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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NOL10-LAP3 (FusionGDB2 ID:59521)

Fusion Gene Summary for NOL10-LAP3

check button Fusion gene summary
Fusion gene informationFusion gene name: NOL10-LAP3
Fusion gene ID: 59521
HgeneTgene
Gene symbol

NOL10

LAP3

Gene ID

79954

51056

Gene namenucleolar protein 10leucine aminopeptidase 3
SynonymsPQBP5HEL-S-106|LAP|LAPEP|PEPS
Cytomap

2p25.1

4p15.32

Type of geneprotein-codingprotein-coding
Descriptionnucleolar protein 10H_NH0074G24.1polyglutamine binding protein 5cytosol aminopeptidaseLAP-3epididymis secretory protein Li 106leucyl aminopeptidasepeptidase Sproline aminopeptidaseprolyl aminopeptidase
Modification date2020031320200313
UniProtAcc.

P28838

Ensembl transtripts involved in fusion geneENST00000345985, ENST00000381685, 
ENST00000538384, ENST00000542668, 
ENST00000503467, ENST00000226299, 
ENST00000606142, 
Fusion gene scores* DoF score7 X 7 X 4=1968 X 7 X 7=392
# samples 88
** MAII scorelog2(8/196*10)=-1.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/392*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NOL10 [Title/Abstract] AND LAP3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNOL10(10784445)-LAP3(17583910), # samples:1
Anticipated loss of major functional domain due to fusion event.NOL10-LAP3 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NOL10-LAP3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NOL10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LAP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-A4YXNOL10chr2

10784445

-LAP3chr4

17583910

+


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Fusion Gene ORF analysis for NOL10-LAP3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000345985ENST00000503467NOL10chr2

10784445

-LAP3chr4

17583910

+
5CDS-intronENST00000381685ENST00000503467NOL10chr2

10784445

-LAP3chr4

17583910

+
5CDS-intronENST00000538384ENST00000503467NOL10chr2

10784445

-LAP3chr4

17583910

+
5CDS-intronENST00000542668ENST00000503467NOL10chr2

10784445

-LAP3chr4

17583910

+
Frame-shiftENST00000542668ENST00000226299NOL10chr2

10784445

-LAP3chr4

17583910

+
Frame-shiftENST00000542668ENST00000606142NOL10chr2

10784445

-LAP3chr4

17583910

+
In-frameENST00000345985ENST00000226299NOL10chr2

10784445

-LAP3chr4

17583910

+
In-frameENST00000345985ENST00000606142NOL10chr2

10784445

-LAP3chr4

17583910

+
In-frameENST00000381685ENST00000226299NOL10chr2

10784445

-LAP3chr4

17583910

+
In-frameENST00000381685ENST00000606142NOL10chr2

10784445

-LAP3chr4

17583910

+
In-frameENST00000538384ENST00000226299NOL10chr2

10784445

-LAP3chr4

17583910

+
In-frameENST00000538384ENST00000606142NOL10chr2

10784445

-LAP3chr4

17583910

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000345985NOL10chr210784445-ENST00000226299LAP3chr417583910+2653987992273724
ENST00000345985NOL10chr210784445-ENST00000606142LAP3chr417583910+2619987992273724
ENST00000381685NOL10chr210784445-ENST00000226299LAP3chr417583910+27981132942418774
ENST00000381685NOL10chr210784445-ENST00000606142LAP3chr417583910+27641132942418774
ENST00000538384NOL10chr210784445-ENST00000226299LAP3chr417583910+272810621022348748
ENST00000538384NOL10chr210784445-ENST00000606142LAP3chr417583910+269410621022348748

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000345985ENST00000226299NOL10chr210784445-LAP3chr417583910+0.0008922560.9991078
ENST00000345985ENST00000606142NOL10chr210784445-LAP3chr417583910+0.0008806070.99911934
ENST00000381685ENST00000226299NOL10chr210784445-LAP3chr417583910+0.0007066440.9992933
ENST00000381685ENST00000606142NOL10chr210784445-LAP3chr417583910+0.0007017060.99929833
ENST00000538384ENST00000226299NOL10chr210784445-LAP3chr417583910+0.000964520.9990355
ENST00000538384ENST00000606142NOL10chr210784445-LAP3chr417583910+0.0009673610.9990326

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Fusion Genomic Features for NOL10-LAP3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NOL10chr210784445-LAP3chr417583910+0.0002360070.999764
NOL10chr210784445-LAP3chr417583910+0.0002360070.999764

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NOL10-LAP3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:10784445/chr4:17583910)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LAP3

P28838

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Cytolosic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status. {ECO:0000250|UniProtKB:P00727}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNOL10chr2:10784445chr4:17583910ENST00000345985-1220127_163292639.0RepeatNote=WD 3
HgeneNOL10chr2:10784445chr4:17583910ENST00000345985-1220170_205292639.0RepeatNote=WD 4
HgeneNOL10chr2:10784445chr4:17583910ENST00000345985-1220219_258292639.0RepeatNote=WD 5
HgeneNOL10chr2:10784445chr4:17583910ENST00000345985-122044_82292639.0RepeatNote=WD 1
HgeneNOL10chr2:10784445chr4:17583910ENST00000345985-122088_124292639.0RepeatNote=WD 2
HgeneNOL10chr2:10784445chr4:17583910ENST00000381685-1321127_163342689.0RepeatNote=WD 3
HgeneNOL10chr2:10784445chr4:17583910ENST00000381685-1321170_205342689.0RepeatNote=WD 4
HgeneNOL10chr2:10784445chr4:17583910ENST00000381685-1321219_258342689.0RepeatNote=WD 5
HgeneNOL10chr2:10784445chr4:17583910ENST00000381685-1321262_300342689.0RepeatNote=WD 6
HgeneNOL10chr2:10784445chr4:17583910ENST00000381685-1321304_341342689.0RepeatNote=WD 7
HgeneNOL10chr2:10784445chr4:17583910ENST00000381685-132144_82342689.0RepeatNote=WD 1
HgeneNOL10chr2:10784445chr4:17583910ENST00000381685-132188_124342689.0RepeatNote=WD 2
HgeneNOL10chr2:10784445chr4:17583910ENST00000538384-1220127_163316663.0RepeatNote=WD 3
HgeneNOL10chr2:10784445chr4:17583910ENST00000538384-1220170_205316663.0RepeatNote=WD 4
HgeneNOL10chr2:10784445chr4:17583910ENST00000538384-1220219_258316663.0RepeatNote=WD 5
HgeneNOL10chr2:10784445chr4:17583910ENST00000538384-1220262_300316663.0RepeatNote=WD 6
HgeneNOL10chr2:10784445chr4:17583910ENST00000538384-122044_82316663.0RepeatNote=WD 1
HgeneNOL10chr2:10784445chr4:17583910ENST00000538384-122088_124316663.0RepeatNote=WD 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNOL10chr2:10784445chr4:17583910ENST00000345985-1220423_446292639.0Coiled coilOntology_term=ECO:0000255
HgeneNOL10chr2:10784445chr4:17583910ENST00000345985-1220514_589292639.0Coiled coilOntology_term=ECO:0000255
HgeneNOL10chr2:10784445chr4:17583910ENST00000345985-1220640_673292639.0Coiled coilOntology_term=ECO:0000255
HgeneNOL10chr2:10784445chr4:17583910ENST00000381685-1321423_446342689.0Coiled coilOntology_term=ECO:0000255
HgeneNOL10chr2:10784445chr4:17583910ENST00000381685-1321514_589342689.0Coiled coilOntology_term=ECO:0000255
HgeneNOL10chr2:10784445chr4:17583910ENST00000381685-1321640_673342689.0Coiled coilOntology_term=ECO:0000255
HgeneNOL10chr2:10784445chr4:17583910ENST00000538384-1220423_446316663.0Coiled coilOntology_term=ECO:0000255
HgeneNOL10chr2:10784445chr4:17583910ENST00000538384-1220514_589316663.0Coiled coilOntology_term=ECO:0000255
HgeneNOL10chr2:10784445chr4:17583910ENST00000538384-1220640_673316663.0Coiled coilOntology_term=ECO:0000255
HgeneNOL10chr2:10784445chr4:17583910ENST00000345985-1220262_300292639.0RepeatNote=WD 6
HgeneNOL10chr2:10784445chr4:17583910ENST00000345985-1220304_341292639.0RepeatNote=WD 7
HgeneNOL10chr2:10784445chr4:17583910ENST00000538384-1220304_341316663.0RepeatNote=WD 7


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Fusion Gene Sequence for NOL10-LAP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>59521_59521_1_NOL10-LAP3_NOL10_chr2_10784445_ENST00000345985_LAP3_chr4_17583910_ENST00000226299_length(transcript)=2653nt_BP=987nt
CGGCGCCAGCGGCCGCACGCCGCGGAGCAGGGGCTCGGAGGTCCCGGGATTACGGTGCTCGAGCACGCTGGTGGGAAAGGACCCGGGACT
TGAACAGTGTTGTGCGGCGCCATGCAGGTCTCCAGCCTCAATGAGGTGAAGATTTACAGCCTCAGCTGCGGCAAGTCCCTTCCTGAGTGG
CTTTCTGATAGGAAGAAGAGAGCGCTACAGAAGAAAGATGTAGATGTCCGTAGGAGAATTGAACTTATTCAGGACTTTGAAATGCCTACT
GTGTGTACCACTATTAAGGTGTCAAAAGATGGACAGTACATTTTAGCAACTGGAACATATAAACCTCGGGTTCGATGTTATGACACCTAT
CAATTATCCTTGAAGTTTGAAAGGTGTTTAGATTCAGAAGTTGTCACCTTTGAAATTTTGTCTGATGACTACTCAAAGATTGTCTTCTTA
CATAATGATAGATACATTGAATTTCATTCGCAATCAGGTTTTTACTACAAAACCAGAATACCAAAGTTTGGGAGAGATTTCTCTTACCAC
TATCCATCCTGTGACTTGTACTTTGTTGGTGCAAGTTCTGAAGTTTATAGGTTAAACTTAGAACAAGGACGATACCTGAATCCTCTACAA
ACTGATGCTGCGGAGAATAATGTTTGTGACATAAATTCAGTGCATGGCTTGTTTGCCACAGGAACCATAGAGGGTAGAGTGGAGTGCTGG
GACCCAAGAACTCGAAACAGAGTTGGCCTGTTAGACTGCGCCTTAAACAGTGTCACAGCAGATTCAGAGATAAACAGTTTACCAACAATC
TCTGCTTTGAAATTTAATGGTGCCTTGACCATGGCAGTTGGAACAACCACAGGGCAGGGAAAAATATTTACTTCCTTGGAGCCAGAGCAT
GACCTTAATGATGTTTGTCTCTACCCCAACTCAGGCATGCTTCTGACGGCCAATGAAACCCCCAAGATGGGCATCTATTACATTCCAGAC
TTCCCCAGCGTGGTGCTAGTTGGCCTCGGCAAAAAGGCAGCTGGAATCGACGAACAGGAAAACTGGCATGAAGGCAAAGAAAACATCAGA
GCTGCTGTTGCAGCGGGGTGCAGGCAGATTCAAGACCTGGAGCTCTCGTCTGTGGAGGTGGATCCCTGTGGAGACGCTCAGGCTGCTGCG
GAGGGAGCGGTGCTTGGTCTCTATGAATACGATGACCTAAAGCAAAAAAAGAAGATGGCTGTGTCGGCAAAGCTCTATGGAAGTGGGGAT
CAGGAGGCCTGGCAGAAAGGAGTCCTGTTTGCTTCTGGGCAGAACTTGGCACGCCAATTGATGGAGACGCCAGCCAATGAGATGACGCCA
ACCAGATTTGCTGAAATTATTGAGAAGAATCTCAAAAGTGCTAGTAGTAAAACCGAGGTCCATATCAGACCCAAGTCTTGGATTGAGGAA
CAGGCAATGGGATCATTCCTCAGTGTGGCCAAAGGATCTGACGAGCCCCCAGTCTTCTTGGAAATTCACTACAAAGGCAGCCCCAATGCA
AACGAACCACCCCTGGTGTTTGTTGGGAAAGGAATTACCTTTGACAGTGGTGGTATCTCCATCAAGGCTTCTGCAAATATGGACCTCATG
AGGGCTGACATGGGAGGAGCTGCAACTATATGCTCAGCCATCGTGTCTGCTGCAAAGCTTAATTTGCCCATTAATATTATAGGTCTGGCC
CCTCTTTGTGAAAATATGCCCAGCGGCAAGGCCAACAAGCCGGGGGATGTTGTTAGAGCCAAAAACGGGAAGACCATCCAGGTTGATAAC
ACTGATGCTGAGGGGAGGCTCATACTGGCTGATGCGCTCTGTTACGCACACACGTTTAACCCGAAGGTCATCCTCAATGCCGCCACCTTA
ACAGGTGCCATGGATGTAGCTTTGGGATCAGGTGCCACTGGGGTCTTTACCAATTCATCCTGGCTCTGGAACAAACTCTTCGAGGCCAGC
ATTGAAACAGGGGACCGTGTCTGGAGGATGCCTCTCTTCGAACATTATACAAGACAGGTTGTAGATTGCCAGCTTGCTGATGTTAACAAC
ATTGGAAAATACAGATCTGCAGGAGCATGTACAGCTGCAGCATTCCTGAAAGAATTCGTAACTCATCCTAAGTGGGCACATTTAGACATA
GCAGGCGTGATGACCAACAAAGATGAAGTTCCCTATCTACGGAAAGGCATGACTGGGAGGCCCACAAGGACTCTCATTGAGTTCTTACTT
CGTTTCAGTCAAGACAATGCTTAGTTCAGATACTCAAAAATGTCTTCACTCTGTCTTAAATTGGACAGTTGAACTTAAAAGGTTTTTGAA
TAAATGGATGAAAATCTTTTAACGGAGACAAAGGATGGTATTTAAAAATGTAGAACACAATGAAATTTGTATGCCTTGATTTTTTTTTCA
TTTCACACAAAGATTTATAAAGGTAAAGTTAATATCTTACTTGATAAGGATTTTTAAGATACTCTATAAATGATTAAAATTTTTAGAACT
TCCTAATCACTTTTCAGAGTATATGTTTTTCATTGAGAAGCAAAATTGTAACTCAGATTTGTGATGCTAGGAACATGAGCAAACTGAAAA

>59521_59521_1_NOL10-LAP3_NOL10_chr2_10784445_ENST00000345985_LAP3_chr4_17583910_ENST00000226299_length(amino acids)=724AA_BP=296
MCGAMQVSSLNEVKIYSLSCGKSLPEWLSDRKKRALQKKDVDVRRRIELIQDFEMPTVCTTIKVSKDGQYILATGTYKPRVRCYDTYQLS
LKFERCLDSEVVTFEILSDDYSKIVFLHNDRYIEFHSQSGFYYKTRIPKFGRDFSYHYPSCDLYFVGASSEVYRLNLEQGRYLNPLQTDA
AENNVCDINSVHGLFATGTIEGRVECWDPRTRNRVGLLDCALNSVTADSEINSLPTISALKFNGALTMAVGTTTGQGKIFTSLEPEHDLN
DVCLYPNSGMLLTANETPKMGIYYIPDFPSVVLVGLGKKAAGIDEQENWHEGKENIRAAVAAGCRQIQDLELSSVEVDPCGDAQAAAEGA
VLGLYEYDDLKQKKKMAVSAKLYGSGDQEAWQKGVLFASGQNLARQLMETPANEMTPTRFAEIIEKNLKSASSKTEVHIRPKSWIEEQAM
GSFLSVAKGSDEPPVFLEIHYKGSPNANEPPLVFVGKGITFDSGGISIKASANMDLMRADMGGAATICSAIVSAAKLNLPINIIGLAPLC
ENMPSGKANKPGDVVRAKNGKTIQVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGVFTNSSWLWNKLFEASIET
GDRVWRMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGMTGRPTRTLIEFLLRFS

--------------------------------------------------------------
>59521_59521_2_NOL10-LAP3_NOL10_chr2_10784445_ENST00000345985_LAP3_chr4_17583910_ENST00000606142_length(transcript)=2619nt_BP=987nt
CGGCGCCAGCGGCCGCACGCCGCGGAGCAGGGGCTCGGAGGTCCCGGGATTACGGTGCTCGAGCACGCTGGTGGGAAAGGACCCGGGACT
TGAACAGTGTTGTGCGGCGCCATGCAGGTCTCCAGCCTCAATGAGGTGAAGATTTACAGCCTCAGCTGCGGCAAGTCCCTTCCTGAGTGG
CTTTCTGATAGGAAGAAGAGAGCGCTACAGAAGAAAGATGTAGATGTCCGTAGGAGAATTGAACTTATTCAGGACTTTGAAATGCCTACT
GTGTGTACCACTATTAAGGTGTCAAAAGATGGACAGTACATTTTAGCAACTGGAACATATAAACCTCGGGTTCGATGTTATGACACCTAT
CAATTATCCTTGAAGTTTGAAAGGTGTTTAGATTCAGAAGTTGTCACCTTTGAAATTTTGTCTGATGACTACTCAAAGATTGTCTTCTTA
CATAATGATAGATACATTGAATTTCATTCGCAATCAGGTTTTTACTACAAAACCAGAATACCAAAGTTTGGGAGAGATTTCTCTTACCAC
TATCCATCCTGTGACTTGTACTTTGTTGGTGCAAGTTCTGAAGTTTATAGGTTAAACTTAGAACAAGGACGATACCTGAATCCTCTACAA
ACTGATGCTGCGGAGAATAATGTTTGTGACATAAATTCAGTGCATGGCTTGTTTGCCACAGGAACCATAGAGGGTAGAGTGGAGTGCTGG
GACCCAAGAACTCGAAACAGAGTTGGCCTGTTAGACTGCGCCTTAAACAGTGTCACAGCAGATTCAGAGATAAACAGTTTACCAACAATC
TCTGCTTTGAAATTTAATGGTGCCTTGACCATGGCAGTTGGAACAACCACAGGGCAGGGAAAAATATTTACTTCCTTGGAGCCAGAGCAT
GACCTTAATGATGTTTGTCTCTACCCCAACTCAGGCATGCTTCTGACGGCCAATGAAACCCCCAAGATGGGCATCTATTACATTCCAGAC
TTCCCCAGCGTGGTGCTAGTTGGCCTCGGCAAAAAGGCAGCTGGAATCGACGAACAGGAAAACTGGCATGAAGGCAAAGAAAACATCAGA
GCTGCTGTTGCAGCGGGGTGCAGGCAGATTCAAGACCTGGAGCTCTCGTCTGTGGAGGTGGATCCCTGTGGAGACGCTCAGGCTGCTGCG
GAGGGAGCGGTGCTTGGTCTCTATGAATACGATGACCTAAAGCAAAAAAAGAAGATGGCTGTGTCGGCAAAGCTCTATGGAAGTGGGGAT
CAGGAGGCCTGGCAGAAAGGAGTCCTGTTTGCTTCTGGGCAGAACTTGGCACGCCAATTGATGGAGACGCCAGCCAATGAGATGACGCCA
ACCAGATTTGCTGAAATTATTGAGAAGAATCTCAAAAGTGCTAGTAGTAAAACCGAGGTCCATATCAGACCCAAGTCTTGGATTGAGGAA
CAGGCAATGGGATCATTCCTCAGTGTGGCCAAAGGATCTGACGAGCCCCCAGTCTTCTTGGAAATTCACTACAAAGGCAGCCCCAATGCA
AACGAACCACCCCTGGTGTTTGTTGGGAAAGGAATTACCTTTGACAGTGGTGGTATCTCCATCAAGGCTTCTGCAAATATGGACCTCATG
AGGGCTGACATGGGAGGAGCTGCAACTATATGCTCAGCCATCGTGTCTGCTGCAAAGCTTAATTTGCCCATTAATATTATAGGTCTGGCC
CCTCTTTGTGAAAATATGCCCAGCGGCAAGGCCAACAAGCCGGGGGATGTTGTTAGAGCCAAAAACGGGAAGACCATCCAGGTTGATAAC
ACTGATGCTGAGGGGAGGCTCATACTGGCTGATGCGCTCTGTTACGCACACACGTTTAACCCGAAGGTCATCCTCAATGCCGCCACCTTA
ACAGGTGCCATGGATGTAGCTTTGGGATCAGGTGCCACTGGGGTCTTTACCAATTCATCCTGGCTCTGGAACAAACTCTTCGAGGCCAGC
ATTGAAACAGGGGACCGTGTCTGGAGGATGCCTCTCTTCGAACATTATACAAGACAGGTTGTAGATTGCCAGCTTGCTGATGTTAACAAC
ATTGGAAAATACAGATCTGCAGGAGCATGTACAGCTGCAGCATTCCTGAAAGAATTCGTAACTCATCCTAAGTGGGCACATTTAGACATA
GCAGGCGTGATGACCAACAAAGATGAAGTTCCCTATCTACGGAAAGGCATGACTGGGAGGCCCACAAGGACTCTCATTGAGTTCTTACTT
CGTTTCAGTCAAGACAATGCTTAGTTCAGATACTCAAAAATGTCTTCACTCTGTCTTAAATTGGACAGTTGAACTTAAAAGGTTTTTGAA
TAAATGGATGAAAATCTTTTAACGGAGACAAAGGATGGTATTTAAAAATGTAGAACACAATGAAATTTGTATGCCTTGATTTTTTTTTCA
TTTCACACAAAGATTTATAAAGGTAAAGTTAATATCTTACTTGATAAGGATTTTTAAGATACTCTATAAATGATTAAAATTTTTAGAACT
TCCTAATCACTTTTCAGAGTATATGTTTTTCATTGAGAAGCAAAATTGTAACTCAGATTTGTGATGCTAGGAACATGAGCAAACTGAAAA

>59521_59521_2_NOL10-LAP3_NOL10_chr2_10784445_ENST00000345985_LAP3_chr4_17583910_ENST00000606142_length(amino acids)=724AA_BP=296
MCGAMQVSSLNEVKIYSLSCGKSLPEWLSDRKKRALQKKDVDVRRRIELIQDFEMPTVCTTIKVSKDGQYILATGTYKPRVRCYDTYQLS
LKFERCLDSEVVTFEILSDDYSKIVFLHNDRYIEFHSQSGFYYKTRIPKFGRDFSYHYPSCDLYFVGASSEVYRLNLEQGRYLNPLQTDA
AENNVCDINSVHGLFATGTIEGRVECWDPRTRNRVGLLDCALNSVTADSEINSLPTISALKFNGALTMAVGTTTGQGKIFTSLEPEHDLN
DVCLYPNSGMLLTANETPKMGIYYIPDFPSVVLVGLGKKAAGIDEQENWHEGKENIRAAVAAGCRQIQDLELSSVEVDPCGDAQAAAEGA
VLGLYEYDDLKQKKKMAVSAKLYGSGDQEAWQKGVLFASGQNLARQLMETPANEMTPTRFAEIIEKNLKSASSKTEVHIRPKSWIEEQAM
GSFLSVAKGSDEPPVFLEIHYKGSPNANEPPLVFVGKGITFDSGGISIKASANMDLMRADMGGAATICSAIVSAAKLNLPINIIGLAPLC
ENMPSGKANKPGDVVRAKNGKTIQVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGVFTNSSWLWNKLFEASIET
GDRVWRMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGMTGRPTRTLIEFLLRFS

--------------------------------------------------------------
>59521_59521_3_NOL10-LAP3_NOL10_chr2_10784445_ENST00000381685_LAP3_chr4_17583910_ENST00000226299_length(transcript)=2798nt_BP=1132nt
CCAGCGGCCGCACGCCGCGGAGCAGGGGCTCGGAGGTCCCGGGATTACGGTGCTCGAGCACGCTGGTGGGAAAGGACCCGGGACTTGAAC
AGTGTTGTGCGGCGCCATGCAGGTCTCCAGCCTCAATGAGGTGAAGATTTACAGCCTCAGCTGCGGCAAGTCCCTTCCTGAGTGGCTTTC
TGATAGGAAGAAGAGAGCGCTACAGAAGAAAGATGTAGATGTCCGTAGGAGAATTGAACTTATTCAGGACTTTGAAATGCCTACTGTGTG
TACCACTATTAAGGTGTCAAAAGATGGACAGTACATTTTAGCAACTGGAACATATAAACCTCGGGTTCGATGTTATGACACCTATCAATT
ATCCTTGAAGTTTGAAAGGTGTTTAGATTCAGAAGTTGTCACCTTTGAAATTTTGTCTGATGACTACTCAAAGATTGTCTTCTTACATAA
TGATAGATACATTGAATTTCATTCGCAATCAGGTTTTTACTACAAAACCAGAATACCAAAGTTTGGGAGAGATTTCTCTTACCACTATCC
ATCCTGTGACTTGTACTTTGTTGGTGCAAGTTCTGAAGTTTATAGGTTAAACTTAGAACAAGGACGATACCTGAATCCTCTACAAACTGA
TGCTGCGGAGAATAATGTTTGTGACATAAATTCAGTGCATGGCTTGTTTGCCACAGGAACCATAGAGGGTAGAGTGGAGTGCTGGGACCC
AAGAACTCGAAACAGAGTTGGCCTGTTAGACTGCGCCTTAAACAGTGTCACAGCAGATTCAGAGATAAACAGTTTACCAACAATCTCTGC
TTTGAAATTTAATGGTGCCTTGACCATGGCAGTTGGAACAACCACAGGGCAGGTTTTATTATATGACCTTCGATCTGATAAGCCATTGCT
AGTTAAAGATCACCAGTATGGGCTGCCCATTAAGTCCGTTCATTTCCAGGATTCATTAGATCTGATTTTGTCTGCTGACTCTCGAATTGT
CAAGATGTGGAATAAGAACTCCGGAAAAATATTTACTTCCTTGGAGCCAGAGCATGACCTTAATGATGTTTGTCTCTACCCCAACTCAGG
CATGCTTCTGACGGCCAATGAAACCCCCAAGATGGGCATCTATTACATTCCAGACTTCCCCAGCGTGGTGCTAGTTGGCCTCGGCAAAAA
GGCAGCTGGAATCGACGAACAGGAAAACTGGCATGAAGGCAAAGAAAACATCAGAGCTGCTGTTGCAGCGGGGTGCAGGCAGATTCAAGA
CCTGGAGCTCTCGTCTGTGGAGGTGGATCCCTGTGGAGACGCTCAGGCTGCTGCGGAGGGAGCGGTGCTTGGTCTCTATGAATACGATGA
CCTAAAGCAAAAAAAGAAGATGGCTGTGTCGGCAAAGCTCTATGGAAGTGGGGATCAGGAGGCCTGGCAGAAAGGAGTCCTGTTTGCTTC
TGGGCAGAACTTGGCACGCCAATTGATGGAGACGCCAGCCAATGAGATGACGCCAACCAGATTTGCTGAAATTATTGAGAAGAATCTCAA
AAGTGCTAGTAGTAAAACCGAGGTCCATATCAGACCCAAGTCTTGGATTGAGGAACAGGCAATGGGATCATTCCTCAGTGTGGCCAAAGG
ATCTGACGAGCCCCCAGTCTTCTTGGAAATTCACTACAAAGGCAGCCCCAATGCAAACGAACCACCCCTGGTGTTTGTTGGGAAAGGAAT
TACCTTTGACAGTGGTGGTATCTCCATCAAGGCTTCTGCAAATATGGACCTCATGAGGGCTGACATGGGAGGAGCTGCAACTATATGCTC
AGCCATCGTGTCTGCTGCAAAGCTTAATTTGCCCATTAATATTATAGGTCTGGCCCCTCTTTGTGAAAATATGCCCAGCGGCAAGGCCAA
CAAGCCGGGGGATGTTGTTAGAGCCAAAAACGGGAAGACCATCCAGGTTGATAACACTGATGCTGAGGGGAGGCTCATACTGGCTGATGC
GCTCTGTTACGCACACACGTTTAACCCGAAGGTCATCCTCAATGCCGCCACCTTAACAGGTGCCATGGATGTAGCTTTGGGATCAGGTGC
CACTGGGGTCTTTACCAATTCATCCTGGCTCTGGAACAAACTCTTCGAGGCCAGCATTGAAACAGGGGACCGTGTCTGGAGGATGCCTCT
CTTCGAACATTATACAAGACAGGTTGTAGATTGCCAGCTTGCTGATGTTAACAACATTGGAAAATACAGATCTGCAGGAGCATGTACAGC
TGCAGCATTCCTGAAAGAATTCGTAACTCATCCTAAGTGGGCACATTTAGACATAGCAGGCGTGATGACCAACAAAGATGAAGTTCCCTA
TCTACGGAAAGGCATGACTGGGAGGCCCACAAGGACTCTCATTGAGTTCTTACTTCGTTTCAGTCAAGACAATGCTTAGTTCAGATACTC
AAAAATGTCTTCACTCTGTCTTAAATTGGACAGTTGAACTTAAAAGGTTTTTGAATAAATGGATGAAAATCTTTTAACGGAGACAAAGGA
TGGTATTTAAAAATGTAGAACACAATGAAATTTGTATGCCTTGATTTTTTTTTCATTTCACACAAAGATTTATAAAGGTAAAGTTAATAT
CTTACTTGATAAGGATTTTTAAGATACTCTATAAATGATTAAAATTTTTAGAACTTCCTAATCACTTTTCAGAGTATATGTTTTTCATTG
AGAAGCAAAATTGTAACTCAGATTTGTGATGCTAGGAACATGAGCAAACTGAAAATTACTATGCACTTGTCAGAAACAATAAATGCAACT

>59521_59521_3_NOL10-LAP3_NOL10_chr2_10784445_ENST00000381685_LAP3_chr4_17583910_ENST00000226299_length(amino acids)=774AA_BP=346
MCGAMQVSSLNEVKIYSLSCGKSLPEWLSDRKKRALQKKDVDVRRRIELIQDFEMPTVCTTIKVSKDGQYILATGTYKPRVRCYDTYQLS
LKFERCLDSEVVTFEILSDDYSKIVFLHNDRYIEFHSQSGFYYKTRIPKFGRDFSYHYPSCDLYFVGASSEVYRLNLEQGRYLNPLQTDA
AENNVCDINSVHGLFATGTIEGRVECWDPRTRNRVGLLDCALNSVTADSEINSLPTISALKFNGALTMAVGTTTGQVLLYDLRSDKPLLV
KDHQYGLPIKSVHFQDSLDLILSADSRIVKMWNKNSGKIFTSLEPEHDLNDVCLYPNSGMLLTANETPKMGIYYIPDFPSVVLVGLGKKA
AGIDEQENWHEGKENIRAAVAAGCRQIQDLELSSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKKKMAVSAKLYGSGDQEAWQKGVLFASG
QNLARQLMETPANEMTPTRFAEIIEKNLKSASSKTEVHIRPKSWIEEQAMGSFLSVAKGSDEPPVFLEIHYKGSPNANEPPLVFVGKGIT
FDSGGISIKASANMDLMRADMGGAATICSAIVSAAKLNLPINIIGLAPLCENMPSGKANKPGDVVRAKNGKTIQVDNTDAEGRLILADAL
CYAHTFNPKVILNAATLTGAMDVALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAA

--------------------------------------------------------------
>59521_59521_4_NOL10-LAP3_NOL10_chr2_10784445_ENST00000381685_LAP3_chr4_17583910_ENST00000606142_length(transcript)=2764nt_BP=1132nt
CCAGCGGCCGCACGCCGCGGAGCAGGGGCTCGGAGGTCCCGGGATTACGGTGCTCGAGCACGCTGGTGGGAAAGGACCCGGGACTTGAAC
AGTGTTGTGCGGCGCCATGCAGGTCTCCAGCCTCAATGAGGTGAAGATTTACAGCCTCAGCTGCGGCAAGTCCCTTCCTGAGTGGCTTTC
TGATAGGAAGAAGAGAGCGCTACAGAAGAAAGATGTAGATGTCCGTAGGAGAATTGAACTTATTCAGGACTTTGAAATGCCTACTGTGTG
TACCACTATTAAGGTGTCAAAAGATGGACAGTACATTTTAGCAACTGGAACATATAAACCTCGGGTTCGATGTTATGACACCTATCAATT
ATCCTTGAAGTTTGAAAGGTGTTTAGATTCAGAAGTTGTCACCTTTGAAATTTTGTCTGATGACTACTCAAAGATTGTCTTCTTACATAA
TGATAGATACATTGAATTTCATTCGCAATCAGGTTTTTACTACAAAACCAGAATACCAAAGTTTGGGAGAGATTTCTCTTACCACTATCC
ATCCTGTGACTTGTACTTTGTTGGTGCAAGTTCTGAAGTTTATAGGTTAAACTTAGAACAAGGACGATACCTGAATCCTCTACAAACTGA
TGCTGCGGAGAATAATGTTTGTGACATAAATTCAGTGCATGGCTTGTTTGCCACAGGAACCATAGAGGGTAGAGTGGAGTGCTGGGACCC
AAGAACTCGAAACAGAGTTGGCCTGTTAGACTGCGCCTTAAACAGTGTCACAGCAGATTCAGAGATAAACAGTTTACCAACAATCTCTGC
TTTGAAATTTAATGGTGCCTTGACCATGGCAGTTGGAACAACCACAGGGCAGGTTTTATTATATGACCTTCGATCTGATAAGCCATTGCT
AGTTAAAGATCACCAGTATGGGCTGCCCATTAAGTCCGTTCATTTCCAGGATTCATTAGATCTGATTTTGTCTGCTGACTCTCGAATTGT
CAAGATGTGGAATAAGAACTCCGGAAAAATATTTACTTCCTTGGAGCCAGAGCATGACCTTAATGATGTTTGTCTCTACCCCAACTCAGG
CATGCTTCTGACGGCCAATGAAACCCCCAAGATGGGCATCTATTACATTCCAGACTTCCCCAGCGTGGTGCTAGTTGGCCTCGGCAAAAA
GGCAGCTGGAATCGACGAACAGGAAAACTGGCATGAAGGCAAAGAAAACATCAGAGCTGCTGTTGCAGCGGGGTGCAGGCAGATTCAAGA
CCTGGAGCTCTCGTCTGTGGAGGTGGATCCCTGTGGAGACGCTCAGGCTGCTGCGGAGGGAGCGGTGCTTGGTCTCTATGAATACGATGA
CCTAAAGCAAAAAAAGAAGATGGCTGTGTCGGCAAAGCTCTATGGAAGTGGGGATCAGGAGGCCTGGCAGAAAGGAGTCCTGTTTGCTTC
TGGGCAGAACTTGGCACGCCAATTGATGGAGACGCCAGCCAATGAGATGACGCCAACCAGATTTGCTGAAATTATTGAGAAGAATCTCAA
AAGTGCTAGTAGTAAAACCGAGGTCCATATCAGACCCAAGTCTTGGATTGAGGAACAGGCAATGGGATCATTCCTCAGTGTGGCCAAAGG
ATCTGACGAGCCCCCAGTCTTCTTGGAAATTCACTACAAAGGCAGCCCCAATGCAAACGAACCACCCCTGGTGTTTGTTGGGAAAGGAAT
TACCTTTGACAGTGGTGGTATCTCCATCAAGGCTTCTGCAAATATGGACCTCATGAGGGCTGACATGGGAGGAGCTGCAACTATATGCTC
AGCCATCGTGTCTGCTGCAAAGCTTAATTTGCCCATTAATATTATAGGTCTGGCCCCTCTTTGTGAAAATATGCCCAGCGGCAAGGCCAA
CAAGCCGGGGGATGTTGTTAGAGCCAAAAACGGGAAGACCATCCAGGTTGATAACACTGATGCTGAGGGGAGGCTCATACTGGCTGATGC
GCTCTGTTACGCACACACGTTTAACCCGAAGGTCATCCTCAATGCCGCCACCTTAACAGGTGCCATGGATGTAGCTTTGGGATCAGGTGC
CACTGGGGTCTTTACCAATTCATCCTGGCTCTGGAACAAACTCTTCGAGGCCAGCATTGAAACAGGGGACCGTGTCTGGAGGATGCCTCT
CTTCGAACATTATACAAGACAGGTTGTAGATTGCCAGCTTGCTGATGTTAACAACATTGGAAAATACAGATCTGCAGGAGCATGTACAGC
TGCAGCATTCCTGAAAGAATTCGTAACTCATCCTAAGTGGGCACATTTAGACATAGCAGGCGTGATGACCAACAAAGATGAAGTTCCCTA
TCTACGGAAAGGCATGACTGGGAGGCCCACAAGGACTCTCATTGAGTTCTTACTTCGTTTCAGTCAAGACAATGCTTAGTTCAGATACTC
AAAAATGTCTTCACTCTGTCTTAAATTGGACAGTTGAACTTAAAAGGTTTTTGAATAAATGGATGAAAATCTTTTAACGGAGACAAAGGA
TGGTATTTAAAAATGTAGAACACAATGAAATTTGTATGCCTTGATTTTTTTTTCATTTCACACAAAGATTTATAAAGGTAAAGTTAATAT
CTTACTTGATAAGGATTTTTAAGATACTCTATAAATGATTAAAATTTTTAGAACTTCCTAATCACTTTTCAGAGTATATGTTTTTCATTG

>59521_59521_4_NOL10-LAP3_NOL10_chr2_10784445_ENST00000381685_LAP3_chr4_17583910_ENST00000606142_length(amino acids)=774AA_BP=346
MCGAMQVSSLNEVKIYSLSCGKSLPEWLSDRKKRALQKKDVDVRRRIELIQDFEMPTVCTTIKVSKDGQYILATGTYKPRVRCYDTYQLS
LKFERCLDSEVVTFEILSDDYSKIVFLHNDRYIEFHSQSGFYYKTRIPKFGRDFSYHYPSCDLYFVGASSEVYRLNLEQGRYLNPLQTDA
AENNVCDINSVHGLFATGTIEGRVECWDPRTRNRVGLLDCALNSVTADSEINSLPTISALKFNGALTMAVGTTTGQVLLYDLRSDKPLLV
KDHQYGLPIKSVHFQDSLDLILSADSRIVKMWNKNSGKIFTSLEPEHDLNDVCLYPNSGMLLTANETPKMGIYYIPDFPSVVLVGLGKKA
AGIDEQENWHEGKENIRAAVAAGCRQIQDLELSSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKKKMAVSAKLYGSGDQEAWQKGVLFASG
QNLARQLMETPANEMTPTRFAEIIEKNLKSASSKTEVHIRPKSWIEEQAMGSFLSVAKGSDEPPVFLEIHYKGSPNANEPPLVFVGKGIT
FDSGGISIKASANMDLMRADMGGAATICSAIVSAAKLNLPINIIGLAPLCENMPSGKANKPGDVVRAKNGKTIQVDNTDAEGRLILADAL
CYAHTFNPKVILNAATLTGAMDVALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAA

--------------------------------------------------------------
>59521_59521_5_NOL10-LAP3_NOL10_chr2_10784445_ENST00000538384_LAP3_chr4_17583910_ENST00000226299_length(transcript)=2728nt_BP=1062nt
AGTCGGCGCCAGCGGCCGCACGCCGCGGAGCAGGGGCTCGGAGGTCCCGGGATTACGGTGCTCGAGCACGCTGGTGGGAAAGGACCCGGG
ACTTGAACAGTGTTGTGCGGCGCCATGCAGGTCTCCAGCCTCAATGAGGTGAAGATTTACAGCCTCAGCTGCGGCAAGTCCCTTCCTGAG
TGGCTTTCTGATAGGAAGAAGAGAGCGCTACAGAAGAAAGATGTAGATGTCCGTAGGAGAATTGAACTTATTCAGGACTTTGAAATGCCT
ACTGTGTGTACCACTATTAAGGTGTCAAAAGATGGACAGTACATTTTAGCAACTGTTGTCACCTTTGAAATTTTGTCTGATGACTACTCA
AAGATTGTCTTCTTACATAATGATAGATACATTGAATTTCATTCGCAATCAGGTTTTTACTACAAAACCAGAATACCAAAGTTTGGGAGA
GATTTCTCTTACCACTATCCATCCTGTGACTTGTACTTTGTTGGTGCAAGTTCTGAAGTTTATAGGTTAAACTTAGAACAAGGACGATAC
CTGAATCCTCTACAAACTGATGCTGCGGAGAATAATGTTTGTGACATAAATTCAGTGCATGGCTTGTTTGCCACAGGAACCATAGAGGGT
AGAGTGGAGTGCTGGGACCCAAGAACTCGAAACAGAGTTGGCCTGTTAGACTGCGCCTTAAACAGTGTCACAGCAGATTCAGAGATAAAC
AGTTTACCAACAATCTCTGCTTTGAAATTTAATGGTGCCTTGACCATGGCAGTTGGAACAACCACAGGGCAGGTTTTATTATATGACCTT
CGATCTGATAAGCCATTGCTAGTTAAAGATCACCAGTATGGGCTGCCCATTAAGTCCGTTCATTTCCAGGATTCATTAGATCTGATTTTG
TCTGCTGACTCTCGAATTGTCAAGATGTGGAATAAGAACTCCGGAAAAATATTTACTTCCTTGGAGCCAGAGCATGACCTTAATGATGTT
TGTCTCTACCCCAACTCAGGCATGCTTCTGACGGCCAATGAAACCCCCAAGATGGGCATCTATTACATTCCAGACTTCCCCAGCGTGGTG
CTAGTTGGCCTCGGCAAAAAGGCAGCTGGAATCGACGAACAGGAAAACTGGCATGAAGGCAAAGAAAACATCAGAGCTGCTGTTGCAGCG
GGGTGCAGGCAGATTCAAGACCTGGAGCTCTCGTCTGTGGAGGTGGATCCCTGTGGAGACGCTCAGGCTGCTGCGGAGGGAGCGGTGCTT
GGTCTCTATGAATACGATGACCTAAAGCAAAAAAAGAAGATGGCTGTGTCGGCAAAGCTCTATGGAAGTGGGGATCAGGAGGCCTGGCAG
AAAGGAGTCCTGTTTGCTTCTGGGCAGAACTTGGCACGCCAATTGATGGAGACGCCAGCCAATGAGATGACGCCAACCAGATTTGCTGAA
ATTATTGAGAAGAATCTCAAAAGTGCTAGTAGTAAAACCGAGGTCCATATCAGACCCAAGTCTTGGATTGAGGAACAGGCAATGGGATCA
TTCCTCAGTGTGGCCAAAGGATCTGACGAGCCCCCAGTCTTCTTGGAAATTCACTACAAAGGCAGCCCCAATGCAAACGAACCACCCCTG
GTGTTTGTTGGGAAAGGAATTACCTTTGACAGTGGTGGTATCTCCATCAAGGCTTCTGCAAATATGGACCTCATGAGGGCTGACATGGGA
GGAGCTGCAACTATATGCTCAGCCATCGTGTCTGCTGCAAAGCTTAATTTGCCCATTAATATTATAGGTCTGGCCCCTCTTTGTGAAAAT
ATGCCCAGCGGCAAGGCCAACAAGCCGGGGGATGTTGTTAGAGCCAAAAACGGGAAGACCATCCAGGTTGATAACACTGATGCTGAGGGG
AGGCTCATACTGGCTGATGCGCTCTGTTACGCACACACGTTTAACCCGAAGGTCATCCTCAATGCCGCCACCTTAACAGGTGCCATGGAT
GTAGCTTTGGGATCAGGTGCCACTGGGGTCTTTACCAATTCATCCTGGCTCTGGAACAAACTCTTCGAGGCCAGCATTGAAACAGGGGAC
CGTGTCTGGAGGATGCCTCTCTTCGAACATTATACAAGACAGGTTGTAGATTGCCAGCTTGCTGATGTTAACAACATTGGAAAATACAGA
TCTGCAGGAGCATGTACAGCTGCAGCATTCCTGAAAGAATTCGTAACTCATCCTAAGTGGGCACATTTAGACATAGCAGGCGTGATGACC
AACAAAGATGAAGTTCCCTATCTACGGAAAGGCATGACTGGGAGGCCCACAAGGACTCTCATTGAGTTCTTACTTCGTTTCAGTCAAGAC
AATGCTTAGTTCAGATACTCAAAAATGTCTTCACTCTGTCTTAAATTGGACAGTTGAACTTAAAAGGTTTTTGAATAAATGGATGAAAAT
CTTTTAACGGAGACAAAGGATGGTATTTAAAAATGTAGAACACAATGAAATTTGTATGCCTTGATTTTTTTTTCATTTCACACAAAGATT
TATAAAGGTAAAGTTAATATCTTACTTGATAAGGATTTTTAAGATACTCTATAAATGATTAAAATTTTTAGAACTTCCTAATCACTTTTC
AGAGTATATGTTTTTCATTGAGAAGCAAAATTGTAACTCAGATTTGTGATGCTAGGAACATGAGCAAACTGAAAATTACTATGCACTTGT

>59521_59521_5_NOL10-LAP3_NOL10_chr2_10784445_ENST00000538384_LAP3_chr4_17583910_ENST00000226299_length(amino acids)=748AA_BP=320
MCGAMQVSSLNEVKIYSLSCGKSLPEWLSDRKKRALQKKDVDVRRRIELIQDFEMPTVCTTIKVSKDGQYILATVVTFEILSDDYSKIVF
LHNDRYIEFHSQSGFYYKTRIPKFGRDFSYHYPSCDLYFVGASSEVYRLNLEQGRYLNPLQTDAAENNVCDINSVHGLFATGTIEGRVEC
WDPRTRNRVGLLDCALNSVTADSEINSLPTISALKFNGALTMAVGTTTGQVLLYDLRSDKPLLVKDHQYGLPIKSVHFQDSLDLILSADS
RIVKMWNKNSGKIFTSLEPEHDLNDVCLYPNSGMLLTANETPKMGIYYIPDFPSVVLVGLGKKAAGIDEQENWHEGKENIRAAVAAGCRQ
IQDLELSSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKKKMAVSAKLYGSGDQEAWQKGVLFASGQNLARQLMETPANEMTPTRFAEIIEK
NLKSASSKTEVHIRPKSWIEEQAMGSFLSVAKGSDEPPVFLEIHYKGSPNANEPPLVFVGKGITFDSGGISIKASANMDLMRADMGGAAT
ICSAIVSAAKLNLPINIIGLAPLCENMPSGKANKPGDVVRAKNGKTIQVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALG
SGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDE

--------------------------------------------------------------
>59521_59521_6_NOL10-LAP3_NOL10_chr2_10784445_ENST00000538384_LAP3_chr4_17583910_ENST00000606142_length(transcript)=2694nt_BP=1062nt
AGTCGGCGCCAGCGGCCGCACGCCGCGGAGCAGGGGCTCGGAGGTCCCGGGATTACGGTGCTCGAGCACGCTGGTGGGAAAGGACCCGGG
ACTTGAACAGTGTTGTGCGGCGCCATGCAGGTCTCCAGCCTCAATGAGGTGAAGATTTACAGCCTCAGCTGCGGCAAGTCCCTTCCTGAG
TGGCTTTCTGATAGGAAGAAGAGAGCGCTACAGAAGAAAGATGTAGATGTCCGTAGGAGAATTGAACTTATTCAGGACTTTGAAATGCCT
ACTGTGTGTACCACTATTAAGGTGTCAAAAGATGGACAGTACATTTTAGCAACTGTTGTCACCTTTGAAATTTTGTCTGATGACTACTCA
AAGATTGTCTTCTTACATAATGATAGATACATTGAATTTCATTCGCAATCAGGTTTTTACTACAAAACCAGAATACCAAAGTTTGGGAGA
GATTTCTCTTACCACTATCCATCCTGTGACTTGTACTTTGTTGGTGCAAGTTCTGAAGTTTATAGGTTAAACTTAGAACAAGGACGATAC
CTGAATCCTCTACAAACTGATGCTGCGGAGAATAATGTTTGTGACATAAATTCAGTGCATGGCTTGTTTGCCACAGGAACCATAGAGGGT
AGAGTGGAGTGCTGGGACCCAAGAACTCGAAACAGAGTTGGCCTGTTAGACTGCGCCTTAAACAGTGTCACAGCAGATTCAGAGATAAAC
AGTTTACCAACAATCTCTGCTTTGAAATTTAATGGTGCCTTGACCATGGCAGTTGGAACAACCACAGGGCAGGTTTTATTATATGACCTT
CGATCTGATAAGCCATTGCTAGTTAAAGATCACCAGTATGGGCTGCCCATTAAGTCCGTTCATTTCCAGGATTCATTAGATCTGATTTTG
TCTGCTGACTCTCGAATTGTCAAGATGTGGAATAAGAACTCCGGAAAAATATTTACTTCCTTGGAGCCAGAGCATGACCTTAATGATGTT
TGTCTCTACCCCAACTCAGGCATGCTTCTGACGGCCAATGAAACCCCCAAGATGGGCATCTATTACATTCCAGACTTCCCCAGCGTGGTG
CTAGTTGGCCTCGGCAAAAAGGCAGCTGGAATCGACGAACAGGAAAACTGGCATGAAGGCAAAGAAAACATCAGAGCTGCTGTTGCAGCG
GGGTGCAGGCAGATTCAAGACCTGGAGCTCTCGTCTGTGGAGGTGGATCCCTGTGGAGACGCTCAGGCTGCTGCGGAGGGAGCGGTGCTT
GGTCTCTATGAATACGATGACCTAAAGCAAAAAAAGAAGATGGCTGTGTCGGCAAAGCTCTATGGAAGTGGGGATCAGGAGGCCTGGCAG
AAAGGAGTCCTGTTTGCTTCTGGGCAGAACTTGGCACGCCAATTGATGGAGACGCCAGCCAATGAGATGACGCCAACCAGATTTGCTGAA
ATTATTGAGAAGAATCTCAAAAGTGCTAGTAGTAAAACCGAGGTCCATATCAGACCCAAGTCTTGGATTGAGGAACAGGCAATGGGATCA
TTCCTCAGTGTGGCCAAAGGATCTGACGAGCCCCCAGTCTTCTTGGAAATTCACTACAAAGGCAGCCCCAATGCAAACGAACCACCCCTG
GTGTTTGTTGGGAAAGGAATTACCTTTGACAGTGGTGGTATCTCCATCAAGGCTTCTGCAAATATGGACCTCATGAGGGCTGACATGGGA
GGAGCTGCAACTATATGCTCAGCCATCGTGTCTGCTGCAAAGCTTAATTTGCCCATTAATATTATAGGTCTGGCCCCTCTTTGTGAAAAT
ATGCCCAGCGGCAAGGCCAACAAGCCGGGGGATGTTGTTAGAGCCAAAAACGGGAAGACCATCCAGGTTGATAACACTGATGCTGAGGGG
AGGCTCATACTGGCTGATGCGCTCTGTTACGCACACACGTTTAACCCGAAGGTCATCCTCAATGCCGCCACCTTAACAGGTGCCATGGAT
GTAGCTTTGGGATCAGGTGCCACTGGGGTCTTTACCAATTCATCCTGGCTCTGGAACAAACTCTTCGAGGCCAGCATTGAAACAGGGGAC
CGTGTCTGGAGGATGCCTCTCTTCGAACATTATACAAGACAGGTTGTAGATTGCCAGCTTGCTGATGTTAACAACATTGGAAAATACAGA
TCTGCAGGAGCATGTACAGCTGCAGCATTCCTGAAAGAATTCGTAACTCATCCTAAGTGGGCACATTTAGACATAGCAGGCGTGATGACC
AACAAAGATGAAGTTCCCTATCTACGGAAAGGCATGACTGGGAGGCCCACAAGGACTCTCATTGAGTTCTTACTTCGTTTCAGTCAAGAC
AATGCTTAGTTCAGATACTCAAAAATGTCTTCACTCTGTCTTAAATTGGACAGTTGAACTTAAAAGGTTTTTGAATAAATGGATGAAAAT
CTTTTAACGGAGACAAAGGATGGTATTTAAAAATGTAGAACACAATGAAATTTGTATGCCTTGATTTTTTTTTCATTTCACACAAAGATT
TATAAAGGTAAAGTTAATATCTTACTTGATAAGGATTTTTAAGATACTCTATAAATGATTAAAATTTTTAGAACTTCCTAATCACTTTTC

>59521_59521_6_NOL10-LAP3_NOL10_chr2_10784445_ENST00000538384_LAP3_chr4_17583910_ENST00000606142_length(amino acids)=748AA_BP=320
MCGAMQVSSLNEVKIYSLSCGKSLPEWLSDRKKRALQKKDVDVRRRIELIQDFEMPTVCTTIKVSKDGQYILATVVTFEILSDDYSKIVF
LHNDRYIEFHSQSGFYYKTRIPKFGRDFSYHYPSCDLYFVGASSEVYRLNLEQGRYLNPLQTDAAENNVCDINSVHGLFATGTIEGRVEC
WDPRTRNRVGLLDCALNSVTADSEINSLPTISALKFNGALTMAVGTTTGQVLLYDLRSDKPLLVKDHQYGLPIKSVHFQDSLDLILSADS
RIVKMWNKNSGKIFTSLEPEHDLNDVCLYPNSGMLLTANETPKMGIYYIPDFPSVVLVGLGKKAAGIDEQENWHEGKENIRAAVAAGCRQ
IQDLELSSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKKKMAVSAKLYGSGDQEAWQKGVLFASGQNLARQLMETPANEMTPTRFAEIIEK
NLKSASSKTEVHIRPKSWIEEQAMGSFLSVAKGSDEPPVFLEIHYKGSPNANEPPLVFVGKGITFDSGGISIKASANMDLMRADMGGAAT
ICSAIVSAAKLNLPINIIGLAPLCENMPSGKANKPGDVVRAKNGKTIQVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALG
SGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NOL10-LAP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NOL10-LAP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NOL10-LAP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource