
AAAATAAACATTTCTCAGTAACTTTGCCTTTATGGGGAAAGGGTTGACTATTGATGTATTATATGTTTTTGTATTTGATGCATCATTAGG
CATAATTTTTAAAATGATAAGTACCTTTCAAGCCAAGTTTGCATAACCTACTTTCAATAAAAACCCTCTATCTTGCCTCCTCCTTTATTA
CCCTCTGAGTTTTGAGAAACAACCATATACAGATGAATCTAATAGGAAAAAAAAAAATCTTTTCATTGAGAAGAAAATCAGTCTCACCTG
AGAACTCAATTATGAACCCTATTTTAAAACACCTATGCAGGGTTTAGCCTAGGAGTGAAAAGAAAAACCAACTACCTTTTACCAACCCTG
AATCTCTAAATAAGCAAAGTTTCATGGAGGCCAGGAGATCTTCTGTCTTCTGCCCTGTAGCCTGAAGCCTTGGAGGAAGAAACAGGAATG
GATGCTTTGGGCAGGAAAGTAAGGGAATATGACTCCGGCCTCTAGAAGGCTCATCTTAAATTTGTAAGAACCATGGTACAGAGACCTGAT
TAGTTTTTGGTATTGTGCTCCAATAATGTCATAGTTTTAAGAGATAATTTTTATGAGAATTGACTAAGAACCAGTATCCTTCAACTACTT
CATCAATGTTTGGTATAATATAAAAGCACACTATCATCTGAAAAAGCTATTAAATACCCCTCTTTTTCCAAATATCTACCTGTGTGAAGC
CAGGTTTTACAACATGTATTGCAGCAAGTTGAATGCAGAAGCAGGTATGGTAATTCAGCTGCCTTCTATCAAGCTAAACATTAAAGAGAT
TTGTAGAACTATAAAACAATGCTACTCTCCTTACCAAATTGTTTTAGAAAATAGCTTTATAGGCTAACATTATTGTTAATTGTCATTTAA
TTGTTTTGTCATTTAAAATATTTTAAATTGTTTTCTGTTAGTTTCTTTTTTGTATATTCTATGGGTATTTTATTGATACATGATAGTTGT
ACATTTTTATGGGGTGCATGTGATATTTTGATATGTGCATACAATGTGTAGCAATCAAATCAGGGTAATTGGGATATTCATCACCTCAAA
CATTTATCATTTATTTGTGTTGGAAACATTCAAACCTTTTCTTCTAGCTATTTATCCATTGTTGGATACTTATATCAATTCTATATCTTA

>59192_59192_2_NIPBL-C5orf42_NIPBL_chr5_36962376_ENST00000282516_C5orf42_chr5_37115151_ENST00000425232_length(amino acids)=351AA_BP=203
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQGTATFTIQKKAGGAKAAVRKATQSPVTFQKGSNAPCHSLQHTKKHGSAGLAPQTKQVCVEYEREETV

--------------------------------------------------------------
>59192_59192_3_NIPBL-C5orf42_NIPBL_chr5_36962376_ENST00000282516_C5orf42_chr5_37115151_ENST00000508244_length(transcript)=2929nt_BP=1109nt
TCCGGTCGGCATTTTGTTCTGAGAGGGAGAGACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTC
CGTCGGTACCGACTCACCCGACACCACCAAGCCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCC
CCCCCGGTAGCTCGGGCCCGTGGTCGGGTGTTTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGT
CTTCTCGGCTGGTCTCCCCCCGGCTCTACATGTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGAT
TATAGTCTCTCGCCACAGCGGCCTCGGCCTCCCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTG
GCACCTGAACTAAGTACTTTTATAGGCAACACCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGC
GGGGATTGCTAGTCTCACAGACCTCCTGAACCAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGC
ACGAATAGCAGAAGAGGTGAACTGCCTTTTGGCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAAC
AGATCACATAGAGTTGAAAGATAACCTTGGCAGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCC
TAATGTTTTCAGGGAGAAAAGCATGCAGAACAGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCA
CAGTAGTCCTGCATCTTCCAATTATCAACAAACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAA
CAGATTTATGCCACAGCAAAATAGCCCAGTGCCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAG
TTACACAACACATCCACAGATGCAACAAGGAACTGCCACTTTCACCATACAGAAAAAAGCTGGTGGAGCCAAAGCAGCAGTAAGAAAGGC
TACGCAGTCTCCAGTTACCTTCCAAAAAGGCTCTAATGCTCCGTGTCATAGTCTGCAGCATACAAAAAAACATGGAAGTGCTGGGCTTGC
ACCTCAAACCAAGCAGGTGTGTGTAGAGTATGAAAGAGAGGAGACTGTGGTGAGTCCCTGGACGATACCTTCAGAAATCCATAAGATTCT
TCATGAGAGTCACAATTCCCTTCTACAAGACTTGTCTCCAACTGAAGAGGAAGAGCCAGAGCATCCTTTTGGGGTGGGCGGTGTGGACAG
CGTGTCTGAGAGCACTGGCAGCATCCTCAGCAAGCTGGACTGGAATGCCATCGAAGACATGGTGGCCAGCGTGGAGGACCAGGGCCTGTC
TGTCCACTGGGCCCTGGACCTGTAAGACCTGGATATCATTGGGTTTCCATGCACAGGCCAGCACCTCAGTAATGTGGTTCTGAAAGATTA
ACAGGTTTAAGGGACAGAAGCAATGAAAGAAGCAATGTGAATTTTCCATTTGCTTTCATATTATTACCTGGATTAGCCATTACCAGAGGA
AAAATAAACATTTCTCAGTAACTTTGCCTTTATGGGGAAAGGGTTGACTATTGATGTATTATATGTTTTTGTATTTGATGCATCATTAGG
CATAATTTTTAAAATGATAAGTACCTTTCAAGCCAAGTTTGCATAACCTACTTTCAATAAAAACCCTCTATCTTGCCTCCTCCTTTATTA
CCCTCTGAGTTTTGAGAAACAACCATATACAGATGAATCTAATAGGAAAAAAAAAAATCTTTTCATTGAGAAGAAAATCAGTCTCACCTG
AGAACTCAATTATGAACCCTATTTTAAAACACCTATGCAGGGTTTAGCCTAGGAGTGAAAAGAAAAACCAACTACCTTTTACCAACCCTG
AATCTCTAAATAAGCAAAGTTTCATGGAGGCCAGGAGATCTTCTGTCTTCTGCCCTGTAGCCTGAAGCCTTGGAGGAAGAAACAGGAATG
GATGCTTTGGGCAGGAAAGTAAGGGAATATGACTCCGGCCTCTAGAAGGCTCATCTTAAATTTGTAAGAACCATGGTACAGAGACCTGAT
TAGTTTTTGGTATTGTGCTCCAATAATGTCATAGTTTTAAGAGATAATTTTTATGAGAATTGACTAAGAACCAGTATCCTTCAACTACTT
CATCAATGTTTGGTATAATATAAAAGCACACTATCATCTGAAAAAGCTATTAAATACCCCTCTTTTTCCAAATATCTACCTGTGTGAAGC
CAGGTTTTACAACATGTATTGCAGCAAGTTGAATGCAGAAGCAGGTATGGTAATTCAGCTGCCTTCTATCAAGCTAAACATTAAAGAGAT
TTGTAGAACTATAAAACAATGCTACTCTCCTTACCAAATTGTTTTAGAAAATAGCTTTATAGGCTAACATTATTGTTAATTGTCATTTAA
TTGTTTTGTCATTTAAAATATTTTAAATTGTTTTCTGTTAGTTTCTTTTTTGTATATTCTATGGGTATTTTATTGATACATGATAGTTGT
ACATTTTTATGGGGTGCATGTGATATTTTGATATGTGCATACAATGTGTAGCAATCAAATCAGGGTAATTGGGATATTCATCACCTCAAA
CATTTATCATTTATTTGTGTTGGAAACATTCAAACCTTTTCTTCTAGCTATTTATCCATTGTTGGATACTTATATCAATTCTATATCTTA

>59192_59192_3_NIPBL-C5orf42_NIPBL_chr5_36962376_ENST00000282516_C5orf42_chr5_37115151_ENST00000508244_length(amino acids)=351AA_BP=203
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQGTATFTIQKKAGGAKAAVRKATQSPVTFQKGSNAPCHSLQHTKKHGSAGLAPQTKQVCVEYEREETV

--------------------------------------------------------------
>59192_59192_4_NIPBL-C5orf42_NIPBL_chr5_36962376_ENST00000448238_C5orf42_chr5_37115151_ENST00000274258_length(transcript)=2898nt_BP=1078nt
ACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTCCGTCGGTACCGACTCACCCGACACCACCAAG
CCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCCCCCCCGGTAGCTCGGGCCCGTGGTCGGGTGT
TTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGTCTTCTCGGCTGGTCTCCCCCCGGCTCTACAT
GTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGATTATAGTCTCTCGCCACAGCGGCCTCGGCCTC
CCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTGGCACCTGAACTAAGTACTTTTATAGGCAACA
CCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGCGGGGATTGCTAGTCTCACAGACCTCCTGAAC
CAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGCACGAATAGCAGAAGAGGTGAACTGCCTTTTG
GCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAACAGATCACATAGAGTTGAAAGATAACCTTGGC
AGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCCTAATGTTTTCAGGGAGAAAAGCATGCAGAAC
AGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCACAGTAGTCCTGCATCTTCCAATTATCAACAA
ACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAACAGATTTATGCCACAGCAAAATAGCCCAGTG
CCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAGTTACACAACACATCCACAGATGCAACAAGGA
ACTGCCACTTTCACCATACAGAAAAAAGCTGGTGGAGCCAAAGCAGCAGTAAGAAAGGCTACGCAGTCTCCAGTTACCTTCCAAAAAGGC
TCTAATGCTCCGTGTCATAGTCTGCAGCATACAAAAAAACATGGAAGTGCTGGGCTTGCACCTCAAACCAAGCAGGTGTGTGTAGAGTAT
GAAAGAGAGGAGACTGTGGTGAGTCCCTGGACGATACCTTCAGAAATCCATAAGATTCTTCATGAGAGTCACAATTCCCTTCTACAAGAC
TTGTCTCCAACTGAAGAGGAAGAGCCAGAGCATCCTTTTGGGGTGGGCGGTGTGGACAGCGTGTCTGAGAGCACTGGCAGCATCCTCAGC
AAGCTGGACTGGAATGCCATCGAAGACATGGTGGCCAGCGTGGAGGACCAGGGCCTGTCTGTCCACTGGGCCCTGGACCTGTAAGACCTG
GATATCATTGGGTTTCCATGCACAGGCCAGCACCTCAGTAATGTGGTTCTGAAAGATTAACAGGTTTAAGGGACAGAAGCAATGAAAGAA
GCAATGTGAATTTTCCATTTGCTTTCATATTATTACCTGGATTAGCCATTACCAGAGGAAAAATAAACATTTCTCAGTAACTTTGCCTTT
ATGGGGAAAGGGTTGACTATTGATGTATTATATGTTTTTGTATTTGATGCATCATTAGGCATAATTTTTAAAATGATAAGTACCTTTCAA
GCCAAGTTTGCATAACCTACTTTCAATAAAAACCCTCTATCTTGCCTCCTCCTTTATTACCCTCTGAGTTTTGAGAAACAACCATATACA
GATGAATCTAATAGGAAAAAAAAAAATCTTTTCATTGAGAAGAAAATCAGTCTCACCTGAGAACTCAATTATGAACCCTATTTTAAAACA
CCTATGCAGGGTTTAGCCTAGGAGTGAAAAGAAAAACCAACTACCTTTTACCAACCCTGAATCTCTAAATAAGCAAAGTTTCATGGAGGC
CAGGAGATCTTCTGTCTTCTGCCCTGTAGCCTGAAGCCTTGGAGGAAGAAACAGGAATGGATGCTTTGGGCAGGAAAGTAAGGGAATATG
ACTCCGGCCTCTAGAAGGCTCATCTTAAATTTGTAAGAACCATGGTACAGAGACCTGATTAGTTTTTGGTATTGTGCTCCAATAATGTCA
TAGTTTTAAGAGATAATTTTTATGAGAATTGACTAAGAACCAGTATCCTTCAACTACTTCATCAATGTTTGGTATAATATAAAAGCACAC
TATCATCTGAAAAAGCTATTAAATACCCCTCTTTTTCCAAATATCTACCTGTGTGAAGCCAGGTTTTACAACATGTATTGCAGCAAGTTG
AATGCAGAAGCAGGTATGGTAATTCAGCTGCCTTCTATCAAGCTAAACATTAAAGAGATTTGTAGAACTATAAAACAATGCTACTCTCCT
TACCAAATTGTTTTAGAAAATAGCTTTATAGGCTAACATTATTGTTAATTGTCATTTAATTGTTTTGTCATTTAAAATATTTTAAATTGT
TTTCTGTTAGTTTCTTTTTTGTATATTCTATGGGTATTTTATTGATACATGATAGTTGTACATTTTTATGGGGTGCATGTGATATTTTGA
TATGTGCATACAATGTGTAGCAATCAAATCAGGGTAATTGGGATATTCATCACCTCAAACATTTATCATTTATTTGTGTTGGAAACATTC
AAACCTTTTCTTCTAGCTATTTATCCATTGTTGGATACTTATATCAATTCTATATCTTAGCTGTTGTGAATAGAGCTGCAATAAATGTAG

>59192_59192_4_NIPBL-C5orf42_NIPBL_chr5_36962376_ENST00000448238_C5orf42_chr5_37115151_ENST00000274258_length(amino acids)=351AA_BP=203
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQGTATFTIQKKAGGAKAAVRKATQSPVTFQKGSNAPCHSLQHTKKHGSAGLAPQTKQVCVEYEREETV

--------------------------------------------------------------
>59192_59192_5_NIPBL-C5orf42_NIPBL_chr5_36962376_ENST00000448238_C5orf42_chr5_37115151_ENST00000425232_length(transcript)=2898nt_BP=1078nt
ACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTCCGTCGGTACCGACTCACCCGACACCACCAAG
CCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCCCCCCCGGTAGCTCGGGCCCGTGGTCGGGTGT
TTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGTCTTCTCGGCTGGTCTCCCCCCGGCTCTACAT
GTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGATTATAGTCTCTCGCCACAGCGGCCTCGGCCTC
CCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTGGCACCTGAACTAAGTACTTTTATAGGCAACA
CCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGCGGGGATTGCTAGTCTCACAGACCTCCTGAAC
CAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGCACGAATAGCAGAAGAGGTGAACTGCCTTTTG
GCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAACAGATCACATAGAGTTGAAAGATAACCTTGGC
AGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCCTAATGTTTTCAGGGAGAAAAGCATGCAGAAC
AGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCACAGTAGTCCTGCATCTTCCAATTATCAACAA
ACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAACAGATTTATGCCACAGCAAAATAGCCCAGTG
CCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAGTTACACAACACATCCACAGATGCAACAAGGA
ACTGCCACTTTCACCATACAGAAAAAAGCTGGTGGAGCCAAAGCAGCAGTAAGAAAGGCTACGCAGTCTCCAGTTACCTTCCAAAAAGGC
TCTAATGCTCCGTGTCATAGTCTGCAGCATACAAAAAAACATGGAAGTGCTGGGCTTGCACCTCAAACCAAGCAGGTGTGTGTAGAGTAT
GAAAGAGAGGAGACTGTGGTGAGTCCCTGGACGATACCTTCAGAAATCCATAAGATTCTTCATGAGAGTCACAATTCCCTTCTACAAGAC
TTGTCTCCAACTGAAGAGGAAGAGCCAGAGCATCCTTTTGGGGTGGGCGGTGTGGACAGCGTGTCTGAGAGCACTGGCAGCATCCTCAGC
AAGCTGGACTGGAATGCCATCGAAGACATGGTGGCCAGCGTGGAGGACCAGGGCCTGTCTGTCCACTGGGCCCTGGACCTGTAAGACCTG
GATATCATTGGGTTTCCATGCACAGGCCAGCACCTCAGTAATGTGGTTCTGAAAGATTAACAGGTTTAAGGGACAGAAGCAATGAAAGAA
GCAATGTGAATTTTCCATTTGCTTTCATATTATTACCTGGATTAGCCATTACCAGAGGAAAAATAAACATTTCTCAGTAACTTTGCCTTT
ATGGGGAAAGGGTTGACTATTGATGTATTATATGTTTTTGTATTTGATGCATCATTAGGCATAATTTTTAAAATGATAAGTACCTTTCAA
GCCAAGTTTGCATAACCTACTTTCAATAAAAACCCTCTATCTTGCCTCCTCCTTTATTACCCTCTGAGTTTTGAGAAACAACCATATACA
GATGAATCTAATAGGAAAAAAAAAAATCTTTTCATTGAGAAGAAAATCAGTCTCACCTGAGAACTCAATTATGAACCCTATTTTAAAACA
CCTATGCAGGGTTTAGCCTAGGAGTGAAAAGAAAAACCAACTACCTTTTACCAACCCTGAATCTCTAAATAAGCAAAGTTTCATGGAGGC
CAGGAGATCTTCTGTCTTCTGCCCTGTAGCCTGAAGCCTTGGAGGAAGAAACAGGAATGGATGCTTTGGGCAGGAAAGTAAGGGAATATG
ACTCCGGCCTCTAGAAGGCTCATCTTAAATTTGTAAGAACCATGGTACAGAGACCTGATTAGTTTTTGGTATTGTGCTCCAATAATGTCA
TAGTTTTAAGAGATAATTTTTATGAGAATTGACTAAGAACCAGTATCCTTCAACTACTTCATCAATGTTTGGTATAATATAAAAGCACAC
TATCATCTGAAAAAGCTATTAAATACCCCTCTTTTTCCAAATATCTACCTGTGTGAAGCCAGGTTTTACAACATGTATTGCAGCAAGTTG
AATGCAGAAGCAGGTATGGTAATTCAGCTGCCTTCTATCAAGCTAAACATTAAAGAGATTTGTAGAACTATAAAACAATGCTACTCTCCT
TACCAAATTGTTTTAGAAAATAGCTTTATAGGCTAACATTATTGTTAATTGTCATTTAATTGTTTTGTCATTTAAAATATTTTAAATTGT
TTTCTGTTAGTTTCTTTTTTGTATATTCTATGGGTATTTTATTGATACATGATAGTTGTACATTTTTATGGGGTGCATGTGATATTTTGA
TATGTGCATACAATGTGTAGCAATCAAATCAGGGTAATTGGGATATTCATCACCTCAAACATTTATCATTTATTTGTGTTGGAAACATTC
AAACCTTTTCTTCTAGCTATTTATCCATTGTTGGATACTTATATCAATTCTATATCTTAGCTGTTGTGAATAGAGCTGCAATAAATGTAG

>59192_59192_5_NIPBL-C5orf42_NIPBL_chr5_36962376_ENST00000448238_C5orf42_chr5_37115151_ENST00000425232_length(amino acids)=351AA_BP=203
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQGTATFTIQKKAGGAKAAVRKATQSPVTFQKGSNAPCHSLQHTKKHGSAGLAPQTKQVCVEYEREETV

--------------------------------------------------------------
>59192_59192_6_NIPBL-C5orf42_NIPBL_chr5_36962376_ENST00000448238_C5orf42_chr5_37115151_ENST00000508244_length(transcript)=2898nt_BP=1078nt
ACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTCCGTCGGTACCGACTCACCCGACACCACCAAG
CCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCCCCCCCGGTAGCTCGGGCCCGTGGTCGGGTGT
TTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGTCTTCTCGGCTGGTCTCCCCCCGGCTCTACAT
GTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGATTATAGTCTCTCGCCACAGCGGCCTCGGCCTC
CCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTGGCACCTGAACTAAGTACTTTTATAGGCAACA
CCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGCGGGGATTGCTAGTCTCACAGACCTCCTGAAC
CAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGCACGAATAGCAGAAGAGGTGAACTGCCTTTTG
GCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAACAGATCACATAGAGTTGAAAGATAACCTTGGC
AGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCCTAATGTTTTCAGGGAGAAAAGCATGCAGAAC
AGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCACAGTAGTCCTGCATCTTCCAATTATCAACAA
ACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAACAGATTTATGCCACAGCAAAATAGCCCAGTG
CCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAGTTACACAACACATCCACAGATGCAACAAGGA
ACTGCCACTTTCACCATACAGAAAAAAGCTGGTGGAGCCAAAGCAGCAGTAAGAAAGGCTACGCAGTCTCCAGTTACCTTCCAAAAAGGC
TCTAATGCTCCGTGTCATAGTCTGCAGCATACAAAAAAACATGGAAGTGCTGGGCTTGCACCTCAAACCAAGCAGGTGTGTGTAGAGTAT
GAAAGAGAGGAGACTGTGGTGAGTCCCTGGACGATACCTTCAGAAATCCATAAGATTCTTCATGAGAGTCACAATTCCCTTCTACAAGAC
TTGTCTCCAACTGAAGAGGAAGAGCCAGAGCATCCTTTTGGGGTGGGCGGTGTGGACAGCGTGTCTGAGAGCACTGGCAGCATCCTCAGC
AAGCTGGACTGGAATGCCATCGAAGACATGGTGGCCAGCGTGGAGGACCAGGGCCTGTCTGTCCACTGGGCCCTGGACCTGTAAGACCTG
GATATCATTGGGTTTCCATGCACAGGCCAGCACCTCAGTAATGTGGTTCTGAAAGATTAACAGGTTTAAGGGACAGAAGCAATGAAAGAA
GCAATGTGAATTTTCCATTTGCTTTCATATTATTACCTGGATTAGCCATTACCAGAGGAAAAATAAACATTTCTCAGTAACTTTGCCTTT
ATGGGGAAAGGGTTGACTATTGATGTATTATATGTTTTTGTATTTGATGCATCATTAGGCATAATTTTTAAAATGATAAGTACCTTTCAA
GCCAAGTTTGCATAACCTACTTTCAATAAAAACCCTCTATCTTGCCTCCTCCTTTATTACCCTCTGAGTTTTGAGAAACAACCATATACA
GATGAATCTAATAGGAAAAAAAAAAATCTTTTCATTGAGAAGAAAATCAGTCTCACCTGAGAACTCAATTATGAACCCTATTTTAAAACA
CCTATGCAGGGTTTAGCCTAGGAGTGAAAAGAAAAACCAACTACCTTTTACCAACCCTGAATCTCTAAATAAGCAAAGTTTCATGGAGGC
CAGGAGATCTTCTGTCTTCTGCCCTGTAGCCTGAAGCCTTGGAGGAAGAAACAGGAATGGATGCTTTGGGCAGGAAAGTAAGGGAATATG
ACTCCGGCCTCTAGAAGGCTCATCTTAAATTTGTAAGAACCATGGTACAGAGACCTGATTAGTTTTTGGTATTGTGCTCCAATAATGTCA
TAGTTTTAAGAGATAATTTTTATGAGAATTGACTAAGAACCAGTATCCTTCAACTACTTCATCAATGTTTGGTATAATATAAAAGCACAC
TATCATCTGAAAAAGCTATTAAATACCCCTCTTTTTCCAAATATCTACCTGTGTGAAGCCAGGTTTTACAACATGTATTGCAGCAAGTTG
AATGCAGAAGCAGGTATGGTAATTCAGCTGCCTTCTATCAAGCTAAACATTAAAGAGATTTGTAGAACTATAAAACAATGCTACTCTCCT
TACCAAATTGTTTTAGAAAATAGCTTTATAGGCTAACATTATTGTTAATTGTCATTTAATTGTTTTGTCATTTAAAATATTTTAAATTGT
TTTCTGTTAGTTTCTTTTTTGTATATTCTATGGGTATTTTATTGATACATGATAGTTGTACATTTTTATGGGGTGCATGTGATATTTTGA
TATGTGCATACAATGTGTAGCAATCAAATCAGGGTAATTGGGATATTCATCACCTCAAACATTTATCATTTATTTGTGTTGGAAACATTC
AAACCTTTTCTTCTAGCTATTTATCCATTGTTGGATACTTATATCAATTCTATATCTTAGCTGTTGTGAATAGAGCTGCAATAAATGTAG

>59192_59192_6_NIPBL-C5orf42_NIPBL_chr5_36962376_ENST00000448238_C5orf42_chr5_37115151_ENST00000508244_length(amino acids)=351AA_BP=203
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQGTATFTIQKKAGGAKAAVRKATQSPVTFQKGSNAPCHSLQHTKKHGSAGLAPQTKQVCVEYEREETV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NIPBL-C5orf42


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NIPBL-C5orf42


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NIPBL-C5orf42


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource