|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:NKD1-PAPD5 (FusionGDB2 ID:59270) |
Fusion Gene Summary for NKD1-PAPD5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NKD1-PAPD5 | Fusion gene ID: 59270 | Hgene | Tgene | Gene symbol | NKD1 | PAPD5 | Gene ID | 85407 | 64282 |
| Gene name | NKD inhibitor of WNT signaling pathway 1 | terminal nucleotidyltransferase 4B | |
| Synonyms | Naked1 | PAPD5|TRF4-2|TUT3 | |
| Cytomap | 16q12.1 | 16q12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein naked cuticle homolog 1Dvl-binding proteinNKD1, WNT signaling pathway inhibitornaked cuticle homolog 1naked cuticle-1naked-1 | terminal nucleotidyltransferase 4BPAP associated domain containing 5PAP-associated domain-containing protein 5TUTase 3non-canonical poly(A) RNA polymerase PAPD5poly(A) RNA polymerase D5, non-canonicalterminal guanylyltransferaseterminal nucleotidyl | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q969G9 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000564336, ENST00000268459, | ENST00000357464, ENST00000436909, ENST00000561678, ENST00000573002, | |
| Fusion gene scores | * DoF score | 7 X 4 X 6=168 | 8 X 10 X 3=240 |
| # samples | 8 | 9 | |
| ** MAII score | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/240*10)=-1.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NKD1 [Title/Abstract] AND PAPD5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | NKD1(50583466)-PAPD5(50248131), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PAPD5 | GO:0006378 | mRNA polyadenylation | 28383716 |
| Tgene | PAPD5 | GO:0010587 | miRNA catabolic process | 25049417 |
| Tgene | PAPD5 | GO:0043629 | ncRNA polyadenylation | 25049417 |
| Tgene | PAPD5 | GO:0071050 | snoRNA polyadenylation | 22442037 |
| Fusion gene breakpoints across NKD1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across PAPD5 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-BR-8678 | NKD1 | chr16 | 50583466 | + | PAPD5 | chr16 | 50248131 | + |
Top |
Fusion Gene ORF analysis for NKD1-PAPD5 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000564336 | ENST00000357464 | NKD1 | chr16 | 50583466 | + | PAPD5 | chr16 | 50248131 | + |
| 3UTR-3CDS | ENST00000564336 | ENST00000436909 | NKD1 | chr16 | 50583466 | + | PAPD5 | chr16 | 50248131 | + |
| 3UTR-3CDS | ENST00000564336 | ENST00000561678 | NKD1 | chr16 | 50583466 | + | PAPD5 | chr16 | 50248131 | + |
| 3UTR-3CDS | ENST00000564336 | ENST00000573002 | NKD1 | chr16 | 50583466 | + | PAPD5 | chr16 | 50248131 | + |
| In-frame | ENST00000268459 | ENST00000357464 | NKD1 | chr16 | 50583466 | + | PAPD5 | chr16 | 50248131 | + |
| In-frame | ENST00000268459 | ENST00000436909 | NKD1 | chr16 | 50583466 | + | PAPD5 | chr16 | 50248131 | + |
| In-frame | ENST00000268459 | ENST00000561678 | NKD1 | chr16 | 50583466 | + | PAPD5 | chr16 | 50248131 | + |
| In-frame | ENST00000268459 | ENST00000573002 | NKD1 | chr16 | 50583466 | + | PAPD5 | chr16 | 50248131 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000268459 | NKD1 | chr16 | 50583466 | + | ENST00000436909 | PAPD5 | chr16 | 50248131 | + | 4299 | 416 | 134 | 1795 | 553 |
| ENST00000268459 | NKD1 | chr16 | 50583466 | + | ENST00000561678 | PAPD5 | chr16 | 50248131 | + | 2742 | 416 | 134 | 1666 | 510 |
| ENST00000268459 | NKD1 | chr16 | 50583466 | + | ENST00000357464 | PAPD5 | chr16 | 50248131 | + | 7778 | 416 | 134 | 1795 | 553 |
| ENST00000268459 | NKD1 | chr16 | 50583466 | + | ENST00000573002 | PAPD5 | chr16 | 50248131 | + | 4170 | 416 | 510 | 1325 | 271 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000268459 | ENST00000436909 | NKD1 | chr16 | 50583466 | + | PAPD5 | chr16 | 50248131 | + | 0.000164548 | 0.9998354 |
| ENST00000268459 | ENST00000561678 | NKD1 | chr16 | 50583466 | + | PAPD5 | chr16 | 50248131 | + | 0.000585235 | 0.9994148 |
| ENST00000268459 | ENST00000357464 | NKD1 | chr16 | 50583466 | + | PAPD5 | chr16 | 50248131 | + | 0.000138168 | 0.99986184 |
| ENST00000268459 | ENST00000573002 | NKD1 | chr16 | 50583466 | + | PAPD5 | chr16 | 50248131 | + | 0.00094383 | 0.99905616 |
Top |
Fusion Genomic Features for NKD1-PAPD5 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| NKD1 | chr16 | 50583466 | + | PAPD5 | chr16 | 50248136 | + | 0.2559445 | 0.7440555 |
| NKD1 | chr16 | 50583466 | + | PAPD5 | chr16 | 50248136 | + | 0.2559445 | 0.7440555 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
 |
Top |
Fusion Protein Features for NKD1-PAPD5 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:50583466/chr16:50248131) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NKD1 | . |
| FUNCTION: Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. {ECO:0000269|PubMed:11752446, ECO:0000269|PubMed:15687260, ECO:0000269|PubMed:16567647}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | PAPD5 | chr16:50583466 | chr16:50248131 | ENST00000436909 | 2 | 13 | 447_525 | 239 | 699.0 | Compositional bias | Note=Ser-rich | |
| Tgene | PAPD5 | chr16:50583466 | chr16:50248131 | ENST00000436909 | 2 | 13 | 308_368 | 239 | 699.0 | Domain | Note=PAP-associated | |
| Tgene | PAPD5 | chr16:50583466 | chr16:50248131 | ENST00000436909 | 2 | 13 | 557_563 | 239 | 699.0 | Motif | Note=Basic%2C involved in binding of the RNA primer |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NKD1 | chr16:50583466 | chr16:50248131 | ENST00000268459 | + | 3 | 10 | 144_155 | 64 | 471.0 | Calcium binding | Ontology_term=ECO:0000255 |
| Hgene | NKD1 | chr16:50583466 | chr16:50248131 | ENST00000268459 | + | 3 | 10 | 452_466 | 64 | 471.0 | Compositional bias | Note=His-rich |
| Hgene | NKD1 | chr16:50583466 | chr16:50248131 | ENST00000268459 | + | 3 | 10 | 131_166 | 64 | 471.0 | Domain | EF-hand |
| Tgene | PAPD5 | chr16:50583466 | chr16:50248131 | ENST00000436909 | 2 | 13 | 28_32 | 239 | 699.0 | Compositional bias | Note=Poly-Asn | |
| Tgene | PAPD5 | chr16:50583466 | chr16:50248131 | ENST00000436909 | 2 | 13 | 45_76 | 239 | 699.0 | Compositional bias | Note=Pro/Ser-rich |
Top |
Fusion Gene Sequence for NKD1-PAPD5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >59270_59270_1_NKD1-PAPD5_NKD1_chr16_50583466_ENST00000268459_PAPD5_chr16_50248131_ENST00000357464_length(transcript)=7778nt_BP=416nt GCCAATGGGCGCGCGGGGAGGCGCGGGCCGCGGCGGCGGGCTGGGGGCTCGGCGCTCCCGGGCGTCAGTCGGGCCGCGGCGACGGCGGCA GGAGCGCGTCCCGGCGCCGCCTCGGGCTCCGCTCGGCTCGGGGGCTGCTTCGGGAGGAGGAGAGCCAAGGGAGGCGCCAGGCCCGCGGGC CGGGCGCATGGCTTAGGGACGCTCCCGGCCGCCGCAGCCCCAGCATGGGGAAACTTCACTCCAAGCCGGCCGCCGTGTGCAAGCGCAGGG AGAGCCCGGAAGGTGACAGCTTCGCCGTGAGCGCTGCCTGGGCTCGGAAGGGCATCGAGGAGTGGATCGGGAGACAGCGCTGCCCGGGCG GTGTCTCGGGACCCCGACAGCTGCGGTTGGCGGGCACCATAGGCCGAAGCACCCGGGTCCAGATATTTGGAAGTTTTAAAACTGGACTTT ATTTACCTACTAGTGACATCGACCTAGTGGTGTTTGGGAAGTGGGAGAACCTACCCCTCTGGACTCTGGAAGAAGCTCTTCGGAAACACA AAGTCGCAGATGAGGATTCGGTGAAAGTTTTAGACAAAGCAACTGTACCTATTATTAAATTAACAGATTCTTTTACTGAAGTGAAAGTTG ATATCAGCTTTAATGTACAGAATGGCGTGAGAGCAGCTGACCTCATCAAAGATTTTACCAAGAAATATCCTGTATTGCCATACTTGGTTT TAGTATTGAAACAATTCCTATTGCAGAGGGACCTTAATGAAGTATTTACAGGTGGAATTGGTTCTTATAGTCTCTTTTTAATGGCAGTCA GTTTCCTTCAGTTACATCCCAGGGAAGATGCTTGCATCCCCAATACAAACTATGGTGTTCTCTTAATAGAATTTTTTGAATTATATGGAC GACACTTCAATTATTTAAAGACTGGCATCCGGATAAAGGATGGTGGTTCATATGTGGCCAAAGATGAAGTACAGAAAAATATGCTAGATG GCTACAGGCCATCAATGCTTTATATCGAAGATCCTTTACAACCAGGTAACGATGTTGGAAGGAGTTCATATGGGGCCATGCAAGTGAAGC AGGCCTTTGATTATGCCTACGTTGTTTTGAGTCATGCTGTATCACCAATAGCAAAGTACTATCCCAACAATGAAACAGAAAGCATACTAG GTAGAATAATTAGAGTAACAGATGAAGTTGCCACATATAGAGATTGGATATCAAAGCAGTGGGGCTTGAAGAATAGACCTGAGCCTTCAT GCAATGGAAATGGTGTTACCTTGATAGTAGATACTCAGCAGTTAGATAAATGTAATAATAATCTATCTGAAGAAAATGAAGCCCTTGGAA AATGTAGAAGTAAAACCTCGGAATCTCTTAGTAAACACTCTTCAAACTCTTCATCAGGTCCAGTGTCGTCCTCTTCTGCCACACAGTCCA GCTCTAGTGATGTAGATTCCGATGCAACACCATGCAAAACCCCGAAACAGCTGCTTTGCCGTCCGTCCACTGGGAACCGAGTAGGGTCGC AAGATGTATCCTTGGAGTCCTCTCAGGCAGTTGGGAAAATGCAAAGCACCCAAACCACTAACACATCCAACAGCACCAACAAATCTCAGC ATGGATCAGCAAGGCTCTTTCGTTCTTCCAGCAAAGGCTTCCAAGGTACAACTCAAACAAGCCATGGTTCCTTGATGACAAACAAACAAC ATCAAGGCAAATCCAATAATCAGTATTACCATGGCAAAAAGAGGAAACACAAGAGGGACGCGCCCCTCTCAGACCTCTGTAGATAGTCAG CGCTGCGCGGTGGACTGTCTTCTCTGTGCAATGATCTCATGCTCAGGACAGTTGCGCAGGGACTCCTGGGAGATATTCAGGAGCCTCACA CTGTTCAGACGTTGACTTAGCAACTGCGTTTTTTCCCAGCTCGCCACAGAATGGATCATGAAGACTGACAACTGCAAAAAAAACAAAACA AAACAAAAAAAAAAGCAAGCAAAAAAGAGGGAAAAAAAAGGCTGCTTATTTGATAAGTCATATGCTACAACAGGGTCATTTTAAGATTTA AAGCTTGAATGTAAAATAAATATATTTCTCATTGGCTTTATGCAGAGTTATAGGGAATAGTATTCAGTGTTGGTAGGGTGATAGAAACAA AAAACAGTATCAGAGGATGAGGTGGGGAAGGAAAACAAAGGTATCTGATAGGAAGTCCAGATTCCAAAGGGGAAAGTGATCTGTGCATGT TTTTTTTTTAAATATTTTTGCATATATTTACCATTTTATTGTGTGTATATATAGAAGACCATATAGGAGATTGATATTTGTAATAGTGGA TTTGTTAATAATACTTTTTACATAACATTACTGTTTAAATTGTAAACAGATTTTTTCTCAGGATTAGTTTGAAAAATAATCTAAATTGTC ATCTTAACATCCATATATAGGGAAGTGATTAGTTCTATTACTCAATTTGTTTTTCTCAGCATTGAAATGACTTAATAGAACCCTTGTGTC CTGCTGCAAAAATTTTTCCTCTCTAAAGAAAAGGTTTATGGTGGCAAATGATGTTTATTTTATTTTGTAAAAAAAAAAAAATGTACTATG TACTTTTGTGTAAACACTGAAAAATCTCTGGTCATCTCCGAGAATTAACTTGCAACTGTTTTCTATAGTGCTGTCGTCTTGGGCAATGGG CAATTACATGACTTTGTGTTTGCTTCCTTTGCAGTCTTTTTTTTTTCCCCCCATTTCTTCCTAATAGGAAAAAAAAAAAAAAAAAGGTCA CCCATGTCTGGTCTCATTCCTGTTGCAGTGAAACTTCGAGTTCCACAGACTTTGCATGCTGGCTTCTCTAACCCTGTGTGCTGCGTGTGC CTGTTTCTCATCTCTTATTCTTTTTAAAATTCATGCTTAACTACTGTGGGAGAATAACTGTAAACAGCTTTAATTAAATCATACTTATAA AAAACTATTTTCTTATATTCCACTCTATGCTTTTGGTATTGTTGATCTTTACAAATTAAATGGTCTTTGATAATGGATCTATTTTGTATT GCCTTATTAAGACCAAATACTTCTTGTCATCCCATTCTTTATCCTCTTCTTTCATGGAATTGTTATCGTTAATTAAAACTTTTTTAAACA TTGGCTTGTTTCAATCATACTGTAAATTTTGGTTGTAGTCAGCTTTGAGTGCAATGAGATGTATAATTCTGTTATCATTACCTGTTGAGT TTGAAACTCAGTTGGGAATATTTAATATAATAGAATGTAAGTGACATTTCTGAAAATGCTTTCTTTCAGGGTGAAAGCTCTTATGTTTAG CATCAATGTGTATGGCTCTGTTAAATGCAGCCATTTCTGAGACGAGATTCTTTTATATATATATACATATAAAGTACTATTGGCTTTTAG GAGTTTCTTTTATATACATTTATGAAATACTGAAGACCAATCAGACCATTAATGGACACTTAGTGTAACTTTTTATAAAGAAAATAATGC TAAAGTAAGACCAAAACTGATGTCATCACTGAAATTAACAATTTTCAATATGTTCATATTTTAATTCACAATGGAAAAATGTGTTCCAAA ACTGGAAACTCATAGTACTCGTGTAAACTGTGGAAGATTTCAAATGTGATGTTATTTTGACAATGTTTTAAATTTTAGAGTCACATTTTA TTCTGATCAGAATTTTTATTGAGATGTTGAGCTTTTGTTTTTGAAACTAGTTTGTCATAACATTGTGCATAATCACAGTATTTATTTTCT AGGACAATTGTGAATGTGTAGACTTATGTTTACTGCTAAGGGAACAATTATTTATAAAATAATATTAAATCCAGTATTAGCTGCCTATTT CAGACACTTAATACTTGCAGAGATCTATGTTACATTTACCACACTGAAGTTTTTTTTGTTGTTTTTTGTTTGTTTTTAAAGAATCACCCT CATTGTTGAAAGTAAATGTACTCTTAGGGTGCGAATATTAGTGTTCCAATAAGCATGTGATTATATTAAGGTGGTGGTAGCGGGAAGATA ATTCTGATTCCATTGGGAATCTTAGGTTTTCGTAAATTTATTGGGAAAATAGTTTTTCCTGTACTGCTGAAGTTTCTTTTTGGTAAACAG TATCTTTCTAAAAGAAAAAAGCATGAAGGAGAAATTGAGGTGTGTATACATTTCCTCAAATGACCAGCATTGTATTCGTGAATACTGTGT ATCTTGCAGTGAACAGTGTGGAAGCTGTTCATTTTTCAATCTGAAGTAAAATACTTTCAAGAACTTTTAGTTTGCCTGCTCATTTGTTTT ATACATTTCATCTATTTGACTCCTATCTTATTTCTTTTTTGAGTTTTAATACTTCCTATATTTTGTGAATATATCAGAAATGTGTCATTT ATATATTAGAGTCCATTCATATCCATGAATCATAACCTTCCTTTGCTAATACTTGTTGAATGGGATTTTACAAATTCTCCCTCACTCTGG TGACATTTCTCAGGCAGTCATGTATGTGTACCTGGCCATTAGAAATATTAATATTTAAAGACTGTTTTTTAGAGGAGCTGATGGGTTGGT GAGGTGTCAGCACAAAATCTTACTGGTTATGTTTTGATGATAAAAGTATATCCATTTTTTCCCTCCAGCTTTAAGGTGACTGTGAAGGTG CCTGGTTTTGAATGTCTTTGTTTGGTTTGGAGATGTCGCACTCAGTTTTCAAATCTAGCTTGGATCTGTAGGACCTATGTTTTTTACAAG TAATTGCCCTCCAGTCTTCAACAGTTGATTCTGTTTTATTTTTATCCTGTTTTGAGTGTACTTTACCTTTACTTGCATTTTGAGCCTCAT TAATATTTAGGTTATTTGATTTGGCTCCAGATATTCCTAGATCTGCACAGGGCAAAACATGGGCTATAGGGTGAGCATTTTTAATTGTCT TTTTCTGCTGGAACCTTATATCTCTCCATGTGTTTTCTGCTCCTTCCCTCCCCCATGAAATGGTAAGTGTGACTTGTGTTTGCCTGAACC TGTGGACTAGTGTTTGGGGTTTCTGGAAACACTAGAGGGTCAGAAAAGAGTAATGACCACCGTGACGTGCAGGATTCTCTTGCTGTGACA TGTTCATTGCAAAGCCCTCTCCAGTGACTAGGAGGTGTAGTTATTAAGGTTGATCTGTTAGAAATCACCATTATTAGGTATTAGTGGTAG ATGTTGCTGATACTTTTATTGGTCATGACTACATCTCAGTTTTACTTTAATATTGATCTATAGTTTGATCAGTTCCTTGAATTCTAATAT GTTGATTTCTCAGTGTTTCTGTCACTAACCAAGAATGTTTCTAGGCAGTTGGTTGCTTCACAGTCAAAACTAAATGGTAAACTATCAAAA ATACATTCCCAATTTTGCTGTGATAAATATTGAAATGTTAAAATTAATGAACAGAAGAATTTATTCTTACCCATCTATTCTTGTTCTCCT AGTTCATTAAACTTTCAGTTATTGGAAAGGCACATTCTCAAAGTATTTTATGAGCAAAATATTCTATAAATGCGTCTAACAAACCTAATT GAATATAAAAGTTATATTTAGTAGTTACTGTTGATAGTAATTTTCATCAGGGTCATAGTTCATCTAGTAAAATATTTAGAGAATGATGTT AACATTCCAGCATTAAAGTGGGAACAAAGATTTATATATGAAATTCCTTAAAAGAGTTCATCTTGCCTTGGTTTCTGACCCTCAAGACTC TAGCTACCTGCCATCTTGTCAAAACATTTGTGGGTAGAATAAGTGTTAAAGATCAAATTTTAATATGCTTCTCGATATTTAACATAGCTA AGAAGCCAGATTTTACTGTAGAAGTTATTTACATGATTTGAAAACTTGACCTAACTGGAAGCCTTTTTCTCAGTCATCTTGTTCTAAGCC ATCTTGACTTCACACCCTTAGCGACTTTTCTTTTTTTTTTGGTCAAAGATAATGAGCTAAATATATATAGACGTTGAATGTTGACAAAAT TATTAACCAGAAAAATTGCTTATAAAGGCTGCTGATCTATTTGATACCTAGAATTAAATATTTGAGGACAGTTTTTAGTTAATAAACTGC TAATGTTTATTTTACTGTCTCTCAGGTTTTTGGTTTTTTTAAAAAAAATGTGTTTGGCCTTTACATTTTCTACTTAAGTGTGTACTTTAT TGAGTTTAACCTTGTCTGTAGCCTAGTAGCCTGAAAGAAAAGGAGACAGAACCAGAGAGATGGATGTAGTGCATTCCCTTTGGTTATTAC ACATTTGTGGTAGCTCCTGGATTTACTGAGAGATATTTTAGCTATGTCAATAAGAACAGCTAATGATGTGGAAATCAGGTGTTCTCTTGT GTATTTCAGTGAACATTTTTATTAGTAGTTGCATATCATCTCTAGTTCCACATTTTAACTTAACGTCTTTGTGGCTTCACCACTGAGCTA CCTTTCACTACACCAGCTTCTGTGTGGCCTGGTAACATGGAAGGTCTCTCCTAAGGACAGTCTGGACGTATTTTGGGGGAATGTTATTTA TCTTAAAGATGCCTAGAAACAAAACGCATATAGTACCAGTGAGAAACTATGAAGTAAACAAGTTGCTCAGGCCGGGCATGGTGGCTCACG CCTGTAATCCCAGCACTTTGGGAGGCCGAAGCGGGAGGATGGCTTGAGGCTGGGAGTTTGAGACCTTCATCTCTTAAAAAAACAAACAAA AACCTGAATGGTGAGGTGTGGTGGAATTGGGTAGGGGAGGGAAAGGAGGACTTGGAAAAGCATTCTCCAAAGCCAGCAACTTGGTGAAGT TCAGTACTTGCCTCTTAGAGGTTAGGCCATGCCTTTCAAAGAGAGTGAAATGATGGGTTATCAGCCACATTCTTGGAGTTAATATTTTTC TTCATCTTTCAGTTTGGGTTCTGTGCTATTCATAGTTCTTCCCTAAGACCATTTCATTATTACCTTTTATATTTAGTTGCAATTTATTAT AATATGTTGTTTTGTCCCTGAACTTAATCTCCTAATTTTAAGATCCTCTCTGATTTTTGCATATTGAAACTTACAGAAGTCACTTTAAAA AAGTCTTTTGAAAGTCCTACAATCCTAAAATAAATCACAAGCTTGTTTGTTAGACGTGTCAAGAGTCTCCAGTCTTTACTACTAAAAAGC AGCACTGCCTTAACACACATTGTTATGGGTGAAAAGTGAGGGACGACCAGTGTAGTTTCTGGATATAAAGTGTGAAGGACTGTTGAGTTA AACATTTTTAGTGGAATATACATAGATAACGTGTATTTAGAAACTTTGGTGAAGCCAGTATTTGTTTTTAGTAACCTTTTTATGTATTTC CTTCTTTGATTAGCATTGTCTTCAGTGTTAAGAAATGTGGACTCCTGTGAGGTGCTGGAGGTTTGAATCATCTTGAAAACTTTCCAATCT TGTCTAGTTACCACTGCAGAGACACTAAGGAATTTACCAGAAAAAGATATTTGATACAAGTGATTTAAGAAATCTCAACATTTCCTGAGG CCGTATCACTGGGCAACCAGTGATGAAAACTATGAATGAATTGCACACCTGGAAGATTTTTTAAGCTAATGACAGTTTCTTCAAAGATGT CAATTATTTGCCTTGGAAATTTTATAAATTGCATTTCTATGCACATCGGCCTCTAGTGCTTACCACTCGGTTTATTATTCATAATCTGCA >59270_59270_1_NKD1-PAPD5_NKD1_chr16_50583466_ENST00000268459_PAPD5_chr16_50248131_ENST00000357464_length(amino acids)=553AA_BP=74 MLREEESQGRRQARGPGAWLRDAPGRRSPSMGKLHSKPAAVCKRRESPEGDSFAVSAAWARKGIEEWIGRQRCPGGVSGPRQLRLAGTIG RSTRVQIFGSFKTGLYLPTSDIDLVVFGKWENLPLWTLEEALRKHKVADEDSVKVLDKATVPIIKLTDSFTEVKVDISFNVQNGVRAADL IKDFTKKYPVLPYLVLVLKQFLLQRDLNEVFTGGIGSYSLFLMAVSFLQLHPREDACIPNTNYGVLLIEFFELYGRHFNYLKTGIRIKDG GSYVAKDEVQKNMLDGYRPSMLYIEDPLQPGNDVGRSSYGAMQVKQAFDYAYVVLSHAVSPIAKYYPNNETESILGRIIRVTDEVATYRD WISKQWGLKNRPEPSCNGNGVTLIVDTQQLDKCNNNLSEENEALGKCRSKTSESLSKHSSNSSSGPVSSSSATQSSSSDVDSDATPCKTP KQLLCRPSTGNRVGSQDVSLESSQAVGKMQSTQTTNTSNSTNKSQHGSARLFRSSSKGFQGTTQTSHGSLMTNKQHQGKSNNQYYHGKKR -------------------------------------------------------------- >59270_59270_2_NKD1-PAPD5_NKD1_chr16_50583466_ENST00000268459_PAPD5_chr16_50248131_ENST00000436909_length(transcript)=4299nt_BP=416nt GCCAATGGGCGCGCGGGGAGGCGCGGGCCGCGGCGGCGGGCTGGGGGCTCGGCGCTCCCGGGCGTCAGTCGGGCCGCGGCGACGGCGGCA GGAGCGCGTCCCGGCGCCGCCTCGGGCTCCGCTCGGCTCGGGGGCTGCTTCGGGAGGAGGAGAGCCAAGGGAGGCGCCAGGCCCGCGGGC CGGGCGCATGGCTTAGGGACGCTCCCGGCCGCCGCAGCCCCAGCATGGGGAAACTTCACTCCAAGCCGGCCGCCGTGTGCAAGCGCAGGG AGAGCCCGGAAGGTGACAGCTTCGCCGTGAGCGCTGCCTGGGCTCGGAAGGGCATCGAGGAGTGGATCGGGAGACAGCGCTGCCCGGGCG GTGTCTCGGGACCCCGACAGCTGCGGTTGGCGGGCACCATAGGCCGAAGCACCCGGGTCCAGATATTTGGAAGTTTTAAAACTGGACTTT ATTTACCTACTAGTGACATCGACCTAGTGGTGTTTGGGAAGTGGGAGAACCTACCCCTCTGGACTCTGGAAGAAGCTCTTCGGAAACACA AAGTCGCAGATGAGGATTCGGTGAAAGTTTTAGACAAAGCAACTGTACCTATTATTAAATTAACAGATTCTTTTACTGAAGTGAAAGTTG ATATCAGCTTTAATGTACAGAATGGCGTGAGAGCAGCTGACCTCATCAAAGATTTTACCAAGAAATATCCTGTATTGCCATACTTGGTTT TAGTATTGAAACAATTCCTATTGCAGAGGGACCTTAATGAAGTATTTACAGGTGGAATTGGTTCTTATAGTCTCTTTTTAATGGCAGTCA GTTTCCTTCAGTTACATCCCAGGGAAGATGCTTGCATCCCCAATACAAACTATGGTGTTCTCTTAATAGAATTTTTTGAATTATATGGAC GACACTTCAATTATTTAAAGACTGGCATCCGGATAAAGGATGGTGGTTCATATGTGGCCAAAGATGAAGTACAGAAAAATATGCTAGATG GCTACAGGCCATCAATGCTTTATATCGAAGATCCTTTACAACCAGGTAACGATGTTGGAAGGAGTTCATATGGGGCCATGCAAGTGAAGC AGGCCTTTGATTATGCCTACGTTGTTTTGAGTCATGCTGTATCACCAATAGCAAAGTACTATCCCAACAATGAAACAGAAAGCATACTAG GTAGAATAATTAGAGTAACAGATGAAGTTGCCACATATAGAGATTGGATATCAAAGCAGTGGGGCTTGAAGAATAGACCTGAGCCTTCAT GCAATGGAAATGGTGTTACCTTGATAGTAGATACTCAGCAGTTAGATAAATGTAATAATAATCTATCTGAAGAAAATGAAGCCCTTGGAA AATGTAGAAGTAAAACCTCGGAATCTCTTAGTAAACACTCTTCAAACTCTTCATCAGGTCCAGTGTCGTCCTCTTCTGCCACACAGTCCA GCTCTAGTGATGTAGATTCCGATGCAACACCATGCAAAACCCCGAAACAGCTGCTTTGCCGTCCGTCCACTGGGAACCGAGTAGGGTCGC AAGATGTATCCTTGGAGTCCTCTCAGGCAGTTGGGAAAATGCAAAGCACCCAAACCACTAACACATCCAACAGCACCAACAAATCTCAGC ATGGATCAGCAAGGCTCTTTCGTTCTTCCAGCAAAGGCTTCCAAGGTACAACTCAAACAAGCCATGGTTCCTTGATGACAAACAAACAAC ATCAAGGCAAATCCAATAATCAGTATTACCATGGCAAAAAGAGGAAACACAAGAGGGACGCGCCCCTCTCAGACCTCTGTAGATAGTCAG CGCTGCGCGGTGGACTGTCTTCTCTGTGCAATGATCTCATGCTCAGGACAGTTGCGCAGGGACTCCTGGGAGATATTCAGGAGCCTCACA CTGTTCAGACGTTGACTTAGCAACTGCGTTTTTTCCCAGCTCGCCACAGAATGGATCATGAAGACTGACAACTGCAAAAAAAACAAAACA AAACAAAAAAAAAAGCAAGCAAAAAAGAGGGAAAAAAAAGGCTGCTTATTTGATAAGTCATATGCTACAACAGGGTCATTTTAAGATTTA AAGCTTGAATGTAAAATAAATATATTTCTCATTGGCTTTATGCAGAGTTATAGGGAATAGTATTCAGTGTTGGTAGGGTGATAGAAACAA AAAACAGTATCAGAGGATGAGGTGGGGAAGGAAAACAAAGGTATCTGATAGGAAGTCCAGATTCCAAAGGGGAAAGTGATCTGTGCATGT TTTTTTTTTAAATATTTTTGCATATATTTACCATTTTATTGTGTGTATATATAGAAGACCATATAGGAGATTGATATTTGTAATAGTGGA TTTGTTAATAATACTTTTTACATAACATTACTGTTTAAATTGTAAACAGATTTTTTCTCAGGATTAGTTTGAAAAATAATCTAAATTGTC ATCTTAACATCCATATATAGGGAAGTGATTAGTTCTATTACTCAATTTGTTTTTCTCAGCATTGAAATGACTTAATAGAACCCTTGTGTC CTGCTGCAAAAATTTTTCCTCTCTAAAGAAAAGGTTTATGGTGGCAAATGATGTTTATTTTATTTTGTAAAAAAAAAAAAATGTACTATG TACTTTTGTGTAAACACTGAAAAATCTCTGGTCATCTCCGAGAATTAACTTGCAACTGTTTTCTATAGTGCTGTCGTCTTGGGCAATGGG CAATTACATGACTTTGTGTTTGCTTCCTTTGCAGTCTTTTTTTTTTCCCCCCATTTCTTCCTAATAGGAAAAAAAAAAAAAAAAAGGTCA CCCATGTCTGGTCTCATTCCTGTTGCAGTGAAACTTCGAGTTCCACAGACTTTGCATGCTGGCTTCTCTAACCCTGTGTGCTGCGTGTGC CTGTTTCTCATCTCTTATTCTTTTTAAAATTCATGCTTAACTACTGTGGGAGAATAACTGTAAACAGCTTTAATTAAATCATACTTATAA AAAACTATTTTCTTATATTCCACTCTATGCTTTTGGTATTGTTGATCTTTACAAATTAAATGGTCTTTGATAATGGATCTATTTTGTATT GCCTTATTAAGACCAAATACTTCTTGTCATCCCATTCTTTATCCTCTTCTTTCATGGAATTGTTATCGTTAATTAAAACTTTTTTAAACA TTGGCTTGTTTCAATCATACTGTAAATTTTGGTTGTAGTCAGCTTTGAGTGCAATGAGATGTATAATTCTGTTATCATTACCTGTTGAGT TTGAAACTCAGTTGGGAATATTTAATATAATAGAATGTAAGTGACATTTCTGAAAATGCTTTCTTTCAGGGTGAAAGCTCTTATGTTTAG CATCAATGTGTATGGCTCTGTTAAATGCAGCCATTTCTGAGACGAGATTCTTTTATATATATATACATATAAAGTACTATTGGCTTTTAG GAGTTTCTTTTATATACATTTATGAAATACTGAAGACCAATCAGACCATTAATGGACACTTAGTGTAACTTTTTATAAAGAAAATAATGC TAAAGTAAGACCAAAACTGATGTCATCACTGAAATTAACAATTTTCAATATGTTCATATTTTAATTCACAATGGAAAAATGTGTTCCAAA ACTGGAAACTCATAGTACTCGTGTAAACTGTGGAAGATTTCAAATGTGATGTTATTTTGACAATGTTTTAAATTTTAGAGTCACATTTTA TTCTGATCAGAATTTTTATTGAGATGTTGAGCTTTTGTTTTTGAAACTAGTTTGTCATAACATTGTGCATAATCACAGTATTTATTTTCT AGGACAATTGTGAATGTGTAGACTTATGTTTACTGCTAAGGGAACAATTATTTATAAAATAATATTAAATCCAGTATTAGCTGCCTATTT CAGACACTTAATACTTGCAGAGATCTATGTTACATTTACCACACTGAAGTTTTTTTTGTTGTTTTTTGTTTGTTTTTAAAGAATCACCCT CATTGTTGAAAGTAAATGTACTCTTAGGGTGCGAATATTAGTGTTCCAATAAGCATGTGATTATATTAAGGTGGTGGTAGCGGGAAGATA ATTCTGATTCCATTGGGAATCTTAGGTTTTCGTAAATTTATTGGGAAAATAGTTTTTCCTGTACTGCTGAAGTTTCTTTTTGGTAAACAG TATCTTTCTAAAAGAAAAAAGCATGAAGGAGAAATTGAGGTGTGTATACATTTCCTCAAATGACCAGCATTGTATTCGTGAATACTGTGT >59270_59270_2_NKD1-PAPD5_NKD1_chr16_50583466_ENST00000268459_PAPD5_chr16_50248131_ENST00000436909_length(amino acids)=553AA_BP=74 MLREEESQGRRQARGPGAWLRDAPGRRSPSMGKLHSKPAAVCKRRESPEGDSFAVSAAWARKGIEEWIGRQRCPGGVSGPRQLRLAGTIG RSTRVQIFGSFKTGLYLPTSDIDLVVFGKWENLPLWTLEEALRKHKVADEDSVKVLDKATVPIIKLTDSFTEVKVDISFNVQNGVRAADL IKDFTKKYPVLPYLVLVLKQFLLQRDLNEVFTGGIGSYSLFLMAVSFLQLHPREDACIPNTNYGVLLIEFFELYGRHFNYLKTGIRIKDG GSYVAKDEVQKNMLDGYRPSMLYIEDPLQPGNDVGRSSYGAMQVKQAFDYAYVVLSHAVSPIAKYYPNNETESILGRIIRVTDEVATYRD WISKQWGLKNRPEPSCNGNGVTLIVDTQQLDKCNNNLSEENEALGKCRSKTSESLSKHSSNSSSGPVSSSSATQSSSSDVDSDATPCKTP KQLLCRPSTGNRVGSQDVSLESSQAVGKMQSTQTTNTSNSTNKSQHGSARLFRSSSKGFQGTTQTSHGSLMTNKQHQGKSNNQYYHGKKR -------------------------------------------------------------- >59270_59270_3_NKD1-PAPD5_NKD1_chr16_50583466_ENST00000268459_PAPD5_chr16_50248131_ENST00000561678_length(transcript)=2742nt_BP=416nt GCCAATGGGCGCGCGGGGAGGCGCGGGCCGCGGCGGCGGGCTGGGGGCTCGGCGCTCCCGGGCGTCAGTCGGGCCGCGGCGACGGCGGCA GGAGCGCGTCCCGGCGCCGCCTCGGGCTCCGCTCGGCTCGGGGGCTGCTTCGGGAGGAGGAGAGCCAAGGGAGGCGCCAGGCCCGCGGGC CGGGCGCATGGCTTAGGGACGCTCCCGGCCGCCGCAGCCCCAGCATGGGGAAACTTCACTCCAAGCCGGCCGCCGTGTGCAAGCGCAGGG AGAGCCCGGAAGGTGACAGCTTCGCCGTGAGCGCTGCCTGGGCTCGGAAGGGCATCGAGGAGTGGATCGGGAGACAGCGCTGCCCGGGCG GTGTCTCGGGACCCCGACAGCTGCGGTTGGCGGGCACCATAGGCCGAAGCACCCGGGTCCAGATATTTGGAAGTTTTAAAACTGGACTTT ATTTACCTACTAGTGACATCGACCTAGTGGTGTTTGGGAAGTGGGAGAACCTACCCCTCTGGACTCTGGAAGAAGCTCTTCGGAAACACA AAGTCGCAGATGAGGATTCGGTGAAAGTTTTAGACAAAGCAACTGTACCTATTATTAAATTAACAGATTCTTTTACTGAAGTGAAAGTTG ATATCAGCTTTAATGTACAGAATGGCGTGAGAGCAGCTGACCTCATCAAAGATTTTACCAAGTTACATCCCAGGGAAGATGCTTGCATCC CCAATACAAACTATGGTGTTCTCTTAATAGAATTTTTTGAATTATATGGACGACACTTCAATTATTTAAAGACTGGCATCCGGATAAAGG ATGGTGGTTCATATGTGGCCAAAGATGAAGTACAGAAAAATATGCTAGATGGCTACAGGCCATCAATGCTTTATATCGAAGATCCTTTAC AACCAGGTAACGATGTTGGAAGGAGTTCATATGGGGCCATGCAAGTGAAGCAGGCCTTTGATTATGCCTACGTTGTTTTGAGTCATGCTG TATCACCAATAGCAAAGTACTATCCCAACAATGAAACAGAAAGCATACTAGGTAGAATAATTAGAGTAACAGATGAAGTTGCCACATATA GAGATTGGATATCAAAGCAGTGGGGCTTGAAGAATAGACCTGAGCCTTCATGCAATGGAAATGGTGTTACCTTGATAGTAGATACTCAGC AGTTAGATAAATGTAATAATAATCTATCTGAAGAAAATGAAGCCCTTGGAAAATGTAGAAGTAAAACCTCGGAATCTCTTAGTAAACACT CTTCAAACTCTTCATCAGGTCCAGTGTCGTCCTCTTCTGCCACACAGTCCAGCTCTAGTGATGTAGATTCCGATGCAACACCATGCAAAA CCCCGAAACAGCTGCTTTGCCGTCCGTCCACTGGGAACCGAGTAGGGTCGCAAGATGTATCCTTGGAGTCCTCTCAGGCAGTTGGGAAAA TGCAAAGCACCCAAACCACTAACACATCCAACAGCACCAACAAATCTCAGCATGGATCAGCAAGGCTCTTTCGTTCTTCCAGCAAAGGCT TCCAAGGTACAACTCAAACAAGCCATGGTTCCTTGATGACAAACAAACAACATCAAGGCAAATCCAATAATCAGTATTACCATGGCAAAA AGAGGAAACACAAGAGGGACGCGCCCCTCTCAGACCTCTGTAGATAGTCAGCGCTGCGCGGTGGACTGTCTTCTCTGTGCAATGATCTCA TGCTCAGGACAGTTGCGCAGGGACTCCTGGGAGATATTCAGGAGCCTCACACTGTTCAGACGTTGACTTAGCAACTGCGTTTTTTCCCAG CTCGCCACAGAATGGATCATGAAGACTGACAACTGCAAAAAAAACAAAACAAAACAAAAAAAAAAGCAAGCAAAAAAGAGGGAAAAAAAA GGCTGCTTATTTGATAAGTCATATGCTACAACAGGGTCATTTTAAGATTTAAAGCTTGAATGTAAAATAAATATATTTCTCATTGGCTTT ATGCAGAGTTATAGGGAATAGTATTCAGTGTTGGTAGGGTGATAGAAACAAAAAACAGTATCAGAGGATGAGGTGGGGAAGGAAAACAAA GGTATCTGATAGGAAGTCCAGATTCCAAAGGGGAAAGTGATCTGTGCATGTTTTTTTTTTAAATATTTTTGCATATATTTACCATTTTAT TGTGTGTATATATAGAAGACCATATAGGAGATTGATATTTGTAATAGTGGATTTGTTAATAATACTTTTTACATAACATTACTGTTTAAA TTGTAAACAGATTTTTTCTCAGGATTAGTTTGAAAAATAATCTAAATTGTCATCTTAACATCCATATATAGGGAAGTGATTAGTTCTATT ACTCAATTTGTTTTTCTCAGCATTGAAATGACTTAATAGAACCCTTGTGTCCTGCTGCAAAAATTTTTCCTCTCTAAAGAAAAGGTTTAT GGTGGCAAATGATGTTTATTTTATTTTGTAAAAAAAAAAAAATGTACTATGTACTTTTGTGTAAACACTGAAAAATCTCTGGTCATCTCC GAGAATTAACTTGCAACTGTTTTCTATAGTGCTGTCGTCTTGGGCAATGGGCAATTACATGACTTTGTGTTTGCTTCCTTTGCAGTCTTT TTTTTTTCCCCCCATTTCTTCCTAATAGGAAAAAAAAAAAAAAAAAGGTCACCCATGTCTGGTCTCATTCCTGTTGCAGTGAAACTTCGA >59270_59270_3_NKD1-PAPD5_NKD1_chr16_50583466_ENST00000268459_PAPD5_chr16_50248131_ENST00000561678_length(amino acids)=510AA_BP=74 MLREEESQGRRQARGPGAWLRDAPGRRSPSMGKLHSKPAAVCKRRESPEGDSFAVSAAWARKGIEEWIGRQRCPGGVSGPRQLRLAGTIG RSTRVQIFGSFKTGLYLPTSDIDLVVFGKWENLPLWTLEEALRKHKVADEDSVKVLDKATVPIIKLTDSFTEVKVDISFNVQNGVRAADL IKDFTKLHPREDACIPNTNYGVLLIEFFELYGRHFNYLKTGIRIKDGGSYVAKDEVQKNMLDGYRPSMLYIEDPLQPGNDVGRSSYGAMQ VKQAFDYAYVVLSHAVSPIAKYYPNNETESILGRIIRVTDEVATYRDWISKQWGLKNRPEPSCNGNGVTLIVDTQQLDKCNNNLSEENEA LGKCRSKTSESLSKHSSNSSSGPVSSSSATQSSSSDVDSDATPCKTPKQLLCRPSTGNRVGSQDVSLESSQAVGKMQSTQTTNTSNSTNK -------------------------------------------------------------- >59270_59270_4_NKD1-PAPD5_NKD1_chr16_50583466_ENST00000268459_PAPD5_chr16_50248131_ENST00000573002_length(transcript)=4170nt_BP=416nt GCCAATGGGCGCGCGGGGAGGCGCGGGCCGCGGCGGCGGGCTGGGGGCTCGGCGCTCCCGGGCGTCAGTCGGGCCGCGGCGACGGCGGCA GGAGCGCGTCCCGGCGCCGCCTCGGGCTCCGCTCGGCTCGGGGGCTGCTTCGGGAGGAGGAGAGCCAAGGGAGGCGCCAGGCCCGCGGGC CGGGCGCATGGCTTAGGGACGCTCCCGGCCGCCGCAGCCCCAGCATGGGGAAACTTCACTCCAAGCCGGCCGCCGTGTGCAAGCGCAGGG AGAGCCCGGAAGGTGACAGCTTCGCCGTGAGCGCTGCCTGGGCTCGGAAGGGCATCGAGGAGTGGATCGGGAGACAGCGCTGCCCGGGCG GTGTCTCGGGACCCCGACAGCTGCGGTTGGCGGGCACCATAGGCCGAAGCACCCGGGATATTTGGAAGTTTTAAAACTGGACTTTATTTA CCTACTAGTGACATCGACCTAGTGGTGTTTGGGAAGTGGGAGAACCTACCCCTCTGGACTCTGGAAGAAGCTCTTCGGAAACACAAAGTC GCAGATGAGGATTCGGTGAAAGTTTTAGACAAAGCAACTGTACCTATTATTAAATTAACAGATTCTTTTACTGAAGTGAAAGTTGATATC AGCTTTAATGTACAGAATGGCGTGAGAGCAGCTGACCTCATCAAAGATTTTACCAAGAAATATCCTGTATTGCCATACTTGGTTTTAGTA TTGAAACAATTCCTATTGCAGAGGGACCTTAATGAAGTATTTACAGGTGGAATTGGTTCTTATAGTCTCTTTTTAATGGCAGTCAGTTTC CTTCAGTTACATCCCAGGGAAGATGCTTGCATCCCCAATACAAACTATGGTGTTCTCTTAATAGAATTTTTTGAATTATATGGACGACAC TTCAATTATTTAAAGACTGGCATCCGGATAAAGGATGGTGGTTCATATGTGGCCAAAGATGAAGTACAGAAAAATATGCTAGATGGCTAC AGGCCATCAATGCTTTATATCGAAGATCCTTTACAACCAGGTAACGATGTTGGAAGGAGTTCATATGGGGCCATGCAAGTGAAGCAGGCC TTTGATTATGCCTACGTTGTTTTGAGTCATGCTGTATCACCAATAGCAAAGTACTATCCCAACAATGAAACAGAAAGCATACTAGGTAGA ATAATTAGAGTAACAGATGAAGTTGCCACATATAGAGATTGGATATCAAAGCAGTGGGGCTTGAAGAATAGACCTGAGCCTTCATGCAAT GGTAAGATATTTTCCTTGGTCCAGTGTCGTCCTCTTCTGCCACACAGTCCAGCTCTAGTGATGTAGATTCCGATGCAACACCATGCAAAA CCCCGAAACAGCTGCTTTGCCGTCCGTCCACTGGGAACCGAGTAGGGTCGCAAGATGTATCCTTGGAGTCCTCTCAGGCAGTTGGGAAAA TGCAAAGCACCCAAACCACTAACACATCCAACAGCACCAACAAATCTCAGCATGGATCAGCAAGGCTCTTTCGTTCTTCCAGCAAAGGCT TCCAAGGTACAACTCAAACAAGCCATGGTTCCTTGATGACAAACAAACAACATCAAGGCAAATCCAATAATCAGTATTACCATGGCAAAA AGAGGAAACACAAGAGGGACGCGCCCCTCTCAGACCTCTGTAGATAGTCAGCGCTGCGCGGTGGACTGTCTTCTCTGTGCAATGATCTCA TGCTCAGGACAGTTGCGCAGGGACTCCTGGGAGATATTCAGGAGCCTCACACTGTTCAGACGTTGACTTAGCAACTGCGTTTTTTCCCAG CTCGCCACAGAATGGATCATGAAGACTGACAACTGCAAAAAAAACAAAACAAAACAAAAAAAAAAGCAAGCAAAAAAGAGGGAAAAAAAA GGCTGCTTATTTGATAAGTCATATGCTACAACAGGGTCATTTTAAGATTTAAAGCTTGAATGTAAAATAAATATATTTCTCATTGGCTTT ATGCAGAGTTATAGGGAATAGTATTCAGTGTTGGTAGGGTGATAGAAACAAAAAACAGTATCAGAGGATGAGGTGGGGAAGGAAAACAAA GGTATCTGATAGGAAGTCCAGATTCCAAAGGGGAAAGTGATCTGTGCATGTTTTTTTTTTAAATATTTTTGCATATATTTACCATTTTAT TGTGTGTATATATAGAAGACCATATAGGAGATTGATATTTGTAATAGTGGATTTGTTAATAATACTTTTTACATAACATTACTGTTTAAA TTGTAAACAGATTTTTTCTCAGGATTAGTTTGAAAAATAATCTAAATTGTCATCTTAACATCCATATATAGGGAAGTGATTAGTTCTATT ACTCAATTTGTTTTTCTCAGCATTGAAATGACTTAATAGAACCCTTGTGTCCTGCTGCAAAAATTTTTCCTCTCTAAAGAAAAGGTTTAT GGTGGCAAATGATGTTTATTTTATTTTGTAAAAAAAAAAAAATGTACTATGTACTTTTGTGTAAACACTGAAAAATCTCTGGTCATCTCC GAGAATTAACTTGCAACTGTTTTCTATAGTGCTGTCGTCTTGGGCAATGGGCAATTACATGACTTTGTGTTTGCTTCCTTTGCAGTCTTT TTTTTTTCCCCCCATTTCTTCCTAATAGGAAAAAAAAAAAAAAAAAGGTCACCCATGTCTGGTCTCATTCCTGTTGCAGTGAAACTTCGA GTTCCACAGACTTTGCATGCTGGCTTCTCTAACCCTGTGTGCTGCGTGTGCCTGTTTCTCATCTCTTATTCTTTTTAAAATTCATGCTTA ACTACTGTGGGAGAATAACTGTAAACAGCTTTAATTAAATCATACTTATAAAAAACTATTTTCTTATATTCCACTCTATGCTTTTGGTAT TGTTGATCTTTACAAATTAAATGGTCTTTGATAATGGATCTATTTTGTATTGCCTTATTAAGACCAAATACTTCTTGTCATCCCATTCTT TATCCTCTTCTTTCATGGAATTGTTATCGTTAATTAAAACTTTTTTAAACATTGGCTTGTTTCAATCATACTGTAAATTTTGGTTGTAGT CAGCTTTGAGTGCAATGAGATGTATAATTCTGTTATCATTACCTGTTGAGTTTGAAACTCAGTTGGGAATATTTAATATAATAGAATGTA AGTGACATTTCTGAAAATGCTTTCTTTCAGGGTGAAAGCTCTTATGTTTAGCATCAATGTGTATGGCTCTGTTAAATGCAGCCATTTCTG AGACGAGATTCTTTTATATATATATACATATAAAGTACTATTGGCTTTTAGGAGTTTCTTTTATATACATTTATGAAATACTGAAGACCA ATCAGACCATTAATGGACACTTAGTGTAACTTTTTATAAAGAAAATAATGCTAAAGTAAGACCAAAACTGATGTCATCACTGAAATTAAC AATTTTCAATATGTTCATATTTTAATTCACAATGGAAAAATGTGTTCCAAAACTGGAAACTCATAGTACTCGTGTAAACTGTGGAAGATT TCAAATGTGATGTTATTTTGACAATGTTTTAAATTTTAGAGTCACATTTTATTCTGATCAGAATTTTTATTGAGATGTTGAGCTTTTGTT TTTGAAACTAGTTTGTCATAACATTGTGCATAATCACAGTATTTATTTTCTAGGACAATTGTGAATGTGTAGACTTATGTTTACTGCTAA GGGAACAATTATTTATAAAATAATATTAAATCCAGTATTAGCTGCCTATTTCAGACACTTAATACTTGCAGAGATCTATGTTACATTTAC CACACTGAAGTTTTTTTTGTTGTTTTTTGTTTGTTTTTAAAGAATCACCCTCATTGTTGAAAGTAAATGTACTCTTAGGGTGCGAATATT AGTGTTCCAATAAGCATGTGATTATATTAAGGTGGTGGTAGCGGGAAGATAATTCTGATTCCATTGGGAATCTTAGGTTTTCGTAAATTT ATTGGGAAAATAGTTTTTCCTGTACTGCTGAAGTTTCTTTTTGGTAAACAGTATCTTTCTAAAAGAAAAAAGCATGAAGGAGAAATTGAG GTGTGTATACATTTCCTCAAATGACCAGCATTGTATTCGTGAATACTGTGTATCTTGCAGTGAACAGTGTGGAAGCTGTTCATTTTTCAA >59270_59270_4_NKD1-PAPD5_NKD1_chr16_50583466_ENST00000268459_PAPD5_chr16_50248131_ENST00000573002_length(amino acids)=271AA_BP= MEEALRKHKVADEDSVKVLDKATVPIIKLTDSFTEVKVDISFNVQNGVRAADLIKDFTKKYPVLPYLVLVLKQFLLQRDLNEVFTGGIGS YSLFLMAVSFLQLHPREDACIPNTNYGVLLIEFFELYGRHFNYLKTGIRIKDGGSYVAKDEVQKNMLDGYRPSMLYIEDPLQPGNDVGRS SYGAMQVKQAFDYAYVVLSHAVSPIAKYYPNNETESILGRIIRVTDEVATYRDWISKQWGLKNRPEPSCNGKIFSLVQCRPLLPHSPALV -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for NKD1-PAPD5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | NKD1 | chr16:50583466 | chr16:50248131 | ENST00000268459 | + | 3 | 10 | 125_190 | 64.0 | 471.0 | DVL1%2C DVL2 and DVL3 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for NKD1-PAPD5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for NKD1-PAPD5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies