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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NLK-SLC39A11 (FusionGDB2 ID:59357)

Fusion Gene Summary for NLK-SLC39A11

Fusion gene summary

Fusion gene information	Fusion gene name: NLK-SLC39A11
	Fusion gene ID: 59357
		Hgene	Tgene
	Gene symbol	NLK	SLC39A11
	Gene ID	51701	201266
	Gene name	nemo like kinase	solute carrier family 39 member 11
	Synonyms	-	C17orf26\|ZIP-11\|ZIP11
	Cytomap	17q11.2	17q24.3-q25.1
	Type of gene	protein-coding	protein-coding
	Description	serine/threonine-protein kinase NLK	zinc transporter ZIP11Zrt- and Irt-like protein 11solute carrier family 39 (metal ion transporter), member 11
	Modification date	20200313	20200313
	UniProtAcc	Q9UBE8	.
	Ensembl transtripts involved in fusion gene	ENST00000407008, ENST00000582037, ENST00000583517,	ENST00000579732, ENST00000579988, ENST00000255559, ENST00000542342,
Fusion gene scores	* DoF score	18 X 10 X 9=1620	24 X 14 X 9=3024
	# samples	20	29
	** MAII score	log2(20/1620*10)=-3.01792190799726 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(29/3024*10)=-3.38233333420614 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NLK [Title/Abstract] AND SLC39A11 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NLK(26449758)-SLC39A11(70944014), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NLK	GO:0050821	protein stabilization	25512613

Fusion gene breakpoints across NLK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SLC39A11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	5373N	NLK	chr17	26449758	+	SLC39A11	chr17	70944014	-

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Fusion Gene ORF analysis for NLK-SLC39A11

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000407008	ENST00000579732	NLK	chr17	26449758	+	SLC39A11	chr17	70944014	-
5CDS-intron	ENST00000407008	ENST00000579988	NLK	chr17	26449758	+	SLC39A11	chr17	70944014	-
In-frame	ENST00000407008	ENST00000255559	NLK	chr17	26449758	+	SLC39A11	chr17	70944014	-
In-frame	ENST00000407008	ENST00000542342	NLK	chr17	26449758	+	SLC39A11	chr17	70944014	-
intron-3CDS	ENST00000582037	ENST00000255559	NLK	chr17	26449758	+	SLC39A11	chr17	70944014	-
intron-3CDS	ENST00000582037	ENST00000542342	NLK	chr17	26449758	+	SLC39A11	chr17	70944014	-
intron-3CDS	ENST00000583517	ENST00000255559	NLK	chr17	26449758	+	SLC39A11	chr17	70944014	-
intron-3CDS	ENST00000583517	ENST00000542342	NLK	chr17	26449758	+	SLC39A11	chr17	70944014	-
intron-intron	ENST00000582037	ENST00000579732	NLK	chr17	26449758	+	SLC39A11	chr17	70944014	-
intron-intron	ENST00000582037	ENST00000579988	NLK	chr17	26449758	+	SLC39A11	chr17	70944014	-
intron-intron	ENST00000583517	ENST00000579732	NLK	chr17	26449758	+	SLC39A11	chr17	70944014	-
intron-intron	ENST00000583517	ENST00000579988	NLK	chr17	26449758	+	SLC39A11	chr17	70944014	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000407008

NLK

chr17

26449758

ENST00000255559

SLC39A11

chr17

70944014

3643

1306

718

2007

429

ENST00000407008

NLK

chr17

26449758

ENST00000542342

SLC39A11

chr17

70944014

3663

1306

718

2028

436

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000407008	ENST00000255559	NLK	chr17	26449758	+	SLC39A11	chr17	70944014	-	0.024926806	0.97507316
ENST00000407008	ENST00000542342	NLK	chr17	26449758	+	SLC39A11	chr17	70944014	-	0.035088476	0.9649115

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Fusion Genomic Features for NLK-SLC39A11

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NLK-SLC39A11

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:26449758/chr17:70944014)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NLK Q9UBE8	.
FUNCTION: Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1. Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members. Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner (PubMed:25512613). {ECO:0000250\|UniProtKB:O54949, ECO:0000269\|PubMed:12482967, ECO:0000269\|PubMed:14960582, ECO:0000269\|PubMed:15004007, ECO:0000269\|PubMed:15764709, ECO:0000269\|PubMed:20061393, ECO:0000269\|PubMed:20118921, ECO:0000269\|PubMed:20874444, ECO:0000269\|PubMed:21454679, ECO:0000269\|PubMed:25512613}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NLK

chr17:26449758

chr17:70944014

ENST00000407008

106_111

196

528.0

Compositional bias

Note=Poly-Ala

Hgene

NLK

chr17:26449758

chr17:70944014

ENST00000407008

115_119

196

528.0

Compositional bias

Note=Poly-Ala

Hgene

NLK

chr17:26449758

chr17:70944014

ENST00000407008

22_25

196

528.0

Compositional bias

Note=Poly-Ala

Hgene

NLK

chr17:26449758

chr17:70944014

ENST00000407008

27_34

196

528.0

Compositional bias

Note=Poly-His

Hgene

NLK

chr17:26449758

chr17:70944014

ENST00000407008

42_48

196

528.0

Compositional bias

Note=Poly-His

Hgene

NLK

chr17:26449758

chr17:70944014

ENST00000407008

71_83

196

528.0

Compositional bias

Note=Poly-Ala

Hgene

NLK

chr17:26449758

chr17:70944014

ENST00000407008

144_152

196

528.0

Nucleotide binding

ATP

Tgene

SLC39A11

chr17:26449758

chr17:70944014

ENST00000255559

194_214

102

336.0

Transmembrane

Helical

Tgene

SLC39A11

chr17:26449758

chr17:70944014

ENST00000255559

263_285

102

336.0

Transmembrane

Helical

Tgene

SLC39A11

chr17:26449758

chr17:70944014

ENST00000255559

290_307

102

336.0

Transmembrane

Helical

Tgene

SLC39A11

chr17:26449758

chr17:70944014

ENST00000255559

322_342

102

336.0

Transmembrane

Helical

Tgene

SLC39A11

chr17:26449758

chr17:70944014

ENST00000542342

194_214

102

343.0

Transmembrane

Helical

Tgene

SLC39A11

chr17:26449758

chr17:70944014

ENST00000542342

263_285

102

343.0

Transmembrane

Helical

Tgene

SLC39A11

chr17:26449758

chr17:70944014

ENST00000542342

290_307

102

343.0

Transmembrane

Helical

Tgene

SLC39A11

chr17:26449758

chr17:70944014

ENST00000542342

322_342

102

343.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NLK

chr17:26449758

chr17:70944014

ENST00000407008

138_427

196

528.0

Domain

Protein kinase

Hgene

NLK

chr17:26449758

chr17:70944014

ENST00000407008

298_300

196

528.0

Motif

Note=TQE

Hgene

NLK

chr17:26449758

chr17:70944014

ENST00000407008

428_527

196

528.0

Region

Required for homodimerization and kinase activation and localization to the nucleus

Tgene

SLC39A11

chr17:26449758

chr17:70944014

ENST00000255559

12_32

102

336.0

Transmembrane

Helical

Tgene

SLC39A11

chr17:26449758

chr17:70944014

ENST00000255559

44_64

102

336.0

Transmembrane

Helical

Tgene

SLC39A11

chr17:26449758

chr17:70944014

ENST00000255559

72_92

102

336.0

Transmembrane

Helical

Tgene

SLC39A11

chr17:26449758

chr17:70944014

ENST00000542342

12_32

102

343.0

Transmembrane

Helical

Tgene

SLC39A11

chr17:26449758

chr17:70944014

ENST00000542342

44_64

102

343.0

Transmembrane

Helical

Tgene

SLC39A11

chr17:26449758

chr17:70944014

ENST00000542342

72_92

102

343.0

Transmembrane

Helical

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Fusion Gene Sequence for NLK-SLC39A11

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>59357_59357_1_NLK-SLC39A11_NLK_chr17_26449758_ENST00000407008_SLC39A11_chr17_70944014_ENST00000255559_length(transcript)=3643nt_BP=1306nt
CCCCGGCTCTCTTTCTCCTCTCTGTCCTGCTGTCGCCTCCTCTCCTCACTCCAGCCTCCTTCCCTGGCTTATTCTGCCCAGGAAAGTTTG
GAACCCCCGCCCCCCCTCCCCAATCAGGTCAACCTGACTAGGAGTAGGGGGAGATGTAGGAAGGCCTGAGAGTTCGGGGGGGGGGAAGCT
GGAAGCTGGTTTCCCAGAAAATTTCCCCCCATCTTCTCCATTTAGGGTGGTGGGAATTTTTTTTAATCCTGTTTTTGAGGAGGTGGTAGG
TGTTTAGAAAAGGATGTGGGAATGGAAGGGGTAGATGAGTCAACCCTCTTTCAAGATTCCAAGGGTGGTGTGTTACCTGATCCTTTTCGT
GTGTGGAGTTCAGGGGGTCGGGAGGTTTGGCCTTTATTCCCACATTCAAAGTTGGAACCTCCCCCAAATTAAGAATGGAGTTTTAGTACC
CACTTGTGGCAGGAATCCTGGGGGGAAGGGGTCCTTTTTTCCTTTTTCTTTTCTTTTTTCCCTTTTTTTTCCTTTTGGCAACCCACACCC
TTCCACACACGCTCACCCCAAAATTAAACACCAAGATCCTCTAACTTGTTTGGATTGACTGATGAAGACATAAAGCTCTATGTTTTTTGA
GGTGGAGTGAGTGGTTTTTCTTCATTTTTAAATGGCCAAATGACAGCTTGACCCAGTTTGCTTTCCAATCAAAGGGCATTTATTTTGAAT
GTCTCTTTGTGGCGCAAGAGCCAACGCAAAAATGATGGCGGCTTACAATGGCGGTACATCTGCAGCAGCAGCAGGTCACCACCACCACCA
TCACCACCACCTTCCACACCTCCCTCCTCCTCACCTGCACCACCACCACCACCCTCAACACCATCTTCATCCGGGGTCGGCTGCCGCTGT
ACACCCTGTACAGCAGCACACCTCTTCGGCAGCTGCGGCAGCCGCAGCAGCGGCTGCAGCTGCAGCCATGTTAAACCCTGGGCAACAACA
GCCATATTTCCCATCACCGGCACCGGGGCAGGCTCCTGGACCAGCTGCAGCAGCCCCAGCTCAGGTACAGGCTGCCGCAGCTGCTACAGT
TAAGGCGCACCATCATCAGCACTCGCATCATCCACAGCAGCAGCTGGATATTGAGCCGGATAGACCTATTGGATATGGAGCCTTTGGTGT
TGTCTGGTCAGTAACAGATCCAAGAGATGGAAAGAGAGTAGCGCTCAAAAAGATGCCCAACGTCTTCCAGAATCTGGTCTCTTGCAAAAG
GGTCTTCCGGGAATTGAAGATGTTGTGTTTTTTTAAGCATGATAATGGTGCAGCAGAAGACCCCCAGACGACCCTGGCACTGAACTTCGG
CTCTACGTTGATGAAGAAGAAGTCTGATCCTGAGGGTCCCGCGCTGCTCTTCCCTGAGAGTGAACTTTCCATCCGGATAGACAAGAGTGA
GAATGGTGAGGCATATCAGAGAAAGAAGGCGGCAGCCACTGGCCTTCCAGAGGGTCCTGCTGTCCCTGTGCCTTCTCGAGGGAATCTGGC
ACAGCCCGGCGGCAGCAGCTGGAGGAGGATCGCACTGCTCATCTTGGCCATCACTATACACAACGTTCCAGAGGGTCTCGCTGTTGGAGT
TGGATTTGGGGCTATAGAAAAGACGGCATCTGCTACCTTTGAGAGTGCCAGGAATTTGGCCATTGGAATCGGGATCCAGAATTTCCCCGA
GGGCCTGGCTGTCAGCCTTCCCTTGCGAGGGGCAGGCTTCTCCACCTGGAGAGCTTTCTGGTATGGGCAGCTGAGCGGCATGGTGGAGCC
CCTGGCCGGGGTCTTTGGTGCCTTTGCCGTGGTGCTGGCTGAGCCCATCCTGCCCTACGCTCTGGCCTTTGCTGCCGGTGCCATGGTCTA
CGTGGTCATGGACGACATCATCCCCGAAGCCCAGATCAGTGGTAATGGGAAACTGGCATCCTGGGCCTCCATCCTGGGATTTGTAGTGAT
GATGTCACTGGACGTTGGCCTGGGCTAGGGCTGAGACGCTTCGGACCCCGGGAAAGGCCATACGAAGAAACAGCAGTGGTTGGCTTCTAT
GGGACAACAAGCTTCTTTCTTCACATTAAAACTTTTTTCCTTCCTCTCTTCTTCATCTCATTATCCTGATTGACTCTGATTATAATAGAA
CCATTTTTACTTTGCTTTGAGGGAGATTTTTGATTTAATGGGGAATTTTAAGGTGTCATGGAAATACAGATTCTTTGTTTTGGCCACTGA
ATGGACTCTCTCTTCAGTGGGATTATCAAGGAACTTCAGATCAGGGAAATCTCCACTTCGGGACCTTCTATCTGCCTCCCAACTCCTCAA
GGTCACCTATAGAAGCGAGCTACCAAAAGACGTCTCCTAAGCATTTTGGTGGCCTAGTGACTCAGGGCAGAGTGGCCAGCACACCTCTCA
TCCGCCCCTCCTGCTCCATCACTGCTGAGCCTCTCCCCATCTAGAATGTTGGAACTGGAGCATCATAAAGATAGCAAGCTACCTTCCAAG
GCCGAGCCAGCCCAGAGAGGAGCATGTCTTCCTTTACCTCCCCCTAAGGAGATACTACATGGGAGGGGGACACAGAAAAAGGGAAGGAAA
TTGGCTAGTCTGGCTTTTTTTTTTTTTTTTTTTAAAGGCAAAGATTGACATTATTGAAGGAAAGGGGATGAGGACAACTGTGAACTCACA
GTGAGCCCTGTGGAAAGAAGAGACAGACAGAGTGTGGGTTTGTTCGGAGGCCTCTGCTGTCAATGGATTCCAGGAGCAAGGCCATTTGTC
GCGCTTTCCAAATTTCTTAGGCATTTATTTTGATAAGTTTATAGCCATCATGTTTCTAAGAGACTTGGAGACACCAGCAAACTGCTAGAA
CTCAAACTCTTCAATTACTCAAAGAAGGAGCCATTTCAGTTAACTCAAGTGAATGAAAGAGTTTTGGAATCTGCTGTGGGTCCTTCCCTG
TTGACCATTTGGTAACTTATAATCTGACAAAAACTCTTGAGCTGCAACAGGCCTTGCCAGAGGGCTCAGGATGGGAAAGGAAGAAGGGGA
TAGGAAAAGAAGAGGTAATTTTACATTTCCCCTTTAAAGTAAATTTTAGCCAACTCATCATTCTGAAATGTCCCTATAAAGAATGAGTCG
AACTAGACCAGAAGCCAGCCTACTCCTTCTTACATAGCTTCTCCAACAGGGGTAGCAATGACCTGTCCACTTCAAACACAGATAAGGCCT
GCCATCCTCATTGGTTAAAGGCACACGTGAGACTTTCAGTGGGCTCTGCTGAGAAGGAAGGCAGCCCAGGAGTCAGGTATGCAGGCATTG
CATTGTCAGTGTCTGCTCTCAGAGTTTACACATTCAATTGCTTCCAAGGGTGAATCTCCTGCTCTGTGAATGCTATCAGACCCCAAAGGC
CAACCTTGGGCTGGGTCTATGTACGTTCTTCCGAAGCACTGATGATCAAAATTGAAGACACATTCAGAGGTTTGATTGGTTGAGATTAAC
TGGTGTGGTGGTTGGTGTATGTATGTTTTATTTTTATGTCTTTGTATGTAGTTCTACATAATGCAAATTGTGCTTTCTGATGGACAAGAC

>59357_59357_1_NLK-SLC39A11_NLK_chr17_26449758_ENST00000407008_SLC39A11_chr17_70944014_ENST00000255559_length(amino acids)=429AA_BP=196
MSLCGARANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAAVHPVQQHTSSAAAAAAAAAAAAAMLNPGQQ
QPYFPSPAPGQAPGPAAAAPAQVQAAAAATVKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCK
RVFRELKMLCFFKHDNGAAEDPQTTLALNFGSTLMKKKSDPEGPALLFPESELSIRIDKSENGEAYQRKKAAATGLPEGPAVPVPSRGNL
AQPGGSSWRRIALLILAITIHNVPEGLAVGVGFGAIEKTASATFESARNLAIGIGIQNFPEGLAVSLPLRGAGFSTWRAFWYGQLSGMVE

--------------------------------------------------------------
>59357_59357_2_NLK-SLC39A11_NLK_chr17_26449758_ENST00000407008_SLC39A11_chr17_70944014_ENST00000542342_length(transcript)=3663nt_BP=1306nt
CCCCGGCTCTCTTTCTCCTCTCTGTCCTGCTGTCGCCTCCTCTCCTCACTCCAGCCTCCTTCCCTGGCTTATTCTGCCCAGGAAAGTTTG
GAACCCCCGCCCCCCCTCCCCAATCAGGTCAACCTGACTAGGAGTAGGGGGAGATGTAGGAAGGCCTGAGAGTTCGGGGGGGGGGAAGCT
GGAAGCTGGTTTCCCAGAAAATTTCCCCCCATCTTCTCCATTTAGGGTGGTGGGAATTTTTTTTAATCCTGTTTTTGAGGAGGTGGTAGG
TGTTTAGAAAAGGATGTGGGAATGGAAGGGGTAGATGAGTCAACCCTCTTTCAAGATTCCAAGGGTGGTGTGTTACCTGATCCTTTTCGT
GTGTGGAGTTCAGGGGGTCGGGAGGTTTGGCCTTTATTCCCACATTCAAAGTTGGAACCTCCCCCAAATTAAGAATGGAGTTTTAGTACC
CACTTGTGGCAGGAATCCTGGGGGGAAGGGGTCCTTTTTTCCTTTTTCTTTTCTTTTTTCCCTTTTTTTTCCTTTTGGCAACCCACACCC
TTCCACACACGCTCACCCCAAAATTAAACACCAAGATCCTCTAACTTGTTTGGATTGACTGATGAAGACATAAAGCTCTATGTTTTTTGA
GGTGGAGTGAGTGGTTTTTCTTCATTTTTAAATGGCCAAATGACAGCTTGACCCAGTTTGCTTTCCAATCAAAGGGCATTTATTTTGAAT
GTCTCTTTGTGGCGCAAGAGCCAACGCAAAAATGATGGCGGCTTACAATGGCGGTACATCTGCAGCAGCAGCAGGTCACCACCACCACCA
TCACCACCACCTTCCACACCTCCCTCCTCCTCACCTGCACCACCACCACCACCCTCAACACCATCTTCATCCGGGGTCGGCTGCCGCTGT
ACACCCTGTACAGCAGCACACCTCTTCGGCAGCTGCGGCAGCCGCAGCAGCGGCTGCAGCTGCAGCCATGTTAAACCCTGGGCAACAACA
GCCATATTTCCCATCACCGGCACCGGGGCAGGCTCCTGGACCAGCTGCAGCAGCCCCAGCTCAGGTACAGGCTGCCGCAGCTGCTACAGT
TAAGGCGCACCATCATCAGCACTCGCATCATCCACAGCAGCAGCTGGATATTGAGCCGGATAGACCTATTGGATATGGAGCCTTTGGTGT
TGTCTGGTCAGTAACAGATCCAAGAGATGGAAAGAGAGTAGCGCTCAAAAAGATGCCCAACGTCTTCCAGAATCTGGTCTCTTGCAAAAG
GGTCTTCCGGGAATTGAAGATGTTGTGTTTTTTTAAGCATGATAATGGTGCAGCAGAAGACCCCCAGACGACCCTGGCACTGAACTTCGG
CTCTACGTTGATGAAGAAGAAGTCTGATCCTGAGGGTCCCGCGCTGCTCTTCCCTGAGAGTGAACTTTCCATCCGGATAGGTAGAGCTGG
GCTTCTTTCAGACAAGAGTGAGAATGGTGAGGCATATCAGAGAAAGAAGGCGGCAGCCACTGGCCTTCCAGAGGGTCCTGCTGTCCCTGT
GCCTTCTCGAGGGAATCTGGCACAGCCCGGCGGCAGCAGCTGGAGGAGGATCGCACTGCTCATCTTGGCCATCACTATACACAACGTTCC
AGAGGGTCTCGCTGTTGGAGTTGGATTTGGGGCTATAGAAAAGACGGCATCTGCTACCTTTGAGAGTGCCAGGAATTTGGCCATTGGAAT
CGGGATCCAGAATTTCCCCGAGGGCCTGGCTGTCAGCCTTCCCTTGCGAGGGGCAGGCTTCTCCACCTGGAGAGCTTTCTGGTATGGGCA
GCTGAGCGGCATGGTGGAGCCCCTGGCCGGGGTCTTTGGTGCCTTTGCCGTGGTGCTGGCTGAGCCCATCCTGCCCTACGCTCTGGCCTT
TGCTGCCGGTGCCATGGTCTACGTGGTCATGGACGACATCATCCCCGAAGCCCAGATCAGTGGTAATGGGAAACTGGCATCCTGGGCCTC
CATCCTGGGATTTGTAGTGATGATGTCACTGGACGTTGGCCTGGGCTAGGGCTGAGACGCTTCGGACCCCGGGAAAGGCCATACGAAGAA
ACAGCAGTGGTTGGCTTCTATGGGACAACAAGCTTCTTTCTTCACATTAAAACTTTTTTCCTTCCTCTCTTCTTCATCTCATTATCCTGA
TTGACTCTGATTATAATAGAACCATTTTTACTTTGCTTTGAGGGAGATTTTTGATTTAATGGGGAATTTTAAGGTGTCATGGAAATACAG
ATTCTTTGTTTTGGCCACTGAATGGACTCTCTCTTCAGTGGGATTATCAAGGAACTTCAGATCAGGGAAATCTCCACTTCGGGACCTTCT
ATCTGCCTCCCAACTCCTCAAGGTCACCTATAGAAGCGAGCTACCAAAAGACGTCTCCTAAGCATTTTGGTGGCCTAGTGACTCAGGGCA
GAGTGGCCAGCACACCTCTCATCCGCCCCTCCTGCTCCATCACTGCTGAGCCTCTCCCCATCTAGAATGTTGGAACTGGAGCATCATAAA
GATAGCAAGCTACCTTCCAAGGCCGAGCCAGCCCAGAGAGGAGCATGTCTTCCTTTACCTCCCCCTAAGGAGATACTACATGGGAGGGGG
ACACAGAAAAAGGGAAGGAAATTGGCTAGTCTGGCTTTTTTTTTTTTTTTTTTTAAAGGCAAAGATTGACATTATTGAAGGAAAGGGGAT
GAGGACAACTGTGAACTCACAGTGAGCCCTGTGGAAAGAAGAGACAGACAGAGTGTGGGTTTGTTCGGAGGCCTCTGCTGTCAATGGATT
CCAGGAGCAAGGCCATTTGTCGCGCTTTCCAAATTTCTTAGGCATTTATTTTGATAAGTTTATAGCCATCATGTTTCTAAGAGACTTGGA
GACACCAGCAAACTGCTAGAACTCAAACTCTTCAATTACTCAAAGAAGGAGCCATTTCAGTTAACTCAAGTGAATGAAAGAGTTTTGGAA
TCTGCTGTGGGTCCTTCCCTGTTGACCATTTGGTAACTTATAATCTGACAAAAACTCTTGAGCTGCAACAGGCCTTGCCAGAGGGCTCAG
GATGGGAAAGGAAGAAGGGGATAGGAAAAGAAGAGGTAATTTTACATTTCCCCTTTAAAGTAAATTTTAGCCAACTCATCATTCTGAAAT
GTCCCTATAAAGAATGAGTCGAACTAGACCAGAAGCCAGCCTACTCCTTCTTACATAGCTTCTCCAACAGGGGTAGCAATGACCTGTCCA
CTTCAAACACAGATAAGGCCTGCCATCCTCATTGGTTAAAGGCACACGTGAGACTTTCAGTGGGCTCTGCTGAGAAGGAAGGCAGCCCAG
GAGTCAGGTATGCAGGCATTGCATTGTCAGTGTCTGCTCTCAGAGTTTACACATTCAATTGCTTCCAAGGGTGAATCTCCTGCTCTGTGA
ATGCTATCAGACCCCAAAGGCCAACCTTGGGCTGGGTCTATGTACGTTCTTCCGAAGCACTGATGATCAAAATTGAAGACACATTCAGAG
GTTTGATTGGTTGAGATTAACTGGTGTGGTGGTTGGTGTATGTATGTTTTATTTTTATGTCTTTGTATGTAGTTCTACATAATGCAAATT

>59357_59357_2_NLK-SLC39A11_NLK_chr17_26449758_ENST00000407008_SLC39A11_chr17_70944014_ENST00000542342_length(amino acids)=436AA_BP=196
MSLCGARANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAAVHPVQQHTSSAAAAAAAAAAAAAMLNPGQQ
QPYFPSPAPGQAPGPAAAAPAQVQAAAAATVKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCK
RVFRELKMLCFFKHDNGAAEDPQTTLALNFGSTLMKKKSDPEGPALLFPESELSIRIGRAGLLSDKSENGEAYQRKKAAATGLPEGPAVP
VPSRGNLAQPGGSSWRRIALLILAITIHNVPEGLAVGVGFGAIEKTASATFESARNLAIGIGIQNFPEGLAVSLPLRGAGFSTWRAFWYG

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Fusion Gene PPI Analysis for NLK-SLC39A11

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for NLK-SLC39A11

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for NLK-SLC39A11

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source