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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NMT2-ITGA8 (FusionGDB2 ID:59476)

Fusion Gene Summary for NMT2-ITGA8

Fusion gene summary

Fusion gene information	Fusion gene name: NMT2-ITGA8
	Fusion gene ID: 59476
		Hgene	Tgene
	Gene symbol	NMT2	ITGA8
	Gene ID	9397	8516
	Gene name	N-myristoyltransferase 2	integrin subunit alpha 8
	Synonyms	-	-
	Cytomap	10p13	10p13
	Type of gene	protein-coding	protein-coding
	Description	glycylpeptide N-tetradecanoyltransferase 2NMT 2glycylpeptide N-tetradecanoyltransferase 2 variant 3glycylpeptide N-tetradecanoyltransferase 2 variant 4myristoyl-CoA:protein N-myristoyltransferase 2peptide N-myristoyltransferase 2type II N-myristoylt	integrin alpha-8integrin, alpha 8
	Modification date	20200313	20200313
	UniProtAcc	.	P53708
	Ensembl transtripts involved in fusion gene	ENST00000378150, ENST00000378165, ENST00000535341, ENST00000540259, ENST00000466201,	ENST00000477064, ENST00000378076,
Fusion gene scores	* DoF score	4 X 4 X 3=48	6 X 6 X 4=144
	# samples	4	6
	** MAII score	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NMT2 [Title/Abstract] AND ITGA8 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NMT2(15170349)-ITGA8(15639298), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NMT2	GO:0018008	N-terminal peptidyl-glycine N-myristoylation	25255805

Fusion gene breakpoints across NMT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ITGA8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AN-A0AM-01A	NMT2	chr10	15170349	-	ITGA8	chr10	15639298	-

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Fusion Gene ORF analysis for NMT2-ITGA8

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000378150	ENST00000477064	NMT2	chr10	15170349	-	ITGA8	chr10	15639298	-
5CDS-5UTR	ENST00000378165	ENST00000477064	NMT2	chr10	15170349	-	ITGA8	chr10	15639298	-
5CDS-5UTR	ENST00000535341	ENST00000477064	NMT2	chr10	15170349	-	ITGA8	chr10	15639298	-
5CDS-5UTR	ENST00000540259	ENST00000477064	NMT2	chr10	15170349	-	ITGA8	chr10	15639298	-
In-frame	ENST00000378150	ENST00000378076	NMT2	chr10	15170349	-	ITGA8	chr10	15639298	-
In-frame	ENST00000378165	ENST00000378076	NMT2	chr10	15170349	-	ITGA8	chr10	15639298	-
In-frame	ENST00000535341	ENST00000378076	NMT2	chr10	15170349	-	ITGA8	chr10	15639298	-
In-frame	ENST00000540259	ENST00000378076	NMT2	chr10	15170349	-	ITGA8	chr10	15639298	-
intron-3CDS	ENST00000466201	ENST00000378076	NMT2	chr10	15170349	-	ITGA8	chr10	15639298	-
intron-5UTR	ENST00000466201	ENST00000477064	NMT2	chr10	15170349	-	ITGA8	chr10	15639298	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000378165	NMT2	chr10	15170349	-	ENST00000378076	ITGA8	chr10	15639298	-	5363	1080	81	2153	690
ENST00000378150	NMT2	chr10	15170349	-	ENST00000378076	ITGA8	chr10	15639298	-	5341	1058	98	2131	677
ENST00000535341	NMT2	chr10	15170349	-	ENST00000378076	ITGA8	chr10	15639298	-	5302	1019	29	2092	687
ENST00000540259	NMT2	chr10	15170349	-	ENST00000378076	ITGA8	chr10	15639298	-	5443	1160	689	2233	514

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000378165	ENST00000378076	NMT2	chr10	15170349	-	ITGA8	chr10	15639298	-	0.000549798	0.99945015
ENST00000378150	ENST00000378076	NMT2	chr10	15170349	-	ITGA8	chr10	15639298	-	0.000482585	0.99951744
ENST00000535341	ENST00000378076	NMT2	chr10	15170349	-	ITGA8	chr10	15639298	-	0.000348197	0.9996518
ENST00000540259	ENST00000378076	NMT2	chr10	15170349	-	ITGA8	chr10	15639298	-	0.000517277	0.99948275

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Fusion Genomic Features for NMT2-ITGA8

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NMT2-ITGA8

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:15170349/chr10:15639298)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ITGA8 P53708
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. {ECO:0000269\|PubMed:12415008, ECO:0000269\|PubMed:15721307}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NMT2

chr10:15170349

chr10:15639298

ENST00000378165

46_56

333

499.0

Compositional bias

Note=Poly-Lys

Hgene

NMT2

chr10:15170349

chr10:15639298

ENST00000378165

120_122

333

499.0

Region

Myristoyl-CoA binding

Hgene

NMT2

chr10:15170349

chr10:15639298

ENST00000378165

250_252

333

499.0

Region

Myristoyl-CoA binding

Hgene

NMT2

chr10:15170349

chr10:15639298

ENST00000378165

258_262

333

499.0

Region

Myristoyl-CoA binding

Tgene

ITGA8

chr10:15170349

chr10:15639298

ENST00000378076

1034_1063

706

1064.0

Topological domain

Cytoplasmic

Tgene

ITGA8

chr10:15170349

chr10:15639298

ENST00000378076

1013_1033

706

1064.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ITGA8

chr10:15170349

chr10:15639298

ENST00000378076

329_337

706

1064.0

Calcium binding

Ontology_term=ECO:0000255

Tgene

ITGA8

chr10:15170349

chr10:15639298

ENST00000378076

395_403

706

1064.0

Calcium binding

Ontology_term=ECO:0000255

Tgene

ITGA8

chr10:15170349

chr10:15639298

ENST00000378076

459_467

706

1064.0

Calcium binding

Ontology_term=ECO:0000255

Tgene

ITGA8

chr10:15170349

chr10:15639298

ENST00000378076

455_457

706

1064.0

Motif

Cell attachment site

Tgene

ITGA8

chr10:15170349

chr10:15639298

ENST00000378076

122_183

706

1064.0

Repeat

FG-GAP 2

Tgene

ITGA8

chr10:15170349

chr10:15639298

ENST00000378076

188_240

706

1064.0

Repeat

FG-GAP 3

Tgene

ITGA8

chr10:15170349

chr10:15639298

ENST00000378076

253_306

706

1064.0

Repeat

FG-GAP 4

Tgene

ITGA8

chr10:15170349

chr10:15639298

ENST00000378076

307_372

706

1064.0

Repeat

FG-GAP 5

Tgene

ITGA8

chr10:15170349

chr10:15639298

ENST00000378076

373_431

706

1064.0

Repeat

FG-GAP 6

Tgene

ITGA8

chr10:15170349

chr10:15639298

ENST00000378076

435_498

706

1064.0

Repeat

FG-GAP 7

Tgene

ITGA8

chr10:15170349

chr10:15639298

ENST00000378076

44_105

706

1064.0

Repeat

FG-GAP 1

Tgene

ITGA8

chr10:15170349

chr10:15639298

ENST00000378076

39_1012

706

1064.0

Topological domain

Extracellular

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Fusion Gene Sequence for NMT2-ITGA8

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>59476_59476_1_NMT2-ITGA8_NMT2_chr10_15170349_ENST00000378150_ITGA8_chr10_15639298_ENST00000378076_length(transcript)=5341nt_BP=1058nt
AGCCAGCGCCGCCGCGATGGCGGAGGACAGCGAGTCTGCGGCCAGCCAGCAGAGCCTGGAACTGGACGACCAGGACACGTGCGGGATAGA
CGGGGACAATGAGGAGGAGACGGAGCACGCCAAAGGAAGTCCTGGAGGGTATTTGGGAGCCAAAAAGAAAAAGAAGAAACAGAAGAGAAA
AAAGGAGAAACCAAATTCCGGAGGCACCAAGTCAGACTCGGCATCTGATTCCCAGGAGATTAAAATTCAGCAGCCTTCGAAACACAACAC
CATCTGGCAGCAGATTTCAGCGGGAGCAGCCATGGAATCCCAGTGTTCCAATGCAGAAGTTGCAGGATATCCAGAGAGCAATGGAGCTGC
TATCCGCATGCCAGGGCCCAGCCAGGAACATTGATGAGGCTGCAAAGCACAGATACCAGTTTTGGGACACACAACCGGTACCAAAACTAG
ATGAAGTCATAACATCTCATGGTGCAATTGAACCAGATAAAGACAACGTACGCCAAGAACCGTATTCTTTGCCACAGGGTTTTATGTGGG
ACACTTTAGACTTGAGTGATGCCGAAGTGCTCAAGGAGTTATACACGTTGTTAAATGAGAATTACGTAGAAGATGATGACAATATGTTCC
GATTTGACTATTCACCCGAGTTCCTGTTGTGGGCTCTGCGTCCACCAGGCTGGCTCCTGCAGTGGCACTGTGGGGTCAGAGTGTCTTCAA
ATAAAAAACTGGTCGGGTTCATAAGTGCCATCCCAGCAAACATTCGGATTTATGACAGTGTGAAGAAGATGGTAGAAATCAACTTTCTTT
GTGTTCATAAGAAGTTGAGATCGAAACGGGTAGCCCCAGTGCTAATCCGAGAGATCACTAGAAGAGTGAACCTGGAAGGGATCTTCCAGG
CTGTGTACACCGCGGGAGTGGTTCTTCCTAAGCCCATAGCCACATGCAGATACTGGCATCGATCACTAAACCCCAGAAAATTGGTAGAAG
TGAAATTTTCTCACTTGAGTAGAAATATGACTTTACAGAGAACAATGAAGCTATACAGACTTCCAGATGGATTTCGACCACTGAGCTGTG
AGTACAAGATGGAAAATGTAACCAGGATGGTGGTGTGTGACCTTGGGAACCCTATGGTGTCTGGAACAAATTATTCCCTGGGCCTCCGAT
TTGCAGTTCCACGTCTTGAGAAAACAAACATGAGCATTAACTTCGATCTCCAAATCAGAAGTTCCAACAAGGACAATCCAGACAGCAATT
TTGTGAGCCTGCAAATCAACATCACTGCTGTAGCGCAGGTGGAAATAAGAGGAGTGTCACACCCTCCGCAGATTGTTCTGCCCATTCATA
ACTGGGAACCAGAAGAGGAGCCCCACAAAGAGGAGGAGGTTGGACCATTGGTGGAACATATTTATGAGCTGCACAATATTGGACCAAGTA
CCATCAGTGACACCATCCTGGAGGTGGGCTGGCCTTTCTCTGCCCGGGATGAATTTCTTCTCTATATTTTCCATATTCAAACTCTGGGAC
CTCTGCAGTGCCAACCAAATCCTAATATCAATCCACAGGATATAAAGCCTGCTGCCTCCCCAGAGGACACCCCTGAGCTCAGCGCCTTTT
TGCGAAACTCTACTATTCCTCATCTTGTCAGGAAGAGGGATGTACATGTGGTCGAATTCCACAGACAGAGCCCTGCAAAAATACTGAATT
GTACAAATATCGAGTGTTTACAAATCTCCTGTGCAGTGGGACGACTCGAAGGAGGAGAAAGCGCAGTCCTGAAAGTCAGGTCACGATTAT
GGGCCCACACCTTCCTCCAGAGAAAAAATGATCCCTATGCTCTTGCATCCCTGGTGTCCTTTGAAGTTAAGAAGATGCCTTATACAGATC
AGCCAGCAAAACTCCCAGAAGGAAGCATAGTAATTAAGACATCAGTTATTTGGGCAACTCCGAATGTTTCCTTCTCAATCCCATTATGGG
TAATAATACTAGCAATACTTCTTGGATTGTTGGTTCTCGCCATTTTAACCTTAGCTTTATGGAAGTGTGGATTCTTTGACAGAGCCAGAC
CTCCTCAGGAGGACATGACCGACAGGGAACAGCTGACAAATGACAAGACCCCTGAGGCATGACAAGAAAAAAAAAGAAGACCAAAGACCT
CAAACACTGGTCCTGTTCAAAGAAAAAGAAAGAACATGAGGGTTAAAAATCAAAGCTTTCTGATACCTGACAGTGACCCAGGAAATGGAG
GGGACCCTGGAAACATCACCTCATCTACACCGCACTTTGGAGAAATTGTCCTGGGTGCCCAGTGAGCCCTGTTGGAAAAGGAAACACCAA
AGCTGGAGAAGCCATCAGCAATTGTGGAAGATTTTCTTTTGCTTTAATCGTTCTGTACTTGGCAGACACTTTGAAATGCGTATGGGAACG
TAAGTTGCAGTCCAGATCAATCCAGCATAAGTTGCAGAGATGAAATGTCTGAATCACTATAGAATTTACAAGGTGAACTAAGGTGAAATG
ACTGATTTACTATAGAACTTAGAACTAAGACCACACCATCCAACACTACTGTATCCAATGGAACATTTGACACCTCCCTATGGAAAAGAA
ACATTTCTAAGGACATTATGGCTCAGGGAGACAAGCAATATGTTGTTGGTACTGTGAAAGTACTTTTGAAAGGACAAAAATAATCTTGTG
AGTGAGGGTGAGAGTTTATTTATTTATTTTCCATGTCTCTAGGTTGAGAATCTGTCATCTAGAGAATTTGGAAATTAAGATTTGGTTAGC
TAGTTTTCAAAATCACTCACTCAGTTTCCTCCTAAGAACCACTGTGTGCAGATAACTCATTTAGCAGAGCTTCTTCAGAATTTAGACAGT
GCTAAGGAAAGGAAGATTGGCATTAGGAATCAGTTCTATTTAATACCTTGCTGCCTTCCATCTGAAATTCCTTTCACTCACATTATCCAG
GGACTCACATCTGCTTAATTTAGCTTTGCAAGATGTTGCATTTATATTTCCTTGTATATCTTTCCATTGACTTAGTTAATACATGAATTT
CGAGGTACTCTCTACCTTTGGAGTGTTTAAAAGTCATGGTAAAATGTCTAGAGTTCATTAATTAAAAAGCAATTTAACATTATGGGTAAA
CATTATTTTTAATATCTATAAGAAGCAACACTTCTTATAGATATTTAGCTTGGGATTAAATACCCGTTTTTCCTGCTATGCCTTGTACTT
GTATACACAGAGAAAACATGTTGAATATAACTTAGACAAAAACATAAAATTATACAGGCATGAGCCAAACTGGGAAAACTGATTCCTAAA
GATTTTTATTTAAAATTGCTTATTCCAACTTTATTACTTATTTTTACTGCTAATCTTTATAATATGTAACTTTGGAGAATAATCTTTTAT
TTAAGCTATTTTCCCATCATCTTGAATTTAACCATCACAAATTTTTTATGTTTAAAACTCTTGTAAATAATTCATAATCTTGTAATATTA
TCATTTTTGAAGTAAAATTGACCAGCCAAATTTATAGGTAGTCTGCACAATTTTGTATCCTTTTTTAATAATGAAAAATTACTATGAAGA
AATACTGAACAAATTTTTATGTGCAATATTTTATAGACCTATGTATCTGAAGCATGTTTACACTGGCGTTTTTTTTTTTAATTAATTTCC
TAAATGTTAAGTATGATAGAACAAGCTGACCCAAATCCTTAAGTTTACAAAGCTGTTGGAAAACTTTGTGTCCTGATTTCAACAATCACG
CTTTGTTTGAAAGATGAGCCAAGCTCACAGACACTAAATTTTATGTCATGCCATAAGCTGGAGAGGAGCCATTTGGCTACAGCTGCGGAA
CTTCATTGAGGAGCAAATGAAAGGCACATGGACGAGCACGCTGGTGCAGTTCATGTTCTTCCTGCCTGTGAATTGAATACTGTCCTGGTA
GCAGTTTCGGGTCGGTCAGGAGCTCAAGGCTGGTTTGTGTGGCTGACTACGGATGAGCACTGAAGTTGCCTCAAAGAATTAAGGGGTGTC
CACACCAGCCTCTGGGGGTCTTTGGTGTTAGTCTTCCAGGTAGAGCTGGTTTTACAAGTAGGTGGCCATCTACAGGATGTGATGTGAGCG
ATGCCAGACAGCTCTCTCTGACCCCAGGTAATGCCCTGAATCTGGTGATCCTGGCTGATCTGTGACCAATAGAGATTAGCTCCTTGGGAT
TTGGGGTCCTAAAAGGTCCCTGAAAAAATGCACCCCTTGTCTTTAAGCCAACATTGGTGAAGGAACTGAGAACTCTTAGGGTTACATAAA
AAAAGACCCCTGTTGAGATAGTTTATGCAGATACCTGGAAGGAACTAGAGATGCCAGGAGGAAGACTGAGACCCAGAATGAAGCAAGGCA
TGAGGGCTCCAAAGTGAACTGCACCATCCCAGAGTCTCAGCCAAGATGGCCCTTTCCTAGAGGGACGGGCACCTTCCACCTGCCCACAGG
CACTGCTACCTATGGGAATTGCAGAAGGCCGTTGTACACACGCGCATGCACGCAGTGGCCCTCTGCCCTTTAGAATATGGAAGCAAAGTC
TGGGTGCAGTGACTCACACTTGTAATCCCAACACTTTGGGAGGCCGAGACGGGCAGATCACCTGAGTTCAGGAGTTCAAGACCAGCCTGG
CCAACGTGGCAAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGCAGTCTCCTGTAATCCCAGCTACCTAGGAGGCT
GAGGCAGAGAGAGAATCGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCTGAGATCGCGCGACTGCACTCCAGCCTGGGCGACAGAGGG
AAACTCTGTCTCAACAAAAAAATAAATAAAATAAAAAATAAAAAAAGAATATGGAAGCAAATGGAGAAAGGGAGGAAACTGAGGTCAGGC
AAACCTTCCAGCAATCCGTTCTGCCCAGAGAACATACTGACGACAGAGAACACACTGAGCGTTATCTGCTTCTAGTTAGAGCATTGCCGA
TTGCCTTCATAATTCATAATGTGCTGTGCTCCTCTGAGGGTCTATCTGTATTTCTCTTCAAAGAATTCCCTTTTTAAATTCTTGCAGCTG
GGTTTTAAGACACAATAATGGGGCAAATTAAGTTTTATAAACTTGGAGATTTTTATACAGTAAATAAAAAAATAATATGTACTAGTCACC
CCTGAAACTGCATTCTTAGAACTCGACTCTTGTTTTATTTAAATACGTGCGTAGATATCTGTGAAGATTTTCATGTACCTATTTACCTTG

>59476_59476_1_NMT2-ITGA8_NMT2_chr10_15170349_ENST00000378150_ITGA8_chr10_15639298_ENST00000378076_length(amino acids)=677AA_BP=320
MRRRRSTPKEVLEGIWEPKRKRRNRREKRRNQIPEAPSQTRHLIPRRLKFSSLRNTTPSGSRFQREQPWNPSVPMQKLQDIQRAMELLSA
CQGPARNIDEAAKHRYQFWDTQPVPKLDEVITSHGAIEPDKDNVRQEPYSLPQGFMWDTLDLSDAEVLKELYTLLNENYVEDDDNMFRFD
YSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKKMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVY
TAGVVLPKPIATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDGFRPLSCEYKMENVTRMVVCDLGNPMVSGTNYSLGLRFAV
PRLEKTNMSINFDLQIRSSNKDNPDSNFVSLQINITAVAQVEIRGVSHPPQIVLPIHNWEPEEEPHKEEEVGPLVEHIYELHNIGPSTIS
DTILEVGWPFSARDEFLLYIFHIQTLGPLQCQPNPNINPQDIKPAASPEDTPELSAFLRNSTIPHLVRKRDVHVVEFHRQSPAKILNCTN
IECLQISCAVGRLEGGESAVLKVRSRLWAHTFLQRKNDPYALASLVSFEVKKMPYTDQPAKLPEGSIVIKTSVIWATPNVSFSIPLWVII

--------------------------------------------------------------
>59476_59476_2_NMT2-ITGA8_NMT2_chr10_15170349_ENST00000378165_ITGA8_chr10_15639298_ENST00000378076_length(transcript)=5363nt_BP=1080nt
AGTACGGCGGGAGGCACTAGAGGGAGCTGCGGCCGCTCCGGCCCGGCCCCGAGCACCGCCTCCCCAGCCAGCGCCGCCGCGATGGCGGAG
GACAGCGAGTCTGCGGCCAGCCAGCAGAGCCTGGAACTGGACGACCAGGACACGTGCGGGATAGACGGGGACAATGAGGAGGAGACGGAG
CACGCCAAAGGAAGTCCTGGAGGGTATTTGGGAGCCAAAAAGAAAAAGAAGAAACAGAAGAGAAAAAAGGAGAAACCAAATTCCGGAGGC
ACCAAGTCAGACTCGGCATCTGATTCCCAGGAGATTAAAATTCAGCAGCCTTCGAAAAATCCCAGTGTTCCAATGCAGAAGTTGCAGGAT
ATCCAGAGAGCAATGGAGCTGCTATCCGCATGCCAGGGCCCAGCCAGGAACATTGATGAGGCTGCAAAGCACAGATACCAGTTTTGGGAC
ACACAACCGGTACCAAAACTAGATGAAGTCATAACATCTCATGGTGCAATTGAACCAGATAAAGACAACGTACGCCAAGAACCGTATTCT
TTGCCACAGGGTTTTATGTGGGACACTTTAGACTTGAGTGATGCCGAAGTGCTCAAGGAGTTATACACGTTGTTAAATGAGAATTACGTA
GAAGATGATGACAATATGTTCCGATTTGACTATTCACCCGAGTTCCTGTTGTGGGCTCTGCGTCCACCAGGCTGGCTCCTGCAGTGGCAC
TGTGGGGTCAGAGTGTCTTCAAATAAAAAACTGGTCGGGTTCATAAGTGCCATCCCAGCAAACATTCGGATTTATGACAGTGTGAAGAAG
ATGGTAGAAATCAACTTTCTTTGTGTTCATAAGAAGTTGAGATCGAAACGGGTAGCCCCAGTGCTAATCCGAGAGATCACTAGAAGAGTG
AACCTGGAAGGGATCTTCCAGGCTGTGTACACCGCGGGAGTGGTTCTTCCTAAGCCCATAGCCACATGCAGATACTGGCATCGATCACTA
AACCCCAGAAAATTGGTAGAAGTGAAATTTTCTCACTTGAGTAGAAATATGACTTTACAGAGAACAATGAAGCTATACAGACTTCCAGAT
GGATTTCGACCACTGAGCTGTGAGTACAAGATGGAAAATGTAACCAGGATGGTGGTGTGTGACCTTGGGAACCCTATGGTGTCTGGAACA
AATTATTCCCTGGGCCTCCGATTTGCAGTTCCACGTCTTGAGAAAACAAACATGAGCATTAACTTCGATCTCCAAATCAGAAGTTCCAAC
AAGGACAATCCAGACAGCAATTTTGTGAGCCTGCAAATCAACATCACTGCTGTAGCGCAGGTGGAAATAAGAGGAGTGTCACACCCTCCG
CAGATTGTTCTGCCCATTCATAACTGGGAACCAGAAGAGGAGCCCCACAAAGAGGAGGAGGTTGGACCATTGGTGGAACATATTTATGAG
CTGCACAATATTGGACCAAGTACCATCAGTGACACCATCCTGGAGGTGGGCTGGCCTTTCTCTGCCCGGGATGAATTTCTTCTCTATATT
TTCCATATTCAAACTCTGGGACCTCTGCAGTGCCAACCAAATCCTAATATCAATCCACAGGATATAAAGCCTGCTGCCTCCCCAGAGGAC
ACCCCTGAGCTCAGCGCCTTTTTGCGAAACTCTACTATTCCTCATCTTGTCAGGAAGAGGGATGTACATGTGGTCGAATTCCACAGACAG
AGCCCTGCAAAAATACTGAATTGTACAAATATCGAGTGTTTACAAATCTCCTGTGCAGTGGGACGACTCGAAGGAGGAGAAAGCGCAGTC
CTGAAAGTCAGGTCACGATTATGGGCCCACACCTTCCTCCAGAGAAAAAATGATCCCTATGCTCTTGCATCCCTGGTGTCCTTTGAAGTT
AAGAAGATGCCTTATACAGATCAGCCAGCAAAACTCCCAGAAGGAAGCATAGTAATTAAGACATCAGTTATTTGGGCAACTCCGAATGTT
TCCTTCTCAATCCCATTATGGGTAATAATACTAGCAATACTTCTTGGATTGTTGGTTCTCGCCATTTTAACCTTAGCTTTATGGAAGTGT
GGATTCTTTGACAGAGCCAGACCTCCTCAGGAGGACATGACCGACAGGGAACAGCTGACAAATGACAAGACCCCTGAGGCATGACAAGAA
AAAAAAAGAAGACCAAAGACCTCAAACACTGGTCCTGTTCAAAGAAAAAGAAAGAACATGAGGGTTAAAAATCAAAGCTTTCTGATACCT
GACAGTGACCCAGGAAATGGAGGGGACCCTGGAAACATCACCTCATCTACACCGCACTTTGGAGAAATTGTCCTGGGTGCCCAGTGAGCC
CTGTTGGAAAAGGAAACACCAAAGCTGGAGAAGCCATCAGCAATTGTGGAAGATTTTCTTTTGCTTTAATCGTTCTGTACTTGGCAGACA
CTTTGAAATGCGTATGGGAACGTAAGTTGCAGTCCAGATCAATCCAGCATAAGTTGCAGAGATGAAATGTCTGAATCACTATAGAATTTA
CAAGGTGAACTAAGGTGAAATGACTGATTTACTATAGAACTTAGAACTAAGACCACACCATCCAACACTACTGTATCCAATGGAACATTT
GACACCTCCCTATGGAAAAGAAACATTTCTAAGGACATTATGGCTCAGGGAGACAAGCAATATGTTGTTGGTACTGTGAAAGTACTTTTG
AAAGGACAAAAATAATCTTGTGAGTGAGGGTGAGAGTTTATTTATTTATTTTCCATGTCTCTAGGTTGAGAATCTGTCATCTAGAGAATT
TGGAAATTAAGATTTGGTTAGCTAGTTTTCAAAATCACTCACTCAGTTTCCTCCTAAGAACCACTGTGTGCAGATAACTCATTTAGCAGA
GCTTCTTCAGAATTTAGACAGTGCTAAGGAAAGGAAGATTGGCATTAGGAATCAGTTCTATTTAATACCTTGCTGCCTTCCATCTGAAAT
TCCTTTCACTCACATTATCCAGGGACTCACATCTGCTTAATTTAGCTTTGCAAGATGTTGCATTTATATTTCCTTGTATATCTTTCCATT
GACTTAGTTAATACATGAATTTCGAGGTACTCTCTACCTTTGGAGTGTTTAAAAGTCATGGTAAAATGTCTAGAGTTCATTAATTAAAAA
GCAATTTAACATTATGGGTAAACATTATTTTTAATATCTATAAGAAGCAACACTTCTTATAGATATTTAGCTTGGGATTAAATACCCGTT
TTTCCTGCTATGCCTTGTACTTGTATACACAGAGAAAACATGTTGAATATAACTTAGACAAAAACATAAAATTATACAGGCATGAGCCAA
ACTGGGAAAACTGATTCCTAAAGATTTTTATTTAAAATTGCTTATTCCAACTTTATTACTTATTTTTACTGCTAATCTTTATAATATGTA
ACTTTGGAGAATAATCTTTTATTTAAGCTATTTTCCCATCATCTTGAATTTAACCATCACAAATTTTTTATGTTTAAAACTCTTGTAAAT
AATTCATAATCTTGTAATATTATCATTTTTGAAGTAAAATTGACCAGCCAAATTTATAGGTAGTCTGCACAATTTTGTATCCTTTTTTAA
TAATGAAAAATTACTATGAAGAAATACTGAACAAATTTTTATGTGCAATATTTTATAGACCTATGTATCTGAAGCATGTTTACACTGGCG
TTTTTTTTTTTAATTAATTTCCTAAATGTTAAGTATGATAGAACAAGCTGACCCAAATCCTTAAGTTTACAAAGCTGTTGGAAAACTTTG
TGTCCTGATTTCAACAATCACGCTTTGTTTGAAAGATGAGCCAAGCTCACAGACACTAAATTTTATGTCATGCCATAAGCTGGAGAGGAG
CCATTTGGCTACAGCTGCGGAACTTCATTGAGGAGCAAATGAAAGGCACATGGACGAGCACGCTGGTGCAGTTCATGTTCTTCCTGCCTG
TGAATTGAATACTGTCCTGGTAGCAGTTTCGGGTCGGTCAGGAGCTCAAGGCTGGTTTGTGTGGCTGACTACGGATGAGCACTGAAGTTG
CCTCAAAGAATTAAGGGGTGTCCACACCAGCCTCTGGGGGTCTTTGGTGTTAGTCTTCCAGGTAGAGCTGGTTTTACAAGTAGGTGGCCA
TCTACAGGATGTGATGTGAGCGATGCCAGACAGCTCTCTCTGACCCCAGGTAATGCCCTGAATCTGGTGATCCTGGCTGATCTGTGACCA
ATAGAGATTAGCTCCTTGGGATTTGGGGTCCTAAAAGGTCCCTGAAAAAATGCACCCCTTGTCTTTAAGCCAACATTGGTGAAGGAACTG
AGAACTCTTAGGGTTACATAAAAAAAGACCCCTGTTGAGATAGTTTATGCAGATACCTGGAAGGAACTAGAGATGCCAGGAGGAAGACTG
AGACCCAGAATGAAGCAAGGCATGAGGGCTCCAAAGTGAACTGCACCATCCCAGAGTCTCAGCCAAGATGGCCCTTTCCTAGAGGGACGG
GCACCTTCCACCTGCCCACAGGCACTGCTACCTATGGGAATTGCAGAAGGCCGTTGTACACACGCGCATGCACGCAGTGGCCCTCTGCCC
TTTAGAATATGGAAGCAAAGTCTGGGTGCAGTGACTCACACTTGTAATCCCAACACTTTGGGAGGCCGAGACGGGCAGATCACCTGAGTT
CAGGAGTTCAAGACCAGCCTGGCCAACGTGGCAAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGCAGTCTCCTGT
AATCCCAGCTACCTAGGAGGCTGAGGCAGAGAGAGAATCGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCTGAGATCGCGCGACTGCA
CTCCAGCCTGGGCGACAGAGGGAAACTCTGTCTCAACAAAAAAATAAATAAAATAAAAAATAAAAAAAGAATATGGAAGCAAATGGAGAA
AGGGAGGAAACTGAGGTCAGGCAAACCTTCCAGCAATCCGTTCTGCCCAGAGAACATACTGACGACAGAGAACACACTGAGCGTTATCTG
CTTCTAGTTAGAGCATTGCCGATTGCCTTCATAATTCATAATGTGCTGTGCTCCTCTGAGGGTCTATCTGTATTTCTCTTCAAAGAATTC
CCTTTTTAAATTCTTGCAGCTGGGTTTTAAGACACAATAATGGGGCAAATTAAGTTTTATAAACTTGGAGATTTTTATACAGTAAATAAA
AAAATAATATGTACTAGTCACCCCTGAAACTGCATTCTTAGAACTCGACTCTTGTTTTATTTAAATACGTGCGTAGATATCTGTGAAGAT

>59476_59476_2_NMT2-ITGA8_NMT2_chr10_15170349_ENST00000378165_ITGA8_chr10_15639298_ENST00000378076_length(amino acids)=690AA_BP=333
MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGYLGAKKKKKKQKRKKEKPNSGGTKSDSASDSQEIKIQQPSKNPSVPMQK
LQDIQRAMELLSACQGPARNIDEAAKHRYQFWDTQPVPKLDEVITSHGAIEPDKDNVRQEPYSLPQGFMWDTLDLSDAEVLKELYTLLNE
NYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKKMVEINFLCVHKKLRSKRVAPVLIREIT
RRVNLEGIFQAVYTAGVVLPKPIATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDGFRPLSCEYKMENVTRMVVCDLGNPMV
SGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSLQINITAVAQVEIRGVSHPPQIVLPIHNWEPEEEPHKEEEVGPLVEH
IYELHNIGPSTISDTILEVGWPFSARDEFLLYIFHIQTLGPLQCQPNPNINPQDIKPAASPEDTPELSAFLRNSTIPHLVRKRDVHVVEF
HRQSPAKILNCTNIECLQISCAVGRLEGGESAVLKVRSRLWAHTFLQRKNDPYALASLVSFEVKKMPYTDQPAKLPEGSIVIKTSVIWAT

--------------------------------------------------------------
>59476_59476_3_NMT2-ITGA8_NMT2_chr10_15170349_ENST00000535341_ITGA8_chr10_15639298_ENST00000378076_length(transcript)=5302nt_BP=1019nt
GGTCTCCCGTTCGGGGGTGGCTCCCAGGACTGGGGGTTCTTCGGCCGCTCCGCCCCGCGATGGCTTCTCCGTGGCGCGGAGCCCATGAAG
TCCTGGAGGGTATTTGGGAGCCAAAAAGAAAAAGAAGAAACAGAAGAGAAAAAAGGAGAAACCAAATTCCGGAGGCACCAAGTCAGACTC
GGCATCTGATTCCCAGGAGATTAAAATTCAGCAGCCTTCGAAACACAACACCATCTGGCAGCAGATTTCAGCGGGAGCAGCCATGGAATC
CCAGTGTTCCAATGCAGAAGTTGCAGGATATCCAGAGAGCAATGGAGCTGCTATCCGCATGCCAGGGCCCAGCCAGGAACATTGATGAGG
CTGCAAAGCACAGATACCAGTTTTGGGACACACAACCGGTACCAAAACTAGATGAAGTCATAACATCTCATGGTGCAATTGAACCAGATA
AAGACAACGTACGCCAAGAACCGTATTCTTTGCCACAGGGTTTTATGTGGGACACTTTAGACTTGAGTGATGCCGAAGTGCTCAAGGAGT
TATACACGTTGTTAAATGAGAATTACGTAGAAGATGATGACAATATGTTCCGATTTGACTATTCACCCGAGTTCCTGTTGTGGGCTCTGC
GTCCACCAGGCTGGCTCCTGCAGTGGCACTGTGGGGTCAGAGTGTCTTCAAATAAAAAACTGGTCGGGTTCATAAGTGCCATCCCAGCAA
ACATTCGGATTTATGACAGTGTGAAGAAGATGGTAGAAATCAACTTTCTTTGTGTTCATAAGAAGTTGAGATCGAAACGGGTAGCCCCAG
TGCTAATCCGAGAGATCACTAGAAGAGTGAACCTGGAAGGGATCTTCCAGGCTGTGTACACCGCGGGAGTGGTTCTTCCTAAGCCCATAG
CCACATGCAGATACTGGCATCGATCACTAAACCCCAGAAAATTGGTAGAAGTGAAATTTTCTCACTTGAGTAGAAATATGACTTTACAGA
GAACAATGAAGCTATACAGACTTCCAGATGGATTTCGACCACTGAGCTGTGAGTACAAGATGGAAAATGTAACCAGGATGGTGGTGTGTG
ACCTTGGGAACCCTATGGTGTCTGGAACAAATTATTCCCTGGGCCTCCGATTTGCAGTTCCACGTCTTGAGAAAACAAACATGAGCATTA
ACTTCGATCTCCAAATCAGAAGTTCCAACAAGGACAATCCAGACAGCAATTTTGTGAGCCTGCAAATCAACATCACTGCTGTAGCGCAGG
TGGAAATAAGAGGAGTGTCACACCCTCCGCAGATTGTTCTGCCCATTCATAACTGGGAACCAGAAGAGGAGCCCCACAAAGAGGAGGAGG
TTGGACCATTGGTGGAACATATTTATGAGCTGCACAATATTGGACCAAGTACCATCAGTGACACCATCCTGGAGGTGGGCTGGCCTTTCT
CTGCCCGGGATGAATTTCTTCTCTATATTTTCCATATTCAAACTCTGGGACCTCTGCAGTGCCAACCAAATCCTAATATCAATCCACAGG
ATATAAAGCCTGCTGCCTCCCCAGAGGACACCCCTGAGCTCAGCGCCTTTTTGCGAAACTCTACTATTCCTCATCTTGTCAGGAAGAGGG
ATGTACATGTGGTCGAATTCCACAGACAGAGCCCTGCAAAAATACTGAATTGTACAAATATCGAGTGTTTACAAATCTCCTGTGCAGTGG
GACGACTCGAAGGAGGAGAAAGCGCAGTCCTGAAAGTCAGGTCACGATTATGGGCCCACACCTTCCTCCAGAGAAAAAATGATCCCTATG
CTCTTGCATCCCTGGTGTCCTTTGAAGTTAAGAAGATGCCTTATACAGATCAGCCAGCAAAACTCCCAGAAGGAAGCATAGTAATTAAGA
CATCAGTTATTTGGGCAACTCCGAATGTTTCCTTCTCAATCCCATTATGGGTAATAATACTAGCAATACTTCTTGGATTGTTGGTTCTCG
CCATTTTAACCTTAGCTTTATGGAAGTGTGGATTCTTTGACAGAGCCAGACCTCCTCAGGAGGACATGACCGACAGGGAACAGCTGACAA
ATGACAAGACCCCTGAGGCATGACAAGAAAAAAAAAGAAGACCAAAGACCTCAAACACTGGTCCTGTTCAAAGAAAAAGAAAGAACATGA
GGGTTAAAAATCAAAGCTTTCTGATACCTGACAGTGACCCAGGAAATGGAGGGGACCCTGGAAACATCACCTCATCTACACCGCACTTTG
GAGAAATTGTCCTGGGTGCCCAGTGAGCCCTGTTGGAAAAGGAAACACCAAAGCTGGAGAAGCCATCAGCAATTGTGGAAGATTTTCTTT
TGCTTTAATCGTTCTGTACTTGGCAGACACTTTGAAATGCGTATGGGAACGTAAGTTGCAGTCCAGATCAATCCAGCATAAGTTGCAGAG
ATGAAATGTCTGAATCACTATAGAATTTACAAGGTGAACTAAGGTGAAATGACTGATTTACTATAGAACTTAGAACTAAGACCACACCAT
CCAACACTACTGTATCCAATGGAACATTTGACACCTCCCTATGGAAAAGAAACATTTCTAAGGACATTATGGCTCAGGGAGACAAGCAAT
ATGTTGTTGGTACTGTGAAAGTACTTTTGAAAGGACAAAAATAATCTTGTGAGTGAGGGTGAGAGTTTATTTATTTATTTTCCATGTCTC
TAGGTTGAGAATCTGTCATCTAGAGAATTTGGAAATTAAGATTTGGTTAGCTAGTTTTCAAAATCACTCACTCAGTTTCCTCCTAAGAAC
CACTGTGTGCAGATAACTCATTTAGCAGAGCTTCTTCAGAATTTAGACAGTGCTAAGGAAAGGAAGATTGGCATTAGGAATCAGTTCTAT
TTAATACCTTGCTGCCTTCCATCTGAAATTCCTTTCACTCACATTATCCAGGGACTCACATCTGCTTAATTTAGCTTTGCAAGATGTTGC
ATTTATATTTCCTTGTATATCTTTCCATTGACTTAGTTAATACATGAATTTCGAGGTACTCTCTACCTTTGGAGTGTTTAAAAGTCATGG
TAAAATGTCTAGAGTTCATTAATTAAAAAGCAATTTAACATTATGGGTAAACATTATTTTTAATATCTATAAGAAGCAACACTTCTTATA
GATATTTAGCTTGGGATTAAATACCCGTTTTTCCTGCTATGCCTTGTACTTGTATACACAGAGAAAACATGTTGAATATAACTTAGACAA
AAACATAAAATTATACAGGCATGAGCCAAACTGGGAAAACTGATTCCTAAAGATTTTTATTTAAAATTGCTTATTCCAACTTTATTACTT
ATTTTTACTGCTAATCTTTATAATATGTAACTTTGGAGAATAATCTTTTATTTAAGCTATTTTCCCATCATCTTGAATTTAACCATCACA
AATTTTTTATGTTTAAAACTCTTGTAAATAATTCATAATCTTGTAATATTATCATTTTTGAAGTAAAATTGACCAGCCAAATTTATAGGT
AGTCTGCACAATTTTGTATCCTTTTTTAATAATGAAAAATTACTATGAAGAAATACTGAACAAATTTTTATGTGCAATATTTTATAGACC
TATGTATCTGAAGCATGTTTACACTGGCGTTTTTTTTTTTAATTAATTTCCTAAATGTTAAGTATGATAGAACAAGCTGACCCAAATCCT
TAAGTTTACAAAGCTGTTGGAAAACTTTGTGTCCTGATTTCAACAATCACGCTTTGTTTGAAAGATGAGCCAAGCTCACAGACACTAAAT
TTTATGTCATGCCATAAGCTGGAGAGGAGCCATTTGGCTACAGCTGCGGAACTTCATTGAGGAGCAAATGAAAGGCACATGGACGAGCAC
GCTGGTGCAGTTCATGTTCTTCCTGCCTGTGAATTGAATACTGTCCTGGTAGCAGTTTCGGGTCGGTCAGGAGCTCAAGGCTGGTTTGTG
TGGCTGACTACGGATGAGCACTGAAGTTGCCTCAAAGAATTAAGGGGTGTCCACACCAGCCTCTGGGGGTCTTTGGTGTTAGTCTTCCAG
GTAGAGCTGGTTTTACAAGTAGGTGGCCATCTACAGGATGTGATGTGAGCGATGCCAGACAGCTCTCTCTGACCCCAGGTAATGCCCTGA
ATCTGGTGATCCTGGCTGATCTGTGACCAATAGAGATTAGCTCCTTGGGATTTGGGGTCCTAAAAGGTCCCTGAAAAAATGCACCCCTTG
TCTTTAAGCCAACATTGGTGAAGGAACTGAGAACTCTTAGGGTTACATAAAAAAAGACCCCTGTTGAGATAGTTTATGCAGATACCTGGA
AGGAACTAGAGATGCCAGGAGGAAGACTGAGACCCAGAATGAAGCAAGGCATGAGGGCTCCAAAGTGAACTGCACCATCCCAGAGTCTCA
GCCAAGATGGCCCTTTCCTAGAGGGACGGGCACCTTCCACCTGCCCACAGGCACTGCTACCTATGGGAATTGCAGAAGGCCGTTGTACAC
ACGCGCATGCACGCAGTGGCCCTCTGCCCTTTAGAATATGGAAGCAAAGTCTGGGTGCAGTGACTCACACTTGTAATCCCAACACTTTGG
GAGGCCGAGACGGGCAGATCACCTGAGTTCAGGAGTTCAAGACCAGCCTGGCCAACGTGGCAAAACCCCATCTCTACTAAAAATACAAAA
ATTAGCTGGGCGTGGTGGCAGTCTCCTGTAATCCCAGCTACCTAGGAGGCTGAGGCAGAGAGAGAATCGCTTGAACCCAGGAGGCGGAGG
TTGCAGTGAGCTGAGATCGCGCGACTGCACTCCAGCCTGGGCGACAGAGGGAAACTCTGTCTCAACAAAAAAATAAATAAAATAAAAAAT
AAAAAAAGAATATGGAAGCAAATGGAGAAAGGGAGGAAACTGAGGTCAGGCAAACCTTCCAGCAATCCGTTCTGCCCAGAGAACATACTG
ACGACAGAGAACACACTGAGCGTTATCTGCTTCTAGTTAGAGCATTGCCGATTGCCTTCATAATTCATAATGTGCTGTGCTCCTCTGAGG
GTCTATCTGTATTTCTCTTCAAAGAATTCCCTTTTTAAATTCTTGCAGCTGGGTTTTAAGACACAATAATGGGGCAAATTAAGTTTTATA
AACTTGGAGATTTTTATACAGTAAATAAAAAAATAATATGTACTAGTCACCCCTGAAACTGCATTCTTAGAACTCGACTCTTGTTTTATT

>59476_59476_3_NMT2-ITGA8_NMT2_chr10_15170349_ENST00000535341_ITGA8_chr10_15639298_ENST00000378076_length(amino acids)=687AA_BP=330
MGVLRPLRPAMASPWRGAHEVLEGIWEPKRKRRNRREKRRNQIPEAPSQTRHLIPRRLKFSSLRNTTPSGSRFQREQPWNPSVPMQKLQD
IQRAMELLSACQGPARNIDEAAKHRYQFWDTQPVPKLDEVITSHGAIEPDKDNVRQEPYSLPQGFMWDTLDLSDAEVLKELYTLLNENYV
EDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKKMVEINFLCVHKKLRSKRVAPVLIREITRRV
NLEGIFQAVYTAGVVLPKPIATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDGFRPLSCEYKMENVTRMVVCDLGNPMVSGT
NYSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSLQINITAVAQVEIRGVSHPPQIVLPIHNWEPEEEPHKEEEVGPLVEHIYE
LHNIGPSTISDTILEVGWPFSARDEFLLYIFHIQTLGPLQCQPNPNINPQDIKPAASPEDTPELSAFLRNSTIPHLVRKRDVHVVEFHRQ
SPAKILNCTNIECLQISCAVGRLEGGESAVLKVRSRLWAHTFLQRKNDPYALASLVSFEVKKMPYTDQPAKLPEGSIVIKTSVIWATPNV

--------------------------------------------------------------
>59476_59476_4_NMT2-ITGA8_NMT2_chr10_15170349_ENST00000540259_ITGA8_chr10_15639298_ENST00000378076_length(transcript)=5443nt_BP=1160nt
GAATTTGTTACTGCTCACGCCTTTCTGTGGGTCATGGCTTCCTCTGCTTCTGAGAGTGTCTCCTGATCTTTCTTCTCCTCTTCTCTAAGT
TCAAGTTGCTCTCACCTCATCTCCCCAGCCCTCTGCTCGGGAAGACCCTCATTCTCCTGCCCCAAGCTGTGGCTCCTAGAGAAGTCCTGG
AGGGTATTTGGGAGCCAAAAAGAAAAAGAAGAAACAGAAGAGAAAAAAGGAGAAACCAAATTCCGGAGGCACCAAGTCAGACTCGGCATC
TGATTCCCAGGAGATTAAAATTCAGCAGCCTTCGAAAAATCCCAGTGTTCCAATGCAGAAGTTGCAGGATATCCAGAGAGCAATGGAGCT
GCTATCCGCATGCCAGGGCCCAGCCAGGAACATTGATGAGGCTGCAAAGCACAGATACCAGTTTTGGGACACACAACCGGTACCAAAACT
AGATGAAGTCATAACATCTCATGGTGCAATTGAACCAGATAAAGACAACGTACGCCAAGAACCGTATTCTTTGCCACAGGGTTTTATGTG
GGACACTTTAGACTTGAGTGATGCCGAAGTGGTGAGTGAGTAAAAACCTCTTAAATTCAACTCCTGCATTCACACATTGCTTCTAAGTTG
ATTCTGAGCACCATGGATAGGACACTTGTTTTATCTTATAGCTCAAGGAGTTATACACGTTGTTAAATGAGAATTACGTAGAAGATGATG
ACAATATGTTCCGATTTGACTATTCACCCGAGTTCCTGTTGTGGGCTCTGCGTCCACCAGGCTGGCTCCTGCAGTGGCACTGTGGGGTCA
GAGTGTCTTCAAATAAAAAACTGGTCGGGTTCATAAGTGCCATCCCAGCAAACATTCGGATTTATGACAGTGTGAAGAAGATGGTAGAAA
TCAACTTTCTTTGTGTTCATAAGAAGTTGAGATCGAAACGGGTAGCCCCAGTGCTAATCCGAGAGATCACTAGAAGAGTGAACCTGGAAG
GGATCTTCCAGGCTGTGTACACCGCGGGAGTGGTTCTTCCTAAGCCCATAGCCACATGCAGATACTGGCATCGATCACTAAACCCCAGAA
AATTGGTAGAAGTGAAATTTTCTCACTTGAGTAGAAATATGACTTTACAGAGAACAATGAAGCTATACAGACTTCCAGATGGATTTCGAC
CACTGAGCTGTGAGTACAAGATGGAAAATGTAACCAGGATGGTGGTGTGTGACCTTGGGAACCCTATGGTGTCTGGAACAAATTATTCCC
TGGGCCTCCGATTTGCAGTTCCACGTCTTGAGAAAACAAACATGAGCATTAACTTCGATCTCCAAATCAGAAGTTCCAACAAGGACAATC
CAGACAGCAATTTTGTGAGCCTGCAAATCAACATCACTGCTGTAGCGCAGGTGGAAATAAGAGGAGTGTCACACCCTCCGCAGATTGTTC
TGCCCATTCATAACTGGGAACCAGAAGAGGAGCCCCACAAAGAGGAGGAGGTTGGACCATTGGTGGAACATATTTATGAGCTGCACAATA
TTGGACCAAGTACCATCAGTGACACCATCCTGGAGGTGGGCTGGCCTTTCTCTGCCCGGGATGAATTTCTTCTCTATATTTTCCATATTC
AAACTCTGGGACCTCTGCAGTGCCAACCAAATCCTAATATCAATCCACAGGATATAAAGCCTGCTGCCTCCCCAGAGGACACCCCTGAGC
TCAGCGCCTTTTTGCGAAACTCTACTATTCCTCATCTTGTCAGGAAGAGGGATGTACATGTGGTCGAATTCCACAGACAGAGCCCTGCAA
AAATACTGAATTGTACAAATATCGAGTGTTTACAAATCTCCTGTGCAGTGGGACGACTCGAAGGAGGAGAAAGCGCAGTCCTGAAAGTCA
GGTCACGATTATGGGCCCACACCTTCCTCCAGAGAAAAAATGATCCCTATGCTCTTGCATCCCTGGTGTCCTTTGAAGTTAAGAAGATGC
CTTATACAGATCAGCCAGCAAAACTCCCAGAAGGAAGCATAGTAATTAAGACATCAGTTATTTGGGCAACTCCGAATGTTTCCTTCTCAA
TCCCATTATGGGTAATAATACTAGCAATACTTCTTGGATTGTTGGTTCTCGCCATTTTAACCTTAGCTTTATGGAAGTGTGGATTCTTTG
ACAGAGCCAGACCTCCTCAGGAGGACATGACCGACAGGGAACAGCTGACAAATGACAAGACCCCTGAGGCATGACAAGAAAAAAAAAGAA
GACCAAAGACCTCAAACACTGGTCCTGTTCAAAGAAAAAGAAAGAACATGAGGGTTAAAAATCAAAGCTTTCTGATACCTGACAGTGACC
CAGGAAATGGAGGGGACCCTGGAAACATCACCTCATCTACACCGCACTTTGGAGAAATTGTCCTGGGTGCCCAGTGAGCCCTGTTGGAAA
AGGAAACACCAAAGCTGGAGAAGCCATCAGCAATTGTGGAAGATTTTCTTTTGCTTTAATCGTTCTGTACTTGGCAGACACTTTGAAATG
CGTATGGGAACGTAAGTTGCAGTCCAGATCAATCCAGCATAAGTTGCAGAGATGAAATGTCTGAATCACTATAGAATTTACAAGGTGAAC
TAAGGTGAAATGACTGATTTACTATAGAACTTAGAACTAAGACCACACCATCCAACACTACTGTATCCAATGGAACATTTGACACCTCCC
TATGGAAAAGAAACATTTCTAAGGACATTATGGCTCAGGGAGACAAGCAATATGTTGTTGGTACTGTGAAAGTACTTTTGAAAGGACAAA
AATAATCTTGTGAGTGAGGGTGAGAGTTTATTTATTTATTTTCCATGTCTCTAGGTTGAGAATCTGTCATCTAGAGAATTTGGAAATTAA
GATTTGGTTAGCTAGTTTTCAAAATCACTCACTCAGTTTCCTCCTAAGAACCACTGTGTGCAGATAACTCATTTAGCAGAGCTTCTTCAG
AATTTAGACAGTGCTAAGGAAAGGAAGATTGGCATTAGGAATCAGTTCTATTTAATACCTTGCTGCCTTCCATCTGAAATTCCTTTCACT
CACATTATCCAGGGACTCACATCTGCTTAATTTAGCTTTGCAAGATGTTGCATTTATATTTCCTTGTATATCTTTCCATTGACTTAGTTA
ATACATGAATTTCGAGGTACTCTCTACCTTTGGAGTGTTTAAAAGTCATGGTAAAATGTCTAGAGTTCATTAATTAAAAAGCAATTTAAC
ATTATGGGTAAACATTATTTTTAATATCTATAAGAAGCAACACTTCTTATAGATATTTAGCTTGGGATTAAATACCCGTTTTTCCTGCTA
TGCCTTGTACTTGTATACACAGAGAAAACATGTTGAATATAACTTAGACAAAAACATAAAATTATACAGGCATGAGCCAAACTGGGAAAA
CTGATTCCTAAAGATTTTTATTTAAAATTGCTTATTCCAACTTTATTACTTATTTTTACTGCTAATCTTTATAATATGTAACTTTGGAGA
ATAATCTTTTATTTAAGCTATTTTCCCATCATCTTGAATTTAACCATCACAAATTTTTTATGTTTAAAACTCTTGTAAATAATTCATAAT
CTTGTAATATTATCATTTTTGAAGTAAAATTGACCAGCCAAATTTATAGGTAGTCTGCACAATTTTGTATCCTTTTTTAATAATGAAAAA
TTACTATGAAGAAATACTGAACAAATTTTTATGTGCAATATTTTATAGACCTATGTATCTGAAGCATGTTTACACTGGCGTTTTTTTTTT
TAATTAATTTCCTAAATGTTAAGTATGATAGAACAAGCTGACCCAAATCCTTAAGTTTACAAAGCTGTTGGAAAACTTTGTGTCCTGATT
TCAACAATCACGCTTTGTTTGAAAGATGAGCCAAGCTCACAGACACTAAATTTTATGTCATGCCATAAGCTGGAGAGGAGCCATTTGGCT
ACAGCTGCGGAACTTCATTGAGGAGCAAATGAAAGGCACATGGACGAGCACGCTGGTGCAGTTCATGTTCTTCCTGCCTGTGAATTGAAT
ACTGTCCTGGTAGCAGTTTCGGGTCGGTCAGGAGCTCAAGGCTGGTTTGTGTGGCTGACTACGGATGAGCACTGAAGTTGCCTCAAAGAA
TTAAGGGGTGTCCACACCAGCCTCTGGGGGTCTTTGGTGTTAGTCTTCCAGGTAGAGCTGGTTTTACAAGTAGGTGGCCATCTACAGGAT
GTGATGTGAGCGATGCCAGACAGCTCTCTCTGACCCCAGGTAATGCCCTGAATCTGGTGATCCTGGCTGATCTGTGACCAATAGAGATTA
GCTCCTTGGGATTTGGGGTCCTAAAAGGTCCCTGAAAAAATGCACCCCTTGTCTTTAAGCCAACATTGGTGAAGGAACTGAGAACTCTTA
GGGTTACATAAAAAAAGACCCCTGTTGAGATAGTTTATGCAGATACCTGGAAGGAACTAGAGATGCCAGGAGGAAGACTGAGACCCAGAA
TGAAGCAAGGCATGAGGGCTCCAAAGTGAACTGCACCATCCCAGAGTCTCAGCCAAGATGGCCCTTTCCTAGAGGGACGGGCACCTTCCA
CCTGCCCACAGGCACTGCTACCTATGGGAATTGCAGAAGGCCGTTGTACACACGCGCATGCACGCAGTGGCCCTCTGCCCTTTAGAATAT
GGAAGCAAAGTCTGGGTGCAGTGACTCACACTTGTAATCCCAACACTTTGGGAGGCCGAGACGGGCAGATCACCTGAGTTCAGGAGTTCA
AGACCAGCCTGGCCAACGTGGCAAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGCAGTCTCCTGTAATCCCAGCT
ACCTAGGAGGCTGAGGCAGAGAGAGAATCGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCTGAGATCGCGCGACTGCACTCCAGCCTG
GGCGACAGAGGGAAACTCTGTCTCAACAAAAAAATAAATAAAATAAAAAATAAAAAAAGAATATGGAAGCAAATGGAGAAAGGGAGGAAA
CTGAGGTCAGGCAAACCTTCCAGCAATCCGTTCTGCCCAGAGAACATACTGACGACAGAGAACACACTGAGCGTTATCTGCTTCTAGTTA
GAGCATTGCCGATTGCCTTCATAATTCATAATGTGCTGTGCTCCTCTGAGGGTCTATCTGTATTTCTCTTCAAAGAATTCCCTTTTTAAA
TTCTTGCAGCTGGGTTTTAAGACACAATAATGGGGCAAATTAAGTTTTATAAACTTGGAGATTTTTATACAGTAAATAAAAAAATAATAT
GTACTAGTCACCCCTGAAACTGCATTCTTAGAACTCGACTCTTGTTTTATTTAAATACGTGCGTAGATATCTGTGAAGATTTTCATGTAC

>59476_59476_4_NMT2-ITGA8_NMT2_chr10_15170349_ENST00000540259_ITGA8_chr10_15639298_ENST00000378076_length(amino acids)=514AA_BP=157
MLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKKMVEINFLCVHKKLRSKRVAPVLI
REITRRVNLEGIFQAVYTAGVVLPKPIATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDGFRPLSCEYKMENVTRMVVCDLG
NPMVSGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSLQINITAVAQVEIRGVSHPPQIVLPIHNWEPEEEPHKEEEVGP
LVEHIYELHNIGPSTISDTILEVGWPFSARDEFLLYIFHIQTLGPLQCQPNPNINPQDIKPAASPEDTPELSAFLRNSTIPHLVRKRDVH
VVEFHRQSPAKILNCTNIECLQISCAVGRLEGGESAVLKVRSRLWAHTFLQRKNDPYALASLVSFEVKKMPYTDQPAKLPEGSIVIKTSV

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Fusion Gene PPI Analysis for NMT2-ITGA8

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for NMT2-ITGA8

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for NMT2-ITGA8

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source