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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NLRC5-NUP93 (FusionGDB2 ID:59374)

Fusion Gene Summary for NLRC5-NUP93

check button Fusion gene summary
Fusion gene informationFusion gene name: NLRC5-NUP93
Fusion gene ID: 59374
HgeneTgene
Gene symbol

NLRC5

NUP93

Gene ID

84166

9688

Gene nameNLR family CARD domain containing 5nucleoporin 93
SynonymsCLR16.1|NOD27|NOD4NIC96
Cytomap

16q13

16q13

Type of geneprotein-codingprotein-coding
Descriptionprotein NLRC5NOD-like receptor C5caterpiller protein 16.1nucleotide-binding oligomerization domain protein 4nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5nucleotide-binding oligomerization domains 27nuclear pore complex protein Nup9393 kDa nucleoporinnucleoporin 93kDanucleoporin Nup93
Modification date2020031320200329
UniProtAcc

Q86WI3

.
Ensembl transtripts involved in fusion geneENST00000262510, ENST00000308149, 
ENST00000436936, ENST00000539144, 
ENST00000543141, 		ENST00000542526, 
ENST00000569595, ENST00000308159, 
ENST00000564887, ENST00000569842, 
Fusion gene scores* DoF score8 X 10 X 6=48013 X 15 X 8=1560
# samples 1017
** MAII scorelog2(10/480*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1560*10)=-3.19793937761191
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NLRC5 [Title/Abstract] AND NUP93 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNLRC5(57056227)-NUP93(56878411), # samples:2
Anticipated loss of major functional domain due to fusion event.NLRC5-NUP93 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
NLRC5-NUP93 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NLRC5-NUP93 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNLRC5

GO:0032088

negative regulation of NF-kappaB transcription factor activity

20434986

HgeneNLRC5

GO:0043549

regulation of kinase activity

20434986

HgeneNLRC5

GO:0045345

positive regulation of MHC class I biosynthetic process

20639463

HgeneNLRC5

GO:0045944

positive regulation of transcription by RNA polymerase II

20639463

HgeneNLRC5

GO:0060335

positive regulation of interferon-gamma-mediated signaling pathway

20061403

HgeneNLRC5

GO:0060339

negative regulation of type I interferon-mediated signaling pathway

20434986

HgeneNLRC5

GO:0060340

positive regulation of type I interferon-mediated signaling pathway

20061403

TgeneNUP93

GO:0006998

nuclear envelope organization

26878725

TgeneNUP93

GO:0051292

nuclear pore complex assembly

26878725

TgeneNUP93

GO:0060391

positive regulation of SMAD protein signal transduction

26878725

TgeneNUP93

GO:0060395

SMAD protein signal transduction

26878725


check buttonFusion gene breakpoints across NLRC5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NUP93 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-PK-A5HA-01ANLRC5chr16

57056227

-NUP93chr16

56878411

+
ChimerDB4ACCTCGA-PK-A5HA-01ANLRC5chr16

57056227

+NUP93chr16

56878411

+


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Fusion Gene ORF analysis for NLRC5-NUP93

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262510ENST00000542526NLRC5chr16

57056227

+NUP93chr16

56878411

+
5CDS-intronENST00000262510ENST00000569595NLRC5chr16

57056227

+NUP93chr16

56878411

+
5CDS-intronENST00000308149ENST00000542526NLRC5chr16

57056227

+NUP93chr16

56878411

+
5CDS-intronENST00000308149ENST00000569595NLRC5chr16

57056227

+NUP93chr16

56878411

+
5CDS-intronENST00000436936ENST00000542526NLRC5chr16

57056227

+NUP93chr16

56878411

+
5CDS-intronENST00000436936ENST00000569595NLRC5chr16

57056227

+NUP93chr16

56878411

+
5CDS-intronENST00000539144ENST00000542526NLRC5chr16

57056227

+NUP93chr16

56878411

+
5CDS-intronENST00000539144ENST00000569595NLRC5chr16

57056227

+NUP93chr16

56878411

+
Frame-shiftENST00000262510ENST00000308159NLRC5chr16

57056227

+NUP93chr16

56878411

+
Frame-shiftENST00000308149ENST00000308159NLRC5chr16

57056227

+NUP93chr16

56878411

+
Frame-shiftENST00000436936ENST00000308159NLRC5chr16

57056227

+NUP93chr16

56878411

+
Frame-shiftENST00000539144ENST00000308159NLRC5chr16

57056227

+NUP93chr16

56878411

+
In-frameENST00000262510ENST00000564887NLRC5chr16

57056227

+NUP93chr16

56878411

+
In-frameENST00000262510ENST00000569842NLRC5chr16

57056227

+NUP93chr16

56878411

+
In-frameENST00000308149ENST00000564887NLRC5chr16

57056227

+NUP93chr16

56878411

+
In-frameENST00000308149ENST00000569842NLRC5chr16

57056227

+NUP93chr16

56878411

+
In-frameENST00000436936ENST00000564887NLRC5chr16

57056227

+NUP93chr16

56878411

+
In-frameENST00000436936ENST00000569842NLRC5chr16

57056227

+NUP93chr16

56878411

+
In-frameENST00000539144ENST00000564887NLRC5chr16

57056227

+NUP93chr16

56878411

+
In-frameENST00000539144ENST00000569842NLRC5chr16

57056227

+NUP93chr16

56878411

+
intron-3CDSENST00000543141ENST00000308159NLRC5chr16

57056227

+NUP93chr16

56878411

+
intron-3CDSENST00000543141ENST00000564887NLRC5chr16

57056227

+NUP93chr16

56878411

+
intron-3CDSENST00000543141ENST00000569842NLRC5chr16

57056227

+NUP93chr16

56878411

+
intron-intronENST00000543141ENST00000542526NLRC5chr16

57056227

+NUP93chr16

56878411

+
intron-intronENST00000543141ENST00000569595NLRC5chr16

57056227

+NUP93chr16

56878411

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262510NLRC5chr1657056227+ENST00000569842NUP93chr1656878411+851580225755176
ENST00000262510NLRC5chr1657056227+ENST00000564887NUP93chr1656878411+846580225755176
ENST00000436936NLRC5chr1657056227+ENST00000569842NUP93chr1656878411+851580225755176
ENST00000436936NLRC5chr1657056227+ENST00000564887NUP93chr1656878411+846580225755176
ENST00000308149NLRC5chr1657056227+ENST00000569842NUP93chr1656878411+851580225755176
ENST00000308149NLRC5chr1657056227+ENST00000564887NUP93chr1656878411+846580225755176
ENST00000539144NLRC5chr1657056227+ENST00000569842NUP93chr1656878411+6263550530176
ENST00000539144NLRC5chr1657056227+ENST00000564887NUP93chr1656878411+6213550530176

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262510ENST00000569842NLRC5chr1657056227+NUP93chr1656878411+0.08062720.91937274
ENST00000262510ENST00000564887NLRC5chr1657056227+NUP93chr1656878411+0.0850060660.91499394
ENST00000436936ENST00000569842NLRC5chr1657056227+NUP93chr1656878411+0.08062720.91937274
ENST00000436936ENST00000564887NLRC5chr1657056227+NUP93chr1656878411+0.0850060660.91499394
ENST00000308149ENST00000569842NLRC5chr1657056227+NUP93chr1656878411+0.08062720.91937274
ENST00000308149ENST00000564887NLRC5chr1657056227+NUP93chr1656878411+0.0850060660.91499394
ENST00000539144ENST00000569842NLRC5chr1657056227+NUP93chr1656878411+0.173043920.8269561
ENST00000539144ENST00000564887NLRC5chr1657056227+NUP93chr1656878411+0.174493180.8255068

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Fusion Genomic Features for NLRC5-NUP93


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NLRC5chr1657056227+NUP93chr1656878410+5.91E-050.9999409
NLRC5chr1657056227+NUP93chr1656878410+5.91E-050.9999409

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NLRC5-NUP93


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:57056227/chr16:56878411)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NLRC5

Q86WI3

.
FUNCTION: Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. {ECO:0000269|PubMed:20061403, ECO:0000269|PubMed:20434986}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+449222_5391181867.0DomainNACHT
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+448222_5391181838.0DomainNACHT
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+449222_5391181294.6666666666667DomainNACHT
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+246222_5391181838.0DomainNACHT
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+449228_2351181867.0Nucleotide bindingATP
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+448228_2351181838.0Nucleotide bindingATP
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+449228_2351181294.6666666666667Nucleotide bindingATP
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+246228_2351181838.0Nucleotide bindingATP
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+4491004_10261181867.0RepeatNote=LRR 9
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+4491031_10581181867.0RepeatNote=LRR 10
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+4491138_11611181867.0RepeatNote=LRR 11
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+4491162_11841181867.0RepeatNote=LRR 12
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+4491242_12651181867.0RepeatNote=LRR 13
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+4491272_12941181867.0RepeatNote=LRR 14
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+4491462_14881181867.0RepeatNote=LRR 15
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+4491493_15161181867.0RepeatNote=LRR 16
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+4491521_15441181867.0RepeatNote=LRR 17
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+4491554_15771181867.0RepeatNote=LRR 18
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+4491578_16001181867.0RepeatNote=LRR 19
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+4491605_16281181867.0RepeatNote=LRR 20
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+4491633_16561181867.0RepeatNote=LRR 21
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+4491661_16841181867.0RepeatNote=LRR 22
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+4491687_17141181867.0RepeatNote=LRR 23
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+4491715_17391181867.0RepeatNote=LRR 24
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+4491741_17621181867.0RepeatNote=LRR 25
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+4491795_18181181867.0RepeatNote=LRR 26
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+449599_6221181867.0RepeatNote=LRR 1
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+449713_7371181867.0RepeatNote=LRR 2
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+449741_7651181867.0RepeatNote=LRR 3
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+449769_7921181867.0RepeatNote=LRR 4
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+449869_8921181867.0RepeatNote=LRR 5
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+449897_9211181867.0RepeatNote=LRR 6
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+449930_9531181867.0RepeatNote=LRR 7
HgeneNLRC5chr16:57056227chr16:56878411ENST00000262510+449976_10001181867.0RepeatNote=LRR 8
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+4481004_10261181838.0RepeatNote=LRR 9
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+4481031_10581181838.0RepeatNote=LRR 10
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+4481138_11611181838.0RepeatNote=LRR 11
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+4481162_11841181838.0RepeatNote=LRR 12
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+4481242_12651181838.0RepeatNote=LRR 13
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+4481272_12941181838.0RepeatNote=LRR 14
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+4481462_14881181838.0RepeatNote=LRR 15
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+4481493_15161181838.0RepeatNote=LRR 16
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+4481521_15441181838.0RepeatNote=LRR 17
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+4481554_15771181838.0RepeatNote=LRR 18
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+4481578_16001181838.0RepeatNote=LRR 19
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+4481605_16281181838.0RepeatNote=LRR 20
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+4481633_16561181838.0RepeatNote=LRR 21
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+4481661_16841181838.0RepeatNote=LRR 22
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+4481687_17141181838.0RepeatNote=LRR 23
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+4481715_17391181838.0RepeatNote=LRR 24
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+4481741_17621181838.0RepeatNote=LRR 25
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+4481795_18181181838.0RepeatNote=LRR 26
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+448599_6221181838.0RepeatNote=LRR 1
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+448713_7371181838.0RepeatNote=LRR 2
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+448741_7651181838.0RepeatNote=LRR 3
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+448769_7921181838.0RepeatNote=LRR 4
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+448869_8921181838.0RepeatNote=LRR 5
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+448897_9211181838.0RepeatNote=LRR 6
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+448930_9531181838.0RepeatNote=LRR 7
HgeneNLRC5chr16:57056227chr16:56878411ENST00000308149+448976_10001181838.0RepeatNote=LRR 8
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+4491004_10261181294.6666666666667RepeatNote=LRR 9
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+4491031_10581181294.6666666666667RepeatNote=LRR 10
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+4491138_11611181294.6666666666667RepeatNote=LRR 11
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+4491162_11841181294.6666666666667RepeatNote=LRR 12
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+4491242_12651181294.6666666666667RepeatNote=LRR 13
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+4491272_12941181294.6666666666667RepeatNote=LRR 14
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+4491462_14881181294.6666666666667RepeatNote=LRR 15
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+4491493_15161181294.6666666666667RepeatNote=LRR 16
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+4491521_15441181294.6666666666667RepeatNote=LRR 17
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+4491554_15771181294.6666666666667RepeatNote=LRR 18
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+4491578_16001181294.6666666666667RepeatNote=LRR 19
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+4491605_16281181294.6666666666667RepeatNote=LRR 20
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+4491633_16561181294.6666666666667RepeatNote=LRR 21
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+4491661_16841181294.6666666666667RepeatNote=LRR 22
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+4491687_17141181294.6666666666667RepeatNote=LRR 23
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+4491715_17391181294.6666666666667RepeatNote=LRR 24
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+4491741_17621181294.6666666666667RepeatNote=LRR 25
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+4491795_18181181294.6666666666667RepeatNote=LRR 26
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+449599_6221181294.6666666666667RepeatNote=LRR 1
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+449713_7371181294.6666666666667RepeatNote=LRR 2
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+449741_7651181294.6666666666667RepeatNote=LRR 3
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+449769_7921181294.6666666666667RepeatNote=LRR 4
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+449869_8921181294.6666666666667RepeatNote=LRR 5
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+449897_9211181294.6666666666667RepeatNote=LRR 6
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+449930_9531181294.6666666666667RepeatNote=LRR 7
HgeneNLRC5chr16:57056227chr16:56878411ENST00000436936+449976_10001181294.6666666666667RepeatNote=LRR 8
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+2461004_10261181838.0RepeatNote=LRR 9
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+2461031_10581181838.0RepeatNote=LRR 10
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+2461138_11611181838.0RepeatNote=LRR 11
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+2461162_11841181838.0RepeatNote=LRR 12
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+2461242_12651181838.0RepeatNote=LRR 13
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+2461272_12941181838.0RepeatNote=LRR 14
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+2461462_14881181838.0RepeatNote=LRR 15
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+2461493_15161181838.0RepeatNote=LRR 16
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+2461521_15441181838.0RepeatNote=LRR 17
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+2461554_15771181838.0RepeatNote=LRR 18
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+2461578_16001181838.0RepeatNote=LRR 19
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+2461605_16281181838.0RepeatNote=LRR 20
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+2461633_16561181838.0RepeatNote=LRR 21
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+2461661_16841181838.0RepeatNote=LRR 22
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+2461687_17141181838.0RepeatNote=LRR 23
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+2461715_17391181838.0RepeatNote=LRR 24
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+2461741_17621181838.0RepeatNote=LRR 25
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+2461795_18181181838.0RepeatNote=LRR 26
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+246599_6221181838.0RepeatNote=LRR 1
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+246713_7371181838.0RepeatNote=LRR 2
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+246741_7651181838.0RepeatNote=LRR 3
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+246769_7921181838.0RepeatNote=LRR 4
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+246869_8921181838.0RepeatNote=LRR 5
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+246897_9211181838.0RepeatNote=LRR 6
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+246930_9531181838.0RepeatNote=LRR 7
HgeneNLRC5chr16:57056227chr16:56878411ENST00000539144+246976_10001181838.0RepeatNote=LRR 8


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Fusion Gene Sequence for NLRC5-NUP93


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>59374_59374_1_NLRC5-NUP93_NLRC5_chr16_57056227_ENST00000262510_NUP93_chr16_56878411_ENST00000564887_length(transcript)=846nt_BP=580nt
GCAGCAGCCGCCAGTTCCATGCACTGGCGGAGCAGCTCTAGGCGGCGGCTTCTACTTTCAGTTTCGTGCAGAGCGCGGAGGAGCCGCGAG
CGCTGAGGGAGTCTGCACTATGGAAACAACCTGTCAATCCAGCTCAAGGCACACATAGCCCAGACACCCATGAGACCCTCTCCGTGGGGA
CCCTAGAGCACCTATCATGAACGAGGAGACCAAGGCTGGCTCCTCATGGACCCCGTTGGCCTCCAGCTCGGCAACAAGAACCTGTGGAGC
TGTCTTGTGAGGCTGCTCACCAAAGACCCAGAATGGCTGAACGCCAAGATGAAGTTCTTCCTCCCCAACACGGACCTGGATTCCAGGAAC
GAGACCTTGGACCCTGAACAGAGAGTCATCCTGCAACTCAACAAGCTGCATGTCCAGGGTTCGGACACCTGGCAGTCTTTCATTCATTGT
GTGTGCATGCAGCTGGAGGTGCCTCTGGACCTGGAGGTGCTGCTGCTGAGTACTTTTGGCTATGATGATGGGTTCACCAGCCAGCTGGGA
GCTGAGGGGAAAAGCCAACCTGAATCTCAGCTCCACCATGCAACTCCGAAGTCAAGCCCGCACTCTGATTACCTTTGCTGGAATGATACC
ATACCGAACGTCTGGGGACACCAATGCGAGGCTGGTGCAGATGGAGGTCCTCATGAATTAAGTGCCATGCTTTGTGGGAGTCTGGGTCGG
CACACTGTCAGTACATCAGGCACATGGGCCCACTAGGCTGGGGTTTCTGGTTTTGTTTCTGTTGTGTTTTGTTTTGGTTTCTGTATTATG

>59374_59374_1_NLRC5-NUP93_NLRC5_chr16_57056227_ENST00000262510_NUP93_chr16_56878411_ENST00000564887_length(amino acids)=176AA_BP=118
MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQLEVPLDLEVLL

--------------------------------------------------------------
>59374_59374_2_NLRC5-NUP93_NLRC5_chr16_57056227_ENST00000262510_NUP93_chr16_56878411_ENST00000569842_length(transcript)=851nt_BP=580nt
GCAGCAGCCGCCAGTTCCATGCACTGGCGGAGCAGCTCTAGGCGGCGGCTTCTACTTTCAGTTTCGTGCAGAGCGCGGAGGAGCCGCGAG
CGCTGAGGGAGTCTGCACTATGGAAACAACCTGTCAATCCAGCTCAAGGCACACATAGCCCAGACACCCATGAGACCCTCTCCGTGGGGA
CCCTAGAGCACCTATCATGAACGAGGAGACCAAGGCTGGCTCCTCATGGACCCCGTTGGCCTCCAGCTCGGCAACAAGAACCTGTGGAGC
TGTCTTGTGAGGCTGCTCACCAAAGACCCAGAATGGCTGAACGCCAAGATGAAGTTCTTCCTCCCCAACACGGACCTGGATTCCAGGAAC
GAGACCTTGGACCCTGAACAGAGAGTCATCCTGCAACTCAACAAGCTGCATGTCCAGGGTTCGGACACCTGGCAGTCTTTCATTCATTGT
GTGTGCATGCAGCTGGAGGTGCCTCTGGACCTGGAGGTGCTGCTGCTGAGTACTTTTGGCTATGATGATGGGTTCACCAGCCAGCTGGGA
GCTGAGGGGAAAAGCCAACCTGAATCTCAGCTCCACCATGCAACTCCGAAGTCAAGCCCGCACTCTGATTACCTTTGCTGGAATGATACC
ATACCGAACGTCTGGGGACACCAATGCGAGGCTGGTGCAGATGGAGGTCCTCATGAATTAAGTGCCATGCTTTGTGGGAGTCTGGGTCGG
CACACTGTCAGTACATCAGGCACATGGGCCCACTAGGCTGGGGTTTCTGGTTTTGTTTCTGTTGTGTTTTGTTTTGGTTTCTGTATTATG

>59374_59374_2_NLRC5-NUP93_NLRC5_chr16_57056227_ENST00000262510_NUP93_chr16_56878411_ENST00000569842_length(amino acids)=176AA_BP=118
MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQLEVPLDLEVLL

--------------------------------------------------------------
>59374_59374_3_NLRC5-NUP93_NLRC5_chr16_57056227_ENST00000308149_NUP93_chr16_56878411_ENST00000564887_length(transcript)=846nt_BP=580nt
GCAGCAGCCGCCAGTTCCATGCACTGGCGGAGCAGCTCTAGGCGGCGGCTTCTACTTTCAGTTTCGTGCAGAGCGCGGAGGAGCCGCGAG
CGCTGAGGGAGTCTGCACTATGGAAACAACCTGTCAATCCAGCTCAAGGCACACATAGCCCAGACACCCATGAGACCCTCTCCGTGGGGA
CCCTAGAGCACCTATCATGAACGAGGAGACCAAGGCTGGCTCCTCATGGACCCCGTTGGCCTCCAGCTCGGCAACAAGAACCTGTGGAGC
TGTCTTGTGAGGCTGCTCACCAAAGACCCAGAATGGCTGAACGCCAAGATGAAGTTCTTCCTCCCCAACACGGACCTGGATTCCAGGAAC
GAGACCTTGGACCCTGAACAGAGAGTCATCCTGCAACTCAACAAGCTGCATGTCCAGGGTTCGGACACCTGGCAGTCTTTCATTCATTGT
GTGTGCATGCAGCTGGAGGTGCCTCTGGACCTGGAGGTGCTGCTGCTGAGTACTTTTGGCTATGATGATGGGTTCACCAGCCAGCTGGGA
GCTGAGGGGAAAAGCCAACCTGAATCTCAGCTCCACCATGCAACTCCGAAGTCAAGCCCGCACTCTGATTACCTTTGCTGGAATGATACC
ATACCGAACGTCTGGGGACACCAATGCGAGGCTGGTGCAGATGGAGGTCCTCATGAATTAAGTGCCATGCTTTGTGGGAGTCTGGGTCGG
CACACTGTCAGTACATCAGGCACATGGGCCCACTAGGCTGGGGTTTCTGGTTTTGTTTCTGTTGTGTTTTGTTTTGGTTTCTGTATTATG

>59374_59374_3_NLRC5-NUP93_NLRC5_chr16_57056227_ENST00000308149_NUP93_chr16_56878411_ENST00000564887_length(amino acids)=176AA_BP=118
MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQLEVPLDLEVLL

--------------------------------------------------------------
>59374_59374_4_NLRC5-NUP93_NLRC5_chr16_57056227_ENST00000308149_NUP93_chr16_56878411_ENST00000569842_length(transcript)=851nt_BP=580nt
GCAGCAGCCGCCAGTTCCATGCACTGGCGGAGCAGCTCTAGGCGGCGGCTTCTACTTTCAGTTTCGTGCAGAGCGCGGAGGAGCCGCGAG
CGCTGAGGGAGTCTGCACTATGGAAACAACCTGTCAATCCAGCTCAAGGCACACATAGCCCAGACACCCATGAGACCCTCTCCGTGGGGA
CCCTAGAGCACCTATCATGAACGAGGAGACCAAGGCTGGCTCCTCATGGACCCCGTTGGCCTCCAGCTCGGCAACAAGAACCTGTGGAGC
TGTCTTGTGAGGCTGCTCACCAAAGACCCAGAATGGCTGAACGCCAAGATGAAGTTCTTCCTCCCCAACACGGACCTGGATTCCAGGAAC
GAGACCTTGGACCCTGAACAGAGAGTCATCCTGCAACTCAACAAGCTGCATGTCCAGGGTTCGGACACCTGGCAGTCTTTCATTCATTGT
GTGTGCATGCAGCTGGAGGTGCCTCTGGACCTGGAGGTGCTGCTGCTGAGTACTTTTGGCTATGATGATGGGTTCACCAGCCAGCTGGGA
GCTGAGGGGAAAAGCCAACCTGAATCTCAGCTCCACCATGCAACTCCGAAGTCAAGCCCGCACTCTGATTACCTTTGCTGGAATGATACC
ATACCGAACGTCTGGGGACACCAATGCGAGGCTGGTGCAGATGGAGGTCCTCATGAATTAAGTGCCATGCTTTGTGGGAGTCTGGGTCGG
CACACTGTCAGTACATCAGGCACATGGGCCCACTAGGCTGGGGTTTCTGGTTTTGTTTCTGTTGTGTTTTGTTTTGGTTTCTGTATTATG

>59374_59374_4_NLRC5-NUP93_NLRC5_chr16_57056227_ENST00000308149_NUP93_chr16_56878411_ENST00000569842_length(amino acids)=176AA_BP=118
MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQLEVPLDLEVLL

--------------------------------------------------------------
>59374_59374_5_NLRC5-NUP93_NLRC5_chr16_57056227_ENST00000436936_NUP93_chr16_56878411_ENST00000564887_length(transcript)=846nt_BP=580nt
GCAGCAGCCGCCAGTTCCATGCACTGGCGGAGCAGCTCTAGGCGGCGGCTTCTACTTTCAGTTTCGTGCAGAGCGCGGAGGAGCCGCGAG
CGCTGAGGGAGTCTGCACTATGGAAACAACCTGTCAATCCAGCTCAAGGCACACATAGCCCAGACACCCATGAGACCCTCTCCGTGGGGA
CCCTAGAGCACCTATCATGAACGAGGAGACCAAGGCTGGCTCCTCATGGACCCCGTTGGCCTCCAGCTCGGCAACAAGAACCTGTGGAGC
TGTCTTGTGAGGCTGCTCACCAAAGACCCAGAATGGCTGAACGCCAAGATGAAGTTCTTCCTCCCCAACACGGACCTGGATTCCAGGAAC
GAGACCTTGGACCCTGAACAGAGAGTCATCCTGCAACTCAACAAGCTGCATGTCCAGGGTTCGGACACCTGGCAGTCTTTCATTCATTGT
GTGTGCATGCAGCTGGAGGTGCCTCTGGACCTGGAGGTGCTGCTGCTGAGTACTTTTGGCTATGATGATGGGTTCACCAGCCAGCTGGGA
GCTGAGGGGAAAAGCCAACCTGAATCTCAGCTCCACCATGCAACTCCGAAGTCAAGCCCGCACTCTGATTACCTTTGCTGGAATGATACC
ATACCGAACGTCTGGGGACACCAATGCGAGGCTGGTGCAGATGGAGGTCCTCATGAATTAAGTGCCATGCTTTGTGGGAGTCTGGGTCGG
CACACTGTCAGTACATCAGGCACATGGGCCCACTAGGCTGGGGTTTCTGGTTTTGTTTCTGTTGTGTTTTGTTTTGGTTTCTGTATTATG

>59374_59374_5_NLRC5-NUP93_NLRC5_chr16_57056227_ENST00000436936_NUP93_chr16_56878411_ENST00000564887_length(amino acids)=176AA_BP=118
MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQLEVPLDLEVLL

--------------------------------------------------------------
>59374_59374_6_NLRC5-NUP93_NLRC5_chr16_57056227_ENST00000436936_NUP93_chr16_56878411_ENST00000569842_length(transcript)=851nt_BP=580nt
GCAGCAGCCGCCAGTTCCATGCACTGGCGGAGCAGCTCTAGGCGGCGGCTTCTACTTTCAGTTTCGTGCAGAGCGCGGAGGAGCCGCGAG
CGCTGAGGGAGTCTGCACTATGGAAACAACCTGTCAATCCAGCTCAAGGCACACATAGCCCAGACACCCATGAGACCCTCTCCGTGGGGA
CCCTAGAGCACCTATCATGAACGAGGAGACCAAGGCTGGCTCCTCATGGACCCCGTTGGCCTCCAGCTCGGCAACAAGAACCTGTGGAGC
TGTCTTGTGAGGCTGCTCACCAAAGACCCAGAATGGCTGAACGCCAAGATGAAGTTCTTCCTCCCCAACACGGACCTGGATTCCAGGAAC
GAGACCTTGGACCCTGAACAGAGAGTCATCCTGCAACTCAACAAGCTGCATGTCCAGGGTTCGGACACCTGGCAGTCTTTCATTCATTGT
GTGTGCATGCAGCTGGAGGTGCCTCTGGACCTGGAGGTGCTGCTGCTGAGTACTTTTGGCTATGATGATGGGTTCACCAGCCAGCTGGGA
GCTGAGGGGAAAAGCCAACCTGAATCTCAGCTCCACCATGCAACTCCGAAGTCAAGCCCGCACTCTGATTACCTTTGCTGGAATGATACC
ATACCGAACGTCTGGGGACACCAATGCGAGGCTGGTGCAGATGGAGGTCCTCATGAATTAAGTGCCATGCTTTGTGGGAGTCTGGGTCGG
CACACTGTCAGTACATCAGGCACATGGGCCCACTAGGCTGGGGTTTCTGGTTTTGTTTCTGTTGTGTTTTGTTTTGGTTTCTGTATTATG

>59374_59374_6_NLRC5-NUP93_NLRC5_chr16_57056227_ENST00000436936_NUP93_chr16_56878411_ENST00000569842_length(amino acids)=176AA_BP=118
MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQLEVPLDLEVLL

--------------------------------------------------------------
>59374_59374_7_NLRC5-NUP93_NLRC5_chr16_57056227_ENST00000539144_NUP93_chr16_56878411_ENST00000564887_length(transcript)=621nt_BP=355nt
ATGGACCCCGTTGGCCTCCAGCTCGGCAACAAGAACCTGTGGAGCTGTCTTGTGAGGCTGCTCACCAAAGACCCAGAATGGCTGAACGCC
AAGATGAAGTTCTTCCTCCCCAACACGGACCTGGATTCCAGGAACGAGACCTTGGACCCTGAACAGAGAGTCATCCTGCAACTCAACAAG
CTGCATGTCCAGGGTTCGGACACCTGGCAGTCTTTCATTCATTGTGTGTGCATGCAGCTGGAGGTGCCTCTGGACCTGGAGGTGCTGCTG
CTGAGTACTTTTGGCTATGATGATGGGTTCACCAGCCAGCTGGGAGCTGAGGGGAAAAGCCAACCTGAATCTCAGCTCCACCATGCAACT
CCGAAGTCAAGCCCGCACTCTGATTACCTTTGCTGGAATGATACCATACCGAACGTCTGGGGACACCAATGCGAGGCTGGTGCAGATGGA
GGTCCTCATGAATTAAGTGCCATGCTTTGTGGGAGTCTGGGTCGGCACACTGTCAGTACATCAGGCACATGGGCCCACTAGGCTGGGGTT

>59374_59374_7_NLRC5-NUP93_NLRC5_chr16_57056227_ENST00000539144_NUP93_chr16_56878411_ENST00000564887_length(amino acids)=176AA_BP=118
MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQLEVPLDLEVLL

--------------------------------------------------------------
>59374_59374_8_NLRC5-NUP93_NLRC5_chr16_57056227_ENST00000539144_NUP93_chr16_56878411_ENST00000569842_length(transcript)=626nt_BP=355nt
ATGGACCCCGTTGGCCTCCAGCTCGGCAACAAGAACCTGTGGAGCTGTCTTGTGAGGCTGCTCACCAAAGACCCAGAATGGCTGAACGCC
AAGATGAAGTTCTTCCTCCCCAACACGGACCTGGATTCCAGGAACGAGACCTTGGACCCTGAACAGAGAGTCATCCTGCAACTCAACAAG
CTGCATGTCCAGGGTTCGGACACCTGGCAGTCTTTCATTCATTGTGTGTGCATGCAGCTGGAGGTGCCTCTGGACCTGGAGGTGCTGCTG
CTGAGTACTTTTGGCTATGATGATGGGTTCACCAGCCAGCTGGGAGCTGAGGGGAAAAGCCAACCTGAATCTCAGCTCCACCATGCAACT
CCGAAGTCAAGCCCGCACTCTGATTACCTTTGCTGGAATGATACCATACCGAACGTCTGGGGACACCAATGCGAGGCTGGTGCAGATGGA
GGTCCTCATGAATTAAGTGCCATGCTTTGTGGGAGTCTGGGTCGGCACACTGTCAGTACATCAGGCACATGGGCCCACTAGGCTGGGGTT

>59374_59374_8_NLRC5-NUP93_NLRC5_chr16_57056227_ENST00000539144_NUP93_chr16_56878411_ENST00000569842_length(amino acids)=176AA_BP=118
MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQLEVPLDLEVLL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NLRC5-NUP93


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NLRC5-NUP93


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NLRC5-NUP93


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource