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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ARHGAP12-SORCS3 (FusionGDB2 ID:5937)

Fusion Gene Summary for ARHGAP12-SORCS3

Fusion gene summary

Fusion gene information	Fusion gene name: ARHGAP12-SORCS3
	Fusion gene ID: 5937
		Hgene	Tgene
	Gene symbol	ARHGAP12	SORCS3
	Gene ID	94134	22986
	Gene name	Rho GTPase activating protein 12	sortilin related VPS10 domain containing receptor 3
	Synonyms	-	SORCS
	Cytomap	10p11.22	10q25.1
	Type of gene	protein-coding	protein-coding
	Description	rho GTPase-activating protein 12rho-type GTPase-activating protein 12	VPS10 domain-containing receptor SorCS3VPS10 domain receptor protein SORCS 3 (SORCS3)
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000311380, ENST00000344936, ENST00000375245, ENST00000375250, ENST00000396144, ENST00000492028,	ENST00000369699, ENST00000369701,
Fusion gene scores	* DoF score	9 X 8 X 7=504	3 X 3 X 2=18
	# samples	11	3
	** MAII score	log2(11/504*10)=-2.19592020997526 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ARHGAP12 [Title/Abstract] AND SORCS3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ARHGAP12(32197100)-SORCS3(106916896), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ARHGAP12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SORCS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CN-4727-01A	ARHGAP12	chr10	32197100	-	SORCS3	chr10	106916896	+

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Fusion Gene ORF analysis for ARHGAP12-SORCS3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000311380	ENST00000369699	ARHGAP12	chr10	32197100	-	SORCS3	chr10	106916896	+
5CDS-intron	ENST00000344936	ENST00000369699	ARHGAP12	chr10	32197100	-	SORCS3	chr10	106916896	+
5CDS-intron	ENST00000375245	ENST00000369699	ARHGAP12	chr10	32197100	-	SORCS3	chr10	106916896	+
5CDS-intron	ENST00000375250	ENST00000369699	ARHGAP12	chr10	32197100	-	SORCS3	chr10	106916896	+
5CDS-intron	ENST00000396144	ENST00000369699	ARHGAP12	chr10	32197100	-	SORCS3	chr10	106916896	+
Frame-shift	ENST00000344936	ENST00000369701	ARHGAP12	chr10	32197100	-	SORCS3	chr10	106916896	+
Frame-shift	ENST00000375245	ENST00000369701	ARHGAP12	chr10	32197100	-	SORCS3	chr10	106916896	+
Frame-shift	ENST00000375250	ENST00000369701	ARHGAP12	chr10	32197100	-	SORCS3	chr10	106916896	+
Frame-shift	ENST00000396144	ENST00000369701	ARHGAP12	chr10	32197100	-	SORCS3	chr10	106916896	+
In-frame	ENST00000311380	ENST00000369701	ARHGAP12	chr10	32197100	-	SORCS3	chr10	106916896	+
intron-3CDS	ENST00000492028	ENST00000369701	ARHGAP12	chr10	32197100	-	SORCS3	chr10	106916896	+
intron-intron	ENST00000492028	ENST00000369699	ARHGAP12	chr10	32197100	-	SORCS3	chr10	106916896	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000311380

ARHGAP12

chr10

32197100

ENST00000369701

SORCS3

chr10

106916896

4751

703

2889

956

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000311380	ENST00000369701	ARHGAP12	chr10	32197100	-	SORCS3	chr10	106916896	+	0.000122775	0.9998772

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Fusion Genomic Features for ARHGAP12-SORCS3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ARHGAP12	chr10	32197099	-	SORCS3	chr10	106916895	+	4.27E-07	0.9999995
ARHGAP12	chr10	32197099	-	SORCS3	chr10	106916895	+	4.27E-07	0.9999995

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARHGAP12-SORCS3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:32197100/chr10:106916896)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ARHGAP12

chr10:32197100

chr10:106916896

ENST00000311380

12_74

228

795.0

Domain

SH3

Hgene

ARHGAP12

chr10:32197100

chr10:106916896

ENST00000344936

12_74

228

847.0

Domain

SH3

Hgene

ARHGAP12

chr10:32197100

chr10:106916896

ENST00000375245

12_74

228

795.0

Domain

SH3

Hgene

ARHGAP12

chr10:32197100

chr10:106916896

ENST00000375250

12_74

228

817.0

Domain

SH3

Hgene

ARHGAP12

chr10:32197100

chr10:106916896

ENST00000396144

12_74

228

842.0

Domain

SH3

Tgene

SORCS3

chr10:32197100

chr10:106916896

ENST00000369701

827_917

494

1223.0

Domain

PKD

Tgene

SORCS3

chr10:32197100

chr10:106916896

ENST00000369701

515_526

494

1223.0

Repeat

Note=BNR 4

Tgene

SORCS3

chr10:32197100

chr10:106916896

ENST00000369701

592_603

494

1223.0

Repeat

Note=BNR 5

Tgene

SORCS3

chr10:32197100

chr10:106916896

ENST00000369701

634_645

494

1223.0

Repeat

Note=BNR 6

Tgene

SORCS3

chr10:32197100

chr10:106916896

ENST00000369701

1147_1222

494

1223.0

Topological domain

Cytoplasmic

Tgene

SORCS3

chr10:32197100

chr10:106916896

ENST00000369701

1126_1146

494

1223.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ARHGAP12

chr10:32197100

chr10:106916896

ENST00000311380

265_298

228

795.0

Domain

WW 1

Hgene

ARHGAP12

chr10:32197100

chr10:106916896

ENST00000311380

358_391

228

795.0

Domain

WW 2

Hgene

ARHGAP12

chr10:32197100

chr10:106916896

ENST00000311380

463_575

228

795.0

Domain

Hgene

ARHGAP12

chr10:32197100

chr10:106916896

ENST00000311380

656_844

228

795.0

Domain

Rho-GAP

Hgene

ARHGAP12

chr10:32197100

chr10:106916896

ENST00000344936

265_298

228

847.0

Domain

WW 1

Hgene

ARHGAP12

chr10:32197100

chr10:106916896

ENST00000344936

358_391

228

847.0

Domain

WW 2

Hgene

ARHGAP12

chr10:32197100

chr10:106916896

ENST00000344936

463_575

228

847.0

Domain

Hgene

ARHGAP12

chr10:32197100

chr10:106916896

ENST00000344936

656_844

228

847.0

Domain

Rho-GAP

Hgene

ARHGAP12

chr10:32197100

chr10:106916896

ENST00000375245

265_298

228

795.0

Domain

WW 1

Hgene

ARHGAP12

chr10:32197100

chr10:106916896

ENST00000375245

358_391

228

795.0

Domain

WW 2

Hgene

ARHGAP12

chr10:32197100

chr10:106916896

ENST00000375245

463_575

228

795.0

Domain

Hgene

ARHGAP12

chr10:32197100

chr10:106916896

ENST00000375245

656_844

228

795.0

Domain

Rho-GAP

Hgene

ARHGAP12

chr10:32197100

chr10:106916896

ENST00000375250

265_298

228

817.0

Domain

WW 1

Hgene

ARHGAP12

chr10:32197100

chr10:106916896

ENST00000375250

358_391

228

817.0

Domain

WW 2

Hgene

ARHGAP12

chr10:32197100

chr10:106916896

ENST00000375250

463_575

228

817.0

Domain

Hgene

ARHGAP12

chr10:32197100

chr10:106916896

ENST00000375250

656_844

228

817.0

Domain

Rho-GAP

Hgene

ARHGAP12

chr10:32197100

chr10:106916896

ENST00000396144

265_298

228

842.0

Domain

WW 1

Hgene

ARHGAP12

chr10:32197100

chr10:106916896

ENST00000396144

358_391

228

842.0

Domain

WW 2

Hgene

ARHGAP12

chr10:32197100

chr10:106916896

ENST00000396144

463_575

228

842.0

Domain

Hgene

ARHGAP12

chr10:32197100

chr10:106916896

ENST00000396144

656_844

228

842.0

Domain

Rho-GAP

Tgene

SORCS3

chr10:32197100

chr10:106916896

ENST00000369701

231_242

494

1223.0

Repeat

Note=BNR 1

Tgene

SORCS3

chr10:32197100

chr10:106916896

ENST00000369701

279_290

494

1223.0

Repeat

Note=BNR 2

Tgene

SORCS3

chr10:32197100

chr10:106916896

ENST00000369701

320_331

494

1223.0

Repeat

Note=BNR 3

Tgene

SORCS3

chr10:32197100

chr10:106916896

ENST00000369701

34_1125

494

1223.0

Topological domain

Lumenal

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Fusion Gene Sequence for ARHGAP12-SORCS3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>5937_5937_1_ARHGAP12-SORCS3_ARHGAP12_chr10_32197100_ENST00000311380_SORCS3_chr10_106916896_ENST00000369701_length(transcript)=4751nt_BP=703nt
GAGAGGTGAATATTATTGAATGAAAATGGCTGACAGAAGTGGGAAGATTATTCCAGGACAAGTGTATATTGAGGTGGAATATGATTATGA
ATATGAAGCAAAGGACAGAAAGATTGTGATAAAACAAGGGGAGAGGTACATCTTGGTGAAAAAGACCAATGATGACTGGTGGCAAGTCAA
GCCAGATGAAAACTCCAAAGCGTTTTATGTGCCAGCCCAGTATGTGAAGGAGGTCACGCGCAAAGCTCTCATGCCACCTGTTAAGCAGGT
AGCTGGTCTGCCAAATAACTCCACGAAAATAATGCAGAGTTTGCATCTTCAGAGATCAACAGAAAATGTGAACAAATTGCCTGAGCTTTC
AAGTTTCGGAAAGCCATCGTCATCTGTTCAAGGAACAGGTCTTATTCGTGATGCCAATCAGAATTTTGGACCCAGTTATAATCAAGGTCA
GACTGTCAACCTAAGCCTGGACCTGACCCATAATAACGGAAAGTTTAACAATGACTCACATTCTCCTAAAGTTTCCAGCCAGAATAGGAC
ACGCTCATTTGGTCATTTTCCCGGTCCAGAGTTCTTGGATGTAGAGAAAACTAGCTTCTCCCAGGAACAATCTTGTGATTCCGCAGGAGA
AGGCTCTGAAAGAATACATCAAGATTCTGAATCTGGTGATGAACTTAGCAGCAGCTCCACTGAACAGATAAGGGTAGCAGGTATCAAAGG
GATATTTCTGGCAAACAAGAAGGTGGACGACCAGGTGAAGACATACATCACTTACAACAAAGGCAGGGATTGGCGCCTGCTGCAAGCTCC
GGATGTGGACCTGAGAGGAAGCCCAGTGCACTGCCTGCTGCCCTTCTGTTCCTTACATCTGCACCTGCAACTCTCTGAAAATCCATATTC
CTCAGGAAGAATCTCTAGCAAGGAGACAGCCCCAGGACTTGTGGTGGCTACAGGCAACATTGGCCCGGAGCTCTCATATACTGATATTGG
TGTGTTCATCTCCTCCGATGGGGGCAACACATGGAGACAGATCTTTGATGAAGAGTACAATGTCTGGTTCCTAGACTGGGGTGGTGCCCT
CGTGGCCATGAAACACACACCTCTGCCAGTCAGGCATTTGTGGGTGAGTTTTGATGAGGGCCACTCTTGGGACAAGTATGGTTTCACTTC
GGTTCCTCTCTTTGTTGACGGGGCTCTGGTGGAGGCAGGAATGGAGACCCACATCATGACAGTTTTTGGCCACTTCAGCCTCCGCTCCGA
ATGGCAATTGGTGAAAGTGGACTACAAATCTATCTTCAGCCGGCATTGCACCAAGGAGGACTATCAGACCTGGCACCTGCTCAATCAGGG
AGAGCCTTGTGTCATGGGAGAAAGGAAAATATTCAAGAAACGTAAGCCAGGAGCTCAGTGTGCCCTGGGCCGAGACCACTCAGGATCAGT
GGTCTCAGAACCCTGTGTCTGTGCCAATTGGGACTTCGAGTGTGACTATGGGTATGAGAGACATGGGGAGAGCCAGTGTGTCCCAGCTTT
CTGGTACAATCCAGCATCCCCATCAAAGGACTGCAGCCTTGGTCAAAGCTACCTTAACAGCACTGGGTATCGGCGGATTGTGTCCAACAA
CTGCACAGATGGGCTAAGGGAGAAGTACACCGCCAAGGCCCAGATGTGCCCTGGAAAAGCCCCTCGGGGCCTCCATGTGGTGACGACCGA
TGGGCGGCTGGTGGCAGAGCAGGGGCACAATGCAACTTTCATCATCCTCATGGAGGAGGGTGATCTACAAAGGACAAACATCCAGCTTGA
CTTTGGGGATGGGATTGCTGTGTCCTACGCAAACTTCAGCCCCATCGAGGACGGCATCAAGCACGTGTATAAGAGTGCGGGGATCTTCCA
GGTGACAGCCTATGCAGAGAACAACCTTGGCTCAGACACAGCTGTCCTCTTCCTGCATGTGGTTTGTCCTGTGGAGCATGTTCATCTCCG
AGTTCCATTTGTTGCCATAAGAAATAAGGAGGTCAACATCAGTGCAGTCGTGTGGCCCAGTCAACTGGGGACCCTTACCTATTTCTGGTG
GTTCGGCAATAGCACAAAGCCTCTCATCACTTTGGACAGCAGCATTTCCTTCACATTCCTTGCAGAAGGAACCGACACCATCACAGTCCA
GGTGGCTGCTGGGAATGCCCTCATCCAGGACACAAAAGAGATTGCAGTTCATGAATATTTCCAGTCCCAGCTTTTATCATTCTCTCCTAA
TCTGGATTACCACAATCCTGACATTCCTGAGTGGAGAAAAGATATTGGCAATGTCATCAAGCGAGCTCTGGTTAAAGTAACCAGTGTCCC
AGAGGACCAGATCCTCATTGCCGTGTTTCCTGGTCTCCCCACTTCAGCAGAGCTTTTCATTCTTCCACCCAAGAACCTGACAGAGAGGAG
GAAAGGCAATGAAGGGGACCTGGAACAAATTGTAGAAACACTGTTTAATGCTCTCAACCAAAATTTGGTCCAGTTTGAGCTGAAGCCGGG
GGTACAAGTCATTGTGTATGTCACACAGCTGACGTTAGCTCCATTGGTGGACTCCAGTGCTGGGCACAGCAGCTCAGCCATGCTTATGCT
ATTATCAGTGGTATTTGTTGGCCTGGCTGTGTTTTTGATCTACAAGTTTAAAAGGAAAATCCCTTGGATTAACATCTATGCTCAAGTCCA
ACACGACAAGGAGCAGGAGATGATTGGGTCAGTGAGCCAAAGTGAAAACGCCCCCAAAATCACACTCAGTGACTTTACGGAGCCTGAGGA
GCTGCTGGACAAAGAGCTGGACACGCGGGTCATAGGAGGCATTGCCACTATTGCAAACAGCGAAAGCACAAAGGAGATCCCCAACTGCAC
TAGTGTTTAATACCAGCAAGCCACGTGGTCAACCACCTTTCTGACTTTTTATTTTTGATGATTACTATTACTATTATTATGGAAAAATTA
AAATGTCTTTTTTACCTTTTGTTTACCAAGGGCCCCTTCATAAATAGCAGGCAAATGCCTAGCTTTGGGAGAAAAGGGCATTCTTAGCTG
ATTGAAATGAGACAAAGGGAATAAATGGCTGTATTTGTGCTAAGAGCAAAGGATGCATCTTCCCACAGCCTCCTCGCTTTACTCTGCCAT
TGGTAGCTTAAAGACTTTCTTTTTCCTTGTGGTCTCCCTTTTTTCAAAATTGAAGTTGGGTTGGCTCTTTGTGAACCTCTCATCCCCACA
GCAGAATCACCAACACTCTCCGCTTCCCCCAGCACACACACATACAACACAGATCATTTCCCAGTTAGATCCGCAGGAAGTAGGTTGGTG
GGGGTGGATGTAGCTGCAGAAAGCATGCACAACTTTGTGAAAGAGGCCCTGCCTTGTGCATGTCCATAGTGAGGCTACAGATGGCTTATT
GTATATAATTACAATGTAAATAGCTTTTTATTTCCTAAGAAATAATTTAATGTTTAGTAAAAAAGAAAACAGAAAAAAGAAAGATGCGTG
TGTTGGCTTACGCACTGGCCCTCAGAGCTGACCAACCCGCCAGGCCTGCTCAATGCATTGGGTTTGGATGCTCTCCTGTTGTCTGTCACA
CTTAACTCTTGCATCTCCTTGTCCATGCCATAGCTGGTTTCTACTTATGTATATAAAGGGGGGTGGGGGGAGGGGCTTCTCTGGGGCAAT
TGATAAAGGAAGGACTCTAGTGACATCATAGAACATGGCAGTCGTTTTTGTTCCAAGAATGATATGAAAGGTGAAGAAGAGGCCCACTAG
AGGCTTCATACTGAGACCCAGATGGGGGAAAACAGCTTCCTCTCTAAAAGGAAAAACTTGATATTTATCAGTCTGAGAAAATATTTTTTT
CTAAAGAAGGCAGTCAGTGGATCTTAAAATGACAATCTGTTTTTAAATTGGATTCTATGAAAATGCATAATGCTTATGGTGAATTCTCAG
GCTATTCTGAGCTCAGAAAAGTCCCCTGGGCACTAGGTAAAGCCCAGTGAATGTCTCTTGGCATGGGAGGAGTTAAAGAGGTTGGAAGGG
AAGAGGCATTTGTGGAATTATGAGTTCATGCAAAACTCTCCAGGCCAAGTAGGGGTCTAGCCTTTAATGATATTAGTCAAAGGCAATTTT
AGCAAAGCTGTGCTATTTGCTTGTCAGATGTACACAACTTCCTTAAAGTCAAATGTCTGCCTTCAGTTCCCTTAAGGTAGTTCTTGCCTC
TGGGGTGAGTGGCTTTCAAAGCCTTTTAGCTTTTCCAGCACCTCAGCCCCTTCACACATTTACACATACCAATTTTTTTCAATAGGGTCA
CGTTAAGCCATGCTGTAAGCATTGTTTTTATTTTCAGGCTTAGCCTGAGCACACTTATTTTTGAAAATGATATAATGTATATATATGGGA
GGAAAGGCCACATTTTGTACCTGTTAATTTTTGTGGGATGTTGTTCCCATTCTTCTTTGTGAGACAGAGAGAATGTGATATAGAGAAATC
TGGCTGGCTACAGTGTAGATCAGTATTAGGAATATTTCTAAAGATCCTGCTTTTTTGTTTCAAGGGTTAAATGGGGCAGACAATTGCAAT
ACTTGTACTAAACACTGGAATACAAATGCATGACTCATATCTATATATACAGTATATGTACATATACTGTTCTTGGTTTTATTGTTCCAC

>5937_5937_1_ARHGAP12-SORCS3_ARHGAP12_chr10_32197100_ENST00000311380_SORCS3_chr10_106916896_ENST00000369701_length(amino acids)=956AA_BP=228
MKMADRSGKIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENSKAFYVPAQYVKEVTRKALMPPVKQVAGLPNN
STKIMQSLHLQRSTENVNKLPELSSFGKPSSSVQGTGLIRDANQNFGPSYNQGQTVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRSFGHF
PGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRVAGIKGIFLANKKVDDQVKTYITYNKGRDWRLLQAPDVDLRG
SPVHCLLPFCSLHLHLQLSENPYSSGRISSKETAPGLVVATGNIGPELSYTDIGVFISSDGGNTWRQIFDEEYNVWFLDWGGALVAMKHT
PLPVRHLWVSFDEGHSWDKYGFTSVPLFVDGALVEAGMETHIMTVFGHFSLRSEWQLVKVDYKSIFSRHCTKEDYQTWHLLNQGEPCVMG
ERKIFKKRKPGAQCALGRDHSGSVVSEPCVCANWDFECDYGYERHGESQCVPAFWYNPASPSKDCSLGQSYLNSTGYRRIVSNNCTDGLR
EKYTAKAQMCPGKAPRGLHVVTTDGRLVAEQGHNATFIILMEEGDLQRTNIQLDFGDGIAVSYANFSPIEDGIKHVYKSAGIFQVTAYAE
NNLGSDTAVLFLHVVCPVEHVHLRVPFVAIRNKEVNISAVVWPSQLGTLTYFWWFGNSTKPLITLDSSISFTFLAEGTDTITVQVAAGNA
LIQDTKEIAVHEYFQSQLLSFSPNLDYHNPDIPEWRKDIGNVIKRALVKVTSVPEDQILIAVFPGLPTSAELFILPPKNLTERRKGNEGD
LEQIVETLFNALNQNLVQFELKPGVQVIVYVTQLTLAPLVDSSAGHSSSAMLMLLSVVFVGLAVFLIYKFKRKIPWINIYAQVQHDKEQE

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Fusion Gene PPI Analysis for ARHGAP12-SORCS3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ARHGAP12-SORCS3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ARHGAP12-SORCS3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source