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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NME2-ACBD4 (FusionGDB2 ID:59416)

Fusion Gene Summary for NME2-ACBD4

check button Fusion gene summary
Fusion gene informationFusion gene name: NME2-ACBD4
Fusion gene ID: 59416
HgeneTgene
Gene symbol

NME2

ACBD4

Gene ID

4831

79777

Gene nameNME/NM23 nucleoside diphosphate kinase 2acyl-CoA binding domain containing 4
SynonymsNDKB|NDPK-B|NDPKB|NM23-H2|NM23B|PUFHMFT0700
Cytomap

17q21.33

17q21.31

Type of geneprotein-codingprotein-coding
Descriptionnucleoside diphosphate kinase BHEL-S-155anNDP kinase Bc-myc purine-binding transcription factor PUFc-myc transcription factorepididymis secretory sperm binding protein Li 155anhistidine protein kinase NDKBnon-metastatic cells 2, protein (NM23) expracyl-CoA-binding domain-containing protein 4acyl-Coenzyme A binding domain containing 4
Modification date2020032720200320
UniProtAcc

P22392

Q8NC06

Ensembl transtripts involved in fusion geneENST00000376392, ENST00000393193, 
ENST00000555572, 		ENST00000321854, 
ENST00000376955, ENST00000591136, 
ENST00000592162, ENST00000398322, 
ENST00000431281, ENST00000586346, 
ENST00000591859, 
Fusion gene scores* DoF score6 X 6 X 4=1442 X 2 X 2=8
# samples 62
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: NME2 [Title/Abstract] AND ACBD4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNME2(49244317)-ACBD4(43216388), # samples:2
Anticipated loss of major functional domain due to fusion event.NME2-ACBD4 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NME2-ACBD4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NME2-ACBD4 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
NME2-ACBD4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNME2

GO:0006165

nucleoside diphosphate phosphorylation

25679041

HgeneNME2

GO:0007229

integrin-mediated signaling pathway

11919189

HgeneNME2

GO:0009142

nucleoside triphosphate biosynthetic process

1851158|25679041

HgeneNME2

GO:0045893

positive regulation of transcription, DNA-templated

8392752

HgeneNME2

GO:0045944

positive regulation of transcription by RNA polymerase II

15703214


check buttonFusion gene breakpoints across NME2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ACBD4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-44-3396-01ANME2chr17

49244317

+ACBD4chr17

43216388

+


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Fusion Gene ORF analysis for NME2-ACBD4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000376392ENST00000321854NME2chr17

49244317

+ACBD4chr17

43216388

+
5CDS-intronENST00000376392ENST00000376955NME2chr17

49244317

+ACBD4chr17

43216388

+
5CDS-intronENST00000376392ENST00000591136NME2chr17

49244317

+ACBD4chr17

43216388

+
5CDS-intronENST00000376392ENST00000592162NME2chr17

49244317

+ACBD4chr17

43216388

+
5CDS-intronENST00000393193ENST00000321854NME2chr17

49244317

+ACBD4chr17

43216388

+
5CDS-intronENST00000393193ENST00000376955NME2chr17

49244317

+ACBD4chr17

43216388

+
5CDS-intronENST00000393193ENST00000591136NME2chr17

49244317

+ACBD4chr17

43216388

+
5CDS-intronENST00000393193ENST00000592162NME2chr17

49244317

+ACBD4chr17

43216388

+
5CDS-intronENST00000555572ENST00000321854NME2chr17

49244317

+ACBD4chr17

43216388

+
5CDS-intronENST00000555572ENST00000376955NME2chr17

49244317

+ACBD4chr17

43216388

+
5CDS-intronENST00000555572ENST00000591136NME2chr17

49244317

+ACBD4chr17

43216388

+
5CDS-intronENST00000555572ENST00000592162NME2chr17

49244317

+ACBD4chr17

43216388

+
Frame-shiftENST00000376392ENST00000398322NME2chr17

49244317

+ACBD4chr17

43216388

+
Frame-shiftENST00000393193ENST00000398322NME2chr17

49244317

+ACBD4chr17

43216388

+
Frame-shiftENST00000555572ENST00000398322NME2chr17

49244317

+ACBD4chr17

43216388

+
In-frameENST00000376392ENST00000431281NME2chr17

49244317

+ACBD4chr17

43216388

+
In-frameENST00000376392ENST00000586346NME2chr17

49244317

+ACBD4chr17

43216388

+
In-frameENST00000376392ENST00000591859NME2chr17

49244317

+ACBD4chr17

43216388

+
In-frameENST00000393193ENST00000431281NME2chr17

49244317

+ACBD4chr17

43216388

+
In-frameENST00000393193ENST00000586346NME2chr17

49244317

+ACBD4chr17

43216388

+
In-frameENST00000393193ENST00000591859NME2chr17

49244317

+ACBD4chr17

43216388

+
In-frameENST00000555572ENST00000431281NME2chr17

49244317

+ACBD4chr17

43216388

+
In-frameENST00000555572ENST00000586346NME2chr17

49244317

+ACBD4chr17

43216388

+
In-frameENST00000555572ENST00000591859NME2chr17

49244317

+ACBD4chr17

43216388

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393193NME2chr1749244317+ENST00000431281ACBD4chr1743216388+141854838886282
ENST00000393193NME2chr1749244317+ENST00000591859ACBD4chr1743216388+142254838886282
ENST00000393193NME2chr1749244317+ENST00000586346ACBD4chr1743216388+109654838886282
ENST00000376392NME2chr1749244317+ENST00000431281ACBD4chr1743216388+140453424872282
ENST00000376392NME2chr1749244317+ENST00000591859ACBD4chr1743216388+140853424872282
ENST00000376392NME2chr1749244317+ENST00000586346ACBD4chr1743216388+108253424872282
ENST00000555572NME2chr1749244317+ENST00000431281ACBD4chr1743216388+15927221761060294
ENST00000555572NME2chr1749244317+ENST00000591859ACBD4chr1743216388+15967221761060294
ENST00000555572NME2chr1749244317+ENST00000586346ACBD4chr1743216388+12707221761060294

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393193ENST00000431281NME2chr1749244317+ACBD4chr1743216388+0.31645150.68354845
ENST00000393193ENST00000591859NME2chr1749244317+ACBD4chr1743216388+0.309814130.6901859
ENST00000393193ENST00000586346NME2chr1749244317+ACBD4chr1743216388+0.211469670.78853035
ENST00000376392ENST00000431281NME2chr1749244317+ACBD4chr1743216388+0.323275120.6767249
ENST00000376392ENST00000591859NME2chr1749244317+ACBD4chr1743216388+0.31948420.6805158
ENST00000376392ENST00000586346NME2chr1749244317+ACBD4chr1743216388+0.218256740.7817433
ENST00000555572ENST00000431281NME2chr1749244317+ACBD4chr1743216388+0.37498530.6250147
ENST00000555572ENST00000591859NME2chr1749244317+ACBD4chr1743216388+0.37144870.6285513
ENST00000555572ENST00000586346NME2chr1749244317+ACBD4chr1743216388+0.332068620.66793144

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Fusion Genomic Features for NME2-ACBD4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NME2chr1749244317+ACBD4chr1743216387+8.03E-091
NME2chr1749244317+ACBD4chr1743216387+8.03E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NME2-ACBD4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:49244317/chr17:43216388)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NME2

P22392

ACBD4

Q8NC06

FUNCTION: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC (PubMed:15249197). Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752, PubMed:19435876). Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1) (PubMed:19435876). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (PubMed:25679041). Exhibits histidine protein kinase activity (PubMed:20946858). {ECO:0000250|UniProtKB:P36010, ECO:0000269|PubMed:15249197, ECO:0000269|PubMed:19435876, ECO:0000269|PubMed:20946858, ECO:0000269|PubMed:25679041, ECO:0000269|PubMed:8392752}.FUNCTION: Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneACBD4chr17:49244317chr17:43216388ENST0000032185471012_101216306.0DomainACB
TgeneACBD4chr17:49244317chr17:43216388ENST0000037695571012_101213269.0DomainACB
TgeneACBD4chr17:49244317chr17:43216388ENST000003983226912_101216306.0DomainACB
TgeneACBD4chr17:49244317chr17:43216388ENST0000043128191212_101229342.0DomainACB
TgeneACBD4chr17:49244317chr17:43216388ENST0000058634671012_101229342.0DomainACB
TgeneACBD4chr17:49244317chr17:43216388ENST0000059185991212_101229342.0DomainACB
TgeneACBD4chr17:49244317chr17:43216388ENST0000032185471023_32216306.0RegionNote=Acyl-CoA binding
TgeneACBD4chr17:49244317chr17:43216388ENST0000032185471043_47216306.0RegionNote=Acyl-CoA binding
TgeneACBD4chr17:49244317chr17:43216388ENST0000037695571023_32213269.0RegionNote=Acyl-CoA binding
TgeneACBD4chr17:49244317chr17:43216388ENST0000037695571043_47213269.0RegionNote=Acyl-CoA binding
TgeneACBD4chr17:49244317chr17:43216388ENST000003983226923_32216306.0RegionNote=Acyl-CoA binding
TgeneACBD4chr17:49244317chr17:43216388ENST000003983226943_47216306.0RegionNote=Acyl-CoA binding
TgeneACBD4chr17:49244317chr17:43216388ENST0000043128191223_32229342.0RegionNote=Acyl-CoA binding
TgeneACBD4chr17:49244317chr17:43216388ENST0000043128191243_47229342.0RegionNote=Acyl-CoA binding
TgeneACBD4chr17:49244317chr17:43216388ENST0000058634671023_32229342.0RegionNote=Acyl-CoA binding
TgeneACBD4chr17:49244317chr17:43216388ENST0000058634671043_47229342.0RegionNote=Acyl-CoA binding
TgeneACBD4chr17:49244317chr17:43216388ENST0000059185991223_32229342.0RegionNote=Acyl-CoA binding
TgeneACBD4chr17:49244317chr17:43216388ENST0000059185991243_47229342.0RegionNote=Acyl-CoA binding


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Fusion Gene Sequence for NME2-ACBD4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>59416_59416_1_NME2-ACBD4_NME2_chr17_49244317_ENST00000376392_ACBD4_chr17_43216388_ENST00000431281_length(transcript)=1404nt_BP=534nt
CGGGCGCGTTTCGGGTGCTGGCGGCTGCAGCCGGAGTTCAAACCTAAGCAGCTGGAAGGAACCATGGCCAACTGTGAGCGTACCTTCATT
GCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGATTCCGCCTTGTTGGTCTGAAA
TTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGGTGAAATACATGCAC
TCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAACCCTGCAGACTCC
AAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTCATCGCCATCAAGCCGGAC
GGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGTTCCTCCGGAGGGGT
TGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCACTACAGGAGAGCATGCAGGAGGTGCAGG
CGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCAGTGCTCGGCCATGGCCCCTTGGGCTCC
CGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGTTTCGGACCCAAAAGAGGTGACTGTCAG
TGGAGGGGTCTCTGCAGCCAACTGAGACTATCTTGCTGTGCCCTGAGCCTTCCTAGGGTTTAGAAGAACAGCATTCAAAATTCCCCGTCC
TGTCAGTGTTTGCCTTCGCACCTCCTCCCCTAAAGCAGCGCGGGGGGCAAATAAGACCCCACCCCTCCCTGCAGCTTCACAGGGACGCTT
CCTTCCCTCCCCGCAACCACCCCAGGCTCCCCTGGGAGGCTGCAGTTGTGGTACACGTCCCCGGTGCTGGGTTGGCCGTGACTCGGGGGC
GGGGCGATCGGGTCTCAGCCCCTGCCTTCCCCAGTCTCTGGGTCACCCGAATTTTCCCACCCCTGCTTCTCCCCGAGGAGGTTGAGCTCT
TGAGCAAGTTGGGACTTGGGCCGGGGCCTGGAAGAATGATTGGCTGGGAGGCCGCGGGAGGGAGGCCAGGAGGCCCGGACCAGTTGGGAG
GAGTGAGCAGGCCCCGGGGGAGGGGGATGAGCGCAGTTTGCTCGCTTTCCTCCCCTGCCGGCCCCCTCCGCCCCCACACACACTCGGGAC

>59416_59416_1_NME2-ACBD4_NME2_chr17_49244317_ENST00000376392_ACBD4_chr17_43216388_ENST00000431281_length(amino acids)=282AA_BP=170
MQPEFKPKQLEGTMANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMV
WEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRRGCGAARRGP
RSWTCGCWGQFEHYRRACRRCRRGCRAWRACPGPLSRGRSPGPVLGHGPLGSRGPRCSSSSCGPSSSSGSSECFGPKRGDCQWRGLCSQL

--------------------------------------------------------------
>59416_59416_2_NME2-ACBD4_NME2_chr17_49244317_ENST00000376392_ACBD4_chr17_43216388_ENST00000586346_length(transcript)=1082nt_BP=534nt
CGGGCGCGTTTCGGGTGCTGGCGGCTGCAGCCGGAGTTCAAACCTAAGCAGCTGGAAGGAACCATGGCCAACTGTGAGCGTACCTTCATT
GCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGATTCCGCCTTGTTGGTCTGAAA
TTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGGTGAAATACATGCAC
TCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAACCCTGCAGACTCC
AAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTCATCGCCATCAAGCCGGAC
GGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGTTCCTCCGGAGGGGT
TGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCACTACAGGAGAGCATGCAGGAGGTGCAGG
CGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCAGTGCTCGGCCATGGCCCCTTGGGCTCC
CGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGTTTCGGACCCAAAAGAGGTGACTGTCAG
TGGAGGGGTCTCTGCAGCCAACTGAGACTATCTTGCTGTGCCCTGAGCCTTCCTAGGGTTTAGAAGAACAGCATTCAAAATTCCCCGTCC
TGTCAGTGTTTGCCTTCGCACCTCCTCCCCTAAAGCAGCGCGGGGGGCAAATAAGACCCCACCCCTCCCTGCAGCTTCACAGGGACGCTT
CCTTCCCTCCCCGCAACCACCCCAGGCTCCCCTGGGAGGCTGCAGTTGTGGTACACGTCCCCGGTGCTGGGTTGGCCGTGACTCGGGGGC

>59416_59416_2_NME2-ACBD4_NME2_chr17_49244317_ENST00000376392_ACBD4_chr17_43216388_ENST00000586346_length(amino acids)=282AA_BP=170
MQPEFKPKQLEGTMANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMV
WEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRRGCGAARRGP
RSWTCGCWGQFEHYRRACRRCRRGCRAWRACPGPLSRGRSPGPVLGHGPLGSRGPRCSSSSCGPSSSSGSSECFGPKRGDCQWRGLCSQL

--------------------------------------------------------------
>59416_59416_3_NME2-ACBD4_NME2_chr17_49244317_ENST00000376392_ACBD4_chr17_43216388_ENST00000591859_length(transcript)=1408nt_BP=534nt
CGGGCGCGTTTCGGGTGCTGGCGGCTGCAGCCGGAGTTCAAACCTAAGCAGCTGGAAGGAACCATGGCCAACTGTGAGCGTACCTTCATT
GCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGATTCCGCCTTGTTGGTCTGAAA
TTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGGTGAAATACATGCAC
TCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAACCCTGCAGACTCC
AAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTCATCGCCATCAAGCCGGAC
GGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGTTCCTCCGGAGGGGT
TGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCACTACAGGAGAGCATGCAGGAGGTGCAGG
CGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCAGTGCTCGGCCATGGCCCCTTGGGCTCC
CGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGTTTCGGACCCAAAAGAGGTGACTGTCAG
TGGAGGGGTCTCTGCAGCCAACTGAGACTATCTTGCTGTGCCCTGAGCCTTCCTAGGGTTTAGAAGAACAGCATTCAAAATTCCCCGTCC
TGTCAGTGTTTGCCTTCGCACCTCCTCCCCTAAAGCAGCGCGGGGGGCAAATAAGACCCCACCCCTCCCTGCAGCTTCACAGGGACGCTT
CCTTCCCTCCCCGCAACCACCCCAGGCTCCCCTGGGAGGCTGCAGTTGTGGTACACGTCCCCGGTGCTGGGTTGGCCGTGACTCGGGGGC
GGGGCGATCGGGTCTCAGCCCCTGCCTTCCCCAGTCTCTGGGTCACCCGAATTTTCCCACCCCTGCTTCTCCCCGAGGAGGTTGAGCTCT
TGAGCAAGTTGGGACTTGGGCCGGGGCCTGGAAGAATGATTGGCTGGGAGGCCGCGGGAGGGAGGCCAGGAGGCCCGGACCAGTTGGGAG
GAGTGAGCAGGCCCCGGGGGAGGGGGATGAGCGCAGTTTGCTCGCTTTCCTCCCCTGCCGGCCCCCTCCGCCCCCACACACACTCGGGAC

>59416_59416_3_NME2-ACBD4_NME2_chr17_49244317_ENST00000376392_ACBD4_chr17_43216388_ENST00000591859_length(amino acids)=282AA_BP=170
MQPEFKPKQLEGTMANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMV
WEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRRGCGAARRGP
RSWTCGCWGQFEHYRRACRRCRRGCRAWRACPGPLSRGRSPGPVLGHGPLGSRGPRCSSSSCGPSSSSGSSECFGPKRGDCQWRGLCSQL

--------------------------------------------------------------
>59416_59416_4_NME2-ACBD4_NME2_chr17_49244317_ENST00000393193_ACBD4_chr17_43216388_ENST00000431281_length(transcript)=1418nt_BP=548nt
AACCACGTGGGTCCCGGGCGCGTTTCGGGTGCTGGCGGCTGCAGCCGGAGTTCAAACCTAAGCAGCTGGAAGGAACCATGGCCAACTGTG
AGCGTACCTTCATTGCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGATTCCGCC
TTGTTGGTCTGAAATTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGG
TGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCA
ACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTCATCG
CCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGT
TCCTCCGGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCACTACAGGAGAGCAT
GCAGGAGGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCAGTGCTCGGCCATG
GCCCCTTGGGCTCCCGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGTTTCGGACCCAAAA
GAGGTGACTGTCAGTGGAGGGGTCTCTGCAGCCAACTGAGACTATCTTGCTGTGCCCTGAGCCTTCCTAGGGTTTAGAAGAACAGCATTC
AAAATTCCCCGTCCTGTCAGTGTTTGCCTTCGCACCTCCTCCCCTAAAGCAGCGCGGGGGGCAAATAAGACCCCACCCCTCCCTGCAGCT
TCACAGGGACGCTTCCTTCCCTCCCCGCAACCACCCCAGGCTCCCCTGGGAGGCTGCAGTTGTGGTACACGTCCCCGGTGCTGGGTTGGC
CGTGACTCGGGGGCGGGGCGATCGGGTCTCAGCCCCTGCCTTCCCCAGTCTCTGGGTCACCCGAATTTTCCCACCCCTGCTTCTCCCCGA
GGAGGTTGAGCTCTTGAGCAAGTTGGGACTTGGGCCGGGGCCTGGAAGAATGATTGGCTGGGAGGCCGCGGGAGGGAGGCCAGGAGGCCC
GGACCAGTTGGGAGGAGTGAGCAGGCCCCGGGGGAGGGGGATGAGCGCAGTTTGCTCGCTTTCCTCCCCTGCCGGCCCCCTCCGCCCCCA

>59416_59416_4_NME2-ACBD4_NME2_chr17_49244317_ENST00000393193_ACBD4_chr17_43216388_ENST00000431281_length(amino acids)=282AA_BP=170
MQPEFKPKQLEGTMANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMV
WEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRRGCGAARRGP
RSWTCGCWGQFEHYRRACRRCRRGCRAWRACPGPLSRGRSPGPVLGHGPLGSRGPRCSSSSCGPSSSSGSSECFGPKRGDCQWRGLCSQL

--------------------------------------------------------------
>59416_59416_5_NME2-ACBD4_NME2_chr17_49244317_ENST00000393193_ACBD4_chr17_43216388_ENST00000586346_length(transcript)=1096nt_BP=548nt
AACCACGTGGGTCCCGGGCGCGTTTCGGGTGCTGGCGGCTGCAGCCGGAGTTCAAACCTAAGCAGCTGGAAGGAACCATGGCCAACTGTG
AGCGTACCTTCATTGCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGATTCCGCC
TTGTTGGTCTGAAATTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGG
TGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCA
ACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTCATCG
CCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGT
TCCTCCGGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCACTACAGGAGAGCAT
GCAGGAGGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCAGTGCTCGGCCATG
GCCCCTTGGGCTCCCGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGTTTCGGACCCAAAA
GAGGTGACTGTCAGTGGAGGGGTCTCTGCAGCCAACTGAGACTATCTTGCTGTGCCCTGAGCCTTCCTAGGGTTTAGAAGAACAGCATTC
AAAATTCCCCGTCCTGTCAGTGTTTGCCTTCGCACCTCCTCCCCTAAAGCAGCGCGGGGGGCAAATAAGACCCCACCCCTCCCTGCAGCT
TCACAGGGACGCTTCCTTCCCTCCCCGCAACCACCCCAGGCTCCCCTGGGAGGCTGCAGTTGTGGTACACGTCCCCGGTGCTGGGTTGGC

>59416_59416_5_NME2-ACBD4_NME2_chr17_49244317_ENST00000393193_ACBD4_chr17_43216388_ENST00000586346_length(amino acids)=282AA_BP=170
MQPEFKPKQLEGTMANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMV
WEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRRGCGAARRGP
RSWTCGCWGQFEHYRRACRRCRRGCRAWRACPGPLSRGRSPGPVLGHGPLGSRGPRCSSSSCGPSSSSGSSECFGPKRGDCQWRGLCSQL

--------------------------------------------------------------
>59416_59416_6_NME2-ACBD4_NME2_chr17_49244317_ENST00000393193_ACBD4_chr17_43216388_ENST00000591859_length(transcript)=1422nt_BP=548nt
AACCACGTGGGTCCCGGGCGCGTTTCGGGTGCTGGCGGCTGCAGCCGGAGTTCAAACCTAAGCAGCTGGAAGGAACCATGGCCAACTGTG
AGCGTACCTTCATTGCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGATTCCGCC
TTGTTGGTCTGAAATTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGG
TGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCA
ACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTCATCG
CCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGT
TCCTCCGGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCACTACAGGAGAGCAT
GCAGGAGGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCAGTGCTCGGCCATG
GCCCCTTGGGCTCCCGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGTTTCGGACCCAAAA
GAGGTGACTGTCAGTGGAGGGGTCTCTGCAGCCAACTGAGACTATCTTGCTGTGCCCTGAGCCTTCCTAGGGTTTAGAAGAACAGCATTC
AAAATTCCCCGTCCTGTCAGTGTTTGCCTTCGCACCTCCTCCCCTAAAGCAGCGCGGGGGGCAAATAAGACCCCACCCCTCCCTGCAGCT
TCACAGGGACGCTTCCTTCCCTCCCCGCAACCACCCCAGGCTCCCCTGGGAGGCTGCAGTTGTGGTACACGTCCCCGGTGCTGGGTTGGC
CGTGACTCGGGGGCGGGGCGATCGGGTCTCAGCCCCTGCCTTCCCCAGTCTCTGGGTCACCCGAATTTTCCCACCCCTGCTTCTCCCCGA
GGAGGTTGAGCTCTTGAGCAAGTTGGGACTTGGGCCGGGGCCTGGAAGAATGATTGGCTGGGAGGCCGCGGGAGGGAGGCCAGGAGGCCC
GGACCAGTTGGGAGGAGTGAGCAGGCCCCGGGGGAGGGGGATGAGCGCAGTTTGCTCGCTTTCCTCCCCTGCCGGCCCCCTCCGCCCCCA

>59416_59416_6_NME2-ACBD4_NME2_chr17_49244317_ENST00000393193_ACBD4_chr17_43216388_ENST00000591859_length(amino acids)=282AA_BP=170
MQPEFKPKQLEGTMANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMV
WEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRRGCGAARRGP
RSWTCGCWGQFEHYRRACRRCRRGCRAWRACPGPLSRGRSPGPVLGHGPLGSRGPRCSSSSCGPSSSSGSSECFGPKRGDCQWRGLCSQL

--------------------------------------------------------------
>59416_59416_7_NME2-ACBD4_NME2_chr17_49244317_ENST00000555572_ACBD4_chr17_43216388_ENST00000431281_length(transcript)=1592nt_BP=722nt
GGAGTTCAAACCTAAGCAGCTGGAAGGGCCCTGTGGCTAGGTACCATAGAGTCTCTACACAGGACTAAGTCAGCCTGGTGTGCAGGGGAG
GCAGACACACAAACAGAAAATTGGACTACAGTGCTAAGATGCTGTAAGAAGAGGTTAACTAAAGGACAGGAAGATGGGGCCAAGAGATGG
TGCTACTGTCTACTTTAGGGATCGTCTTTCAAGGCGAGGGGCCTCCTATCTCAAGCTGTGATACAGGAACCATGGCCAACTGTGAGCGTA
CCTTCATTGCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGATTCCGCCTTGTTG
GTCTGAAATTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGGTGAAAT
ACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAACCCTG
CAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTCATCGCCATCA
AGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGTTCCTCC
GGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCACTACAGGAGAGCATGCAGGA
GGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCAGTGCTCGGCCATGGCCCCT
TGGGCTCCCGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGTTTCGGACCCAAAAGAGGTG
ACTGTCAGTGGAGGGGTCTCTGCAGCCAACTGAGACTATCTTGCTGTGCCCTGAGCCTTCCTAGGGTTTAGAAGAACAGCATTCAAAATT
CCCCGTCCTGTCAGTGTTTGCCTTCGCACCTCCTCCCCTAAAGCAGCGCGGGGGGCAAATAAGACCCCACCCCTCCCTGCAGCTTCACAG
GGACGCTTCCTTCCCTCCCCGCAACCACCCCAGGCTCCCCTGGGAGGCTGCAGTTGTGGTACACGTCCCCGGTGCTGGGTTGGCCGTGAC
TCGGGGGCGGGGCGATCGGGTCTCAGCCCCTGCCTTCCCCAGTCTCTGGGTCACCCGAATTTTCCCACCCCTGCTTCTCCCCGAGGAGGT
TGAGCTCTTGAGCAAGTTGGGACTTGGGCCGGGGCCTGGAAGAATGATTGGCTGGGAGGCCGCGGGAGGGAGGCCAGGAGGCCCGGACCA
GTTGGGAGGAGTGAGCAGGCCCCGGGGGAGGGGGATGAGCGCAGTTTGCTCGCTTTCCTCCCCTGCCGGCCCCCTCCGCCCCCACACACA

>59416_59416_7_NME2-ACBD4_NME2_chr17_49244317_ENST00000555572_ACBD4_chr17_43216388_ENST00000431281_length(amino acids)=294AA_BP=182
MVLLSTLGIVFQGEGPPISSCDTGTMANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLV
KYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKF
LRRGCGAARRGPRSWTCGCWGQFEHYRRACRRCRRGCRAWRACPGPLSRGRSPGPVLGHGPLGSRGPRCSSSSCGPSSSSGSSECFGPKR

--------------------------------------------------------------
>59416_59416_8_NME2-ACBD4_NME2_chr17_49244317_ENST00000555572_ACBD4_chr17_43216388_ENST00000586346_length(transcript)=1270nt_BP=722nt
GGAGTTCAAACCTAAGCAGCTGGAAGGGCCCTGTGGCTAGGTACCATAGAGTCTCTACACAGGACTAAGTCAGCCTGGTGTGCAGGGGAG
GCAGACACACAAACAGAAAATTGGACTACAGTGCTAAGATGCTGTAAGAAGAGGTTAACTAAAGGACAGGAAGATGGGGCCAAGAGATGG
TGCTACTGTCTACTTTAGGGATCGTCTTTCAAGGCGAGGGGCCTCCTATCTCAAGCTGTGATACAGGAACCATGGCCAACTGTGAGCGTA
CCTTCATTGCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGATTCCGCCTTGTTG
GTCTGAAATTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGGTGAAAT
ACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAACCCTG
CAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTCATCGCCATCA
AGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGTTCCTCC
GGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCACTACAGGAGAGCATGCAGGA
GGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCAGTGCTCGGCCATGGCCCCT
TGGGCTCCCGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGTTTCGGACCCAAAAGAGGTG
ACTGTCAGTGGAGGGGTCTCTGCAGCCAACTGAGACTATCTTGCTGTGCCCTGAGCCTTCCTAGGGTTTAGAAGAACAGCATTCAAAATT
CCCCGTCCTGTCAGTGTTTGCCTTCGCACCTCCTCCCCTAAAGCAGCGCGGGGGGCAAATAAGACCCCACCCCTCCCTGCAGCTTCACAG
GGACGCTTCCTTCCCTCCCCGCAACCACCCCAGGCTCCCCTGGGAGGCTGCAGTTGTGGTACACGTCCCCGGTGCTGGGTTGGCCGTGAC

>59416_59416_8_NME2-ACBD4_NME2_chr17_49244317_ENST00000555572_ACBD4_chr17_43216388_ENST00000586346_length(amino acids)=294AA_BP=182
MVLLSTLGIVFQGEGPPISSCDTGTMANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLV
KYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKF
LRRGCGAARRGPRSWTCGCWGQFEHYRRACRRCRRGCRAWRACPGPLSRGRSPGPVLGHGPLGSRGPRCSSSSCGPSSSSGSSECFGPKR

--------------------------------------------------------------
>59416_59416_9_NME2-ACBD4_NME2_chr17_49244317_ENST00000555572_ACBD4_chr17_43216388_ENST00000591859_length(transcript)=1596nt_BP=722nt
GGAGTTCAAACCTAAGCAGCTGGAAGGGCCCTGTGGCTAGGTACCATAGAGTCTCTACACAGGACTAAGTCAGCCTGGTGTGCAGGGGAG
GCAGACACACAAACAGAAAATTGGACTACAGTGCTAAGATGCTGTAAGAAGAGGTTAACTAAAGGACAGGAAGATGGGGCCAAGAGATGG
TGCTACTGTCTACTTTAGGGATCGTCTTTCAAGGCGAGGGGCCTCCTATCTCAAGCTGTGATACAGGAACCATGGCCAACTGTGAGCGTA
CCTTCATTGCGATCAAACCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGATTCCGCCTTGTTG
GTCTGAAATTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGGTGAAAT
ACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAACCCTG
CAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTCATCGCCATCA
AGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGTTCCTCC
GGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTCGAGCACTACAGGAGAGCATGCAGGA
GGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGAGGCCGCAGCCCAGGCCCAGTGCTCGGCCATGGCCCCT
TGGGCTCCCGGGGCCCGCGCTGCTCTTCTTCCTCCTGTGGCCCTTCGTCGTCCAGTGGCTCTTCCGAATGTTTCGGACCCAAAAGAGGTG
ACTGTCAGTGGAGGGGTCTCTGCAGCCAACTGAGACTATCTTGCTGTGCCCTGAGCCTTCCTAGGGTTTAGAAGAACAGCATTCAAAATT
CCCCGTCCTGTCAGTGTTTGCCTTCGCACCTCCTCCCCTAAAGCAGCGCGGGGGGCAAATAAGACCCCACCCCTCCCTGCAGCTTCACAG
GGACGCTTCCTTCCCTCCCCGCAACCACCCCAGGCTCCCCTGGGAGGCTGCAGTTGTGGTACACGTCCCCGGTGCTGGGTTGGCCGTGAC
TCGGGGGCGGGGCGATCGGGTCTCAGCCCCTGCCTTCCCCAGTCTCTGGGTCACCCGAATTTTCCCACCCCTGCTTCTCCCCGAGGAGGT
TGAGCTCTTGAGCAAGTTGGGACTTGGGCCGGGGCCTGGAAGAATGATTGGCTGGGAGGCCGCGGGAGGGAGGCCAGGAGGCCCGGACCA
GTTGGGAGGAGTGAGCAGGCCCCGGGGGAGGGGGATGAGCGCAGTTTGCTCGCTTTCCTCCCCTGCCGGCCCCCTCCGCCCCCACACACA

>59416_59416_9_NME2-ACBD4_NME2_chr17_49244317_ENST00000555572_ACBD4_chr17_43216388_ENST00000591859_length(amino acids)=294AA_BP=182
MVLLSTLGIVFQGEGPPISSCDTGTMANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLV
KYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKF
LRRGCGAARRGPRSWTCGCWGQFEHYRRACRRCRRGCRAWRACPGPLSRGRSPGPVLGHGPLGSRGPRCSSSSCGPSSSSGSSECFGPKR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NME2-ACBD4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneNME2chr17:49244317chr17:43216388ENST00000393193+581_66157.0268.0AKAP13


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NME2-ACBD4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NME2-ACBD4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource