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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NIPBL-MYO10 (FusionGDB2 ID:59206)

Fusion Gene Summary for NIPBL-MYO10

check button Fusion gene summary
Fusion gene informationFusion gene name: NIPBL-MYO10
Fusion gene ID: 59206
HgeneTgene
Gene symbol

NIPBL

MYO10

Gene ID

25836

4651

Gene nameNIPBL cohesin loading factormyosin X
SynonymsCDLS|CDLS1|IDN3|IDN3-B|Scc2-
Cytomap

5p13.2

5p15.1

Type of geneprotein-codingprotein-coding
Descriptionnipped-B-like proteinNipped-B homologSCC2 homologdelanginsister chromatid cohesion 2 homologunconventional myosin-Xunconventional myosin-10unconventionnal myosin-X
Modification date2020031320200313
UniProtAcc

Q6KC79

Q9HD67

Ensembl transtripts involved in fusion geneENST00000282516, ENST00000448238, 
ENST00000504430, 		ENST00000274203, 
ENST00000427430, ENST00000505695, 
ENST00000512061, ENST00000515803, 
ENST00000507288, ENST00000513610, 
Fusion gene scores* DoF score26 X 13 X 16=54089 X 11 X 4=396
# samples 4311
** MAII scorelog2(43/5408*10)=-3.65268658669272
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/396*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NIPBL [Title/Abstract] AND MYO10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNIPBL(37010327)-MYO10(16877816), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNIPBL

GO:0000122

negative regulation of transcription by RNA polymerase II

18854353

HgeneNIPBL

GO:0031065

positive regulation of histone deacetylation

18854353

HgeneNIPBL

GO:0045892

negative regulation of transcription, DNA-templated

18854353

HgeneNIPBL

GO:0071921

cohesin loading

22628566


check buttonFusion gene breakpoints across NIPBL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MYO10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-05-4426-01ANIPBLchr5

37010327

-MYO10chr5

16877816

-
ChimerDB4LUADTCGA-05-4426-01ANIPBLchr5

37010327

+MYO10chr5

16877816

-


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Fusion Gene ORF analysis for NIPBL-MYO10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000282516ENST00000274203NIPBLchr5

37010327

+MYO10chr5

16877816

-
5CDS-intronENST00000282516ENST00000427430NIPBLchr5

37010327

+MYO10chr5

16877816

-
5CDS-intronENST00000282516ENST00000505695NIPBLchr5

37010327

+MYO10chr5

16877816

-
5CDS-intronENST00000282516ENST00000512061NIPBLchr5

37010327

+MYO10chr5

16877816

-
5CDS-intronENST00000282516ENST00000515803NIPBLchr5

37010327

+MYO10chr5

16877816

-
5CDS-intronENST00000448238ENST00000274203NIPBLchr5

37010327

+MYO10chr5

16877816

-
5CDS-intronENST00000448238ENST00000427430NIPBLchr5

37010327

+MYO10chr5

16877816

-
5CDS-intronENST00000448238ENST00000505695NIPBLchr5

37010327

+MYO10chr5

16877816

-
5CDS-intronENST00000448238ENST00000512061NIPBLchr5

37010327

+MYO10chr5

16877816

-
5CDS-intronENST00000448238ENST00000515803NIPBLchr5

37010327

+MYO10chr5

16877816

-
In-frameENST00000282516ENST00000507288NIPBLchr5

37010327

+MYO10chr5

16877816

-
In-frameENST00000282516ENST00000513610NIPBLchr5

37010327

+MYO10chr5

16877816

-
In-frameENST00000448238ENST00000507288NIPBLchr5

37010327

+MYO10chr5

16877816

-
In-frameENST00000448238ENST00000513610NIPBLchr5

37010327

+MYO10chr5

16877816

-
intron-3CDSENST00000504430ENST00000507288NIPBLchr5

37010327

+MYO10chr5

16877816

-
intron-3CDSENST00000504430ENST00000513610NIPBLchr5

37010327

+MYO10chr5

16877816

-
intron-intronENST00000504430ENST00000274203NIPBLchr5

37010327

+MYO10chr5

16877816

-
intron-intronENST00000504430ENST00000427430NIPBLchr5

37010327

+MYO10chr5

16877816

-
intron-intronENST00000504430ENST00000505695NIPBLchr5

37010327

+MYO10chr5

16877816

-
intron-intronENST00000504430ENST00000512061NIPBLchr5

37010327

+MYO10chr5

16877816

-
intron-intronENST00000504430ENST00000515803NIPBLchr5

37010327

+MYO10chr5

16877816

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000282516NIPBLchr537010327+ENST00000513610MYO10chr516877816-126215059499112143571
ENST00000282516NIPBLchr537010327+ENST00000507288MYO10chr516877816-6264505949953311610
ENST00000448238NIPBLchr537010327+ENST00000513610MYO10chr516877816-125905028468111833571
ENST00000448238NIPBLchr537010327+ENST00000507288MYO10chr516877816-6233502846853001610

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000282516ENST00000513610NIPBLchr537010327+MYO10chr516877816-0.0008924940.99910754
ENST00000282516ENST00000507288NIPBLchr537010327+MYO10chr516877816-0.0006203970.99937963
ENST00000448238ENST00000513610NIPBLchr537010327+MYO10chr516877816-0.0008764460.9991235
ENST00000448238ENST00000507288NIPBLchr537010327+MYO10chr516877816-0.0006159350.99938405

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Fusion Genomic Features for NIPBL-MYO10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NIPBL-MYO10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:37010327/chr5:16877816)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NIPBL

Q6KC79

MYO10

Q9HD67

FUNCTION: Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}.FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts. {ECO:0000269|PubMed:16894163, ECO:0000269|PubMed:18570893}.; FUNCTION: [Isoform Headless]: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNIPBLchr5:37010327chr5:16877816ENST00000282516+2147418_46215202805.0Compositional biasNote=Gln-rich
HgeneNIPBLchr5:37010327chr5:16877816ENST00000448238+2146418_46215202698.0Compositional biasNote=Gln-rich
HgeneNIPBLchr5:37010327chr5:16877816ENST00000282516+2147996_100915202805.0MotifPxVxL motif
HgeneNIPBLchr5:37010327chr5:16877816ENST00000448238+2146996_100915202698.0MotifPxVxL motif
TgeneMYO10chr5:37010327chr5:16877816ENST000005136100411212_131072059.0DomainPH 1
TgeneMYO10chr5:37010327chr5:16877816ENST000005136100411392_149772059.0DomainPH 2
TgeneMYO10chr5:37010327chr5:16877816ENST000005136100411547_169572059.0DomainMyTH4
TgeneMYO10chr5:37010327chr5:16877816ENST000005136100411700_204472059.0DomainFERM
TgeneMYO10chr5:37010327chr5:16877816ENST0000051361004163_73972059.0DomainMyosin motor
TgeneMYO10chr5:37010327chr5:16877816ENST00000513610041742_76372059.0DomainIQ 1
TgeneMYO10chr5:37010327chr5:16877816ENST00000513610041764_78772059.0DomainIQ 2
TgeneMYO10chr5:37010327chr5:16877816ENST00000513610041788_81772059.0DomainIQ 3
TgeneMYO10chr5:37010327chr5:16877816ENST00000513610041157_16472059.0Nucleotide bindingATP
TgeneMYO10chr5:37010327chr5:16877816ENST00000513610041619_64172059.0RegionActin-binding
TgeneMYO10chr5:37010327chr5:16877816ENST00000513610041815_90872059.0RegionSAH
TgeneMYO10chr5:37010327chr5:16877816ENST00000513610041883_93372059.0RegionMediates antiparallel dimerization

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNIPBLchr5:37010327chr5:16877816ENST00000282516+21471767_180515202805.0RepeatNote=HEAT 1
HgeneNIPBLchr5:37010327chr5:16877816ENST00000282516+21471843_188115202805.0RepeatNote=HEAT 2
HgeneNIPBLchr5:37010327chr5:16877816ENST00000282516+21471945_198415202805.0RepeatNote=HEAT 3
HgeneNIPBLchr5:37010327chr5:16877816ENST00000282516+21472227_226715202805.0RepeatNote=HEAT 4
HgeneNIPBLchr5:37010327chr5:16877816ENST00000282516+21472313_235115202805.0RepeatNote=HEAT 5
HgeneNIPBLchr5:37010327chr5:16877816ENST00000448238+21461767_180515202698.0RepeatNote=HEAT 1
HgeneNIPBLchr5:37010327chr5:16877816ENST00000448238+21461843_188115202698.0RepeatNote=HEAT 2
HgeneNIPBLchr5:37010327chr5:16877816ENST00000448238+21461945_198415202698.0RepeatNote=HEAT 3
HgeneNIPBLchr5:37010327chr5:16877816ENST00000448238+21462227_226715202698.0RepeatNote=HEAT 4
HgeneNIPBLchr5:37010327chr5:16877816ENST00000448238+21462313_235115202698.0RepeatNote=HEAT 5


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Fusion Gene Sequence for NIPBL-MYO10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>59206_59206_1_NIPBL-MYO10_NIPBL_chr5_37010327_ENST00000282516_MYO10_chr5_16877816_ENST00000507288_length(transcript)=6264nt_BP=5059nt
TCCGGTCGGCATTTTGTTCTGAGAGGGAGAGACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTC
CGTCGGTACCGACTCACCCGACACCACCAAGCCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCC
CCCCCGGTAGCTCGGGCCCGTGGTCGGGTGTTTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGT
CTTCTCGGCTGGTCTCCCCCCGGCTCTACATGTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGAT
TATAGTCTCTCGCCACAGCGGCCTCGGCCTCCCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTG
GCACCTGAACTAAGTACTTTTATAGGCAACACCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGC
GGGGATTGCTAGTCTCACAGACCTCCTGAACCAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGC
ACGAATAGCAGAAGAGGTGAACTGCCTTTTGGCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAAC
AGATCACATAGAGTTGAAAGATAACCTTGGCAGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCC
TAATGTTTTCAGGGAGAAAAGCATGCAGAACAGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCA
CAGTAGTCCTGCATCTTCCAATTATCAACAAACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAA
CAGATTTATGCCACAGCAAAATAGCCCAGTGCCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAG
TTACACAACACATCCACAGATGCAACAAGCATCGGTATCAAGTCCCATTGTTGCAGGTGGTTTGAGAAACATACATGATAATAAAGTTTC
TGGTCCGTTGTCTGGCAATTCAGCTAATCATCATGCTGATAATCCTAGACATGGTTCAAGTGAGGACTACCTACACATGGTGCACAGGCT
AAGTAGTGACGATGGAGATTCTTCAACAATGAGGAATGCTGCATCTTTTCCCTTGAGATCTCCACAGCCAGTATGCTCCCCTGCTGGAAG
TGAAGGAACTCCTAAAGGCTCAAGACCACCTTTAATCCTACAATCTCAGTCTCTACCTTGTTCATCACCTCGAGATGTTCCACCAGATAT
CTTGCTAGATTCTCCAGAAAGAAAACAAAAGAAGCAGAAGAAAATGAAATTAGGCAAGGATGAAAAAGAGCAGAGTGAGAAAGCGGCAAT
GTATGATATAATTAGTTCTCCATCCAAGGACTCTACTAAACTTACATTAAGACTTTCTCGTGTAAGGTCTTCAGACATGGACCAGCAAGA
GGATATGATTTCTGGTGTGGAAAATAGCAATGTTTCAGAAAATGATATTCCTTTTAATGTGCAGTACCCAGGACAGACTTCAAAAACACC
CATTACTCCACAAGATATAAACCGCCCACTAAATGCTGCTCAATGTTTGTCGCAGCAAGAACAAACAGCATTCCTTCCAGCAAATCAAGT
GCCTGTTTTACAACAGAACACTTCAGTTGCTGCAAAACAACCCCAGACTTCTGTGGTACAGAATCAACAACAGATATCACAACAGGGACC
TATATATGATGAAGTGGAATTGGATGCATTGGCTGAAATTGAGCGAATAGAGAGAGAATCAGCTATTGAAAGGGAGCGCTTCTCAAAAGA
AGTTCAAGATAAAGATAAGCCTTTGAAAAAAAGAAAACAAGATTCTTACCCACAGGAGGCTGGGGGTGCTACAGGAGGTAATAGACCAGC
TTCTCAGGAGACGGGTTCTACGGGAAATGGGTCAAGGCCAGCATTAATGGTTAGCATTGATCTTCATCAGGCAGGAAGAGTGGACTCTCA
GGCTTCTATAACTCAGGATTCAGACTCCATAAAAAAGCCTGAAGAAATCAAACAATGTAATGATGCACCTGTTTCTGTTCTTCAGGAAGA
TATTGTTGGAAGTCTTAAATCTACACCAGAAAACCATCCTGAGACACCTAAAAAAAAGTCTGATCCTGAGCTTTCAAAGAGTGAAATGAA
ACAAAGTGAAAGTAGATTAGCAGAATCTAAACCAAATGAAAACCGATTGGTGGAGACAAAATCAAGTGAAAATAAGTTAGAAACTAAAGT
TGAGACCCAAACAGAAGAACTTAAACAGAATGAGAGCAGAACAACTGAATGCAAACAAAACGAGAGCACCATAGTTGAGCCTAAACAAAA
TGAAAATAGACTGTCTGACACAAAACCAAATGACAACAAACAAAATAATGGCAGATCAGAAACAACAAAATCAAGGCCTGAAACCCCAAA
GCAAAAGGGTGAAAGCCGGCCTGAGACTCCAAAACAAAAGAGTGATGGGCATCCTGAAACCCCAAAACAGAAGGGTGATGGAAGGCCTGA
AACTCCAAAGCAAAAAGGTGAGAGCCGCCCTGAAACTCCAAAGCAAAAAAATGAAGGGCGACCTGAAACACCAAAACACAGGCATGACAA
TAGGAGGGATTCTGGAAAGCCATCTACAGAGAAAAAACCTGAAGTGTCTAAACATAAACAAGATACTAAATCTGACTCACCTCGGTTAAA
ATCAGAACGAGCTGAAGCCTTAAAGCAGAGACCTGATGGGCGATCTGTTTCTGAGTCACTAAGACGTGACCATGATAATAAACAAAAATC
AGATGACAGGGGTGAATCAGAGCGACATCGAGGGGATCAGTCTAGGGTTCGAAGACCAGAAACATTGAGATCCTCTAGTAGAAATGAACA
TGGCATTAAATCTGATAGTTCAAAAACTGATAAACTAGAACGAAAACACAGGCATGAATCAGGGGACTCAAGGGAAAGACCATCTTCTGG
GGAACAAAAATCAAGACCTGACAGTCCTCGTGTTAAACAAGGAGATTCTAATAAATCAAGATCTGATAAACTTGGTTTTAAATCACCAAC
TAGTAAAGATGACAAAAGGACAGAGGGTAACAAGAGTAAAGTAGACACTAATAAAGCACACCCTGACAATAAGGCAGAATTTCCAAGTTA
TTTGTTGGGGGGCAGGTCTGGTGCGTTGAAAAATTTTGTCATTCCGAAAATCAAGAGGGATAAAGATGGCAATGTTACTCAGGAGACAAA
GAAAATGGAAATGAAAGGAGAGCCGAAAGACAAAGTAGAAAAAATAGGATTAGTTGAAGATCTAAATAAAGGAGCTAAGCCTGTAGTTGT
GCTACAAAAACTGTCTTTGGATGATGTTCAGAAACTTATTAAAGATAGAGAGGACAAATCAAGAAGTTCCCTTAAACCTATCAAGAATAA
ACCATCAAAGTCAAATAAAGGTAGTATAGATCAATCAGTGTTAAAAGAATTACCCCCTGAACTCCTGGCAGAAATTGAGTCCACCATGCC
ACTTTGTGAACGTGTGAAAATGAACAAACGCAAGCGTAGCACAGTTAATGAAAAGCCAAAATATGCTGAAATCAGTTCAGATGAAGATAA
TGATAGTGATGAAGCTTTTGAATCCTCTAGGAAACGACATAAAAAAGATGATGATAAAGCTTGGGAATATGAAGAGCGTGACAGAAGAAG
CTCTGGGGATCATAGGAGAAGTGGCCACTCTCATGAAGGAAGAAGGAGTTCAGGTGGTGGTCGTTATCGAAACCGAAGTCCGTCAGATTC
TGACATGGAAGATTATTCTCCTCCTCCCAGCCTTAGTGAGGTTGCTAGGAAAATGAAGAAAAAAGAAAAACAGAAGAAAAGGAAAGCATA
TGAACCAAAACTAACACCTGAAGAAATGATGGACTCTTCAACTTTTAAGAGATTCACAGCCTCAATAGAGAATATTTTGGATAATTTGGA
AGATATGGATTTTACTGCGTTTGGTGATGATGATGAAATTCCTCAGGAACTGCTCTTAGGAAAACATCAGCTTAATGAACTTGGCAGTGA
ATCTGCTAAAATAAAAGCAATGGGTATAATGGATAAGCTTTCAACTGACAAAACTGTGAAAGTCTTAAATATCTTGGAGAAGAATATTCA
GGATGGGTCAAAGCTTTCCACTTTGTTAAATCATAATAACGATACTGAAGAAGAAGAAAGGTTATGGAGAGACCTTATTATGGAGAGAGT
TACAAAATCAGCGGATGCTTGTCTTACAACTATCAACATTATGACATCCCCTAACATGCCAAAAGCTGTGTACATTGAGGATGTAATTGA
AAGAGTTATACAGTACACTAAATTTCATTTGCAGAATACACTTTATCCTCAGTATGATCCTGTTTACAGATTAGATCCTCATGGAGGAGG
CTTATTAAGTTCAAAAGCAAAACGGGCTAAATGTTCTACCCATAAGCAGAGAGTAATAGTAATGCTTTATAACAAAGTTTGTGACATTGT
TAGCAGCTTATCAGAATTGCTAGAGATACAACTTCTTACAGACACAACAATTCTTCAGGTTTCATCTATGGGAATAACACCATTTTTTGT
GGAAAATGTCAGTGAACTACAGTTGTGTGCCATTAAGTTAGTCACTGCAGTATTCTCAAGATATGAAAAACATAGGCAGTTAATTTTGGA
AGAAATTTTTACTTCACTTGCAAGATTACCAACCAGCAAGAGGAGTTTAAGGAACTTCAGGTTAAACAGTAGTGATATGGATGGAGAACC
TATGTATATTCAGATGGTTACAGCACTGGTTTTACAACTTATTCAGTGTGTGGTACACTTACCATCATCAGAGAAGGACTCTAATGCAGA
AGAAGATTCAAATAAAAAAGGAACACGGGTCTGGCTGAGAGAAAATGGCCAGCATTTTCCAAGTACTGTAAATTCCTGTGCAGAAGGCAT
CGTCGTCTTCCGGACAGACTATGGTCAGGTATTCACTTACAAGCAGAGCACAATTACCCACCAGAAGGTGACTGCTATGCACCCCACGAA
CGAGGAGGGCGTGGATGACATGGCGTCCTTGACAGAGCTCCATGGCGGCTCCATCATGTATAACTTATTCCAGCGGTATAAGAGAAATCA
AATATATGTGCAGATAGGTTGAATATACCTAATCCAAAAACTCCAAATCCACAATGCTTCAAAATCCAAGACATTTTGCATGCTGATGTG
TTGCTGAAAGGAAATGCTCATTGGGAATATTTTGGATTTTGAATTTAACTTAAATTATGCTTAACCAGTACATAGTATGCAAATATTCCA
AAATCCAAAAAATATTGAAATCCACAACACTTTGTGTCCCAGGCATTTCACACAAGGGATGCTCAATCTATATTTTGAAACTCATACTTT
GCTGTCATTAGAGAAAAAACACAAGTTTGTTTTTTTTTGTAATAGTGTCTTGCTATGTTGCCCAGGCTAGACTCAAACTCCTGAGCTAAA
GTGATCCTCCTGCCTTAGCCTCCTGAGTACCTGGGATTACAGGCACGTGCCAGCATGCCCACCTAGACACAAGTTGTTATTGTACATTTT
CAATAGTCAAGAAAAAGTAAGTAAATTAGAAGGAAAAAAAAACTACACAAGGGTTTAAAAGGCAGACCCTTTTAAAAAGTTTTTTATTTA
TTTTCCTCTTTTCATGATAATAATGTTAAACCTGACAGCTAAATTGCCAATACATACTATGAATAAGATCTTGGTCTTGGAATAAGGTCA
TATTCTTCCTTTCTAAGGGGAAACCCGTAGGATTTTTGTGCATCCAATTTGCAGTTCAGTTCAGTTAATTATGCCATTGTAGACCTTCCG
TTTGAGGCTTGCAAAATTGTATATTATCCATAAAGCAGCCACCATGATTTTTTAAAATTATCATTGAAGCCATTCACCGGAGATGTCAGC
GTCTGTTGGACTCCGCTCACATCGAGACAAGACCGCCACCTGTCAGAACAGCCACTGCTTCTCCACATTTGATCCTGGCTCGGAGCAATG

>59206_59206_1_NIPBL-MYO10_NIPBL_chr5_37010327_ENST00000282516_MYO10_chr5_16877816_ENST00000507288_length(amino acids)=1610AA_BP=1520
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASF
PLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTL
RLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQT
SVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM
VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRL
VETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG
HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSV
SESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS
NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIG
LVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVN
EKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVAR
KMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTD
KTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERVIQYTKFHLQNTLYP
QYDPVYRLDPHGGGLLSSKAKRAKCSTHKQRVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA
VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQCVVHLPSSEKDSNAEEDSNKKGTRVWLRENG

--------------------------------------------------------------
>59206_59206_2_NIPBL-MYO10_NIPBL_chr5_37010327_ENST00000282516_MYO10_chr5_16877816_ENST00000513610_length(transcript)=12621nt_BP=5059nt
TCCGGTCGGCATTTTGTTCTGAGAGGGAGAGACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTC
CGTCGGTACCGACTCACCCGACACCACCAAGCCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCC
CCCCCGGTAGCTCGGGCCCGTGGTCGGGTGTTTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGT
CTTCTCGGCTGGTCTCCCCCCGGCTCTACATGTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGAT
TATAGTCTCTCGCCACAGCGGCCTCGGCCTCCCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTG
GCACCTGAACTAAGTACTTTTATAGGCAACACCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGC
GGGGATTGCTAGTCTCACAGACCTCCTGAACCAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGC
ACGAATAGCAGAAGAGGTGAACTGCCTTTTGGCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAAC
AGATCACATAGAGTTGAAAGATAACCTTGGCAGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCC
TAATGTTTTCAGGGAGAAAAGCATGCAGAACAGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCA
CAGTAGTCCTGCATCTTCCAATTATCAACAAACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAA
CAGATTTATGCCACAGCAAAATAGCCCAGTGCCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAG
TTACACAACACATCCACAGATGCAACAAGCATCGGTATCAAGTCCCATTGTTGCAGGTGGTTTGAGAAACATACATGATAATAAAGTTTC
TGGTCCGTTGTCTGGCAATTCAGCTAATCATCATGCTGATAATCCTAGACATGGTTCAAGTGAGGACTACCTACACATGGTGCACAGGCT
AAGTAGTGACGATGGAGATTCTTCAACAATGAGGAATGCTGCATCTTTTCCCTTGAGATCTCCACAGCCAGTATGCTCCCCTGCTGGAAG
TGAAGGAACTCCTAAAGGCTCAAGACCACCTTTAATCCTACAATCTCAGTCTCTACCTTGTTCATCACCTCGAGATGTTCCACCAGATAT
CTTGCTAGATTCTCCAGAAAGAAAACAAAAGAAGCAGAAGAAAATGAAATTAGGCAAGGATGAAAAAGAGCAGAGTGAGAAAGCGGCAAT
GTATGATATAATTAGTTCTCCATCCAAGGACTCTACTAAACTTACATTAAGACTTTCTCGTGTAAGGTCTTCAGACATGGACCAGCAAGA
GGATATGATTTCTGGTGTGGAAAATAGCAATGTTTCAGAAAATGATATTCCTTTTAATGTGCAGTACCCAGGACAGACTTCAAAAACACC
CATTACTCCACAAGATATAAACCGCCCACTAAATGCTGCTCAATGTTTGTCGCAGCAAGAACAAACAGCATTCCTTCCAGCAAATCAAGT
GCCTGTTTTACAACAGAACACTTCAGTTGCTGCAAAACAACCCCAGACTTCTGTGGTACAGAATCAACAACAGATATCACAACAGGGACC
TATATATGATGAAGTGGAATTGGATGCATTGGCTGAAATTGAGCGAATAGAGAGAGAATCAGCTATTGAAAGGGAGCGCTTCTCAAAAGA
AGTTCAAGATAAAGATAAGCCTTTGAAAAAAAGAAAACAAGATTCTTACCCACAGGAGGCTGGGGGTGCTACAGGAGGTAATAGACCAGC
TTCTCAGGAGACGGGTTCTACGGGAAATGGGTCAAGGCCAGCATTAATGGTTAGCATTGATCTTCATCAGGCAGGAAGAGTGGACTCTCA
GGCTTCTATAACTCAGGATTCAGACTCCATAAAAAAGCCTGAAGAAATCAAACAATGTAATGATGCACCTGTTTCTGTTCTTCAGGAAGA
TATTGTTGGAAGTCTTAAATCTACACCAGAAAACCATCCTGAGACACCTAAAAAAAAGTCTGATCCTGAGCTTTCAAAGAGTGAAATGAA
ACAAAGTGAAAGTAGATTAGCAGAATCTAAACCAAATGAAAACCGATTGGTGGAGACAAAATCAAGTGAAAATAAGTTAGAAACTAAAGT
TGAGACCCAAACAGAAGAACTTAAACAGAATGAGAGCAGAACAACTGAATGCAAACAAAACGAGAGCACCATAGTTGAGCCTAAACAAAA
TGAAAATAGACTGTCTGACACAAAACCAAATGACAACAAACAAAATAATGGCAGATCAGAAACAACAAAATCAAGGCCTGAAACCCCAAA
GCAAAAGGGTGAAAGCCGGCCTGAGACTCCAAAACAAAAGAGTGATGGGCATCCTGAAACCCCAAAACAGAAGGGTGATGGAAGGCCTGA
AACTCCAAAGCAAAAAGGTGAGAGCCGCCCTGAAACTCCAAAGCAAAAAAATGAAGGGCGACCTGAAACACCAAAACACAGGCATGACAA
TAGGAGGGATTCTGGAAAGCCATCTACAGAGAAAAAACCTGAAGTGTCTAAACATAAACAAGATACTAAATCTGACTCACCTCGGTTAAA
ATCAGAACGAGCTGAAGCCTTAAAGCAGAGACCTGATGGGCGATCTGTTTCTGAGTCACTAAGACGTGACCATGATAATAAACAAAAATC
AGATGACAGGGGTGAATCAGAGCGACATCGAGGGGATCAGTCTAGGGTTCGAAGACCAGAAACATTGAGATCCTCTAGTAGAAATGAACA
TGGCATTAAATCTGATAGTTCAAAAACTGATAAACTAGAACGAAAACACAGGCATGAATCAGGGGACTCAAGGGAAAGACCATCTTCTGG
GGAACAAAAATCAAGACCTGACAGTCCTCGTGTTAAACAAGGAGATTCTAATAAATCAAGATCTGATAAACTTGGTTTTAAATCACCAAC
TAGTAAAGATGACAAAAGGACAGAGGGTAACAAGAGTAAAGTAGACACTAATAAAGCACACCCTGACAATAAGGCAGAATTTCCAAGTTA
TTTGTTGGGGGGCAGGTCTGGTGCGTTGAAAAATTTTGTCATTCCGAAAATCAAGAGGGATAAAGATGGCAATGTTACTCAGGAGACAAA
GAAAATGGAAATGAAAGGAGAGCCGAAAGACAAAGTAGAAAAAATAGGATTAGTTGAAGATCTAAATAAAGGAGCTAAGCCTGTAGTTGT
GCTACAAAAACTGTCTTTGGATGATGTTCAGAAACTTATTAAAGATAGAGAGGACAAATCAAGAAGTTCCCTTAAACCTATCAAGAATAA
ACCATCAAAGTCAAATAAAGGTAGTATAGATCAATCAGTGTTAAAAGAATTACCCCCTGAACTCCTGGCAGAAATTGAGTCCACCATGCC
ACTTTGTGAACGTGTGAAAATGAACAAACGCAAGCGTAGCACAGTTAATGAAAAGCCAAAATATGCTGAAATCAGTTCAGATGAAGATAA
TGATAGTGATGAAGCTTTTGAATCCTCTAGGAAACGACATAAAAAAGATGATGATAAAGCTTGGGAATATGAAGAGCGTGACAGAAGAAG
CTCTGGGGATCATAGGAGAAGTGGCCACTCTCATGAAGGAAGAAGGAGTTCAGGTGGTGGTCGTTATCGAAACCGAAGTCCGTCAGATTC
TGACATGGAAGATTATTCTCCTCCTCCCAGCCTTAGTGAGGTTGCTAGGAAAATGAAGAAAAAAGAAAAACAGAAGAAAAGGAAAGCATA
TGAACCAAAACTAACACCTGAAGAAATGATGGACTCTTCAACTTTTAAGAGATTCACAGCCTCAATAGAGAATATTTTGGATAATTTGGA
AGATATGGATTTTACTGCGTTTGGTGATGATGATGAAATTCCTCAGGAACTGCTCTTAGGAAAACATCAGCTTAATGAACTTGGCAGTGA
ATCTGCTAAAATAAAAGCAATGGGTATAATGGATAAGCTTTCAACTGACAAAACTGTGAAAGTCTTAAATATCTTGGAGAAGAATATTCA
GGATGGGTCAAAGCTTTCCACTTTGTTAAATCATAATAACGATACTGAAGAAGAAGAAAGGTTATGGAGAGACCTTATTATGGAGAGAGT
TACAAAATCAGCGGATGCTTGTCTTACAACTATCAACATTATGACATCCCCTAACATGCCAAAAGCTGTGTACATTGAGGATGTAATTGA
AAGAGTTATACAGTACACTAAATTTCATTTGCAGAATACACTTTATCCTCAGTATGATCCTGTTTACAGATTAGATCCTCATGGAGGAGG
CTTATTAAGTTCAAAAGCAAAACGGGCTAAATGTTCTACCCATAAGCAGAGAGTAATAGTAATGCTTTATAACAAAGTTTGTGACATTGT
TAGCAGCTTATCAGAATTGCTAGAGATACAACTTCTTACAGACACAACAATTCTTCAGGTTTCATCTATGGGAATAACACCATTTTTTGT
GGAAAATGTCAGTGAACTACAGTTGTGTGCCATTAAGTTAGTCACTGCAGTATTCTCAAGATATGAAAAACATAGGCAGTTAATTTTGGA
AGAAATTTTTACTTCACTTGCAAGATTACCAACCAGCAAGAGGAGTTTAAGGAACTTCAGGTTAAACAGTAGTGATATGGATGGAGAACC
TATGTATATTCAGATGGTTACAGCACTGGTTTTACAACTTATTCAGTGTGTGGTACACTTACCATCATCAGAGAAGGACTCTAATGCAGA
AGAAGATTCAAATAAAAAAGGAACACGGGTCTGGCTGAGAGAAAATGGCCAGCATTTTCCAAGTACTGTAAATTCCTGTGCAGAAGGCAT
CGTCGTCTTCCGGACAGACTATGGTCAGGTATTCACTTACAAGCAGAGCACAATTACCCACCAGAAGGTGACTGCTATGCACCCCACGAA
CGAGGAGGGCGTGGATGACATGGCGTCCTTGACAGAGCTCCATGGCGGCTCCATCATGTATAACTTATTCCAGCGGTATAAGAGAAATCA
AATATATACCTACATCGGCTCCATCCTGGCCTCCGTGAACCCCTACCAGCCCATCGCCGGGCTGTACGAGCCTGCCACCATGGAGCAGTA
CAGCCGGCGCCACCTGGGCGAGCTGCCCCCGCACATCTTCGCCATCGCCAACGAGTGCTACCGCTGCCTGTGGAAGCGCCACGACAACCA
GTGCATCCTCATCAGTGGTGAAAGTGGGGCAGGTAAAACCGAAAGCACTAAATTGATCCTCAAGTTTCTGTCAGTCATCAGTCAACAGTC
TTTGGAATTGTCCTTAAAGGAGAAGACATCCTGTGTTGAACGAGCTATTCTTGAAAGCAGCCCCATCATGGAAGCTTTCGGCAATGCGAA
GACCGTGTACAACAACAACTCTAGTCGCTTTGGGAAGTTTGTTCAGCTGAACATCTGTCAGAAAGGAAATATTCAGGGCGGGAGAATTGT
AGATTATTTATTAGAAAAAAACCGAGTAGTAAGGCAAAATCCCGGGGAAAGGAATTATCACATATTTTATGCACTGCTGGCAGGGCTGGA
ACATGAAGAAAGAGAAGAATTTTATTTATCTACGCCAGAAAACTACCACTACTTGAATCAGTCTGGATGTGTAGAAGACAAGACAATCAG
TGACCAGGAATCCTTTAGGGAAGTTATTACGGCAATGGACGTGATGCAGTTCAGCAAGGAGGAAGTTCGGGAAGTGTCGAGGCTGCTTGC
TGGTATACTGCATCTTGGGAACATAGAATTTATCACTGCTGGTGGGGCACAGGTTTCCTTCAAAACAGCTTTGGGCAGATCTGCGGAGTT
ACTTGGGCTGGACCCAACACAGCTCACAGATGCTTTGACCCAGAGATCAATGTTCCTCAGGGGAGAAGAGATCCTCACGCCTCTCAATGT
TCAACAGGCAGTAGACAGCAGGGACTCCCTGGCCATGGCTCTGTATGCGTGCTGCTTTGAGTGGGTAATCAAGAAGATCAACAGCAGGAT
CAAAGGCAATGAGGACTTCAAGTCTATTGGCATCCTCGACATCTTTGGATTTGAAAACTTTGAGGTTAATCACTTTGAACAGTTCAATAT
AAACTATGCAAACGAGAAACTTCAGGAGTACTTCAACAAGCATATTTTTTCTTTAGAACAACTAGAATATAGCCGGGAAGGATTAGTGTG
GGAAGATATTGACTGGATAGACAATGGAGAATGCCTGGACTTGATTGAGAAGAAACTTGGCCTCCTAGCCCTTATCAATGAAGAAAGCCA
TTTTCCTCAAGCCACAGACAGCACCTTATTGGAGAAGCTACACAGTCAGCATGCGAATAACCACTTTTATGTGAAGCCCAGAGTTGCAGT
TAACAATTTTGGAGTGAAGCACTATGCTGGAGAGGTGCAATATGATGTCCGAGGTATCTTGGAGAAGAACAGAGATACATTTCGAGATGA
CCTTCTCAATTTGCTAAGAGAAAGCCGATTTGACTTTATCTACGATCTTTTTGAACATGTTTCAAGCCGCAACAACCAGGATACCTTGAA
ATGTGGAAGCAAACATCGGCGGCCTACAGTCAGCTCACAGTTCAAGGACTCACTGCATTCCTTAATGGCAACGCTAAGCTCCTCTAATCC
TTTCTTTGTTCGCTGTATCAAGCCAAACATGCAGAAGATGCCAGACCAGTTTGACCAGGCGGTTGTGCTGAACCAGCTGCGGTACTCAGG
GATGCTGGAGACTGTGAGAATCCGCAAAGCTGGGTATGCGGTCCGAAGACCCTTTCAGGACTTTTACAAAAGGTATAAAGTGCTGATGAG
GAATCTGGCTCTGCCTGAGGACGTCCGAGGGAAGTGCACGAGCCTGCTGCAGCTCTATGATGCCTCCAACAGCGAGTGGCAGCTGGGGAA
GACCAAGGTCTTTCTTCGAGAATCCTTGGAACAGAAACTGGAGAAGCGGAGGGAAGAGGAAGTGAGCCACGCGGCCATGGTGATTCGGGC
CCATGTCTTGGGCTTCTTAGCACGAAAACAATACAGAAAGGTCCTTTATTGTGTGGTGATAATACAGAAGAATTACAGAGCATTCCTTCT
GAGGAGGAGATTTTTGCACCTGAAAAAGGCAGCCATAGTTTTCCAGAAGCAACTCAGAGGTCAGATTGCTCGGAGAGTTTACAGACAATT
GCTGGCAGAGAAAAGGGAGCAAGAAGAAAAGAAGAAACAGGAAGAGGAAGAAAAGAAGAAACGGGAGGAAGAAGAAAGAGAAAGAGAGAG
AGAGCGAAGAGAAGCCGAGCTCCGCGCCCAGCAGGAAGAAGAAACGAGGAAGCAGCAAGAACTCGAAGCCTTGCAGAAGAGCCAGAAGGA
AGCTGAACTGACCCGTGAACTGGAGAAACAGAAGGAAAATAAGCAGGTGGAAGAGATCCTCCGTCTGGAGAAAGAAATCGAGGACCTGCA
GCGCATGAAGGAGCAGCAGGAGCTGTCGCTGACCGAGGCTTCCCTGCAGAAGCTGCAGGAGCGGCGGGACCAGGAGCTCCGCAGGCTGGA
GGAGGAAGCGTGCAGGGCGGCCCAGGAGTTCCTCGAGTCCCTCAATTTCGACGAGATCGACGAGTGTGTCCGGAATATCGAGCGGTCCCT
GTCGGTGGGAAGCGAATTTTCCAGCGAGCTGGCTGAGAGCGCATGCGAGGAGAAGCCCAACTTCAACTTCAGCCAGCCCTACCCAGAGGA
GGAGGTCGATGAGGGCTTCGAAGCCGACGACGACGCCTTCAAGGACTCCCCCAACCCCAGCGAGCACGGCCACTCAGACCAGCGAACAAG
TGGCATCCGGACCAGCGATGACTCTTCAGAGGAGGACCCATACATGAACGACACGGTGGTGCCCACCAGCCCCAGTGCGGACAGCACGGT
GCTGCTCGCCCCATCAGTGCAGGACTCCGGGAGCCTACACAACTCCTCCAGCGGCGAGTCCACCTACTGCATGCCCCAGAACGCTGGGGA
CTTGCCCTCCCCAGACGGCGACTACGACTACGACCAGGATGACTATGAGGACGGTGCCATCACTTCCGGCAGCAGCGTGACCTTCTCCAA
CTCCTACGGCAGCCAGTGGTCCCCCGACTACCGCTGCTCTGTGGGGACCTACAACAGCTCGGGTGCCTACCGGTTCAGCTCTGAGGGGGC
GCAGTCCTCGTTTGAAGATAGTGAAGAGGACTTTGATTCCAGGTTTGATACAGATGATGAGCTTTCATACCGGCGTGACTCTGTGTACAG
CTGTGTCACTCTGCCGTATTTCCACAGCTTTCTGTACATGAAAGGTGGCCTGATGAACTCTTGGAAACGCCGCTGGTGCGTCCTCAAGGA
TGAAACCTTCTTGTGGTTCCGCTCCAAGCAGGAGGCCCTCAAGCAAGGCTGGCTCCACAAAAAAGGGGGGGGCTCCTCCACGCTGTCCAG
GAGAAATTGGAAGAAGCGCTGGTTTGTCCTCCGCCAGTCCAAGCTGATGTACTTTGAAAACGACAGCGAGGAGAAGCTCAAGGGCACCGT
AGAAGTGCGAACGGCAAAAGAGATCATAGATAACACCACCAAGGAGAATGGGATCGACATCATTATGGCCGATAGGACTTTCCACCTGAT
TGCAGAGTCCCCAGAAGATGCCAGCCAGTGGTTCAGCGTGCTGAGTCAGGTCCACGCGTCCACGGACCAGGAGATCCAGGAGATGCATGA
TGAGCAGGCAAACCCACAGAATGCTGTGGGCACCTTGGATGTGGGGCTGATTGATTCTGTGTGTGCCTCTGACAGCCCTGATAGACCCAA
CTCGTTTGTGATCATCACGGCCAACCGGGTGCTGCACTGCAACGCCGACACGCCGGAGGAGATGCACCACTGGATAACCCTGCTGCAGAG
GTCCAAAGGGGACACCAGAGTGGAGGGCCAGGAATTCATCGTGAGAGGATGGTTGCACAAAGAGGTGAAGAACAGTCCAAAGATGTCTTC
ACTGAAACTGAAGAAACGGTGGTTTGTACTCACCCACAATTCCCTGGATTACTACAAGAGTTCAGAGAAGAACGCGCTCAAACTGGGGAC
CCTGGTCCTCAACAGCCTCTGCTCTGTCGTCCCCCCAGATGAGAAGATATTCAAAGAGACAGGCTACTGGAACGTCACCGTGTACGGGCG
CAAGCACTGTTACCGGCTCTACACCAAGCTGCTCAACGAGGCCACCCGGTGGTCCAGTGCCATTCAAAACGTGACTGACACCAAGGCCCC
GATCGACACCCCCACCCAGCAGCTGATTCAAGATATCAAGGAGAACTGCCTGAACTCGGATGTGGTGGAACAGATTTACAAGCGGAACCC
GATCCTTCGATACACCCATCACCCCTTGCACTCCCCGCTCCTGCCCCTTCCGTATGGGGACATAAATCTCAACTTGCTCAAAGACAAAGG
CTATACCACCCTTCAGGATGAGGCCATCAAGATATTCAATTCCCTGCAGCAACTGGAGTCCATGTCTGACCCAATTCCAATAATCCAGGG
CATCCTACAGACAGGGCATGACCTGCGACCTCTGCGGGACGAGCTGTACTGCCAGCTTATCAAACAGACCAACAAAGTGCCCCACCCCGG
CAGTGTGGGCAACCTGTACAGCTGGCAGATCCTGACATGCCTGAGCTGCACCTTCCTGCCGAGTCGAGGGATTCTCAAGTATCTCAAGTT
CCATCTGAAAAGGATACGGGAACAGTTTCCAGGAAGCGAGATGGAAAAATACGCTCTCTTCACTTACGAATCTCTTAAGAAAACCAAATG
CCGAGAGTTTGTGCCTTCCCGAGATGAAATAGAAGCTCTGATCCACAGGCAGGAAATGACATCCACGGTCTATTGCCATGGCGGCGGCTC
CTGCAAGATCACCATCAACTCCCACACCACCGCTGGGGAGGTGGTGGAGAAGCTGATCCGAGGCCTGGCCATGGAGGACAGCAGGAACAT
GTTTGCTTTGTTTGAATACAACGGCCACGTCGACAAAGCCATTGAAAGTCGAACCGTCGTAGCTGATGTCTTAGCCAAGTTTGAAAAGCT
GGCTGCCACATCCGAGGTTGGGGACCTGCCATGGAAATTCTACTTCAAACTTTACTGCTTCCTGGACACAGACAACGTGCCAAAAGACAG
TGTGGAGTTTGCATTTATGTTTGAACAGGCCCACGAAGCGGTTATCCATGGCCACCATCCAGCCCCGGAAGAAAACCTCCAGGTTCTTGC
TGCCCTGCGACTCCAGTATCTGCAGGGGGATTATACTCTGCACGCTGCCATCCCACCTCTCGAAGAGGTTTATTCCCTGCAGAGACTCAA
GGCCCGCATCAGCCAGTCAACCAAAACCTTCACCCCTTGTGAACGGCTGGAGAAGAGGCGGACGAGCTTCCTAGAGGGGACCCTGAGGCG
GAGCTTCCGGACAGGATCCGTGGTCCGGCAGAAGGTCGAGGAGGAGCAGATGCTGGACATGTGGATTAAGGAAGAAGTCTCCTCTGCTCG
AGCCAGTATCATTGACAAGTGGAGGAAATTTCAGGGAATGAACCAGGAACAGGCCATGGCCAAGTACATGGCCTTGATCAAGGAGTGGCC
TGGCTATGGCTCGACGCTGTTTGATGTGGAGTGCAAGGAAGGTGGCTTCCCTCAGGAACTCTGGTTGGGTGTCAGCGCGGACGCCGTCTC
CGTCTACAAGCGTGGAGAGGGAAGACCACTGGAAGTCTTCCAGTATGAACACATCCTCTCTTTTGGGGCACCCCTGGCGAATACGTATAA
GATCGTGGTCGATGAGAGGGAGCTGCTCTTTGAAACCAGTGAGGTGGTGGATGTGGCCAAGCTCATGAAAGCCTACATCAGCATGATCGT
GAAGAAGCGCTACAGCACGACACGCTCCGCCAGCAGCCAGGGCAGCTCCAGGTGAAGGCGGGACAGAGCCCACCTGTCTTTGCTACCTGA
ACGCACCACCCTCTGGCCTAGGCTGGCTCCAGTGTGCCATGCCCAGCCAAAACAAACACAGAGCTGCCCAGGCTTTCTGGAAGCTTCTGG
TCTGAGGGAGGTGTCTCCGAGGATCCTTTTGCCTGCCGCCTTCATTGATCCTGTATTAAGCTGTCAACTTTAACAGTCTGCACAGTTTCC
AAAGCTTTACTACTCTTAGAGGACACATGCCTTAAAAAAGGAGGGGAGGAACCACGCTGCCACCAAAGCAGCCGGAAGTGCCTTAACTTG
TGGAACCAACACTAATCGACCGTAACTGTGCTACTGAAGGGAACTGCCTTTCCCCCTTCTGGGGGAGACTTAACAGAGCGTGGAAGGGGG
GCATTCTCTGTCAATGATGCACTAACCTCCCAACCTGATTTCCCCGAATCTGAGGGAAGGTGAGGGAGTGGGAAGGGGGATGGAGAGCTC
GAGGGGACAGTGTGTTTGAGCTGGAGTGCTGCGGGCAGCCTTTCTCATGGAATGACATGAATCAACTTTTTTCTTTGTTTCATCTTTTAA
GTGTACGTGCTTGCCTGTTCGTGCATGTGTTCATAAACTCAACACTTTAATCATGGTTTCATGAGCATTAAAAAGCAAAGGGAAAAAGGA
TGTGTAATGGTGTACACAGTCTGTATATTTTAATAATGCAGAGCTATAGTCTCAATTGTTACTTTATAAGGTGGTTTTATTAACAAACCC
AAATCCTGGATTTTCCTGTCTTTGCTGTATTTTGAAAAACACGTGTTGACTCCATTGTTTTACATGTAGCAAAGTCTGCCATCTGTGTCT
GCTGTATTATAAACAGATAAGCAGCCTACAAGATAACTGTATTTATAAACCACTCTTCAACAGCTGGCTCCAGTGCTGGTTTTAGAACAA
GAATGAAGTCATTTTGGAGTCTTTCATGTCTAAAAGATTTAAGTTAAAAACAAAGTGTTACTTGGAAGGTTAGCTTCTATCATTCTGGAT
AGATTACAGATATAATAACCATGTTGACTATGGGGGAGAGACGCTGCATTCCAGAAACGTCTTAACACTTGAGTGAATCTTCAAAGGACC
CTGACATTAAATGCTGAGGCTTTAATACACACATATTTTATCCCAAGTTTATAATGGTGGTCTGAACAAGGCACCTGTAAATAAATCAGC
ATTTATGACCAGAAGAAAAATAATCTGGTCTTGGACTTTTTATTTTTATATGGAAAAGTTTTAAGGACTTGGGCCAACTAAGTCTACCCA
CACGAAAAAAGAAATTTGCCTTGTCCCTTTGTGTACAACCATGCAAAACTGTTTGTTGGCTCACAGAAGTTCTGACAATAAAAGATACTA

>59206_59206_2_NIPBL-MYO10_NIPBL_chr5_37010327_ENST00000282516_MYO10_chr5_16877816_ENST00000513610_length(amino acids)=3571AA_BP=1520
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASF
PLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTL
RLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQT
SVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM
VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRL
VETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG
HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSV
SESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS
NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIG
LVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVN
EKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVAR
KMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTD
KTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERVIQYTKFHLQNTLYP
QYDPVYRLDPHGGGLLSSKAKRAKCSTHKQRVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA
VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQCVVHLPSSEKDSNAEEDSNKKGTRVWLRENG
QHFPSTVNSCAEGIVVFRTDYGQVFTYKQSTITHQKVTAMHPTNEEGVDDMASLTELHGGSIMYNLFQRYKRNQIYTYIGSILASVNPYQ
PIAGLYEPATMEQYSRRHLGELPPHIFAIANECYRCLWKRHDNQCILISGESGAGKTESTKLILKFLSVISQQSLELSLKEKTSCVERAI
LESSPIMEAFGNAKTVYNNNSSRFGKFVQLNICQKGNIQGGRIVDYLLEKNRVVRQNPGERNYHIFYALLAGLEHEEREEFYLSTPENYH
YLNQSGCVEDKTISDQESFREVITAMDVMQFSKEEVREVSRLLAGILHLGNIEFITAGGAQVSFKTALGRSAELLGLDPTQLTDALTQRS
MFLRGEEILTPLNVQQAVDSRDSLAMALYACCFEWVIKKINSRIKGNEDFKSIGILDIFGFENFEVNHFEQFNINYANEKLQEYFNKHIF
SLEQLEYSREGLVWEDIDWIDNGECLDLIEKKLGLLALINEESHFPQATDSTLLEKLHSQHANNHFYVKPRVAVNNFGVKHYAGEVQYDV
RGILEKNRDTFRDDLLNLLRESRFDFIYDLFEHVSSRNNQDTLKCGSKHRRPTVSSQFKDSLHSLMATLSSSNPFFVRCIKPNMQKMPDQ
FDQAVVLNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRYKVLMRNLALPEDVRGKCTSLLQLYDASNSEWQLGKTKVFLRESLEQKLEKR
REEEVSHAAMVIRAHVLGFLARKQYRKVLYCVVIIQKNYRAFLLRRRFLHLKKAAIVFQKQLRGQIARRVYRQLLAEKREQEEKKKQEEE
EKKKREEEERERERERREAELRAQQEEETRKQQELEALQKSQKEAELTRELEKQKENKQVEEILRLEKEIEDLQRMKEQQELSLTEASLQ
KLQERRDQELRRLEEEACRAAQEFLESLNFDEIDECVRNIERSLSVGSEFSSELAESACEEKPNFNFSQPYPEEEVDEGFEADDDAFKDS
PNPSEHGHSDQRTSGIRTSDDSSEEDPYMNDTVVPTSPSADSTVLLAPSVQDSGSLHNSSSGESTYCMPQNAGDLPSPDGDYDYDQDDYE
DGAITSGSSVTFSNSYGSQWSPDYRCSVGTYNSSGAYRFSSEGAQSSFEDSEEDFDSRFDTDDELSYRRDSVYSCVTLPYFHSFLYMKGG
LMNSWKRRWCVLKDETFLWFRSKQEALKQGWLHKKGGGSSTLSRRNWKKRWFVLRQSKLMYFENDSEEKLKGTVEVRTAKEIIDNTTKEN
GIDIIMADRTFHLIAESPEDASQWFSVLSQVHASTDQEIQEMHDEQANPQNAVGTLDVGLIDSVCASDSPDRPNSFVIITANRVLHCNAD
TPEEMHHWITLLQRSKGDTRVEGQEFIVRGWLHKEVKNSPKMSSLKLKKRWFVLTHNSLDYYKSSEKNALKLGTLVLNSLCSVVPPDEKI
FKETGYWNVTVYGRKHCYRLYTKLLNEATRWSSAIQNVTDTKAPIDTPTQQLIQDIKENCLNSDVVEQIYKRNPILRYTHHPLHSPLLPL
PYGDINLNLLKDKGYTTLQDEAIKIFNSLQQLESMSDPIPIIQGILQTGHDLRPLRDELYCQLIKQTNKVPHPGSVGNLYSWQILTCLSC
TFLPSRGILKYLKFHLKRIREQFPGSEMEKYALFTYESLKKTKCREFVPSRDEIEALIHRQEMTSTVYCHGGGSCKITINSHTTAGEVVE
KLIRGLAMEDSRNMFALFEYNGHVDKAIESRTVVADVLAKFEKLAATSEVGDLPWKFYFKLYCFLDTDNVPKDSVEFAFMFEQAHEAVIH
GHHPAPEENLQVLAALRLQYLQGDYTLHAAIPPLEEVYSLQRLKARISQSTKTFTPCERLEKRRTSFLEGTLRRSFRTGSVVRQKVEEEQ
MLDMWIKEEVSSARASIIDKWRKFQGMNQEQAMAKYMALIKEWPGYGSTLFDVECKEGGFPQELWLGVSADAVSVYKRGEGRPLEVFQYE

--------------------------------------------------------------
>59206_59206_3_NIPBL-MYO10_NIPBL_chr5_37010327_ENST00000448238_MYO10_chr5_16877816_ENST00000507288_length(transcript)=6233nt_BP=5028nt
ACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTCCGTCGGTACCGACTCACCCGACACCACCAAG
CCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCCCCCCCGGTAGCTCGGGCCCGTGGTCGGGTGT
TTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGTCTTCTCGGCTGGTCTCCCCCCGGCTCTACAT
GTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGATTATAGTCTCTCGCCACAGCGGCCTCGGCCTC
CCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTGGCACCTGAACTAAGTACTTTTATAGGCAACA
CCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGCGGGGATTGCTAGTCTCACAGACCTCCTGAAC
CAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGCACGAATAGCAGAAGAGGTGAACTGCCTTTTG
GCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAACAGATCACATAGAGTTGAAAGATAACCTTGGC
AGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCCTAATGTTTTCAGGGAGAAAAGCATGCAGAAC
AGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCACAGTAGTCCTGCATCTTCCAATTATCAACAA
ACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAACAGATTTATGCCACAGCAAAATAGCCCAGTG
CCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAGTTACACAACACATCCACAGATGCAACAAGCA
TCGGTATCAAGTCCCATTGTTGCAGGTGGTTTGAGAAACATACATGATAATAAAGTTTCTGGTCCGTTGTCTGGCAATTCAGCTAATCAT
CATGCTGATAATCCTAGACATGGTTCAAGTGAGGACTACCTACACATGGTGCACAGGCTAAGTAGTGACGATGGAGATTCTTCAACAATG
AGGAATGCTGCATCTTTTCCCTTGAGATCTCCACAGCCAGTATGCTCCCCTGCTGGAAGTGAAGGAACTCCTAAAGGCTCAAGACCACCT
TTAATCCTACAATCTCAGTCTCTACCTTGTTCATCACCTCGAGATGTTCCACCAGATATCTTGCTAGATTCTCCAGAAAGAAAACAAAAG
AAGCAGAAGAAAATGAAATTAGGCAAGGATGAAAAAGAGCAGAGTGAGAAAGCGGCAATGTATGATATAATTAGTTCTCCATCCAAGGAC
TCTACTAAACTTACATTAAGACTTTCTCGTGTAAGGTCTTCAGACATGGACCAGCAAGAGGATATGATTTCTGGTGTGGAAAATAGCAAT
GTTTCAGAAAATGATATTCCTTTTAATGTGCAGTACCCAGGACAGACTTCAAAAACACCCATTACTCCACAAGATATAAACCGCCCACTA
AATGCTGCTCAATGTTTGTCGCAGCAAGAACAAACAGCATTCCTTCCAGCAAATCAAGTGCCTGTTTTACAACAGAACACTTCAGTTGCT
GCAAAACAACCCCAGACTTCTGTGGTACAGAATCAACAACAGATATCACAACAGGGACCTATATATGATGAAGTGGAATTGGATGCATTG
GCTGAAATTGAGCGAATAGAGAGAGAATCAGCTATTGAAAGGGAGCGCTTCTCAAAAGAAGTTCAAGATAAAGATAAGCCTTTGAAAAAA
AGAAAACAAGATTCTTACCCACAGGAGGCTGGGGGTGCTACAGGAGGTAATAGACCAGCTTCTCAGGAGACGGGTTCTACGGGAAATGGG
TCAAGGCCAGCATTAATGGTTAGCATTGATCTTCATCAGGCAGGAAGAGTGGACTCTCAGGCTTCTATAACTCAGGATTCAGACTCCATA
AAAAAGCCTGAAGAAATCAAACAATGTAATGATGCACCTGTTTCTGTTCTTCAGGAAGATATTGTTGGAAGTCTTAAATCTACACCAGAA
AACCATCCTGAGACACCTAAAAAAAAGTCTGATCCTGAGCTTTCAAAGAGTGAAATGAAACAAAGTGAAAGTAGATTAGCAGAATCTAAA
CCAAATGAAAACCGATTGGTGGAGACAAAATCAAGTGAAAATAAGTTAGAAACTAAAGTTGAGACCCAAACAGAAGAACTTAAACAGAAT
GAGAGCAGAACAACTGAATGCAAACAAAACGAGAGCACCATAGTTGAGCCTAAACAAAATGAAAATAGACTGTCTGACACAAAACCAAAT
GACAACAAACAAAATAATGGCAGATCAGAAACAACAAAATCAAGGCCTGAAACCCCAAAGCAAAAGGGTGAAAGCCGGCCTGAGACTCCA
AAACAAAAGAGTGATGGGCATCCTGAAACCCCAAAACAGAAGGGTGATGGAAGGCCTGAAACTCCAAAGCAAAAAGGTGAGAGCCGCCCT
GAAACTCCAAAGCAAAAAAATGAAGGGCGACCTGAAACACCAAAACACAGGCATGACAATAGGAGGGATTCTGGAAAGCCATCTACAGAG
AAAAAACCTGAAGTGTCTAAACATAAACAAGATACTAAATCTGACTCACCTCGGTTAAAATCAGAACGAGCTGAAGCCTTAAAGCAGAGA
CCTGATGGGCGATCTGTTTCTGAGTCACTAAGACGTGACCATGATAATAAACAAAAATCAGATGACAGGGGTGAATCAGAGCGACATCGA
GGGGATCAGTCTAGGGTTCGAAGACCAGAAACATTGAGATCCTCTAGTAGAAATGAACATGGCATTAAATCTGATAGTTCAAAAACTGAT
AAACTAGAACGAAAACACAGGCATGAATCAGGGGACTCAAGGGAAAGACCATCTTCTGGGGAACAAAAATCAAGACCTGACAGTCCTCGT
GTTAAACAAGGAGATTCTAATAAATCAAGATCTGATAAACTTGGTTTTAAATCACCAACTAGTAAAGATGACAAAAGGACAGAGGGTAAC
AAGAGTAAAGTAGACACTAATAAAGCACACCCTGACAATAAGGCAGAATTTCCAAGTTATTTGTTGGGGGGCAGGTCTGGTGCGTTGAAA
AATTTTGTCATTCCGAAAATCAAGAGGGATAAAGATGGCAATGTTACTCAGGAGACAAAGAAAATGGAAATGAAAGGAGAGCCGAAAGAC
AAAGTAGAAAAAATAGGATTAGTTGAAGATCTAAATAAAGGAGCTAAGCCTGTAGTTGTGCTACAAAAACTGTCTTTGGATGATGTTCAG
AAACTTATTAAAGATAGAGAGGACAAATCAAGAAGTTCCCTTAAACCTATCAAGAATAAACCATCAAAGTCAAATAAAGGTAGTATAGAT
CAATCAGTGTTAAAAGAATTACCCCCTGAACTCCTGGCAGAAATTGAGTCCACCATGCCACTTTGTGAACGTGTGAAAATGAACAAACGC
AAGCGTAGCACAGTTAATGAAAAGCCAAAATATGCTGAAATCAGTTCAGATGAAGATAATGATAGTGATGAAGCTTTTGAATCCTCTAGG
AAACGACATAAAAAAGATGATGATAAAGCTTGGGAATATGAAGAGCGTGACAGAAGAAGCTCTGGGGATCATAGGAGAAGTGGCCACTCT
CATGAAGGAAGAAGGAGTTCAGGTGGTGGTCGTTATCGAAACCGAAGTCCGTCAGATTCTGACATGGAAGATTATTCTCCTCCTCCCAGC
CTTAGTGAGGTTGCTAGGAAAATGAAGAAAAAAGAAAAACAGAAGAAAAGGAAAGCATATGAACCAAAACTAACACCTGAAGAAATGATG
GACTCTTCAACTTTTAAGAGATTCACAGCCTCAATAGAGAATATTTTGGATAATTTGGAAGATATGGATTTTACTGCGTTTGGTGATGAT
GATGAAATTCCTCAGGAACTGCTCTTAGGAAAACATCAGCTTAATGAACTTGGCAGTGAATCTGCTAAAATAAAAGCAATGGGTATAATG
GATAAGCTTTCAACTGACAAAACTGTGAAAGTCTTAAATATCTTGGAGAAGAATATTCAGGATGGGTCAAAGCTTTCCACTTTGTTAAAT
CATAATAACGATACTGAAGAAGAAGAAAGGTTATGGAGAGACCTTATTATGGAGAGAGTTACAAAATCAGCGGATGCTTGTCTTACAACT
ATCAACATTATGACATCCCCTAACATGCCAAAAGCTGTGTACATTGAGGATGTAATTGAAAGAGTTATACAGTACACTAAATTTCATTTG
CAGAATACACTTTATCCTCAGTATGATCCTGTTTACAGATTAGATCCTCATGGAGGAGGCTTATTAAGTTCAAAAGCAAAACGGGCTAAA
TGTTCTACCCATAAGCAGAGAGTAATAGTAATGCTTTATAACAAAGTTTGTGACATTGTTAGCAGCTTATCAGAATTGCTAGAGATACAA
CTTCTTACAGACACAACAATTCTTCAGGTTTCATCTATGGGAATAACACCATTTTTTGTGGAAAATGTCAGTGAACTACAGTTGTGTGCC
ATTAAGTTAGTCACTGCAGTATTCTCAAGATATGAAAAACATAGGCAGTTAATTTTGGAAGAAATTTTTACTTCACTTGCAAGATTACCA
ACCAGCAAGAGGAGTTTAAGGAACTTCAGGTTAAACAGTAGTGATATGGATGGAGAACCTATGTATATTCAGATGGTTACAGCACTGGTT
TTACAACTTATTCAGTGTGTGGTACACTTACCATCATCAGAGAAGGACTCTAATGCAGAAGAAGATTCAAATAAAAAAGGAACACGGGTC
TGGCTGAGAGAAAATGGCCAGCATTTTCCAAGTACTGTAAATTCCTGTGCAGAAGGCATCGTCGTCTTCCGGACAGACTATGGTCAGGTA
TTCACTTACAAGCAGAGCACAATTACCCACCAGAAGGTGACTGCTATGCACCCCACGAACGAGGAGGGCGTGGATGACATGGCGTCCTTG
ACAGAGCTCCATGGCGGCTCCATCATGTATAACTTATTCCAGCGGTATAAGAGAAATCAAATATATGTGCAGATAGGTTGAATATACCTA
ATCCAAAAACTCCAAATCCACAATGCTTCAAAATCCAAGACATTTTGCATGCTGATGTGTTGCTGAAAGGAAATGCTCATTGGGAATATT
TTGGATTTTGAATTTAACTTAAATTATGCTTAACCAGTACATAGTATGCAAATATTCCAAAATCCAAAAAATATTGAAATCCACAACACT
TTGTGTCCCAGGCATTTCACACAAGGGATGCTCAATCTATATTTTGAAACTCATACTTTGCTGTCATTAGAGAAAAAACACAAGTTTGTT
TTTTTTTGTAATAGTGTCTTGCTATGTTGCCCAGGCTAGACTCAAACTCCTGAGCTAAAGTGATCCTCCTGCCTTAGCCTCCTGAGTACC
TGGGATTACAGGCACGTGCCAGCATGCCCACCTAGACACAAGTTGTTATTGTACATTTTCAATAGTCAAGAAAAAGTAAGTAAATTAGAA
GGAAAAAAAAACTACACAAGGGTTTAAAAGGCAGACCCTTTTAAAAAGTTTTTTATTTATTTTCCTCTTTTCATGATAATAATGTTAAAC
CTGACAGCTAAATTGCCAATACATACTATGAATAAGATCTTGGTCTTGGAATAAGGTCATATTCTTCCTTTCTAAGGGGAAACCCGTAGG
ATTTTTGTGCATCCAATTTGCAGTTCAGTTCAGTTAATTATGCCATTGTAGACCTTCCGTTTGAGGCTTGCAAAATTGTATATTATCCAT
AAAGCAGCCACCATGATTTTTTAAAATTATCATTGAAGCCATTCACCGGAGATGTCAGCGTCTGTTGGACTCCGCTCACATCGAGACAAG
ACCGCCACCTGTCAGAACAGCCACTGCTTCTCCACATTTGATCCTGGCTCGGAGCAATGCCTGTCTATATCTTTAAAAGAGAAAAAAAAT

>59206_59206_3_NIPBL-MYO10_NIPBL_chr5_37010327_ENST00000448238_MYO10_chr5_16877816_ENST00000507288_length(amino acids)=1610AA_BP=1520
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASF
PLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTL
RLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQT
SVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM
VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRL
VETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG
HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSV
SESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS
NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIG
LVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVN
EKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVAR
KMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTD
KTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERVIQYTKFHLQNTLYP
QYDPVYRLDPHGGGLLSSKAKRAKCSTHKQRVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA
VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQCVVHLPSSEKDSNAEEDSNKKGTRVWLRENG

--------------------------------------------------------------
>59206_59206_4_NIPBL-MYO10_NIPBL_chr5_37010327_ENST00000448238_MYO10_chr5_16877816_ENST00000513610_length(transcript)=12590nt_BP=5028nt
ACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTCCGTCGGTACCGACTCACCCGACACCACCAAG
CCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCCCCCCCGGTAGCTCGGGCCCGTGGTCGGGTGT
TTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGTCTTCTCGGCTGGTCTCCCCCCGGCTCTACAT
GTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGATTATAGTCTCTCGCCACAGCGGCCTCGGCCTC
CCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTGGCACCTGAACTAAGTACTTTTATAGGCAACA
CCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGCGGGGATTGCTAGTCTCACAGACCTCCTGAAC
CAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGCACGAATAGCAGAAGAGGTGAACTGCCTTTTG
GCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAACAGATCACATAGAGTTGAAAGATAACCTTGGC
AGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCCTAATGTTTTCAGGGAGAAAAGCATGCAGAAC
AGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCACAGTAGTCCTGCATCTTCCAATTATCAACAA
ACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAACAGATTTATGCCACAGCAAAATAGCCCAGTG
CCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAGTTACACAACACATCCACAGATGCAACAAGCA
TCGGTATCAAGTCCCATTGTTGCAGGTGGTTTGAGAAACATACATGATAATAAAGTTTCTGGTCCGTTGTCTGGCAATTCAGCTAATCAT
CATGCTGATAATCCTAGACATGGTTCAAGTGAGGACTACCTACACATGGTGCACAGGCTAAGTAGTGACGATGGAGATTCTTCAACAATG
AGGAATGCTGCATCTTTTCCCTTGAGATCTCCACAGCCAGTATGCTCCCCTGCTGGAAGTGAAGGAACTCCTAAAGGCTCAAGACCACCT
TTAATCCTACAATCTCAGTCTCTACCTTGTTCATCACCTCGAGATGTTCCACCAGATATCTTGCTAGATTCTCCAGAAAGAAAACAAAAG
AAGCAGAAGAAAATGAAATTAGGCAAGGATGAAAAAGAGCAGAGTGAGAAAGCGGCAATGTATGATATAATTAGTTCTCCATCCAAGGAC
TCTACTAAACTTACATTAAGACTTTCTCGTGTAAGGTCTTCAGACATGGACCAGCAAGAGGATATGATTTCTGGTGTGGAAAATAGCAAT
GTTTCAGAAAATGATATTCCTTTTAATGTGCAGTACCCAGGACAGACTTCAAAAACACCCATTACTCCACAAGATATAAACCGCCCACTA
AATGCTGCTCAATGTTTGTCGCAGCAAGAACAAACAGCATTCCTTCCAGCAAATCAAGTGCCTGTTTTACAACAGAACACTTCAGTTGCT
GCAAAACAACCCCAGACTTCTGTGGTACAGAATCAACAACAGATATCACAACAGGGACCTATATATGATGAAGTGGAATTGGATGCATTG
GCTGAAATTGAGCGAATAGAGAGAGAATCAGCTATTGAAAGGGAGCGCTTCTCAAAAGAAGTTCAAGATAAAGATAAGCCTTTGAAAAAA
AGAAAACAAGATTCTTACCCACAGGAGGCTGGGGGTGCTACAGGAGGTAATAGACCAGCTTCTCAGGAGACGGGTTCTACGGGAAATGGG
TCAAGGCCAGCATTAATGGTTAGCATTGATCTTCATCAGGCAGGAAGAGTGGACTCTCAGGCTTCTATAACTCAGGATTCAGACTCCATA
AAAAAGCCTGAAGAAATCAAACAATGTAATGATGCACCTGTTTCTGTTCTTCAGGAAGATATTGTTGGAAGTCTTAAATCTACACCAGAA
AACCATCCTGAGACACCTAAAAAAAAGTCTGATCCTGAGCTTTCAAAGAGTGAAATGAAACAAAGTGAAAGTAGATTAGCAGAATCTAAA
CCAAATGAAAACCGATTGGTGGAGACAAAATCAAGTGAAAATAAGTTAGAAACTAAAGTTGAGACCCAAACAGAAGAACTTAAACAGAAT
GAGAGCAGAACAACTGAATGCAAACAAAACGAGAGCACCATAGTTGAGCCTAAACAAAATGAAAATAGACTGTCTGACACAAAACCAAAT
GACAACAAACAAAATAATGGCAGATCAGAAACAACAAAATCAAGGCCTGAAACCCCAAAGCAAAAGGGTGAAAGCCGGCCTGAGACTCCA
AAACAAAAGAGTGATGGGCATCCTGAAACCCCAAAACAGAAGGGTGATGGAAGGCCTGAAACTCCAAAGCAAAAAGGTGAGAGCCGCCCT
GAAACTCCAAAGCAAAAAAATGAAGGGCGACCTGAAACACCAAAACACAGGCATGACAATAGGAGGGATTCTGGAAAGCCATCTACAGAG
AAAAAACCTGAAGTGTCTAAACATAAACAAGATACTAAATCTGACTCACCTCGGTTAAAATCAGAACGAGCTGAAGCCTTAAAGCAGAGA
CCTGATGGGCGATCTGTTTCTGAGTCACTAAGACGTGACCATGATAATAAACAAAAATCAGATGACAGGGGTGAATCAGAGCGACATCGA
GGGGATCAGTCTAGGGTTCGAAGACCAGAAACATTGAGATCCTCTAGTAGAAATGAACATGGCATTAAATCTGATAGTTCAAAAACTGAT
AAACTAGAACGAAAACACAGGCATGAATCAGGGGACTCAAGGGAAAGACCATCTTCTGGGGAACAAAAATCAAGACCTGACAGTCCTCGT
GTTAAACAAGGAGATTCTAATAAATCAAGATCTGATAAACTTGGTTTTAAATCACCAACTAGTAAAGATGACAAAAGGACAGAGGGTAAC
AAGAGTAAAGTAGACACTAATAAAGCACACCCTGACAATAAGGCAGAATTTCCAAGTTATTTGTTGGGGGGCAGGTCTGGTGCGTTGAAA
AATTTTGTCATTCCGAAAATCAAGAGGGATAAAGATGGCAATGTTACTCAGGAGACAAAGAAAATGGAAATGAAAGGAGAGCCGAAAGAC
AAAGTAGAAAAAATAGGATTAGTTGAAGATCTAAATAAAGGAGCTAAGCCTGTAGTTGTGCTACAAAAACTGTCTTTGGATGATGTTCAG
AAACTTATTAAAGATAGAGAGGACAAATCAAGAAGTTCCCTTAAACCTATCAAGAATAAACCATCAAAGTCAAATAAAGGTAGTATAGAT
CAATCAGTGTTAAAAGAATTACCCCCTGAACTCCTGGCAGAAATTGAGTCCACCATGCCACTTTGTGAACGTGTGAAAATGAACAAACGC
AAGCGTAGCACAGTTAATGAAAAGCCAAAATATGCTGAAATCAGTTCAGATGAAGATAATGATAGTGATGAAGCTTTTGAATCCTCTAGG
AAACGACATAAAAAAGATGATGATAAAGCTTGGGAATATGAAGAGCGTGACAGAAGAAGCTCTGGGGATCATAGGAGAAGTGGCCACTCT
CATGAAGGAAGAAGGAGTTCAGGTGGTGGTCGTTATCGAAACCGAAGTCCGTCAGATTCTGACATGGAAGATTATTCTCCTCCTCCCAGC
CTTAGTGAGGTTGCTAGGAAAATGAAGAAAAAAGAAAAACAGAAGAAAAGGAAAGCATATGAACCAAAACTAACACCTGAAGAAATGATG
GACTCTTCAACTTTTAAGAGATTCACAGCCTCAATAGAGAATATTTTGGATAATTTGGAAGATATGGATTTTACTGCGTTTGGTGATGAT
GATGAAATTCCTCAGGAACTGCTCTTAGGAAAACATCAGCTTAATGAACTTGGCAGTGAATCTGCTAAAATAAAAGCAATGGGTATAATG
GATAAGCTTTCAACTGACAAAACTGTGAAAGTCTTAAATATCTTGGAGAAGAATATTCAGGATGGGTCAAAGCTTTCCACTTTGTTAAAT
CATAATAACGATACTGAAGAAGAAGAAAGGTTATGGAGAGACCTTATTATGGAGAGAGTTACAAAATCAGCGGATGCTTGTCTTACAACT
ATCAACATTATGACATCCCCTAACATGCCAAAAGCTGTGTACATTGAGGATGTAATTGAAAGAGTTATACAGTACACTAAATTTCATTTG
CAGAATACACTTTATCCTCAGTATGATCCTGTTTACAGATTAGATCCTCATGGAGGAGGCTTATTAAGTTCAAAAGCAAAACGGGCTAAA
TGTTCTACCCATAAGCAGAGAGTAATAGTAATGCTTTATAACAAAGTTTGTGACATTGTTAGCAGCTTATCAGAATTGCTAGAGATACAA
CTTCTTACAGACACAACAATTCTTCAGGTTTCATCTATGGGAATAACACCATTTTTTGTGGAAAATGTCAGTGAACTACAGTTGTGTGCC
ATTAAGTTAGTCACTGCAGTATTCTCAAGATATGAAAAACATAGGCAGTTAATTTTGGAAGAAATTTTTACTTCACTTGCAAGATTACCA
ACCAGCAAGAGGAGTTTAAGGAACTTCAGGTTAAACAGTAGTGATATGGATGGAGAACCTATGTATATTCAGATGGTTACAGCACTGGTT
TTACAACTTATTCAGTGTGTGGTACACTTACCATCATCAGAGAAGGACTCTAATGCAGAAGAAGATTCAAATAAAAAAGGAACACGGGTC
TGGCTGAGAGAAAATGGCCAGCATTTTCCAAGTACTGTAAATTCCTGTGCAGAAGGCATCGTCGTCTTCCGGACAGACTATGGTCAGGTA
TTCACTTACAAGCAGAGCACAATTACCCACCAGAAGGTGACTGCTATGCACCCCACGAACGAGGAGGGCGTGGATGACATGGCGTCCTTG
ACAGAGCTCCATGGCGGCTCCATCATGTATAACTTATTCCAGCGGTATAAGAGAAATCAAATATATACCTACATCGGCTCCATCCTGGCC
TCCGTGAACCCCTACCAGCCCATCGCCGGGCTGTACGAGCCTGCCACCATGGAGCAGTACAGCCGGCGCCACCTGGGCGAGCTGCCCCCG
CACATCTTCGCCATCGCCAACGAGTGCTACCGCTGCCTGTGGAAGCGCCACGACAACCAGTGCATCCTCATCAGTGGTGAAAGTGGGGCA
GGTAAAACCGAAAGCACTAAATTGATCCTCAAGTTTCTGTCAGTCATCAGTCAACAGTCTTTGGAATTGTCCTTAAAGGAGAAGACATCC
TGTGTTGAACGAGCTATTCTTGAAAGCAGCCCCATCATGGAAGCTTTCGGCAATGCGAAGACCGTGTACAACAACAACTCTAGTCGCTTT
GGGAAGTTTGTTCAGCTGAACATCTGTCAGAAAGGAAATATTCAGGGCGGGAGAATTGTAGATTATTTATTAGAAAAAAACCGAGTAGTA
AGGCAAAATCCCGGGGAAAGGAATTATCACATATTTTATGCACTGCTGGCAGGGCTGGAACATGAAGAAAGAGAAGAATTTTATTTATCT
ACGCCAGAAAACTACCACTACTTGAATCAGTCTGGATGTGTAGAAGACAAGACAATCAGTGACCAGGAATCCTTTAGGGAAGTTATTACG
GCAATGGACGTGATGCAGTTCAGCAAGGAGGAAGTTCGGGAAGTGTCGAGGCTGCTTGCTGGTATACTGCATCTTGGGAACATAGAATTT
ATCACTGCTGGTGGGGCACAGGTTTCCTTCAAAACAGCTTTGGGCAGATCTGCGGAGTTACTTGGGCTGGACCCAACACAGCTCACAGAT
GCTTTGACCCAGAGATCAATGTTCCTCAGGGGAGAAGAGATCCTCACGCCTCTCAATGTTCAACAGGCAGTAGACAGCAGGGACTCCCTG
GCCATGGCTCTGTATGCGTGCTGCTTTGAGTGGGTAATCAAGAAGATCAACAGCAGGATCAAAGGCAATGAGGACTTCAAGTCTATTGGC
ATCCTCGACATCTTTGGATTTGAAAACTTTGAGGTTAATCACTTTGAACAGTTCAATATAAACTATGCAAACGAGAAACTTCAGGAGTAC
TTCAACAAGCATATTTTTTCTTTAGAACAACTAGAATATAGCCGGGAAGGATTAGTGTGGGAAGATATTGACTGGATAGACAATGGAGAA
TGCCTGGACTTGATTGAGAAGAAACTTGGCCTCCTAGCCCTTATCAATGAAGAAAGCCATTTTCCTCAAGCCACAGACAGCACCTTATTG
GAGAAGCTACACAGTCAGCATGCGAATAACCACTTTTATGTGAAGCCCAGAGTTGCAGTTAACAATTTTGGAGTGAAGCACTATGCTGGA
GAGGTGCAATATGATGTCCGAGGTATCTTGGAGAAGAACAGAGATACATTTCGAGATGACCTTCTCAATTTGCTAAGAGAAAGCCGATTT
GACTTTATCTACGATCTTTTTGAACATGTTTCAAGCCGCAACAACCAGGATACCTTGAAATGTGGAAGCAAACATCGGCGGCCTACAGTC
AGCTCACAGTTCAAGGACTCACTGCATTCCTTAATGGCAACGCTAAGCTCCTCTAATCCTTTCTTTGTTCGCTGTATCAAGCCAAACATG
CAGAAGATGCCAGACCAGTTTGACCAGGCGGTTGTGCTGAACCAGCTGCGGTACTCAGGGATGCTGGAGACTGTGAGAATCCGCAAAGCT
GGGTATGCGGTCCGAAGACCCTTTCAGGACTTTTACAAAAGGTATAAAGTGCTGATGAGGAATCTGGCTCTGCCTGAGGACGTCCGAGGG
AAGTGCACGAGCCTGCTGCAGCTCTATGATGCCTCCAACAGCGAGTGGCAGCTGGGGAAGACCAAGGTCTTTCTTCGAGAATCCTTGGAA
CAGAAACTGGAGAAGCGGAGGGAAGAGGAAGTGAGCCACGCGGCCATGGTGATTCGGGCCCATGTCTTGGGCTTCTTAGCACGAAAACAA
TACAGAAAGGTCCTTTATTGTGTGGTGATAATACAGAAGAATTACAGAGCATTCCTTCTGAGGAGGAGATTTTTGCACCTGAAAAAGGCA
GCCATAGTTTTCCAGAAGCAACTCAGAGGTCAGATTGCTCGGAGAGTTTACAGACAATTGCTGGCAGAGAAAAGGGAGCAAGAAGAAAAG
AAGAAACAGGAAGAGGAAGAAAAGAAGAAACGGGAGGAAGAAGAAAGAGAAAGAGAGAGAGAGCGAAGAGAAGCCGAGCTCCGCGCCCAG
CAGGAAGAAGAAACGAGGAAGCAGCAAGAACTCGAAGCCTTGCAGAAGAGCCAGAAGGAAGCTGAACTGACCCGTGAACTGGAGAAACAG
AAGGAAAATAAGCAGGTGGAAGAGATCCTCCGTCTGGAGAAAGAAATCGAGGACCTGCAGCGCATGAAGGAGCAGCAGGAGCTGTCGCTG
ACCGAGGCTTCCCTGCAGAAGCTGCAGGAGCGGCGGGACCAGGAGCTCCGCAGGCTGGAGGAGGAAGCGTGCAGGGCGGCCCAGGAGTTC
CTCGAGTCCCTCAATTTCGACGAGATCGACGAGTGTGTCCGGAATATCGAGCGGTCCCTGTCGGTGGGAAGCGAATTTTCCAGCGAGCTG
GCTGAGAGCGCATGCGAGGAGAAGCCCAACTTCAACTTCAGCCAGCCCTACCCAGAGGAGGAGGTCGATGAGGGCTTCGAAGCCGACGAC
GACGCCTTCAAGGACTCCCCCAACCCCAGCGAGCACGGCCACTCAGACCAGCGAACAAGTGGCATCCGGACCAGCGATGACTCTTCAGAG
GAGGACCCATACATGAACGACACGGTGGTGCCCACCAGCCCCAGTGCGGACAGCACGGTGCTGCTCGCCCCATCAGTGCAGGACTCCGGG
AGCCTACACAACTCCTCCAGCGGCGAGTCCACCTACTGCATGCCCCAGAACGCTGGGGACTTGCCCTCCCCAGACGGCGACTACGACTAC
GACCAGGATGACTATGAGGACGGTGCCATCACTTCCGGCAGCAGCGTGACCTTCTCCAACTCCTACGGCAGCCAGTGGTCCCCCGACTAC
CGCTGCTCTGTGGGGACCTACAACAGCTCGGGTGCCTACCGGTTCAGCTCTGAGGGGGCGCAGTCCTCGTTTGAAGATAGTGAAGAGGAC
TTTGATTCCAGGTTTGATACAGATGATGAGCTTTCATACCGGCGTGACTCTGTGTACAGCTGTGTCACTCTGCCGTATTTCCACAGCTTT
CTGTACATGAAAGGTGGCCTGATGAACTCTTGGAAACGCCGCTGGTGCGTCCTCAAGGATGAAACCTTCTTGTGGTTCCGCTCCAAGCAG
GAGGCCCTCAAGCAAGGCTGGCTCCACAAAAAAGGGGGGGGCTCCTCCACGCTGTCCAGGAGAAATTGGAAGAAGCGCTGGTTTGTCCTC
CGCCAGTCCAAGCTGATGTACTTTGAAAACGACAGCGAGGAGAAGCTCAAGGGCACCGTAGAAGTGCGAACGGCAAAAGAGATCATAGAT
AACACCACCAAGGAGAATGGGATCGACATCATTATGGCCGATAGGACTTTCCACCTGATTGCAGAGTCCCCAGAAGATGCCAGCCAGTGG
TTCAGCGTGCTGAGTCAGGTCCACGCGTCCACGGACCAGGAGATCCAGGAGATGCATGATGAGCAGGCAAACCCACAGAATGCTGTGGGC
ACCTTGGATGTGGGGCTGATTGATTCTGTGTGTGCCTCTGACAGCCCTGATAGACCCAACTCGTTTGTGATCATCACGGCCAACCGGGTG
CTGCACTGCAACGCCGACACGCCGGAGGAGATGCACCACTGGATAACCCTGCTGCAGAGGTCCAAAGGGGACACCAGAGTGGAGGGCCAG
GAATTCATCGTGAGAGGATGGTTGCACAAAGAGGTGAAGAACAGTCCAAAGATGTCTTCACTGAAACTGAAGAAACGGTGGTTTGTACTC
ACCCACAATTCCCTGGATTACTACAAGAGTTCAGAGAAGAACGCGCTCAAACTGGGGACCCTGGTCCTCAACAGCCTCTGCTCTGTCGTC
CCCCCAGATGAGAAGATATTCAAAGAGACAGGCTACTGGAACGTCACCGTGTACGGGCGCAAGCACTGTTACCGGCTCTACACCAAGCTG
CTCAACGAGGCCACCCGGTGGTCCAGTGCCATTCAAAACGTGACTGACACCAAGGCCCCGATCGACACCCCCACCCAGCAGCTGATTCAA
GATATCAAGGAGAACTGCCTGAACTCGGATGTGGTGGAACAGATTTACAAGCGGAACCCGATCCTTCGATACACCCATCACCCCTTGCAC
TCCCCGCTCCTGCCCCTTCCGTATGGGGACATAAATCTCAACTTGCTCAAAGACAAAGGCTATACCACCCTTCAGGATGAGGCCATCAAG
ATATTCAATTCCCTGCAGCAACTGGAGTCCATGTCTGACCCAATTCCAATAATCCAGGGCATCCTACAGACAGGGCATGACCTGCGACCT
CTGCGGGACGAGCTGTACTGCCAGCTTATCAAACAGACCAACAAAGTGCCCCACCCCGGCAGTGTGGGCAACCTGTACAGCTGGCAGATC
CTGACATGCCTGAGCTGCACCTTCCTGCCGAGTCGAGGGATTCTCAAGTATCTCAAGTTCCATCTGAAAAGGATACGGGAACAGTTTCCA
GGAAGCGAGATGGAAAAATACGCTCTCTTCACTTACGAATCTCTTAAGAAAACCAAATGCCGAGAGTTTGTGCCTTCCCGAGATGAAATA
GAAGCTCTGATCCACAGGCAGGAAATGACATCCACGGTCTATTGCCATGGCGGCGGCTCCTGCAAGATCACCATCAACTCCCACACCACC
GCTGGGGAGGTGGTGGAGAAGCTGATCCGAGGCCTGGCCATGGAGGACAGCAGGAACATGTTTGCTTTGTTTGAATACAACGGCCACGTC
GACAAAGCCATTGAAAGTCGAACCGTCGTAGCTGATGTCTTAGCCAAGTTTGAAAAGCTGGCTGCCACATCCGAGGTTGGGGACCTGCCA
TGGAAATTCTACTTCAAACTTTACTGCTTCCTGGACACAGACAACGTGCCAAAAGACAGTGTGGAGTTTGCATTTATGTTTGAACAGGCC
CACGAAGCGGTTATCCATGGCCACCATCCAGCCCCGGAAGAAAACCTCCAGGTTCTTGCTGCCCTGCGACTCCAGTATCTGCAGGGGGAT
TATACTCTGCACGCTGCCATCCCACCTCTCGAAGAGGTTTATTCCCTGCAGAGACTCAAGGCCCGCATCAGCCAGTCAACCAAAACCTTC
ACCCCTTGTGAACGGCTGGAGAAGAGGCGGACGAGCTTCCTAGAGGGGACCCTGAGGCGGAGCTTCCGGACAGGATCCGTGGTCCGGCAG
AAGGTCGAGGAGGAGCAGATGCTGGACATGTGGATTAAGGAAGAAGTCTCCTCTGCTCGAGCCAGTATCATTGACAAGTGGAGGAAATTT
CAGGGAATGAACCAGGAACAGGCCATGGCCAAGTACATGGCCTTGATCAAGGAGTGGCCTGGCTATGGCTCGACGCTGTTTGATGTGGAG
TGCAAGGAAGGTGGCTTCCCTCAGGAACTCTGGTTGGGTGTCAGCGCGGACGCCGTCTCCGTCTACAAGCGTGGAGAGGGAAGACCACTG
GAAGTCTTCCAGTATGAACACATCCTCTCTTTTGGGGCACCCCTGGCGAATACGTATAAGATCGTGGTCGATGAGAGGGAGCTGCTCTTT
GAAACCAGTGAGGTGGTGGATGTGGCCAAGCTCATGAAAGCCTACATCAGCATGATCGTGAAGAAGCGCTACAGCACGACACGCTCCGCC
AGCAGCCAGGGCAGCTCCAGGTGAAGGCGGGACAGAGCCCACCTGTCTTTGCTACCTGAACGCACCACCCTCTGGCCTAGGCTGGCTCCA
GTGTGCCATGCCCAGCCAAAACAAACACAGAGCTGCCCAGGCTTTCTGGAAGCTTCTGGTCTGAGGGAGGTGTCTCCGAGGATCCTTTTG
CCTGCCGCCTTCATTGATCCTGTATTAAGCTGTCAACTTTAACAGTCTGCACAGTTTCCAAAGCTTTACTACTCTTAGAGGACACATGCC
TTAAAAAAGGAGGGGAGGAACCACGCTGCCACCAAAGCAGCCGGAAGTGCCTTAACTTGTGGAACCAACACTAATCGACCGTAACTGTGC
TACTGAAGGGAACTGCCTTTCCCCCTTCTGGGGGAGACTTAACAGAGCGTGGAAGGGGGGCATTCTCTGTCAATGATGCACTAACCTCCC
AACCTGATTTCCCCGAATCTGAGGGAAGGTGAGGGAGTGGGAAGGGGGATGGAGAGCTCGAGGGGACAGTGTGTTTGAGCTGGAGTGCTG
CGGGCAGCCTTTCTCATGGAATGACATGAATCAACTTTTTTCTTTGTTTCATCTTTTAAGTGTACGTGCTTGCCTGTTCGTGCATGTGTT
CATAAACTCAACACTTTAATCATGGTTTCATGAGCATTAAAAAGCAAAGGGAAAAAGGATGTGTAATGGTGTACACAGTCTGTATATTTT
AATAATGCAGAGCTATAGTCTCAATTGTTACTTTATAAGGTGGTTTTATTAACAAACCCAAATCCTGGATTTTCCTGTCTTTGCTGTATT
TTGAAAAACACGTGTTGACTCCATTGTTTTACATGTAGCAAAGTCTGCCATCTGTGTCTGCTGTATTATAAACAGATAAGCAGCCTACAA
GATAACTGTATTTATAAACCACTCTTCAACAGCTGGCTCCAGTGCTGGTTTTAGAACAAGAATGAAGTCATTTTGGAGTCTTTCATGTCT
AAAAGATTTAAGTTAAAAACAAAGTGTTACTTGGAAGGTTAGCTTCTATCATTCTGGATAGATTACAGATATAATAACCATGTTGACTAT
GGGGGAGAGACGCTGCATTCCAGAAACGTCTTAACACTTGAGTGAATCTTCAAAGGACCCTGACATTAAATGCTGAGGCTTTAATACACA
CATATTTTATCCCAAGTTTATAATGGTGGTCTGAACAAGGCACCTGTAAATAAATCAGCATTTATGACCAGAAGAAAAATAATCTGGTCT
TGGACTTTTTATTTTTATATGGAAAAGTTTTAAGGACTTGGGCCAACTAAGTCTACCCACACGAAAAAAGAAATTTGCCTTGTCCCTTTG

>59206_59206_4_NIPBL-MYO10_NIPBL_chr5_37010327_ENST00000448238_MYO10_chr5_16877816_ENST00000513610_length(amino acids)=3571AA_BP=1520
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASF
PLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTL
RLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQT
SVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM
VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRL
VETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG
HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSV
SESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS
NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIG
LVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVN
EKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVAR
KMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTD
KTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERVIQYTKFHLQNTLYP
QYDPVYRLDPHGGGLLSSKAKRAKCSTHKQRVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA
VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQCVVHLPSSEKDSNAEEDSNKKGTRVWLRENG
QHFPSTVNSCAEGIVVFRTDYGQVFTYKQSTITHQKVTAMHPTNEEGVDDMASLTELHGGSIMYNLFQRYKRNQIYTYIGSILASVNPYQ
PIAGLYEPATMEQYSRRHLGELPPHIFAIANECYRCLWKRHDNQCILISGESGAGKTESTKLILKFLSVISQQSLELSLKEKTSCVERAI
LESSPIMEAFGNAKTVYNNNSSRFGKFVQLNICQKGNIQGGRIVDYLLEKNRVVRQNPGERNYHIFYALLAGLEHEEREEFYLSTPENYH
YLNQSGCVEDKTISDQESFREVITAMDVMQFSKEEVREVSRLLAGILHLGNIEFITAGGAQVSFKTALGRSAELLGLDPTQLTDALTQRS
MFLRGEEILTPLNVQQAVDSRDSLAMALYACCFEWVIKKINSRIKGNEDFKSIGILDIFGFENFEVNHFEQFNINYANEKLQEYFNKHIF
SLEQLEYSREGLVWEDIDWIDNGECLDLIEKKLGLLALINEESHFPQATDSTLLEKLHSQHANNHFYVKPRVAVNNFGVKHYAGEVQYDV
RGILEKNRDTFRDDLLNLLRESRFDFIYDLFEHVSSRNNQDTLKCGSKHRRPTVSSQFKDSLHSLMATLSSSNPFFVRCIKPNMQKMPDQ
FDQAVVLNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRYKVLMRNLALPEDVRGKCTSLLQLYDASNSEWQLGKTKVFLRESLEQKLEKR
REEEVSHAAMVIRAHVLGFLARKQYRKVLYCVVIIQKNYRAFLLRRRFLHLKKAAIVFQKQLRGQIARRVYRQLLAEKREQEEKKKQEEE
EKKKREEEERERERERREAELRAQQEEETRKQQELEALQKSQKEAELTRELEKQKENKQVEEILRLEKEIEDLQRMKEQQELSLTEASLQ
KLQERRDQELRRLEEEACRAAQEFLESLNFDEIDECVRNIERSLSVGSEFSSELAESACEEKPNFNFSQPYPEEEVDEGFEADDDAFKDS
PNPSEHGHSDQRTSGIRTSDDSSEEDPYMNDTVVPTSPSADSTVLLAPSVQDSGSLHNSSSGESTYCMPQNAGDLPSPDGDYDYDQDDYE
DGAITSGSSVTFSNSYGSQWSPDYRCSVGTYNSSGAYRFSSEGAQSSFEDSEEDFDSRFDTDDELSYRRDSVYSCVTLPYFHSFLYMKGG
LMNSWKRRWCVLKDETFLWFRSKQEALKQGWLHKKGGGSSTLSRRNWKKRWFVLRQSKLMYFENDSEEKLKGTVEVRTAKEIIDNTTKEN
GIDIIMADRTFHLIAESPEDASQWFSVLSQVHASTDQEIQEMHDEQANPQNAVGTLDVGLIDSVCASDSPDRPNSFVIITANRVLHCNAD
TPEEMHHWITLLQRSKGDTRVEGQEFIVRGWLHKEVKNSPKMSSLKLKKRWFVLTHNSLDYYKSSEKNALKLGTLVLNSLCSVVPPDEKI
FKETGYWNVTVYGRKHCYRLYTKLLNEATRWSSAIQNVTDTKAPIDTPTQQLIQDIKENCLNSDVVEQIYKRNPILRYTHHPLHSPLLPL
PYGDINLNLLKDKGYTTLQDEAIKIFNSLQQLESMSDPIPIIQGILQTGHDLRPLRDELYCQLIKQTNKVPHPGSVGNLYSWQILTCLSC
TFLPSRGILKYLKFHLKRIREQFPGSEMEKYALFTYESLKKTKCREFVPSRDEIEALIHRQEMTSTVYCHGGGSCKITINSHTTAGEVVE
KLIRGLAMEDSRNMFALFEYNGHVDKAIESRTVVADVLAKFEKLAATSEVGDLPWKFYFKLYCFLDTDNVPKDSVEFAFMFEQAHEAVIH
GHHPAPEENLQVLAALRLQYLQGDYTLHAAIPPLEEVYSLQRLKARISQSTKTFTPCERLEKRRTSFLEGTLRRSFRTGSVVRQKVEEEQ
MLDMWIKEEVSSARASIIDKWRKFQGMNQEQAMAKYMALIKEWPGYGSTLFDVECKEGGFPQELWLGVSADAVSVYKRGEGRPLEVFQYE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NIPBL-MYO10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NIPBL-MYO10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NIPBL-MYO10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource