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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NMD3-USP40 (FusionGDB2 ID:59403)

Fusion Gene Summary for NMD3-USP40

check button Fusion gene summary
Fusion gene informationFusion gene name: NMD3-USP40
Fusion gene ID: 59403
HgeneTgene
Gene symbol

NMD3

USP40

Gene ID

51068

55230

Gene nameNMD3 ribosome export adaptorubiquitin specific peptidase 40
SynonymsCGI-07-
Cytomap

3q26.1

2q37.1

Type of geneprotein-codingprotein-coding
Description60S ribosomal export protein NMD3NMD3 homologhNMD3ubiquitin carboxyl-terminal hydrolase 40deubiquitinating enzyme 40ubiquitin specific protease 40ubiquitin thioesterase 40ubiquitin thiolesterase 40ubiquitin-specific-processing protease 40
Modification date2020031320200313
UniProtAcc

Q96D46

.
Ensembl transtripts involved in fusion geneENST00000478160, ENST00000351193, 
ENST00000460469, ENST00000472947, 
ENST00000251722, ENST00000427112, 
ENST00000450966, ENST00000409945, 
ENST00000443711, ENST00000496298, 
Fusion gene scores* DoF score9 X 9 X 5=4059 X 9 X 4=324
# samples 99
** MAII scorelog2(9/405*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/324*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NMD3 [Title/Abstract] AND USP40 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNMD3(160953000)-USP40(234407258), # samples:5
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NMD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across USP40 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-ZS-A9CF-01ANMD3chr3

160953000

-USP40chr2

234407258

-
ChimerDB4LIHCTCGA-ZS-A9CF-01ANMD3chr3

160953000

+USP40chr2

234407258

-
ChimerDB4LIHCTCGA-ZS-A9CF-02ANMD3chr3

160953000

-USP40chr2

234407258

-
ChimerDB4LIHCTCGA-ZS-A9CF-02ANMD3chr3

160953000

+USP40chr2

234407258

-


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Fusion Gene ORF analysis for NMD3-USP40

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000478160ENST00000251722NMD3chr3

160953000

+USP40chr2

234407258

-
3UTR-3CDSENST00000478160ENST00000427112NMD3chr3

160953000

+USP40chr2

234407258

-
3UTR-3CDSENST00000478160ENST00000450966NMD3chr3

160953000

+USP40chr2

234407258

-
3UTR-intronENST00000478160ENST00000409945NMD3chr3

160953000

+USP40chr2

234407258

-
3UTR-intronENST00000478160ENST00000443711NMD3chr3

160953000

+USP40chr2

234407258

-
3UTR-intronENST00000478160ENST00000496298NMD3chr3

160953000

+USP40chr2

234407258

-
5CDS-intronENST00000351193ENST00000409945NMD3chr3

160953000

+USP40chr2

234407258

-
5CDS-intronENST00000351193ENST00000443711NMD3chr3

160953000

+USP40chr2

234407258

-
5CDS-intronENST00000351193ENST00000496298NMD3chr3

160953000

+USP40chr2

234407258

-
5CDS-intronENST00000460469ENST00000409945NMD3chr3

160953000

+USP40chr2

234407258

-
5CDS-intronENST00000460469ENST00000443711NMD3chr3

160953000

+USP40chr2

234407258

-
5CDS-intronENST00000460469ENST00000496298NMD3chr3

160953000

+USP40chr2

234407258

-
5CDS-intronENST00000472947ENST00000409945NMD3chr3

160953000

+USP40chr2

234407258

-
5CDS-intronENST00000472947ENST00000443711NMD3chr3

160953000

+USP40chr2

234407258

-
5CDS-intronENST00000472947ENST00000496298NMD3chr3

160953000

+USP40chr2

234407258

-
In-frameENST00000351193ENST00000251722NMD3chr3

160953000

+USP40chr2

234407258

-
In-frameENST00000351193ENST00000427112NMD3chr3

160953000

+USP40chr2

234407258

-
In-frameENST00000351193ENST00000450966NMD3chr3

160953000

+USP40chr2

234407258

-
In-frameENST00000460469ENST00000251722NMD3chr3

160953000

+USP40chr2

234407258

-
In-frameENST00000460469ENST00000427112NMD3chr3

160953000

+USP40chr2

234407258

-
In-frameENST00000460469ENST00000450966NMD3chr3

160953000

+USP40chr2

234407258

-
In-frameENST00000472947ENST00000251722NMD3chr3

160953000

+USP40chr2

234407258

-
In-frameENST00000472947ENST00000427112NMD3chr3

160953000

+USP40chr2

234407258

-
In-frameENST00000472947ENST00000450966NMD3chr3

160953000

+USP40chr2

234407258

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000351193NMD3chr3160953000+ENST00000450966USP40chr2234407258-3650717231777584
ENST00000351193NMD3chr3160953000+ENST00000251722USP40chr2234407258-3644717231777584
ENST00000351193NMD3chr3160953000+ENST00000427112USP40chr2234407258-1778717231777585
ENST00000472947NMD3chr3160953000+ENST00000450966USP40chr2234407258-363269951759584
ENST00000472947NMD3chr3160953000+ENST00000251722USP40chr2234407258-362669951759584
ENST00000472947NMD3chr3160953000+ENST00000427112USP40chr2234407258-176069951759585
ENST00000460469NMD3chr3160953000+ENST00000450966USP40chr2234407258-396510324552092545
ENST00000460469NMD3chr3160953000+ENST00000251722USP40chr2234407258-395910324552092545
ENST00000460469NMD3chr3160953000+ENST00000427112USP40chr2234407258-209310324552092546

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000351193ENST00000450966NMD3chr3160953000+USP40chr2234407258-0.0125587270.9874413
ENST00000351193ENST00000251722NMD3chr3160953000+USP40chr2234407258-0.0123282890.98767173
ENST00000351193ENST00000427112NMD3chr3160953000+USP40chr2234407258-0.0110066870.98899335
ENST00000472947ENST00000450966NMD3chr3160953000+USP40chr2234407258-0.0121941960.98780584
ENST00000472947ENST00000251722NMD3chr3160953000+USP40chr2234407258-0.0119731020.98802686
ENST00000472947ENST00000427112NMD3chr3160953000+USP40chr2234407258-0.010544160.9894559
ENST00000460469ENST00000450966NMD3chr3160953000+USP40chr2234407258-0.0081960110.991804
ENST00000460469ENST00000251722NMD3chr3160953000+USP40chr2234407258-0.0081052120.9918948
ENST00000460469ENST00000427112NMD3chr3160953000+USP40chr2234407258-0.0059613910.9940386

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Fusion Genomic Features for NMD3-USP40


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NMD3-USP40


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:160953000/chr2:234407258)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NMD3

Q96D46

.
FUNCTION: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. {ECO:0000269|PubMed:12724356, ECO:0000269|PubMed:12773398}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNMD3chr3:160953000chr2:234407258ENST00000351193+716405_422192504.0MotifNote=Nuclear and nucleolar localization signal
HgeneNMD3chr3:160953000chr2:234407258ENST00000351193+716480_489192504.0MotifNote=Nuclear export signal
HgeneNMD3chr3:160953000chr2:234407258ENST00000460469+615405_422192504.0MotifNote=Nuclear and nucleolar localization signal
HgeneNMD3chr3:160953000chr2:234407258ENST00000460469+615480_489192504.0MotifNote=Nuclear export signal
HgeneNMD3chr3:160953000chr2:234407258ENST00000351193+716425_503192504.0RegionNote=Necessary for the nuclear export of the 60S ribosomal subunit
HgeneNMD3chr3:160953000chr2:234407258ENST00000460469+615425_503192504.0RegionNote=Necessary for the nuclear export of the 60S ribosomal subunit
TgeneUSP40chr3:160953000chr2:234407258ENST00000251722213241_4828821236.0DomainNote=USP
TgeneUSP40chr3:160953000chr2:234407258ENST000004099452641_48258164.0DomainNote=USP
TgeneUSP40chr3:160953000chr2:234407258ENST00000427112203141_4828821236.0DomainNote=USP
TgeneUSP40chr3:160953000chr2:234407258ENST00000450966203141_4828941248.0DomainNote=USP


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Fusion Gene Sequence for NMD3-USP40


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>59403_59403_1_NMD3-USP40_NMD3_chr3_160953000_ENST00000351193_USP40_chr2_234407258_ENST00000251722_length(transcript)=3644nt_BP=717nt
GCATTTCGCTCGCGAGATCTTCTCTGTGGCGGAGACAGCCAGGTTGGCAGCTGACGGGACAGCCGGGGTCTATTTTGTTGCGGGTTTTCA
GCAAATCCAGGGCTGGTCTGGAGGCGCGAAAACTTAAGGCATACAGAACGATGGAGTATATGGCAGAATCCACCGACCGCAGCCCTGGAC
ACATCTTGTGCTGTGAGTGTGGTGTTCCGATAAGTCCAAATCCTGCCAATATTTGTGTGGCCTGTTTGCGAAGTAAAGTGGACATCAGCC
AAGGTATTCCGAAACAAGTCTCGATTTCGTTCTGCAAACAATGTCAAAGGTATTTTCAACCACCAGGAACTTGGATACAGTGTGCTTTAG
AATCCAGGGAACTTCTTGCTTTGTGCTTGAAAAAAATCAAAGCCCCTCTGAGTAAGGTACGGCTTGTAGATGCAGGCTTTGTTTGGACTG
AGCCTCATTCTAAGAGACTTAAAGTTAAACTGACTATTCAGAAAGAGGTGATGAATGGTGCTATCCTTCAACAAGTGTTTGTGGTGGATT
ATGTTGTTCAGTCCCAAATGTGTGGAGATTGCCATAGAGTAGAAGCTAAGGATTTCTGGAAGGCTGTGATTCAAGTGAGGCAAAAGACTT
TGCATAAAAAAACTTTCTACTATCTGGAACAGTTAATTCTGAAATATGGAATGCATCAGAATACACTTCGTATCAAAGAGATTCATGGAG
ATGCCTGGCATTTACGAAAAATGGATTGGTGCTATGAAGCTGGAGAGCCTTTATGTGAAGAAGATGCAACACTGAAAGAACTTCTGATAT
GTTCTGGAGATACTTTGCTTTTAATTGAAGGACAACTTCCTCCTCTGGGTTTCCTGAAGGTGCCCATCTGGTGGTACCAGCTTCAGGGTC
CCTCAGGACACTGGGAGAGTCATCAGGACCAGACCAACTGTACTTCGTCTTGGGGCAGAGTTTGGAGAGCCACTTCCAGCCAAGGTGCTT
CTGGGAACGAGCCTGCGCAAGTTTCTCTCCTCTACTTGGGAGACATAGAGATCTCAGAAGATGCCACGCTGGCGGAGCTGAAGTCTCAGG
CCATGACCTTGCCTCCTTTCCTGGAGTTCGGTGTCCCGTCCCCAGCCCACCTCAGAGCCTGGACGGTGGAGAGGAAGCGCCCAGGCAGGC
TTTTACGAACTGACCGGCAGCCACTCAGGGAATATAAACTAGGACGGAGAATTGAGATCTGCTTAGAGCCCCTTCAGAAAGGCGAAAACT
TGGGCCCCCAGGACGTGCTGCTGAGGACACAGGTGCGCATCCCTGGTGAGAGGACCTATGCCCCTGCCCTGGACCTGGTGTGGAACGCGG
CCCAGGGTGGGACTGCCGGCTCCCTGAGGCAGAGAGTTGCCGATTTCTATCGTCTTCCCGTGGAGAAGATTGAAATTGCCAAATACTTTC
CCGAAAAGTTCGAGTGGCTTCCGATATCTAGCTGGAACCAACAAATAACCAAGAGGAAAAAGAAAAAAAAACAAGATTATTTGCAAGGGG
CACCGTATTACTTGAAAGACGGAGATACTATTGGTGTTAAGAATCTCCTGATTGACGACGATGATGATTTCAGTACAATCAGAGATGACA
CTGGAAAAGAAAAGCAGAAACAACGGGCCCTGGGGAGAAGGAAAAGCCAAGAAGCCCTCCATGAGCAGAGCAGCTACATCCTCTCCAGTG
CAGAGACGCCTGCCCGGCCCCGAGCCCCGGAAACTTCTCTCTCCATCCACGTGGGGAGCTTCAGATAACCGCGCCGCTGCACGGCTCTAC
TCCCGATGAACTCTCCGGCTGATGCCACAAACGTGGGTTTCCTGGGCATGGGGACTGGCTGCCTGGCGCCTCCAATCCCAAATCCTCTGC
TTCCTTTGAGCACAGGGACGGCTCCTCTGAGGCCTGGCCAGTGCATGTAGTCACTTAGCTCTGCAACACGTGGCAGCCACGGGGGCTGGT
GCAGCTCTGGATGTCGCCCACCCAGCTGCCAGTAGGTGCTGGGCTCTCTCACACAGCACCCGGCCCCAGCTGCCTTTTTTTTTCTTTTAA
CCAGAAAATGCACAACGTGTGCGTGAACCGCAGGTATGGAGGCAGCGGCATGCCGTTGCTCCGCTGTGGGAGGTGTGTGGGGTCAGGCCA
GCCACTTTCCTCCGTGTTCAGATGACTCTCGTTCGCCCTGACCGGCTTCTCACAGTGTCTCAGGCCACTGCGCCACCGCGCTGGTGCTGA
GCAGAAGCGGGCAGAAGTGGGGTCTGCTTTCAGGACTTCATTTCCCCCACTCGTTCCGGCCCCGCATGCTCCACGTCTGCCCTTTGGTCT
GAGTTAAAACTGCGATGCTGAAAAGTGCGAGCTCTTTCCACGAGGAGGAGCCACACAGGGTGGCCTCCGAGGGTGAGTCGCTCTGCTAAG
CAAGGGCAGCCGCTGCACGTCAGCCCGCAGGCCAAGGGTCCAGCTTATCCTGGGTGCTCTGTGATCAGAAGGTCCTTGGATCCCGAGGAC
TGCAGCTGCTGCCGTCCACAGCGCCTCAGCCTCTCTTCCTGTGTGGAAGCGGGGCAGGCAGGGCTGTGGCAGACAGGCCTGGCATAGCCC
AGGTTCCAGGTGTCCTGGGCAGCCTGACCGGTTTCCTGAGTAGCCTCAATGAAAACACCTGAGAAAAAGAAAATGTAAACTAAGGAAGGG
TTTTCCCACTTAATCCAACCCAGATTTCTATTCAACTTAAAGGATTTAATTGGCATTTGTGAGAAATAATAGTACCTGTGTCACTGAGTT
GATTGATTTGGGACATAGACGGTTGACTTTCCCAGACAGCAGCTTAGCGGAAAGCAGCATCCCGAAGACGGTGTCGCATGTCCTGAGCCT
GCTTGTCACCTGGGCCTCACGGTTTCTCGTCAGCCCCGTCACTGATGGGAAGCAGCACTGAAGTGTGAGGGCAGAAAGGACACCGCTGGA
GTCAGGCGCTCCCCTGCCTGTGACCCTTTTCCAACAAGCTGATGCTGAGCCAGCGGCCTGCTTTGTCCCTCATACTCCTCCCAACAGTCC
AAACCCCTACCAGACAGAAGCCACGTCGCTTCTGCACACGTGTCTGAGAGCGTCTGCCATAGACGTCTGTGCGTTTCCGTGAAGCACTGC
GCCCTAAGGACCCAACTCTGACTAGCAGCTGCCTCCCACTCCCAAACACTAACCCCGCTCAGGAGACTCGCACTGGGTGTAGACTGCGTC
TTTGCAGAGGGAGATGATAGAGGCTTCTGATGACGCCAGAGCTGTAAGTGTCGTGACGAGCTGGGCGCCCAGCCCTTCTTAAGCTGTTCT
GTTTCTGTGGCTTTAACTGACATATTTCTGTAGCATCTGCCTTCATCTCATCTCAGCGTAATGAAATATTAATGAAATCGCTGAAAAGCT
TTGCCTTCGAGAGGCCAGAAGCCTCGCGGAATGTCTGCAAGTCCAAAGACGCGTGTGGGTTGTGCCCTGAAGTGCCGTCCAGCAGGCGCG
TGCGGCCGGGCCGGCCTGTGCGTGTGGCCTTTGCCTTCTTCCCTTTCTTCCTGTTTTCTGTTTTTTTAATTTGGGGATTGAGAAAGCTGT

>59403_59403_1_NMD3-USP40_NMD3_chr3_160953000_ENST00000351193_USP40_chr2_234407258_ENST00000251722_length(amino acids)=584AA_BP=231
MWRRQPGWQLTGQPGSILLRVFSKSRAGLEARKLKAYRTMEYMAESTDRSPGHILCCECGVPISPNPANICVACLRSKVDISQGIPKQVS
ISFCKQCQRYFQPPGTWIQCALESRELLALCLKKIKAPLSKVRLVDAGFVWTEPHSKRLKVKLTIQKEVMNGAILQQVFVVDYVVQSQMC
GDCHRVEAKDFWKAVIQVRQKTLHKKTFYYLEQLILKYGMHQNTLRIKEIHGDAWHLRKMDWCYEAGEPLCEEDATLKELLICSGDTLLL
IEGQLPPLGFLKVPIWWYQLQGPSGHWESHQDQTNCTSSWGRVWRATSSQGASGNEPAQVSLLYLGDIEISEDATLAELKSQAMTLPPFL
EFGVPSPAHLRAWTVERKRPGRLLRTDRQPLREYKLGRRIEICLEPLQKGENLGPQDVLLRTQVRIPGERTYAPALDLVWNAAQGGTAGS
LRQRVADFYRLPVEKIEIAKYFPEKFEWLPISSWNQQITKRKKKKKQDYLQGAPYYLKDGDTIGVKNLLIDDDDDFSTIRDDTGKEKQKQ

--------------------------------------------------------------
>59403_59403_2_NMD3-USP40_NMD3_chr3_160953000_ENST00000351193_USP40_chr2_234407258_ENST00000427112_length(transcript)=1778nt_BP=717nt
GCATTTCGCTCGCGAGATCTTCTCTGTGGCGGAGACAGCCAGGTTGGCAGCTGACGGGACAGCCGGGGTCTATTTTGTTGCGGGTTTTCA
GCAAATCCAGGGCTGGTCTGGAGGCGCGAAAACTTAAGGCATACAGAACGATGGAGTATATGGCAGAATCCACCGACCGCAGCCCTGGAC
ACATCTTGTGCTGTGAGTGTGGTGTTCCGATAAGTCCAAATCCTGCCAATATTTGTGTGGCCTGTTTGCGAAGTAAAGTGGACATCAGCC
AAGGTATTCCGAAACAAGTCTCGATTTCGTTCTGCAAACAATGTCAAAGGTATTTTCAACCACCAGGAACTTGGATACAGTGTGCTTTAG
AATCCAGGGAACTTCTTGCTTTGTGCTTGAAAAAAATCAAAGCCCCTCTGAGTAAGGTACGGCTTGTAGATGCAGGCTTTGTTTGGACTG
AGCCTCATTCTAAGAGACTTAAAGTTAAACTGACTATTCAGAAAGAGGTGATGAATGGTGCTATCCTTCAACAAGTGTTTGTGGTGGATT
ATGTTGTTCAGTCCCAAATGTGTGGAGATTGCCATAGAGTAGAAGCTAAGGATTTCTGGAAGGCTGTGATTCAAGTGAGGCAAAAGACTT
TGCATAAAAAAACTTTCTACTATCTGGAACAGTTAATTCTGAAATATGGAATGCATCAGAATACACTTCGTATCAAAGAGATTCATGGAG
ATGCCTGGCATTTACGAAAAATGGATTGGTGCTATGAAGCTGGAGAGCCTTTATGTGAAGAAGATGCAACACTGAAAGAACTTCTGATAT
GTTCTGGAGATACTTTGCTTTTAATTGAAGGACAACTTCCTCCTCTGGGTTTCCTGAAGGTGCCCATCTGGTGGTACCAGCTTCAGGGTC
CCTCAGGACACTGGGAGAGTCATCAGGACCAGACCAACTGTACTTCGTCTTGGGGCAGAGTTTGGAGAGCCACTTCCAGCCAAGGTGCTT
CTGGGAACGAGCCTGCGCAAGTTTCTCTCCTCTACTTGGGAGACATAGAGATCTCAGAAGATGCCACGCTGGCGGAGCTGAAGTCTCAGG
CCATGACCTTGCCTCCTTTCCTGGAGTTCGGTGTCCCGTCCCCAGCCCACCTCAGAGCCTGGACGGTGGAGAGGAAGCGCCCAGGCAGGC
TTTTACGAACTGACCGGCAGCCACTCAGGGAATATAAACTAGGACGGAGAATTGAGATCTGCTTAGAGCCCCTTCAGAAAGGCGAAAACT
TGGGCCCCCAGGACGTGCTGCTGAGGACACAGGTGCGCATCCCTGGTGAGAGGACCTATGCCCCTGCCCTGGACCTGGTGTGGAACGCGG
CCCAGGGTGGGACTGCCGGCTCCCTGAGGCAGAGAGTTGCCGATTTCTATCGTCTTCCCGTGGAGAAGATTGAAATTGCCAAATACTTTC
CCGAAAAGTTCGAGTGGCTTCCGATATCTAGCTGGAACCAACAAATAACCAAGAGGAAAAAGAAAAAAAAACAAGATTATTTGCAAGGGG
CACCGTATTACTTGAAAGACGGAGATACTATTGGTGTTAAGAATCTCCTGATTGACGACGATGATGATTTCAGTACAATCAGAGATGACA
CTGGAAAAGAAAAGCAGAAACAACGGGCCCTGGGGAGAAGGAAAAGCCAAGAAGCCCTCCATGAGCAGAGCAGCTACATCCTCTCCAGTG

>59403_59403_2_NMD3-USP40_NMD3_chr3_160953000_ENST00000351193_USP40_chr2_234407258_ENST00000427112_length(amino acids)=585AA_BP=231
MWRRQPGWQLTGQPGSILLRVFSKSRAGLEARKLKAYRTMEYMAESTDRSPGHILCCECGVPISPNPANICVACLRSKVDISQGIPKQVS
ISFCKQCQRYFQPPGTWIQCALESRELLALCLKKIKAPLSKVRLVDAGFVWTEPHSKRLKVKLTIQKEVMNGAILQQVFVVDYVVQSQMC
GDCHRVEAKDFWKAVIQVRQKTLHKKTFYYLEQLILKYGMHQNTLRIKEIHGDAWHLRKMDWCYEAGEPLCEEDATLKELLICSGDTLLL
IEGQLPPLGFLKVPIWWYQLQGPSGHWESHQDQTNCTSSWGRVWRATSSQGASGNEPAQVSLLYLGDIEISEDATLAELKSQAMTLPPFL
EFGVPSPAHLRAWTVERKRPGRLLRTDRQPLREYKLGRRIEICLEPLQKGENLGPQDVLLRTQVRIPGERTYAPALDLVWNAAQGGTAGS
LRQRVADFYRLPVEKIEIAKYFPEKFEWLPISSWNQQITKRKKKKKQDYLQGAPYYLKDGDTIGVKNLLIDDDDDFSTIRDDTGKEKQKQ

--------------------------------------------------------------
>59403_59403_3_NMD3-USP40_NMD3_chr3_160953000_ENST00000351193_USP40_chr2_234407258_ENST00000450966_length(transcript)=3650nt_BP=717nt
GCATTTCGCTCGCGAGATCTTCTCTGTGGCGGAGACAGCCAGGTTGGCAGCTGACGGGACAGCCGGGGTCTATTTTGTTGCGGGTTTTCA
GCAAATCCAGGGCTGGTCTGGAGGCGCGAAAACTTAAGGCATACAGAACGATGGAGTATATGGCAGAATCCACCGACCGCAGCCCTGGAC
ACATCTTGTGCTGTGAGTGTGGTGTTCCGATAAGTCCAAATCCTGCCAATATTTGTGTGGCCTGTTTGCGAAGTAAAGTGGACATCAGCC
AAGGTATTCCGAAACAAGTCTCGATTTCGTTCTGCAAACAATGTCAAAGGTATTTTCAACCACCAGGAACTTGGATACAGTGTGCTTTAG
AATCCAGGGAACTTCTTGCTTTGTGCTTGAAAAAAATCAAAGCCCCTCTGAGTAAGGTACGGCTTGTAGATGCAGGCTTTGTTTGGACTG
AGCCTCATTCTAAGAGACTTAAAGTTAAACTGACTATTCAGAAAGAGGTGATGAATGGTGCTATCCTTCAACAAGTGTTTGTGGTGGATT
ATGTTGTTCAGTCCCAAATGTGTGGAGATTGCCATAGAGTAGAAGCTAAGGATTTCTGGAAGGCTGTGATTCAAGTGAGGCAAAAGACTT
TGCATAAAAAAACTTTCTACTATCTGGAACAGTTAATTCTGAAATATGGAATGCATCAGAATACACTTCGTATCAAAGAGATTCATGGAG
ATGCCTGGCATTTACGAAAAATGGATTGGTGCTATGAAGCTGGAGAGCCTTTATGTGAAGAAGATGCAACACTGAAAGAACTTCTGATAT
GTTCTGGAGATACTTTGCTTTTAATTGAAGGACAACTTCCTCCTCTGGGTTTCCTGAAGGTGCCCATCTGGTGGTACCAGCTTCAGGGTC
CCTCAGGACACTGGGAGAGTCATCAGGACCAGACCAACTGTACTTCGTCTTGGGGCAGAGTTTGGAGAGCCACTTCCAGCCAAGGTGCTT
CTGGGAACGAGCCTGCGCAAGTTTCTCTCCTCTACTTGGGAGACATAGAGATCTCAGAAGATGCCACGCTGGCGGAGCTGAAGTCTCAGG
CCATGACCTTGCCTCCTTTCCTGGAGTTCGGTGTCCCGTCCCCAGCCCACCTCAGAGCCTGGACGGTGGAGAGGAAGCGCCCAGGCAGGC
TTTTACGAACTGACCGGCAGCCACTCAGGGAATATAAACTAGGACGGAGAATTGAGATCTGCTTAGAGCCCCTTCAGAAAGGCGAAAACT
TGGGCCCCCAGGACGTGCTGCTGAGGACACAGGTGCGCATCCCTGGTGAGAGGACCTATGCCCCTGCCCTGGACCTGGTGTGGAACGCGG
CCCAGGGTGGGACTGCCGGCTCCCTGAGGCAGAGAGTTGCCGATTTCTATCGTCTTCCCGTGGAGAAGATTGAAATTGCCAAATACTTTC
CCGAAAAGTTCGAGTGGCTTCCGATATCTAGCTGGAACCAACAAATAACCAAGAGGAAAAAGAAAAAAAAACAAGATTATTTGCAAGGGG
CACCGTATTACTTGAAAGACGGAGATACTATTGGTGTTAAGAATCTCCTGATTGACGACGATGATGATTTCAGTACAATCAGAGATGACA
CTGGAAAAGAAAAGCAGAAACAACGGGCCCTGGGGAGAAGGAAAAGCCAAGAAGCCCTCCATGAGCAGAGCAGCTACATCCTCTCCAGTG
CAGAGACGCCTGCCCGGCCCCGAGCCCCGGAAACTTCTCTCTCCATCCACGTGGGGAGCTTCAGATAACCGCGCCGCTGCACGGCTCTAC
TCCCGATGAACTCTCCGGCTGATGCCACAAACGTGGGTTTCCTGGGCATGGGGACTGGCTGCCTGGCGCCTCCAATCCCAAATCCTCTGC
TTCCTTTGAGCACAGGGACGGCTCCTCTGAGGCCTGGCCAGTGCATGTAGTCACTTAGCTCTGCAACACGTGGCAGCCACGGGGGCTGGT
GCAGCTCTGGATGTCGCCCACCCAGCTGCCAGTAGGTGCTGGGCTCTCTCACACAGCACCCGGCCCCAGCTGCCTTTTTTTTTCTTTTAA
CCAGAAAATGCACAACGTGTGCGTGAACCGCAGGTATGGAGGCAGCGGCATGCCGTTGCTCCGCTGTGGGAGGTGTGTGGGGTCAGGCCA
GCCACTTTCCTCCGTGTTCAGATGACTCTCGTTCGCCCTGACCGGCTTCTCACAGTGTCTCAGGCCACTGCGCCACCGCGCTGGTGCTGA
GCAGAAGCGGGCAGAAGTGGGGTCTGCTTTCAGGACTTCATTTCCCCCACTCGTTCCGGCCCCGCATGCTCCACGTCTGCCCTTTGGTCT
GAGTTAAAACTGCGATGCTGAAAAGTGCGAGCTCTTTCCACGAGGAGGAGCCACACAGGGTGGCCTCCGAGGGTGAGTCGCTCTGCTAAG
CAAGGGCAGCCGCTGCACGTCAGCCCGCAGGCCAAGGGTCCAGCTTATCCTGGGTGCTCTGTGATCAGAAGGTCCTTGGATCCCGAGGAC
TGCAGCTGCTGCCGTCCACAGCGCCTCAGCCTCTCTTCCTGTGTGGAAGCGGGGCAGGCAGGGCTGTGGCAGACAGGCCTGGCATAGCCC
AGGTTCCAGGTGTCCTGGGCAGCCTGACCGGTTTCCTGAGTAGCCTCAATGAAAACACCTGAGAAAAAGAAAATGTAAACTAAGGAAGGG
TTTTCCCACTTAATCCAACCCAGATTTCTATTCAACTTAAAGGATTTAATTGGCATTTGTGAGAAATAATAGTACCTGTGTCACTGAGTT
GATTGATTTGGGACATAGACGGTTGACTTTCCCAGACAGCAGCTTAGCGGAAAGCAGCATCCCGAAGACGGTGTCGCATGTCCTGAGCCT
GCTTGTCACCTGGGCCTCACGGTTTCTCGTCAGCCCCGTCACTGATGGGAAGCAGCACTGAAGTGTGAGGGCAGAAAGGACACCGCTGGA
GTCAGGCGCTCCCCTGCCTGTGACCCTTTTCCAACAAGCTGATGCTGAGCCAGCGGCCTGCTTTGTCCCTCATACTCCTCCCAACAGTCC
AAACCCCTACCAGACAGAAGCCACGTCGCTTCTGCACACGTGTCTGAGAGCGTCTGCCATAGACGTCTGTGCGTTTCCGTGAAGCACTGC
GCCCTAAGGACCCAACTCTGACTAGCAGCTGCCTCCCACTCCCAAACACTAACCCCGCTCAGGAGACTCGCACTGGGTGTAGACTGCGTC
TTTGCAGAGGGAGATGATAGAGGCTTCTGATGACGCCAGAGCTGTAAGTGTCGTGACGAGCTGGGCGCCCAGCCCTTCTTAAGCTGTTCT
GTTTCTGTGGCTTTAACTGACATATTTCTGTAGCATCTGCCTTCATCTCATCTCAGCGTAATGAAATATTAATGAAATCGCTGAAAAGCT
TTGCCTTCGAGAGGCCAGAAGCCTCGCGGAATGTCTGCAAGTCCAAAGACGCGTGTGGGTTGTGCCCTGAAGTGCCGTCCAGCAGGCGCG
TGCGGCCGGGCCGGCCTGTGCGTGTGGCCTTTGCCTTCTTCCCTTTCTTCCTGTTTTCTGTTTTTTTAATTTGGGGATTGAGAAAGCTGT

>59403_59403_3_NMD3-USP40_NMD3_chr3_160953000_ENST00000351193_USP40_chr2_234407258_ENST00000450966_length(amino acids)=584AA_BP=231
MWRRQPGWQLTGQPGSILLRVFSKSRAGLEARKLKAYRTMEYMAESTDRSPGHILCCECGVPISPNPANICVACLRSKVDISQGIPKQVS
ISFCKQCQRYFQPPGTWIQCALESRELLALCLKKIKAPLSKVRLVDAGFVWTEPHSKRLKVKLTIQKEVMNGAILQQVFVVDYVVQSQMC
GDCHRVEAKDFWKAVIQVRQKTLHKKTFYYLEQLILKYGMHQNTLRIKEIHGDAWHLRKMDWCYEAGEPLCEEDATLKELLICSGDTLLL
IEGQLPPLGFLKVPIWWYQLQGPSGHWESHQDQTNCTSSWGRVWRATSSQGASGNEPAQVSLLYLGDIEISEDATLAELKSQAMTLPPFL
EFGVPSPAHLRAWTVERKRPGRLLRTDRQPLREYKLGRRIEICLEPLQKGENLGPQDVLLRTQVRIPGERTYAPALDLVWNAAQGGTAGS
LRQRVADFYRLPVEKIEIAKYFPEKFEWLPISSWNQQITKRKKKKKQDYLQGAPYYLKDGDTIGVKNLLIDDDDDFSTIRDDTGKEKQKQ

--------------------------------------------------------------
>59403_59403_4_NMD3-USP40_NMD3_chr3_160953000_ENST00000460469_USP40_chr2_234407258_ENST00000251722_length(transcript)=3959nt_BP=1032nt
GGCGTGGGTGGCCCTCGGGCGCCGGGACGCCGTCCGGAGACTCCTGTGGCGTGGGTCTGAGGCGCGGTGGTCCGGTGCGGTCCCTGGGCT
GGTGGAGAGCGGGAGGGCCCGGGCGTCCACAATCCCGAGCTGACCTCGCCCTTGGTCGTCCAGGGTTGGAGCCCAGGTGAGATGGAGGTC
AGCGGCAGAGCTGGGTGGCCCGAGGGTCTTGCAGCTGGGAAGCTCAGGAAATCCCATGGTCCTCATCTTAAAGTTCTTTTTAACGAACTT
ACCCAGTGGAGTTGGGTTTCCTTCTTTCCTGCTTTTTCGAAGTTCTGTGAATATATTAATTATTCAGAGAGACTGGAGGAAGACGTAAAA
AGAGGAGACTAGGTAAAGTGATTTAAATCCCAACATTCTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTAAAAGAACTTAAGGCATACA
GAACGATGGAGTATATGGCAGAATCCACCGACCGCAGCCCTGGACACATCTTGTGCTGTGAGTGTGGTGTTCCGATAAGTCCAAATCCTG
CCAATATTTGTGTGGCCTGTTTGCGAAGTAAAGTGGACATCAGCCAAGGTATTCCGAAACAAGTCTCGATTTCGTTCTGCAAACAATGTC
AAAGGTATTTTCAACCACCAGGAACTTGGATACAGTGTGCTTTAGAATCCAGGGAACTTCTTGCTTTGTGCTTGAAAAAAATCAAAGCCC
CTCTGAGTAAGGTACGGCTTGTAGATGCAGGCTTTGTTTGGACTGAGCCTCATTCTAAGAGACTTAAAGTTAAACTGACTATTCAGAAAG
AGGTGATGAATGGTGCTATCCTTCAACAAGTGTTTGTGGTGGATTATGTTGTTCAGTCCCAAATGTGTGGAGATTGCCATAGAGTAGAAG
CTAAGGATTTCTGGAAGGCTGTGATTCAAGTGAGGCAAAAGACTTTGCATAAAAAAACTTTCTACTATCTGGAACAGTTAATTCTGAAAT
ATGGAATGCATCAGAATACACTTCGTATCAAAGAGATTCATGGAGATGCCTGGCATTTACGAAAAATGGATTGGTGCTATGAAGCTGGAG
AGCCTTTATGTGAAGAAGATGCAACACTGAAAGAACTTCTGATATGTTCTGGAGATACTTTGCTTTTAATTGAAGGACAACTTCCTCCTC
TGGGTTTCCTGAAGGTGCCCATCTGGTGGTACCAGCTTCAGGGTCCCTCAGGACACTGGGAGAGTCATCAGGACCAGACCAACTGTACTT
CGTCTTGGGGCAGAGTTTGGAGAGCCACTTCCAGCCAAGGTGCTTCTGGGAACGAGCCTGCGCAAGTTTCTCTCCTCTACTTGGGAGACA
TAGAGATCTCAGAAGATGCCACGCTGGCGGAGCTGAAGTCTCAGGCCATGACCTTGCCTCCTTTCCTGGAGTTCGGTGTCCCGTCCCCAG
CCCACCTCAGAGCCTGGACGGTGGAGAGGAAGCGCCCAGGCAGGCTTTTACGAACTGACCGGCAGCCACTCAGGGAATATAAACTAGGAC
GGAGAATTGAGATCTGCTTAGAGCCCCTTCAGAAAGGCGAAAACTTGGGCCCCCAGGACGTGCTGCTGAGGACACAGGTGCGCATCCCTG
GTGAGAGGACCTATGCCCCTGCCCTGGACCTGGTGTGGAACGCGGCCCAGGGTGGGACTGCCGGCTCCCTGAGGCAGAGAGTTGCCGATT
TCTATCGTCTTCCCGTGGAGAAGATTGAAATTGCCAAATACTTTCCCGAAAAGTTCGAGTGGCTTCCGATATCTAGCTGGAACCAACAAA
TAACCAAGAGGAAAAAGAAAAAAAAACAAGATTATTTGCAAGGGGCACCGTATTACTTGAAAGACGGAGATACTATTGGTGTTAAGAATC
TCCTGATTGACGACGATGATGATTTCAGTACAATCAGAGATGACACTGGAAAAGAAAAGCAGAAACAACGGGCCCTGGGGAGAAGGAAAA
GCCAAGAAGCCCTCCATGAGCAGAGCAGCTACATCCTCTCCAGTGCAGAGACGCCTGCCCGGCCCCGAGCCCCGGAAACTTCTCTCTCCA
TCCACGTGGGGAGCTTCAGATAACCGCGCCGCTGCACGGCTCTACTCCCGATGAACTCTCCGGCTGATGCCACAAACGTGGGTTTCCTGG
GCATGGGGACTGGCTGCCTGGCGCCTCCAATCCCAAATCCTCTGCTTCCTTTGAGCACAGGGACGGCTCCTCTGAGGCCTGGCCAGTGCA
TGTAGTCACTTAGCTCTGCAACACGTGGCAGCCACGGGGGCTGGTGCAGCTCTGGATGTCGCCCACCCAGCTGCCAGTAGGTGCTGGGCT
CTCTCACACAGCACCCGGCCCCAGCTGCCTTTTTTTTTCTTTTAACCAGAAAATGCACAACGTGTGCGTGAACCGCAGGTATGGAGGCAG
CGGCATGCCGTTGCTCCGCTGTGGGAGGTGTGTGGGGTCAGGCCAGCCACTTTCCTCCGTGTTCAGATGACTCTCGTTCGCCCTGACCGG
CTTCTCACAGTGTCTCAGGCCACTGCGCCACCGCGCTGGTGCTGAGCAGAAGCGGGCAGAAGTGGGGTCTGCTTTCAGGACTTCATTTCC
CCCACTCGTTCCGGCCCCGCATGCTCCACGTCTGCCCTTTGGTCTGAGTTAAAACTGCGATGCTGAAAAGTGCGAGCTCTTTCCACGAGG
AGGAGCCACACAGGGTGGCCTCCGAGGGTGAGTCGCTCTGCTAAGCAAGGGCAGCCGCTGCACGTCAGCCCGCAGGCCAAGGGTCCAGCT
TATCCTGGGTGCTCTGTGATCAGAAGGTCCTTGGATCCCGAGGACTGCAGCTGCTGCCGTCCACAGCGCCTCAGCCTCTCTTCCTGTGTG
GAAGCGGGGCAGGCAGGGCTGTGGCAGACAGGCCTGGCATAGCCCAGGTTCCAGGTGTCCTGGGCAGCCTGACCGGTTTCCTGAGTAGCC
TCAATGAAAACACCTGAGAAAAAGAAAATGTAAACTAAGGAAGGGTTTTCCCACTTAATCCAACCCAGATTTCTATTCAACTTAAAGGAT
TTAATTGGCATTTGTGAGAAATAATAGTACCTGTGTCACTGAGTTGATTGATTTGGGACATAGACGGTTGACTTTCCCAGACAGCAGCTT
AGCGGAAAGCAGCATCCCGAAGACGGTGTCGCATGTCCTGAGCCTGCTTGTCACCTGGGCCTCACGGTTTCTCGTCAGCCCCGTCACTGA
TGGGAAGCAGCACTGAAGTGTGAGGGCAGAAAGGACACCGCTGGAGTCAGGCGCTCCCCTGCCTGTGACCCTTTTCCAACAAGCTGATGC
TGAGCCAGCGGCCTGCTTTGTCCCTCATACTCCTCCCAACAGTCCAAACCCCTACCAGACAGAAGCCACGTCGCTTCTGCACACGTGTCT
GAGAGCGTCTGCCATAGACGTCTGTGCGTTTCCGTGAAGCACTGCGCCCTAAGGACCCAACTCTGACTAGCAGCTGCCTCCCACTCCCAA
ACACTAACCCCGCTCAGGAGACTCGCACTGGGTGTAGACTGCGTCTTTGCAGAGGGAGATGATAGAGGCTTCTGATGACGCCAGAGCTGT
AAGTGTCGTGACGAGCTGGGCGCCCAGCCCTTCTTAAGCTGTTCTGTTTCTGTGGCTTTAACTGACATATTTCTGTAGCATCTGCCTTCA
TCTCATCTCAGCGTAATGAAATATTAATGAAATCGCTGAAAAGCTTTGCCTTCGAGAGGCCAGAAGCCTCGCGGAATGTCTGCAAGTCCA
AAGACGCGTGTGGGTTGTGCCCTGAAGTGCCGTCCAGCAGGCGCGTGCGGCCGGGCCGGCCTGTGCGTGTGGCCTTTGCCTTCTTCCCTT

>59403_59403_4_NMD3-USP40_NMD3_chr3_160953000_ENST00000460469_USP40_chr2_234407258_ENST00000251722_length(amino acids)=545AA_BP=192
MEYMAESTDRSPGHILCCECGVPISPNPANICVACLRSKVDISQGIPKQVSISFCKQCQRYFQPPGTWIQCALESRELLALCLKKIKAPL
SKVRLVDAGFVWTEPHSKRLKVKLTIQKEVMNGAILQQVFVVDYVVQSQMCGDCHRVEAKDFWKAVIQVRQKTLHKKTFYYLEQLILKYG
MHQNTLRIKEIHGDAWHLRKMDWCYEAGEPLCEEDATLKELLICSGDTLLLIEGQLPPLGFLKVPIWWYQLQGPSGHWESHQDQTNCTSS
WGRVWRATSSQGASGNEPAQVSLLYLGDIEISEDATLAELKSQAMTLPPFLEFGVPSPAHLRAWTVERKRPGRLLRTDRQPLREYKLGRR
IEICLEPLQKGENLGPQDVLLRTQVRIPGERTYAPALDLVWNAAQGGTAGSLRQRVADFYRLPVEKIEIAKYFPEKFEWLPISSWNQQIT
KRKKKKKQDYLQGAPYYLKDGDTIGVKNLLIDDDDDFSTIRDDTGKEKQKQRALGRRKSQEALHEQSSYILSSAETPARPRAPETSLSIH

--------------------------------------------------------------
>59403_59403_5_NMD3-USP40_NMD3_chr3_160953000_ENST00000460469_USP40_chr2_234407258_ENST00000427112_length(transcript)=2093nt_BP=1032nt
GGCGTGGGTGGCCCTCGGGCGCCGGGACGCCGTCCGGAGACTCCTGTGGCGTGGGTCTGAGGCGCGGTGGTCCGGTGCGGTCCCTGGGCT
GGTGGAGAGCGGGAGGGCCCGGGCGTCCACAATCCCGAGCTGACCTCGCCCTTGGTCGTCCAGGGTTGGAGCCCAGGTGAGATGGAGGTC
AGCGGCAGAGCTGGGTGGCCCGAGGGTCTTGCAGCTGGGAAGCTCAGGAAATCCCATGGTCCTCATCTTAAAGTTCTTTTTAACGAACTT
ACCCAGTGGAGTTGGGTTTCCTTCTTTCCTGCTTTTTCGAAGTTCTGTGAATATATTAATTATTCAGAGAGACTGGAGGAAGACGTAAAA
AGAGGAGACTAGGTAAAGTGATTTAAATCCCAACATTCTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTAAAAGAACTTAAGGCATACA
GAACGATGGAGTATATGGCAGAATCCACCGACCGCAGCCCTGGACACATCTTGTGCTGTGAGTGTGGTGTTCCGATAAGTCCAAATCCTG
CCAATATTTGTGTGGCCTGTTTGCGAAGTAAAGTGGACATCAGCCAAGGTATTCCGAAACAAGTCTCGATTTCGTTCTGCAAACAATGTC
AAAGGTATTTTCAACCACCAGGAACTTGGATACAGTGTGCTTTAGAATCCAGGGAACTTCTTGCTTTGTGCTTGAAAAAAATCAAAGCCC
CTCTGAGTAAGGTACGGCTTGTAGATGCAGGCTTTGTTTGGACTGAGCCTCATTCTAAGAGACTTAAAGTTAAACTGACTATTCAGAAAG
AGGTGATGAATGGTGCTATCCTTCAACAAGTGTTTGTGGTGGATTATGTTGTTCAGTCCCAAATGTGTGGAGATTGCCATAGAGTAGAAG
CTAAGGATTTCTGGAAGGCTGTGATTCAAGTGAGGCAAAAGACTTTGCATAAAAAAACTTTCTACTATCTGGAACAGTTAATTCTGAAAT
ATGGAATGCATCAGAATACACTTCGTATCAAAGAGATTCATGGAGATGCCTGGCATTTACGAAAAATGGATTGGTGCTATGAAGCTGGAG
AGCCTTTATGTGAAGAAGATGCAACACTGAAAGAACTTCTGATATGTTCTGGAGATACTTTGCTTTTAATTGAAGGACAACTTCCTCCTC
TGGGTTTCCTGAAGGTGCCCATCTGGTGGTACCAGCTTCAGGGTCCCTCAGGACACTGGGAGAGTCATCAGGACCAGACCAACTGTACTT
CGTCTTGGGGCAGAGTTTGGAGAGCCACTTCCAGCCAAGGTGCTTCTGGGAACGAGCCTGCGCAAGTTTCTCTCCTCTACTTGGGAGACA
TAGAGATCTCAGAAGATGCCACGCTGGCGGAGCTGAAGTCTCAGGCCATGACCTTGCCTCCTTTCCTGGAGTTCGGTGTCCCGTCCCCAG
CCCACCTCAGAGCCTGGACGGTGGAGAGGAAGCGCCCAGGCAGGCTTTTACGAACTGACCGGCAGCCACTCAGGGAATATAAACTAGGAC
GGAGAATTGAGATCTGCTTAGAGCCCCTTCAGAAAGGCGAAAACTTGGGCCCCCAGGACGTGCTGCTGAGGACACAGGTGCGCATCCCTG
GTGAGAGGACCTATGCCCCTGCCCTGGACCTGGTGTGGAACGCGGCCCAGGGTGGGACTGCCGGCTCCCTGAGGCAGAGAGTTGCCGATT
TCTATCGTCTTCCCGTGGAGAAGATTGAAATTGCCAAATACTTTCCCGAAAAGTTCGAGTGGCTTCCGATATCTAGCTGGAACCAACAAA
TAACCAAGAGGAAAAAGAAAAAAAAACAAGATTATTTGCAAGGGGCACCGTATTACTTGAAAGACGGAGATACTATTGGTGTTAAGAATC
TCCTGATTGACGACGATGATGATTTCAGTACAATCAGAGATGACACTGGAAAAGAAAAGCAGAAACAACGGGCCCTGGGGAGAAGGAAAA
GCCAAGAAGCCCTCCATGAGCAGAGCAGCTACATCCTCTCCAGTGCAGAGACGCCTGCCCGGCCCCGAGCCCCGGAAACTTCTCTCTCCA

>59403_59403_5_NMD3-USP40_NMD3_chr3_160953000_ENST00000460469_USP40_chr2_234407258_ENST00000427112_length(amino acids)=546AA_BP=192
MEYMAESTDRSPGHILCCECGVPISPNPANICVACLRSKVDISQGIPKQVSISFCKQCQRYFQPPGTWIQCALESRELLALCLKKIKAPL
SKVRLVDAGFVWTEPHSKRLKVKLTIQKEVMNGAILQQVFVVDYVVQSQMCGDCHRVEAKDFWKAVIQVRQKTLHKKTFYYLEQLILKYG
MHQNTLRIKEIHGDAWHLRKMDWCYEAGEPLCEEDATLKELLICSGDTLLLIEGQLPPLGFLKVPIWWYQLQGPSGHWESHQDQTNCTSS
WGRVWRATSSQGASGNEPAQVSLLYLGDIEISEDATLAELKSQAMTLPPFLEFGVPSPAHLRAWTVERKRPGRLLRTDRQPLREYKLGRR
IEICLEPLQKGENLGPQDVLLRTQVRIPGERTYAPALDLVWNAAQGGTAGSLRQRVADFYRLPVEKIEIAKYFPEKFEWLPISSWNQQIT
KRKKKKKQDYLQGAPYYLKDGDTIGVKNLLIDDDDDFSTIRDDTGKEKQKQRALGRRKSQEALHEQSSYILSSAETPARPRAPETSLSIH

--------------------------------------------------------------
>59403_59403_6_NMD3-USP40_NMD3_chr3_160953000_ENST00000460469_USP40_chr2_234407258_ENST00000450966_length(transcript)=3965nt_BP=1032nt
GGCGTGGGTGGCCCTCGGGCGCCGGGACGCCGTCCGGAGACTCCTGTGGCGTGGGTCTGAGGCGCGGTGGTCCGGTGCGGTCCCTGGGCT
GGTGGAGAGCGGGAGGGCCCGGGCGTCCACAATCCCGAGCTGACCTCGCCCTTGGTCGTCCAGGGTTGGAGCCCAGGTGAGATGGAGGTC
AGCGGCAGAGCTGGGTGGCCCGAGGGTCTTGCAGCTGGGAAGCTCAGGAAATCCCATGGTCCTCATCTTAAAGTTCTTTTTAACGAACTT
ACCCAGTGGAGTTGGGTTTCCTTCTTTCCTGCTTTTTCGAAGTTCTGTGAATATATTAATTATTCAGAGAGACTGGAGGAAGACGTAAAA
AGAGGAGACTAGGTAAAGTGATTTAAATCCCAACATTCTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTAAAAGAACTTAAGGCATACA
GAACGATGGAGTATATGGCAGAATCCACCGACCGCAGCCCTGGACACATCTTGTGCTGTGAGTGTGGTGTTCCGATAAGTCCAAATCCTG
CCAATATTTGTGTGGCCTGTTTGCGAAGTAAAGTGGACATCAGCCAAGGTATTCCGAAACAAGTCTCGATTTCGTTCTGCAAACAATGTC
AAAGGTATTTTCAACCACCAGGAACTTGGATACAGTGTGCTTTAGAATCCAGGGAACTTCTTGCTTTGTGCTTGAAAAAAATCAAAGCCC
CTCTGAGTAAGGTACGGCTTGTAGATGCAGGCTTTGTTTGGACTGAGCCTCATTCTAAGAGACTTAAAGTTAAACTGACTATTCAGAAAG
AGGTGATGAATGGTGCTATCCTTCAACAAGTGTTTGTGGTGGATTATGTTGTTCAGTCCCAAATGTGTGGAGATTGCCATAGAGTAGAAG
CTAAGGATTTCTGGAAGGCTGTGATTCAAGTGAGGCAAAAGACTTTGCATAAAAAAACTTTCTACTATCTGGAACAGTTAATTCTGAAAT
ATGGAATGCATCAGAATACACTTCGTATCAAAGAGATTCATGGAGATGCCTGGCATTTACGAAAAATGGATTGGTGCTATGAAGCTGGAG
AGCCTTTATGTGAAGAAGATGCAACACTGAAAGAACTTCTGATATGTTCTGGAGATACTTTGCTTTTAATTGAAGGACAACTTCCTCCTC
TGGGTTTCCTGAAGGTGCCCATCTGGTGGTACCAGCTTCAGGGTCCCTCAGGACACTGGGAGAGTCATCAGGACCAGACCAACTGTACTT
CGTCTTGGGGCAGAGTTTGGAGAGCCACTTCCAGCCAAGGTGCTTCTGGGAACGAGCCTGCGCAAGTTTCTCTCCTCTACTTGGGAGACA
TAGAGATCTCAGAAGATGCCACGCTGGCGGAGCTGAAGTCTCAGGCCATGACCTTGCCTCCTTTCCTGGAGTTCGGTGTCCCGTCCCCAG
CCCACCTCAGAGCCTGGACGGTGGAGAGGAAGCGCCCAGGCAGGCTTTTACGAACTGACCGGCAGCCACTCAGGGAATATAAACTAGGAC
GGAGAATTGAGATCTGCTTAGAGCCCCTTCAGAAAGGCGAAAACTTGGGCCCCCAGGACGTGCTGCTGAGGACACAGGTGCGCATCCCTG
GTGAGAGGACCTATGCCCCTGCCCTGGACCTGGTGTGGAACGCGGCCCAGGGTGGGACTGCCGGCTCCCTGAGGCAGAGAGTTGCCGATT
TCTATCGTCTTCCCGTGGAGAAGATTGAAATTGCCAAATACTTTCCCGAAAAGTTCGAGTGGCTTCCGATATCTAGCTGGAACCAACAAA
TAACCAAGAGGAAAAAGAAAAAAAAACAAGATTATTTGCAAGGGGCACCGTATTACTTGAAAGACGGAGATACTATTGGTGTTAAGAATC
TCCTGATTGACGACGATGATGATTTCAGTACAATCAGAGATGACACTGGAAAAGAAAAGCAGAAACAACGGGCCCTGGGGAGAAGGAAAA
GCCAAGAAGCCCTCCATGAGCAGAGCAGCTACATCCTCTCCAGTGCAGAGACGCCTGCCCGGCCCCGAGCCCCGGAAACTTCTCTCTCCA
TCCACGTGGGGAGCTTCAGATAACCGCGCCGCTGCACGGCTCTACTCCCGATGAACTCTCCGGCTGATGCCACAAACGTGGGTTTCCTGG
GCATGGGGACTGGCTGCCTGGCGCCTCCAATCCCAAATCCTCTGCTTCCTTTGAGCACAGGGACGGCTCCTCTGAGGCCTGGCCAGTGCA
TGTAGTCACTTAGCTCTGCAACACGTGGCAGCCACGGGGGCTGGTGCAGCTCTGGATGTCGCCCACCCAGCTGCCAGTAGGTGCTGGGCT
CTCTCACACAGCACCCGGCCCCAGCTGCCTTTTTTTTTCTTTTAACCAGAAAATGCACAACGTGTGCGTGAACCGCAGGTATGGAGGCAG
CGGCATGCCGTTGCTCCGCTGTGGGAGGTGTGTGGGGTCAGGCCAGCCACTTTCCTCCGTGTTCAGATGACTCTCGTTCGCCCTGACCGG
CTTCTCACAGTGTCTCAGGCCACTGCGCCACCGCGCTGGTGCTGAGCAGAAGCGGGCAGAAGTGGGGTCTGCTTTCAGGACTTCATTTCC
CCCACTCGTTCCGGCCCCGCATGCTCCACGTCTGCCCTTTGGTCTGAGTTAAAACTGCGATGCTGAAAAGTGCGAGCTCTTTCCACGAGG
AGGAGCCACACAGGGTGGCCTCCGAGGGTGAGTCGCTCTGCTAAGCAAGGGCAGCCGCTGCACGTCAGCCCGCAGGCCAAGGGTCCAGCT
TATCCTGGGTGCTCTGTGATCAGAAGGTCCTTGGATCCCGAGGACTGCAGCTGCTGCCGTCCACAGCGCCTCAGCCTCTCTTCCTGTGTG
GAAGCGGGGCAGGCAGGGCTGTGGCAGACAGGCCTGGCATAGCCCAGGTTCCAGGTGTCCTGGGCAGCCTGACCGGTTTCCTGAGTAGCC
TCAATGAAAACACCTGAGAAAAAGAAAATGTAAACTAAGGAAGGGTTTTCCCACTTAATCCAACCCAGATTTCTATTCAACTTAAAGGAT
TTAATTGGCATTTGTGAGAAATAATAGTACCTGTGTCACTGAGTTGATTGATTTGGGACATAGACGGTTGACTTTCCCAGACAGCAGCTT
AGCGGAAAGCAGCATCCCGAAGACGGTGTCGCATGTCCTGAGCCTGCTTGTCACCTGGGCCTCACGGTTTCTCGTCAGCCCCGTCACTGA
TGGGAAGCAGCACTGAAGTGTGAGGGCAGAAAGGACACCGCTGGAGTCAGGCGCTCCCCTGCCTGTGACCCTTTTCCAACAAGCTGATGC
TGAGCCAGCGGCCTGCTTTGTCCCTCATACTCCTCCCAACAGTCCAAACCCCTACCAGACAGAAGCCACGTCGCTTCTGCACACGTGTCT
GAGAGCGTCTGCCATAGACGTCTGTGCGTTTCCGTGAAGCACTGCGCCCTAAGGACCCAACTCTGACTAGCAGCTGCCTCCCACTCCCAA
ACACTAACCCCGCTCAGGAGACTCGCACTGGGTGTAGACTGCGTCTTTGCAGAGGGAGATGATAGAGGCTTCTGATGACGCCAGAGCTGT
AAGTGTCGTGACGAGCTGGGCGCCCAGCCCTTCTTAAGCTGTTCTGTTTCTGTGGCTTTAACTGACATATTTCTGTAGCATCTGCCTTCA
TCTCATCTCAGCGTAATGAAATATTAATGAAATCGCTGAAAAGCTTTGCCTTCGAGAGGCCAGAAGCCTCGCGGAATGTCTGCAAGTCCA
AAGACGCGTGTGGGTTGTGCCCTGAAGTGCCGTCCAGCAGGCGCGTGCGGCCGGGCCGGCCTGTGCGTGTGGCCTTTGCCTTCTTCCCTT
TCTTCCTGTTTTCTGTTTTTTTAATTTGGGGATTGAGAAAGCTGTACGATTTTGTTAAAGAAAAAAATAAACCATTTTTTAAAGTTGTAG

>59403_59403_6_NMD3-USP40_NMD3_chr3_160953000_ENST00000460469_USP40_chr2_234407258_ENST00000450966_length(amino acids)=545AA_BP=192
MEYMAESTDRSPGHILCCECGVPISPNPANICVACLRSKVDISQGIPKQVSISFCKQCQRYFQPPGTWIQCALESRELLALCLKKIKAPL
SKVRLVDAGFVWTEPHSKRLKVKLTIQKEVMNGAILQQVFVVDYVVQSQMCGDCHRVEAKDFWKAVIQVRQKTLHKKTFYYLEQLILKYG
MHQNTLRIKEIHGDAWHLRKMDWCYEAGEPLCEEDATLKELLICSGDTLLLIEGQLPPLGFLKVPIWWYQLQGPSGHWESHQDQTNCTSS
WGRVWRATSSQGASGNEPAQVSLLYLGDIEISEDATLAELKSQAMTLPPFLEFGVPSPAHLRAWTVERKRPGRLLRTDRQPLREYKLGRR
IEICLEPLQKGENLGPQDVLLRTQVRIPGERTYAPALDLVWNAAQGGTAGSLRQRVADFYRLPVEKIEIAKYFPEKFEWLPISSWNQQIT
KRKKKKKQDYLQGAPYYLKDGDTIGVKNLLIDDDDDFSTIRDDTGKEKQKQRALGRRKSQEALHEQSSYILSSAETPARPRAPETSLSIH

--------------------------------------------------------------
>59403_59403_7_NMD3-USP40_NMD3_chr3_160953000_ENST00000472947_USP40_chr2_234407258_ENST00000251722_length(transcript)=3626nt_BP=699nt
CTTCTCTGTGGCGGAGACAGCCAGGTTGGCAGCTGACGGGACAGCCGGGGTCTATTTTGTTGCGGGTTTTCAGCAAATCCAGGGCTGGTC
TGGAGGCGCGAAAACTTAAGGCATACAGAACGATGGAGTATATGGCAGAATCCACCGACCGCAGCCCTGGACACATCTTGTGCTGTGAGT
GTGGTGTTCCGATAAGTCCAAATCCTGCCAATATTTGTGTGGCCTGTTTGCGAAGTAAAGTGGACATCAGCCAAGGTATTCCGAAACAAG
TCTCGATTTCGTTCTGCAAACAATGTCAAAGGTATTTTCAACCACCAGGAACTTGGATACAGTGTGCTTTAGAATCCAGGGAACTTCTTG
CTTTGTGCTTGAAAAAAATCAAAGCCCCTCTGAGTAAGGTACGGCTTGTAGATGCAGGCTTTGTTTGGACTGAGCCTCATTCTAAGAGAC
TTAAAGTTAAACTGACTATTCAGAAAGAGGTGATGAATGGTGCTATCCTTCAACAAGTGTTTGTGGTGGATTATGTTGTTCAGTCCCAAA
TGTGTGGAGATTGCCATAGAGTAGAAGCTAAGGATTTCTGGAAGGCTGTGATTCAAGTGAGGCAAAAGACTTTGCATAAAAAAACTTTCT
ACTATCTGGAACAGTTAATTCTGAAATATGGAATGCATCAGAATACACTTCGTATCAAAGAGATTCATGGAGATGCCTGGCATTTACGAA
AAATGGATTGGTGCTATGAAGCTGGAGAGCCTTTATGTGAAGAAGATGCAACACTGAAAGAACTTCTGATATGTTCTGGAGATACTTTGC
TTTTAATTGAAGGACAACTTCCTCCTCTGGGTTTCCTGAAGGTGCCCATCTGGTGGTACCAGCTTCAGGGTCCCTCAGGACACTGGGAGA
GTCATCAGGACCAGACCAACTGTACTTCGTCTTGGGGCAGAGTTTGGAGAGCCACTTCCAGCCAAGGTGCTTCTGGGAACGAGCCTGCGC
AAGTTTCTCTCCTCTACTTGGGAGACATAGAGATCTCAGAAGATGCCACGCTGGCGGAGCTGAAGTCTCAGGCCATGACCTTGCCTCCTT
TCCTGGAGTTCGGTGTCCCGTCCCCAGCCCACCTCAGAGCCTGGACGGTGGAGAGGAAGCGCCCAGGCAGGCTTTTACGAACTGACCGGC
AGCCACTCAGGGAATATAAACTAGGACGGAGAATTGAGATCTGCTTAGAGCCCCTTCAGAAAGGCGAAAACTTGGGCCCCCAGGACGTGC
TGCTGAGGACACAGGTGCGCATCCCTGGTGAGAGGACCTATGCCCCTGCCCTGGACCTGGTGTGGAACGCGGCCCAGGGTGGGACTGCCG
GCTCCCTGAGGCAGAGAGTTGCCGATTTCTATCGTCTTCCCGTGGAGAAGATTGAAATTGCCAAATACTTTCCCGAAAAGTTCGAGTGGC
TTCCGATATCTAGCTGGAACCAACAAATAACCAAGAGGAAAAAGAAAAAAAAACAAGATTATTTGCAAGGGGCACCGTATTACTTGAAAG
ACGGAGATACTATTGGTGTTAAGAATCTCCTGATTGACGACGATGATGATTTCAGTACAATCAGAGATGACACTGGAAAAGAAAAGCAGA
AACAACGGGCCCTGGGGAGAAGGAAAAGCCAAGAAGCCCTCCATGAGCAGAGCAGCTACATCCTCTCCAGTGCAGAGACGCCTGCCCGGC
CCCGAGCCCCGGAAACTTCTCTCTCCATCCACGTGGGGAGCTTCAGATAACCGCGCCGCTGCACGGCTCTACTCCCGATGAACTCTCCGG
CTGATGCCACAAACGTGGGTTTCCTGGGCATGGGGACTGGCTGCCTGGCGCCTCCAATCCCAAATCCTCTGCTTCCTTTGAGCACAGGGA
CGGCTCCTCTGAGGCCTGGCCAGTGCATGTAGTCACTTAGCTCTGCAACACGTGGCAGCCACGGGGGCTGGTGCAGCTCTGGATGTCGCC
CACCCAGCTGCCAGTAGGTGCTGGGCTCTCTCACACAGCACCCGGCCCCAGCTGCCTTTTTTTTTCTTTTAACCAGAAAATGCACAACGT
GTGCGTGAACCGCAGGTATGGAGGCAGCGGCATGCCGTTGCTCCGCTGTGGGAGGTGTGTGGGGTCAGGCCAGCCACTTTCCTCCGTGTT
CAGATGACTCTCGTTCGCCCTGACCGGCTTCTCACAGTGTCTCAGGCCACTGCGCCACCGCGCTGGTGCTGAGCAGAAGCGGGCAGAAGT
GGGGTCTGCTTTCAGGACTTCATTTCCCCCACTCGTTCCGGCCCCGCATGCTCCACGTCTGCCCTTTGGTCTGAGTTAAAACTGCGATGC
TGAAAAGTGCGAGCTCTTTCCACGAGGAGGAGCCACACAGGGTGGCCTCCGAGGGTGAGTCGCTCTGCTAAGCAAGGGCAGCCGCTGCAC
GTCAGCCCGCAGGCCAAGGGTCCAGCTTATCCTGGGTGCTCTGTGATCAGAAGGTCCTTGGATCCCGAGGACTGCAGCTGCTGCCGTCCA
CAGCGCCTCAGCCTCTCTTCCTGTGTGGAAGCGGGGCAGGCAGGGCTGTGGCAGACAGGCCTGGCATAGCCCAGGTTCCAGGTGTCCTGG
GCAGCCTGACCGGTTTCCTGAGTAGCCTCAATGAAAACACCTGAGAAAAAGAAAATGTAAACTAAGGAAGGGTTTTCCCACTTAATCCAA
CCCAGATTTCTATTCAACTTAAAGGATTTAATTGGCATTTGTGAGAAATAATAGTACCTGTGTCACTGAGTTGATTGATTTGGGACATAG
ACGGTTGACTTTCCCAGACAGCAGCTTAGCGGAAAGCAGCATCCCGAAGACGGTGTCGCATGTCCTGAGCCTGCTTGTCACCTGGGCCTC
ACGGTTTCTCGTCAGCCCCGTCACTGATGGGAAGCAGCACTGAAGTGTGAGGGCAGAAAGGACACCGCTGGAGTCAGGCGCTCCCCTGCC
TGTGACCCTTTTCCAACAAGCTGATGCTGAGCCAGCGGCCTGCTTTGTCCCTCATACTCCTCCCAACAGTCCAAACCCCTACCAGACAGA
AGCCACGTCGCTTCTGCACACGTGTCTGAGAGCGTCTGCCATAGACGTCTGTGCGTTTCCGTGAAGCACTGCGCCCTAAGGACCCAACTC
TGACTAGCAGCTGCCTCCCACTCCCAAACACTAACCCCGCTCAGGAGACTCGCACTGGGTGTAGACTGCGTCTTTGCAGAGGGAGATGAT
AGAGGCTTCTGATGACGCCAGAGCTGTAAGTGTCGTGACGAGCTGGGCGCCCAGCCCTTCTTAAGCTGTTCTGTTTCTGTGGCTTTAACT
GACATATTTCTGTAGCATCTGCCTTCATCTCATCTCAGCGTAATGAAATATTAATGAAATCGCTGAAAAGCTTTGCCTTCGAGAGGCCAG
AAGCCTCGCGGAATGTCTGCAAGTCCAAAGACGCGTGTGGGTTGTGCCCTGAAGTGCCGTCCAGCAGGCGCGTGCGGCCGGGCCGGCCTG
TGCGTGTGGCCTTTGCCTTCTTCCCTTTCTTCCTGTTTTCTGTTTTTTTAATTTGGGGATTGAGAAAGCTGTACGATTTTGTTAAAGAAA

>59403_59403_7_NMD3-USP40_NMD3_chr3_160953000_ENST00000472947_USP40_chr2_234407258_ENST00000251722_length(amino acids)=584AA_BP=231
MWRRQPGWQLTGQPGSILLRVFSKSRAGLEARKLKAYRTMEYMAESTDRSPGHILCCECGVPISPNPANICVACLRSKVDISQGIPKQVS
ISFCKQCQRYFQPPGTWIQCALESRELLALCLKKIKAPLSKVRLVDAGFVWTEPHSKRLKVKLTIQKEVMNGAILQQVFVVDYVVQSQMC
GDCHRVEAKDFWKAVIQVRQKTLHKKTFYYLEQLILKYGMHQNTLRIKEIHGDAWHLRKMDWCYEAGEPLCEEDATLKELLICSGDTLLL
IEGQLPPLGFLKVPIWWYQLQGPSGHWESHQDQTNCTSSWGRVWRATSSQGASGNEPAQVSLLYLGDIEISEDATLAELKSQAMTLPPFL
EFGVPSPAHLRAWTVERKRPGRLLRTDRQPLREYKLGRRIEICLEPLQKGENLGPQDVLLRTQVRIPGERTYAPALDLVWNAAQGGTAGS
LRQRVADFYRLPVEKIEIAKYFPEKFEWLPISSWNQQITKRKKKKKQDYLQGAPYYLKDGDTIGVKNLLIDDDDDFSTIRDDTGKEKQKQ

--------------------------------------------------------------
>59403_59403_8_NMD3-USP40_NMD3_chr3_160953000_ENST00000472947_USP40_chr2_234407258_ENST00000427112_length(transcript)=1760nt_BP=699nt
CTTCTCTGTGGCGGAGACAGCCAGGTTGGCAGCTGACGGGACAGCCGGGGTCTATTTTGTTGCGGGTTTTCAGCAAATCCAGGGCTGGTC
TGGAGGCGCGAAAACTTAAGGCATACAGAACGATGGAGTATATGGCAGAATCCACCGACCGCAGCCCTGGACACATCTTGTGCTGTGAGT
GTGGTGTTCCGATAAGTCCAAATCCTGCCAATATTTGTGTGGCCTGTTTGCGAAGTAAAGTGGACATCAGCCAAGGTATTCCGAAACAAG
TCTCGATTTCGTTCTGCAAACAATGTCAAAGGTATTTTCAACCACCAGGAACTTGGATACAGTGTGCTTTAGAATCCAGGGAACTTCTTG
CTTTGTGCTTGAAAAAAATCAAAGCCCCTCTGAGTAAGGTACGGCTTGTAGATGCAGGCTTTGTTTGGACTGAGCCTCATTCTAAGAGAC
TTAAAGTTAAACTGACTATTCAGAAAGAGGTGATGAATGGTGCTATCCTTCAACAAGTGTTTGTGGTGGATTATGTTGTTCAGTCCCAAA
TGTGTGGAGATTGCCATAGAGTAGAAGCTAAGGATTTCTGGAAGGCTGTGATTCAAGTGAGGCAAAAGACTTTGCATAAAAAAACTTTCT
ACTATCTGGAACAGTTAATTCTGAAATATGGAATGCATCAGAATACACTTCGTATCAAAGAGATTCATGGAGATGCCTGGCATTTACGAA
AAATGGATTGGTGCTATGAAGCTGGAGAGCCTTTATGTGAAGAAGATGCAACACTGAAAGAACTTCTGATATGTTCTGGAGATACTTTGC
TTTTAATTGAAGGACAACTTCCTCCTCTGGGTTTCCTGAAGGTGCCCATCTGGTGGTACCAGCTTCAGGGTCCCTCAGGACACTGGGAGA
GTCATCAGGACCAGACCAACTGTACTTCGTCTTGGGGCAGAGTTTGGAGAGCCACTTCCAGCCAAGGTGCTTCTGGGAACGAGCCTGCGC
AAGTTTCTCTCCTCTACTTGGGAGACATAGAGATCTCAGAAGATGCCACGCTGGCGGAGCTGAAGTCTCAGGCCATGACCTTGCCTCCTT
TCCTGGAGTTCGGTGTCCCGTCCCCAGCCCACCTCAGAGCCTGGACGGTGGAGAGGAAGCGCCCAGGCAGGCTTTTACGAACTGACCGGC
AGCCACTCAGGGAATATAAACTAGGACGGAGAATTGAGATCTGCTTAGAGCCCCTTCAGAAAGGCGAAAACTTGGGCCCCCAGGACGTGC
TGCTGAGGACACAGGTGCGCATCCCTGGTGAGAGGACCTATGCCCCTGCCCTGGACCTGGTGTGGAACGCGGCCCAGGGTGGGACTGCCG
GCTCCCTGAGGCAGAGAGTTGCCGATTTCTATCGTCTTCCCGTGGAGAAGATTGAAATTGCCAAATACTTTCCCGAAAAGTTCGAGTGGC
TTCCGATATCTAGCTGGAACCAACAAATAACCAAGAGGAAAAAGAAAAAAAAACAAGATTATTTGCAAGGGGCACCGTATTACTTGAAAG
ACGGAGATACTATTGGTGTTAAGAATCTCCTGATTGACGACGATGATGATTTCAGTACAATCAGAGATGACACTGGAAAAGAAAAGCAGA
AACAACGGGCCCTGGGGAGAAGGAAAAGCCAAGAAGCCCTCCATGAGCAGAGCAGCTACATCCTCTCCAGTGCAGAGACGCCTGCCCGGC

>59403_59403_8_NMD3-USP40_NMD3_chr3_160953000_ENST00000472947_USP40_chr2_234407258_ENST00000427112_length(amino acids)=585AA_BP=231
MWRRQPGWQLTGQPGSILLRVFSKSRAGLEARKLKAYRTMEYMAESTDRSPGHILCCECGVPISPNPANICVACLRSKVDISQGIPKQVS
ISFCKQCQRYFQPPGTWIQCALESRELLALCLKKIKAPLSKVRLVDAGFVWTEPHSKRLKVKLTIQKEVMNGAILQQVFVVDYVVQSQMC
GDCHRVEAKDFWKAVIQVRQKTLHKKTFYYLEQLILKYGMHQNTLRIKEIHGDAWHLRKMDWCYEAGEPLCEEDATLKELLICSGDTLLL
IEGQLPPLGFLKVPIWWYQLQGPSGHWESHQDQTNCTSSWGRVWRATSSQGASGNEPAQVSLLYLGDIEISEDATLAELKSQAMTLPPFL
EFGVPSPAHLRAWTVERKRPGRLLRTDRQPLREYKLGRRIEICLEPLQKGENLGPQDVLLRTQVRIPGERTYAPALDLVWNAAQGGTAGS
LRQRVADFYRLPVEKIEIAKYFPEKFEWLPISSWNQQITKRKKKKKQDYLQGAPYYLKDGDTIGVKNLLIDDDDDFSTIRDDTGKEKQKQ

--------------------------------------------------------------
>59403_59403_9_NMD3-USP40_NMD3_chr3_160953000_ENST00000472947_USP40_chr2_234407258_ENST00000450966_length(transcript)=3632nt_BP=699nt
CTTCTCTGTGGCGGAGACAGCCAGGTTGGCAGCTGACGGGACAGCCGGGGTCTATTTTGTTGCGGGTTTTCAGCAAATCCAGGGCTGGTC
TGGAGGCGCGAAAACTTAAGGCATACAGAACGATGGAGTATATGGCAGAATCCACCGACCGCAGCCCTGGACACATCTTGTGCTGTGAGT
GTGGTGTTCCGATAAGTCCAAATCCTGCCAATATTTGTGTGGCCTGTTTGCGAAGTAAAGTGGACATCAGCCAAGGTATTCCGAAACAAG
TCTCGATTTCGTTCTGCAAACAATGTCAAAGGTATTTTCAACCACCAGGAACTTGGATACAGTGTGCTTTAGAATCCAGGGAACTTCTTG
CTTTGTGCTTGAAAAAAATCAAAGCCCCTCTGAGTAAGGTACGGCTTGTAGATGCAGGCTTTGTTTGGACTGAGCCTCATTCTAAGAGAC
TTAAAGTTAAACTGACTATTCAGAAAGAGGTGATGAATGGTGCTATCCTTCAACAAGTGTTTGTGGTGGATTATGTTGTTCAGTCCCAAA
TGTGTGGAGATTGCCATAGAGTAGAAGCTAAGGATTTCTGGAAGGCTGTGATTCAAGTGAGGCAAAAGACTTTGCATAAAAAAACTTTCT
ACTATCTGGAACAGTTAATTCTGAAATATGGAATGCATCAGAATACACTTCGTATCAAAGAGATTCATGGAGATGCCTGGCATTTACGAA
AAATGGATTGGTGCTATGAAGCTGGAGAGCCTTTATGTGAAGAAGATGCAACACTGAAAGAACTTCTGATATGTTCTGGAGATACTTTGC
TTTTAATTGAAGGACAACTTCCTCCTCTGGGTTTCCTGAAGGTGCCCATCTGGTGGTACCAGCTTCAGGGTCCCTCAGGACACTGGGAGA
GTCATCAGGACCAGACCAACTGTACTTCGTCTTGGGGCAGAGTTTGGAGAGCCACTTCCAGCCAAGGTGCTTCTGGGAACGAGCCTGCGC
AAGTTTCTCTCCTCTACTTGGGAGACATAGAGATCTCAGAAGATGCCACGCTGGCGGAGCTGAAGTCTCAGGCCATGACCTTGCCTCCTT
TCCTGGAGTTCGGTGTCCCGTCCCCAGCCCACCTCAGAGCCTGGACGGTGGAGAGGAAGCGCCCAGGCAGGCTTTTACGAACTGACCGGC
AGCCACTCAGGGAATATAAACTAGGACGGAGAATTGAGATCTGCTTAGAGCCCCTTCAGAAAGGCGAAAACTTGGGCCCCCAGGACGTGC
TGCTGAGGACACAGGTGCGCATCCCTGGTGAGAGGACCTATGCCCCTGCCCTGGACCTGGTGTGGAACGCGGCCCAGGGTGGGACTGCCG
GCTCCCTGAGGCAGAGAGTTGCCGATTTCTATCGTCTTCCCGTGGAGAAGATTGAAATTGCCAAATACTTTCCCGAAAAGTTCGAGTGGC
TTCCGATATCTAGCTGGAACCAACAAATAACCAAGAGGAAAAAGAAAAAAAAACAAGATTATTTGCAAGGGGCACCGTATTACTTGAAAG
ACGGAGATACTATTGGTGTTAAGAATCTCCTGATTGACGACGATGATGATTTCAGTACAATCAGAGATGACACTGGAAAAGAAAAGCAGA
AACAACGGGCCCTGGGGAGAAGGAAAAGCCAAGAAGCCCTCCATGAGCAGAGCAGCTACATCCTCTCCAGTGCAGAGACGCCTGCCCGGC
CCCGAGCCCCGGAAACTTCTCTCTCCATCCACGTGGGGAGCTTCAGATAACCGCGCCGCTGCACGGCTCTACTCCCGATGAACTCTCCGG
CTGATGCCACAAACGTGGGTTTCCTGGGCATGGGGACTGGCTGCCTGGCGCCTCCAATCCCAAATCCTCTGCTTCCTTTGAGCACAGGGA
CGGCTCCTCTGAGGCCTGGCCAGTGCATGTAGTCACTTAGCTCTGCAACACGTGGCAGCCACGGGGGCTGGTGCAGCTCTGGATGTCGCC
CACCCAGCTGCCAGTAGGTGCTGGGCTCTCTCACACAGCACCCGGCCCCAGCTGCCTTTTTTTTTCTTTTAACCAGAAAATGCACAACGT
GTGCGTGAACCGCAGGTATGGAGGCAGCGGCATGCCGTTGCTCCGCTGTGGGAGGTGTGTGGGGTCAGGCCAGCCACTTTCCTCCGTGTT
CAGATGACTCTCGTTCGCCCTGACCGGCTTCTCACAGTGTCTCAGGCCACTGCGCCACCGCGCTGGTGCTGAGCAGAAGCGGGCAGAAGT
GGGGTCTGCTTTCAGGACTTCATTTCCCCCACTCGTTCCGGCCCCGCATGCTCCACGTCTGCCCTTTGGTCTGAGTTAAAACTGCGATGC
TGAAAAGTGCGAGCTCTTTCCACGAGGAGGAGCCACACAGGGTGGCCTCCGAGGGTGAGTCGCTCTGCTAAGCAAGGGCAGCCGCTGCAC
GTCAGCCCGCAGGCCAAGGGTCCAGCTTATCCTGGGTGCTCTGTGATCAGAAGGTCCTTGGATCCCGAGGACTGCAGCTGCTGCCGTCCA
CAGCGCCTCAGCCTCTCTTCCTGTGTGGAAGCGGGGCAGGCAGGGCTGTGGCAGACAGGCCTGGCATAGCCCAGGTTCCAGGTGTCCTGG
GCAGCCTGACCGGTTTCCTGAGTAGCCTCAATGAAAACACCTGAGAAAAAGAAAATGTAAACTAAGGAAGGGTTTTCCCACTTAATCCAA
CCCAGATTTCTATTCAACTTAAAGGATTTAATTGGCATTTGTGAGAAATAATAGTACCTGTGTCACTGAGTTGATTGATTTGGGACATAG
ACGGTTGACTTTCCCAGACAGCAGCTTAGCGGAAAGCAGCATCCCGAAGACGGTGTCGCATGTCCTGAGCCTGCTTGTCACCTGGGCCTC
ACGGTTTCTCGTCAGCCCCGTCACTGATGGGAAGCAGCACTGAAGTGTGAGGGCAGAAAGGACACCGCTGGAGTCAGGCGCTCCCCTGCC
TGTGACCCTTTTCCAACAAGCTGATGCTGAGCCAGCGGCCTGCTTTGTCCCTCATACTCCTCCCAACAGTCCAAACCCCTACCAGACAGA
AGCCACGTCGCTTCTGCACACGTGTCTGAGAGCGTCTGCCATAGACGTCTGTGCGTTTCCGTGAAGCACTGCGCCCTAAGGACCCAACTC
TGACTAGCAGCTGCCTCCCACTCCCAAACACTAACCCCGCTCAGGAGACTCGCACTGGGTGTAGACTGCGTCTTTGCAGAGGGAGATGAT
AGAGGCTTCTGATGACGCCAGAGCTGTAAGTGTCGTGACGAGCTGGGCGCCCAGCCCTTCTTAAGCTGTTCTGTTTCTGTGGCTTTAACT
GACATATTTCTGTAGCATCTGCCTTCATCTCATCTCAGCGTAATGAAATATTAATGAAATCGCTGAAAAGCTTTGCCTTCGAGAGGCCAG
AAGCCTCGCGGAATGTCTGCAAGTCCAAAGACGCGTGTGGGTTGTGCCCTGAAGTGCCGTCCAGCAGGCGCGTGCGGCCGGGCCGGCCTG
TGCGTGTGGCCTTTGCCTTCTTCCCTTTCTTCCTGTTTTCTGTTTTTTTAATTTGGGGATTGAGAAAGCTGTACGATTTTGTTAAAGAAA

>59403_59403_9_NMD3-USP40_NMD3_chr3_160953000_ENST00000472947_USP40_chr2_234407258_ENST00000450966_length(amino acids)=584AA_BP=231
MWRRQPGWQLTGQPGSILLRVFSKSRAGLEARKLKAYRTMEYMAESTDRSPGHILCCECGVPISPNPANICVACLRSKVDISQGIPKQVS
ISFCKQCQRYFQPPGTWIQCALESRELLALCLKKIKAPLSKVRLVDAGFVWTEPHSKRLKVKLTIQKEVMNGAILQQVFVVDYVVQSQMC
GDCHRVEAKDFWKAVIQVRQKTLHKKTFYYLEQLILKYGMHQNTLRIKEIHGDAWHLRKMDWCYEAGEPLCEEDATLKELLICSGDTLLL
IEGQLPPLGFLKVPIWWYQLQGPSGHWESHQDQTNCTSSWGRVWRATSSQGASGNEPAQVSLLYLGDIEISEDATLAELKSQAMTLPPFL
EFGVPSPAHLRAWTVERKRPGRLLRTDRQPLREYKLGRRIEICLEPLQKGENLGPQDVLLRTQVRIPGERTYAPALDLVWNAAQGGTAGS
LRQRVADFYRLPVEKIEIAKYFPEKFEWLPISSWNQQITKRKKKKKQDYLQGAPYYLKDGDTIGVKNLLIDDDDDFSTIRDDTGKEKQKQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NMD3-USP40


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NMD3-USP40


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NMD3-USP40


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource