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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NOL4-DTNA (FusionGDB2 ID:59547)

Fusion Gene Summary for NOL4-DTNA

check button Fusion gene summary
Fusion gene informationFusion gene name: NOL4-DTNA
Fusion gene ID: 59547
HgeneTgene
Gene symbol

NOL4

DTNA

Gene ID

8715

1837

Gene namenucleolar protein 4dystrobrevin alpha
SynonymsCT125|HRIHFB2255|NOLPD18S892E|DRP3|DTN|DTN-A|LVNC1
Cytomap

18q12.1

18q12.1

Type of geneprotein-codingprotein-coding
Descriptionnucleolar protein 4cancer/testis antigen 125nucleolar localized proteindystrobrevin alphadystrophin-related protein 3
Modification date2020031320200313
UniProtAcc

O94818

Q9Y4J8

Ensembl transtripts involved in fusion geneENST00000538587, ENST00000535475, 
ENST00000261592, ENST00000269185, 
ENST00000535384, ENST00000589544, 
ENST00000590846, 		ENST00000269191, 
ENST00000348997, ENST00000399097, 
ENST00000399113, ENST00000444659, 
ENST00000597599, ENST00000598142, 
ENST00000598774, ENST00000269192, 
ENST00000556414, ENST00000590831, 
ENST00000591182, ENST00000592449, 
ENST00000597674, ENST00000599844, 
ENST00000601125, ENST00000269190, 
ENST00000283365, ENST00000315456, 
ENST00000399121, ENST00000554864, 
ENST00000595022, ENST00000596745, 
ENST00000598334, 
Fusion gene scores* DoF score5 X 5 X 2=507 X 7 X 3=147
# samples 57
** MAII scorelog2(5/50*10)=0log2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NOL4 [Title/Abstract] AND DTNA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNOL4(31801984)-DTNA(32374001), # samples:1
Anticipated loss of major functional domain due to fusion event.NOL4-DTNA seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NOL4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DTNA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-14-1034-02BNOL4chr18

31801984

-DTNAchr18

32374001

+


Top

Fusion Gene ORF analysis for NOL4-DTNA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000538587ENST00000269191NOL4chr18

31801984

-DTNAchr18

32374001

+
5CDS-5UTRENST00000538587ENST00000348997NOL4chr18

31801984

-DTNAchr18

32374001

+
5CDS-5UTRENST00000538587ENST00000399097NOL4chr18

31801984

-DTNAchr18

32374001

+
5CDS-5UTRENST00000538587ENST00000399113NOL4chr18

31801984

-DTNAchr18

32374001

+
5CDS-5UTRENST00000538587ENST00000444659NOL4chr18

31801984

-DTNAchr18

32374001

+
5CDS-5UTRENST00000538587ENST00000597599NOL4chr18

31801984

-DTNAchr18

32374001

+
5CDS-5UTRENST00000538587ENST00000598142NOL4chr18

31801984

-DTNAchr18

32374001

+
5CDS-5UTRENST00000538587ENST00000598774NOL4chr18

31801984

-DTNAchr18

32374001

+
5CDS-intronENST00000538587ENST00000269192NOL4chr18

31801984

-DTNAchr18

32374001

+
5CDS-intronENST00000538587ENST00000556414NOL4chr18

31801984

-DTNAchr18

32374001

+
5CDS-intronENST00000538587ENST00000590831NOL4chr18

31801984

-DTNAchr18

32374001

+
5CDS-intronENST00000538587ENST00000591182NOL4chr18

31801984

-DTNAchr18

32374001

+
5CDS-intronENST00000538587ENST00000592449NOL4chr18

31801984

-DTNAchr18

32374001

+
5CDS-intronENST00000538587ENST00000597674NOL4chr18

31801984

-DTNAchr18

32374001

+
5CDS-intronENST00000538587ENST00000599844NOL4chr18

31801984

-DTNAchr18

32374001

+
5CDS-intronENST00000538587ENST00000601125NOL4chr18

31801984

-DTNAchr18

32374001

+
5UTR-3CDSENST00000535475ENST00000269190NOL4chr18

31801984

-DTNAchr18

32374001

+
5UTR-3CDSENST00000535475ENST00000283365NOL4chr18

31801984

-DTNAchr18

32374001

+
5UTR-3CDSENST00000535475ENST00000315456NOL4chr18

31801984

-DTNAchr18

32374001

+
5UTR-3CDSENST00000535475ENST00000399121NOL4chr18

31801984

-DTNAchr18

32374001

+
5UTR-3CDSENST00000535475ENST00000554864NOL4chr18

31801984

-DTNAchr18

32374001

+
5UTR-3CDSENST00000535475ENST00000595022NOL4chr18

31801984

-DTNAchr18

32374001

+
5UTR-3CDSENST00000535475ENST00000596745NOL4chr18

31801984

-DTNAchr18

32374001

+
5UTR-3CDSENST00000535475ENST00000598334NOL4chr18

31801984

-DTNAchr18

32374001

+
5UTR-5UTRENST00000535475ENST00000269191NOL4chr18

31801984

-DTNAchr18

32374001

+
5UTR-5UTRENST00000535475ENST00000348997NOL4chr18

31801984

-DTNAchr18

32374001

+
5UTR-5UTRENST00000535475ENST00000399097NOL4chr18

31801984

-DTNAchr18

32374001

+
5UTR-5UTRENST00000535475ENST00000399113NOL4chr18

31801984

-DTNAchr18

32374001

+
5UTR-5UTRENST00000535475ENST00000444659NOL4chr18

31801984

-DTNAchr18

32374001

+
5UTR-5UTRENST00000535475ENST00000597599NOL4chr18

31801984

-DTNAchr18

32374001

+
5UTR-5UTRENST00000535475ENST00000598142NOL4chr18

31801984

-DTNAchr18

32374001

+
5UTR-5UTRENST00000535475ENST00000598774NOL4chr18

31801984

-DTNAchr18

32374001

+
5UTR-intronENST00000535475ENST00000269192NOL4chr18

31801984

-DTNAchr18

32374001

+
5UTR-intronENST00000535475ENST00000556414NOL4chr18

31801984

-DTNAchr18

32374001

+
5UTR-intronENST00000535475ENST00000590831NOL4chr18

31801984

-DTNAchr18

32374001

+
5UTR-intronENST00000535475ENST00000591182NOL4chr18

31801984

-DTNAchr18

32374001

+
5UTR-intronENST00000535475ENST00000592449NOL4chr18

31801984

-DTNAchr18

32374001

+
5UTR-intronENST00000535475ENST00000597674NOL4chr18

31801984

-DTNAchr18

32374001

+
5UTR-intronENST00000535475ENST00000599844NOL4chr18

31801984

-DTNAchr18

32374001

+
5UTR-intronENST00000535475ENST00000601125NOL4chr18

31801984

-DTNAchr18

32374001

+
Frame-shiftENST00000538587ENST00000269190NOL4chr18

31801984

-DTNAchr18

32374001

+
Frame-shiftENST00000538587ENST00000283365NOL4chr18

31801984

-DTNAchr18

32374001

+
Frame-shiftENST00000538587ENST00000315456NOL4chr18

31801984

-DTNAchr18

32374001

+
Frame-shiftENST00000538587ENST00000399121NOL4chr18

31801984

-DTNAchr18

32374001

+
Frame-shiftENST00000538587ENST00000554864NOL4chr18

31801984

-DTNAchr18

32374001

+
Frame-shiftENST00000538587ENST00000595022NOL4chr18

31801984

-DTNAchr18

32374001

+
Frame-shiftENST00000538587ENST00000596745NOL4chr18

31801984

-DTNAchr18

32374001

+
Frame-shiftENST00000538587ENST00000598334NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000261592ENST00000269190NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000261592ENST00000283365NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000261592ENST00000315456NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000261592ENST00000399121NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000261592ENST00000554864NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000261592ENST00000595022NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000261592ENST00000596745NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000261592ENST00000598334NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000269185ENST00000269190NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000269185ENST00000283365NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000269185ENST00000315456NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000269185ENST00000399121NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000269185ENST00000554864NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000269185ENST00000595022NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000269185ENST00000596745NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000269185ENST00000598334NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000535384ENST00000269190NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000535384ENST00000283365NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000535384ENST00000315456NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000535384ENST00000399121NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000535384ENST00000554864NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000535384ENST00000595022NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000535384ENST00000596745NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000535384ENST00000598334NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000589544ENST00000269190NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000589544ENST00000283365NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000589544ENST00000315456NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000589544ENST00000399121NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000589544ENST00000554864NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000589544ENST00000595022NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000589544ENST00000596745NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000589544ENST00000598334NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000590846ENST00000269190NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000590846ENST00000283365NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000590846ENST00000315456NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000590846ENST00000399121NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000590846ENST00000554864NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000590846ENST00000595022NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000590846ENST00000596745NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-3CDSENST00000590846ENST00000598334NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000261592ENST00000269191NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000261592ENST00000348997NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000261592ENST00000399097NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000261592ENST00000399113NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000261592ENST00000444659NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000261592ENST00000597599NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000261592ENST00000598142NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000261592ENST00000598774NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000269185ENST00000269191NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000269185ENST00000348997NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000269185ENST00000399097NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000269185ENST00000399113NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000269185ENST00000444659NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000269185ENST00000597599NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000269185ENST00000598142NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000269185ENST00000598774NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000535384ENST00000269191NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000535384ENST00000348997NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000535384ENST00000399097NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000535384ENST00000399113NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000535384ENST00000444659NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000535384ENST00000597599NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000535384ENST00000598142NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000535384ENST00000598774NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000589544ENST00000269191NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000589544ENST00000348997NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000589544ENST00000399097NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000589544ENST00000399113NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000589544ENST00000444659NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000589544ENST00000597599NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000589544ENST00000598142NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000589544ENST00000598774NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000590846ENST00000269191NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000590846ENST00000348997NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000590846ENST00000399097NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000590846ENST00000399113NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000590846ENST00000444659NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000590846ENST00000597599NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000590846ENST00000598142NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-5UTRENST00000590846ENST00000598774NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000261592ENST00000269192NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000261592ENST00000556414NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000261592ENST00000590831NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000261592ENST00000591182NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000261592ENST00000592449NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000261592ENST00000597674NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000261592ENST00000599844NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000261592ENST00000601125NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000269185ENST00000269192NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000269185ENST00000556414NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000269185ENST00000590831NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000269185ENST00000591182NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000269185ENST00000592449NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000269185ENST00000597674NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000269185ENST00000599844NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000269185ENST00000601125NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000535384ENST00000269192NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000535384ENST00000556414NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000535384ENST00000590831NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000535384ENST00000591182NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000535384ENST00000592449NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000535384ENST00000597674NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000535384ENST00000599844NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000535384ENST00000601125NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000589544ENST00000269192NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000589544ENST00000556414NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000589544ENST00000590831NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000589544ENST00000591182NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000589544ENST00000592449NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000589544ENST00000597674NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000589544ENST00000599844NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000589544ENST00000601125NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000590846ENST00000269192NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000590846ENST00000556414NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000590846ENST00000590831NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000590846ENST00000591182NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000590846ENST00000592449NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000590846ENST00000597674NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000590846ENST00000599844NOL4chr18

31801984

-DTNAchr18

32374001

+
intron-intronENST00000590846ENST00000601125NOL4chr18

31801984

-DTNAchr18

32374001

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NOL4-DTNA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NOL4chr1831801983-DTNAchr1832374000+0.0010387770.9989612
NOL4chr1831801983-DTNAchr1832374000+0.0010387770.9989612

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NOL4-DTNA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:31801984/:32374001)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NOL4

O94818

DTNA

Q9Y4J8

FUNCTION: May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NOL4-DTNA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NOL4-DTNA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NOL4-DTNA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NOL4-DTNA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource