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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NMNAT3-RBP1 (FusionGDB2 ID:59447)

Fusion Gene Summary for NMNAT3-RBP1

check button Fusion gene summary
Fusion gene informationFusion gene name: NMNAT3-RBP1
Fusion gene ID: 59447
HgeneTgene
Gene symbol

NMNAT3

RBP1

Gene ID

349565

5947

Gene namenicotinamide nucleotide adenylyltransferase 3retinol binding protein 1
SynonymsFKSG76|PNAT-3|PNAT3CRABP-I|CRBP|CRBP1|CRBPI|RBPC
Cytomap

3q23

3q23

Type of geneprotein-codingprotein-coding
Descriptionnicotinamide/nicotinic acid mononucleotide adenylyltransferase 3NMN adenylyltransferase 3NMN/NaMN adenylyltransferase 3NaMN adenylyltransferase 3nicotinamide mononucleotide adenylyltransferase 3nicotinate-nucleotide adenylyltransferase 3pyridine nucretinol-binding protein 1CRBP-Icellular retinol binding protein 1cellular retinol-binding protein Iretinol-binding protein 1, cellular
Modification date2020031320200313
UniProtAcc

Q96T66

.
Ensembl transtripts involved in fusion geneENST00000296202, ENST00000413939, 
ENST00000512391, ENST00000514703, 
ENST00000406164, ENST00000406824, 
ENST00000339837, ENST00000507242, 
ENST00000511444, 		ENST00000483943, 
ENST00000492918, ENST00000232219, 
Fusion gene scores* DoF score4 X 3 X 3=364 X 3 X 3=36
# samples 56
** MAII scorelog2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/36*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NMNAT3 [Title/Abstract] AND RBP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNMNAT3(139346457)-RBP1(139237364), # samples:1
NMNAT3(139346458)-RBP1(139237364), # samples:1
RBP1(139237263)-NMNAT3(139297897), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NMNAT3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RBP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-2261-01ANMNAT3chr3

139346458

-RBP1chr3

139237364

-
ChimerDB4OVTCGA-24-2261NMNAT3chr3

139346457

-RBP1chr3

139237364

-


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Fusion Gene ORF analysis for NMNAT3-RBP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000296202ENST00000483943NMNAT3chr3

139346458

-RBP1chr3

139237364

-
5CDS-intronENST00000296202ENST00000483943NMNAT3chr3

139346457

-RBP1chr3

139237364

-
5CDS-intronENST00000296202ENST00000492918NMNAT3chr3

139346458

-RBP1chr3

139237364

-
5CDS-intronENST00000296202ENST00000492918NMNAT3chr3

139346457

-RBP1chr3

139237364

-
5CDS-intronENST00000413939ENST00000483943NMNAT3chr3

139346458

-RBP1chr3

139237364

-
5CDS-intronENST00000413939ENST00000483943NMNAT3chr3

139346457

-RBP1chr3

139237364

-
5CDS-intronENST00000413939ENST00000492918NMNAT3chr3

139346458

-RBP1chr3

139237364

-
5CDS-intronENST00000413939ENST00000492918NMNAT3chr3

139346457

-RBP1chr3

139237364

-
5CDS-intronENST00000512391ENST00000483943NMNAT3chr3

139346458

-RBP1chr3

139237364

-
5CDS-intronENST00000512391ENST00000483943NMNAT3chr3

139346457

-RBP1chr3

139237364

-
5CDS-intronENST00000512391ENST00000492918NMNAT3chr3

139346458

-RBP1chr3

139237364

-
5CDS-intronENST00000512391ENST00000492918NMNAT3chr3

139346457

-RBP1chr3

139237364

-
5CDS-intronENST00000514703ENST00000483943NMNAT3chr3

139346458

-RBP1chr3

139237364

-
5CDS-intronENST00000514703ENST00000483943NMNAT3chr3

139346457

-RBP1chr3

139237364

-
5CDS-intronENST00000514703ENST00000492918NMNAT3chr3

139346458

-RBP1chr3

139237364

-
5CDS-intronENST00000514703ENST00000492918NMNAT3chr3

139346457

-RBP1chr3

139237364

-
5UTR-3CDSENST00000406164ENST00000232219NMNAT3chr3

139346458

-RBP1chr3

139237364

-
5UTR-3CDSENST00000406164ENST00000232219NMNAT3chr3

139346457

-RBP1chr3

139237364

-
5UTR-3CDSENST00000406824ENST00000232219NMNAT3chr3

139346458

-RBP1chr3

139237364

-
5UTR-3CDSENST00000406824ENST00000232219NMNAT3chr3

139346457

-RBP1chr3

139237364

-
5UTR-intronENST00000406164ENST00000483943NMNAT3chr3

139346458

-RBP1chr3

139237364

-
5UTR-intronENST00000406164ENST00000483943NMNAT3chr3

139346457

-RBP1chr3

139237364

-
5UTR-intronENST00000406164ENST00000492918NMNAT3chr3

139346458

-RBP1chr3

139237364

-
5UTR-intronENST00000406164ENST00000492918NMNAT3chr3

139346457

-RBP1chr3

139237364

-
5UTR-intronENST00000406824ENST00000483943NMNAT3chr3

139346458

-RBP1chr3

139237364

-
5UTR-intronENST00000406824ENST00000483943NMNAT3chr3

139346457

-RBP1chr3

139237364

-
5UTR-intronENST00000406824ENST00000492918NMNAT3chr3

139346458

-RBP1chr3

139237364

-
5UTR-intronENST00000406824ENST00000492918NMNAT3chr3

139346457

-RBP1chr3

139237364

-
In-frameENST00000296202ENST00000232219NMNAT3chr3

139346458

-RBP1chr3

139237364

-
In-frameENST00000296202ENST00000232219NMNAT3chr3

139346457

-RBP1chr3

139237364

-
In-frameENST00000413939ENST00000232219NMNAT3chr3

139346458

-RBP1chr3

139237364

-
In-frameENST00000413939ENST00000232219NMNAT3chr3

139346457

-RBP1chr3

139237364

-
In-frameENST00000512391ENST00000232219NMNAT3chr3

139346458

-RBP1chr3

139237364

-
In-frameENST00000512391ENST00000232219NMNAT3chr3

139346457

-RBP1chr3

139237364

-
In-frameENST00000514703ENST00000232219NMNAT3chr3

139346458

-RBP1chr3

139237364

-
In-frameENST00000514703ENST00000232219NMNAT3chr3

139346457

-RBP1chr3

139237364

-
intron-3CDSENST00000339837ENST00000232219NMNAT3chr3

139346458

-RBP1chr3

139237364

-
intron-3CDSENST00000339837ENST00000232219NMNAT3chr3

139346457

-RBP1chr3

139237364

-
intron-3CDSENST00000507242ENST00000232219NMNAT3chr3

139346458

-RBP1chr3

139237364

-
intron-3CDSENST00000507242ENST00000232219NMNAT3chr3

139346457

-RBP1chr3

139237364

-
intron-3CDSENST00000511444ENST00000232219NMNAT3chr3

139346458

-RBP1chr3

139237364

-
intron-3CDSENST00000511444ENST00000232219NMNAT3chr3

139346457

-RBP1chr3

139237364

-
intron-intronENST00000339837ENST00000483943NMNAT3chr3

139346458

-RBP1chr3

139237364

-
intron-intronENST00000339837ENST00000483943NMNAT3chr3

139346457

-RBP1chr3

139237364

-
intron-intronENST00000339837ENST00000492918NMNAT3chr3

139346458

-RBP1chr3

139237364

-
intron-intronENST00000339837ENST00000492918NMNAT3chr3

139346457

-RBP1chr3

139237364

-
intron-intronENST00000507242ENST00000483943NMNAT3chr3

139346458

-RBP1chr3

139237364

-
intron-intronENST00000507242ENST00000483943NMNAT3chr3

139346457

-RBP1chr3

139237364

-
intron-intronENST00000507242ENST00000492918NMNAT3chr3

139346458

-RBP1chr3

139237364

-
intron-intronENST00000507242ENST00000492918NMNAT3chr3

139346457

-RBP1chr3

139237364

-
intron-intronENST00000511444ENST00000483943NMNAT3chr3

139346458

-RBP1chr3

139237364

-
intron-intronENST00000511444ENST00000483943NMNAT3chr3

139346457

-RBP1chr3

139237364

-
intron-intronENST00000511444ENST00000492918NMNAT3chr3

139346458

-RBP1chr3

139237364

-
intron-intronENST00000511444ENST00000492918NMNAT3chr3

139346457

-RBP1chr3

139237364

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000413939NMNAT3chr3139346457-ENST00000232219RBP1chr3139237364-85951076949790
ENST00000296202NMNAT3chr3139346457-ENST00000232219RBP1chr3139237364-84049175047890
ENST00000512391NMNAT3chr3139346457-ENST00000232219RBP1chr3139237364-89955080953790
ENST00000514703NMNAT3chr3139346457-ENST00000232219RBP1chr3139237364-61226352225090
ENST00000413939NMNAT3chr3139346458-ENST00000232219RBP1chr3139237364-85951076949790
ENST00000296202NMNAT3chr3139346458-ENST00000232219RBP1chr3139237364-84049175047890
ENST00000512391NMNAT3chr3139346458-ENST00000232219RBP1chr3139237364-89955080953790
ENST00000514703NMNAT3chr3139346458-ENST00000232219RBP1chr3139237364-61226352225090

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000413939ENST00000232219NMNAT3chr3139346457-RBP1chr3139237364-0.627431150.37256888
ENST00000296202ENST00000232219NMNAT3chr3139346457-RBP1chr3139237364-0.693627660.30637234
ENST00000512391ENST00000232219NMNAT3chr3139346457-RBP1chr3139237364-0.51647110.4835289
ENST00000514703ENST00000232219NMNAT3chr3139346457-RBP1chr3139237364-0.52085660.47914344
ENST00000413939ENST00000232219NMNAT3chr3139346458-RBP1chr3139237364-0.627431150.37256888
ENST00000296202ENST00000232219NMNAT3chr3139346458-RBP1chr3139237364-0.693627660.30637234
ENST00000512391ENST00000232219NMNAT3chr3139346458-RBP1chr3139237364-0.51647110.4835289
ENST00000514703ENST00000232219NMNAT3chr3139346458-RBP1chr3139237364-0.52085660.47914344

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Fusion Genomic Features for NMNAT3-RBP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NMNAT3-RBP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:139346457/chr3:139237364)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NMNAT3

Q96T66

.
FUNCTION: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. {ECO:0000269|PubMed:16118205, ECO:0000269|PubMed:17402747}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNMNAT3chr3:139346457chr3:139237364ENST00000296202-3613_1536253.0Nucleotide bindingATP
HgeneNMNAT3chr3:139346457chr3:139237364ENST00000413939-3413_1536164.0Nucleotide bindingATP
HgeneNMNAT3chr3:139346458chr3:139237364ENST00000296202-3613_1536253.0Nucleotide bindingATP
HgeneNMNAT3chr3:139346458chr3:139237364ENST00000413939-3413_1536164.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNMNAT3chr3:139346457chr3:139237364ENST00000296202-36135_13736253.0Nucleotide bindingATP
HgeneNMNAT3chr3:139346457chr3:139237364ENST00000296202-36203_20636253.0Nucleotide bindingATP
HgeneNMNAT3chr3:139346457chr3:139237364ENST00000339837-15135_1370216.0Nucleotide bindingATP
HgeneNMNAT3chr3:139346457chr3:139237364ENST00000339837-1513_150216.0Nucleotide bindingATP
HgeneNMNAT3chr3:139346457chr3:139237364ENST00000339837-15203_2060216.0Nucleotide bindingATP
HgeneNMNAT3chr3:139346457chr3:139237364ENST00000406164-36135_1370216.0Nucleotide bindingATP
HgeneNMNAT3chr3:139346457chr3:139237364ENST00000406164-3613_150216.0Nucleotide bindingATP
HgeneNMNAT3chr3:139346457chr3:139237364ENST00000406164-36203_2060216.0Nucleotide bindingATP
HgeneNMNAT3chr3:139346457chr3:139237364ENST00000413939-34135_13736164.0Nucleotide bindingATP
HgeneNMNAT3chr3:139346457chr3:139237364ENST00000413939-34203_20636164.0Nucleotide bindingATP
HgeneNMNAT3chr3:139346458chr3:139237364ENST00000296202-36135_13736253.0Nucleotide bindingATP
HgeneNMNAT3chr3:139346458chr3:139237364ENST00000296202-36203_20636253.0Nucleotide bindingATP
HgeneNMNAT3chr3:139346458chr3:139237364ENST00000339837-15135_1370216.0Nucleotide bindingATP
HgeneNMNAT3chr3:139346458chr3:139237364ENST00000339837-1513_150216.0Nucleotide bindingATP
HgeneNMNAT3chr3:139346458chr3:139237364ENST00000339837-15203_2060216.0Nucleotide bindingATP
HgeneNMNAT3chr3:139346458chr3:139237364ENST00000406164-36135_1370216.0Nucleotide bindingATP
HgeneNMNAT3chr3:139346458chr3:139237364ENST00000406164-3613_150216.0Nucleotide bindingATP
HgeneNMNAT3chr3:139346458chr3:139237364ENST00000406164-36203_2060216.0Nucleotide bindingATP
HgeneNMNAT3chr3:139346458chr3:139237364ENST00000413939-34135_13736164.0Nucleotide bindingATP
HgeneNMNAT3chr3:139346458chr3:139237364ENST00000413939-34203_20636164.0Nucleotide bindingATP
HgeneNMNAT3chr3:139346457chr3:139237364ENST00000296202-36147_14836253.0RegionSubstrate binding
HgeneNMNAT3chr3:139346457chr3:139237364ENST00000296202-3653_5536253.0RegionSubstrate binding
HgeneNMNAT3chr3:139346457chr3:139237364ENST00000296202-3690_9336253.0RegionSubstrate binding
HgeneNMNAT3chr3:139346457chr3:139237364ENST00000339837-15147_1480216.0RegionSubstrate binding
HgeneNMNAT3chr3:139346457chr3:139237364ENST00000339837-1553_550216.0RegionSubstrate binding
HgeneNMNAT3chr3:139346457chr3:139237364ENST00000339837-1590_930216.0RegionSubstrate binding
HgeneNMNAT3chr3:139346457chr3:139237364ENST00000406164-36147_1480216.0RegionSubstrate binding
HgeneNMNAT3chr3:139346457chr3:139237364ENST00000406164-3653_550216.0RegionSubstrate binding
HgeneNMNAT3chr3:139346457chr3:139237364ENST00000406164-3690_930216.0RegionSubstrate binding
HgeneNMNAT3chr3:139346457chr3:139237364ENST00000413939-34147_14836164.0RegionSubstrate binding
HgeneNMNAT3chr3:139346457chr3:139237364ENST00000413939-3453_5536164.0RegionSubstrate binding
HgeneNMNAT3chr3:139346457chr3:139237364ENST00000413939-3490_9336164.0RegionSubstrate binding
HgeneNMNAT3chr3:139346458chr3:139237364ENST00000296202-36147_14836253.0RegionSubstrate binding
HgeneNMNAT3chr3:139346458chr3:139237364ENST00000296202-3653_5536253.0RegionSubstrate binding
HgeneNMNAT3chr3:139346458chr3:139237364ENST00000296202-3690_9336253.0RegionSubstrate binding
HgeneNMNAT3chr3:139346458chr3:139237364ENST00000339837-15147_1480216.0RegionSubstrate binding
HgeneNMNAT3chr3:139346458chr3:139237364ENST00000339837-1553_550216.0RegionSubstrate binding
HgeneNMNAT3chr3:139346458chr3:139237364ENST00000339837-1590_930216.0RegionSubstrate binding
HgeneNMNAT3chr3:139346458chr3:139237364ENST00000406164-36147_1480216.0RegionSubstrate binding
HgeneNMNAT3chr3:139346458chr3:139237364ENST00000406164-3653_550216.0RegionSubstrate binding
HgeneNMNAT3chr3:139346458chr3:139237364ENST00000406164-3690_930216.0RegionSubstrate binding
HgeneNMNAT3chr3:139346458chr3:139237364ENST00000413939-34147_14836164.0RegionSubstrate binding
HgeneNMNAT3chr3:139346458chr3:139237364ENST00000413939-3453_5536164.0RegionSubstrate binding
HgeneNMNAT3chr3:139346458chr3:139237364ENST00000413939-3490_9336164.0RegionSubstrate binding


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Fusion Gene Sequence for NMNAT3-RBP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>59447_59447_1_NMNAT3-RBP1_NMNAT3_chr3_139346457_ENST00000296202_RBP1_chr3_139237364_ENST00000232219_length(transcript)=840nt_BP=491nt
GGGAGCGCAAGGTCAAGTTCGCCTTGGCCCCGCCTCCAGCTCAGGTACTAGGGGATCTAGACCTGAGGCTGCCCGGGCCGGAGGCAGCCT
TGAGTCCCGAGACCAAACGTCGTTTCCCTCTCGGACCTCGGGCGCCGGGCCGCGCGCTGACCGACAGCCCCTGCTAGGCCCAGCAGGTCC
CCTAGTCCCCCGCAGTCCCCCGAGACTCGCCGAGCGCCGTTGCTGAGCCCTGCAAATAGCAGCTACCTGCTTCAGCCTAGATCCTGCCAT
GAAGCGGACTGCTGCTCCCTGGCTCCCACTCTGATCTGCTTTTCACTCTTGCCTTGTCTCCCAATTAATAAGCAGGGTGGCCACTGCAAC
AGGTGTGGATGTGCCTGACAAGATGAAGAGCCGAATACCTGTGGTGCTCCTGGCCTGTGGCTCCTTTAACCCCATCACCAACATGCACCT
GCGCATGTTTGAGGTGGCCAGAGATCACCTACACCAAACAGACAACAGTGAGCTGGGACGGAGACAAGCTCCAGTGTGTGCAGAAGGGTG
AGAAGGAGGGGCGTGGCTGGACCCAGTGGATCGAGGGTGATGAGCTGCACCTGGAGATGAGAGTGGAAGGTGTGGTCTGCAAGCAAGTAT
TCAAGAAGGTGCAGTGAGGCCCAGGCAGACAACCTTGTCCCAAGGAATCAGCAGGATGTGTGGGCCAGGATCCCCCTCTTTGCACAGCAT
GAGGCAAAAATGTCCAGCCACCCCCAGGCATCTGTTAGCAGAGTCTGTCTCTTGGCTTTGTCACTTTTCCTTTTCTTAAAACAAAGCCAT

>59447_59447_1_NMNAT3-RBP1_NMNAT3_chr3_139346457_ENST00000296202_RBP1_chr3_139237364_ENST00000232219_length(amino acids)=90AA_BP=0
MPGGGWTFLPHAVQRGGSWPTHPADSLGQGCLPGPHCTFLNTCLQTTPSTLISRCSSSPSIHWVQPRPSFSPFCTHWSLSPSQLTVVCLV

--------------------------------------------------------------
>59447_59447_2_NMNAT3-RBP1_NMNAT3_chr3_139346457_ENST00000413939_RBP1_chr3_139237364_ENST00000232219_length(transcript)=859nt_BP=510nt
ATCTGCCCGGGGCCGCTAAGGGAGCGCAAGGTCAAGTTCGCCTTGGCCCCGCCTCCAGCTCAGGTACTAGGGGATCTAGACCTGAGGCTG
CCCGGGCCGGAGGCAGCCTTGAGTCCCGAGACCAAACGTCGTTTCCCTCTCGGACCTCGGGCGCCGGGCCGCGCGCTGACCGACAGCCCC
TGCTAGGCCCAGCAGGTCCCCTAGTCCCCCGCAGTCCCCCGAGACTCGCCGAGCGCCGTTGCTGAGCCCTGCAAATAGCAGCTACCTGCT
TCAGCCTAGATCCTGCCATGAAGCGGACTGCTGCTCCCTGGCTCCCACTCTGATCTGCTTTTCACTCTTGCCTTGTCTCCCAATTAATAA
GCAGGGTGGCCACTGCAACAGGTGTGGATGTGCCTGACAAGATGAAGAGCCGAATACCTGTGGTGCTCCTGGCCTGTGGCTCCTTTAACC
CCATCACCAACATGCACCTGCGCATGTTTGAGGTGGCCAGAGATCACCTACACCAAACAGACAACAGTGAGCTGGGACGGAGACAAGCTC
CAGTGTGTGCAGAAGGGTGAGAAGGAGGGGCGTGGCTGGACCCAGTGGATCGAGGGTGATGAGCTGCACCTGGAGATGAGAGTGGAAGGT
GTGGTCTGCAAGCAAGTATTCAAGAAGGTGCAGTGAGGCCCAGGCAGACAACCTTGTCCCAAGGAATCAGCAGGATGTGTGGGCCAGGAT
CCCCCTCTTTGCACAGCATGAGGCAAAAATGTCCAGCCACCCCCAGGCATCTGTTAGCAGAGTCTGTCTCTTGGCTTTGTCACTTTTCCT

>59447_59447_2_NMNAT3-RBP1_NMNAT3_chr3_139346457_ENST00000413939_RBP1_chr3_139237364_ENST00000232219_length(amino acids)=90AA_BP=0
MPGGGWTFLPHAVQRGGSWPTHPADSLGQGCLPGPHCTFLNTCLQTTPSTLISRCSSSPSIHWVQPRPSFSPFCTHWSLSPSQLTVVCLV

--------------------------------------------------------------
>59447_59447_3_NMNAT3-RBP1_NMNAT3_chr3_139346457_ENST00000512391_RBP1_chr3_139237364_ENST00000232219_length(transcript)=899nt_BP=550nt
AGCGAAGGGGCGGGGCGCAGATCTGTTTCCCTCAGACTCCATCTGCCCGGGGCCGCTAAGGGAGCGCAAGGTCAAGTTCGCCTTGGCCCC
GCCTCCAGCTCAGGTACTAGGGGATCTAGACCTGAGGCTGCCCGGGCCGGAGGCAGCCTTGAGTCCCGAGACCAAACGTCGTTTCCCTCT
CGGACCTCGGGCGCCGGGCCGCGCGCTGACCGACAGCCCCTGCTAGGCCCAGCAGGTCCCCTAGTCCCCCGCAGTCCCCCGAGACTCGCC
GAGCGCCGTTGCTGAGCCCTGCAAATAGCAGCTACCTGCTTCAGCCTAGATCCTGCCATGAAGCGGACTGCTGCTCCCTGGCTCCCACTC
TGATCTGCTTTTCACTCTTGCCTTGTCTCCCAATTAATAAGCAGGGTGGCCACTGCAACAGGTGTGGATGTGCCTGACAAGATGAAGAGC
CGAATACCTGTGGTGCTCCTGGCCTGTGGCTCCTTTAACCCCATCACCAACATGCACCTGCGCATGTTTGAGGTGGCCAGAGATCACCTA
CACCAAACAGACAACAGTGAGCTGGGACGGAGACAAGCTCCAGTGTGTGCAGAAGGGTGAGAAGGAGGGGCGTGGCTGGACCCAGTGGAT
CGAGGGTGATGAGCTGCACCTGGAGATGAGAGTGGAAGGTGTGGTCTGCAAGCAAGTATTCAAGAAGGTGCAGTGAGGCCCAGGCAGACA
ACCTTGTCCCAAGGAATCAGCAGGATGTGTGGGCCAGGATCCCCCTCTTTGCACAGCATGAGGCAAAAATGTCCAGCCACCCCCAGGCAT

>59447_59447_3_NMNAT3-RBP1_NMNAT3_chr3_139346457_ENST00000512391_RBP1_chr3_139237364_ENST00000232219_length(amino acids)=90AA_BP=0
MPGGGWTFLPHAVQRGGSWPTHPADSLGQGCLPGPHCTFLNTCLQTTPSTLISRCSSSPSIHWVQPRPSFSPFCTHWSLSPSQLTVVCLV

--------------------------------------------------------------
>59447_59447_4_NMNAT3-RBP1_NMNAT3_chr3_139346457_ENST00000514703_RBP1_chr3_139237364_ENST00000232219_length(transcript)=612nt_BP=263nt
CCTGCAAATAGCAGCTACCTGCTTCAGCCTAGATCCTGCCATGAAGCGGACTGCTGCTCCCTGGCTCCCACTCTGATCTGCTTTTCACTC
TTGCCTTGTCTCCCAATTAATAAGCAGGGTGGCCACTGCAACAGGTGTGGATGTGCCTGACAAGATGAAGAGCCGAATACCTGTGGTGCT
CCTGGCCTGTGGCTCCTTTAACCCCATCACCAACATGCACCTGCGCATGTTTGAGGTGGCCAGAGATCACCTACACCAAACAGACAACAG
TGAGCTGGGACGGAGACAAGCTCCAGTGTGTGCAGAAGGGTGAGAAGGAGGGGCGTGGCTGGACCCAGTGGATCGAGGGTGATGAGCTGC
ACCTGGAGATGAGAGTGGAAGGTGTGGTCTGCAAGCAAGTATTCAAGAAGGTGCAGTGAGGCCCAGGCAGACAACCTTGTCCCAAGGAAT
CAGCAGGATGTGTGGGCCAGGATCCCCCTCTTTGCACAGCATGAGGCAAAAATGTCCAGCCACCCCCAGGCATCTGTTAGCAGAGTCTGT

>59447_59447_4_NMNAT3-RBP1_NMNAT3_chr3_139346457_ENST00000514703_RBP1_chr3_139237364_ENST00000232219_length(amino acids)=90AA_BP=0
MPGGGWTFLPHAVQRGGSWPTHPADSLGQGCLPGPHCTFLNTCLQTTPSTLISRCSSSPSIHWVQPRPSFSPFCTHWSLSPSQLTVVCLV

--------------------------------------------------------------
>59447_59447_5_NMNAT3-RBP1_NMNAT3_chr3_139346458_ENST00000296202_RBP1_chr3_139237364_ENST00000232219_length(transcript)=840nt_BP=491nt
GGGAGCGCAAGGTCAAGTTCGCCTTGGCCCCGCCTCCAGCTCAGGTACTAGGGGATCTAGACCTGAGGCTGCCCGGGCCGGAGGCAGCCT
TGAGTCCCGAGACCAAACGTCGTTTCCCTCTCGGACCTCGGGCGCCGGGCCGCGCGCTGACCGACAGCCCCTGCTAGGCCCAGCAGGTCC
CCTAGTCCCCCGCAGTCCCCCGAGACTCGCCGAGCGCCGTTGCTGAGCCCTGCAAATAGCAGCTACCTGCTTCAGCCTAGATCCTGCCAT
GAAGCGGACTGCTGCTCCCTGGCTCCCACTCTGATCTGCTTTTCACTCTTGCCTTGTCTCCCAATTAATAAGCAGGGTGGCCACTGCAAC
AGGTGTGGATGTGCCTGACAAGATGAAGAGCCGAATACCTGTGGTGCTCCTGGCCTGTGGCTCCTTTAACCCCATCACCAACATGCACCT
GCGCATGTTTGAGGTGGCCAGAGATCACCTACACCAAACAGACAACAGTGAGCTGGGACGGAGACAAGCTCCAGTGTGTGCAGAAGGGTG
AGAAGGAGGGGCGTGGCTGGACCCAGTGGATCGAGGGTGATGAGCTGCACCTGGAGATGAGAGTGGAAGGTGTGGTCTGCAAGCAAGTAT
TCAAGAAGGTGCAGTGAGGCCCAGGCAGACAACCTTGTCCCAAGGAATCAGCAGGATGTGTGGGCCAGGATCCCCCTCTTTGCACAGCAT
GAGGCAAAAATGTCCAGCCACCCCCAGGCATCTGTTAGCAGAGTCTGTCTCTTGGCTTTGTCACTTTTCCTTTTCTTAAAACAAAGCCAT

>59447_59447_5_NMNAT3-RBP1_NMNAT3_chr3_139346458_ENST00000296202_RBP1_chr3_139237364_ENST00000232219_length(amino acids)=90AA_BP=0
MPGGGWTFLPHAVQRGGSWPTHPADSLGQGCLPGPHCTFLNTCLQTTPSTLISRCSSSPSIHWVQPRPSFSPFCTHWSLSPSQLTVVCLV

--------------------------------------------------------------
>59447_59447_6_NMNAT3-RBP1_NMNAT3_chr3_139346458_ENST00000413939_RBP1_chr3_139237364_ENST00000232219_length(transcript)=859nt_BP=510nt
ATCTGCCCGGGGCCGCTAAGGGAGCGCAAGGTCAAGTTCGCCTTGGCCCCGCCTCCAGCTCAGGTACTAGGGGATCTAGACCTGAGGCTG
CCCGGGCCGGAGGCAGCCTTGAGTCCCGAGACCAAACGTCGTTTCCCTCTCGGACCTCGGGCGCCGGGCCGCGCGCTGACCGACAGCCCC
TGCTAGGCCCAGCAGGTCCCCTAGTCCCCCGCAGTCCCCCGAGACTCGCCGAGCGCCGTTGCTGAGCCCTGCAAATAGCAGCTACCTGCT
TCAGCCTAGATCCTGCCATGAAGCGGACTGCTGCTCCCTGGCTCCCACTCTGATCTGCTTTTCACTCTTGCCTTGTCTCCCAATTAATAA
GCAGGGTGGCCACTGCAACAGGTGTGGATGTGCCTGACAAGATGAAGAGCCGAATACCTGTGGTGCTCCTGGCCTGTGGCTCCTTTAACC
CCATCACCAACATGCACCTGCGCATGTTTGAGGTGGCCAGAGATCACCTACACCAAACAGACAACAGTGAGCTGGGACGGAGACAAGCTC
CAGTGTGTGCAGAAGGGTGAGAAGGAGGGGCGTGGCTGGACCCAGTGGATCGAGGGTGATGAGCTGCACCTGGAGATGAGAGTGGAAGGT
GTGGTCTGCAAGCAAGTATTCAAGAAGGTGCAGTGAGGCCCAGGCAGACAACCTTGTCCCAAGGAATCAGCAGGATGTGTGGGCCAGGAT
CCCCCTCTTTGCACAGCATGAGGCAAAAATGTCCAGCCACCCCCAGGCATCTGTTAGCAGAGTCTGTCTCTTGGCTTTGTCACTTTTCCT

>59447_59447_6_NMNAT3-RBP1_NMNAT3_chr3_139346458_ENST00000413939_RBP1_chr3_139237364_ENST00000232219_length(amino acids)=90AA_BP=0
MPGGGWTFLPHAVQRGGSWPTHPADSLGQGCLPGPHCTFLNTCLQTTPSTLISRCSSSPSIHWVQPRPSFSPFCTHWSLSPSQLTVVCLV

--------------------------------------------------------------
>59447_59447_7_NMNAT3-RBP1_NMNAT3_chr3_139346458_ENST00000512391_RBP1_chr3_139237364_ENST00000232219_length(transcript)=899nt_BP=550nt
AGCGAAGGGGCGGGGCGCAGATCTGTTTCCCTCAGACTCCATCTGCCCGGGGCCGCTAAGGGAGCGCAAGGTCAAGTTCGCCTTGGCCCC
GCCTCCAGCTCAGGTACTAGGGGATCTAGACCTGAGGCTGCCCGGGCCGGAGGCAGCCTTGAGTCCCGAGACCAAACGTCGTTTCCCTCT
CGGACCTCGGGCGCCGGGCCGCGCGCTGACCGACAGCCCCTGCTAGGCCCAGCAGGTCCCCTAGTCCCCCGCAGTCCCCCGAGACTCGCC
GAGCGCCGTTGCTGAGCCCTGCAAATAGCAGCTACCTGCTTCAGCCTAGATCCTGCCATGAAGCGGACTGCTGCTCCCTGGCTCCCACTC
TGATCTGCTTTTCACTCTTGCCTTGTCTCCCAATTAATAAGCAGGGTGGCCACTGCAACAGGTGTGGATGTGCCTGACAAGATGAAGAGC
CGAATACCTGTGGTGCTCCTGGCCTGTGGCTCCTTTAACCCCATCACCAACATGCACCTGCGCATGTTTGAGGTGGCCAGAGATCACCTA
CACCAAACAGACAACAGTGAGCTGGGACGGAGACAAGCTCCAGTGTGTGCAGAAGGGTGAGAAGGAGGGGCGTGGCTGGACCCAGTGGAT
CGAGGGTGATGAGCTGCACCTGGAGATGAGAGTGGAAGGTGTGGTCTGCAAGCAAGTATTCAAGAAGGTGCAGTGAGGCCCAGGCAGACA
ACCTTGTCCCAAGGAATCAGCAGGATGTGTGGGCCAGGATCCCCCTCTTTGCACAGCATGAGGCAAAAATGTCCAGCCACCCCCAGGCAT

>59447_59447_7_NMNAT3-RBP1_NMNAT3_chr3_139346458_ENST00000512391_RBP1_chr3_139237364_ENST00000232219_length(amino acids)=90AA_BP=0
MPGGGWTFLPHAVQRGGSWPTHPADSLGQGCLPGPHCTFLNTCLQTTPSTLISRCSSSPSIHWVQPRPSFSPFCTHWSLSPSQLTVVCLV

--------------------------------------------------------------
>59447_59447_8_NMNAT3-RBP1_NMNAT3_chr3_139346458_ENST00000514703_RBP1_chr3_139237364_ENST00000232219_length(transcript)=612nt_BP=263nt
CCTGCAAATAGCAGCTACCTGCTTCAGCCTAGATCCTGCCATGAAGCGGACTGCTGCTCCCTGGCTCCCACTCTGATCTGCTTTTCACTC
TTGCCTTGTCTCCCAATTAATAAGCAGGGTGGCCACTGCAACAGGTGTGGATGTGCCTGACAAGATGAAGAGCCGAATACCTGTGGTGCT
CCTGGCCTGTGGCTCCTTTAACCCCATCACCAACATGCACCTGCGCATGTTTGAGGTGGCCAGAGATCACCTACACCAAACAGACAACAG
TGAGCTGGGACGGAGACAAGCTCCAGTGTGTGCAGAAGGGTGAGAAGGAGGGGCGTGGCTGGACCCAGTGGATCGAGGGTGATGAGCTGC
ACCTGGAGATGAGAGTGGAAGGTGTGGTCTGCAAGCAAGTATTCAAGAAGGTGCAGTGAGGCCCAGGCAGACAACCTTGTCCCAAGGAAT
CAGCAGGATGTGTGGGCCAGGATCCCCCTCTTTGCACAGCATGAGGCAAAAATGTCCAGCCACCCCCAGGCATCTGTTAGCAGAGTCTGT

>59447_59447_8_NMNAT3-RBP1_NMNAT3_chr3_139346458_ENST00000514703_RBP1_chr3_139237364_ENST00000232219_length(amino acids)=90AA_BP=0
MPGGGWTFLPHAVQRGGSWPTHPADSLGQGCLPGPHCTFLNTCLQTTPSTLISRCSSSPSIHWVQPRPSFSPFCTHWSLSPSQLTVVCLV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NMNAT3-RBP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NMNAT3-RBP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NMNAT3-RBP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource