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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NKD1-ADCY7 (FusionGDB2 ID:59264)

Fusion Gene Summary for NKD1-ADCY7

check button Fusion gene summary
Fusion gene informationFusion gene name: NKD1-ADCY7
Fusion gene ID: 59264
HgeneTgene
Gene symbol

NKD1

ADCY7

Gene ID

85407

113

Gene nameNKD inhibitor of WNT signaling pathway 1adenylate cyclase 7
SynonymsNaked1AC7
Cytomap

16q12.1

16q12.1

Type of geneprotein-codingprotein-coding
Descriptionprotein naked cuticle homolog 1Dvl-binding proteinNKD1, WNT signaling pathway inhibitornaked cuticle homolog 1naked cuticle-1naked-1adenylate cyclase type 7ATP pyrophosphate-lyase 7adenylate cyclase type VIIadenylyl cyclase 7
Modification date2020031320200313
UniProtAcc

Q969G9

P51828

Ensembl transtripts involved in fusion geneENST00000564336, ENST00000268459, 
ENST00000254235, ENST00000394697, 
ENST00000537579, ENST00000538642, 
ENST00000564044, ENST00000566433, 
Fusion gene scores* DoF score7 X 4 X 6=1685 X 7 X 2=70
# samples 85
** MAII scorelog2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/70*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NKD1 [Title/Abstract] AND ADCY7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNKD1(50583466)-ADCY7(50321823), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneADCY7

GO:0006171

cAMP biosynthetic process

11113152|17760784

TgeneADCY7

GO:0071361

cellular response to ethanol

12454008|17760784


check buttonFusion gene breakpoints across NKD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ADCY7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8678-01ANKD1chr16

50583466

-ADCY7chr16

50321823

+
ChimerDB4STADTCGA-BR-8678-01ANKD1chr16

50583466

+ADCY7chr16

50321823

+
ChimerDB4STADTCGA-BR-8678-01ANKD1chr16

50583466

+ADCY7chr16

50326587

+
ChimerDB4STADTCGA-BR-8678NKD1chr16

50583466

+ADCY7chr16

50321822

+
ChimerDB4STADTCGA-BR-8678NKD1chr16

50583466

+ADCY7chr16

50326586

+


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Fusion Gene ORF analysis for NKD1-ADCY7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000564336ENST00000254235NKD1chr16

50583466

+ADCY7chr16

50326587

+
3UTR-3UTRENST00000564336ENST00000254235NKD1chr16

50583466

+ADCY7chr16

50326586

+
3UTR-3UTRENST00000564336ENST00000394697NKD1chr16

50583466

+ADCY7chr16

50326587

+
3UTR-3UTRENST00000564336ENST00000394697NKD1chr16

50583466

+ADCY7chr16

50326586

+
3UTR-3UTRENST00000564336ENST00000537579NKD1chr16

50583466

+ADCY7chr16

50326587

+
3UTR-3UTRENST00000564336ENST00000537579NKD1chr16

50583466

+ADCY7chr16

50326586

+
3UTR-3UTRENST00000564336ENST00000538642NKD1chr16

50583466

+ADCY7chr16

50326587

+
3UTR-3UTRENST00000564336ENST00000538642NKD1chr16

50583466

+ADCY7chr16

50326586

+
3UTR-3UTRENST00000564336ENST00000564044NKD1chr16

50583466

+ADCY7chr16

50326587

+
3UTR-3UTRENST00000564336ENST00000564044NKD1chr16

50583466

+ADCY7chr16

50326586

+
3UTR-3UTRENST00000564336ENST00000566433NKD1chr16

50583466

+ADCY7chr16

50326587

+
3UTR-3UTRENST00000564336ENST00000566433NKD1chr16

50583466

+ADCY7chr16

50326586

+
3UTR-5UTRENST00000564336ENST00000254235NKD1chr16

50583466

+ADCY7chr16

50321823

+
3UTR-5UTRENST00000564336ENST00000254235NKD1chr16

50583466

+ADCY7chr16

50321822

+
3UTR-5UTRENST00000564336ENST00000394697NKD1chr16

50583466

+ADCY7chr16

50321823

+
3UTR-5UTRENST00000564336ENST00000394697NKD1chr16

50583466

+ADCY7chr16

50321822

+
3UTR-5UTRENST00000564336ENST00000537579NKD1chr16

50583466

+ADCY7chr16

50321823

+
3UTR-5UTRENST00000564336ENST00000537579NKD1chr16

50583466

+ADCY7chr16

50321822

+
3UTR-5UTRENST00000564336ENST00000538642NKD1chr16

50583466

+ADCY7chr16

50321823

+
3UTR-5UTRENST00000564336ENST00000538642NKD1chr16

50583466

+ADCY7chr16

50321822

+
3UTR-5UTRENST00000564336ENST00000566433NKD1chr16

50583466

+ADCY7chr16

50321823

+
3UTR-5UTRENST00000564336ENST00000566433NKD1chr16

50583466

+ADCY7chr16

50321822

+
3UTR-intronENST00000564336ENST00000564044NKD1chr16

50583466

+ADCY7chr16

50321823

+
3UTR-intronENST00000564336ENST00000564044NKD1chr16

50583466

+ADCY7chr16

50321822

+
5CDS-3UTRENST00000268459ENST00000254235NKD1chr16

50583466

+ADCY7chr16

50326587

+
5CDS-3UTRENST00000268459ENST00000254235NKD1chr16

50583466

+ADCY7chr16

50326586

+
5CDS-3UTRENST00000268459ENST00000394697NKD1chr16

50583466

+ADCY7chr16

50326587

+
5CDS-3UTRENST00000268459ENST00000394697NKD1chr16

50583466

+ADCY7chr16

50326586

+
5CDS-3UTRENST00000268459ENST00000537579NKD1chr16

50583466

+ADCY7chr16

50326587

+
5CDS-3UTRENST00000268459ENST00000537579NKD1chr16

50583466

+ADCY7chr16

50326586

+
5CDS-3UTRENST00000268459ENST00000538642NKD1chr16

50583466

+ADCY7chr16

50326587

+
5CDS-3UTRENST00000268459ENST00000538642NKD1chr16

50583466

+ADCY7chr16

50326586

+
5CDS-3UTRENST00000268459ENST00000564044NKD1chr16

50583466

+ADCY7chr16

50326587

+
5CDS-3UTRENST00000268459ENST00000564044NKD1chr16

50583466

+ADCY7chr16

50326586

+
5CDS-3UTRENST00000268459ENST00000566433NKD1chr16

50583466

+ADCY7chr16

50326587

+
5CDS-3UTRENST00000268459ENST00000566433NKD1chr16

50583466

+ADCY7chr16

50326586

+
5CDS-5UTRENST00000268459ENST00000254235NKD1chr16

50583466

+ADCY7chr16

50321823

+
5CDS-5UTRENST00000268459ENST00000254235NKD1chr16

50583466

+ADCY7chr16

50321822

+
5CDS-5UTRENST00000268459ENST00000394697NKD1chr16

50583466

+ADCY7chr16

50321823

+
5CDS-5UTRENST00000268459ENST00000394697NKD1chr16

50583466

+ADCY7chr16

50321822

+
5CDS-5UTRENST00000268459ENST00000537579NKD1chr16

50583466

+ADCY7chr16

50321823

+
5CDS-5UTRENST00000268459ENST00000537579NKD1chr16

50583466

+ADCY7chr16

50321822

+
5CDS-5UTRENST00000268459ENST00000538642NKD1chr16

50583466

+ADCY7chr16

50321823

+
5CDS-5UTRENST00000268459ENST00000538642NKD1chr16

50583466

+ADCY7chr16

50321822

+
5CDS-5UTRENST00000268459ENST00000566433NKD1chr16

50583466

+ADCY7chr16

50321823

+
5CDS-5UTRENST00000268459ENST00000566433NKD1chr16

50583466

+ADCY7chr16

50321822

+
5CDS-intronENST00000268459ENST00000564044NKD1chr16

50583466

+ADCY7chr16

50321823

+
5CDS-intronENST00000268459ENST00000564044NKD1chr16

50583466

+ADCY7chr16

50321822

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NKD1-ADCY7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NKD1chr1650583466+ADCY7chr1650326586+0.120006050.8799939
NKD1chr1650583466+ADCY7chr1650326586+0.120006050.8799939
NKD1chr1650583466+ADCY7chr1650321821+0.0132217450.98677826
NKD1chr1650583466+ADCY7chr1650321821+0.0132217450.98677826
NKD1chr1650583466+ADCY7chr1650326586+0.120006050.8799939
NKD1chr1650583466+ADCY7chr1650326586+0.120006050.8799939
NKD1chr1650583466+ADCY7chr1650321821+0.0132217450.98677826
NKD1chr1650583466+ADCY7chr1650321821+0.0132217450.98677826

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NKD1-ADCY7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:50583466/:50321823)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NKD1

Q969G9

ADCY7

P51828

FUNCTION: Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. {ECO:0000269|PubMed:11752446, ECO:0000269|PubMed:15687260, ECO:0000269|PubMed:16567647}.FUNCTION: Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (PubMed:23229509, PubMed:18541530). Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13) (By similarity). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex (PubMed:23842570, PubMed:23229509). Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells (By similarity). {ECO:0000250|UniProtKB:P51829, ECO:0000269|PubMed:18541530, ECO:0000269|PubMed:23229509, ECO:0000269|PubMed:23842570, ECO:0000305|PubMed:18541530, ECO:0000305|PubMed:23229509}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NKD1-ADCY7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NKD1-ADCY7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NKD1-ADCY7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NKD1-ADCY7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource