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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NMRK2-CELF2 (FusionGDB2 ID:59463)

Fusion Gene Summary for NMRK2-CELF2

check button Fusion gene summary
Fusion gene informationFusion gene name: NMRK2-CELF2
Fusion gene ID: 59463
HgeneTgene
Gene symbol

NMRK2

CELF2

Gene ID

27231

10659

Gene namenicotinamide riboside kinase 2CUGBP Elav-like family member 2
SynonymsITGB1BP3|MIBP|NRK2BRUNOL3|CELF-2|CUG-BP2|CUGBP2|ETR-3|ETR3|NAPOR
Cytomap

19p13.3

10p14

Type of geneprotein-codingprotein-coding
Descriptionnicotinamide riboside kinase 2NRK 2RNK 2integrin beta-1-binding protein 3muscle-specific beta 1 integrin binding proteinnicotinic acid riboside kinase 2nmR-K 2ribosylnicotinamide kinase 2ribosylnicotinic acid kinase 2CUGBP Elav-like family member 2CUG triplet repeat RNA-binding protein 2CUG-BP- and ETR-3-like factor 2ELAV-type RNA-binding protein 3KDM2B/CELF2 fusionRNA-binding protein BRUNOL-3bruno-like protein 3neuroblastoma apoptosis-related RNA-binding prote
Modification date2020031320200313
UniProtAcc

Q9NPI5

Q8N7Q2

Ensembl transtripts involved in fusion geneENST00000168977, ENST00000593949, 
ENST00000599576, 		ENST00000315874, 
ENST00000354440, ENST00000354897, 
ENST00000379261, ENST00000399850, 
ENST00000416382, ENST00000417956, 
ENST00000427450, ENST00000450189, 
ENST00000537122, ENST00000542579, 
ENST00000608830, ENST00000609692, 
Fusion gene scores* DoF score1 X 1 X 1=114 X 15 X 3=630
# samples 115
** MAII scorelog2(1/1*10)=3.32192809488736log2(15/630*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NMRK2 [Title/Abstract] AND CELF2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNMRK2(3934573)-CELF2(10728260), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCELF2

GO:0006376

mRNA splice site selection

11158314


check buttonFusion gene breakpoints across NMRK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CELF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAF010941NMRK2chr19

3934573

+CELF2chr10

10728260

+


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Fusion Gene ORF analysis for NMRK2-CELF2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000168977ENST00000315874NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000168977ENST00000354440NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000168977ENST00000354897NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000168977ENST00000379261NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000168977ENST00000399850NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000168977ENST00000416382NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000168977ENST00000417956NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000168977ENST00000427450NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000168977ENST00000450189NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000168977ENST00000537122NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000168977ENST00000542579NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000168977ENST00000608830NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000168977ENST00000609692NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000593949ENST00000315874NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000593949ENST00000354440NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000593949ENST00000354897NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000593949ENST00000379261NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000593949ENST00000399850NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000593949ENST00000416382NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000593949ENST00000417956NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000593949ENST00000427450NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000593949ENST00000450189NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000593949ENST00000537122NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000593949ENST00000542579NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000593949ENST00000608830NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000593949ENST00000609692NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000599576ENST00000315874NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000599576ENST00000354440NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000599576ENST00000354897NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000599576ENST00000379261NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000599576ENST00000399850NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000599576ENST00000416382NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000599576ENST00000417956NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000599576ENST00000427450NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000599576ENST00000450189NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000599576ENST00000537122NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000599576ENST00000542579NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000599576ENST00000608830NMRK2chr19

3934573

+CELF2chr10

10728260

+
intron-intronENST00000599576ENST00000609692NMRK2chr19

3934573

+CELF2chr10

10728260

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NMRK2-CELF2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NMRK2-CELF2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:3934573/:10728260)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NMRK2

Q9NPI5

CELF2

Q8N7Q2

FUNCTION: Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis. {ECO:0000269|PubMed:10613898, ECO:0000269|PubMed:15137942}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NMRK2-CELF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NMRK2-CELF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NMRK2-CELF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NMRK2-CELF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource