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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGAP15-ZEB2 (FusionGDB2 ID:5955)

Fusion Gene Summary for ARHGAP15-ZEB2

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP15-ZEB2
Fusion gene ID: 5955
HgeneTgene
Gene symbol

ARHGAP15

ZEB2

Gene ID

55843

9839

Gene nameRho GTPase activating protein 15zinc finger E-box binding homeobox 2
SynonymsBM046HSPC082|SIP-1|SIP1|SMADIP1|ZFHX1B
Cytomap

2q22.2-q22.3

2q22.3

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 15rho-type GTPase-activating protein 15zinc finger E-box-binding homeobox 2SMAD interacting protein 1Smad-interacting protein 1zinc finger homeobox 1b
Modification date2020031320200329
UniProtAcc

Q53QZ3

.
Ensembl transtripts involved in fusion geneENST00000295095, ENST00000409869, 
ENST00000473426, 		ENST00000462355, 
ENST00000465070, ENST00000470879, 
ENST00000493689, ENST00000303660, 
ENST00000409487, ENST00000539609, 
ENST00000558170, 
Fusion gene scores* DoF score15 X 13 X 5=9755 X 5 X 3=75
# samples 165
** MAII scorelog2(16/975*10)=-2.60733031374961
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP15 [Title/Abstract] AND ZEB2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZEB2(145274845)-ARHGAP15(144460988), # samples:3
ARHGAP15(144314054)-ZEB2(145187593), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGAP15

GO:0008360

regulation of cell shape

12650940

TgeneZEB2

GO:0000122

negative regulation of transcription by RNA polymerase II

12837246|20516212


check buttonFusion gene breakpoints across ARHGAP15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZEB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4J9-01AARHGAP15chr2

144314054

+ZEB2chr2

145187593

-


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Fusion Gene ORF analysis for ARHGAP15-ZEB2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000295095ENST00000462355ARHGAP15chr2

144314054

+ZEB2chr2

145187593

-
5CDS-intronENST00000295095ENST00000465070ARHGAP15chr2

144314054

+ZEB2chr2

145187593

-
5CDS-intronENST00000295095ENST00000470879ARHGAP15chr2

144314054

+ZEB2chr2

145187593

-
5CDS-intronENST00000295095ENST00000493689ARHGAP15chr2

144314054

+ZEB2chr2

145187593

-
In-frameENST00000295095ENST00000303660ARHGAP15chr2

144314054

+ZEB2chr2

145187593

-
In-frameENST00000295095ENST00000409487ARHGAP15chr2

144314054

+ZEB2chr2

145187593

-
In-frameENST00000295095ENST00000539609ARHGAP15chr2

144314054

+ZEB2chr2

145187593

-
In-frameENST00000295095ENST00000558170ARHGAP15chr2

144314054

+ZEB2chr2

145187593

-
intron-3CDSENST00000409869ENST00000303660ARHGAP15chr2

144314054

+ZEB2chr2

145187593

-
intron-3CDSENST00000409869ENST00000409487ARHGAP15chr2

144314054

+ZEB2chr2

145187593

-
intron-3CDSENST00000409869ENST00000539609ARHGAP15chr2

144314054

+ZEB2chr2

145187593

-
intron-3CDSENST00000409869ENST00000558170ARHGAP15chr2

144314054

+ZEB2chr2

145187593

-
intron-3CDSENST00000473426ENST00000303660ARHGAP15chr2

144314054

+ZEB2chr2

145187593

-
intron-3CDSENST00000473426ENST00000409487ARHGAP15chr2

144314054

+ZEB2chr2

145187593

-
intron-3CDSENST00000473426ENST00000539609ARHGAP15chr2

144314054

+ZEB2chr2

145187593

-
intron-3CDSENST00000473426ENST00000558170ARHGAP15chr2

144314054

+ZEB2chr2

145187593

-
intron-intronENST00000409869ENST00000462355ARHGAP15chr2

144314054

+ZEB2chr2

145187593

-
intron-intronENST00000409869ENST00000465070ARHGAP15chr2

144314054

+ZEB2chr2

145187593

-
intron-intronENST00000409869ENST00000470879ARHGAP15chr2

144314054

+ZEB2chr2

145187593

-
intron-intronENST00000409869ENST00000493689ARHGAP15chr2

144314054

+ZEB2chr2

145187593

-
intron-intronENST00000473426ENST00000462355ARHGAP15chr2

144314054

+ZEB2chr2

145187593

-
intron-intronENST00000473426ENST00000465070ARHGAP15chr2

144314054

+ZEB2chr2

145187593

-
intron-intronENST00000473426ENST00000470879ARHGAP15chr2

144314054

+ZEB2chr2

145187593

-
intron-intronENST00000473426ENST00000493689ARHGAP15chr2

144314054

+ZEB2chr2

145187593

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000295095ARHGAP15chr2144314054+ENST00000558170ZEB2chr2145187593-10112117016747411524
ENST00000295095ARHGAP15chr2144314054+ENST00000409487ZEB2chr2145187593-6192117016747411524
ENST00000295095ARHGAP15chr2144314054+ENST00000303660ZEB2chr2145187593-6179117016747411524
ENST00000295095ARHGAP15chr2144314054+ENST00000539609ZEB2chr2145187593-6104117016746691500

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000295095ENST00000558170ARHGAP15chr2144314054+ZEB2chr2145187593-0.0001669650.999833
ENST00000295095ENST00000409487ARHGAP15chr2144314054+ZEB2chr2145187593-0.0003042980.9996958
ENST00000295095ENST00000303660ARHGAP15chr2144314054+ZEB2chr2145187593-0.0003081340.99969184
ENST00000295095ENST00000539609ARHGAP15chr2144314054+ZEB2chr2145187593-0.0002971750.99970275

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Fusion Genomic Features for ARHGAP15-ZEB2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARHGAP15-ZEB2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:145274845/chr2:144460988)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP15

Q53QZ3

.
FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction. {ECO:0000269|PubMed:12650940}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP15chr2:144314054chr2:145187593ENST00000295095+111479_189334476.0DomainPH
TgeneZEB2chr2:144314054chr2:145187593ENST000003036601101084_1214241215.0Compositional biasNote=Glu-rich (acidic)
TgeneZEB2chr2:144314054chr2:145187593ENST000004094871101084_1214241215.0Compositional biasNote=Glu-rich (acidic)
TgeneZEB2chr2:144314054chr2:145187593ENST00000539609191084_1214241191.0Compositional biasNote=Glu-rich (acidic)
TgeneZEB2chr2:144314054chr2:145187593ENST000005581701101084_1214241215.0Compositional biasNote=Glu-rich (acidic)
TgeneZEB2chr2:144314054chr2:145187593ENST00000303660110644_703241215.0DNA bindingNote=Homeobox%3B atypical
TgeneZEB2chr2:144314054chr2:145187593ENST00000409487110644_703241215.0DNA bindingNote=Homeobox%3B atypical
TgeneZEB2chr2:144314054chr2:145187593ENST0000053960919644_703241191.0DNA bindingNote=Homeobox%3B atypical
TgeneZEB2chr2:144314054chr2:145187593ENST00000558170110644_703241215.0DNA bindingNote=Homeobox%3B atypical
TgeneZEB2chr2:144314054chr2:145187593ENST00000303660110437_487241215.0RegionSMAD-MH2 binding domain
TgeneZEB2chr2:144314054chr2:145187593ENST00000409487110437_487241215.0RegionSMAD-MH2 binding domain
TgeneZEB2chr2:144314054chr2:145187593ENST0000053960919437_487241191.0RegionSMAD-MH2 binding domain
TgeneZEB2chr2:144314054chr2:145187593ENST00000558170110437_487241215.0RegionSMAD-MH2 binding domain
TgeneZEB2chr2:144314054chr2:145187593ENST000003036601101027_1049241215.0Zinc fingerC2H2-type 7
TgeneZEB2chr2:144314054chr2:145187593ENST000003036601101055_1076241215.0Zinc fingerC2H2-type 8%3B atypical
TgeneZEB2chr2:144314054chr2:145187593ENST00000303660110211_234241215.0Zinc fingerC2H2-type 1
TgeneZEB2chr2:144314054chr2:145187593ENST00000303660110241_263241215.0Zinc fingerC2H2-type 2
TgeneZEB2chr2:144314054chr2:145187593ENST00000303660110282_304241215.0Zinc fingerC2H2-type 3
TgeneZEB2chr2:144314054chr2:145187593ENST00000303660110310_334241215.0Zinc fingerC2H2-type 4%3B atypical
TgeneZEB2chr2:144314054chr2:145187593ENST00000303660110581_605241215.0Zinc fingerC2H2-type 5%3B atypical
TgeneZEB2chr2:144314054chr2:145187593ENST00000303660110999_1021241215.0Zinc fingerC2H2-type 6
TgeneZEB2chr2:144314054chr2:145187593ENST000004094871101027_1049241215.0Zinc fingerC2H2-type 7
TgeneZEB2chr2:144314054chr2:145187593ENST000004094871101055_1076241215.0Zinc fingerC2H2-type 8%3B atypical
TgeneZEB2chr2:144314054chr2:145187593ENST00000409487110211_234241215.0Zinc fingerC2H2-type 1
TgeneZEB2chr2:144314054chr2:145187593ENST00000409487110241_263241215.0Zinc fingerC2H2-type 2
TgeneZEB2chr2:144314054chr2:145187593ENST00000409487110282_304241215.0Zinc fingerC2H2-type 3
TgeneZEB2chr2:144314054chr2:145187593ENST00000409487110310_334241215.0Zinc fingerC2H2-type 4%3B atypical
TgeneZEB2chr2:144314054chr2:145187593ENST00000409487110581_605241215.0Zinc fingerC2H2-type 5%3B atypical
TgeneZEB2chr2:144314054chr2:145187593ENST00000409487110999_1021241215.0Zinc fingerC2H2-type 6
TgeneZEB2chr2:144314054chr2:145187593ENST00000539609191027_1049241191.0Zinc fingerC2H2-type 7
TgeneZEB2chr2:144314054chr2:145187593ENST00000539609191055_1076241191.0Zinc fingerC2H2-type 8%3B atypical
TgeneZEB2chr2:144314054chr2:145187593ENST0000053960919211_234241191.0Zinc fingerC2H2-type 1
TgeneZEB2chr2:144314054chr2:145187593ENST0000053960919241_263241191.0Zinc fingerC2H2-type 2
TgeneZEB2chr2:144314054chr2:145187593ENST0000053960919282_304241191.0Zinc fingerC2H2-type 3
TgeneZEB2chr2:144314054chr2:145187593ENST0000053960919310_334241191.0Zinc fingerC2H2-type 4%3B atypical
TgeneZEB2chr2:144314054chr2:145187593ENST0000053960919581_605241191.0Zinc fingerC2H2-type 5%3B atypical
TgeneZEB2chr2:144314054chr2:145187593ENST0000053960919999_1021241191.0Zinc fingerC2H2-type 6
TgeneZEB2chr2:144314054chr2:145187593ENST000005581701101027_1049241215.0Zinc fingerC2H2-type 7
TgeneZEB2chr2:144314054chr2:145187593ENST000005581701101055_1076241215.0Zinc fingerC2H2-type 8%3B atypical
TgeneZEB2chr2:144314054chr2:145187593ENST00000558170110211_234241215.0Zinc fingerC2H2-type 1
TgeneZEB2chr2:144314054chr2:145187593ENST00000558170110241_263241215.0Zinc fingerC2H2-type 2
TgeneZEB2chr2:144314054chr2:145187593ENST00000558170110282_304241215.0Zinc fingerC2H2-type 3
TgeneZEB2chr2:144314054chr2:145187593ENST00000558170110310_334241215.0Zinc fingerC2H2-type 4%3B atypical
TgeneZEB2chr2:144314054chr2:145187593ENST00000558170110581_605241215.0Zinc fingerC2H2-type 5%3B atypical
TgeneZEB2chr2:144314054chr2:145187593ENST00000558170110999_1021241215.0Zinc fingerC2H2-type 6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP15chr2:144314054chr2:145187593ENST00000295095+1114281_470334476.0DomainRho-GAP


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Fusion Gene Sequence for ARHGAP15-ZEB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5955_5955_1_ARHGAP15-ZEB2_ARHGAP15_chr2_144314054_ENST00000295095_ZEB2_chr2_145187593_ENST00000303660_length(transcript)=6179nt_BP=1170nt
GCCTTTTTCTTCCCCCAGTACTGAAATTAAGCAGCATCCAACACAGGCCTACTCTTACGACATGTGACTTTACTGTTTTCCGTTTTTGTT
GAAAGAGTCATTAACAGTTAGGAGTTGATGGCAGTTTCAATAACAGGTCATTGCCGAGAAAAGGATAGCACTATAATATGCAGAAATCTA
CAAATTCTGATACTTCCGTGGAAACACTGAATTCTACCCGCCAAGGCACAGGAGCTGTGCAAATGAGAATCAAAAATGCCAACAGCCACC
ATGACAGGCTCAGCCAAAGTAAATCCATGATCCTCACCGATGTCGGGAAGGTCACTGAACCTATATCCAGACACAGAAGGAATCATTCAC
AGCATATCTTGAAAGATGTCATTCCTCCATTGGAACAACTGATGGTTGAAAAAGAAGGTTATCTGCAAAAAGCTAAAATTGCAGATGGAG
GAAAGAAACTAAGGAAAAACTGGTCTACTTCCTGGATTGTTCTTTCTAGTCGAAGAATTGAATTTTACAAAGAATCCAAGCAACAGGCTC
TGTCCAATATGAAAACTGGGCACAAACCAGAAAGTGTGGATTTGTGTGGAGCACACATTGAATGGGCCAAGGAAAAATCGAGCAGAAAGA
ATGTCTTTCAGATCACAACAGTATCAGGAAATGAGTTCCTTCTACAGTCAGATATTGACTTCATCATATTGGATTGGTTCCACGCTATCA
AAAATGCAATTGACAGATTGCCAAAGGATTCAAGTTGTCCATCAAGAAACCTGGAATTATTCAAAATCCAAAGATCCTCTAGCACTGAAT
TGCTAAGTCACTACGACAGTGATATAAAAGAACAGAAACCAGAGCACAGAAAATCTTTAATGTTCAGACTGCATCACAGTGCTTCCGATA
CAAGCGACAAAAATCGAGTTAAAAGCAGATTAAAGAAGTTTATTACCCGAAGACCTTCCCTGAAAACTCTGCAAGAAAAAGGACTTATTA
AAGATCAAATTTTTGGCTCTCATCTGCACAAAGTGTGTGAACGTGAAAATTCCACAGTTCCGTGGTTTGTAAAGCAATGCATTGAAGCTG
TTGAGAAAAGAGGTCTAGATGTTGATGGAATATATCGAGTTAGTGGCAATCTGGCAACAATACAGAAGTTAAGATTTATTGTCAACCAAG
TGGTGAACTATGACAATGTAGTGGACACAGGTTCTGAAACAGATGAGGAAGACAAGCTTCATATTGCTGAGGATGACGGTATTGCCAACC
CTCTGGACCAGGAGACGAGTCCAGCTAGTGTGCCCAACCATGAGTCCTCCCCACACGTGAGCCAAGCTCTGTTGCCAAGAGAGGAAGAGG
AAGATGAAATAAGGGAGGGTGGAGTGGAACACCCCTGGCACAACAACGAGATTCTACAAGCCTCTGTAGATGGTCCAGAAGAAATGAAGG
AAGACTATGACACTATGGGGCCAGAAGCCACGATCCAGACCGCAATTAACAATGGTACAGTGAAGAATGCAAATTGCACATCAGATTTTG
AGGAATACTTTGCCAAAAGAAAACTGGAGGAACGCGATGGTCATGCAGTCAGCATCGAGGAGTACCTTCAGCGCAGTGACACAGCCATTA
TTTACCCAGAAGCCCCTGAGGAGCTGTCTCGCCTTGGCACGCCAGAGGCCAATGGGCAAGAAGAAAATGACCTGCCACCTGGAACTCCAG
ATGCTTTTGCCCAACTGCTGACCTGCCCCTACTGCGACCGGGGCTACAAGCGCTTGACATCACTGAAGGAGCACATCAAGTACCGCCACG
AGAAGAATGAAGAGAACTTTTCCTGCCCTCTCTGTAGCTACACGTTTGCCTACCGCACCCAGCTCGAGCGGCATATGGTGACACACAAGC
CAGGGACAGATCAGCACCAAATGCTAACCCAAGGAGCAGGTAATCGCAAGTTCAAATGCACAGAGTGTGGCAAGGCCTTCAAATATAAAC
ACCATCTGAAAGAACACCTGCGAATTCACAGTGGTGAAAAACCTTACGAGTGCCCAAACTGCAAGAAACGTTTCTCCCATTCTGGTTCCT
ACAGTTCGCACATCAGCAGCAAGAAATGTATTGGTTTAATCTCTGTAAATGGCCGAATGAGAAACAATATCAAGACGGGTTCTTCCCCTA
ATTCTGTTTCTTCTTCTCCTACTAATTCAGCCATTACCCAGTTAAGAAACAAGTTGGAGAATGGAAAACCACTTAGTATGTCTGAACAGA
CAGGCTTACTTAAAATTAAAACAGAACCACTAGACTTCAATGACTATAAAGTTCTTATGGCTACACACGGGTTTAGTGGCACTAGTCCCT
TTATGAATGGTGGGCTTGGAGCCACCAGCCCTTTAGGAGTTCATCCATCTGCTCAGAGTCCAATGCAGCACTTAGGTGTAGGGATGGAAG
CCCCTTTACTTGGGTTTCCCACCATGAATAGTAATTTAAGTGAGGTACAAAAGGTTCTACAGATTGTGGACAATACTGTTTCCAGGCAAA
AAATGGACTGCAAGGCTGAAGAAATTTCAAAGTTGAAAGGTTATCACATGAAGGATCCATGCTCTCAACCTGAGGAACAAGGAGTTACTT
CTCCTAATATTCCGCCTGTCGGTCTTCCGGTAGTGAGTCATAATGGTGCCACTAAAAGTATTATTGACTATACGTTGGAAAAAGTCAATG
AAGCCAAAGCTTGCCTCCAGAGCTTGACTACTGACTCAAGGAGACAGATCAGTAATATAAAGAAAGAGAAGCTACGTACTTTAATAGATT
TGGTCACTGATGACAAAATGATTGAGAACCACAACATATCCACTCCATTTTCATGCCAGTTCTGTAAAGAAAGTTTTCCTGGCCCCATCC
CTTTGCATCAGCATGAACGTTACCTTTGTAAGATGAATGAAGAGATCAAGGCGGTCCTGCAGCCTCATGAAAACATAGTCCCCAACAAAG
CCGGAGTTTTTGTTGATAATAAAGCCCTCCTCTTGTCATCTGTACTTTCTGAGAAAGGAATGACAAGCCCCATCAACCCATACAAGGACC
ACATGTCTGTACTCAAAGCATACTATGCTATGAACATGGAGCCCAACTCCGATGAACTGCTGAAAATTTCCATTGCTGTGGGCCTTCCTC
AGGAATTTGTGAAGGAATGGTTTGAACAACGAAAAGTCTACCAGTACTCAAATTCCAGGTCCCCATCCCTGGAAAGAAGCTCCAAGCCGT
TAGCTCCCAACAGTAACCCTCCCACAAAAGACTCTTTATTACCCAGGTCTCCTGTAAAACCTATGGACTCCATAACATCACCATCTATAG
CAGAACTCCACAACAGTGTTACGAATTGTGATCCTCCTCTCAGGCTAACAAAACCTTCCCATTTTACCAATATTAAACCAGTTGAAAAAT
TGGACCACTCCAGGAGTAATACTCCTTCTCCCTTAAATCTTTCCTCCACATCTTCTAAAAACTCCCACAGTAGTTCATACACTCCAAACA
GCTTCTCTTCTGAGGAGCTCCAGGCTGAGCCTTTAGACTTGTCATTACCAAAACAAATGAAAGAACCCAAAAGTATTATAGCCACAAAGA
ACAAAACAAAAGCTAGTAGCATCAGTTTAGATCATAACAGTGTTTCTTCCTCATCTGAAAACTCAGATGAGCCTCTGAACTTGACTTTTA
TCAAGAAGGAATTTTCAAATTCAAATAATCTGGACAACAAAAGCACTAACCCAGTGTTCAGCATGAACCCATTTAGTGCCAAACCTTTAT
ACACAGCTCTTCCACCTCAAAGCGCATTTCCCCCTGCTACTTTCATGCCACCAGTCCAGACCAGTATTCCTGGGCTACGACCATACCCAG
GACTGGATCAGATGAGCTTCCTACCACATATGGCCTACACCTACCCAACTGGAGCAGCTACTTTTGCTGATATGCAGCAAAGGAGAAAGT
ACCAGCGGAAACAAGGATTTCAGGGAGAATTGCTTGATGGAGCACAAGACTACATGTCAGGCCTAGATGATATGACAGACTCCGACTCCT
GTCTGTCTCGCAAAAAGATCAAGAAGACAGAGAGTGGCATGTATGCATGTGACTTATGTGACAAGACATTCCAGAAAAGCAGTTCCCTTC
TGCGACATAAATACGAACACACAGGAAAAAGACCACATCAGTGTCAGATTTGTAAGAAAGCGTTTAAACACAAGCACCACCTTATCGAGC
ACTCAAGGCTTCACTCGGGCGAGAAGCCCTATCAGTGTGATAAATGTGGCAAGCGCTTCTCACACTCGGGCTCGTACTCGCAGCACATGA
ATCACAGGTATTCCTACTGCAAGCGGGAGGCGGAGGAGCGGGAAGCGGCGGAGCGCGAGGCGCGCGAGAAAGGGCACTTGGAACCCACCG
AGCTGCTGATGAACCGGGCTTACTTGCAGAGCATTACCCCTCAGGGGTACTCTGACTCGGAGGAGAGGGAGAGTATGCCGAGGGATGGCG
AGAGCGAGAAGGAGCACGAGAAAGAAGGCGAGGATGGCTACGGGAAGCTGGGCAGACAGGATGGCGACGAGGAGTTCGAGGAGGAAGAGG
AAGAAAGTGAAAATAAAAGTATGGATACGGATCCCGAAACGATACGAGATGAAGAAGAGACTGGAGATCACTCCATGGACGATAGTTCGG
AGGATGGGAAAATGGAAACCAAATCAGACCACGAGGAAGACAATATGGAAGATGGCATGTAATAAACTACTGCATTTTAAGCTTCCTATT
TTTTTTTCCAGTAGTATTGTTACCTGCTTGAAAACACTGCTGTGTTAAGCTGTTCATGCACGTGCCTGACGCTTCCAGGAAGCTGTAGAG
AGGGACAGAAGGGGCGGTTCAGCCAAGACAGATGTAGACGGAGTTGGAGCTGGGTATTGTTAAAAACTGCATTATGCAAAAATTTTGTAC
AGTGTTAAGGCCTAAAAACTGTGTGGTTCAGAGACTAATTCCTGTGTTTAATAGCATTTATACTTTAAGCACAACTAGAAAATTGTAAGA
ATTGCACTCTACTTATGTATCACTACAAACTTTAAAAAACTATGTCTAATTTATATTAATACATTTTAAAAAGGTGCCCGCACTACCATA
CATCAGTATTTTTATTATTATTATTGTTATTCCTTTTTAATTTAATGTGCTCGCACTACAATGCATCAGTATTATGATTCCTCTGTACTT
TCCTTTCGCTATTCATCAATTTCCCATTTTTTTTTTCAGCTTAAGTAACCACACAATTTTAGGCCTCAATTTTTTTTTTTTTCTGTGAAG
GAACTTGAAGTGATGCATGTGTGAATTTAAGATACCGAAGTCTTAAAGTGACCTGGACGTGAAGGAAAAAGTAAGATGAGAAATAAAGAA
AGCCTTTGTAAGGTGGTTTTAAAAGCCTTATATGCAAACCTTTTAATCTGTGTTTCTGCAAGTGCCATCCTTGTACAGTGTTAAGAGGGT
AACATGGGTTACCTTTGCACCAGCTTCAGTGTTAAGCTCACCCTGTTCTTTGAAGCACCCATGTCAGTATTAGAAGAATAGGCAGCAGTT
CCTTAGTTTACATATGTTTGTGCAATTATTTTCTGTACTTTTTTGTTCATTAATTTTGTCAGTATTACACCAAACTGTTTTTGCAACAAA
AAAATTTTTTTTGCATTCATTTAATTTTAGGTCAAATAACATTTTATTTATGTGGCTCATTTTATATTTCCTAATTTTATTTATTTCATA
CTGTAGTGTACAGTATTATAGTTCTTCAATATATAGATATATTTTAGTAAAAAAGGAACATGACGTTGATCATTTGGGCAAATTTTACGT
AAAGAGAAGAGCATTTATTGTGTTTTGGAACATTAATTGTGAGATGGGATTTTTCAATTTTATTATTTTATTTTTGTTTTTTTCCAATTA
CTGGAAATTCCAAATTTGGGAACTTTTGATACGATCTTGTGAAAACACTGTATTTTCGACTGAAAATTCCACTTTCTTCATCTTGTTTTT
TAGCTAAAAAGAGGGACTGTTAAATACAATGTATGATACCATGACAAAAATCTTTCCTGAATTGTCTTTGTAAAAGTATTATTGAATTTT

>5955_5955_1_ARHGAP15-ZEB2_ARHGAP15_chr2_144314054_ENST00000295095_ZEB2_chr2_145187593_ENST00000303660_length(amino acids)=1524AA_BP=334
MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHRRNHSQHILKDVIPPLEQLMVEKEGYLQKAK
IADGGKKLRKNWSTSWIVLSSRRIEFYKESKQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDW
FHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHHSASDTSDKNRVKSRLKKFITRRPSLKTLQE
KGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQVVNYDNVVDTGSETDEEDKLHIAEDD
GIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPEEMKEDYDTMGPEATIQTAINNGTVKNANC
TSDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHI
KYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFS
HSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFS
GTSPFMNGGLGATSPLGVHPSAQSPMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKAEEISKLKGYHMKDPCSQPEE
QGVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHNISTPFSCQFCKESF
PGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNKAGVFVDNKALLLSSVLSEKGMTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIA
VGLPQEFVKEWFEQRKVYQYSNSRSPSLERSSKPLAPNSNPPTKDSLLPRSPVKPMDSITSPSIAELHNSVTNCDPPLRLTKPSHFTNIK
PVEKLDHSRSNTPSPLNLSSTSSKNSHSSSYTPNSFSSEELQAEPLDLSLPKQMKEPKSIIATKNKTKASSISLDHNSVSSSSENSDEPL
NLTFIKKEFSNSNNLDNKSTNPVFSMNPFSAKPLYTALPPQSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQ
QRRKYQRKQGFQGELLDGAQDYMSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAFKHKH
HLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEEREAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESM

--------------------------------------------------------------
>5955_5955_2_ARHGAP15-ZEB2_ARHGAP15_chr2_144314054_ENST00000295095_ZEB2_chr2_145187593_ENST00000409487_length(transcript)=6192nt_BP=1170nt
GCCTTTTTCTTCCCCCAGTACTGAAATTAAGCAGCATCCAACACAGGCCTACTCTTACGACATGTGACTTTACTGTTTTCCGTTTTTGTT
GAAAGAGTCATTAACAGTTAGGAGTTGATGGCAGTTTCAATAACAGGTCATTGCCGAGAAAAGGATAGCACTATAATATGCAGAAATCTA
CAAATTCTGATACTTCCGTGGAAACACTGAATTCTACCCGCCAAGGCACAGGAGCTGTGCAAATGAGAATCAAAAATGCCAACAGCCACC
ATGACAGGCTCAGCCAAAGTAAATCCATGATCCTCACCGATGTCGGGAAGGTCACTGAACCTATATCCAGACACAGAAGGAATCATTCAC
AGCATATCTTGAAAGATGTCATTCCTCCATTGGAACAACTGATGGTTGAAAAAGAAGGTTATCTGCAAAAAGCTAAAATTGCAGATGGAG
GAAAGAAACTAAGGAAAAACTGGTCTACTTCCTGGATTGTTCTTTCTAGTCGAAGAATTGAATTTTACAAAGAATCCAAGCAACAGGCTC
TGTCCAATATGAAAACTGGGCACAAACCAGAAAGTGTGGATTTGTGTGGAGCACACATTGAATGGGCCAAGGAAAAATCGAGCAGAAAGA
ATGTCTTTCAGATCACAACAGTATCAGGAAATGAGTTCCTTCTACAGTCAGATATTGACTTCATCATATTGGATTGGTTCCACGCTATCA
AAAATGCAATTGACAGATTGCCAAAGGATTCAAGTTGTCCATCAAGAAACCTGGAATTATTCAAAATCCAAAGATCCTCTAGCACTGAAT
TGCTAAGTCACTACGACAGTGATATAAAAGAACAGAAACCAGAGCACAGAAAATCTTTAATGTTCAGACTGCATCACAGTGCTTCCGATA
CAAGCGACAAAAATCGAGTTAAAAGCAGATTAAAGAAGTTTATTACCCGAAGACCTTCCCTGAAAACTCTGCAAGAAAAAGGACTTATTA
AAGATCAAATTTTTGGCTCTCATCTGCACAAAGTGTGTGAACGTGAAAATTCCACAGTTCCGTGGTTTGTAAAGCAATGCATTGAAGCTG
TTGAGAAAAGAGGTCTAGATGTTGATGGAATATATCGAGTTAGTGGCAATCTGGCAACAATACAGAAGTTAAGATTTATTGTCAACCAAG
TGGTGAACTATGACAATGTAGTGGACACAGGTTCTGAAACAGATGAGGAAGACAAGCTTCATATTGCTGAGGATGACGGTATTGCCAACC
CTCTGGACCAGGAGACGAGTCCAGCTAGTGTGCCCAACCATGAGTCCTCCCCACACGTGAGCCAAGCTCTGTTGCCAAGAGAGGAAGAGG
AAGATGAAATAAGGGAGGGTGGAGTGGAACACCCCTGGCACAACAACGAGATTCTACAAGCCTCTGTAGATGGTCCAGAAGAAATGAAGG
AAGACTATGACACTATGGGGCCAGAAGCCACGATCCAGACCGCAATTAACAATGGTACAGTGAAGAATGCAAATTGCACATCAGATTTTG
AGGAATACTTTGCCAAAAGAAAACTGGAGGAACGCGATGGTCATGCAGTCAGCATCGAGGAGTACCTTCAGCGCAGTGACACAGCCATTA
TTTACCCAGAAGCCCCTGAGGAGCTGTCTCGCCTTGGCACGCCAGAGGCCAATGGGCAAGAAGAAAATGACCTGCCACCTGGAACTCCAG
ATGCTTTTGCCCAACTGCTGACCTGCCCCTACTGCGACCGGGGCTACAAGCGCTTGACATCACTGAAGGAGCACATCAAGTACCGCCACG
AGAAGAATGAAGAGAACTTTTCCTGCCCTCTCTGTAGCTACACGTTTGCCTACCGCACCCAGCTCGAGCGGCATATGGTGACACACAAGC
CAGGGACAGATCAGCACCAAATGCTAACCCAAGGAGCAGGTAATCGCAAGTTCAAATGCACAGAGTGTGGCAAGGCCTTCAAATATAAAC
ACCATCTGAAAGAACACCTGCGAATTCACAGTGGTGAAAAACCTTACGAGTGCCCAAACTGCAAGAAACGTTTCTCCCATTCTGGTTCCT
ACAGTTCGCACATCAGCAGCAAGAAATGTATTGGTTTAATCTCTGTAAATGGCCGAATGAGAAACAATATCAAGACGGGTTCTTCCCCTA
ATTCTGTTTCTTCTTCTCCTACTAATTCAGCCATTACCCAGTTAAGAAACAAGTTGGAGAATGGAAAACCACTTAGTATGTCTGAACAGA
CAGGCTTACTTAAAATTAAAACAGAACCACTAGACTTCAATGACTATAAAGTTCTTATGGCTACACACGGGTTTAGTGGCACTAGTCCCT
TTATGAATGGTGGGCTTGGAGCCACCAGCCCTTTAGGAGTTCATCCATCTGCTCAGAGTCCAATGCAGCACTTAGGTGTAGGGATGGAAG
CCCCTTTACTTGGGTTTCCCACCATGAATAGTAATTTAAGTGAGGTACAAAAGGTTCTACAGATTGTGGACAATACTGTTTCCAGGCAAA
AAATGGACTGCAAGGCTGAAGAAATTTCAAAGTTGAAAGGTTATCACATGAAGGATCCATGCTCTCAACCTGAGGAACAAGGAGTTACTT
CTCCTAATATTCCGCCTGTCGGTCTTCCGGTAGTGAGTCATAATGGTGCCACTAAAAGTATTATTGACTATACGTTGGAAAAAGTCAATG
AAGCCAAAGCTTGCCTCCAGAGCTTGACTACTGACTCAAGGAGACAGATCAGTAATATAAAGAAAGAGAAGCTACGTACTTTAATAGATT
TGGTCACTGATGACAAAATGATTGAGAACCACAACATATCCACTCCATTTTCATGCCAGTTCTGTAAAGAAAGTTTTCCTGGCCCCATCC
CTTTGCATCAGCATGAACGTTACCTTTGTAAGATGAATGAAGAGATCAAGGCGGTCCTGCAGCCTCATGAAAACATAGTCCCCAACAAAG
CCGGAGTTTTTGTTGATAATAAAGCCCTCCTCTTGTCATCTGTACTTTCTGAGAAAGGAATGACAAGCCCCATCAACCCATACAAGGACC
ACATGTCTGTACTCAAAGCATACTATGCTATGAACATGGAGCCCAACTCCGATGAACTGCTGAAAATTTCCATTGCTGTGGGCCTTCCTC
AGGAATTTGTGAAGGAATGGTTTGAACAACGAAAAGTCTACCAGTACTCAAATTCCAGGTCCCCATCCCTGGAAAGAAGCTCCAAGCCGT
TAGCTCCCAACAGTAACCCTCCCACAAAAGACTCTTTATTACCCAGGTCTCCTGTAAAACCTATGGACTCCATAACATCACCATCTATAG
CAGAACTCCACAACAGTGTTACGAATTGTGATCCTCCTCTCAGGCTAACAAAACCTTCCCATTTTACCAATATTAAACCAGTTGAAAAAT
TGGACCACTCCAGGAGTAATACTCCTTCTCCCTTAAATCTTTCCTCCACATCTTCTAAAAACTCCCACAGTAGTTCATACACTCCAAACA
GCTTCTCTTCTGAGGAGCTCCAGGCTGAGCCTTTAGACTTGTCATTACCAAAACAAATGAAAGAACCCAAAAGTATTATAGCCACAAAGA
ACAAAACAAAAGCTAGTAGCATCAGTTTAGATCATAACAGTGTTTCTTCCTCATCTGAAAACTCAGATGAGCCTCTGAACTTGACTTTTA
TCAAGAAGGAATTTTCAAATTCAAATAATCTGGACAACAAAAGCACTAACCCAGTGTTCAGCATGAACCCATTTAGTGCCAAACCTTTAT
ACACAGCTCTTCCACCTCAAAGCGCATTTCCCCCTGCTACTTTCATGCCACCAGTCCAGACCAGTATTCCTGGGCTACGACCATACCCAG
GACTGGATCAGATGAGCTTCCTACCACATATGGCCTACACCTACCCAACTGGAGCAGCTACTTTTGCTGATATGCAGCAAAGGAGAAAGT
ACCAGCGGAAACAAGGATTTCAGGGAGAATTGCTTGATGGAGCACAAGACTACATGTCAGGCCTAGATGATATGACAGACTCCGACTCCT
GTCTGTCTCGCAAAAAGATCAAGAAGACAGAGAGTGGCATGTATGCATGTGACTTATGTGACAAGACATTCCAGAAAAGCAGTTCCCTTC
TGCGACATAAATACGAACACACAGGAAAAAGACCACATCAGTGTCAGATTTGTAAGAAAGCGTTTAAACACAAGCACCACCTTATCGAGC
ACTCAAGGCTTCACTCGGGCGAGAAGCCCTATCAGTGTGATAAATGTGGCAAGCGCTTCTCACACTCGGGCTCGTACTCGCAGCACATGA
ATCACAGGTATTCCTACTGCAAGCGGGAGGCGGAGGAGCGGGAAGCGGCGGAGCGCGAGGCGCGCGAGAAAGGGCACTTGGAACCCACCG
AGCTGCTGATGAACCGGGCTTACTTGCAGAGCATTACCCCTCAGGGGTACTCTGACTCGGAGGAGAGGGAGAGTATGCCGAGGGATGGCG
AGAGCGAGAAGGAGCACGAGAAAGAAGGCGAGGATGGCTACGGGAAGCTGGGCAGACAGGATGGCGACGAGGAGTTCGAGGAGGAAGAGG
AAGAAAGTGAAAATAAAAGTATGGATACGGATCCCGAAACGATACGAGATGAAGAAGAGACTGGAGATCACTCCATGGACGATAGTTCGG
AGGATGGGAAAATGGAAACCAAATCAGACCACGAGGAAGACAATATGGAAGATGGCATGTAATAAACTACTGCATTTTAAGCTTCCTATT
TTTTTTTCCAGTAGTATTGTTACCTGCTTGAAAACACTGCTGTGTTAAGCTGTTCATGCACGTGCCTGACGCTTCCAGGAAGCTGTAGAG
AGGGACAGAAGGGGCGGTTCAGCCAAGACAGATGTAGACGGAGTTGGAGCTGGGTATTGTTAAAAACTGCATTATGCAAAAATTTTGTAC
AGTGTTAAGGCCTAAAAACTGTGTGGTTCAGAGACTAATTCCTGTGTTTAATAGCATTTATACTTTAAGCACAACTAGAAAATTGTAAGA
ATTGCACTCTACTTATGTATCACTACAAACTTTAAAAAACTATGTCTAATTTATATTAATACATTTTAAAAAGGTGCCCGCACTACCATA
CATCAGTATTTTTATTATTATTATTGTTATTCCTTTTTAATTTAATGTGCTCGCACTACAATGCATCAGTATTATGATTCCTCTGTACTT
TCCTTTCGCTATTCATCAATTTCCCATTTTTTTTTTCAGCTTAAGTAACCACACAATTTTAGGCCTCAATTTTTTTTTTTTTCTGTGAAG
GAACTTGAAGTGATGCATGTGTGAATTTAAGATACCGAAGTCTTAAAGTGACCTGGACGTGAAGGAAAAAGTAAGATGAGAAATAAAGAA
AGCCTTTGTAAGGTGGTTTTAAAAGCCTTATATGCAAACCTTTTAATCTGTGTTTCTGCAAGTGCCATCCTTGTACAGTGTTAAGAGGGT
AACATGGGTTACCTTTGCACCAGCTTCAGTGTTAAGCTCACCCTGTTCTTTGAAGCACCCATGTCAGTATTAGAAGAATAGGCAGCAGTT
CCTTAGTTTACATATGTTTGTGCAATTATTTTCTGTACTTTTTTGTTCATTAATTTTGTCAGTATTACACCAAACTGTTTTTGCAACAAA
AAAATTTTTTTTGCATTCATTTAATTTTAGGTCAAATAACATTTTATTTATGTGGCTCATTTTATATTTCCTAATTTTATTTATTTCATA
CTGTAGTGTACAGTATTATAGTTCTTCAATATATAGATATATTTTAGTAAAAAAGGAACATGACGTTGATCATTTGGGCAAATTTTACGT
AAAGAGAAGAGCATTTATTGTGTTTTGGAACATTAATTGTGAGATGGGATTTTTCAATTTTATTATTTTATTTTTGTTTTTTTCCAATTA
CTGGAAATTCCAAATTTGGGAACTTTTGATACGATCTTGTGAAAACACTGTATTTTCGACTGAAAATTCCACTTTCTTCATCTTGTTTTT
TAGCTAAAAAGAGGGACTGTTAAATACAATGTATGATACCATGACAAAAATCTTTCCTGAATTGTCTTTGTAAAAGTATTATTGAATTTT

>5955_5955_2_ARHGAP15-ZEB2_ARHGAP15_chr2_144314054_ENST00000295095_ZEB2_chr2_145187593_ENST00000409487_length(amino acids)=1524AA_BP=334
MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHRRNHSQHILKDVIPPLEQLMVEKEGYLQKAK
IADGGKKLRKNWSTSWIVLSSRRIEFYKESKQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDW
FHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHHSASDTSDKNRVKSRLKKFITRRPSLKTLQE
KGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQVVNYDNVVDTGSETDEEDKLHIAEDD
GIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPEEMKEDYDTMGPEATIQTAINNGTVKNANC
TSDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHI
KYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFS
HSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFS
GTSPFMNGGLGATSPLGVHPSAQSPMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKAEEISKLKGYHMKDPCSQPEE
QGVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHNISTPFSCQFCKESF
PGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNKAGVFVDNKALLLSSVLSEKGMTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIA
VGLPQEFVKEWFEQRKVYQYSNSRSPSLERSSKPLAPNSNPPTKDSLLPRSPVKPMDSITSPSIAELHNSVTNCDPPLRLTKPSHFTNIK
PVEKLDHSRSNTPSPLNLSSTSSKNSHSSSYTPNSFSSEELQAEPLDLSLPKQMKEPKSIIATKNKTKASSISLDHNSVSSSSENSDEPL
NLTFIKKEFSNSNNLDNKSTNPVFSMNPFSAKPLYTALPPQSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQ
QRRKYQRKQGFQGELLDGAQDYMSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAFKHKH
HLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEEREAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESM

--------------------------------------------------------------
>5955_5955_3_ARHGAP15-ZEB2_ARHGAP15_chr2_144314054_ENST00000295095_ZEB2_chr2_145187593_ENST00000539609_length(transcript)=6104nt_BP=1170nt
GCCTTTTTCTTCCCCCAGTACTGAAATTAAGCAGCATCCAACACAGGCCTACTCTTACGACATGTGACTTTACTGTTTTCCGTTTTTGTT
GAAAGAGTCATTAACAGTTAGGAGTTGATGGCAGTTTCAATAACAGGTCATTGCCGAGAAAAGGATAGCACTATAATATGCAGAAATCTA
CAAATTCTGATACTTCCGTGGAAACACTGAATTCTACCCGCCAAGGCACAGGAGCTGTGCAAATGAGAATCAAAAATGCCAACAGCCACC
ATGACAGGCTCAGCCAAAGTAAATCCATGATCCTCACCGATGTCGGGAAGGTCACTGAACCTATATCCAGACACAGAAGGAATCATTCAC
AGCATATCTTGAAAGATGTCATTCCTCCATTGGAACAACTGATGGTTGAAAAAGAAGGTTATCTGCAAAAAGCTAAAATTGCAGATGGAG
GAAAGAAACTAAGGAAAAACTGGTCTACTTCCTGGATTGTTCTTTCTAGTCGAAGAATTGAATTTTACAAAGAATCCAAGCAACAGGCTC
TGTCCAATATGAAAACTGGGCACAAACCAGAAAGTGTGGATTTGTGTGGAGCACACATTGAATGGGCCAAGGAAAAATCGAGCAGAAAGA
ATGTCTTTCAGATCACAACAGTATCAGGAAATGAGTTCCTTCTACAGTCAGATATTGACTTCATCATATTGGATTGGTTCCACGCTATCA
AAAATGCAATTGACAGATTGCCAAAGGATTCAAGTTGTCCATCAAGAAACCTGGAATTATTCAAAATCCAAAGATCCTCTAGCACTGAAT
TGCTAAGTCACTACGACAGTGATATAAAAGAACAGAAACCAGAGCACAGAAAATCTTTAATGTTCAGACTGCATCACAGTGCTTCCGATA
CAAGCGACAAAAATCGAGTTAAAAGCAGATTAAAGAAGTTTATTACCCGAAGACCTTCCCTGAAAACTCTGCAAGAAAAAGGACTTATTA
AAGATCAAATTTTTGGCTCTCATCTGCACAAAGTGTGTGAACGTGAAAATTCCACAGTTCCGTGGTTTGTAAAGCAATGCATTGAAGCTG
TTGAGAAAAGAGGTCTAGATGTTGATGGAATATATCGAGTTAGTGGCAATCTGGCAACAATACAGAAGTTAAGATTTATTGTCAACCAAG
TGGTGAACTATGACAATGTAGTGGACACAGGTTCTGAAACAGATGAGGAAGACAAGCTTCATATTGCTGAGGATGACGGTATTGCCAACC
CTCTGGACCAGGAGACGAGTCCAGCTAGTGTGCCCAACCATGAGTCCTCCCCACACGTGAGCCAAGCTCTGTTGCCAAGAGAGGAAGAGG
AAGATGAAATAAGGGAGGGTGGAGTGGAACACCCCTGGCACAACAACGAGATTCTACAAGCCTCTGTAGATGGTCCAGTGAAGAATGCAA
ATTGCACATCAGATTTTGAGGAATACTTTGCCAAAAGAAAACTGGAGGAACGCGATGGTCATGCAGTCAGCATCGAGGAGTACCTTCAGC
GCAGTGACACAGCCATTATTTACCCAGAAGCCCCTGAGGAGCTGTCTCGCCTTGGCACGCCAGAGGCCAATGGGCAAGAAGAAAATGACC
TGCCACCTGGAACTCCAGATGCTTTTGCCCAACTGCTGACCTGCCCCTACTGCGACCGGGGCTACAAGCGCTTGACATCACTGAAGGAGC
ACATCAAGTACCGCCACGAGAAGAATGAAGAGAACTTTTCCTGCCCTCTCTGTAGCTACACGTTTGCCTACCGCACCCAGCTCGAGCGGC
ATATGGTGACACACAAGCCAGGGACAGATCAGCACCAAATGCTAACCCAAGGAGCAGGTAATCGCAAGTTCAAATGCACAGAGTGTGGCA
AGGCCTTCAAATATAAACACCATCTGAAAGAACACCTGCGAATTCACAGTGGTGAAAAACCTTACGAGTGCCCAAACTGCAAGAAACGTT
TCTCCCATTCTGGTTCCTACAGTTCGCACATCAGCAGCAAGAAATGTATTGGTTTAATCTCTGTAAATGGCCGAATGAGAAACAATATCA
AGACGGGTTCTTCCCCTAATTCTGTTTCTTCTTCTCCTACTAATTCAGCCATTACCCAGTTAAGAAACAAGTTGGAGAATGGAAAACCAC
TTAGTATGTCTGAACAGACAGGCTTACTTAAAATTAAAACAGAACCACTAGACTTCAATGACTATAAAGTTCTTATGGCTACACACGGGT
TTAGTGGCACTAGTCCCTTTATGAATGGTGGGCTTGGAGCCACCAGCCCTTTAGGAGTTCATCCATCTGCTCAGAGTCCAATGCAGCACT
TAGGTGTAGGGATGGAAGCCCCTTTACTTGGGTTTCCCACCATGAATAGTAATTTAAGTGAGGTACAAAAGGTTCTACAGATTGTGGACA
ATACTGTTTCCAGGCAAAAAATGGACTGCAAGGCTGAAGAAATTTCAAAGTTGAAAGGTTATCACATGAAGGATCCATGCTCTCAACCTG
AGGAACAAGGAGTTACTTCTCCTAATATTCCGCCTGTCGGTCTTCCGGTAGTGAGTCATAATGGTGCCACTAAAAGTATTATTGACTATA
CGTTGGAAAAAGTCAATGAAGCCAAAGCTTGCCTCCAGAGCTTGACTACTGACTCAAGGAGACAGATCAGTAATATAAAGAAAGAGAAGC
TACGTACTTTAATAGATTTGGTCACTGATGACAAAATGATTGAGAACCACAACATATCCACTCCATTTTCATGCCAGTTCTGTAAAGAAA
GTTTTCCTGGCCCCATCCCTTTGCATCAGCATGAACGTTACCTTTGTAAGATGAATGAAGAGATCAAGGCGGTCCTGCAGCCTCATGAAA
ACATAGTCCCCAACAAAGCCGGAGTTTTTGTTGATAATAAAGCCCTCCTCTTGTCATCTGTACTTTCTGAGAAAGGAATGACAAGCCCCA
TCAACCCATACAAGGACCACATGTCTGTACTCAAAGCATACTATGCTATGAACATGGAGCCCAACTCCGATGAACTGCTGAAAATTTCCA
TTGCTGTGGGCCTTCCTCAGGAATTTGTGAAGGAATGGTTTGAACAACGAAAAGTCTACCAGTACTCAAATTCCAGGTCCCCATCCCTGG
AAAGAAGCTCCAAGCCGTTAGCTCCCAACAGTAACCCTCCCACAAAAGACTCTTTATTACCCAGGTCTCCTGTAAAACCTATGGACTCCA
TAACATCACCATCTATAGCAGAACTCCACAACAGTGTTACGAATTGTGATCCTCCTCTCAGGCTAACAAAACCTTCCCATTTTACCAATA
TTAAACCAGTTGAAAAATTGGACCACTCCAGGAGTAATACTCCTTCTCCCTTAAATCTTTCCTCCACATCTTCTAAAAACTCCCACAGTA
GTTCATACACTCCAAACAGCTTCTCTTCTGAGGAGCTCCAGGCTGAGCCTTTAGACTTGTCATTACCAAAACAAATGAAAGAACCCAAAA
GTATTATAGCCACAAAGAACAAAACAAAAGCTAGTAGCATCAGTTTAGATCATAACAGTGTTTCTTCCTCATCTGAAAACTCAGATGAGC
CTCTGAACTTGACTTTTATCAAGAAGGAATTTTCAAATTCAAATAATCTGGACAACAAAAGCACTAACCCAGTGTTCAGCATGAACCCAT
TTAGTGCCAAACCTTTATACACAGCTCTTCCACCTCAAAGCGCATTTCCCCCTGCTACTTTCATGCCACCAGTCCAGACCAGTATTCCTG
GGCTACGACCATACCCAGGACTGGATCAGATGAGCTTCCTACCACATATGGCCTACACCTACCCAACTGGAGCAGCTACTTTTGCTGATA
TGCAGCAAAGGAGAAAGTACCAGCGGAAACAAGGATTTCAGGGAGAATTGCTTGATGGAGCACAAGACTACATGTCAGGCCTAGATGATA
TGACAGACTCCGACTCCTGTCTGTCTCGCAAAAAGATCAAGAAGACAGAGAGTGGCATGTATGCATGTGACTTATGTGACAAGACATTCC
AGAAAAGCAGTTCCCTTCTGCGACATAAATACGAACACACAGGAAAAAGACCACATCAGTGTCAGATTTGTAAGAAAGCGTTTAAACACA
AGCACCACCTTATCGAGCACTCAAGGCTTCACTCGGGCGAGAAGCCCTATCAGTGTGATAAATGTGGCAAGCGCTTCTCACACTCGGGCT
CGTACTCGCAGCACATGAATCACAGGTATTCCTACTGCAAGCGGGAGGCGGAGGAGCGGGAAGCGGCGGAGCGCGAGGCGCGCGAGAAAG
GGCACTTGGAACCCACCGAGCTGCTGATGAACCGGGCTTACTTGCAGAGCATTACCCCTCAGGGGTACTCTGACTCGGAGGAGAGGGAGA
GTATGCCGAGGGATGGCGAGAGCGAGAAGGAGCACGAGAAAGAAGGCGAGGATGGCTACGGGAAGCTGGGCAGACAGGATGGCGACGAGG
AGTTCGAGGAGGAAGAGGAAGAAAGTGAAAATAAAAGTATGGATACGGATCCCGAAACGATACGAGATGAAGAAGAGACTGGAGATCACT
CCATGGACGATAGTTCGGAGGATGGGAAAATGGAAACCAAATCAGACCACGAGGAAGACAATATGGAAGATGGCATGTAATAAACTACTG
CATTTTAAGCTTCCTATTTTTTTTTCCAGTAGTATTGTTACCTGCTTGAAAACACTGCTGTGTTAAGCTGTTCATGCACGTGCCTGACGC
TTCCAGGAAGCTGTAGAGAGGGACAGAAGGGGCGGTTCAGCCAAGACAGATGTAGACGGAGTTGGAGCTGGGTATTGTTAAAAACTGCAT
TATGCAAAAATTTTGTACAGTGTTAAGGCCTAAAAACTGTGTGGTTCAGAGACTAATTCCTGTGTTTAATAGCATTTATACTTTAAGCAC
AACTAGAAAATTGTAAGAATTGCACTCTACTTATGTATCACTACAAACTTTAAAAAACTATGTCTAATTTATATTAATACATTTTAAAAA
GGTGCCCGCACTACCATACATCAGTATTTTTATTATTATTATTGTTATTCCTTTTTAATTTAATGTGCTCGCACTACAATGCATCAGTAT
TATGATTCCTCTGTACTTTCCTTTCGCTATTCATCAATTTCCCATTTTTTTTTTCAGCTTAAGTAACCACACAATTTTAGGCCTCAATTT
TTTTTTTTTTCTGTGAAGGAACTTGAAGTGATGCATGTGTGAATTTAAGATACCGAAGTCTTAAAGTGACCTGGACGTGAAGGAAAAAGT
AAGATGAGAAATAAAGAAAGCCTTTGTAAGGTGGTTTTAAAAGCCTTATATGCAAACCTTTTAATCTGTGTTTCTGCAAGTGCCATCCTT
GTACAGTGTTAAGAGGGTAACATGGGTTACCTTTGCACCAGCTTCAGTGTTAAGCTCACCCTGTTCTTTGAAGCACCCATGTCAGTATTA
GAAGAATAGGCAGCAGTTCCTTAGTTTACATATGTTTGTGCAATTATTTTCTGTACTTTTTTGTTCATTAATTTTGTCAGTATTACACCA
AACTGTTTTTGCAACAAAAAAATTTTTTTTGCATTCATTTAATTTTAGGTCAAATAACATTTTATTTATGTGGCTCATTTTATATTTCCT
AATTTTATTTATTTCATACTGTAGTGTACAGTATTATAGTTCTTCAATATATAGATATATTTTAGTAAAAAAGGAACATGACGTTGATCA
TTTGGGCAAATTTTACGTAAAGAGAAGAGCATTTATTGTGTTTTGGAACATTAATTGTGAGATGGGATTTTTCAATTTTATTATTTTATT
TTTGTTTTTTTCCAATTACTGGAAATTCCAAATTTGGGAACTTTTGATACGATCTTGTGAAAACACTGTATTTTCGACTGAAAATTCCAC
TTTCTTCATCTTGTTTTTTAGCTAAAAAGAGGGACTGTTAAATACAATGTATGATACCATGACAAAAATCTTTCCTGAATTGTCTTTGTA

>5955_5955_3_ARHGAP15-ZEB2_ARHGAP15_chr2_144314054_ENST00000295095_ZEB2_chr2_145187593_ENST00000539609_length(amino acids)=1500AA_BP=334
MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHRRNHSQHILKDVIPPLEQLMVEKEGYLQKAK
IADGGKKLRKNWSTSWIVLSSRRIEFYKESKQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDW
FHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHHSASDTSDKNRVKSRLKKFITRRPSLKTLQE
KGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQVVNYDNVVDTGSETDEEDKLHIAEDD
GIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPVKNANCTSDFEEYFAKRKLEERDGHAVSIE
EYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEKNEENFSCPLCSYTFAYRT
QLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCIGLISVNGRM
RNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFSGTSPFMNGGLGATSPLGVHPSAQS
PMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKAEEISKLKGYHMKDPCSQPEEQGVTSPNIPPVGLPVVSHNGATKS
IIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHNISTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKAVL
QPHENIVPNKAGVFVDNKALLLSSVLSEKGMTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQYSNSR
SPSLERSSKPLAPNSNPPTKDSLLPRSPVKPMDSITSPSIAELHNSVTNCDPPLRLTKPSHFTNIKPVEKLDHSRSNTPSPLNLSSTSSK
NSHSSSYTPNSFSSEELQAEPLDLSLPKQMKEPKSIIATKNKTKASSISLDHNSVSSSSENSDEPLNLTFIKKEFSNSNNLDNKSTNPVF
SMNPFSAKPLYTALPPQSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQGELLDGAQDYMS
GLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRF
SHSGSYSQHMNHRYSYCKREAEEREAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESMPRDGESEKEHEKEGEDGYGKLGRQ

--------------------------------------------------------------
>5955_5955_4_ARHGAP15-ZEB2_ARHGAP15_chr2_144314054_ENST00000295095_ZEB2_chr2_145187593_ENST00000558170_length(transcript)=10112nt_BP=1170nt
GCCTTTTTCTTCCCCCAGTACTGAAATTAAGCAGCATCCAACACAGGCCTACTCTTACGACATGTGACTTTACTGTTTTCCGTTTTTGTT
GAAAGAGTCATTAACAGTTAGGAGTTGATGGCAGTTTCAATAACAGGTCATTGCCGAGAAAAGGATAGCACTATAATATGCAGAAATCTA
CAAATTCTGATACTTCCGTGGAAACACTGAATTCTACCCGCCAAGGCACAGGAGCTGTGCAAATGAGAATCAAAAATGCCAACAGCCACC
ATGACAGGCTCAGCCAAAGTAAATCCATGATCCTCACCGATGTCGGGAAGGTCACTGAACCTATATCCAGACACAGAAGGAATCATTCAC
AGCATATCTTGAAAGATGTCATTCCTCCATTGGAACAACTGATGGTTGAAAAAGAAGGTTATCTGCAAAAAGCTAAAATTGCAGATGGAG
GAAAGAAACTAAGGAAAAACTGGTCTACTTCCTGGATTGTTCTTTCTAGTCGAAGAATTGAATTTTACAAAGAATCCAAGCAACAGGCTC
TGTCCAATATGAAAACTGGGCACAAACCAGAAAGTGTGGATTTGTGTGGAGCACACATTGAATGGGCCAAGGAAAAATCGAGCAGAAAGA
ATGTCTTTCAGATCACAACAGTATCAGGAAATGAGTTCCTTCTACAGTCAGATATTGACTTCATCATATTGGATTGGTTCCACGCTATCA
AAAATGCAATTGACAGATTGCCAAAGGATTCAAGTTGTCCATCAAGAAACCTGGAATTATTCAAAATCCAAAGATCCTCTAGCACTGAAT
TGCTAAGTCACTACGACAGTGATATAAAAGAACAGAAACCAGAGCACAGAAAATCTTTAATGTTCAGACTGCATCACAGTGCTTCCGATA
CAAGCGACAAAAATCGAGTTAAAAGCAGATTAAAGAAGTTTATTACCCGAAGACCTTCCCTGAAAACTCTGCAAGAAAAAGGACTTATTA
AAGATCAAATTTTTGGCTCTCATCTGCACAAAGTGTGTGAACGTGAAAATTCCACAGTTCCGTGGTTTGTAAAGCAATGCATTGAAGCTG
TTGAGAAAAGAGGTCTAGATGTTGATGGAATATATCGAGTTAGTGGCAATCTGGCAACAATACAGAAGTTAAGATTTATTGTCAACCAAG
TGGTGAACTATGACAATGTAGTGGACACAGGTTCTGAAACAGATGAGGAAGACAAGCTTCATATTGCTGAGGATGACGGTATTGCCAACC
CTCTGGACCAGGAGACGAGTCCAGCTAGTGTGCCCAACCATGAGTCCTCCCCACACGTGAGCCAAGCTCTGTTGCCAAGAGAGGAAGAGG
AAGATGAAATAAGGGAGGGTGGAGTGGAACACCCCTGGCACAACAACGAGATTCTACAAGCCTCTGTAGATGGTCCAGAAGAAATGAAGG
AAGACTATGACACTATGGGGCCAGAAGCCACGATCCAGACCGCAATTAACAATGGTACAGTGAAGAATGCAAATTGCACATCAGATTTTG
AGGAATACTTTGCCAAAAGAAAACTGGAGGAACGCGATGGTCATGCAGTCAGCATCGAGGAGTACCTTCAGCGCAGTGACACAGCCATTA
TTTACCCAGAAGCCCCTGAGGAGCTGTCTCGCCTTGGCACGCCAGAGGCCAATGGGCAAGAAGAAAATGACCTGCCACCTGGAACTCCAG
ATGCTTTTGCCCAACTGCTGACCTGCCCCTACTGCGACCGGGGCTACAAGCGCTTGACATCACTGAAGGAGCACATCAAGTACCGCCACG
AGAAGAATGAAGAGAACTTTTCCTGCCCTCTCTGTAGCTACACGTTTGCCTACCGCACCCAGCTCGAGCGGCATATGGTGACACACAAGC
CAGGGACAGATCAGCACCAAATGCTAACCCAAGGAGCAGGTAATCGCAAGTTCAAATGCACAGAGTGTGGCAAGGCCTTCAAATATAAAC
ACCATCTGAAAGAACACCTGCGAATTCACAGTGGTGAAAAACCTTACGAGTGCCCAAACTGCAAGAAACGTTTCTCCCATTCTGGTTCCT
ACAGTTCGCACATCAGCAGCAAGAAATGTATTGGTTTAATCTCTGTAAATGGCCGAATGAGAAACAATATCAAGACGGGTTCTTCCCCTA
ATTCTGTTTCTTCTTCTCCTACTAATTCAGCCATTACCCAGTTAAGAAACAAGTTGGAGAATGGAAAACCACTTAGTATGTCTGAACAGA
CAGGCTTACTTAAAATTAAAACAGAACCACTAGACTTCAATGACTATAAAGTTCTTATGGCTACACACGGGTTTAGTGGCACTAGTCCCT
TTATGAATGGTGGGCTTGGAGCCACCAGCCCTTTAGGAGTTCATCCATCTGCTCAGAGTCCAATGCAGCACTTAGGTGTAGGGATGGAAG
CCCCTTTACTTGGGTTTCCCACCATGAATAGTAATTTAAGTGAGGTACAAAAGGTTCTACAGATTGTGGACAATACTGTTTCCAGGCAAA
AAATGGACTGCAAGGCTGAAGAAATTTCAAAGTTGAAAGGTTATCACATGAAGGATCCATGCTCTCAACCTGAGGAACAAGGAGTTACTT
CTCCTAATATTCCGCCTGTCGGTCTTCCGGTAGTGAGTCATAATGGTGCCACTAAAAGTATTATTGACTATACGTTGGAAAAAGTCAATG
AAGCCAAAGCTTGCCTCCAGAGCTTGACTACTGACTCAAGGAGACAGATCAGTAATATAAAGAAAGAGAAGCTACGTACTTTAATAGATT
TGGTCACTGATGACAAAATGATTGAGAACCACAACATATCCACTCCATTTTCATGCCAGTTCTGTAAAGAAAGTTTTCCTGGCCCCATCC
CTTTGCATCAGCATGAACGTTACCTTTGTAAGATGAATGAAGAGATCAAGGCGGTCCTGCAGCCTCATGAAAACATAGTCCCCAACAAAG
CCGGAGTTTTTGTTGATAATAAAGCCCTCCTCTTGTCATCTGTACTTTCTGAGAAAGGAATGACAAGCCCCATCAACCCATACAAGGACC
ACATGTCTGTACTCAAAGCATACTATGCTATGAACATGGAGCCCAACTCCGATGAACTGCTGAAAATTTCCATTGCTGTGGGCCTTCCTC
AGGAATTTGTGAAGGAATGGTTTGAACAACGAAAAGTCTACCAGTACTCAAATTCCAGGTCCCCATCCCTGGAAAGAAGCTCCAAGCCGT
TAGCTCCCAACAGTAACCCTCCCACAAAAGACTCTTTATTACCCAGGTCTCCTGTAAAACCTATGGACTCCATAACATCACCATCTATAG
CAGAACTCCACAACAGTGTTACGAATTGTGATCCTCCTCTCAGGCTAACAAAACCTTCCCATTTTACCAATATTAAACCAGTTGAAAAAT
TGGACCACTCCAGGAGTAATACTCCTTCTCCCTTAAATCTTTCCTCCACATCTTCTAAAAACTCCCACAGTAGTTCATACACTCCAAACA
GCTTCTCTTCTGAGGAGCTCCAGGCTGAGCCTTTAGACTTGTCATTACCAAAACAAATGAAAGAACCCAAAAGTATTATAGCCACAAAGA
ACAAAACAAAAGCTAGTAGCATCAGTTTAGATCATAACAGTGTTTCTTCCTCATCTGAAAACTCAGATGAGCCTCTGAACTTGACTTTTA
TCAAGAAGGAATTTTCAAATTCAAATAATCTGGACAACAAAAGCACTAACCCAGTGTTCAGCATGAACCCATTTAGTGCCAAACCTTTAT
ACACAGCTCTTCCACCTCAAAGCGCATTTCCCCCTGCTACTTTCATGCCACCAGTCCAGACCAGTATTCCTGGGCTACGACCATACCCAG
GACTGGATCAGATGAGCTTCCTACCACATATGGCCTACACCTACCCAACTGGAGCAGCTACTTTTGCTGATATGCAGCAAAGGAGAAAGT
ACCAGCGGAAACAAGGATTTCAGGGAGAATTGCTTGATGGAGCACAAGACTACATGTCAGGCCTAGATGATATGACAGACTCCGACTCCT
GTCTGTCTCGCAAAAAGATCAAGAAGACAGAGAGTGGCATGTATGCATGTGACTTATGTGACAAGACATTCCAGAAAAGCAGTTCCCTTC
TGCGACATAAATACGAACACACAGGAAAAAGACCACATCAGTGTCAGATTTGTAAGAAAGCGTTTAAACACAAGCACCACCTTATCGAGC
ACTCAAGGCTTCACTCGGGCGAGAAGCCCTATCAGTGTGATAAATGTGGCAAGCGCTTCTCACACTCGGGCTCGTACTCGCAGCACATGA
ATCACAGGTATTCCTACTGCAAGCGGGAGGCGGAGGAGCGGGAAGCGGCGGAGCGCGAGGCGCGCGAGAAAGGGCACTTGGAACCCACCG
AGCTGCTGATGAACCGGGCTTACTTGCAGAGCATTACCCCTCAGGGGTACTCTGACTCGGAGGAGAGGGAGAGTATGCCGAGGGATGGCG
AGAGCGAGAAGGAGCACGAGAAAGAAGGCGAGGATGGCTACGGGAAGCTGGGCAGACAGGATGGCGACGAGGAGTTCGAGGAGGAAGAGG
AAGAAAGTGAAAATAAAAGTATGGATACGGATCCCGAAACGATACGAGATGAAGAAGAGACTGGAGATCACTCCATGGACGATAGTTCGG
AGGATGGGAAAATGGAAACCAAATCAGACCACGAGGAAGACAATATGGAAGATGGCATGTAATAAACTACTGCATTTTAAGCTTCCTATT
TTTTTTTCCAGTAGTATTGTTACCTGCTTGAAAACACTGCTGTGTTAAGCTGTTCATGCACGTGCCTGACGCTTCCAGGAAGCTGTAGAG
AGGGACAGAAGGGGCGGTTCAGCCAAGACAGATGTAGACGGAGTTGGAGCTGGGTATTGTTAAAAACTGCATTATGCAAAAATTTTGTAC
AGTGTTAAGGCCTAAAAACTGTGTGGTTCAGAGACTAATTCCTGTGTTTAATAGCATTTATACTTTAAGCACAACTAGAAAATTGTAAGA
ATTGCACTCTACTTATGTATCACTACAAACTTTAAAAAACTATGTCTAATTTATATTAATACATTTTAAAAAGGTGCCCGCACTACCATA
CATCAGTATTTTTATTATTATTATTGTTATTCCTTTTTAATTTAATGTGCTCGCACTACAATGCATCAGTATTATGATTCCTCTGTACTT
TCCTTTCGCTATTCATCAATTTCCCATTTTTTTTTTCAGCTTAAGTAACCACACAATTTTAGGCCTCAATTTTTTTTTTTTTCTGTGAAG
GAACTTGAAGTGATGCATGTGTGAATTTAAGATACCGAAGTCTTAAAGTGACCTGGACGTGAAGGAAAAAGTAAGATGAGAAATAAAGAA
AGCCTTTGTAAGGTGGTTTTAAAAGCCTTATATGCAAACCTTTTAATCTGTGTTTCTGCAAGTGCCATCCTTGTACAGTGTTAAGAGGGT
AACATGGGTTACCTTTGCACCAGCTTCAGTGTTAAGCTCACCCTGTTCTTTGAAGCACCCATGTCAGTATTAGAAGAATAGGCAGCAGTT
CCTTAGTTTACATATGTTTGTGCAATTATTTTCTGTACTTTTTTGTTCATTAATTTTGTCAGTATTACACCAAACTGTTTTTGCAACAAA
AAAATTTTTTTTGCATTCATTTAATTTTAGGTCAAATAACATTTTATTTATGTGGCTCATTTTATATTTCCTAATTTTATTTATTTCATA
CTGTAGTGTACAGTATTATAGTTCTTCAATATATAGATATATTTTAGTAAAAAAGGAACATGACGTTGATCATTTGGGCAAATTTTACGT
AAAGAGAAGAGCATTTATTGTGTTTTGGAACATTAATTGTGAGATGGGATTTTTCAATTTTATTATTTTATTTTTGTTTTTTTCCAATTA
CTGGAAATTCCAAATTTGGGAACTTTTGATACGATCTTGTGAAAACACTGTATTTTCGACTGAAAATTCCACTTTCTTCATCTTGTTTTT
TAGCTAAAAAGAGGGACTGTTAAATACAATGTATGATACCATGACAAAAATCTTTCCTGAATTGTCTTTGTAAAAGTATTATTGAATTTT
CAATTTGTAATTTCTTTTGAAAATGACCATGCTCGAATAAAAATGTAGCCAAACTAAGAATGTAGTTAATGAGTTCTGTACTTTTAGAGA
GTTTTCCTTCAATGACCATTAACATGTAACATGCTTTATGCTTATAATAATGCTAATTATGTTTTTTTCATATAATTTTAGTTTAGCAAT
AATTTTGACTGGTACCAATAACTGTTTTTTAAAATTCCATACCTATGTACAGCAATTTTACAGCTTTTCTCAACTGATCCTGATTCCAGA
TTGTGTATTTTTATGTGAGGTTATATTATTCAAATTTAGTCTATTTACTTTACAGACATTTCTACTTTTGCATTACGAGTATTTAGAGAT
TATGTGTTAAAAATTCACTTCTCTGTCCAAGGGGTCTTTGTGATTTATTCAAAAAAAAGTCTAATTTCAAAAAGACAGCTATTATTCAGT
GTTATTTATAATATGTAACCTTTTTTAAAGGATTGGGATAGTTTATCTCACTTTTTGAAATGCAGACAGTAGTTTACCGTTTATCTGAAA
CTAGAAGGCGTGGGTGGGAGAGGAAAAGCTAAAAGCAAATGCTAACAAAAATAACCGTGATTTTCTAAGACAGTTTTTCAGTTTTTACAA
GATGACCCTAATATTCAGAATATGAATGTATTCGTAGGTTTTACATAATGACTTTTATCAAGAAACTAGATTCTGCTTCTTAAATCTAAT
TGCCAAGTGAAGAATAACAGAAAAAACAGATTACCTTATCAAATTTACAGCTCTTGAATATACAGAACTATAATATAGTAGCTGTCCATG
TATTTTTTCTACTTTAGAATCAAAGAAGAAAAGCATCATTTTGCTATTAAATTTGCTAAAATTTTGAGTATGATATTTCCAGTTGGCAAG
AACAACATATTTATATTTATTCCTTAGCCATAATACCACTTTCCTAAATTTCACAAAAGTCATTCTTTGCAACTTGAAACTCAATAGAAA
GTGTGTATGTGTGTGTGTGTATATATATATATATATACACACACACACATACACAGAAAGGATGTAATGAAGATACAGTAATAGTTGAGC
AGACCTTTTTAGAAAAACATGTTTTTAGCTCTATCTTCAAACTTTCTGGCAGAGGGGGTGGGGGGGGCAGGGGGAGGAGTGGCATCAAAA
TGCTATGCCTCCTGTTATCCACAGCCTAGAGTTTTTATATTTGGAAAGTTTAGAAAATTCTATCCTCGTTTCTCCTTCTTTGAATGGCAC
AAATAAATACACTACATAAATTTTTCTGGTTTGAAAGGCTCTAGGCGATAACTTTATTAATTCAACCTGAAAATATCAAGCCATTAAATT
TTGTCCGGGTAGAATAAATCCCTGTGGCCTCTTTTAAAGCAATGTAGGTCTCTGTTGCCCATGGGGCATATCTGTGTCCCAATCCACAAG
AGATAGGACCAACAAACAATGAATGTGCAACCTAACTCTTTCTCCTTGGAAAGAAGAAAGTGTGCACGAAGTAGAGGAGGGTGGGCAGAC
CCTGCCTTGCCCCTCCTGTTACCCCCTTCTCTGTCATTTGTTCCTAACTCCATTTCATAGGCAGGCTCAGAATACCTGAGTCTGAAAATA
TCAGGATAACACTTGTGAATTGTGACAATCACTACAATGTCCCATATCTGAGGAGTTTTTTTTAATGCTATTTATCCGCTGGACACGATT
GCACATTAGGGCTGCATAATCCTCTAACTCTAGGGAAAAATAAAAACTTTTGATTTGTCTTAAGATTCTTCTCCAAGGTCGCAAACAAGA
AATTCCCCTCCACAACCAAGAGATGTGCATTTTAGTAACATCAGATGTGTTCTTCTGTTTTATCAACTACTTACTCTTCCCACACGCTTA
GTTCTAAATCTAACCTTTCCCCCCTCGAATAGGGGGCAGGGGAGGATGAGGAAACACTGGAACAACTGAACACCCCTGCCCATTTTCTCC
AAGAGCCTTTTGTATTCTAGCATATCTGTGCAATCTTTTCTTTTTTCTTCACATGACACTGTAAGCTTAGGCCTGAAATAACTGGGAAGA
GAGATGCGTATCAGAATTTCTCCGCAAGAGCTAAACAAAACATACATCTTCCTTAGCATGAATTGGACTGGGGGCGGAGTGGGAGGGCTT
GGAGGAAAGGGGAAAGAAGGGACTATATTTGAATAAATATGAATAAATGTATTAGATACTTTTCACAATCAGATAACTTTTAAAAAGGTC
ATTTTTTATCTTTCTAATAATGTAAGCCTTAATAAAAGCAAATCTTAGTCACAAATTTGAGGAGACTGCCCAATAATAAGTTTACATGTA
TTTGAACTGAAAAATTGTTAACCATGCTTTTGCTCCAAGATGTGTGAGGCCATTCAGGGGCTGTAGGGCCCTGGATATACACACAAACAA
GTGTGTGTATATCTGGAGCCCCACACATTGTAATAAACACAGCTGCATTTATTTGACTATGTGATCCCATGTACATGTAAAAACATTCAA
ACAAACACACTCAGCGGATTTATTTATTGTGCAATGGGGCAATTATTCAAATAAACATGCTCAATGCAATTATTTGAATCTCACATTGCA
TGTTCATCAATCATAGCACTAAAAAAAGAGGGGGAAAAAACACCAAAGAATTCACATGGGGAAAAAATATATATATGAAAACCACCTTAT
TATAGATTTTATAGGGCAGCTGAGGTTATGGCTCCCTTCTTAACTGTAACTCAACTATTCTGTATTCAATGACATTTGTTTCTAATGATT
AATTGGTTCACTCACTTGATCATATAATAGCAAACTTTATAAACCTGTATTGTGTAGAGATGTGAAATCTCTATATTTCAAGAGCAGAAG
AGTTCTTTCTAGACACCTTACATCAAGGGACACTGGTCCAATTATTATCGCTTATATAAGCACTCCTATAAATTCTGAAAAATTTTATAC
ATGCAACAAAACATTCCTACATTTGAAGACATTAAGAAAAATCACAGGTGACTCATCTGATCATTCTATATATTAATAAATATTATGACA
TATATGTGAACACATCACAAATCATATTGGTGTACCAAGAGGCAATTTATGCCTCTCTTAAGTATGTACTGACATAACCTAATATACTAA
AATGGGAAGGGGCTTTTAGTCACTGAAATATGCATCGTGTAACAAAGATGAAGAAAATACATGGCTTGTGCCCATCATAAAAAAAGATTC
AGACTGAAGGCTTAGCTTTGGTTTTTTCAATTAAATTGTTAAACTGTGCACAGTGATTTTTTTTTAGAACTTGAGACATTTGTGATGTTG
GCTGTTTAAATCTTTGTTACCTTCGCTGTGAATTGAAATTGTACATATTTAGTAAATCATGCAGACAAAACAAACTTTTTAGACAATATT
TTTATTGGAGAGTTTTCTTTTCCTGTATCCATGTTAAAAAAAAAAAAGACCTCCTTTCCCAAAATAAAAATGTCAATACTAAATTTAAAG
AAGTATAAAGGAATGATTGCTTCCTTTAGAGCAAAATATTTAAATAAACATGGAGATAATTGGCAACATGTTCTTTTTGGGCTAGTAGGC
TGTGTCCAATTTTTTGGGTCTGATGTTTCAGAGGGCCTCTGTTTCAGGGTTGAAGATGATATATTAATCTCGGAATTAAACAAATGCTAT
TAAATAACAGAAATAAATCCTTCAGTCTTCATTTGTATCTGAAATGTGGAATTAGTCAGAGAAATGGCACCGAGATAATATGATGCTGAA
TATGCCACAAGCTAAAACTTTCTCTATTAAACGAGTCGCCTACTACCTATAATCTAGCATGACATGTTAAAATGCTCCAAAATACTGAAA
ATAGAAAATGAACACTACTGTTCCGATTTGGTCTTGAGATTAATATGACAAAGATTCTAATAATTTTAGTCAAAGAAAATGATGAGTAAA

>5955_5955_4_ARHGAP15-ZEB2_ARHGAP15_chr2_144314054_ENST00000295095_ZEB2_chr2_145187593_ENST00000558170_length(amino acids)=1524AA_BP=334
MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHRRNHSQHILKDVIPPLEQLMVEKEGYLQKAK
IADGGKKLRKNWSTSWIVLSSRRIEFYKESKQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDW
FHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHHSASDTSDKNRVKSRLKKFITRRPSLKTLQE
KGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQVVNYDNVVDTGSETDEEDKLHIAEDD
GIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPEEMKEDYDTMGPEATIQTAINNGTVKNANC
TSDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHI
KYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFS
HSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFS
GTSPFMNGGLGATSPLGVHPSAQSPMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKAEEISKLKGYHMKDPCSQPEE
QGVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHNISTPFSCQFCKESF
PGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNKAGVFVDNKALLLSSVLSEKGMTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIA
VGLPQEFVKEWFEQRKVYQYSNSRSPSLERSSKPLAPNSNPPTKDSLLPRSPVKPMDSITSPSIAELHNSVTNCDPPLRLTKPSHFTNIK
PVEKLDHSRSNTPSPLNLSSTSSKNSHSSSYTPNSFSSEELQAEPLDLSLPKQMKEPKSIIATKNKTKASSISLDHNSVSSSSENSDEPL
NLTFIKKEFSNSNNLDNKSTNPVFSMNPFSAKPLYTALPPQSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQ
QRRKYQRKQGFQGELLDGAQDYMSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAFKHKH
HLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEEREAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARHGAP15-ZEB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGAP15-ZEB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGAP15-ZEB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource