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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGAP17-TACC1 (FusionGDB2 ID:5961)

Fusion Gene Summary for ARHGAP17-TACC1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP17-TACC1
Fusion gene ID: 5961
HgeneTgene
Gene symbol

ARHGAP17

TACC1

Gene ID

55114

6867

Gene nameRho GTPase activating protein 17transforming acidic coiled-coil containing protein 1
SynonymsMST066|MST110|MSTP038|MSTP066|MSTP110|NADRIN|PP367|PP4534|RICH-1|RICH1|WBP15Ga55
Cytomap

16p12.1

8p11.22

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 17RhoGAP interacting with CIP4 homologs 1neuron-associated developmentally regulated proteinrho-type GTPase-activating protein 17transforming acidic coiled-coil-containing protein 1gastric cancer antigen Ga55taxin-1
Modification date2020031320200320
UniProtAcc

Q68EM7

O75410

Ensembl transtripts involved in fusion geneENST00000441763, ENST00000289968, 
ENST00000303665, ENST00000575975, 
ENST00000443286, ENST00000518415, 
ENST00000520340, ENST00000276520, 
ENST00000317827, ENST00000330691, 
ENST00000348567, ENST00000379931, 
ENST00000519416, ENST00000520611, 
ENST00000520615, ENST00000520973, 
ENST00000522752, 
Fusion gene scores* DoF score6 X 5 X 5=15018 X 21 X 10=3780
# samples 623
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/3780*10)=-4.03868046816406
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP17 [Title/Abstract] AND TACC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP17(24953308)-TACC1(38599869), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARHGAP17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TACC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A1X6-01AARHGAP17chr16

24953308

-TACC1chr8

38599869

+


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Fusion Gene ORF analysis for ARHGAP17-TACC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000441763ENST00000443286ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
3UTR-5UTRENST00000441763ENST00000518415ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
3UTR-5UTRENST00000441763ENST00000520340ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
3UTR-intronENST00000441763ENST00000276520ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
3UTR-intronENST00000441763ENST00000317827ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
3UTR-intronENST00000441763ENST00000330691ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
3UTR-intronENST00000441763ENST00000348567ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
3UTR-intronENST00000441763ENST00000379931ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
3UTR-intronENST00000441763ENST00000519416ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
3UTR-intronENST00000441763ENST00000520611ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
3UTR-intronENST00000441763ENST00000520615ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
3UTR-intronENST00000441763ENST00000520973ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
3UTR-intronENST00000441763ENST00000522752ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
5CDS-5UTRENST00000289968ENST00000443286ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
5CDS-5UTRENST00000289968ENST00000518415ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
5CDS-5UTRENST00000289968ENST00000520340ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
5CDS-5UTRENST00000303665ENST00000443286ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
5CDS-5UTRENST00000303665ENST00000518415ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
5CDS-5UTRENST00000303665ENST00000520340ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
5CDS-intronENST00000289968ENST00000276520ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
5CDS-intronENST00000289968ENST00000317827ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
5CDS-intronENST00000289968ENST00000330691ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
5CDS-intronENST00000289968ENST00000348567ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
5CDS-intronENST00000289968ENST00000379931ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
5CDS-intronENST00000289968ENST00000519416ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
5CDS-intronENST00000289968ENST00000520611ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
5CDS-intronENST00000289968ENST00000520615ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
5CDS-intronENST00000289968ENST00000520973ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
5CDS-intronENST00000289968ENST00000522752ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
5CDS-intronENST00000303665ENST00000276520ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
5CDS-intronENST00000303665ENST00000317827ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
5CDS-intronENST00000303665ENST00000330691ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
5CDS-intronENST00000303665ENST00000348567ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
5CDS-intronENST00000303665ENST00000379931ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
5CDS-intronENST00000303665ENST00000519416ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
5CDS-intronENST00000303665ENST00000520611ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
5CDS-intronENST00000303665ENST00000520615ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
5CDS-intronENST00000303665ENST00000520973ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
5CDS-intronENST00000303665ENST00000522752ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
intron-5UTRENST00000575975ENST00000443286ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
intron-5UTRENST00000575975ENST00000518415ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
intron-5UTRENST00000575975ENST00000520340ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
intron-intronENST00000575975ENST00000276520ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
intron-intronENST00000575975ENST00000317827ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
intron-intronENST00000575975ENST00000330691ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
intron-intronENST00000575975ENST00000348567ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
intron-intronENST00000575975ENST00000379931ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
intron-intronENST00000575975ENST00000519416ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
intron-intronENST00000575975ENST00000520611ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
intron-intronENST00000575975ENST00000520615ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
intron-intronENST00000575975ENST00000520973ARHGAP17chr16

24953308

-TACC1chr8

38599869

+
intron-intronENST00000575975ENST00000522752ARHGAP17chr16

24953308

-TACC1chr8

38599869

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ARHGAP17-TACC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARHGAP17chr1624953307-TACC1chr838599868+5.35E-070.9999995
ARHGAP17chr1624953307-TACC1chr838599868+5.35E-070.9999995

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARHGAP17-TACC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:24953308/:38599869)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP17

Q68EM7

TACC1

O75410

FUNCTION: Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}.FUNCTION: Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ARHGAP17-TACC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ARHGAP17-TACC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGAP17-TACC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGAP17-TACC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource