FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ARHGAP17-TNRC6A (FusionGDB2 ID:5962)

Fusion Gene Summary for ARHGAP17-TNRC6A

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP17-TNRC6A
Fusion gene ID: 5962
HgeneTgene
Gene symbol

ARHGAP17

TNRC6A

Gene ID

55114

27327

Gene nameRho GTPase activating protein 17trinucleotide repeat containing adaptor 6A
SynonymsMST066|MST110|MSTP038|MSTP066|MSTP110|NADRIN|PP367|PP4534|RICH-1|RICH1|WBP15CAGH26|FAME6|GW1|GW182|TNRC6
Cytomap

16p12.1

16p12.1

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 17RhoGAP interacting with CIP4 homologs 1neuron-associated developmentally regulated proteinrho-type GTPase-activating protein 17trinucleotide repeat-containing gene 6A proteinCAG repeat protein 26CTD-2540M10.1EDIEEMSY interactor proteinGW182 autoantigenglycine-tryptophan protein of 182 kDatrinucleotide repeat containing 6A
Modification date2020031320200313
UniProtAcc

Q68EM7

.
Ensembl transtripts involved in fusion geneENST00000441763, ENST00000289968, 
ENST00000303665, ENST00000575975, 
ENST00000315183, ENST00000395799, 
ENST00000432286, ENST00000562829, 
Fusion gene scores* DoF score6 X 5 X 5=15017 X 17 X 4=1156
# samples 617
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1156*10)=-2.76553474636298
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP17 [Title/Abstract] AND TNRC6A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP17(24953308)-TNRC6A(24762047), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTNRC6A

GO:0035278

miRNA mediated inhibition of translation

17671087


check buttonFusion gene breakpoints across ARHGAP17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TNRC6A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-S3-AA0Z-01AARHGAP17chr16

24953308

-TNRC6Achr16

24762047

+


Top

Fusion Gene ORF analysis for ARHGAP17-TNRC6A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000441763ENST00000315183ARHGAP17chr16

24953308

-TNRC6Achr16

24762047

+
3UTR-intronENST00000441763ENST00000395799ARHGAP17chr16

24953308

-TNRC6Achr16

24762047

+
3UTR-intronENST00000441763ENST00000432286ARHGAP17chr16

24953308

-TNRC6Achr16

24762047

+
3UTR-intronENST00000441763ENST00000562829ARHGAP17chr16

24953308

-TNRC6Achr16

24762047

+
5CDS-intronENST00000289968ENST00000395799ARHGAP17chr16

24953308

-TNRC6Achr16

24762047

+
5CDS-intronENST00000289968ENST00000432286ARHGAP17chr16

24953308

-TNRC6Achr16

24762047

+
5CDS-intronENST00000289968ENST00000562829ARHGAP17chr16

24953308

-TNRC6Achr16

24762047

+
5CDS-intronENST00000303665ENST00000395799ARHGAP17chr16

24953308

-TNRC6Achr16

24762047

+
5CDS-intronENST00000303665ENST00000432286ARHGAP17chr16

24953308

-TNRC6Achr16

24762047

+
5CDS-intronENST00000303665ENST00000562829ARHGAP17chr16

24953308

-TNRC6Achr16

24762047

+
In-frameENST00000289968ENST00000315183ARHGAP17chr16

24953308

-TNRC6Achr16

24762047

+
In-frameENST00000303665ENST00000315183ARHGAP17chr16

24953308

-TNRC6Achr16

24762047

+
intron-3CDSENST00000575975ENST00000315183ARHGAP17chr16

24953308

-TNRC6Achr16

24762047

+
intron-intronENST00000575975ENST00000395799ARHGAP17chr16

24953308

-TNRC6Achr16

24762047

+
intron-intronENST00000575975ENST00000432286ARHGAP17chr16

24953308

-TNRC6Achr16

24762047

+
intron-intronENST00000575975ENST00000562829ARHGAP17chr16

24953308

-TNRC6Achr16

24762047

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000289968ARHGAP17chr1624953308-ENST00000315183TNRC6Achr1624762047+96631560772482413
ENST00000303665ARHGAP17chr1624953308-ENST00000315183TNRC6Achr1624762047+96631560772482413

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000289968ENST00000315183ARHGAP17chr1624953308-TNRC6Achr1624762047+0.0005857370.9994143
ENST00000303665ENST00000315183ARHGAP17chr1624953308-TNRC6Achr1624762047+0.0005857370.9994143

Top

Fusion Genomic Features for ARHGAP17-TNRC6A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARHGAP17chr1624953307-TNRC6Achr1624762046+1.31E-070.9999999
ARHGAP17chr1624953307-TNRC6Achr1624762046+1.31E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ARHGAP17-TNRC6A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:24953308/chr16:24762047)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP17

Q68EM7

.
FUNCTION: Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP17chr16:24953308chr16:24762047ENST00000289968-162014_246496882.0DomainBAR
HgeneARHGAP17chr16:24953308chr16:24762047ENST00000289968-1620252_442496882.0DomainRho-GAP
HgeneARHGAP17chr16:24953308chr16:24762047ENST00000303665-161914_246496804.0DomainBAR
HgeneARHGAP17chr16:24953308chr16:24762047ENST00000303665-1619252_442496804.0DomainRho-GAP
HgeneARHGAP17chr16:24953308chr16:24762047ENST00000441763-151914_246469762.3333333333334DomainBAR
HgeneARHGAP17chr16:24953308chr16:24762047ENST00000441763-1519252_442469762.3333333333334DomainRho-GAP
TgeneTNRC6Achr16:24953308chr16:24762047ENST00000315183124192_365171914.0Compositional biasNote=Ser-rich
TgeneTNRC6Achr16:24953308chr16:24762047ENST0000031518312493_127171914.0Compositional biasNote=Gln-rich
TgeneTNRC6Achr16:24953308chr16:24762047ENST00000395799125192_365171963.0Compositional biasNote=Ser-rich
TgeneTNRC6Achr16:24953308chr16:24762047ENST0000039579912593_127171963.0Compositional biasNote=Gln-rich
TgeneTNRC6Achr16:24953308chr16:24762047ENST000003151831241781_1853171914.0DomainNote=RRM
TgeneTNRC6Achr16:24953308chr16:24762047ENST000003957991251781_1853171963.0DomainNote=RRM
TgeneTNRC6Achr16:24953308chr16:24762047ENST000003151831241604_1622171914.0RegionNote=PABPC1-interacting motif-2 (PAM2)
TgeneTNRC6Achr16:24953308chr16:24762047ENST000003957991251604_1622171963.0RegionNote=PABPC1-interacting motif-2 (PAM2)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP17chr16:24953308chr16:24762047ENST00000289968-1620521_816496882.0Compositional biasNote=Pro-rich
HgeneARHGAP17chr16:24953308chr16:24762047ENST00000303665-1619521_816496804.0Compositional biasNote=Pro-rich
HgeneARHGAP17chr16:24953308chr16:24762047ENST00000441763-1519521_816469762.3333333333334Compositional biasNote=Pro-rich
HgeneARHGAP17chr16:24953308chr16:24762047ENST00000289968-1620753_766496882.0MotifSH3-binding
HgeneARHGAP17chr16:24953308chr16:24762047ENST00000303665-1619753_766496804.0MotifSH3-binding
HgeneARHGAP17chr16:24953308chr16:24762047ENST00000441763-1519753_766469762.3333333333334MotifSH3-binding
TgeneTNRC6Achr16:24953308chr16:24762047ENST000003151831247_54171914.0Coiled coilOntology_term=ECO:0000255
TgeneTNRC6Achr16:24953308chr16:24762047ENST000003957991257_54171963.0Coiled coilOntology_term=ECO:0000255


Top

Fusion Gene Sequence for ARHGAP17-TNRC6A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5962_5962_1_ARHGAP17-TNRC6A_ARHGAP17_chr16_24953308_ENST00000289968_TNRC6A_chr16_24762047_ENST00000315183_length(transcript)=9663nt_BP=1560nt
GTAGTAGCTGCCAGGCTGTCCCCCGCCCTGCCCGGCCCGAGCCCCGCGGGCCGCCGCCGCCACCGCCGCCATGAAGAAGCAGTTCAACCG
CATGAAGCAGCTGGCTAACCAGACCGTGGGCAGAGCTGAGAAAACAGAAGTCCTTAGTGAAGATCTATTACAGATTGAGAGACGCCTGGA
CACGGTGCGGTCAATATGCCACCATTCCCATAAGCGCTTGGTGGCATGTTTCCAGGGCCAGCATGGCACCGATGCCGAGAGGAGACACAA
AAAACTGCCTCTGACAGCTCTTGCTCAAAATATGCAAGAAGCATCGACTCAGCTGGAAGACTCTCTCCTGGGGAAGATGCTGGAGACGTG
TGGAGATGCTGAGAATCAGCTGGCTCTCGAGCTCTCCCAGCACGAAGTCTTTGTTGAGAAGGAGATCGTGGACCCTCTGTACGGCATAGC
TGAGGTGGAGATTCCCAACATCCAGAAGCAGAGGAAGCAGCTTGCAAGATTGGTGTTAGACTGGGATTCAGTCAGAGCCAGGTGGAACCA
AGCTCACAAATCCTCAGGAACCAACTTTCAGGGGCTTCCATCAAAAATAGATACTCTAAAGGAAGAGATGGATGAAGCTGGAAATAAAGT
AGAACAGTGCAAGGATCAACTTGCAGCAGACATGTACAACTTTATGGCCAAAGAAGGGGAGTATGGCAAATTCTTTGTTACGTTATTAGA
AGCCCAAGCAGATTACCATAGAAAAGCATTAGCAGTCTTAGAAAAGACCCTCCCCGAAATGCGAGCCCATCAAGATAAGTGGGCGGAAAA
ACCAGCCTTTGGGACTCCCCTAGAAGAACACCTGAAGAGGAGCGGGCGCGAGATTGCGCTGCCCATTGAAGCCTGTGTCATGCTGCTTCT
GGAGACAGGCATGAAGGAGGAGGGCCTTTTCCGAATTGGGGCTGGGGCCTCCAAGTTAAAGAAGCTGAAAGCTGCTTTGGACTGTTCTAC
TTCTCACCTGGATGAGTTCTATTCAGACCCCCATGCTGTAGCAGGTGCTTTAAAATCCTATTTACGGGAATTGCCTGAACCTTTGATGAC
TTTTAATCTGTATGAAGAATGGACACAAGTTGCAAGTGTGCAGGATCAAGACAAAAAACTTCAAGACTTGTGGAGAACATGTCAGAAGTT
GCCACCACAAAATTTTGTTAACTTTAGATATTTGATCAAGTTCCTTGCAAAGCTTGCTCAGACCAGCGATGTGAATAAAATGACTCCCAG
CAACATTGCGATTGTGTTAGGCCCTAACTTGTTATGGGCCAGAAATGAAGGAACACTTGCTGAAATGGCAGCAGCCACATCCGTCCATGT
GGTTGCAGTGATTGAACCCATCATTCAGCATGCCGACTGGTTCTTCCCTGAAGAGGTGGAATTTAATGTATCAGAAGCATTTGTACCTCT
CACCACCCCGAGTTCTAATCACTCATTCCACACTGGAAACGACTCTGACTCGGGGACCCTGGAGAGGAAGCGGCCTGCTAGCATGGCGGT
GATGGAAGGAGACTTGGTGAAGAAGGAAAGGGATTTAGTGCAAGAAGAAGAACAGTTGATGGAAGAAAAGAAAAAGAAAAAAGACGACAA
GAAAAAGAAGGAAGCTGCTCAAAAGAAGGCCACTGAACAAAAAATCAAAGTGCCAGAACAGATAAAGCCCAGTGTAAGCCAGCCTCAGCC
TGCCAACTCTAATAACGGCACTTCCACAGCAACCAGCACTAATAATAATGCCAAGCGAGCTACAGCCAACAATCAGCAGCCACAGCAGCA
GCAGCAACAGCAGCAGCCGCAGCAGCAGCAGCCACAGCAGCAGCCACAGCCGCAGCCGCAGCAGCAGCAGCCACAGCAGCAGCCACAGGC
CTTGCCTCGGTATCCTCGTGAAGTACCTCCACGATTTCGCCACCAGGAACACAAACAGCTTCTAAAGAGGGGTCAGCATTTTCCTGTTAT
AGCAGCAAACCTTGGATCTGCTGTTAAGGTGTTAAACAGCCAGTCAGAAAGCAGTGCTTTAACAAATCAACAGCCACAAAATAACGGAGA
GGTGCAGAACAGCAAAAACCAGTCAGATATAAACCACAGTACTTCAGGATCCCATTATGAAAATTCCCAGCGGGGACCTGTGTCTTCTAC
AAGTGATTCTAGCACAAACTGTAAGAATGCTGTTGTAAGTGACTTGTCGGAAAAAGAAGCATGGCCCTCAGCCCCTGGCAGTGATCCGGA
GTTGGCTTCAGAATGTATGGATGCTGATTCTGCCTCCAGTTCTGAATCAGAGAGAAACATCACTATCATGGCTTCAGGGAACACAGGTGG
TGAAAAAGATGGCCTTCGGAATAGCACTGGACTTGGTTCCCAAAACAAGTTTGTAGTTGGTAGCAGCAGCAATAATGTGGGCCATGGAAG
TAGTACTGGGCCATGGGGTTTTTCCCATGGAGCCATAATAAGCACATGTCAGGTCTCTGTGGATGCTCCTGAAAGCAAATCTGAAAGTAG
CAACAATAGAATGAATGCTTGGGGCACTGTAAGTTCTTCATCAAATGGAGGGTTAAATCCAAGCACTTTGAATTCAGCTAGCAACCATGG
TGCCTGGCCAGTATTAGAGAACAATGGACTTGCCCTAAAAGGGCCTGTAGGGAGTGGTAGTTCTGGCATTAATATTCAGTGCAGTACTAT
AGGCCAGATGCCTAACAATCAGAGTATTAACTCTAAAGTGAGTGGTGGTTCTACCCATGGTACCTGGGGAAGCCTTCAGGAAACTTGTGA
ATCTGAAGTAAGTGGTACACAGAAGGTTTCATTCAGTGGTCAACCTCAAAATATTACCACTGAAATGACTGGACCAAATAACACTACTAA
CTTTATGACCTCTAGTTTACCAAACTCCGGTTCAGTGCAGAATAATGAGCTGCCTAGTAGTAACACAGGGGCCTGGCGTGTGAGCACAAT
GAATCATCCTCAGATGCAGGCTCCATCAGGTATGAATGGCACTTCCCTTTCTCACCTTAGCAATGGAGAGTCAAAAAGTGGAGGCTCTTA
TGGTACTACATGGGGTGCCTATGGTTCTAATTACTCTGGAGACAAATGTTCAGGCCCTAATGGCCAAGCTAATGGTGACACTGTGAATGC
AACTCTAATGCAGCCTGGCGTAAATGGTCCTATGGGCACTAACTTTCAAGTTAACACAAACAAAGGAGGTGGTGTGTGGGAATCTGGTGC
AGCAAACTCCCAGAGTACATCATGGGGAAGTGGAAATGGCGCAAATTCTGGAGGAAGTCGAAGAGGATGGGGAACCCCTGCACAAAACAC
TGGCACTAATTTACCCAGCGTTGAGTGGAACAAACTGCCTAGCAATCAGCATTCCAATGATAGTGCAAATGGCAATGGTAAGACGTTTAC
AAATGGATGGAAATCTACTGAGGAAGAGGATCAGGGTTCTGCCACATCTCAGACAAATGAGCAAAGCAGTGTGTGGGCCAAAACAGGAGG
TACAGTGGAGAGCGATGGTAGTACAGAAAGCACTGGACGCCTTGAGGAAAAAGGAACTGGGGAAAGTCAGAGTAGAGACAGAAGAAAAAT
TGATCAGCACACATTACTCCAAAGCATTGTAAACAGAACTGACTTAGATCCACGTGTCCTGTCCAACTCTGGTTGGGGACAGACTCCTAT
TAAGCAGAATACTGCCTGGGATACAGAAACATCACCTAGAGGGGAACGAAAGACTGACAATGGGACAGAGGCCTGGGGAAGCTCTGCAAC
ACAGACTTTTAACTCAGGGGCATGTATAGATAAGACTAGCCCTAATGGTAATGATACCTCATCTGTATCAGGGTGGGGCGATCCCAAACC
TGCTCTGAGGTGGGGAGATTCCAAAGGCTCAAACTGCCAGGGGGGGTGGGAAGATGATTCTGCTGCTACAGGAATGGTCAAGAGCAATCA
GTGGGGGAATTGCAAAGAGGAGAAGGCTGCATGGAATGACTCGCAAAAGAATAAACAGGGATGGGGTGATGGACAAAAATCAAGCCAAGG
GTGGTCTGTTTCTGCCAGTGATAACTGGGGAGAAACTTCAAGGAATAACCATTGGGGTGAGGCCAATAAGAAATCCAGCTCAGGAGGTAG
TGACAGTGACAGGTCCGTTTCCGGTTGGAACGAACTTGGTAAAACTAGTTCTTTCACTTGGGGAAACAACATAAATCCAAATAATTCATC
AGGATGGGATGAATCTTCTAAACCTACTCCTTCCCAGGGATGGGGAGACCCTCCAAAGTCTAATCAGTCTCTAGGTTGGGGAGATTCGTC
AAAGCCAGTCAGCTCTCCAGACTGGAACAAGCAACAAGACATTGTTGGATCTTGGGGAATCCCACCAGCTACAGGCAAACCTCCTGGTAC
AGGCTGGCTGGGGGGACCTATACCAGCCCCAGCAAAAGAAGAAGAACCCACAGGCTGGGAGGAACCATCCCCAGAATCTATACGTCGCAA
AATGGAGATTGATGATGGAACTTCAGCTTGGGGAGATCCAAGCAAATACAACTACAAAAATGTGAACATGTGGAACAAAAACGTCCCAAA
TGGCAACAGCCGTTCAGACCAGCAAGCACAGGTACATCAGCTGCTAACGCCTGCAAGTGCCATCTCAAACAAAGAGGCAAGCAGTGGCTC
TGGCTGGGGTGAGCCCTGGGGGGAGCCTTCTACTCCAGCCACAACTGTGGATAATGGTACTTCAGCATGGGGTAAGCCCATAGACAGTGG
TCCCAGCTGGGGGGAACCCATTGCTGCGGCATCCAGCACATCCACGTGGGGCTCCAGCTCTGTTGGTCCACAAGCATTAAGCAAATCTGG
GCCAAAATCTATGCAAGATGGCTGGTGTGGTGATGATATGCCATTGCCTGGAAATCGCCCCACTGGCTGGGAAGAGGAAGAGGATGTGGA
GATTGGAATGTGGAATAGTAATTCATCTCAAGAGCTTAACTCATCTTTAAATTGGCCACCATATACAAAGAAAATGTCATCGAAGGGTCT
GAGTGGCAAAAAAAGGAGAAGGGAAAGGGGAATGATGAAAGGTGGAAACAAACAAGAAGAAGCGTGGATAAATCCATTTGTTAAACAGTT
TTCAAACATCAGTTTTTCGAGAGACTCACCAGAGGAAAATGTACAAAGCAATAAGATGGACCTTTCTGGAGGAATGTTACAAGACAAACG
AATGGAGATAGATAAACATAGCCTAAATATTGGTGATTACAATCGAACGGTCGGGAAAGGCCCTGGTTCTCGGCCTCAGATTTCCAAAGA
GTCTTCCATGGAGCGCAATCCTTATTTTGATAAGAATGGCAATCCCAGTATGTTTGGTGTTGGAAACACAGCAGCACAACCCCGGGGCAT
GCAGCAGCCTCCAGCACAACCTCTTAGTTCATCTCAGCCTAATCTCCGTGCTCAAGTGCCTCCTCCATTACTCTCCCCTCAGGTTCCAGT
TTCATTGCTGAAGTATGCACCAAACAACGGTGGCCTGAATCCACTCTTTGGCCCTCAACAGGTAGCCATGCTGAACCAGCTATCCCAGCT
AAACCAGCTTTCTCAGATCTCCCAGTTACAGCGATTGTTAGCGCAGCAGCAAAGGGCGCAGAGTCAGAGAAGCGTGCCTTCTGGGAACCG
GCCGCAGCAAGACCAGCAGGGTCGACCTCTTAGTGTGCAGCAGCAAATGATGCAACAATCTCGTCAACTTGATCCAAACCTGTTGGTGAA
GCAGCAGACTCCACCATCTCAGCAGCAGCCACTCCATCAGCCAGCCATGAAGTCTTTCCTTGACAATGTCATGCCCCACACTACACCTGA
GCTGCAAAAAGGGCCATCACCAATAAATGCTTTCAGCAACTTCCCTATAGGCTTGAACTCAAACTTGAATGTAAATATGGATATGAACAG
TATTAAAGAGCCACAGTCAAGACTAAGGAAGTGGACGACAGTGGACAGCATTTCTGTGAACACATCTTTGGATCAAAACTCCAGCAAACA
TGGTGCTATTTCAAGTGGTTTCAGGCTGGAAGAGTCTCCATTTGTTCCCTATGACTTTATGAACAGCAGTACTTCACCAGCCAGTCCTCC
AGGTTCAATAGGAGATGGCTGGCCACGTGCCAAATCGCCTAACGGCTCTAGCAGTGTTAATTGGCCACCAGAATTTCGTCCTGGTGAGCC
ATGGAAAGGTTATCCAAACATTGACCCTGAAACTGACCCTTACGTCACTCCTGGCAGTGTCATAAACAATCTTTCAATTAATACTGTGCG
GGAAGTTGACCACCTCAGGGACAGGAACAGTGGGTCATCCTCATCCTTGAACACCACGCTGCCTTCAACTAGTGCCTGGTCATCCATTCG
TGCCTCCAACTACAACGTTCCCCTCAGCAGTACAGCACAAAGCACTTCAGCCAGAAATAGTGATTCCAAATTGACATGGTCTCCTGGTTC
AGTTACAAACACCTCTCTGGCTCATGAGCTGTGGAAGGTCCCTTTGCCACCTAAAAACATCACTGCTCCGTCCCGCCCACCTCCGGGACT
GACTGGTCAGAAGCCACCCTTGTCTACGTGGGATAATTCTCCCCTTCGTATAGGTGGAGGATGGGGAAATTCTGACGCCAGATATACCCC
AGGTTCCAGCTGGGGTGAGAGCAGCTCAGGGAGAATAACAAATTGGCTTGTTCTAAAAAACCTTACACCTCAGATCGATGGCTCAACTCT
GCGCACTCTGTGCATGCAGCACGGCCCGCTGATCACATTCCACCTGAACCTCCCTCACGGAAATGCTCTGGTCCGCTACAGTTCAAAAGA
AGAGGTAGTGAAGGCACAAAAGTCTCTGCACATGTGTGTACTGGGGAACACTACTATTCTTGCTGAGTTTGCCAGTGAAGAGGAGATCAG
TCGTTTCTTTGCACAAAGCCAGTCTCTGACCCCTTCTCCCGGCTGGCAGTCTCTCGGGTCCAGCCAGAGCCGGCTGGGCTCCCTCGACTG
TTCCCACTCATTCTCCAGCCGGACCGATCTCAATCACTGGAATGGTGCTGGGCTGTCGGGAACTAACTGTGGAGACCTTCACGGCACTTC
ACTCTGGGGGACCCCGCATTATTCCACAAGCCTGTGGGGTCCCCCAAGCAGCAGCGACCCCCGAGGAATTAGCAGCCCATCTCCCATTAA
CGCTTTTCTTTCTGTTGACCACCTGGGTGGGGGTGGAGAGTCCATGTAACAGTGTAGATGCAGACTCACCGACCGGGACCTCAGACGCGA
GGGAAAGGAGCACTAAGTGGGGCTCGCCGCCTGCAGCCAGGGGCCGCCTGTGGGAACAGCTATTCTCTGCACATTTTCCACTTTGTTTTC
CCCAAAACATATCAGTTTGAATACTTGAATCATGCAGGCCAATATTATAATGTGAAAAGGTATCTACTCTATTTACACTCCCAAATAGCG
CCATACATGCTAAACCGTAGAGAATGAGCTCGCTTGTGTCTATTCATCATGTTTAGCCTTTGGATTCTTTTTTTTTTTTTCCTTCTATTC
CTCCCCAACCCCCCCCCCCGCCCCTTTTTTTCTCTCTTGCAAAACCATTTTTTGGGCTGATAACGTATGAGCTTTTCCCTTTGCACTGAA
TGATGTTCTCTCCGTCTCATCGGCAGTATGGGGGGCAGCTGTCCCAGTGTCAATGTTTACTCAAGGGTGTTCTTAGGAGGCGTGCGCTCT
CTACTATGCCTTGATGTTGCCTACCTTATTGTGGTATCGTGGAGTTTAAAAGATCAAGTTAGGATGCTGACTTAGGATTATTAATGAAAG
TGTTGCACCAGTTTTTTCATGTTGTAAAACTAAAGAATTTCGCTCTGCAGTTTGAAAAACTGTGGCCACAGCTGTGACTTGCAGCCCACC
TGCCACCCAGGACGGGCCCTGCACTTTGAATAGGCTTTCCATTTTGTTTTGGAGGTTCTCACTTTGAACCTTCTTGTTTACAGATTTTTT
TGTTTGTTTTTTGAGAAAAAAAAATGTTTACTCTTCCATCATTTAAAAAAAATGTAAAAGACAAAAAAAAAATGGAGGATGATTTAAAAG
ATGCTTTCTATCTCTGGGAAAAAGGAGCAGCATTTGGCCATGTTCTTTTGTTTTTCTATTCCTGTCCCAAATCAAAGAGCATGGTTCTCA
GGAAAACCAGTTCCCCAGTTTAAAAAAAAAAAAAAAAATTCCTTGTAGTTTCTTAGAGGAAAAAAAGAAAAACCCCAACTTTTAGCACTG
ATACTACATATTGCTCTGTTAAAGAATTTTCTCTGCCAAAAAAAAAGAAAAAACAAAAAAACGCTTAAAGCTGGAGTTTGACATTCTGCT
TTCAGATGCTGTCTTTTTATTAGTGAGTGATGATGGTTTGCTAATAATCAATAGGTAATAATTTTTTGTAATCCCATCAAGTGGCTCCAT
ATGTTTCTGCTCTCTCGTGACTGTGTTAATGTTTAACTGTTGTACCTTAAAGCCGAAATCAGTAACTATGCATACTGTAACCAAGGTATT
GGGCTTACAGAGTTGTTTGTTGTATAAAGAAAATTTTAAATGTTGTTGCAAACTAACGAGTTACACCATTTTAAACTTTCTTTCCTCCCC
CCTTTTTTTGCCCACAAATGGTATTATAATGCTTGCTTAGTCAAAGAAGAGAGACTAAACAAGGGTAAAAATTTTAACAGTACAGAATTT
GCCATCATATCATTGCCTTGATTCTAACTGTTTGTGTCCTAAGATGCAAAAGAAGTCAGTGGCTTTTAACTGTTTACAAATAGAATGTGA
TTGTAAAATGTACAGTTTGGTTGTGTTTGAATTATGAAATTTCTTCAGATATAATAAACCATGACTTTTTGGCTGCTCAACATTAATTGT
CTCCTTTTTGTGAATTTATTTGTAGGCTCTTTTTTATAATGAAAGTTTCAAAGTTGCTATGTATGAGGGTTCTCATAGAGCAACCGATTA
AAAATCTAAGCAAATATTTGAACATTTTATCTGAACTCATCACAATTTCACCCTGAAATAATGTGAGAACAATGGGAAACTGTAGCTTGC
TCCTTCCCACCCTCTCTGAGCATCTTTGGGATCTTGTTGCTCAAAACTCTTCTGTGACTTCATCTTCCCCACCATTTGTGCCCATCTCAA
GCCTCAGCAAGAAACCATGTGGAACATGAAGCTTAATGACTTGACAGTGTACTAGTGTTAAACTCTCATACCTCTGTTACAAAGCGAGAA
ACGCCACACCCGGACTGGCCTTTTCTTCCCCCTTCACGGCCCTCGCTTCTCCCTGCAGGAGCTCGGGGGCGAAACCTGTGTATGGATTTC
AGTGTATGACTTCAGATCATGCTCCAACTTGCCAGGTGTGAGCTAATGTTGTCGGACACCTTACTATAAGCAAATGTTATTCAGTGCGTT
CAATGTATATTGACTTCCATACTGGTTTTTCCAAAAACCAAAGGTAGCTTTGAAAAACCATGTCTGGAAATGTTTGGAGCGTTAAGCTGA
TTGACCTTCTGACCTTGGGGCTTTGAGTAGTATATAATTCATAACTGCGTTAATTGTATTGTTAAAGTGTTTGGGAGTTTTTTGCGCTTG

>5962_5962_1_ARHGAP17-TNRC6A_ARHGAP17_chr16_24953308_ENST00000289968_TNRC6A_chr16_24762047_ENST00000315183_length(amino acids)=2413AA_BP=517
MPGCPPPCPARAPRAAAATAAMKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICHHSHKRLVACFQGQHGTDAERRHKKL
PLTALAQNMQEASTQLEDSLLGKMLETCGDAENQLALELSQHEVFVEKEIVDPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAH
KSSGTNFQGLPSKIDTLKEEMDEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKTLPEMRAHQDKWAEKPA
FGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFN
LYEEWTQVASVQDQDKKLQDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMAAATSVHVVA
VIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSSNHSFHTGNDSDSGTLERKRPASMAVMEGDLVKKERDLVQEEEQLMEEKKKKKDDKKK
KEAAQKKATEQKIKVPEQIKPSVSQPQPANSNNGTSTATSTNNNAKRATANNQQPQQQQQQQQPQQQQPQQQPQPQPQQQQPQQQPQALP
RYPREVPPRFRHQEHKQLLKRGQHFPVIAANLGSAVKVLNSQSESSALTNQQPQNNGEVQNSKNQSDINHSTSGSHYENSQRGPVSSTSD
SSTNCKNAVVSDLSEKEAWPSAPGSDPELASECMDADSASSSESERNITIMASGNTGGEKDGLRNSTGLGSQNKFVVGSSSNNVGHGSST
GPWGFSHGAIISTCQVSVDAPESKSESSNNRMNAWGTVSSSSNGGLNPSTLNSASNHGAWPVLENNGLALKGPVGSGSSGINIQCSTIGQ
MPNNQSINSKVSGGSTHGTWGSLQETCESEVSGTQKVSFSGQPQNITTEMTGPNNTTNFMTSSLPNSGSVQNNELPSSNTGAWRVSTMNH
PQMQAPSGMNGTSLSHLSNGESKSGGSYGTTWGAYGSNYSGDKCSGPNGQANGDTVNATLMQPGVNGPMGTNFQVNTNKGGGVWESGAAN
SQSTSWGSGNGANSGGSRRGWGTPAQNTGTNLPSVEWNKLPSNQHSNDSANGNGKTFTNGWKSTEEEDQGSATSQTNEQSSVWAKTGGTV
ESDGSTESTGRLEEKGTGESQSRDRRKIDQHTLLQSIVNRTDLDPRVLSNSGWGQTPIKQNTAWDTETSPRGERKTDNGTEAWGSSATQT
FNSGACIDKTSPNGNDTSSVSGWGDPKPALRWGDSKGSNCQGGWEDDSAATGMVKSNQWGNCKEEKAAWNDSQKNKQGWGDGQKSSQGWS
VSASDNWGETSRNNHWGEANKKSSSGGSDSDRSVSGWNELGKTSSFTWGNNINPNNSSGWDESSKPTPSQGWGDPPKSNQSLGWGDSSKP
VSSPDWNKQQDIVGSWGIPPATGKPPGTGWLGGPIPAPAKEEEPTGWEEPSPESIRRKMEIDDGTSAWGDPSKYNYKNVNMWNKNVPNGN
SRSDQQAQVHQLLTPASAISNKEASSGSGWGEPWGEPSTPATTVDNGTSAWGKPIDSGPSWGEPIAAASSTSTWGSSSVGPQALSKSGPK
SMQDGWCGDDMPLPGNRPTGWEEEEDVEIGMWNSNSSQELNSSLNWPPYTKKMSSKGLSGKKRRRERGMMKGGNKQEEAWINPFVKQFSN
ISFSRDSPEENVQSNKMDLSGGMLQDKRMEIDKHSLNIGDYNRTVGKGPGSRPQISKESSMERNPYFDKNGNPSMFGVGNTAAQPRGMQQ
PPAQPLSSSQPNLRAQVPPPLLSPQVPVSLLKYAPNNGGLNPLFGPQQVAMLNQLSQLNQLSQISQLQRLLAQQQRAQSQRSVPSGNRPQ
QDQQGRPLSVQQQMMQQSRQLDPNLLVKQQTPPSQQQPLHQPAMKSFLDNVMPHTTPELQKGPSPINAFSNFPIGLNSNLNVNMDMNSIK
EPQSRLRKWTTVDSISVNTSLDQNSSKHGAISSGFRLEESPFVPYDFMNSSTSPASPPGSIGDGWPRAKSPNGSSSVNWPPEFRPGEPWK
GYPNIDPETDPYVTPGSVINNLSINTVREVDHLRDRNSGSSSSLNTTLPSTSAWSSIRASNYNVPLSSTAQSTSARNSDSKLTWSPGSVT
NTSLAHELWKVPLPPKNITAPSRPPPGLTGQKPPLSTWDNSPLRIGGGWGNSDARYTPGSSWGESSSGRITNWLVLKNLTPQIDGSTLRT
LCMQHGPLITFHLNLPHGNALVRYSSKEEVVKAQKSLHMCVLGNTTILAEFASEEEISRFFAQSQSLTPSPGWQSLGSSQSRLGSLDCSH

--------------------------------------------------------------
>5962_5962_2_ARHGAP17-TNRC6A_ARHGAP17_chr16_24953308_ENST00000303665_TNRC6A_chr16_24762047_ENST00000315183_length(transcript)=9663nt_BP=1560nt
GTAGTAGCTGCCAGGCTGTCCCCCGCCCTGCCCGGCCCGAGCCCCGCGGGCCGCCGCCGCCACCGCCGCCATGAAGAAGCAGTTCAACCG
CATGAAGCAGCTGGCTAACCAGACCGTGGGCAGAGCTGAGAAAACAGAAGTCCTTAGTGAAGATCTATTACAGATTGAGAGACGCCTGGA
CACGGTGCGGTCAATATGCCACCATTCCCATAAGCGCTTGGTGGCATGTTTCCAGGGCCAGCATGGCACCGATGCCGAGAGGAGACACAA
AAAACTGCCTCTGACAGCTCTTGCTCAAAATATGCAAGAAGCATCGACTCAGCTGGAAGACTCTCTCCTGGGGAAGATGCTGGAGACGTG
TGGAGATGCTGAGAATCAGCTGGCTCTCGAGCTCTCCCAGCACGAAGTCTTTGTTGAGAAGGAGATCGTGGACCCTCTGTACGGCATAGC
TGAGGTGGAGATTCCCAACATCCAGAAGCAGAGGAAGCAGCTTGCAAGATTGGTGTTAGACTGGGATTCAGTCAGAGCCAGGTGGAACCA
AGCTCACAAATCCTCAGGAACCAACTTTCAGGGGCTTCCATCAAAAATAGATACTCTAAAGGAAGAGATGGATGAAGCTGGAAATAAAGT
AGAACAGTGCAAGGATCAACTTGCAGCAGACATGTACAACTTTATGGCCAAAGAAGGGGAGTATGGCAAATTCTTTGTTACGTTATTAGA
AGCCCAAGCAGATTACCATAGAAAAGCATTAGCAGTCTTAGAAAAGACCCTCCCCGAAATGCGAGCCCATCAAGATAAGTGGGCGGAAAA
ACCAGCCTTTGGGACTCCCCTAGAAGAACACCTGAAGAGGAGCGGGCGCGAGATTGCGCTGCCCATTGAAGCCTGTGTCATGCTGCTTCT
GGAGACAGGCATGAAGGAGGAGGGCCTTTTCCGAATTGGGGCTGGGGCCTCCAAGTTAAAGAAGCTGAAAGCTGCTTTGGACTGTTCTAC
TTCTCACCTGGATGAGTTCTATTCAGACCCCCATGCTGTAGCAGGTGCTTTAAAATCCTATTTACGGGAATTGCCTGAACCTTTGATGAC
TTTTAATCTGTATGAAGAATGGACACAAGTTGCAAGTGTGCAGGATCAAGACAAAAAACTTCAAGACTTGTGGAGAACATGTCAGAAGTT
GCCACCACAAAATTTTGTTAACTTTAGATATTTGATCAAGTTCCTTGCAAAGCTTGCTCAGACCAGCGATGTGAATAAAATGACTCCCAG
CAACATTGCGATTGTGTTAGGCCCTAACTTGTTATGGGCCAGAAATGAAGGAACACTTGCTGAAATGGCAGCAGCCACATCCGTCCATGT
GGTTGCAGTGATTGAACCCATCATTCAGCATGCCGACTGGTTCTTCCCTGAAGAGGTGGAATTTAATGTATCAGAAGCATTTGTACCTCT
CACCACCCCGAGTTCTAATCACTCATTCCACACTGGAAACGACTCTGACTCGGGGACCCTGGAGAGGAAGCGGCCTGCTAGCATGGCGGT
GATGGAAGGAGACTTGGTGAAGAAGGAAAGGGATTTAGTGCAAGAAGAAGAACAGTTGATGGAAGAAAAGAAAAAGAAAAAAGACGACAA
GAAAAAGAAGGAAGCTGCTCAAAAGAAGGCCACTGAACAAAAAATCAAAGTGCCAGAACAGATAAAGCCCAGTGTAAGCCAGCCTCAGCC
TGCCAACTCTAATAACGGCACTTCCACAGCAACCAGCACTAATAATAATGCCAAGCGAGCTACAGCCAACAATCAGCAGCCACAGCAGCA
GCAGCAACAGCAGCAGCCGCAGCAGCAGCAGCCACAGCAGCAGCCACAGCCGCAGCCGCAGCAGCAGCAGCCACAGCAGCAGCCACAGGC
CTTGCCTCGGTATCCTCGTGAAGTACCTCCACGATTTCGCCACCAGGAACACAAACAGCTTCTAAAGAGGGGTCAGCATTTTCCTGTTAT
AGCAGCAAACCTTGGATCTGCTGTTAAGGTGTTAAACAGCCAGTCAGAAAGCAGTGCTTTAACAAATCAACAGCCACAAAATAACGGAGA
GGTGCAGAACAGCAAAAACCAGTCAGATATAAACCACAGTACTTCAGGATCCCATTATGAAAATTCCCAGCGGGGACCTGTGTCTTCTAC
AAGTGATTCTAGCACAAACTGTAAGAATGCTGTTGTAAGTGACTTGTCGGAAAAAGAAGCATGGCCCTCAGCCCCTGGCAGTGATCCGGA
GTTGGCTTCAGAATGTATGGATGCTGATTCTGCCTCCAGTTCTGAATCAGAGAGAAACATCACTATCATGGCTTCAGGGAACACAGGTGG
TGAAAAAGATGGCCTTCGGAATAGCACTGGACTTGGTTCCCAAAACAAGTTTGTAGTTGGTAGCAGCAGCAATAATGTGGGCCATGGAAG
TAGTACTGGGCCATGGGGTTTTTCCCATGGAGCCATAATAAGCACATGTCAGGTCTCTGTGGATGCTCCTGAAAGCAAATCTGAAAGTAG
CAACAATAGAATGAATGCTTGGGGCACTGTAAGTTCTTCATCAAATGGAGGGTTAAATCCAAGCACTTTGAATTCAGCTAGCAACCATGG
TGCCTGGCCAGTATTAGAGAACAATGGACTTGCCCTAAAAGGGCCTGTAGGGAGTGGTAGTTCTGGCATTAATATTCAGTGCAGTACTAT
AGGCCAGATGCCTAACAATCAGAGTATTAACTCTAAAGTGAGTGGTGGTTCTACCCATGGTACCTGGGGAAGCCTTCAGGAAACTTGTGA
ATCTGAAGTAAGTGGTACACAGAAGGTTTCATTCAGTGGTCAACCTCAAAATATTACCACTGAAATGACTGGACCAAATAACACTACTAA
CTTTATGACCTCTAGTTTACCAAACTCCGGTTCAGTGCAGAATAATGAGCTGCCTAGTAGTAACACAGGGGCCTGGCGTGTGAGCACAAT
GAATCATCCTCAGATGCAGGCTCCATCAGGTATGAATGGCACTTCCCTTTCTCACCTTAGCAATGGAGAGTCAAAAAGTGGAGGCTCTTA
TGGTACTACATGGGGTGCCTATGGTTCTAATTACTCTGGAGACAAATGTTCAGGCCCTAATGGCCAAGCTAATGGTGACACTGTGAATGC
AACTCTAATGCAGCCTGGCGTAAATGGTCCTATGGGCACTAACTTTCAAGTTAACACAAACAAAGGAGGTGGTGTGTGGGAATCTGGTGC
AGCAAACTCCCAGAGTACATCATGGGGAAGTGGAAATGGCGCAAATTCTGGAGGAAGTCGAAGAGGATGGGGAACCCCTGCACAAAACAC
TGGCACTAATTTACCCAGCGTTGAGTGGAACAAACTGCCTAGCAATCAGCATTCCAATGATAGTGCAAATGGCAATGGTAAGACGTTTAC
AAATGGATGGAAATCTACTGAGGAAGAGGATCAGGGTTCTGCCACATCTCAGACAAATGAGCAAAGCAGTGTGTGGGCCAAAACAGGAGG
TACAGTGGAGAGCGATGGTAGTACAGAAAGCACTGGACGCCTTGAGGAAAAAGGAACTGGGGAAAGTCAGAGTAGAGACAGAAGAAAAAT
TGATCAGCACACATTACTCCAAAGCATTGTAAACAGAACTGACTTAGATCCACGTGTCCTGTCCAACTCTGGTTGGGGACAGACTCCTAT
TAAGCAGAATACTGCCTGGGATACAGAAACATCACCTAGAGGGGAACGAAAGACTGACAATGGGACAGAGGCCTGGGGAAGCTCTGCAAC
ACAGACTTTTAACTCAGGGGCATGTATAGATAAGACTAGCCCTAATGGTAATGATACCTCATCTGTATCAGGGTGGGGCGATCCCAAACC
TGCTCTGAGGTGGGGAGATTCCAAAGGCTCAAACTGCCAGGGGGGGTGGGAAGATGATTCTGCTGCTACAGGAATGGTCAAGAGCAATCA
GTGGGGGAATTGCAAAGAGGAGAAGGCTGCATGGAATGACTCGCAAAAGAATAAACAGGGATGGGGTGATGGACAAAAATCAAGCCAAGG
GTGGTCTGTTTCTGCCAGTGATAACTGGGGAGAAACTTCAAGGAATAACCATTGGGGTGAGGCCAATAAGAAATCCAGCTCAGGAGGTAG
TGACAGTGACAGGTCCGTTTCCGGTTGGAACGAACTTGGTAAAACTAGTTCTTTCACTTGGGGAAACAACATAAATCCAAATAATTCATC
AGGATGGGATGAATCTTCTAAACCTACTCCTTCCCAGGGATGGGGAGACCCTCCAAAGTCTAATCAGTCTCTAGGTTGGGGAGATTCGTC
AAAGCCAGTCAGCTCTCCAGACTGGAACAAGCAACAAGACATTGTTGGATCTTGGGGAATCCCACCAGCTACAGGCAAACCTCCTGGTAC
AGGCTGGCTGGGGGGACCTATACCAGCCCCAGCAAAAGAAGAAGAACCCACAGGCTGGGAGGAACCATCCCCAGAATCTATACGTCGCAA
AATGGAGATTGATGATGGAACTTCAGCTTGGGGAGATCCAAGCAAATACAACTACAAAAATGTGAACATGTGGAACAAAAACGTCCCAAA
TGGCAACAGCCGTTCAGACCAGCAAGCACAGGTACATCAGCTGCTAACGCCTGCAAGTGCCATCTCAAACAAAGAGGCAAGCAGTGGCTC
TGGCTGGGGTGAGCCCTGGGGGGAGCCTTCTACTCCAGCCACAACTGTGGATAATGGTACTTCAGCATGGGGTAAGCCCATAGACAGTGG
TCCCAGCTGGGGGGAACCCATTGCTGCGGCATCCAGCACATCCACGTGGGGCTCCAGCTCTGTTGGTCCACAAGCATTAAGCAAATCTGG
GCCAAAATCTATGCAAGATGGCTGGTGTGGTGATGATATGCCATTGCCTGGAAATCGCCCCACTGGCTGGGAAGAGGAAGAGGATGTGGA
GATTGGAATGTGGAATAGTAATTCATCTCAAGAGCTTAACTCATCTTTAAATTGGCCACCATATACAAAGAAAATGTCATCGAAGGGTCT
GAGTGGCAAAAAAAGGAGAAGGGAAAGGGGAATGATGAAAGGTGGAAACAAACAAGAAGAAGCGTGGATAAATCCATTTGTTAAACAGTT
TTCAAACATCAGTTTTTCGAGAGACTCACCAGAGGAAAATGTACAAAGCAATAAGATGGACCTTTCTGGAGGAATGTTACAAGACAAACG
AATGGAGATAGATAAACATAGCCTAAATATTGGTGATTACAATCGAACGGTCGGGAAAGGCCCTGGTTCTCGGCCTCAGATTTCCAAAGA
GTCTTCCATGGAGCGCAATCCTTATTTTGATAAGAATGGCAATCCCAGTATGTTTGGTGTTGGAAACACAGCAGCACAACCCCGGGGCAT
GCAGCAGCCTCCAGCACAACCTCTTAGTTCATCTCAGCCTAATCTCCGTGCTCAAGTGCCTCCTCCATTACTCTCCCCTCAGGTTCCAGT
TTCATTGCTGAAGTATGCACCAAACAACGGTGGCCTGAATCCACTCTTTGGCCCTCAACAGGTAGCCATGCTGAACCAGCTATCCCAGCT
AAACCAGCTTTCTCAGATCTCCCAGTTACAGCGATTGTTAGCGCAGCAGCAAAGGGCGCAGAGTCAGAGAAGCGTGCCTTCTGGGAACCG
GCCGCAGCAAGACCAGCAGGGTCGACCTCTTAGTGTGCAGCAGCAAATGATGCAACAATCTCGTCAACTTGATCCAAACCTGTTGGTGAA
GCAGCAGACTCCACCATCTCAGCAGCAGCCACTCCATCAGCCAGCCATGAAGTCTTTCCTTGACAATGTCATGCCCCACACTACACCTGA
GCTGCAAAAAGGGCCATCACCAATAAATGCTTTCAGCAACTTCCCTATAGGCTTGAACTCAAACTTGAATGTAAATATGGATATGAACAG
TATTAAAGAGCCACAGTCAAGACTAAGGAAGTGGACGACAGTGGACAGCATTTCTGTGAACACATCTTTGGATCAAAACTCCAGCAAACA
TGGTGCTATTTCAAGTGGTTTCAGGCTGGAAGAGTCTCCATTTGTTCCCTATGACTTTATGAACAGCAGTACTTCACCAGCCAGTCCTCC
AGGTTCAATAGGAGATGGCTGGCCACGTGCCAAATCGCCTAACGGCTCTAGCAGTGTTAATTGGCCACCAGAATTTCGTCCTGGTGAGCC
ATGGAAAGGTTATCCAAACATTGACCCTGAAACTGACCCTTACGTCACTCCTGGCAGTGTCATAAACAATCTTTCAATTAATACTGTGCG
GGAAGTTGACCACCTCAGGGACAGGAACAGTGGGTCATCCTCATCCTTGAACACCACGCTGCCTTCAACTAGTGCCTGGTCATCCATTCG
TGCCTCCAACTACAACGTTCCCCTCAGCAGTACAGCACAAAGCACTTCAGCCAGAAATAGTGATTCCAAATTGACATGGTCTCCTGGTTC
AGTTACAAACACCTCTCTGGCTCATGAGCTGTGGAAGGTCCCTTTGCCACCTAAAAACATCACTGCTCCGTCCCGCCCACCTCCGGGACT
GACTGGTCAGAAGCCACCCTTGTCTACGTGGGATAATTCTCCCCTTCGTATAGGTGGAGGATGGGGAAATTCTGACGCCAGATATACCCC
AGGTTCCAGCTGGGGTGAGAGCAGCTCAGGGAGAATAACAAATTGGCTTGTTCTAAAAAACCTTACACCTCAGATCGATGGCTCAACTCT
GCGCACTCTGTGCATGCAGCACGGCCCGCTGATCACATTCCACCTGAACCTCCCTCACGGAAATGCTCTGGTCCGCTACAGTTCAAAAGA
AGAGGTAGTGAAGGCACAAAAGTCTCTGCACATGTGTGTACTGGGGAACACTACTATTCTTGCTGAGTTTGCCAGTGAAGAGGAGATCAG
TCGTTTCTTTGCACAAAGCCAGTCTCTGACCCCTTCTCCCGGCTGGCAGTCTCTCGGGTCCAGCCAGAGCCGGCTGGGCTCCCTCGACTG
TTCCCACTCATTCTCCAGCCGGACCGATCTCAATCACTGGAATGGTGCTGGGCTGTCGGGAACTAACTGTGGAGACCTTCACGGCACTTC
ACTCTGGGGGACCCCGCATTATTCCACAAGCCTGTGGGGTCCCCCAAGCAGCAGCGACCCCCGAGGAATTAGCAGCCCATCTCCCATTAA
CGCTTTTCTTTCTGTTGACCACCTGGGTGGGGGTGGAGAGTCCATGTAACAGTGTAGATGCAGACTCACCGACCGGGACCTCAGACGCGA
GGGAAAGGAGCACTAAGTGGGGCTCGCCGCCTGCAGCCAGGGGCCGCCTGTGGGAACAGCTATTCTCTGCACATTTTCCACTTTGTTTTC
CCCAAAACATATCAGTTTGAATACTTGAATCATGCAGGCCAATATTATAATGTGAAAAGGTATCTACTCTATTTACACTCCCAAATAGCG
CCATACATGCTAAACCGTAGAGAATGAGCTCGCTTGTGTCTATTCATCATGTTTAGCCTTTGGATTCTTTTTTTTTTTTTCCTTCTATTC
CTCCCCAACCCCCCCCCCCGCCCCTTTTTTTCTCTCTTGCAAAACCATTTTTTGGGCTGATAACGTATGAGCTTTTCCCTTTGCACTGAA
TGATGTTCTCTCCGTCTCATCGGCAGTATGGGGGGCAGCTGTCCCAGTGTCAATGTTTACTCAAGGGTGTTCTTAGGAGGCGTGCGCTCT
CTACTATGCCTTGATGTTGCCTACCTTATTGTGGTATCGTGGAGTTTAAAAGATCAAGTTAGGATGCTGACTTAGGATTATTAATGAAAG
TGTTGCACCAGTTTTTTCATGTTGTAAAACTAAAGAATTTCGCTCTGCAGTTTGAAAAACTGTGGCCACAGCTGTGACTTGCAGCCCACC
TGCCACCCAGGACGGGCCCTGCACTTTGAATAGGCTTTCCATTTTGTTTTGGAGGTTCTCACTTTGAACCTTCTTGTTTACAGATTTTTT
TGTTTGTTTTTTGAGAAAAAAAAATGTTTACTCTTCCATCATTTAAAAAAAATGTAAAAGACAAAAAAAAAATGGAGGATGATTTAAAAG
ATGCTTTCTATCTCTGGGAAAAAGGAGCAGCATTTGGCCATGTTCTTTTGTTTTTCTATTCCTGTCCCAAATCAAAGAGCATGGTTCTCA
GGAAAACCAGTTCCCCAGTTTAAAAAAAAAAAAAAAAATTCCTTGTAGTTTCTTAGAGGAAAAAAAGAAAAACCCCAACTTTTAGCACTG
ATACTACATATTGCTCTGTTAAAGAATTTTCTCTGCCAAAAAAAAAGAAAAAACAAAAAAACGCTTAAAGCTGGAGTTTGACATTCTGCT
TTCAGATGCTGTCTTTTTATTAGTGAGTGATGATGGTTTGCTAATAATCAATAGGTAATAATTTTTTGTAATCCCATCAAGTGGCTCCAT
ATGTTTCTGCTCTCTCGTGACTGTGTTAATGTTTAACTGTTGTACCTTAAAGCCGAAATCAGTAACTATGCATACTGTAACCAAGGTATT
GGGCTTACAGAGTTGTTTGTTGTATAAAGAAAATTTTAAATGTTGTTGCAAACTAACGAGTTACACCATTTTAAACTTTCTTTCCTCCCC
CCTTTTTTTGCCCACAAATGGTATTATAATGCTTGCTTAGTCAAAGAAGAGAGACTAAACAAGGGTAAAAATTTTAACAGTACAGAATTT
GCCATCATATCATTGCCTTGATTCTAACTGTTTGTGTCCTAAGATGCAAAAGAAGTCAGTGGCTTTTAACTGTTTACAAATAGAATGTGA
TTGTAAAATGTACAGTTTGGTTGTGTTTGAATTATGAAATTTCTTCAGATATAATAAACCATGACTTTTTGGCTGCTCAACATTAATTGT
CTCCTTTTTGTGAATTTATTTGTAGGCTCTTTTTTATAATGAAAGTTTCAAAGTTGCTATGTATGAGGGTTCTCATAGAGCAACCGATTA
AAAATCTAAGCAAATATTTGAACATTTTATCTGAACTCATCACAATTTCACCCTGAAATAATGTGAGAACAATGGGAAACTGTAGCTTGC
TCCTTCCCACCCTCTCTGAGCATCTTTGGGATCTTGTTGCTCAAAACTCTTCTGTGACTTCATCTTCCCCACCATTTGTGCCCATCTCAA
GCCTCAGCAAGAAACCATGTGGAACATGAAGCTTAATGACTTGACAGTGTACTAGTGTTAAACTCTCATACCTCTGTTACAAAGCGAGAA
ACGCCACACCCGGACTGGCCTTTTCTTCCCCCTTCACGGCCCTCGCTTCTCCCTGCAGGAGCTCGGGGGCGAAACCTGTGTATGGATTTC
AGTGTATGACTTCAGATCATGCTCCAACTTGCCAGGTGTGAGCTAATGTTGTCGGACACCTTACTATAAGCAAATGTTATTCAGTGCGTT
CAATGTATATTGACTTCCATACTGGTTTTTCCAAAAACCAAAGGTAGCTTTGAAAAACCATGTCTGGAAATGTTTGGAGCGTTAAGCTGA
TTGACCTTCTGACCTTGGGGCTTTGAGTAGTATATAATTCATAACTGCGTTAATTGTATTGTTAAAGTGTTTGGGAGTTTTTTGCGCTTG

>5962_5962_2_ARHGAP17-TNRC6A_ARHGAP17_chr16_24953308_ENST00000303665_TNRC6A_chr16_24762047_ENST00000315183_length(amino acids)=2413AA_BP=517
MPGCPPPCPARAPRAAAATAAMKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICHHSHKRLVACFQGQHGTDAERRHKKL
PLTALAQNMQEASTQLEDSLLGKMLETCGDAENQLALELSQHEVFVEKEIVDPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAH
KSSGTNFQGLPSKIDTLKEEMDEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKTLPEMRAHQDKWAEKPA
FGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFN
LYEEWTQVASVQDQDKKLQDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMAAATSVHVVA
VIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSSNHSFHTGNDSDSGTLERKRPASMAVMEGDLVKKERDLVQEEEQLMEEKKKKKDDKKK
KEAAQKKATEQKIKVPEQIKPSVSQPQPANSNNGTSTATSTNNNAKRATANNQQPQQQQQQQQPQQQQPQQQPQPQPQQQQPQQQPQALP
RYPREVPPRFRHQEHKQLLKRGQHFPVIAANLGSAVKVLNSQSESSALTNQQPQNNGEVQNSKNQSDINHSTSGSHYENSQRGPVSSTSD
SSTNCKNAVVSDLSEKEAWPSAPGSDPELASECMDADSASSSESERNITIMASGNTGGEKDGLRNSTGLGSQNKFVVGSSSNNVGHGSST
GPWGFSHGAIISTCQVSVDAPESKSESSNNRMNAWGTVSSSSNGGLNPSTLNSASNHGAWPVLENNGLALKGPVGSGSSGINIQCSTIGQ
MPNNQSINSKVSGGSTHGTWGSLQETCESEVSGTQKVSFSGQPQNITTEMTGPNNTTNFMTSSLPNSGSVQNNELPSSNTGAWRVSTMNH
PQMQAPSGMNGTSLSHLSNGESKSGGSYGTTWGAYGSNYSGDKCSGPNGQANGDTVNATLMQPGVNGPMGTNFQVNTNKGGGVWESGAAN
SQSTSWGSGNGANSGGSRRGWGTPAQNTGTNLPSVEWNKLPSNQHSNDSANGNGKTFTNGWKSTEEEDQGSATSQTNEQSSVWAKTGGTV
ESDGSTESTGRLEEKGTGESQSRDRRKIDQHTLLQSIVNRTDLDPRVLSNSGWGQTPIKQNTAWDTETSPRGERKTDNGTEAWGSSATQT
FNSGACIDKTSPNGNDTSSVSGWGDPKPALRWGDSKGSNCQGGWEDDSAATGMVKSNQWGNCKEEKAAWNDSQKNKQGWGDGQKSSQGWS
VSASDNWGETSRNNHWGEANKKSSSGGSDSDRSVSGWNELGKTSSFTWGNNINPNNSSGWDESSKPTPSQGWGDPPKSNQSLGWGDSSKP
VSSPDWNKQQDIVGSWGIPPATGKPPGTGWLGGPIPAPAKEEEPTGWEEPSPESIRRKMEIDDGTSAWGDPSKYNYKNVNMWNKNVPNGN
SRSDQQAQVHQLLTPASAISNKEASSGSGWGEPWGEPSTPATTVDNGTSAWGKPIDSGPSWGEPIAAASSTSTWGSSSVGPQALSKSGPK
SMQDGWCGDDMPLPGNRPTGWEEEEDVEIGMWNSNSSQELNSSLNWPPYTKKMSSKGLSGKKRRRERGMMKGGNKQEEAWINPFVKQFSN
ISFSRDSPEENVQSNKMDLSGGMLQDKRMEIDKHSLNIGDYNRTVGKGPGSRPQISKESSMERNPYFDKNGNPSMFGVGNTAAQPRGMQQ
PPAQPLSSSQPNLRAQVPPPLLSPQVPVSLLKYAPNNGGLNPLFGPQQVAMLNQLSQLNQLSQISQLQRLLAQQQRAQSQRSVPSGNRPQ
QDQQGRPLSVQQQMMQQSRQLDPNLLVKQQTPPSQQQPLHQPAMKSFLDNVMPHTTPELQKGPSPINAFSNFPIGLNSNLNVNMDMNSIK
EPQSRLRKWTTVDSISVNTSLDQNSSKHGAISSGFRLEESPFVPYDFMNSSTSPASPPGSIGDGWPRAKSPNGSSSVNWPPEFRPGEPWK
GYPNIDPETDPYVTPGSVINNLSINTVREVDHLRDRNSGSSSSLNTTLPSTSAWSSIRASNYNVPLSSTAQSTSARNSDSKLTWSPGSVT
NTSLAHELWKVPLPPKNITAPSRPPPGLTGQKPPLSTWDNSPLRIGGGWGNSDARYTPGSSWGESSSGRITNWLVLKNLTPQIDGSTLRT
LCMQHGPLITFHLNLPHGNALVRYSSKEEVVKAQKSLHMCVLGNTTILAEFASEEEISRFFAQSQSLTPSPGWQSLGSSQSRLGSLDCSH

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ARHGAP17-TNRC6A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneTNRC6Achr16:24953308chr16:24762047ENST000003151831241_93217.6666666666666681914.0argonaute family proteins
TgeneTNRC6Achr16:24953308chr16:24762047ENST000003957991251_93217.6666666666666681963.0argonaute family proteins


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ARHGAP17-TNRC6A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ARHGAP17-TNRC6A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource