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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NIPBL-WDR70 (FusionGDB2 ID:59215)

Fusion Gene Summary for NIPBL-WDR70

check button Fusion gene summary
Fusion gene informationFusion gene name: NIPBL-WDR70
Fusion gene ID: 59215
HgeneTgene
Gene symbol

NIPBL

WDR70

Gene ID

25836

55100

Gene nameNIPBL cohesin loading factorWD repeat domain 70
SynonymsCDLS|CDLS1|IDN3|IDN3-B|Scc2-
Cytomap

5p13.2

5p13.2

Type of geneprotein-codingprotein-coding
Descriptionnipped-B-like proteinNipped-B homologSCC2 homologdelanginsister chromatid cohesion 2 homologWD repeat-containing protein 70
Modification date2020031320200313
UniProtAcc

Q6KC79

.
Ensembl transtripts involved in fusion geneENST00000282516, ENST00000448238, 
ENST00000504430, 		ENST00000504564, 
ENST00000510699, ENST00000265107, 
Fusion gene scores* DoF score26 X 13 X 16=540810 X 12 X 11=1320
# samples 4316
** MAII scorelog2(43/5408*10)=-3.65268658669272
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1320*10)=-3.04439411935845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NIPBL [Title/Abstract] AND WDR70 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNIPBL(36877280)-WDR70(37697756), # samples:1
NIPBL(36877280)-WDR70(37438023), # samples:1
NIPBL(37061120)-WDR70(37752587), # samples:1
NIPBL(36877280)-WDR70(37379591), # samples:1
NIPBL(36877280)-WDR70(37697757), # samples:1
NIPBL(36877280)-WDR70(37438024), # samples:1
NIPBL(37061120)-WDR70(37438024), # samples:1
NIPBL(37061120)-WDR70(37752588), # samples:1
Anticipated loss of major functional domain due to fusion event.NIPBL-WDR70 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
NIPBL-WDR70 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NIPBL-WDR70 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNIPBL

GO:0000122

negative regulation of transcription by RNA polymerase II

18854353

HgeneNIPBL

GO:0031065

positive regulation of histone deacetylation

18854353

HgeneNIPBL

GO:0045892

negative regulation of transcription, DNA-templated

18854353

HgeneNIPBL

GO:0071921

cohesin loading

22628566


check buttonFusion gene breakpoints across NIPBL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across WDR70 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-G2-A2EF-01ANIPBLchr5

36877280

+WDR70chr5

37379591

+
ChimerDB4CESCTCGA-LP-A4AX-01ANIPBLchr5

36877280

+WDR70chr5

37697757

+
ChimerDB4CESCTCGA-LP-A4AXNIPBLchr5

36877280

+WDR70chr5

37697756

+
ChimerDB4ESCATCGA-LN-A4A5NIPBLchr5

36877280

+WDR70chr5

37438023

+
ChimerDB4ESCATCGA-LN-A4A5NIPBLchr5

36877280

+WDR70chr5

37438024

+
ChimerDB4HNSCTCGA-QK-A6VCNIPBLchr5

37061120

+WDR70chr5

37438024

+
ChimerDB4STADTCGA-D7-6822-01ANIPBLchr5

37061120

+WDR70chr5

37752588

+
ChimerDB4STADTCGA-D7-6822NIPBLchr5

37061120

+WDR70chr5

37752587

+


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Fusion Gene ORF analysis for NIPBL-WDR70

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000282516ENST00000504564NIPBLchr5

37061120

+WDR70chr5

37752588

+
5CDS-intronENST00000282516ENST00000504564NIPBLchr5

37061120

+WDR70chr5

37752587

+
5CDS-intronENST00000282516ENST00000510699NIPBLchr5

37061120

+WDR70chr5

37438024

+
5CDS-intronENST00000282516ENST00000510699NIPBLchr5

37061120

+WDR70chr5

37752588

+
5CDS-intronENST00000282516ENST00000510699NIPBLchr5

37061120

+WDR70chr5

37752587

+
5CDS-intronENST00000448238ENST00000504564NIPBLchr5

37061120

+WDR70chr5

37752588

+
5CDS-intronENST00000448238ENST00000504564NIPBLchr5

37061120

+WDR70chr5

37752587

+
5CDS-intronENST00000448238ENST00000510699NIPBLchr5

37061120

+WDR70chr5

37438024

+
5CDS-intronENST00000448238ENST00000510699NIPBLchr5

37061120

+WDR70chr5

37752588

+
5CDS-intronENST00000448238ENST00000510699NIPBLchr5

37061120

+WDR70chr5

37752587

+
5UTR-3CDSENST00000282516ENST00000265107NIPBLchr5

36877280

+WDR70chr5

37379591

+
5UTR-3CDSENST00000282516ENST00000265107NIPBLchr5

36877280

+WDR70chr5

37697757

+
5UTR-3CDSENST00000282516ENST00000265107NIPBLchr5

36877280

+WDR70chr5

37697756

+
5UTR-3CDSENST00000282516ENST00000265107NIPBLchr5

36877280

+WDR70chr5

37438023

+
5UTR-3CDSENST00000282516ENST00000265107NIPBLchr5

36877280

+WDR70chr5

37438024

+
5UTR-3CDSENST00000282516ENST00000504564NIPBLchr5

36877280

+WDR70chr5

37379591

+
5UTR-3CDSENST00000282516ENST00000504564NIPBLchr5

36877280

+WDR70chr5

37438023

+
5UTR-3CDSENST00000282516ENST00000504564NIPBLchr5

36877280

+WDR70chr5

37438024

+
5UTR-3CDSENST00000448238ENST00000265107NIPBLchr5

36877280

+WDR70chr5

37379591

+
5UTR-3CDSENST00000448238ENST00000265107NIPBLchr5

36877280

+WDR70chr5

37697757

+
5UTR-3CDSENST00000448238ENST00000265107NIPBLchr5

36877280

+WDR70chr5

37697756

+
5UTR-3CDSENST00000448238ENST00000265107NIPBLchr5

36877280

+WDR70chr5

37438023

+
5UTR-3CDSENST00000448238ENST00000265107NIPBLchr5

36877280

+WDR70chr5

37438024

+
5UTR-3CDSENST00000448238ENST00000504564NIPBLchr5

36877280

+WDR70chr5

37379591

+
5UTR-3CDSENST00000448238ENST00000504564NIPBLchr5

36877280

+WDR70chr5

37438023

+
5UTR-3CDSENST00000448238ENST00000504564NIPBLchr5

36877280

+WDR70chr5

37438024

+
5UTR-3UTRENST00000282516ENST00000504564NIPBLchr5

36877280

+WDR70chr5

37697757

+
5UTR-3UTRENST00000282516ENST00000504564NIPBLchr5

36877280

+WDR70chr5

37697756

+
5UTR-3UTRENST00000282516ENST00000510699NIPBLchr5

36877280

+WDR70chr5

37697757

+
5UTR-3UTRENST00000282516ENST00000510699NIPBLchr5

36877280

+WDR70chr5

37697756

+
5UTR-3UTRENST00000448238ENST00000504564NIPBLchr5

36877280

+WDR70chr5

37697757

+
5UTR-3UTRENST00000448238ENST00000504564NIPBLchr5

36877280

+WDR70chr5

37697756

+
5UTR-3UTRENST00000448238ENST00000510699NIPBLchr5

36877280

+WDR70chr5

37697757

+
5UTR-3UTRENST00000448238ENST00000510699NIPBLchr5

36877280

+WDR70chr5

37697756

+
5UTR-intronENST00000282516ENST00000510699NIPBLchr5

36877280

+WDR70chr5

37379591

+
5UTR-intronENST00000282516ENST00000510699NIPBLchr5

36877280

+WDR70chr5

37438023

+
5UTR-intronENST00000282516ENST00000510699NIPBLchr5

36877280

+WDR70chr5

37438024

+
5UTR-intronENST00000448238ENST00000510699NIPBLchr5

36877280

+WDR70chr5

37379591

+
5UTR-intronENST00000448238ENST00000510699NIPBLchr5

36877280

+WDR70chr5

37438023

+
5UTR-intronENST00000448238ENST00000510699NIPBLchr5

36877280

+WDR70chr5

37438024

+
Frame-shiftENST00000282516ENST00000265107NIPBLchr5

37061120

+WDR70chr5

37752588

+
Frame-shiftENST00000282516ENST00000265107NIPBLchr5

37061120

+WDR70chr5

37752587

+
Frame-shiftENST00000448238ENST00000265107NIPBLchr5

37061120

+WDR70chr5

37752588

+
Frame-shiftENST00000448238ENST00000265107NIPBLchr5

37061120

+WDR70chr5

37752587

+
In-frameENST00000282516ENST00000265107NIPBLchr5

37061120

+WDR70chr5

37438024

+
In-frameENST00000282516ENST00000504564NIPBLchr5

37061120

+WDR70chr5

37438024

+
In-frameENST00000448238ENST00000265107NIPBLchr5

37061120

+WDR70chr5

37438024

+
In-frameENST00000448238ENST00000504564NIPBLchr5

37061120

+WDR70chr5

37438024

+
intron-3CDSENST00000504430ENST00000265107NIPBLchr5

36877280

+WDR70chr5

37379591

+
intron-3CDSENST00000504430ENST00000265107NIPBLchr5

36877280

+WDR70chr5

37697757

+
intron-3CDSENST00000504430ENST00000265107NIPBLchr5

36877280

+WDR70chr5

37697756

+
intron-3CDSENST00000504430ENST00000265107NIPBLchr5

36877280

+WDR70chr5

37438023

+
intron-3CDSENST00000504430ENST00000265107NIPBLchr5

36877280

+WDR70chr5

37438024

+
intron-3CDSENST00000504430ENST00000265107NIPBLchr5

37061120

+WDR70chr5

37438024

+
intron-3CDSENST00000504430ENST00000265107NIPBLchr5

37061120

+WDR70chr5

37752588

+
intron-3CDSENST00000504430ENST00000265107NIPBLchr5

37061120

+WDR70chr5

37752587

+
intron-3CDSENST00000504430ENST00000504564NIPBLchr5

36877280

+WDR70chr5

37379591

+
intron-3CDSENST00000504430ENST00000504564NIPBLchr5

36877280

+WDR70chr5

37438023

+
intron-3CDSENST00000504430ENST00000504564NIPBLchr5

36877280

+WDR70chr5

37438024

+
intron-3CDSENST00000504430ENST00000504564NIPBLchr5

37061120

+WDR70chr5

37438024

+
intron-3UTRENST00000504430ENST00000504564NIPBLchr5

36877280

+WDR70chr5

37697757

+
intron-3UTRENST00000504430ENST00000504564NIPBLchr5

36877280

+WDR70chr5

37697756

+
intron-3UTRENST00000504430ENST00000510699NIPBLchr5

36877280

+WDR70chr5

37697757

+
intron-3UTRENST00000504430ENST00000510699NIPBLchr5

36877280

+WDR70chr5

37697756

+
intron-intronENST00000504430ENST00000504564NIPBLchr5

37061120

+WDR70chr5

37752588

+
intron-intronENST00000504430ENST00000504564NIPBLchr5

37061120

+WDR70chr5

37752587

+
intron-intronENST00000504430ENST00000510699NIPBLchr5

36877280

+WDR70chr5

37379591

+
intron-intronENST00000504430ENST00000510699NIPBLchr5

36877280

+WDR70chr5

37438023

+
intron-intronENST00000504430ENST00000510699NIPBLchr5

36877280

+WDR70chr5

37438024

+
intron-intronENST00000504430ENST00000510699NIPBLchr5

37061120

+WDR70chr5

37438024

+
intron-intronENST00000504430ENST00000510699NIPBLchr5

37061120

+WDR70chr5

37752588

+
intron-intronENST00000504430ENST00000510699NIPBLchr5

37061120

+WDR70chr5

37752587

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000282516NIPBLchr537061120+ENST00000265107WDR70chr537438024+10694835949998313110
ENST00000282516NIPBLchr537061120+ENST00000504564WDR70chr537438024+9310835949990302843
ENST00000448238NIPBLchr537061120+ENST00000265107WDR70chr537438024+10663832846898003110
ENST00000448238NIPBLchr537061120+ENST00000504564WDR70chr537438024+9279832846889992843

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000282516ENST00000265107NIPBLchr537061120+WDR70chr537438024+0.0006001870.9993998
ENST00000282516ENST00000504564NIPBLchr537061120+WDR70chr537438024+0.0004167820.9995832
ENST00000448238ENST00000265107NIPBLchr537061120+WDR70chr537438024+0.0005916040.99940836
ENST00000448238ENST00000504564NIPBLchr537061120+WDR70chr537438024+0.0004123990.9995876

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Fusion Genomic Features for NIPBL-WDR70


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NIPBLchr537061120+WDR70chr537752587+7.55E-050.99992454
NIPBLchr537061120+WDR70chr537752587+7.55E-050.99992454
NIPBLchr536877280+WDR70chr537697756+2.17E-050.9999783
NIPBLchr536877280+WDR70chr537697756+2.17E-050.9999783
NIPBLchr537061120+WDR70chr537438023+9.48E-060.99999046
NIPBLchr536877280+WDR70chr537379590+2.43E-060.9999976
NIPBLchr536877280+WDR70chr537438023+1.35E-060.9999987
NIPBLchr537061120+WDR70chr537752587+7.55E-050.99992454
NIPBLchr537061120+WDR70chr537752587+7.55E-050.99992454
NIPBLchr536877280+WDR70chr537697756+2.17E-050.9999783
NIPBLchr536877280+WDR70chr537697756+2.17E-050.9999783
NIPBLchr537061120+WDR70chr537438023+9.48E-060.99999046
NIPBLchr536877280+WDR70chr537379590+2.43E-060.9999976
NIPBLchr536877280+WDR70chr537438023+1.35E-060.9999987

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NIPBL-WDR70


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:36877280/chr5:37697756)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NIPBL

Q6KC79

.
FUNCTION: Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNIPBLchr5:37061120chr5:37438024ENST00000282516+4547418_46226202805.0Compositional biasNote=Gln-rich
HgeneNIPBLchr5:37061120chr5:37438024ENST00000448238+4546418_46226202698.0Compositional biasNote=Gln-rich
HgeneNIPBLchr5:37061120chr5:37438024ENST00000282516+4547996_100926202805.0MotifPxVxL motif
HgeneNIPBLchr5:37061120chr5:37438024ENST00000448238+4546996_100926202698.0MotifPxVxL motif
HgeneNIPBLchr5:37061120chr5:37438024ENST00000282516+45471767_180526202805.0RepeatNote=HEAT 1
HgeneNIPBLchr5:37061120chr5:37438024ENST00000282516+45471843_188126202805.0RepeatNote=HEAT 2
HgeneNIPBLchr5:37061120chr5:37438024ENST00000282516+45471945_198426202805.0RepeatNote=HEAT 3
HgeneNIPBLchr5:37061120chr5:37438024ENST00000282516+45472227_226726202805.0RepeatNote=HEAT 4
HgeneNIPBLchr5:37061120chr5:37438024ENST00000282516+45472313_235126202805.0RepeatNote=HEAT 5
HgeneNIPBLchr5:37061120chr5:37438024ENST00000448238+45461767_180526202698.0RepeatNote=HEAT 1
HgeneNIPBLchr5:37061120chr5:37438024ENST00000448238+45461843_188126202698.0RepeatNote=HEAT 2
HgeneNIPBLchr5:37061120chr5:37438024ENST00000448238+45461945_198426202698.0RepeatNote=HEAT 3
HgeneNIPBLchr5:37061120chr5:37438024ENST00000448238+45462227_226726202698.0RepeatNote=HEAT 4
HgeneNIPBLchr5:37061120chr5:37438024ENST00000448238+45462313_235126202698.0RepeatNote=HEAT 5
TgeneWDR70chr5:37061120chr5:37438024ENST00000265107418180_219164655.0RepeatNote=WD 1
TgeneWDR70chr5:37061120chr5:37438024ENST00000265107418227_268164655.0RepeatNote=WD 2
TgeneWDR70chr5:37061120chr5:37438024ENST00000265107418281_321164655.0RepeatNote=WD 3
TgeneWDR70chr5:37061120chr5:37438024ENST00000265107418330_369164655.0RepeatNote=WD 4
TgeneWDR70chr5:37061120chr5:37438024ENST00000265107418376_415164655.0RepeatNote=WD 5
TgeneWDR70chr5:37061120chr5:37438024ENST00000265107418421_466164655.0RepeatNote=WD 6
TgeneWDR70chr5:37061120chr5:37438024ENST00000265107418469_508164655.0RepeatNote=WD 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneWDR70chr5:37061120chr5:37438024ENST00000265107418148_164164655.0Compositional biasNote=Glu-rich
TgeneWDR70chr5:37061120chr5:37438024ENST0000026510741884_113164655.0Compositional biasNote=Ser-rich


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Fusion Gene Sequence for NIPBL-WDR70


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>59215_59215_1_NIPBL-WDR70_NIPBL_chr5_37061120_ENST00000282516_WDR70_chr5_37438024_ENST00000265107_length(transcript)=10694nt_BP=8359nt
TCCGGTCGGCATTTTGTTCTGAGAGGGAGAGACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTC
CGTCGGTACCGACTCACCCGACACCACCAAGCCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCC
CCCCCGGTAGCTCGGGCCCGTGGTCGGGTGTTTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGT
CTTCTCGGCTGGTCTCCCCCCGGCTCTACATGTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGAT
TATAGTCTCTCGCCACAGCGGCCTCGGCCTCCCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTG
GCACCTGAACTAAGTACTTTTATAGGCAACACCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGC
GGGGATTGCTAGTCTCACAGACCTCCTGAACCAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGC
ACGAATAGCAGAAGAGGTGAACTGCCTTTTGGCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAAC
AGATCACATAGAGTTGAAAGATAACCTTGGCAGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCC
TAATGTTTTCAGGGAGAAAAGCATGCAGAACAGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCA
CAGTAGTCCTGCATCTTCCAATTATCAACAAACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAA
CAGATTTATGCCACAGCAAAATAGCCCAGTGCCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAG
TTACACAACACATCCACAGATGCAACAAGCATCGGTATCAAGTCCCATTGTTGCAGGTGGTTTGAGAAACATACATGATAATAAAGTTTC
TGGTCCGTTGTCTGGCAATTCAGCTAATCATCATGCTGATAATCCTAGACATGGTTCAAGTGAGGACTACCTACACATGGTGCACAGGCT
AAGTAGTGACGATGGAGATTCTTCAACAATGAGGAATGCTGCATCTTTTCCCTTGAGATCTCCACAGCCAGTATGCTCCCCTGCTGGAAG
TGAAGGAACTCCTAAAGGCTCAAGACCACCTTTAATCCTACAATCTCAGTCTCTACCTTGTTCATCACCTCGAGATGTTCCACCAGATAT
CTTGCTAGATTCTCCAGAAAGAAAACAAAAGAAGCAGAAGAAAATGAAATTAGGCAAGGATGAAAAAGAGCAGAGTGAGAAAGCGGCAAT
GTATGATATAATTAGTTCTCCATCCAAGGACTCTACTAAACTTACATTAAGACTTTCTCGTGTAAGGTCTTCAGACATGGACCAGCAAGA
GGATATGATTTCTGGTGTGGAAAATAGCAATGTTTCAGAAAATGATATTCCTTTTAATGTGCAGTACCCAGGACAGACTTCAAAAACACC
CATTACTCCACAAGATATAAACCGCCCACTAAATGCTGCTCAATGTTTGTCGCAGCAAGAACAAACAGCATTCCTTCCAGCAAATCAAGT
GCCTGTTTTACAACAGAACACTTCAGTTGCTGCAAAACAACCCCAGACTTCTGTGGTACAGAATCAACAACAGATATCACAACAGGGACC
TATATATGATGAAGTGGAATTGGATGCATTGGCTGAAATTGAGCGAATAGAGAGAGAATCAGCTATTGAAAGGGAGCGCTTCTCAAAAGA
AGTTCAAGATAAAGATAAGCCTTTGAAAAAAAGAAAACAAGATTCTTACCCACAGGAGGCTGGGGGTGCTACAGGAGGTAATAGACCAGC
TTCTCAGGAGACGGGTTCTACGGGAAATGGGTCAAGGCCAGCATTAATGGTTAGCATTGATCTTCATCAGGCAGGAAGAGTGGACTCTCA
GGCTTCTATAACTCAGGATTCAGACTCCATAAAAAAGCCTGAAGAAATCAAACAATGTAATGATGCACCTGTTTCTGTTCTTCAGGAAGA
TATTGTTGGAAGTCTTAAATCTACACCAGAAAACCATCCTGAGACACCTAAAAAAAAGTCTGATCCTGAGCTTTCAAAGAGTGAAATGAA
ACAAAGTGAAAGTAGATTAGCAGAATCTAAACCAAATGAAAACCGATTGGTGGAGACAAAATCAAGTGAAAATAAGTTAGAAACTAAAGT
TGAGACCCAAACAGAAGAACTTAAACAGAATGAGAGCAGAACAACTGAATGCAAACAAAACGAGAGCACCATAGTTGAGCCTAAACAAAA
TGAAAATAGACTGTCTGACACAAAACCAAATGACAACAAACAAAATAATGGCAGATCAGAAACAACAAAATCAAGGCCTGAAACCCCAAA
GCAAAAGGGTGAAAGCCGGCCTGAGACTCCAAAACAAAAGAGTGATGGGCATCCTGAAACCCCAAAACAGAAGGGTGATGGAAGGCCTGA
AACTCCAAAGCAAAAAGGTGAGAGCCGCCCTGAAACTCCAAAGCAAAAAAATGAAGGGCGACCTGAAACACCAAAACACAGGCATGACAA
TAGGAGGGATTCTGGAAAGCCATCTACAGAGAAAAAACCTGAAGTGTCTAAACATAAACAAGATACTAAATCTGACTCACCTCGGTTAAA
ATCAGAACGAGCTGAAGCCTTAAAGCAGAGACCTGATGGGCGATCTGTTTCTGAGTCACTAAGACGTGACCATGATAATAAACAAAAATC
AGATGACAGGGGTGAATCAGAGCGACATCGAGGGGATCAGTCTAGGGTTCGAAGACCAGAAACATTGAGATCCTCTAGTAGAAATGAACA
TGGCATTAAATCTGATAGTTCAAAAACTGATAAACTAGAACGAAAACACAGGCATGAATCAGGGGACTCAAGGGAAAGACCATCTTCTGG
GGAACAAAAATCAAGACCTGACAGTCCTCGTGTTAAACAAGGAGATTCTAATAAATCAAGATCTGATAAACTTGGTTTTAAATCACCAAC
TAGTAAAGATGACAAAAGGACAGAGGGTAACAAGAGTAAAGTAGACACTAATAAAGCACACCCTGACAATAAGGCAGAATTTCCAAGTTA
TTTGTTGGGGGGCAGGTCTGGTGCGTTGAAAAATTTTGTCATTCCGAAAATCAAGAGGGATAAAGATGGCAATGTTACTCAGGAGACAAA
GAAAATGGAAATGAAAGGAGAGCCGAAAGACAAAGTAGAAAAAATAGGATTAGTTGAAGATCTAAATAAAGGAGCTAAGCCTGTAGTTGT
GCTACAAAAACTGTCTTTGGATGATGTTCAGAAACTTATTAAAGATAGAGAGGACAAATCAAGAAGTTCCCTTAAACCTATCAAGAATAA
ACCATCAAAGTCAAATAAAGGTAGTATAGATCAATCAGTGTTAAAAGAATTACCCCCTGAACTCCTGGCAGAAATTGAGTCCACCATGCC
ACTTTGTGAACGTGTGAAAATGAACAAACGCAAGCGTAGCACAGTTAATGAAAAGCCAAAATATGCTGAAATCAGTTCAGATGAAGATAA
TGATAGTGATGAAGCTTTTGAATCCTCTAGGAAACGACATAAAAAAGATGATGATAAAGCTTGGGAATATGAAGAGCGTGACAGAAGAAG
CTCTGGGGATCATAGGAGAAGTGGCCACTCTCATGAAGGAAGAAGGAGTTCAGGTGGTGGTCGTTATCGAAACCGAAGTCCGTCAGATTC
TGACATGGAAGATTATTCTCCTCCTCCCAGCCTTAGTGAGGTTGCTAGGAAAATGAAGAAAAAAGAAAAACAGAAGAAAAGGAAAGCATA
TGAACCAAAACTAACACCTGAAGAAATGATGGACTCTTCAACTTTTAAGAGATTCACAGCCTCAATAGAGAATATTTTGGATAATTTGGA
AGATATGGATTTTACTGCGTTTGGTGATGATGATGAAATTCCTCAGGAACTGCTCTTAGGAAAACATCAGCTTAATGAACTTGGCAGTGA
ATCTGCTAAAATAAAAGCAATGGGTATAATGGATAAGCTTTCAACTGACAAAACTGTGAAAGTCTTAAATATCTTGGAGAAGAATATTCA
GGATGGGTCAAAGCTTTCCACTTTGTTAAATCATAATAACGATACTGAAGAAGAAGAAAGGTTATGGAGAGACCTTATTATGGAGAGAGT
TACAAAATCAGCGGATGCTTGTCTTACAACTATCAACATTATGACATCCCCTAACATGCCAAAAGCTGTGTACATTGAGGATGTAATTGA
AAGAGTTATACAGTACACTAAATTTCATTTGCAGAATACACTTTATCCTCAGTATGATCCTGTTTACAGATTAGATCCTCATGGAGGAGG
CTTATTAAGTTCAAAAGCAAAACGGGCTAAATGTTCTACCCATAAGCAGAGAGTAATAGTAATGCTTTATAACAAAGTTTGTGACATTGT
TAGCAGCTTATCAGAATTGCTAGAGATACAACTTCTTACAGACACAACAATTCTTCAGGTTTCATCTATGGGAATAACACCATTTTTTGT
GGAAAATGTCAGTGAACTACAGTTGTGTGCCATTAAGTTAGTCACTGCAGTATTCTCAAGATATGAAAAACATAGGCAGTTAATTTTGGA
AGAAATTTTTACTTCACTTGCAAGATTACCAACCAGCAAGAGGAGTTTAAGGAACTTCAGGTTAAACAGTAGTGATATGGATGGAGAACC
TATGTATATTCAGATGGTTACAGCACTGGTTTTACAACTTATTCAGTGTGTGGTACACTTACCATCATCAGAGAAGGACTCTAATGCAGA
AGAAGATTCAAATAAAAAAATTGACCAGGATGTTGTCATTACTAACTCTTATGAAACAGCTATGCGAACAGCCCAAAACTTCCTCTCCAT
CTTCCTTAAAAAATGTGGTAGTAAGCAAGGTGAAGAAGATTACAGACCACTGTTTGAAAATTTTGTTCAAGACCTTCTTTCAACAGTCAA
TAAGCCTGAATGGCCAGCTGCTGAACTACTCCTTAGTTTGTTAGGGAGACTGTTGGTTCATCAGTTCAGTAACAAGTCAACAGAGATGGC
TTTAAGAGTGGCATCTCTTGATTACCTTGGAACTGTTGCTGCACGGCTAAGAAAAGATGCTGTTACAAGCAAAATGGATCAAGGATCTAT
AGAACGCATTTTAAAACAGGTTTCAGGAGGGGAAGATGAAATCCAACAATTACAAAAAGCATTGCTTGATTACTTGGATGAAAACACTGA
GACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTTCGAGACACAACTCTGGAAACAGAAAAAGCAATGAAATC
ACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAGACAACTGGCCAAATTATGCATCGAGCTGAAAACCGAAA
AAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTAAAGATGAACTCTGATACTGTGGACTATGATGATGCTTG
CTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGATATTTATTTGACACAGATCCTACGAGTTCTTGGTGAAAA
TGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCTGTAGACCCCAGTATTCTAGCAAGGCTTGATATGCAACG
AGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCAGTAGAATTACTAGGTCGATTTGTCCTTTGTCGACCTCA
GCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGTATCAGTGTCAGGAAAAGAGTAATAAAGATTCTCAGAGA
CATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAAATGATTCGCAGAGTCAATGATGAAGAGGGCATTAAGAA
ATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAATGACAAAGAAGCAATGACAAGGAAAATTTTAAACATTAC
CGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTGCTTCAAAACTTGTTGAAGTCCGAAGAGGATTCCTCATA
TAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCACATTCTTAAATATGAGGAATCTCTAGCTGACTCTGACAA
TAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTATTCAGCAAAATAAGACCCCAGCTCATGGTTAAACATGC
AATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTCATGGTTATCTGCAATGTTGCAAAAATCCTAGAGCTAGT
TGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAAGATCTAATGAAGCTCATCATCAAATATGGCATGACTGT
AGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAAAATTTTAAATTTGTGTGGGCTTGTTTCAATAGATACTA
TGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACTTCACTTCTAACAAACAAACCAGCACTTCTTAGATCCCT
TTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTTAAAGGCAACAGCAAGGTTAACATAAAAGATAAAGTACT
TGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAAGCTATCATTGGTCTAGGATTTGCCTTTATTCAGCATCC
AAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCTGATAAGAACTCCTCAGTCAATTTAAAAATACAAGTGTT
AAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCAGATAGAGACTGGAAGAAAGTTGCAAAACAGGAAGACTT
AAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTTTATCTCAAACAGGTGCTTGAGGCATTTTTTCACACCCA
GTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAAGGTCTTATTCATCCAGTTCAGTGTGTGCCATATTTAAT
TGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAACTTGTGGAAATAGACAAAAAATATGCTGGATTCATTCA
TATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATCAACACATGCCTAAAAGATCCTGTAAGGGGTTTCAGACA
AGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGAAACCGCCAACACAGACGAGCCTTTCTTATTTCTTTACT
CAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATAGCAGACAATCTAGCCTGTTTTCCATACCAGACACAGGA
AGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGTAGTAACCTACTGCAGTCATTCAAGGAGTCTATGGTAAA
GGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAGTCACG
GAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAAAATTCAGCTCCTTTAAT
CGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGATTTTCTGATAGTAAAAT
TCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTTCATCCAAAACAAACACT
GGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTATCTAGATAATCCTGTTCA
CAAGATTCCTGACTCGCATGAGATAACGCTGAAGCATGGCACTAAAACAGTGTCTGCTTTGGGTCTGGATCCCTCAGGTGCCCGTTTGGT
GACAGGAGGATATGACTATGATGTTAAGTTTTGGGATTTTGCTGGAATGGATGCTTCTTTTAAGGCATTTCGATCCCTTCAGCCCTGTGA
GTGCCATCAGATCAAGTCATTACAGTATAGTAACACAGGAGACATGATTCTTGTTGTATCTGGAAGCTCTCAGGCCAAGGTGATTGACAG
AGATGGTTTTGAAGTAATGGAATGTATAAAAGGAGACCAGTATATTGTGGACATGGCCAACACCAAGGGTCATACAGCAATGCTTCATAC
TGGCTCATGGCATCCCAAAATAAAGGGAGAATTTATGACTTGCTCAAATGATGCGACTGTGAGGACGTGGGAAGTTGAAAATCCAAAGAA
GCAAAAAAGTGTGTTTAAACCACGGACGATGCAAGGCAAAAAAGTCATTCCCACTACGTGCACATATAGTAGAGATGGAAACCTCATAGC
AGCTGCCTGCCAGAATGGAAGCATACAGATCTGGGACCGAAATTTGACTGTTCATCCTAAGTTCCACTATAAACAGGCTCATGACTCGGG
CACAGACACTTCTTGCGTGACTTTTTCCTATGATGGTAATGTCCTTGCCTCTCGTGGAGGTGACGATTCATTAAAATTATGGGACATCCG
ACAATTTAATAAACCACTTTTTTCAGCCTCGGGTCTTCCCACCATGTTCCCAATGACTGACTGCTGTTTCAGTCCAGATGATAAGCTCAT
AGTCACTGGTACATCTATTCAAAGAGGATGTGGCAGCGGCAAACTTGTTTTCTTTGAGCGTAGGACTTTCCAAAGGGTGTATGAAATAGA
CATCACAGATGCGAGTGTTGTTCGCTGCCTGTGGCATCCAAAGCTGAACCAGATCATGGTTGGAACTGGAAATGGATTGGCTAAAGTCTA
TTACGACCCCAACAAGAGTCAGAGGGGAGCAAAATTATGTGTGGTTAAAACCCAGCGGAAGGCAAAACAAGCTGAGACTCTAACTCAGGA
CTACATCATCACCCCTCATGCCTTGCCTATGTTCCGTGAGCCCCGCCAACGGAGTACAAGGAAACAGCTGGAGAAGGACAGACTGGATCC
CCTGAAGTCGCATAAACCTGAACCTCCTGTAGCAGGCCCAGGTCGTGGTGGCCGAGTTGGAACCCACGGGGGCACTCTCTCTTCCTATAT
TGTGAAGAACATTGCTTTGGACAAGACCGATGACAGTAATCCTCGGGAAGCCATTTTGCGTCATGCCAAAGCAGCAGAAGACAGCCCATA
TTGGGTTTCTCCAGCATATTCCAAGACTCAGCCCAAAACCATGTTTGCCCAAGTTGAATCTGATGATGAGGAAGCAAAGAATGAGCCAGA
ATGGAAAAAACGTAAAATTTGAAGAATCTCATTTGAGAGCTGTTTGCATGAGTGGGAGGGGTATGGGACAGGTTTGGGTTTTTTTTTTAT
GCTCATGAAATTAAAAATTCATTTTTATGAACAGGTTTTGTCCTTTGCATTATTGAACTGGTCAAAAGTTTGGTGGCTAGGCTTCACTAA
AATTGTGCTTAAATTTTCTTACCTGCAACTATTAAACTGATTACAGATAAACAAGAAACAGATTCTTAGTCTATTACCAAGTACTTTAGG
TATTTGGAAACTTTATTCAACAATTATTGGTCTTGTCCAGATTCTCATAACCTTAGAGAGGAAAATGTACATTAAGATGTGCATCTGTCT
CTAGCAATTCTAGGAACATAATATAGAAATAGAGATCAAAAAGTTTAATGTTTCTGTATAATTTCACAACAGTTGTTTACATGACTGTAA
TTAATTAGGCTGAGTTCAAACCAAATACATTGCCATACTGGGAAAGAGCATTATCTCATTATCCTTCAATAGCAGAATACAGTGGTTAAG
AGTTAGGAGTGGGCTTTGAAGTCAGACTCATGTGGATTCAAGTCCTGGCTTTGCTCTTTACTTCTGGGTCATCTTAAGAGAGTTATTTAA
CTTTTCTTTTCTAGCCTCAGATGATGAAATAGTACGTACTTTGCAGGTTCGTCAGAAGAATTAAATGGGACATGCCTCACAGAGCATTTA
GTACAGTACCTGGAACACAGTAAATGTATACCAAATATTTGCTATTTTAAAATAGGGCTAATATTTACTTTGCTTGGTTTTTATCAGTAT

>59215_59215_1_NIPBL-WDR70_NIPBL_chr5_37061120_ENST00000282516_WDR70_chr5_37438024_ENST00000265107_length(amino acids)=3110AA_BP=0
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASF
PLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTL
RLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQT
SVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM
VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRL
VETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG
HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSV
SESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS
NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIG
LVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVN
EKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVAR
KMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTD
KTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERVIQYTKFHLQNTLYP
QYDPVYRLDPHGGGLLSSKAKRAKCSTHKQRVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA
VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQCVVHLPSSEKDSNAEEDSNKKIDQDVVITNS
YETAMRTAQNFLSIFLKKCGSKQGEEDYRPLFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVHQFSNKSTEMALRVASLDYLGTVAARL
RKDAVTSKMDQGSIERILKQVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQKDEESSEGTHHAKEI
ETTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVV
AVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDICIEQPTFPKITEMCV
KMIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVE
HILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVVPLMEHPSETFLATIE
EDLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLED
FKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLKNLQTYLQEEDTRMQQ
ADRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQ
QLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLNLFDDTAKTDVTMLLY
IADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDIN
SVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEV
KRSIVKQYLDNPVHKIPDSHEITLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDASFKAFRSLQPCECHQIKSLQYSNTGDMI
LVVSGSSQAKVIDRDGFEVMECIKGDQYIVDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRTWEVENPKKQKSVFKPRTMQGKKVI
PTTCTYSRDGNLIAAACQNGSIQIWDRNLTVHPKFHYKQAHDSGTDTSCVTFSYDGNVLASRGGDDSLKLWDIRQFNKPLFSASGLPTMF
PMTDCCFSPDDKLIVTGTSIQRGCGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVYYDPNKSQRGAKLCVVK
TQRKAKQAETLTQDYIITPHALPMFREPRQRSTRKQLEKDRLDPLKSHKPEPPVAGPGRGGRVGTHGGTLSSYIVKNIALDKTDDSNPRE

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>59215_59215_2_NIPBL-WDR70_NIPBL_chr5_37061120_ENST00000282516_WDR70_chr5_37438024_ENST00000504564_length(transcript)=9310nt_BP=8359nt
TCCGGTCGGCATTTTGTTCTGAGAGGGAGAGACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTC
CGTCGGTACCGACTCACCCGACACCACCAAGCCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCC
CCCCCGGTAGCTCGGGCCCGTGGTCGGGTGTTTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGT
CTTCTCGGCTGGTCTCCCCCCGGCTCTACATGTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGAT
TATAGTCTCTCGCCACAGCGGCCTCGGCCTCCCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTG
GCACCTGAACTAAGTACTTTTATAGGCAACACCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGC
GGGGATTGCTAGTCTCACAGACCTCCTGAACCAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGC
ACGAATAGCAGAAGAGGTGAACTGCCTTTTGGCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAAC
AGATCACATAGAGTTGAAAGATAACCTTGGCAGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCC
TAATGTTTTCAGGGAGAAAAGCATGCAGAACAGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCA
CAGTAGTCCTGCATCTTCCAATTATCAACAAACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAA
CAGATTTATGCCACAGCAAAATAGCCCAGTGCCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAG
TTACACAACACATCCACAGATGCAACAAGCATCGGTATCAAGTCCCATTGTTGCAGGTGGTTTGAGAAACATACATGATAATAAAGTTTC
TGGTCCGTTGTCTGGCAATTCAGCTAATCATCATGCTGATAATCCTAGACATGGTTCAAGTGAGGACTACCTACACATGGTGCACAGGCT
AAGTAGTGACGATGGAGATTCTTCAACAATGAGGAATGCTGCATCTTTTCCCTTGAGATCTCCACAGCCAGTATGCTCCCCTGCTGGAAG
TGAAGGAACTCCTAAAGGCTCAAGACCACCTTTAATCCTACAATCTCAGTCTCTACCTTGTTCATCACCTCGAGATGTTCCACCAGATAT
CTTGCTAGATTCTCCAGAAAGAAAACAAAAGAAGCAGAAGAAAATGAAATTAGGCAAGGATGAAAAAGAGCAGAGTGAGAAAGCGGCAAT
GTATGATATAATTAGTTCTCCATCCAAGGACTCTACTAAACTTACATTAAGACTTTCTCGTGTAAGGTCTTCAGACATGGACCAGCAAGA
GGATATGATTTCTGGTGTGGAAAATAGCAATGTTTCAGAAAATGATATTCCTTTTAATGTGCAGTACCCAGGACAGACTTCAAAAACACC
CATTACTCCACAAGATATAAACCGCCCACTAAATGCTGCTCAATGTTTGTCGCAGCAAGAACAAACAGCATTCCTTCCAGCAAATCAAGT
GCCTGTTTTACAACAGAACACTTCAGTTGCTGCAAAACAACCCCAGACTTCTGTGGTACAGAATCAACAACAGATATCACAACAGGGACC
TATATATGATGAAGTGGAATTGGATGCATTGGCTGAAATTGAGCGAATAGAGAGAGAATCAGCTATTGAAAGGGAGCGCTTCTCAAAAGA
AGTTCAAGATAAAGATAAGCCTTTGAAAAAAAGAAAACAAGATTCTTACCCACAGGAGGCTGGGGGTGCTACAGGAGGTAATAGACCAGC
TTCTCAGGAGACGGGTTCTACGGGAAATGGGTCAAGGCCAGCATTAATGGTTAGCATTGATCTTCATCAGGCAGGAAGAGTGGACTCTCA
GGCTTCTATAACTCAGGATTCAGACTCCATAAAAAAGCCTGAAGAAATCAAACAATGTAATGATGCACCTGTTTCTGTTCTTCAGGAAGA
TATTGTTGGAAGTCTTAAATCTACACCAGAAAACCATCCTGAGACACCTAAAAAAAAGTCTGATCCTGAGCTTTCAAAGAGTGAAATGAA
ACAAAGTGAAAGTAGATTAGCAGAATCTAAACCAAATGAAAACCGATTGGTGGAGACAAAATCAAGTGAAAATAAGTTAGAAACTAAAGT
TGAGACCCAAACAGAAGAACTTAAACAGAATGAGAGCAGAACAACTGAATGCAAACAAAACGAGAGCACCATAGTTGAGCCTAAACAAAA
TGAAAATAGACTGTCTGACACAAAACCAAATGACAACAAACAAAATAATGGCAGATCAGAAACAACAAAATCAAGGCCTGAAACCCCAAA
GCAAAAGGGTGAAAGCCGGCCTGAGACTCCAAAACAAAAGAGTGATGGGCATCCTGAAACCCCAAAACAGAAGGGTGATGGAAGGCCTGA
AACTCCAAAGCAAAAAGGTGAGAGCCGCCCTGAAACTCCAAAGCAAAAAAATGAAGGGCGACCTGAAACACCAAAACACAGGCATGACAA
TAGGAGGGATTCTGGAAAGCCATCTACAGAGAAAAAACCTGAAGTGTCTAAACATAAACAAGATACTAAATCTGACTCACCTCGGTTAAA
ATCAGAACGAGCTGAAGCCTTAAAGCAGAGACCTGATGGGCGATCTGTTTCTGAGTCACTAAGACGTGACCATGATAATAAACAAAAATC
AGATGACAGGGGTGAATCAGAGCGACATCGAGGGGATCAGTCTAGGGTTCGAAGACCAGAAACATTGAGATCCTCTAGTAGAAATGAACA
TGGCATTAAATCTGATAGTTCAAAAACTGATAAACTAGAACGAAAACACAGGCATGAATCAGGGGACTCAAGGGAAAGACCATCTTCTGG
GGAACAAAAATCAAGACCTGACAGTCCTCGTGTTAAACAAGGAGATTCTAATAAATCAAGATCTGATAAACTTGGTTTTAAATCACCAAC
TAGTAAAGATGACAAAAGGACAGAGGGTAACAAGAGTAAAGTAGACACTAATAAAGCACACCCTGACAATAAGGCAGAATTTCCAAGTTA
TTTGTTGGGGGGCAGGTCTGGTGCGTTGAAAAATTTTGTCATTCCGAAAATCAAGAGGGATAAAGATGGCAATGTTACTCAGGAGACAAA
GAAAATGGAAATGAAAGGAGAGCCGAAAGACAAAGTAGAAAAAATAGGATTAGTTGAAGATCTAAATAAAGGAGCTAAGCCTGTAGTTGT
GCTACAAAAACTGTCTTTGGATGATGTTCAGAAACTTATTAAAGATAGAGAGGACAAATCAAGAAGTTCCCTTAAACCTATCAAGAATAA
ACCATCAAAGTCAAATAAAGGTAGTATAGATCAATCAGTGTTAAAAGAATTACCCCCTGAACTCCTGGCAGAAATTGAGTCCACCATGCC
ACTTTGTGAACGTGTGAAAATGAACAAACGCAAGCGTAGCACAGTTAATGAAAAGCCAAAATATGCTGAAATCAGTTCAGATGAAGATAA
TGATAGTGATGAAGCTTTTGAATCCTCTAGGAAACGACATAAAAAAGATGATGATAAAGCTTGGGAATATGAAGAGCGTGACAGAAGAAG
CTCTGGGGATCATAGGAGAAGTGGCCACTCTCATGAAGGAAGAAGGAGTTCAGGTGGTGGTCGTTATCGAAACCGAAGTCCGTCAGATTC
TGACATGGAAGATTATTCTCCTCCTCCCAGCCTTAGTGAGGTTGCTAGGAAAATGAAGAAAAAAGAAAAACAGAAGAAAAGGAAAGCATA
TGAACCAAAACTAACACCTGAAGAAATGATGGACTCTTCAACTTTTAAGAGATTCACAGCCTCAATAGAGAATATTTTGGATAATTTGGA
AGATATGGATTTTACTGCGTTTGGTGATGATGATGAAATTCCTCAGGAACTGCTCTTAGGAAAACATCAGCTTAATGAACTTGGCAGTGA
ATCTGCTAAAATAAAAGCAATGGGTATAATGGATAAGCTTTCAACTGACAAAACTGTGAAAGTCTTAAATATCTTGGAGAAGAATATTCA
GGATGGGTCAAAGCTTTCCACTTTGTTAAATCATAATAACGATACTGAAGAAGAAGAAAGGTTATGGAGAGACCTTATTATGGAGAGAGT
TACAAAATCAGCGGATGCTTGTCTTACAACTATCAACATTATGACATCCCCTAACATGCCAAAAGCTGTGTACATTGAGGATGTAATTGA
AAGAGTTATACAGTACACTAAATTTCATTTGCAGAATACACTTTATCCTCAGTATGATCCTGTTTACAGATTAGATCCTCATGGAGGAGG
CTTATTAAGTTCAAAAGCAAAACGGGCTAAATGTTCTACCCATAAGCAGAGAGTAATAGTAATGCTTTATAACAAAGTTTGTGACATTGT
TAGCAGCTTATCAGAATTGCTAGAGATACAACTTCTTACAGACACAACAATTCTTCAGGTTTCATCTATGGGAATAACACCATTTTTTGT
GGAAAATGTCAGTGAACTACAGTTGTGTGCCATTAAGTTAGTCACTGCAGTATTCTCAAGATATGAAAAACATAGGCAGTTAATTTTGGA
AGAAATTTTTACTTCACTTGCAAGATTACCAACCAGCAAGAGGAGTTTAAGGAACTTCAGGTTAAACAGTAGTGATATGGATGGAGAACC
TATGTATATTCAGATGGTTACAGCACTGGTTTTACAACTTATTCAGTGTGTGGTACACTTACCATCATCAGAGAAGGACTCTAATGCAGA
AGAAGATTCAAATAAAAAAATTGACCAGGATGTTGTCATTACTAACTCTTATGAAACAGCTATGCGAACAGCCCAAAACTTCCTCTCCAT
CTTCCTTAAAAAATGTGGTAGTAAGCAAGGTGAAGAAGATTACAGACCACTGTTTGAAAATTTTGTTCAAGACCTTCTTTCAACAGTCAA
TAAGCCTGAATGGCCAGCTGCTGAACTACTCCTTAGTTTGTTAGGGAGACTGTTGGTTCATCAGTTCAGTAACAAGTCAACAGAGATGGC
TTTAAGAGTGGCATCTCTTGATTACCTTGGAACTGTTGCTGCACGGCTAAGAAAAGATGCTGTTACAAGCAAAATGGATCAAGGATCTAT
AGAACGCATTTTAAAACAGGTTTCAGGAGGGGAAGATGAAATCCAACAATTACAAAAAGCATTGCTTGATTACTTGGATGAAAACACTGA
GACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTTCGAGACACAACTCTGGAAACAGAAAAAGCAATGAAATC
ACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAGACAACTGGCCAAATTATGCATCGAGCTGAAAACCGAAA
AAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTAAAGATGAACTCTGATACTGTGGACTATGATGATGCTTG
CTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGATATTTATTTGACACAGATCCTACGAGTTCTTGGTGAAAA
TGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCTGTAGACCCCAGTATTCTAGCAAGGCTTGATATGCAACG
AGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCAGTAGAATTACTAGGTCGATTTGTCCTTTGTCGACCTCA
GCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGTATCAGTGTCAGGAAAAGAGTAATAAAGATTCTCAGAGA
CATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAAATGATTCGCAGAGTCAATGATGAAGAGGGCATTAAGAA
ATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAATGACAAAGAAGCAATGACAAGGAAAATTTTAAACATTAC
CGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTGCTTCAAAACTTGTTGAAGTCCGAAGAGGATTCCTCATA
TAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCACATTCTTAAATATGAGGAATCTCTAGCTGACTCTGACAA
TAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTATTCAGCAAAATAAGACCCCAGCTCATGGTTAAACATGC
AATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTCATGGTTATCTGCAATGTTGCAAAAATCCTAGAGCTAGT
TGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAAGATCTAATGAAGCTCATCATCAAATATGGCATGACTGT
AGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAAAATTTTAAATTTGTGTGGGCTTGTTTCAATAGATACTA
TGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACTTCACTTCTAACAAACAAACCAGCACTTCTTAGATCCCT
TTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTTAAAGGCAACAGCAAGGTTAACATAAAAGATAAAGTACT
TGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAAGCTATCATTGGTCTAGGATTTGCCTTTATTCAGCATCC
AAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCTGATAAGAACTCCTCAGTCAATTTAAAAATACAAGTGTT
AAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCAGATAGAGACTGGAAGAAAGTTGCAAAACAGGAAGACTT
AAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTTTATCTCAAACAGGTGCTTGAGGCATTTTTTCACACCCA
GTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAAGGTCTTATTCATCCAGTTCAGTGTGTGCCATATTTAAT
TGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAACTTGTGGAAATAGACAAAAAATATGCTGGATTCATTCA
TATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATCAACACATGCCTAAAAGATCCTGTAAGGGGTTTCAGACA
AGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGAAACCGCCAACACAGACGAGCCTTTCTTATTTCTTTACT
CAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATAGCAGACAATCTAGCCTGTTTTCCATACCAGACACAGGA
AGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGTAGTAACCTACTGCAGTCATTCAAGGAGTCTATGGTAAA
GGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAGTCACG
GAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAAAATTCAGCTCCTTTAAT
CGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGATTTTCTGATAGTAAAAT
TCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTTCATCCAAAACAAACACT
GGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTATCTAGATAATCCTGTTCA
CAAGATTCCTGACTCGCATGAGATAACGCTGAAGCATGGCACTAAAACAGTGTCTGCTTTGGGTCTGGATCCCTCAGGTGCCCGTTTGGT
GACAGGAGGATATGACTATGATGTTAAGTTTTGGGATTTTGCTGGAATGGATGCTTCTTTTAAGGCATTTCGATCCCTTCAGCCCTGTGA
GTGCCATCAGATCAAGTCATTACAGTATAGTAACACAGGAGACATGATTCTTGTTGTATCTGGAAGCTCTCAGGCCAAGGTGATTGACAG
AGATGGTTTTGAAGTAATGGAATGTATAAAAGGAGACCAGTATATTGTGGACATGGCCAACACCAAGGGTCATACAGCAATGCTTCATAC
TGGCTCATGGCATCCCAAAATAAAGGGAGAATTTATGACTTGCTCAAATGATGCGACTGTGAGGACGTGGGAAGTTGAAAATCCAAAGAA
GCAAAAAAGTGTGTTTAAACCACGGACGATGCAAGGCAAAAAAGTCATTCCCACTACGTGCACATATAGTAGAGATGGAAACCTCATAGC
AGCTGCCTGCCAGAATGGAAGCATACAGATCTGGGACCGAAATTTGACTAGCAACAAGTTAAGACTGTCATATGGAACTGTCTGCATGCT
CTGGGCTCACACTGAAGTTTGTGTGATGTGAATCCACTGGACTCTATAACTTTTAAGGTTCATCCTAAGTTCCACTATAAACAGGCTCAT
GACTCGGGCACAGACACTTCTTGCGTGACTTTTTCCTATGATGGTAATGTCCTTGCCTCTCGTGGAGGTAGGTTAAAAGCTTTCTTTTTG
ATGTATTTCTCTATATAAAATAATCATCTTTAACAAATATGACAATAATATCCTAGTGCTTAGTAAAGCTTGCTTTGATTTTTGTTAATG

>59215_59215_2_NIPBL-WDR70_NIPBL_chr5_37061120_ENST00000282516_WDR70_chr5_37438024_ENST00000504564_length(amino acids)=2843AA_BP=0
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASF
PLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTL
RLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQT
SVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM
VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRL
VETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG
HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSV
SESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS
NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIG
LVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVN
EKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVAR
KMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTD
KTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERVIQYTKFHLQNTLYP
QYDPVYRLDPHGGGLLSSKAKRAKCSTHKQRVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA
VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQCVVHLPSSEKDSNAEEDSNKKIDQDVVITNS
YETAMRTAQNFLSIFLKKCGSKQGEEDYRPLFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVHQFSNKSTEMALRVASLDYLGTVAARL
RKDAVTSKMDQGSIERILKQVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQKDEESSEGTHHAKEI
ETTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVV
AVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDICIEQPTFPKITEMCV
KMIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVE
HILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVVPLMEHPSETFLATIE
EDLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLED
FKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLKNLQTYLQEEDTRMQQ
ADRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQ
QLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLNLFDDTAKTDVTMLLY
IADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDIN
SVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEV
KRSIVKQYLDNPVHKIPDSHEITLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDASFKAFRSLQPCECHQIKSLQYSNTGDMI
LVVSGSSQAKVIDRDGFEVMECIKGDQYIVDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRTWEVENPKKQKSVFKPRTMQGKKVI

--------------------------------------------------------------
>59215_59215_3_NIPBL-WDR70_NIPBL_chr5_37061120_ENST00000448238_WDR70_chr5_37438024_ENST00000265107_length(transcript)=10663nt_BP=8328nt
ACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTCCGTCGGTACCGACTCACCCGACACCACCAAG
CCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCCCCCCCGGTAGCTCGGGCCCGTGGTCGGGTGT
TTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGTCTTCTCGGCTGGTCTCCCCCCGGCTCTACAT
GTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGATTATAGTCTCTCGCCACAGCGGCCTCGGCCTC
CCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTGGCACCTGAACTAAGTACTTTTATAGGCAACA
CCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGCGGGGATTGCTAGTCTCACAGACCTCCTGAAC
CAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGCACGAATAGCAGAAGAGGTGAACTGCCTTTTG
GCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAACAGATCACATAGAGTTGAAAGATAACCTTGGC
AGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCCTAATGTTTTCAGGGAGAAAAGCATGCAGAAC
AGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCACAGTAGTCCTGCATCTTCCAATTATCAACAA
ACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAACAGATTTATGCCACAGCAAAATAGCCCAGTG
CCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAGTTACACAACACATCCACAGATGCAACAAGCA
TCGGTATCAAGTCCCATTGTTGCAGGTGGTTTGAGAAACATACATGATAATAAAGTTTCTGGTCCGTTGTCTGGCAATTCAGCTAATCAT
CATGCTGATAATCCTAGACATGGTTCAAGTGAGGACTACCTACACATGGTGCACAGGCTAAGTAGTGACGATGGAGATTCTTCAACAATG
AGGAATGCTGCATCTTTTCCCTTGAGATCTCCACAGCCAGTATGCTCCCCTGCTGGAAGTGAAGGAACTCCTAAAGGCTCAAGACCACCT
TTAATCCTACAATCTCAGTCTCTACCTTGTTCATCACCTCGAGATGTTCCACCAGATATCTTGCTAGATTCTCCAGAAAGAAAACAAAAG
AAGCAGAAGAAAATGAAATTAGGCAAGGATGAAAAAGAGCAGAGTGAGAAAGCGGCAATGTATGATATAATTAGTTCTCCATCCAAGGAC
TCTACTAAACTTACATTAAGACTTTCTCGTGTAAGGTCTTCAGACATGGACCAGCAAGAGGATATGATTTCTGGTGTGGAAAATAGCAAT
GTTTCAGAAAATGATATTCCTTTTAATGTGCAGTACCCAGGACAGACTTCAAAAACACCCATTACTCCACAAGATATAAACCGCCCACTA
AATGCTGCTCAATGTTTGTCGCAGCAAGAACAAACAGCATTCCTTCCAGCAAATCAAGTGCCTGTTTTACAACAGAACACTTCAGTTGCT
GCAAAACAACCCCAGACTTCTGTGGTACAGAATCAACAACAGATATCACAACAGGGACCTATATATGATGAAGTGGAATTGGATGCATTG
GCTGAAATTGAGCGAATAGAGAGAGAATCAGCTATTGAAAGGGAGCGCTTCTCAAAAGAAGTTCAAGATAAAGATAAGCCTTTGAAAAAA
AGAAAACAAGATTCTTACCCACAGGAGGCTGGGGGTGCTACAGGAGGTAATAGACCAGCTTCTCAGGAGACGGGTTCTACGGGAAATGGG
TCAAGGCCAGCATTAATGGTTAGCATTGATCTTCATCAGGCAGGAAGAGTGGACTCTCAGGCTTCTATAACTCAGGATTCAGACTCCATA
AAAAAGCCTGAAGAAATCAAACAATGTAATGATGCACCTGTTTCTGTTCTTCAGGAAGATATTGTTGGAAGTCTTAAATCTACACCAGAA
AACCATCCTGAGACACCTAAAAAAAAGTCTGATCCTGAGCTTTCAAAGAGTGAAATGAAACAAAGTGAAAGTAGATTAGCAGAATCTAAA
CCAAATGAAAACCGATTGGTGGAGACAAAATCAAGTGAAAATAAGTTAGAAACTAAAGTTGAGACCCAAACAGAAGAACTTAAACAGAAT
GAGAGCAGAACAACTGAATGCAAACAAAACGAGAGCACCATAGTTGAGCCTAAACAAAATGAAAATAGACTGTCTGACACAAAACCAAAT
GACAACAAACAAAATAATGGCAGATCAGAAACAACAAAATCAAGGCCTGAAACCCCAAAGCAAAAGGGTGAAAGCCGGCCTGAGACTCCA
AAACAAAAGAGTGATGGGCATCCTGAAACCCCAAAACAGAAGGGTGATGGAAGGCCTGAAACTCCAAAGCAAAAAGGTGAGAGCCGCCCT
GAAACTCCAAAGCAAAAAAATGAAGGGCGACCTGAAACACCAAAACACAGGCATGACAATAGGAGGGATTCTGGAAAGCCATCTACAGAG
AAAAAACCTGAAGTGTCTAAACATAAACAAGATACTAAATCTGACTCACCTCGGTTAAAATCAGAACGAGCTGAAGCCTTAAAGCAGAGA
CCTGATGGGCGATCTGTTTCTGAGTCACTAAGACGTGACCATGATAATAAACAAAAATCAGATGACAGGGGTGAATCAGAGCGACATCGA
GGGGATCAGTCTAGGGTTCGAAGACCAGAAACATTGAGATCCTCTAGTAGAAATGAACATGGCATTAAATCTGATAGTTCAAAAACTGAT
AAACTAGAACGAAAACACAGGCATGAATCAGGGGACTCAAGGGAAAGACCATCTTCTGGGGAACAAAAATCAAGACCTGACAGTCCTCGT
GTTAAACAAGGAGATTCTAATAAATCAAGATCTGATAAACTTGGTTTTAAATCACCAACTAGTAAAGATGACAAAAGGACAGAGGGTAAC
AAGAGTAAAGTAGACACTAATAAAGCACACCCTGACAATAAGGCAGAATTTCCAAGTTATTTGTTGGGGGGCAGGTCTGGTGCGTTGAAA
AATTTTGTCATTCCGAAAATCAAGAGGGATAAAGATGGCAATGTTACTCAGGAGACAAAGAAAATGGAAATGAAAGGAGAGCCGAAAGAC
AAAGTAGAAAAAATAGGATTAGTTGAAGATCTAAATAAAGGAGCTAAGCCTGTAGTTGTGCTACAAAAACTGTCTTTGGATGATGTTCAG
AAACTTATTAAAGATAGAGAGGACAAATCAAGAAGTTCCCTTAAACCTATCAAGAATAAACCATCAAAGTCAAATAAAGGTAGTATAGAT
CAATCAGTGTTAAAAGAATTACCCCCTGAACTCCTGGCAGAAATTGAGTCCACCATGCCACTTTGTGAACGTGTGAAAATGAACAAACGC
AAGCGTAGCACAGTTAATGAAAAGCCAAAATATGCTGAAATCAGTTCAGATGAAGATAATGATAGTGATGAAGCTTTTGAATCCTCTAGG
AAACGACATAAAAAAGATGATGATAAAGCTTGGGAATATGAAGAGCGTGACAGAAGAAGCTCTGGGGATCATAGGAGAAGTGGCCACTCT
CATGAAGGAAGAAGGAGTTCAGGTGGTGGTCGTTATCGAAACCGAAGTCCGTCAGATTCTGACATGGAAGATTATTCTCCTCCTCCCAGC
CTTAGTGAGGTTGCTAGGAAAATGAAGAAAAAAGAAAAACAGAAGAAAAGGAAAGCATATGAACCAAAACTAACACCTGAAGAAATGATG
GACTCTTCAACTTTTAAGAGATTCACAGCCTCAATAGAGAATATTTTGGATAATTTGGAAGATATGGATTTTACTGCGTTTGGTGATGAT
GATGAAATTCCTCAGGAACTGCTCTTAGGAAAACATCAGCTTAATGAACTTGGCAGTGAATCTGCTAAAATAAAAGCAATGGGTATAATG
GATAAGCTTTCAACTGACAAAACTGTGAAAGTCTTAAATATCTTGGAGAAGAATATTCAGGATGGGTCAAAGCTTTCCACTTTGTTAAAT
CATAATAACGATACTGAAGAAGAAGAAAGGTTATGGAGAGACCTTATTATGGAGAGAGTTACAAAATCAGCGGATGCTTGTCTTACAACT
ATCAACATTATGACATCCCCTAACATGCCAAAAGCTGTGTACATTGAGGATGTAATTGAAAGAGTTATACAGTACACTAAATTTCATTTG
CAGAATACACTTTATCCTCAGTATGATCCTGTTTACAGATTAGATCCTCATGGAGGAGGCTTATTAAGTTCAAAAGCAAAACGGGCTAAA
TGTTCTACCCATAAGCAGAGAGTAATAGTAATGCTTTATAACAAAGTTTGTGACATTGTTAGCAGCTTATCAGAATTGCTAGAGATACAA
CTTCTTACAGACACAACAATTCTTCAGGTTTCATCTATGGGAATAACACCATTTTTTGTGGAAAATGTCAGTGAACTACAGTTGTGTGCC
ATTAAGTTAGTCACTGCAGTATTCTCAAGATATGAAAAACATAGGCAGTTAATTTTGGAAGAAATTTTTACTTCACTTGCAAGATTACCA
ACCAGCAAGAGGAGTTTAAGGAACTTCAGGTTAAACAGTAGTGATATGGATGGAGAACCTATGTATATTCAGATGGTTACAGCACTGGTT
TTACAACTTATTCAGTGTGTGGTACACTTACCATCATCAGAGAAGGACTCTAATGCAGAAGAAGATTCAAATAAAAAAATTGACCAGGAT
GTTGTCATTACTAACTCTTATGAAACAGCTATGCGAACAGCCCAAAACTTCCTCTCCATCTTCCTTAAAAAATGTGGTAGTAAGCAAGGT
GAAGAAGATTACAGACCACTGTTTGAAAATTTTGTTCAAGACCTTCTTTCAACAGTCAATAAGCCTGAATGGCCAGCTGCTGAACTACTC
CTTAGTTTGTTAGGGAGACTGTTGGTTCATCAGTTCAGTAACAAGTCAACAGAGATGGCTTTAAGAGTGGCATCTCTTGATTACCTTGGA
ACTGTTGCTGCACGGCTAAGAAAAGATGCTGTTACAAGCAAAATGGATCAAGGATCTATAGAACGCATTTTAAAACAGGTTTCAGGAGGG
GAAGATGAAATCCAACAATTACAAAAAGCATTGCTTGATTACTTGGATGAAAACACTGAGACTGATCCTTCACTAGTGTTTTCTCGTAAA
TTCTATATAGCCCAGTGGTTTCGAGACACAACTCTGGAAACAGAAAAAGCAATGAAATCACAAAAAGATGAAGAATCATCTGAAGGAACA
CATCATGCAAAGGAAATTGAGACAACTGGCCAAATTATGCATCGAGCTGAAAACCGAAAAAAGTTTCTTAGAAGCATTATCAAAACCACA
CCTTCTCAGTTTAGCACATTAAAGATGAACTCTGATACTGTGGACTATGATGATGCTTGCTTGATTGTTCGATACTTGGCCTCCATGAGG
CCGTTTGCCCAGAGCTTTGATATTTATTTGACACAGATCCTACGAGTTCTTGGTGAAAATGCAATTGCTGTTCGAACAAAAGCCATGAAG
TGTTTGTCTGAGGTTGTTGCTGTAGACCCCAGTATTCTAGCAAGGCTTGATATGCAACGAGGTGTTCATGGACGATTGATGGATAATTCG
ACTAGTGTCCGAGAAGCAGCAGTAGAATTACTAGGTCGATTTGTCCTTTGTCGACCTCAGCTTGCTGAACAGTATTATGATATGCTGATT
GAAAGAATATTGGATACTGGTATCAGTGTCAGGAAAAGAGTAATAAAGATTCTCAGAGACATTTGTATTGAACAACCAACATTTCCAAAA
ATCACAGAAATGTGTGTAAAAATGATTCGCAGAGTCAATGATGAAGAGGGCATTAAGAAATTAGTAAATGAAACATTCCAGAAACTCTGG
TTTACTCCAACTCCACACAATGACAAAGAAGCAATGACAAGGAAAATTTTAAACATTACCGATGTGGTTGCAGCATGCAGAGATACTGGA
TATGACTGGTTTGAGCAACTGCTTCAAAACTTGTTGAAGTCCGAAGAGGATTCCTCATATAAACCTGTGAAGAAAGCTTGTACTCAACTT
GTTGATAACCTAGTTGAGCACATTCTTAAATATGAGGAATCTCTAGCTGACTCTGACAATAAAGGTGTGAATTCTGGAAGATTGGTAGCT
TGCATAACCACTTTGTTCTTATTCAGCAAAATAAGACCCCAGCTCATGGTTAAACATGCAATGACTATGCAACCATACCTTACCACTAAA
TGTAGTACGCAAAATGATTTCATGGTTATCTGCAATGTTGCAAAAATCCTAGAGCTAGTTGTACCACTGATGGAGCATCCAAGTGAAACT
TTTCTTGCCACTATTGAGGAAGATCTAATGAAGCTCATCATCAAATATGGCATGACTGTAGTGCAACATTGTGTGAGCTGTCTTGGAGCT
GTTGTAAATAAAGTGACACAAAATTTTAAATTTGTGTGGGCTTGTTTCAATAGATACTATGGTGCCATTTCAAAATTAAAAAGTCAACAC
CAAGAGGACCCAAATAACACTTCACTTCTAACAAACAAACCAGCACTTCTTAGATCCCTTTTCACCGTTGGAGCACTATGTCGGCATTTT
GATTTTGATCTGGAAGATTTTAAAGGCAACAGCAAGGTTAACATAAAAGATAAAGTACTTGAACTATTGATGTATTTTACAAAACACTCA
GATGAAGAAGTACAAACAAAAGCTATCATTGGTCTAGGATTTGCCTTTATTCAGCATCCAAGTCTAATGTTCGAGCAAGAAGTGAAGAAT
CTATATAATAATATTTTATCTGATAAGAACTCCTCAGTCAATTTAAAAATACAAGTGTTAAAAAACCTCCAGACCTACCTACAAGAAGAA
GATACACGTATGCAGCAGGCAGATAGAGACTGGAAGAAAGTTGCAAAACAGGAAGACTTAAAAGAAATGGGTGATGTTTCCTCAGGGATG
AGTAGTTCCATCATGCAGCTTTATCTCAAACAGGTGCTTGAGGCATTTTTTCACACCCAGTCAAGTGTACGCCACTTTGCCCTAAATGTC
ATTGCATTGACTCTAAATCAAGGTCTTATTCATCCAGTTCAGTGTGTGCCATATTTAATTGCTATGGGCACAGACCCAGAACCTGCTATG
CGGAACAAGGCTGATCAGCAACTTGTGGAAATAGACAAAAAATATGCTGGATTCATTCATATGAAAGCAGTGGCTGGTATGAAGATGTCT
TACCAGGTACAACAGGCAATCAACACATGCCTAAAAGATCCTGTAAGGGGTTTCAGACAAGACGAGTCCTCTAGCGCTTTGTGTTCACAC
CTTTACTCCATGATCCGTGGAAACCGCCAACACAGACGAGCCTTTCTTATTTCTTTACTCAACCTCTTTGATGACACAGCAAAAACAGAC
GTGACTATGCTCTTGTATATAGCAGACAATCTAGCCTGTTTTCCATACCAGACACAGGAAGAGCCGTTGTTTATAATGCATCATATAGAC
ATTACACTCTCAGTTTCTGGTAGTAACCTACTGCAGTCATTCAAGGAGTCTATGGTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCT
AGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAGTCACGGAAACGTGTAGATTCAGATTCAGATTCAGAT
TCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAAAATTCAGCTCCTTTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTA
TTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGATTTTCTGATAGTAAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAA
GTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTTCATCCAAAACAAACACTGGACTTCCTGCGGAGTGACATGGCTAATTCC
AAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTATCTAGATAATCCTGTTCACAAGATTCCTGACTCGCATGAGATAACGCTG
AAGCATGGCACTAAAACAGTGTCTGCTTTGGGTCTGGATCCCTCAGGTGCCCGTTTGGTGACAGGAGGATATGACTATGATGTTAAGTTT
TGGGATTTTGCTGGAATGGATGCTTCTTTTAAGGCATTTCGATCCCTTCAGCCCTGTGAGTGCCATCAGATCAAGTCATTACAGTATAGT
AACACAGGAGACATGATTCTTGTTGTATCTGGAAGCTCTCAGGCCAAGGTGATTGACAGAGATGGTTTTGAAGTAATGGAATGTATAAAA
GGAGACCAGTATATTGTGGACATGGCCAACACCAAGGGTCATACAGCAATGCTTCATACTGGCTCATGGCATCCCAAAATAAAGGGAGAA
TTTATGACTTGCTCAAATGATGCGACTGTGAGGACGTGGGAAGTTGAAAATCCAAAGAAGCAAAAAAGTGTGTTTAAACCACGGACGATG
CAAGGCAAAAAAGTCATTCCCACTACGTGCACATATAGTAGAGATGGAAACCTCATAGCAGCTGCCTGCCAGAATGGAAGCATACAGATC
TGGGACCGAAATTTGACTGTTCATCCTAAGTTCCACTATAAACAGGCTCATGACTCGGGCACAGACACTTCTTGCGTGACTTTTTCCTAT
GATGGTAATGTCCTTGCCTCTCGTGGAGGTGACGATTCATTAAAATTATGGGACATCCGACAATTTAATAAACCACTTTTTTCAGCCTCG
GGTCTTCCCACCATGTTCCCAATGACTGACTGCTGTTTCAGTCCAGATGATAAGCTCATAGTCACTGGTACATCTATTCAAAGAGGATGT
GGCAGCGGCAAACTTGTTTTCTTTGAGCGTAGGACTTTCCAAAGGGTGTATGAAATAGACATCACAGATGCGAGTGTTGTTCGCTGCCTG
TGGCATCCAAAGCTGAACCAGATCATGGTTGGAACTGGAAATGGATTGGCTAAAGTCTATTACGACCCCAACAAGAGTCAGAGGGGAGCA
AAATTATGTGTGGTTAAAACCCAGCGGAAGGCAAAACAAGCTGAGACTCTAACTCAGGACTACATCATCACCCCTCATGCCTTGCCTATG
TTCCGTGAGCCCCGCCAACGGAGTACAAGGAAACAGCTGGAGAAGGACAGACTGGATCCCCTGAAGTCGCATAAACCTGAACCTCCTGTA
GCAGGCCCAGGTCGTGGTGGCCGAGTTGGAACCCACGGGGGCACTCTCTCTTCCTATATTGTGAAGAACATTGCTTTGGACAAGACCGAT
GACAGTAATCCTCGGGAAGCCATTTTGCGTCATGCCAAAGCAGCAGAAGACAGCCCATATTGGGTTTCTCCAGCATATTCCAAGACTCAG
CCCAAAACCATGTTTGCCCAAGTTGAATCTGATGATGAGGAAGCAAAGAATGAGCCAGAATGGAAAAAACGTAAAATTTGAAGAATCTCA
TTTGAGAGCTGTTTGCATGAGTGGGAGGGGTATGGGACAGGTTTGGGTTTTTTTTTTATGCTCATGAAATTAAAAATTCATTTTTATGAA
CAGGTTTTGTCCTTTGCATTATTGAACTGGTCAAAAGTTTGGTGGCTAGGCTTCACTAAAATTGTGCTTAAATTTTCTTACCTGCAACTA
TTAAACTGATTACAGATAAACAAGAAACAGATTCTTAGTCTATTACCAAGTACTTTAGGTATTTGGAAACTTTATTCAACAATTATTGGT
CTTGTCCAGATTCTCATAACCTTAGAGAGGAAAATGTACATTAAGATGTGCATCTGTCTCTAGCAATTCTAGGAACATAATATAGAAATA
GAGATCAAAAAGTTTAATGTTTCTGTATAATTTCACAACAGTTGTTTACATGACTGTAATTAATTAGGCTGAGTTCAAACCAAATACATT
GCCATACTGGGAAAGAGCATTATCTCATTATCCTTCAATAGCAGAATACAGTGGTTAAGAGTTAGGAGTGGGCTTTGAAGTCAGACTCAT
GTGGATTCAAGTCCTGGCTTTGCTCTTTACTTCTGGGTCATCTTAAGAGAGTTATTTAACTTTTCTTTTCTAGCCTCAGATGATGAAATA
GTACGTACTTTGCAGGTTCGTCAGAAGAATTAAATGGGACATGCCTCACAGAGCATTTAGTACAGTACCTGGAACACAGTAAATGTATAC
CAAATATTTGCTATTTTAAAATAGGGCTAATATTTACTTTGCTTGGTTTTTATCAGTATTAAATTAGAAAGGTATAGAATTGCTTTGTAA

>59215_59215_3_NIPBL-WDR70_NIPBL_chr5_37061120_ENST00000448238_WDR70_chr5_37438024_ENST00000265107_length(amino acids)=3110AA_BP=0
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASF
PLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTL
RLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQT
SVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM
VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRL
VETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG
HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSV
SESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS
NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIG
LVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVN
EKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVAR
KMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTD
KTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERVIQYTKFHLQNTLYP
QYDPVYRLDPHGGGLLSSKAKRAKCSTHKQRVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA
VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQCVVHLPSSEKDSNAEEDSNKKIDQDVVITNS
YETAMRTAQNFLSIFLKKCGSKQGEEDYRPLFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVHQFSNKSTEMALRVASLDYLGTVAARL
RKDAVTSKMDQGSIERILKQVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQKDEESSEGTHHAKEI
ETTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVV
AVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDICIEQPTFPKITEMCV
KMIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVE
HILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVVPLMEHPSETFLATIE
EDLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLED
FKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLKNLQTYLQEEDTRMQQ
ADRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQ
QLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLNLFDDTAKTDVTMLLY
IADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDIN
SVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEV
KRSIVKQYLDNPVHKIPDSHEITLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDASFKAFRSLQPCECHQIKSLQYSNTGDMI
LVVSGSSQAKVIDRDGFEVMECIKGDQYIVDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRTWEVENPKKQKSVFKPRTMQGKKVI
PTTCTYSRDGNLIAAACQNGSIQIWDRNLTVHPKFHYKQAHDSGTDTSCVTFSYDGNVLASRGGDDSLKLWDIRQFNKPLFSASGLPTMF
PMTDCCFSPDDKLIVTGTSIQRGCGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVYYDPNKSQRGAKLCVVK
TQRKAKQAETLTQDYIITPHALPMFREPRQRSTRKQLEKDRLDPLKSHKPEPPVAGPGRGGRVGTHGGTLSSYIVKNIALDKTDDSNPRE

--------------------------------------------------------------
>59215_59215_4_NIPBL-WDR70_NIPBL_chr5_37061120_ENST00000448238_WDR70_chr5_37438024_ENST00000504564_length(transcript)=9279nt_BP=8328nt
ACGGAACGAGAGAGAGACACACACAGGGCTCCTTCCCCCCGCCCTCCCCCCCCTCCCTCCGTCGGTACCGACTCACCCGACACCACCAAG
CCGCAGGGAGGGACGCCCCCGCCGACAGGAGAATTGGTTCCCGGGCCCGCGGCGATGCCCCCCCGGTAGCTCGGGCCCGTGGTCGGGTGT
TTGTGAGTGTTTCTATGTGGGAGAAGGAGGAGGAGGAGGAAGAAGAAGCAACGATTTGTCTTCTCGGCTGGTCTCCCCCCGGCTCTACAT
GTTCCCCGCACTGAGGAGACGGAAGAGGAGCCGTAGCCACCCCCCCTCCCGGCCCGGATTATAGTCTCTCGCCACAGCGGCCTCGGCCTC
CCCTTGGATTCAGACGCCGATTCGCCCAGTGTTTGGGAAATGGGAAGTAATGACAGCTGGCACCTGAACTAAGTACTTTTATAGGCAACA
CCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGCGGGGATTGCTAGTCTCACAGACCTCCTGAAC
CAGCTGCCTCTTCCATCTCCTTTACCTGCTACAACTACAAAGAGCCTTCTCTTTAATGCACGAATAGCAGAAGAGGTGAACTGCCTTTTG
GCTTGTAGGGATGACAATTTGGTTTCACAGCTTGTCCATAGCCTCAACCAGGTATCAACAGATCACATAGAGTTGAAAGATAACCTTGGC
AGTGATGACCCAGAAGGTGACATACCAGTCTTGTTGCAGGCCGTCCTGGCAAGGAGTCCTAATGTTTTCAGGGAGAAAAGCATGCAGAAC
AGATATGTACAAAGTGGAATGATGATGTCTCAGTATAAACTTTCTCAGAATTCCATGCACAGTAGTCCTGCATCTTCCAATTATCAACAA
ACCACTATCTCACATAGCCCCTCCAGCCGGTTTGTGCCACCACAGACAAGCTCTGGGAACAGATTTATGCCACAGCAAAATAGCCCAGTG
CCTAGTCCATACGCCCCACAAAGCCCTGCAGGATACATGCCATATTCCCATCCTTCAAGTTACACAACACATCCACAGATGCAACAAGCA
TCGGTATCAAGTCCCATTGTTGCAGGTGGTTTGAGAAACATACATGATAATAAAGTTTCTGGTCCGTTGTCTGGCAATTCAGCTAATCAT
CATGCTGATAATCCTAGACATGGTTCAAGTGAGGACTACCTACACATGGTGCACAGGCTAAGTAGTGACGATGGAGATTCTTCAACAATG
AGGAATGCTGCATCTTTTCCCTTGAGATCTCCACAGCCAGTATGCTCCCCTGCTGGAAGTGAAGGAACTCCTAAAGGCTCAAGACCACCT
TTAATCCTACAATCTCAGTCTCTACCTTGTTCATCACCTCGAGATGTTCCACCAGATATCTTGCTAGATTCTCCAGAAAGAAAACAAAAG
AAGCAGAAGAAAATGAAATTAGGCAAGGATGAAAAAGAGCAGAGTGAGAAAGCGGCAATGTATGATATAATTAGTTCTCCATCCAAGGAC
TCTACTAAACTTACATTAAGACTTTCTCGTGTAAGGTCTTCAGACATGGACCAGCAAGAGGATATGATTTCTGGTGTGGAAAATAGCAAT
GTTTCAGAAAATGATATTCCTTTTAATGTGCAGTACCCAGGACAGACTTCAAAAACACCCATTACTCCACAAGATATAAACCGCCCACTA
AATGCTGCTCAATGTTTGTCGCAGCAAGAACAAACAGCATTCCTTCCAGCAAATCAAGTGCCTGTTTTACAACAGAACACTTCAGTTGCT
GCAAAACAACCCCAGACTTCTGTGGTACAGAATCAACAACAGATATCACAACAGGGACCTATATATGATGAAGTGGAATTGGATGCATTG
GCTGAAATTGAGCGAATAGAGAGAGAATCAGCTATTGAAAGGGAGCGCTTCTCAAAAGAAGTTCAAGATAAAGATAAGCCTTTGAAAAAA
AGAAAACAAGATTCTTACCCACAGGAGGCTGGGGGTGCTACAGGAGGTAATAGACCAGCTTCTCAGGAGACGGGTTCTACGGGAAATGGG
TCAAGGCCAGCATTAATGGTTAGCATTGATCTTCATCAGGCAGGAAGAGTGGACTCTCAGGCTTCTATAACTCAGGATTCAGACTCCATA
AAAAAGCCTGAAGAAATCAAACAATGTAATGATGCACCTGTTTCTGTTCTTCAGGAAGATATTGTTGGAAGTCTTAAATCTACACCAGAA
AACCATCCTGAGACACCTAAAAAAAAGTCTGATCCTGAGCTTTCAAAGAGTGAAATGAAACAAAGTGAAAGTAGATTAGCAGAATCTAAA
CCAAATGAAAACCGATTGGTGGAGACAAAATCAAGTGAAAATAAGTTAGAAACTAAAGTTGAGACCCAAACAGAAGAACTTAAACAGAAT
GAGAGCAGAACAACTGAATGCAAACAAAACGAGAGCACCATAGTTGAGCCTAAACAAAATGAAAATAGACTGTCTGACACAAAACCAAAT
GACAACAAACAAAATAATGGCAGATCAGAAACAACAAAATCAAGGCCTGAAACCCCAAAGCAAAAGGGTGAAAGCCGGCCTGAGACTCCA
AAACAAAAGAGTGATGGGCATCCTGAAACCCCAAAACAGAAGGGTGATGGAAGGCCTGAAACTCCAAAGCAAAAAGGTGAGAGCCGCCCT
GAAACTCCAAAGCAAAAAAATGAAGGGCGACCTGAAACACCAAAACACAGGCATGACAATAGGAGGGATTCTGGAAAGCCATCTACAGAG
AAAAAACCTGAAGTGTCTAAACATAAACAAGATACTAAATCTGACTCACCTCGGTTAAAATCAGAACGAGCTGAAGCCTTAAAGCAGAGA
CCTGATGGGCGATCTGTTTCTGAGTCACTAAGACGTGACCATGATAATAAACAAAAATCAGATGACAGGGGTGAATCAGAGCGACATCGA
GGGGATCAGTCTAGGGTTCGAAGACCAGAAACATTGAGATCCTCTAGTAGAAATGAACATGGCATTAAATCTGATAGTTCAAAAACTGAT
AAACTAGAACGAAAACACAGGCATGAATCAGGGGACTCAAGGGAAAGACCATCTTCTGGGGAACAAAAATCAAGACCTGACAGTCCTCGT
GTTAAACAAGGAGATTCTAATAAATCAAGATCTGATAAACTTGGTTTTAAATCACCAACTAGTAAAGATGACAAAAGGACAGAGGGTAAC
AAGAGTAAAGTAGACACTAATAAAGCACACCCTGACAATAAGGCAGAATTTCCAAGTTATTTGTTGGGGGGCAGGTCTGGTGCGTTGAAA
AATTTTGTCATTCCGAAAATCAAGAGGGATAAAGATGGCAATGTTACTCAGGAGACAAAGAAAATGGAAATGAAAGGAGAGCCGAAAGAC
AAAGTAGAAAAAATAGGATTAGTTGAAGATCTAAATAAAGGAGCTAAGCCTGTAGTTGTGCTACAAAAACTGTCTTTGGATGATGTTCAG
AAACTTATTAAAGATAGAGAGGACAAATCAAGAAGTTCCCTTAAACCTATCAAGAATAAACCATCAAAGTCAAATAAAGGTAGTATAGAT
CAATCAGTGTTAAAAGAATTACCCCCTGAACTCCTGGCAGAAATTGAGTCCACCATGCCACTTTGTGAACGTGTGAAAATGAACAAACGC
AAGCGTAGCACAGTTAATGAAAAGCCAAAATATGCTGAAATCAGTTCAGATGAAGATAATGATAGTGATGAAGCTTTTGAATCCTCTAGG
AAACGACATAAAAAAGATGATGATAAAGCTTGGGAATATGAAGAGCGTGACAGAAGAAGCTCTGGGGATCATAGGAGAAGTGGCCACTCT
CATGAAGGAAGAAGGAGTTCAGGTGGTGGTCGTTATCGAAACCGAAGTCCGTCAGATTCTGACATGGAAGATTATTCTCCTCCTCCCAGC
CTTAGTGAGGTTGCTAGGAAAATGAAGAAAAAAGAAAAACAGAAGAAAAGGAAAGCATATGAACCAAAACTAACACCTGAAGAAATGATG
GACTCTTCAACTTTTAAGAGATTCACAGCCTCAATAGAGAATATTTTGGATAATTTGGAAGATATGGATTTTACTGCGTTTGGTGATGAT
GATGAAATTCCTCAGGAACTGCTCTTAGGAAAACATCAGCTTAATGAACTTGGCAGTGAATCTGCTAAAATAAAAGCAATGGGTATAATG
GATAAGCTTTCAACTGACAAAACTGTGAAAGTCTTAAATATCTTGGAGAAGAATATTCAGGATGGGTCAAAGCTTTCCACTTTGTTAAAT
CATAATAACGATACTGAAGAAGAAGAAAGGTTATGGAGAGACCTTATTATGGAGAGAGTTACAAAATCAGCGGATGCTTGTCTTACAACT
ATCAACATTATGACATCCCCTAACATGCCAAAAGCTGTGTACATTGAGGATGTAATTGAAAGAGTTATACAGTACACTAAATTTCATTTG
CAGAATACACTTTATCCTCAGTATGATCCTGTTTACAGATTAGATCCTCATGGAGGAGGCTTATTAAGTTCAAAAGCAAAACGGGCTAAA
TGTTCTACCCATAAGCAGAGAGTAATAGTAATGCTTTATAACAAAGTTTGTGACATTGTTAGCAGCTTATCAGAATTGCTAGAGATACAA
CTTCTTACAGACACAACAATTCTTCAGGTTTCATCTATGGGAATAACACCATTTTTTGTGGAAAATGTCAGTGAACTACAGTTGTGTGCC
ATTAAGTTAGTCACTGCAGTATTCTCAAGATATGAAAAACATAGGCAGTTAATTTTGGAAGAAATTTTTACTTCACTTGCAAGATTACCA
ACCAGCAAGAGGAGTTTAAGGAACTTCAGGTTAAACAGTAGTGATATGGATGGAGAACCTATGTATATTCAGATGGTTACAGCACTGGTT
TTACAACTTATTCAGTGTGTGGTACACTTACCATCATCAGAGAAGGACTCTAATGCAGAAGAAGATTCAAATAAAAAAATTGACCAGGAT
GTTGTCATTACTAACTCTTATGAAACAGCTATGCGAACAGCCCAAAACTTCCTCTCCATCTTCCTTAAAAAATGTGGTAGTAAGCAAGGT
GAAGAAGATTACAGACCACTGTTTGAAAATTTTGTTCAAGACCTTCTTTCAACAGTCAATAAGCCTGAATGGCCAGCTGCTGAACTACTC
CTTAGTTTGTTAGGGAGACTGTTGGTTCATCAGTTCAGTAACAAGTCAACAGAGATGGCTTTAAGAGTGGCATCTCTTGATTACCTTGGA
ACTGTTGCTGCACGGCTAAGAAAAGATGCTGTTACAAGCAAAATGGATCAAGGATCTATAGAACGCATTTTAAAACAGGTTTCAGGAGGG
GAAGATGAAATCCAACAATTACAAAAAGCATTGCTTGATTACTTGGATGAAAACACTGAGACTGATCCTTCACTAGTGTTTTCTCGTAAA
TTCTATATAGCCCAGTGGTTTCGAGACACAACTCTGGAAACAGAAAAAGCAATGAAATCACAAAAAGATGAAGAATCATCTGAAGGAACA
CATCATGCAAAGGAAATTGAGACAACTGGCCAAATTATGCATCGAGCTGAAAACCGAAAAAAGTTTCTTAGAAGCATTATCAAAACCACA
CCTTCTCAGTTTAGCACATTAAAGATGAACTCTGATACTGTGGACTATGATGATGCTTGCTTGATTGTTCGATACTTGGCCTCCATGAGG
CCGTTTGCCCAGAGCTTTGATATTTATTTGACACAGATCCTACGAGTTCTTGGTGAAAATGCAATTGCTGTTCGAACAAAAGCCATGAAG
TGTTTGTCTGAGGTTGTTGCTGTAGACCCCAGTATTCTAGCAAGGCTTGATATGCAACGAGGTGTTCATGGACGATTGATGGATAATTCG
ACTAGTGTCCGAGAAGCAGCAGTAGAATTACTAGGTCGATTTGTCCTTTGTCGACCTCAGCTTGCTGAACAGTATTATGATATGCTGATT
GAAAGAATATTGGATACTGGTATCAGTGTCAGGAAAAGAGTAATAAAGATTCTCAGAGACATTTGTATTGAACAACCAACATTTCCAAAA
ATCACAGAAATGTGTGTAAAAATGATTCGCAGAGTCAATGATGAAGAGGGCATTAAGAAATTAGTAAATGAAACATTCCAGAAACTCTGG
TTTACTCCAACTCCACACAATGACAAAGAAGCAATGACAAGGAAAATTTTAAACATTACCGATGTGGTTGCAGCATGCAGAGATACTGGA
TATGACTGGTTTGAGCAACTGCTTCAAAACTTGTTGAAGTCCGAAGAGGATTCCTCATATAAACCTGTGAAGAAAGCTTGTACTCAACTT
GTTGATAACCTAGTTGAGCACATTCTTAAATATGAGGAATCTCTAGCTGACTCTGACAATAAAGGTGTGAATTCTGGAAGATTGGTAGCT
TGCATAACCACTTTGTTCTTATTCAGCAAAATAAGACCCCAGCTCATGGTTAAACATGCAATGACTATGCAACCATACCTTACCACTAAA
TGTAGTACGCAAAATGATTTCATGGTTATCTGCAATGTTGCAAAAATCCTAGAGCTAGTTGTACCACTGATGGAGCATCCAAGTGAAACT
TTTCTTGCCACTATTGAGGAAGATCTAATGAAGCTCATCATCAAATATGGCATGACTGTAGTGCAACATTGTGTGAGCTGTCTTGGAGCT
GTTGTAAATAAAGTGACACAAAATTTTAAATTTGTGTGGGCTTGTTTCAATAGATACTATGGTGCCATTTCAAAATTAAAAAGTCAACAC
CAAGAGGACCCAAATAACACTTCACTTCTAACAAACAAACCAGCACTTCTTAGATCCCTTTTCACCGTTGGAGCACTATGTCGGCATTTT
GATTTTGATCTGGAAGATTTTAAAGGCAACAGCAAGGTTAACATAAAAGATAAAGTACTTGAACTATTGATGTATTTTACAAAACACTCA
GATGAAGAAGTACAAACAAAAGCTATCATTGGTCTAGGATTTGCCTTTATTCAGCATCCAAGTCTAATGTTCGAGCAAGAAGTGAAGAAT
CTATATAATAATATTTTATCTGATAAGAACTCCTCAGTCAATTTAAAAATACAAGTGTTAAAAAACCTCCAGACCTACCTACAAGAAGAA
GATACACGTATGCAGCAGGCAGATAGAGACTGGAAGAAAGTTGCAAAACAGGAAGACTTAAAAGAAATGGGTGATGTTTCCTCAGGGATG
AGTAGTTCCATCATGCAGCTTTATCTCAAACAGGTGCTTGAGGCATTTTTTCACACCCAGTCAAGTGTACGCCACTTTGCCCTAAATGTC
ATTGCATTGACTCTAAATCAAGGTCTTATTCATCCAGTTCAGTGTGTGCCATATTTAATTGCTATGGGCACAGACCCAGAACCTGCTATG
CGGAACAAGGCTGATCAGCAACTTGTGGAAATAGACAAAAAATATGCTGGATTCATTCATATGAAAGCAGTGGCTGGTATGAAGATGTCT
TACCAGGTACAACAGGCAATCAACACATGCCTAAAAGATCCTGTAAGGGGTTTCAGACAAGACGAGTCCTCTAGCGCTTTGTGTTCACAC
CTTTACTCCATGATCCGTGGAAACCGCCAACACAGACGAGCCTTTCTTATTTCTTTACTCAACCTCTTTGATGACACAGCAAAAACAGAC
GTGACTATGCTCTTGTATATAGCAGACAATCTAGCCTGTTTTCCATACCAGACACAGGAAGAGCCGTTGTTTATAATGCATCATATAGAC
ATTACACTCTCAGTTTCTGGTAGTAACCTACTGCAGTCATTCAAGGAGTCTATGGTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCT
AGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAGTCACGGAAACGTGTAGATTCAGATTCAGATTCAGAT
TCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAAAATTCAGCTCCTTTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTA
TTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGATTTTCTGATAGTAAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAA
GTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTTCATCCAAAACAAACACTGGACTTCCTGCGGAGTGACATGGCTAATTCC
AAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTATCTAGATAATCCTGTTCACAAGATTCCTGACTCGCATGAGATAACGCTG
AAGCATGGCACTAAAACAGTGTCTGCTTTGGGTCTGGATCCCTCAGGTGCCCGTTTGGTGACAGGAGGATATGACTATGATGTTAAGTTT
TGGGATTTTGCTGGAATGGATGCTTCTTTTAAGGCATTTCGATCCCTTCAGCCCTGTGAGTGCCATCAGATCAAGTCATTACAGTATAGT
AACACAGGAGACATGATTCTTGTTGTATCTGGAAGCTCTCAGGCCAAGGTGATTGACAGAGATGGTTTTGAAGTAATGGAATGTATAAAA
GGAGACCAGTATATTGTGGACATGGCCAACACCAAGGGTCATACAGCAATGCTTCATACTGGCTCATGGCATCCCAAAATAAAGGGAGAA
TTTATGACTTGCTCAAATGATGCGACTGTGAGGACGTGGGAAGTTGAAAATCCAAAGAAGCAAAAAAGTGTGTTTAAACCACGGACGATG
CAAGGCAAAAAAGTCATTCCCACTACGTGCACATATAGTAGAGATGGAAACCTCATAGCAGCTGCCTGCCAGAATGGAAGCATACAGATC
TGGGACCGAAATTTGACTAGCAACAAGTTAAGACTGTCATATGGAACTGTCTGCATGCTCTGGGCTCACACTGAAGTTTGTGTGATGTGA
ATCCACTGGACTCTATAACTTTTAAGGTTCATCCTAAGTTCCACTATAAACAGGCTCATGACTCGGGCACAGACACTTCTTGCGTGACTT
TTTCCTATGATGGTAATGTCCTTGCCTCTCGTGGAGGTAGGTTAAAAGCTTTCTTTTTGATGTATTTCTCTATATAAAATAATCATCTTT
AACAAATATGACAATAATATCCTAGTGCTTAGTAAAGCTTGCTTTGATTTTTGTTAATGCACCTTTGCCAGTCTGATTTCTTCATTAAAA

>59215_59215_4_NIPBL-WDR70_NIPBL_chr5_37061120_ENST00000448238_WDR70_chr5_37438024_ENST00000504564_length(amino acids)=2843AA_BP=0
MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEG
DIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP
QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASF
PLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTL
RLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQT
SVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM
VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRL
VETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG
HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSV
SESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS
NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIG
LVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVN
EKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVAR
KMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTD
KTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERVIQYTKFHLQNTLYP
QYDPVYRLDPHGGGLLSSKAKRAKCSTHKQRVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA
VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQCVVHLPSSEKDSNAEEDSNKKIDQDVVITNS
YETAMRTAQNFLSIFLKKCGSKQGEEDYRPLFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVHQFSNKSTEMALRVASLDYLGTVAARL
RKDAVTSKMDQGSIERILKQVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQKDEESSEGTHHAKEI
ETTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVV
AVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDICIEQPTFPKITEMCV
KMIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVE
HILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVVPLMEHPSETFLATIE
EDLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLED
FKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLKNLQTYLQEEDTRMQQ
ADRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQ
QLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLNLFDDTAKTDVTMLLY
IADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDIN
SVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEV
KRSIVKQYLDNPVHKIPDSHEITLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDASFKAFRSLQPCECHQIKSLQYSNTGDMI
LVVSGSSQAKVIDRDGFEVMECIKGDQYIVDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRTWEVENPKKQKSVFKPRTMQGKKVI

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Fusion Gene PPI Analysis for NIPBL-WDR70


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NIPBL-WDR70


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NIPBL-WDR70


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource