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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NKTR-ULK4 (FusionGDB2 ID:59288)

Fusion Gene Summary for NKTR-ULK4

check button Fusion gene summary
Fusion gene informationFusion gene name: NKTR-ULK4
Fusion gene ID: 59288
HgeneTgene
Gene symbol

NKTR

ULK4

Gene ID

4820

54986

Gene namenatural killer cell triggering receptorunc-51 like kinase 4
Synonymsp104FAM7C1|REC01035
Cytomap

3p22.1

3p22.1

Type of geneprotein-codingprotein-coding
DescriptionNK-tumor recognition proteinNK-TR proteinPPIasenatural killer triggering receptornatural killer-tumor recognition sequencenatural-killer cells cyclophilin-related proteinpeptidyl-prolyl cis-trans isomerase NKTRrotamaseserine/threonine-protein kinase ULK4
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000460910, ENST00000232978, 
ENST00000442970, 		ENST00000301831, 
ENST00000420927, ENST00000414606, 
ENST00000489118, 
Fusion gene scores* DoF score8 X 6 X 6=28814 X 21 X 5=1470
# samples 1018
** MAII scorelog2(10/288*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1470*10)=-3.02974734339405
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NKTR [Title/Abstract] AND ULK4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNKTR(42642556)-ULK4(41705190), # samples:1
NKTR(42642556)-ULK4(41977432), # samples:1
NKTR(42661859)-ULK4(41311034), # samples:1
Anticipated loss of major functional domain due to fusion event.NKTR-ULK4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NKTR-ULK4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
NKTR-ULK4 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNKTR

GO:0000413

protein peptidyl-prolyl isomerization

20676357


check buttonFusion gene breakpoints across NKTR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ULK4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315469NKTRchr3

42642556

+ULK4chr3

41977432

-
ChimerDB4Non-CancerSPNT_228NKTRchr3

42642556

+ULK4chr3

41705190

-
ChiTaRS5.0N/AFN154165NKTRchr3

42661859

-ULK4chr3

41311034

+


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Fusion Gene ORF analysis for NKTR-ULK4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000460910ENST00000301831NKTRchr3

42642556

+ULK4chr3

41977432

-
3UTR-3CDSENST00000460910ENST00000301831NKTRchr3

42642556

+ULK4chr3

41705190

-
3UTR-3CDSENST00000460910ENST00000420927NKTRchr3

42642556

+ULK4chr3

41977432

-
3UTR-intronENST00000460910ENST00000414606NKTRchr3

42642556

+ULK4chr3

41977432

-
3UTR-intronENST00000460910ENST00000414606NKTRchr3

42642556

+ULK4chr3

41705190

-
3UTR-intronENST00000460910ENST00000420927NKTRchr3

42642556

+ULK4chr3

41705190

-
3UTR-intronENST00000460910ENST00000489118NKTRchr3

42642556

+ULK4chr3

41977432

-
3UTR-intronENST00000460910ENST00000489118NKTRchr3

42642556

+ULK4chr3

41705190

-
5CDS-intronENST00000232978ENST00000414606NKTRchr3

42642556

+ULK4chr3

41977432

-
5CDS-intronENST00000232978ENST00000414606NKTRchr3

42642556

+ULK4chr3

41705190

-
5CDS-intronENST00000232978ENST00000420927NKTRchr3

42642556

+ULK4chr3

41705190

-
5CDS-intronENST00000232978ENST00000489118NKTRchr3

42642556

+ULK4chr3

41977432

-
5CDS-intronENST00000232978ENST00000489118NKTRchr3

42642556

+ULK4chr3

41705190

-
5CDS-intronENST00000442970ENST00000414606NKTRchr3

42642556

+ULK4chr3

41977432

-
5CDS-intronENST00000442970ENST00000414606NKTRchr3

42642556

+ULK4chr3

41705190

-
5CDS-intronENST00000442970ENST00000420927NKTRchr3

42642556

+ULK4chr3

41705190

-
5CDS-intronENST00000442970ENST00000489118NKTRchr3

42642556

+ULK4chr3

41977432

-
5CDS-intronENST00000442970ENST00000489118NKTRchr3

42642556

+ULK4chr3

41705190

-
Frame-shiftENST00000232978ENST00000301831NKTRchr3

42642556

+ULK4chr3

41705190

-
Frame-shiftENST00000442970ENST00000301831NKTRchr3

42642556

+ULK4chr3

41705190

-
In-frameENST00000232978ENST00000301831NKTRchr3

42642556

+ULK4chr3

41977432

-
In-frameENST00000232978ENST00000420927NKTRchr3

42642556

+ULK4chr3

41977432

-
In-frameENST00000442970ENST00000301831NKTRchr3

42642556

+ULK4chr3

41977432

-
In-frameENST00000442970ENST00000420927NKTRchr3

42642556

+ULK4chr3

41977432

-
intron-intronENST00000232978ENST00000301831NKTRchr3

42661859

-ULK4chr3

41311034

+
intron-intronENST00000232978ENST00000414606NKTRchr3

42661859

-ULK4chr3

41311034

+
intron-intronENST00000232978ENST00000420927NKTRchr3

42661859

-ULK4chr3

41311034

+
intron-intronENST00000232978ENST00000489118NKTRchr3

42661859

-ULK4chr3

41311034

+
intron-intronENST00000442970ENST00000301831NKTRchr3

42661859

-ULK4chr3

41311034

+
intron-intronENST00000442970ENST00000414606NKTRchr3

42661859

-ULK4chr3

41311034

+
intron-intronENST00000442970ENST00000420927NKTRchr3

42661859

-ULK4chr3

41311034

+
intron-intronENST00000442970ENST00000489118NKTRchr3

42661859

-ULK4chr3

41311034

+
intron-intronENST00000460910ENST00000301831NKTRchr3

42661859

-ULK4chr3

41311034

+
intron-intronENST00000460910ENST00000414606NKTRchr3

42661859

-ULK4chr3

41311034

+
intron-intronENST00000460910ENST00000420927NKTRchr3

42661859

-ULK4chr3

41311034

+
intron-intronENST00000460910ENST00000489118NKTRchr3

42661859

-ULK4chr3

41311034

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000232978NKTRchr342642556+ENST00000301831ULK4chr341977432-41582464738351262
ENST00000232978NKTRchr342642556+ENST00000420927ULK4chr341977432-1795246471750567
ENST00000442970NKTRchr342642556+ENST00000301831ULK4chr341977432-40291175937061215
ENST00000442970NKTRchr342642556+ENST00000420927ULK4chr341977432-1666117591621520

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000232978ENST00000301831NKTRchr342642556+ULK4chr341977432-0.0010663650.9989336
ENST00000232978ENST00000420927NKTRchr342642556+ULK4chr341977432-0.0121416110.9878584
ENST00000442970ENST00000301831NKTRchr342642556+ULK4chr341977432-0.0010024110.9989976
ENST00000442970ENST00000420927NKTRchr342642556+ULK4chr341977432-0.0138575480.98614246

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Fusion Genomic Features for NKTR-ULK4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NKTR-ULK4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:42642556/chr3:41705190)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneULK4chr3:42642556chr3:41977432ENST000003018312371147_1150791276.0Compositional biasNote=Poly-Leu
TgeneULK4chr3:42642556chr3:41977432ENST000004209272181147_115079581.0Compositional biasNote=Poly-Leu
TgeneULK4chr3:42642556chr3:41977432ENST000003018312371025_1063791276.0RepeatNote=HEAT 3
TgeneULK4chr3:42642556chr3:41977432ENST000003018312371151_1189791276.0RepeatNote=HEAT 4
TgeneULK4chr3:42642556chr3:41977432ENST000003018312371213_1253791276.0RepeatNote=HEAT 5
TgeneULK4chr3:42642556chr3:41977432ENST00000301831237842_880791276.0RepeatNote=HEAT 1
TgeneULK4chr3:42642556chr3:41977432ENST00000301831237926_964791276.0RepeatNote=HEAT 2
TgeneULK4chr3:42642556chr3:41977432ENST000004209272181025_106379581.0RepeatNote=HEAT 3
TgeneULK4chr3:42642556chr3:41977432ENST000004209272181151_118979581.0RepeatNote=HEAT 4
TgeneULK4chr3:42642556chr3:41977432ENST000004209272181213_125379581.0RepeatNote=HEAT 5
TgeneULK4chr3:42642556chr3:41977432ENST00000420927218842_88079581.0RepeatNote=HEAT 1
TgeneULK4chr3:42642556chr3:41977432ENST00000420927218926_96479581.0RepeatNote=HEAT 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNKTRchr3:42642556chr3:41977432ENST00000232978+217194_244191463.0Compositional biasNote=Arg/Ser-rich
HgeneNKTRchr3:42642556chr3:41977432ENST00000232978+217219_240191463.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneNKTRchr3:42642556chr3:41977432ENST00000232978+217421_457191463.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneNKTRchr3:42642556chr3:41977432ENST00000232978+217466_574191463.0Compositional biasNote=Arg/Ser-rich
HgeneNKTRchr3:42642556chr3:41977432ENST00000232978+217664_814191463.0Compositional biasNote=Arg/Ser-rich
HgeneNKTRchr3:42642556chr3:41977432ENST00000232978+217970_1010191463.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneNKTRchr3:42642556chr3:41977432ENST00000232978+21710_175191463.0DomainPPIase cyclophilin-type
HgeneNKTRchr3:42642556chr3:41977432ENST00000232978+2171311_1348191463.0RegionNote=Arg/Ser tandem repeat-rich
TgeneULK4chr3:42642556chr3:41977432ENST000003018312374_280791276.0DomainProtein kinase
TgeneULK4chr3:42642556chr3:41977432ENST000004209272184_28079581.0DomainProtein kinase


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Fusion Gene Sequence for NKTR-ULK4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>59288_59288_1_NKTR-ULK4_NKTR_chr3_42642556_ENST00000232978_ULK4_chr3_41977432_ENST00000301831_length(transcript)=4158nt_BP=246nt
GTACTCTCGCGGTATTTGTCCCGACTCTCGCGGGGTTTAGCGTGGCATTGGGAGGCCCGGCCTGGGGGAGGAGACGGCGTTCCGTTAGCG
GCGTTGGGGTTTGGCTGCAGTGGCAGTGCTTTCTCTTCTGCTCACGGGGACCCGCTCAGGCTGGAGGCCAGCCAGCTCTTGCCGCCACCT
CGGTCGCGATGGGGGCGCAGGACCGGCCGCAGTGCCACTTCGACATCGAGATCAACCGGGAGCCGGGTGGTTCCTTAAAAACAGTTATTG
CTCAAGATGAAAACCTCCCAGAAGATGTTGTGAGAGAATTTGGAATTGACCTGATTAGTGGATTACATCATCTTCATAAACTTGGCATTC
TCTTTTGTGACATTTCTCCTAGGAAGATACTCTTGGAAGGGCCTGGCACACTGAAGTTTAGCAACTTTTGCTTGGCAAAAGTGGAAGGTG
AAAATTTGGAAGAGTTCTTTGCTTTGGTGGCAGCAGAGGAAGGAGGAGGTGATAATGGGGAAAATGTCCTGAAGAAAAGCATGAAAAGTA
GAGTCAAAGGATCTCCTGTATATACAGCACCAGAAGTTGTGAGGGGTGCTGACTTTTCCATCTCCAGTGACCTCTGGTCTTTGGGCTGTC
TGCTTTATGAAATGTTTTCAGGAAAACCTCCATTCTTCTCAGAAAGTATTTCAGAATTAACTGAAAAGATCTTATGTGAAGATCCTTTGC
CACCTATTCCGAAAGATTCTTCTCGTCCTAAAGCTTCTTCAGATTTTATTAATTTGCTTGATGGGTTACTTCAAAGAGATCCTCAGAAAA
GATTGACTTGGACAAGGCTACTGCAGCATTCATTTTGGAAGAAAGCTTTTGCTGGAGCAGATCAGGAATCAAGCGTCGAAGATCTCAGTC
TCAGCAGAAACACTATGGAGTGTTCTGGGCCACAAGATTCCAAGGAGCTTTTGCAGAACTCTCAGAGTAGACAAGCAAAAGGGCACAAGA
GTGGTCAACCACTAGGTCACTCTTTCAGACTAGAAAATCCAACTGAGTTTCGGCCTAAGAGTACTCTTGAGGGTCAATTGAATGAATCCA
TGTTTCTTCTCAGTTCTCGTCCTACTCCCAGAACTAGCACTGCAGTGGAAGTAAGTCCTGGTGAGGATATGACTCACTGTTCACCACAGA
AGACTTCTCCTCTGACCAAGATTACAAGTGGACACCTGAGTCAGCAGGACCTGGAATCCCAGATGAGAGAGCTTATCTACACGGACTCAG
ATCTTGTTGTCACCCCCATTATCGACAATCCAAAGATAATGAAACAGCCACCAGTTAAATTTGATGCAAAAATATTGCATCTACCAACAT
ATTCAGTGGATAAGTTATTATTTCTGAAAGATCAAGATTGGAATGACTTTTTGCAACAAGTGTGCTCGCAGATCGACTCCACTGAGAAGA
GCATGGGGGCCTCCCGAGCCAAGCTGAATCTCCTTTGCTATTTGTGCGTGGTGGCTGGTCACCAGGAGGTGGCCACCAGGCTCCTCCATT
CCCCCCTGTTCCAATTGCTAATCCAGCATTTGCGGATAGCTCCAAACTGGGATATACGGGCCAAGGTTGCTCACGTAATTGGTTTACTGG
CTTCGCACACAGCTGAGCTCCAGGAAAATACACCTGTTGTTGAGGCAATTGTTCTCTTAACTGAATTAATTAGGGAAAACTTCAGGAACA
GCAAATTAAAACAGTGCCTTTTACCAACCCTTGGGGAGCTGATCTATCTTGTAGCCACCCAGGAAGAAAAAAAAAAGAACCCTAGAGAGT
GCTGGGCTGTTCCCTTGGCTGCATACACAGTGCTAATGAGGTGCCTTCGGGAAGGGGAAGAGCGTGTTGTGAATCACATGGCAGCAAAAA
TTATTGAAAATGTCTGTACCACCTTTTCTGCTCAGTCCCAGGGCTTTATTACAGGAGAAATAGGACCCATTTTGTGGTACCTATTCAGAC
ACTCCACTGCTGATTCTCTTAGGATAACAGCAGTATCGGCCTTGTGTAGAATCACTCGCCATTCTCCTACTGCCTTCCAGAATGTTATTG
AAAAGGTGGGACTGAACTCAGTAATAAACTCCCTGGCCTCTGCCATCTGCAAAGTTCAGCAGTACATGTTGACCTTATTCGCTGCCATGT
TGTCCTGTGGGATTCATCTTCAAAGACTAATCCAAGAAAAGGGTTTTGTCTCCACAATTATCCGTTTACTTGACAGCCCCTCAACATGCA
TTAGAGCAAAAGCCTTCCTGGTTCTTCTATATATTTTGATTTATAACCGTGAGATGTTGCTGCTCAGTTGCCAAGCAAGACTGGTGATGT
ACATCGAGAGAGACAGCAGAAAGACCACTCCAGGCAAGGAGCAGCAAAGTGGCAATGAATACCTGTCCAAATGCCTGGATCTTCTCATCT
GTCACATTGTGCAGGAGCTGCCACGAATCCTGGGTGACATTCTTAACTCCTTGGCTAATGTTTCTGGACGTAAACACCCATCAACAGTTC
AAGTGAAACAGCTGAAGTTGTGTCTCCCCCTGATGCCTGTAGTGCTTCACCTCGTAACTTCACAGGTATTTCGACCTCAAGTTGTGACAG
AAGAGTTTCTTTTCAGCTATGGAACTATTCTTAGTCATATTAAATCTGTAGACTCAGGAGAAACGAACATAGATGGAGCCATAGGACTGA
CAGCATCAGAAGAATTTATCAAGATCACATTGTCAGCTTTTGAAGCAATAATACAGTATCCTATTTTATTGAAAGACTATCGCTCCACGG
TTGTTGACTATATACTGCCACCCTTGGTGTCCTTGGTTCAAAGCCAAAATGTGGAGTGGAGACTCTTTAGCTTGCGGTTGCTCTCAGAAA
CCACATCTCTACTCGTGAACCAGGAGTTTGGGGATGGCAAGGAGAAGGCCAGTGTTGATTCTGACAGCAATCTTCTGGCTCTCATTCGAG
ATGTCTTACTTCCCCAGTATGAGCACATTCTTTTAGAACCTGACCCAGTACCAGCATATGCTCTGAAACTGCTAGTCGCGATGACTGAAC
ACAACCCAACTTTCACAAGACTTGTGGAAGAAAGCAAACTGATCCCACTCATTTTTGAAGTAACTCTGGAACATCAGGAGAGCATTCTGG
GTAATACCATGCAAAGTGTGATTGCATTACTCAGCAATCTAGTTGCCTGCAAAGATTCGAATATGGAACTACTTTATGAACAAGGACTTG
TCAGTCACATCTGTAACCTGCTCACTGAAACTGCCACACTGTGCTTGGATGTGGACAATAAAAACAACAATGAGATGGCAGCTCCACTGC
TCTTTTCCCTGCTTGATATTTTGCACAGCATGCTGACCTATACCTCCGGTATTGTACGGCTGGCTTTGCAGGCCCAGAAGTCTGGCTCAG
GAGAGGACCCTCAGGCTGCAGAAGACCTGCTGCTGCTCAACAGACCTCTGACAGACCTGATTAGCCTGCTCATTCCACTGCTTCCTAATG
AAGATCCTGAGATTTTTGATGTTTCATCCAAGTGCCTGTCTATACTGGTTCAGCTGTATGGAGGGGAAAACCCGGACAGCCTCTCTCCTG
AAAATGTGGAAATTTTTGCTCATTTACTGACATCCAAGGAGGACCCAAAGGAGCAGAAGCTTCTGTTAAGGATTCTCAGAAGAATGATCA
CCTCCAATGAGAAGCACTTGGAGAGCCTCAAGAATGCAGGCAGCCTCCTGCGGGCTCTGGAGCGGCTGGCCCCTGGGAGTGGTTCATTTG
CCGACAGTGCGGTGGCTCCCTTGGCCCTGGAAATCCTCCAAGCCGTTGGGCACTAGGCAAGAAGGTGCTTAGCACAAGCCCGCCCTGTGG
CCCCAGCCCTCGGATGCATAAGCAAGGTCAGCTCCCAGACACCTTTGCCACATCCCCTCACAGCTGTCTTTGGACCTAATAAAGTCAGCT
TAACCCAGAACCTGGTGGCCCAAGTGCTCACTAACCCCAGGGCCTAGAAAACTGACTCAGAATGGACTTCCTTGGTTCCTGTGGAATGCA
TCTGGGAAGCCCAGGTTTGTTAGCTGTTCTCAGAAATGTTCTTTCCCTCTCTGTGTGGGCCAGGTGGGCTAAGGTTAGCACTGCCTGTGG

>59288_59288_1_NKTR-ULK4_NKTR_chr3_42642556_ENST00000232978_ULK4_chr3_41977432_ENST00000301831_length(amino acids)=1262AA_BP=66
MGGPAWGRRRRSVSGVGVWLQWQCFLFCSRGPAQAGGQPALAATSVAMGAQDRPQCHFDIEINREPGGSLKTVIAQDENLPEDVVREFGI
DLISGLHHLHKLGILFCDISPRKILLEGPGTLKFSNFCLAKVEGENLEEFFALVAAEEGGGDNGENVLKKSMKSRVKGSPVYTAPEVVRG
ADFSISSDLWSLGCLLYEMFSGKPPFFSESISELTEKILCEDPLPPIPKDSSRPKASSDFINLLDGLLQRDPQKRLTWTRLLQHSFWKKA
FAGADQESSVEDLSLSRNTMECSGPQDSKELLQNSQSRQAKGHKSGQPLGHSFRLENPTEFRPKSTLEGQLNESMFLLSSRPTPRTSTAV
EVSPGEDMTHCSPQKTSPLTKITSGHLSQQDLESQMRELIYTDSDLVVTPIIDNPKIMKQPPVKFDAKILHLPTYSVDKLLFLKDQDWND
FLQQVCSQIDSTEKSMGASRAKLNLLCYLCVVAGHQEVATRLLHSPLFQLLIQHLRIAPNWDIRAKVAHVIGLLASHTAELQENTPVVEA
IVLLTELIRENFRNSKLKQCLLPTLGELIYLVATQEEKKKNPRECWAVPLAAYTVLMRCLREGEERVVNHMAAKIIENVCTTFSAQSQGF
ITGEIGPILWYLFRHSTADSLRITAVSALCRITRHSPTAFQNVIEKVGLNSVINSLASAICKVQQYMLTLFAAMLSCGIHLQRLIQEKGF
VSTIIRLLDSPSTCIRAKAFLVLLYILIYNREMLLLSCQARLVMYIERDSRKTTPGKEQQSGNEYLSKCLDLLICHIVQELPRILGDILN
SLANVSGRKHPSTVQVKQLKLCLPLMPVVLHLVTSQVFRPQVVTEEFLFSYGTILSHIKSVDSGETNIDGAIGLTASEEFIKITLSAFEA
IIQYPILLKDYRSTVVDYILPPLVSLVQSQNVEWRLFSLRLLSETTSLLVNQEFGDGKEKASVDSDSNLLALIRDVLLPQYEHILLEPDP
VPAYALKLLVAMTEHNPTFTRLVEESKLIPLIFEVTLEHQESILGNTMQSVIALLSNLVACKDSNMELLYEQGLVSHICNLLTETATLCL
DVDNKNNNEMAAPLLFSLLDILHSMLTYTSGIVRLALQAQKSGSGEDPQAAEDLLLLNRPLTDLISLLIPLLPNEDPEIFDVSSKCLSIL
VQLYGGENPDSLSPENVEIFAHLLTSKEDPKEQKLLLRILRRMITSNEKHLESLKNAGSLLRALERLAPGSGSFADSAVAPLALEILQAV

--------------------------------------------------------------
>59288_59288_2_NKTR-ULK4_NKTR_chr3_42642556_ENST00000232978_ULK4_chr3_41977432_ENST00000420927_length(transcript)=1795nt_BP=246nt
GTACTCTCGCGGTATTTGTCCCGACTCTCGCGGGGTTTAGCGTGGCATTGGGAGGCCCGGCCTGGGGGAGGAGACGGCGTTCCGTTAGCG
GCGTTGGGGTTTGGCTGCAGTGGCAGTGCTTTCTCTTCTGCTCACGGGGACCCGCTCAGGCTGGAGGCCAGCCAGCTCTTGCCGCCACCT
CGGTCGCGATGGGGGCGCAGGACCGGCCGCAGTGCCACTTCGACATCGAGATCAACCGGGAGCCGGGTGGTTCCTTAAAAACAGTTATTG
CTCAAGATGAAAACCTCCCAGAAGATGTTGTGAGAGAATTTGGAATTGACCTGATTAGTGGATTACATCATCTTCATAAACTTGGCATTC
TCTTTTGTGACATTTCTCCTAGGAAGATACTCTTGGAAGGGCCTGGCACACTGAAGTTTAGCAACTTTTGCTTGGCAAAAGTGGAAGGTG
AAAATTTGGAAGAGTTCTTTGCTTTGGTGGCAGCAGAGGAAGGAGGAGGTGATAATGGGGAAAATGTCCTGAAGAAAAGCATGAAAAGTA
GAGTCAAAGGATCTCCTGTATATACAGCACCAGAAGTTGTGAGGGGTGCTGACTTTTCCATCTCCAGTGACCTCTGGTCTTTGGGCTGTC
TGCTTTATGAAATGTTTTCAGGAAAACCTCCATTCTTCTCAGAAAGTATTTCAGAATTAACTGAAAAGATCTTATGTGAAGATCCTTTGC
CACCTATTCCGAAAGATTCTTCTCGTCCTAAAGCTTCTTCAGATTTTATTAATTTGCTTGATGGGTTACTTCAAAGAGATCCTCAGAAAA
GATTGACTTGGACAAGGCTACTGCAGCATTCATTTTGGAAGAAAGCTTTTGCTGGAGCAGATCAGGAATCAAGCGTCGAAGATCTCAGTC
TCAGCAGAAACACTATGGAGTGTTCTGGGCCACAAGATTCCAAGGAGCTTTTGCAGAACTCTCAGAGTAGACAAGCAAAAGGGCACAAGA
GTGGTCAACCACTAGGTCACTCTTTCAGACTAGAAAATCCAACTGAGTTTCGGCCTAAGAGTACTCTTGAGGGTCAATTGAATGAATCCA
TGTTTCTTCTCAGTTCTCGTCCTACTCCCAGAACTAGCACTGCAGTGGAAGTAAGTCCTGGTGAGGATATGACTCACTGTTCACCACAGA
AGACTTCTCCTCTGACCAAGATTACAAGTGGACACCTGAGTCAGCAGGACCTGGAATCCCAGATGAGAGAGCTTATCTACACGGACTCAG
ATCTTGTTGTCACCCCCATTATCGACAATCCAAAGATAATGAAACAGCCACCAGTTAAATTTGATGCAAAAATATTGCATCTACCAACAT
ATTCAGTGGATAAGTTATTATTTCTGAAAGATCAAGATTGGAATGACTTTTTGCAACAAGTGTGCTCGCAGATCGACTCCACTGAGAAGA
GCATGGGGGCCTCCCGAGCCAAGCTGAATCTCCTTTGCTATTTGTGCGTGGTGGCTGGTCACCAGGAGGTGGCCACCAGGCTCCTCCATT
CCCCCCTGTTCCAATTGCTAATCCAGCATTTGCGGATAGCTCCAAACTGGGATATACGGGCCAAGGTTGCTCACGTAATTGGTTTACTGG
CTTCGCACACAGCTGAGCTCCAGGAAAATACACCTGTTGTTGAGACTACAAGCTCCATTGGAATCGGGATTTTGAACTGTCTTGTTCAAC

>59288_59288_2_NKTR-ULK4_NKTR_chr3_42642556_ENST00000232978_ULK4_chr3_41977432_ENST00000420927_length(amino acids)=567AA_BP=66
MGGPAWGRRRRSVSGVGVWLQWQCFLFCSRGPAQAGGQPALAATSVAMGAQDRPQCHFDIEINREPGGSLKTVIAQDENLPEDVVREFGI
DLISGLHHLHKLGILFCDISPRKILLEGPGTLKFSNFCLAKVEGENLEEFFALVAAEEGGGDNGENVLKKSMKSRVKGSPVYTAPEVVRG
ADFSISSDLWSLGCLLYEMFSGKPPFFSESISELTEKILCEDPLPPIPKDSSRPKASSDFINLLDGLLQRDPQKRLTWTRLLQHSFWKKA
FAGADQESSVEDLSLSRNTMECSGPQDSKELLQNSQSRQAKGHKSGQPLGHSFRLENPTEFRPKSTLEGQLNESMFLLSSRPTPRTSTAV
EVSPGEDMTHCSPQKTSPLTKITSGHLSQQDLESQMRELIYTDSDLVVTPIIDNPKIMKQPPVKFDAKILHLPTYSVDKLLFLKDQDWND
FLQQVCSQIDSTEKSMGASRAKLNLLCYLCVVAGHQEVATRLLHSPLFQLLIQHLRIAPNWDIRAKVAHVIGLLASHTAELQENTPVVET

--------------------------------------------------------------
>59288_59288_3_NKTR-ULK4_NKTR_chr3_42642556_ENST00000442970_ULK4_chr3_41977432_ENST00000301831_length(transcript)=4029nt_BP=117nt
GCTCACGGGGACCCGCTCAGGCTGGAGGCCAGCCAGCTCTTGCCGCCACCTCGGTCGCGATGGGGGCGCAGGACCGGCCGCAGTGCCACT
TCGACATCGAGATCAACCGGGAGCCGGGTGGTTCCTTAAAAACAGTTATTGCTCAAGATGAAAACCTCCCAGAAGATGTTGTGAGAGAAT
TTGGAATTGACCTGATTAGTGGATTACATCATCTTCATAAACTTGGCATTCTCTTTTGTGACATTTCTCCTAGGAAGATACTCTTGGAAG
GGCCTGGCACACTGAAGTTTAGCAACTTTTGCTTGGCAAAAGTGGAAGGTGAAAATTTGGAAGAGTTCTTTGCTTTGGTGGCAGCAGAGG
AAGGAGGAGGTGATAATGGGGAAAATGTCCTGAAGAAAAGCATGAAAAGTAGAGTCAAAGGATCTCCTGTATATACAGCACCAGAAGTTG
TGAGGGGTGCTGACTTTTCCATCTCCAGTGACCTCTGGTCTTTGGGCTGTCTGCTTTATGAAATGTTTTCAGGAAAACCTCCATTCTTCT
CAGAAAGTATTTCAGAATTAACTGAAAAGATCTTATGTGAAGATCCTTTGCCACCTATTCCGAAAGATTCTTCTCGTCCTAAAGCTTCTT
CAGATTTTATTAATTTGCTTGATGGGTTACTTCAAAGAGATCCTCAGAAAAGATTGACTTGGACAAGGCTACTGCAGCATTCATTTTGGA
AGAAAGCTTTTGCTGGAGCAGATCAGGAATCAAGCGTCGAAGATCTCAGTCTCAGCAGAAACACTATGGAGTGTTCTGGGCCACAAGATT
CCAAGGAGCTTTTGCAGAACTCTCAGAGTAGACAAGCAAAAGGGCACAAGAGTGGTCAACCACTAGGTCACTCTTTCAGACTAGAAAATC
CAACTGAGTTTCGGCCTAAGAGTACTCTTGAGGGTCAATTGAATGAATCCATGTTTCTTCTCAGTTCTCGTCCTACTCCCAGAACTAGCA
CTGCAGTGGAAGTAAGTCCTGGTGAGGATATGACTCACTGTTCACCACAGAAGACTTCTCCTCTGACCAAGATTACAAGTGGACACCTGA
GTCAGCAGGACCTGGAATCCCAGATGAGAGAGCTTATCTACACGGACTCAGATCTTGTTGTCACCCCCATTATCGACAATCCAAAGATAA
TGAAACAGCCACCAGTTAAATTTGATGCAAAAATATTGCATCTACCAACATATTCAGTGGATAAGTTATTATTTCTGAAAGATCAAGATT
GGAATGACTTTTTGCAACAAGTGTGCTCGCAGATCGACTCCACTGAGAAGAGCATGGGGGCCTCCCGAGCCAAGCTGAATCTCCTTTGCT
ATTTGTGCGTGGTGGCTGGTCACCAGGAGGTGGCCACCAGGCTCCTCCATTCCCCCCTGTTCCAATTGCTAATCCAGCATTTGCGGATAG
CTCCAAACTGGGATATACGGGCCAAGGTTGCTCACGTAATTGGTTTACTGGCTTCGCACACAGCTGAGCTCCAGGAAAATACACCTGTTG
TTGAGGCAATTGTTCTCTTAACTGAATTAATTAGGGAAAACTTCAGGAACAGCAAATTAAAACAGTGCCTTTTACCAACCCTTGGGGAGC
TGATCTATCTTGTAGCCACCCAGGAAGAAAAAAAAAAGAACCCTAGAGAGTGCTGGGCTGTTCCCTTGGCTGCATACACAGTGCTAATGA
GGTGCCTTCGGGAAGGGGAAGAGCGTGTTGTGAATCACATGGCAGCAAAAATTATTGAAAATGTCTGTACCACCTTTTCTGCTCAGTCCC
AGGGCTTTATTACAGGAGAAATAGGACCCATTTTGTGGTACCTATTCAGACACTCCACTGCTGATTCTCTTAGGATAACAGCAGTATCGG
CCTTGTGTAGAATCACTCGCCATTCTCCTACTGCCTTCCAGAATGTTATTGAAAAGGTGGGACTGAACTCAGTAATAAACTCCCTGGCCT
CTGCCATCTGCAAAGTTCAGCAGTACATGTTGACCTTATTCGCTGCCATGTTGTCCTGTGGGATTCATCTTCAAAGACTAATCCAAGAAA
AGGGTTTTGTCTCCACAATTATCCGTTTACTTGACAGCCCCTCAACATGCATTAGAGCAAAAGCCTTCCTGGTTCTTCTATATATTTTGA
TTTATAACCGTGAGATGTTGCTGCTCAGTTGCCAAGCAAGACTGGTGATGTACATCGAGAGAGACAGCAGAAAGACCACTCCAGGCAAGG
AGCAGCAAAGTGGCAATGAATACCTGTCCAAATGCCTGGATCTTCTCATCTGTCACATTGTGCAGGAGCTGCCACGAATCCTGGGTGACA
TTCTTAACTCCTTGGCTAATGTTTCTGGACGTAAACACCCATCAACAGTTCAAGTGAAACAGCTGAAGTTGTGTCTCCCCCTGATGCCTG
TAGTGCTTCACCTCGTAACTTCACAGGTATTTCGACCTCAAGTTGTGACAGAAGAGTTTCTTTTCAGCTATGGAACTATTCTTAGTCATA
TTAAATCTGTAGACTCAGGAGAAACGAACATAGATGGAGCCATAGGACTGACAGCATCAGAAGAATTTATCAAGATCACATTGTCAGCTT
TTGAAGCAATAATACAGTATCCTATTTTATTGAAAGACTATCGCTCCACGGTTGTTGACTATATACTGCCACCCTTGGTGTCCTTGGTTC
AAAGCCAAAATGTGGAGTGGAGACTCTTTAGCTTGCGGTTGCTCTCAGAAACCACATCTCTACTCGTGAACCAGGAGTTTGGGGATGGCA
AGGAGAAGGCCAGTGTTGATTCTGACAGCAATCTTCTGGCTCTCATTCGAGATGTCTTACTTCCCCAGTATGAGCACATTCTTTTAGAAC
CTGACCCAGTACCAGCATATGCTCTGAAACTGCTAGTCGCGATGACTGAACACAACCCAACTTTCACAAGACTTGTGGAAGAAAGCAAAC
TGATCCCACTCATTTTTGAAGTAACTCTGGAACATCAGGAGAGCATTCTGGGTAATACCATGCAAAGTGTGATTGCATTACTCAGCAATC
TAGTTGCCTGCAAAGATTCGAATATGGAACTACTTTATGAACAAGGACTTGTCAGTCACATCTGTAACCTGCTCACTGAAACTGCCACAC
TGTGCTTGGATGTGGACAATAAAAACAACAATGAGATGGCAGCTCCACTGCTCTTTTCCCTGCTTGATATTTTGCACAGCATGCTGACCT
ATACCTCCGGTATTGTACGGCTGGCTTTGCAGGCCCAGAAGTCTGGCTCAGGAGAGGACCCTCAGGCTGCAGAAGACCTGCTGCTGCTCA
ACAGACCTCTGACAGACCTGATTAGCCTGCTCATTCCACTGCTTCCTAATGAAGATCCTGAGATTTTTGATGTTTCATCCAAGTGCCTGT
CTATACTGGTTCAGCTGTATGGAGGGGAAAACCCGGACAGCCTCTCTCCTGAAAATGTGGAAATTTTTGCTCATTTACTGACATCCAAGG
AGGACCCAAAGGAGCAGAAGCTTCTGTTAAGGATTCTCAGAAGAATGATCACCTCCAATGAGAAGCACTTGGAGAGCCTCAAGAATGCAG
GCAGCCTCCTGCGGGCTCTGGAGCGGCTGGCCCCTGGGAGTGGTTCATTTGCCGACAGTGCGGTGGCTCCCTTGGCCCTGGAAATCCTCC
AAGCCGTTGGGCACTAGGCAAGAAGGTGCTTAGCACAAGCCCGCCCTGTGGCCCCAGCCCTCGGATGCATAAGCAAGGTCAGCTCCCAGA
CACCTTTGCCACATCCCCTCACAGCTGTCTTTGGACCTAATAAAGTCAGCTTAACCCAGAACCTGGTGGCCCAAGTGCTCACTAACCCCA
GGGCCTAGAAAACTGACTCAGAATGGACTTCCTTGGTTCCTGTGGAATGCATCTGGGAAGCCCAGGTTTGTTAGCTGTTCTCAGAAATGT

>59288_59288_3_NKTR-ULK4_NKTR_chr3_42642556_ENST00000442970_ULK4_chr3_41977432_ENST00000301831_length(amino acids)=1215AA_BP=19
MGAQDRPQCHFDIEINREPGGSLKTVIAQDENLPEDVVREFGIDLISGLHHLHKLGILFCDISPRKILLEGPGTLKFSNFCLAKVEGENL
EEFFALVAAEEGGGDNGENVLKKSMKSRVKGSPVYTAPEVVRGADFSISSDLWSLGCLLYEMFSGKPPFFSESISELTEKILCEDPLPPI
PKDSSRPKASSDFINLLDGLLQRDPQKRLTWTRLLQHSFWKKAFAGADQESSVEDLSLSRNTMECSGPQDSKELLQNSQSRQAKGHKSGQ
PLGHSFRLENPTEFRPKSTLEGQLNESMFLLSSRPTPRTSTAVEVSPGEDMTHCSPQKTSPLTKITSGHLSQQDLESQMRELIYTDSDLV
VTPIIDNPKIMKQPPVKFDAKILHLPTYSVDKLLFLKDQDWNDFLQQVCSQIDSTEKSMGASRAKLNLLCYLCVVAGHQEVATRLLHSPL
FQLLIQHLRIAPNWDIRAKVAHVIGLLASHTAELQENTPVVEAIVLLTELIRENFRNSKLKQCLLPTLGELIYLVATQEEKKKNPRECWA
VPLAAYTVLMRCLREGEERVVNHMAAKIIENVCTTFSAQSQGFITGEIGPILWYLFRHSTADSLRITAVSALCRITRHSPTAFQNVIEKV
GLNSVINSLASAICKVQQYMLTLFAAMLSCGIHLQRLIQEKGFVSTIIRLLDSPSTCIRAKAFLVLLYILIYNREMLLLSCQARLVMYIE
RDSRKTTPGKEQQSGNEYLSKCLDLLICHIVQELPRILGDILNSLANVSGRKHPSTVQVKQLKLCLPLMPVVLHLVTSQVFRPQVVTEEF
LFSYGTILSHIKSVDSGETNIDGAIGLTASEEFIKITLSAFEAIIQYPILLKDYRSTVVDYILPPLVSLVQSQNVEWRLFSLRLLSETTS
LLVNQEFGDGKEKASVDSDSNLLALIRDVLLPQYEHILLEPDPVPAYALKLLVAMTEHNPTFTRLVEESKLIPLIFEVTLEHQESILGNT
MQSVIALLSNLVACKDSNMELLYEQGLVSHICNLLTETATLCLDVDNKNNNEMAAPLLFSLLDILHSMLTYTSGIVRLALQAQKSGSGED
PQAAEDLLLLNRPLTDLISLLIPLLPNEDPEIFDVSSKCLSILVQLYGGENPDSLSPENVEIFAHLLTSKEDPKEQKLLLRILRRMITSN

--------------------------------------------------------------
>59288_59288_4_NKTR-ULK4_NKTR_chr3_42642556_ENST00000442970_ULK4_chr3_41977432_ENST00000420927_length(transcript)=1666nt_BP=117nt
GCTCACGGGGACCCGCTCAGGCTGGAGGCCAGCCAGCTCTTGCCGCCACCTCGGTCGCGATGGGGGCGCAGGACCGGCCGCAGTGCCACT
TCGACATCGAGATCAACCGGGAGCCGGGTGGTTCCTTAAAAACAGTTATTGCTCAAGATGAAAACCTCCCAGAAGATGTTGTGAGAGAAT
TTGGAATTGACCTGATTAGTGGATTACATCATCTTCATAAACTTGGCATTCTCTTTTGTGACATTTCTCCTAGGAAGATACTCTTGGAAG
GGCCTGGCACACTGAAGTTTAGCAACTTTTGCTTGGCAAAAGTGGAAGGTGAAAATTTGGAAGAGTTCTTTGCTTTGGTGGCAGCAGAGG
AAGGAGGAGGTGATAATGGGGAAAATGTCCTGAAGAAAAGCATGAAAAGTAGAGTCAAAGGATCTCCTGTATATACAGCACCAGAAGTTG
TGAGGGGTGCTGACTTTTCCATCTCCAGTGACCTCTGGTCTTTGGGCTGTCTGCTTTATGAAATGTTTTCAGGAAAACCTCCATTCTTCT
CAGAAAGTATTTCAGAATTAACTGAAAAGATCTTATGTGAAGATCCTTTGCCACCTATTCCGAAAGATTCTTCTCGTCCTAAAGCTTCTT
CAGATTTTATTAATTTGCTTGATGGGTTACTTCAAAGAGATCCTCAGAAAAGATTGACTTGGACAAGGCTACTGCAGCATTCATTTTGGA
AGAAAGCTTTTGCTGGAGCAGATCAGGAATCAAGCGTCGAAGATCTCAGTCTCAGCAGAAACACTATGGAGTGTTCTGGGCCACAAGATT
CCAAGGAGCTTTTGCAGAACTCTCAGAGTAGACAAGCAAAAGGGCACAAGAGTGGTCAACCACTAGGTCACTCTTTCAGACTAGAAAATC
CAACTGAGTTTCGGCCTAAGAGTACTCTTGAGGGTCAATTGAATGAATCCATGTTTCTTCTCAGTTCTCGTCCTACTCCCAGAACTAGCA
CTGCAGTGGAAGTAAGTCCTGGTGAGGATATGACTCACTGTTCACCACAGAAGACTTCTCCTCTGACCAAGATTACAAGTGGACACCTGA
GTCAGCAGGACCTGGAATCCCAGATGAGAGAGCTTATCTACACGGACTCAGATCTTGTTGTCACCCCCATTATCGACAATCCAAAGATAA
TGAAACAGCCACCAGTTAAATTTGATGCAAAAATATTGCATCTACCAACATATTCAGTGGATAAGTTATTATTTCTGAAAGATCAAGATT
GGAATGACTTTTTGCAACAAGTGTGCTCGCAGATCGACTCCACTGAGAAGAGCATGGGGGCCTCCCGAGCCAAGCTGAATCTCCTTTGCT
ATTTGTGCGTGGTGGCTGGTCACCAGGAGGTGGCCACCAGGCTCCTCCATTCCCCCCTGTTCCAATTGCTAATCCAGCATTTGCGGATAG
CTCCAAACTGGGATATACGGGCCAAGGTTGCTCACGTAATTGGTTTACTGGCTTCGCACACAGCTGAGCTCCAGGAAAATACACCTGTTG
TTGAGACTACAAGCTCCATTGGAATCGGGATTTTGAACTGTCTTGTTCAACACTCCACTCCAGTGCCTAGACAGTGCCTTGTGTATGTAT

>59288_59288_4_NKTR-ULK4_NKTR_chr3_42642556_ENST00000442970_ULK4_chr3_41977432_ENST00000420927_length(amino acids)=520AA_BP=19
MGAQDRPQCHFDIEINREPGGSLKTVIAQDENLPEDVVREFGIDLISGLHHLHKLGILFCDISPRKILLEGPGTLKFSNFCLAKVEGENL
EEFFALVAAEEGGGDNGENVLKKSMKSRVKGSPVYTAPEVVRGADFSISSDLWSLGCLLYEMFSGKPPFFSESISELTEKILCEDPLPPI
PKDSSRPKASSDFINLLDGLLQRDPQKRLTWTRLLQHSFWKKAFAGADQESSVEDLSLSRNTMECSGPQDSKELLQNSQSRQAKGHKSGQ
PLGHSFRLENPTEFRPKSTLEGQLNESMFLLSSRPTPRTSTAVEVSPGEDMTHCSPQKTSPLTKITSGHLSQQDLESQMRELIYTDSDLV
VTPIIDNPKIMKQPPVKFDAKILHLPTYSVDKLLFLKDQDWNDFLQQVCSQIDSTEKSMGASRAKLNLLCYLCVVAGHQEVATRLLHSPL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NKTR-ULK4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NKTR-ULK4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NKTR-ULK4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource