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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NOP2-SNHG14 (FusionGDB2 ID:59633)

Fusion Gene Summary for NOP2-SNHG14

check button Fusion gene summary
Fusion gene informationFusion gene name: NOP2-SNHG14
Fusion gene ID: 59633
HgeneTgene
Gene symbol

NOP2

SNHG14

Gene ID

4839

104472715

Gene nameNOP2 nucleolar proteinsmall nucleolar RNA host gene 14
SynonymsNOL1|NOP120|NSUN1|p120115HG|IC-SNURF-SNRPN|LNCAT|NCRNA00214|U-UBE3A-ATS|UBE3A-AS|UBE3A-AS1|UBE3A-ATS|UBE3AATS
Cytomap

12p13.31

15q11.2

Type of geneprotein-codingncRNA
Descriptionprobable 28S rRNA (cytosine(4447)-C(5))-methyltransferaseNOL1/NOP2/Sun domain family, member 1NOP2 nucleolar protein homolognucleolar protein 1, 120kDanucleolar protein 2 homologproliferating-cell nucleolar antigen p120proliferation-associated nucleUBE3A antisense RNA 1 (non-protein coding)UBE3A antisense transcriptlarge noncoding antisense transcriptsmall nucleolar RNA host gene 14 (non-protein coding)
Modification date2020031320200303
UniProtAcc

P46087

.
Ensembl transtripts involved in fusion geneENST00000322166, ENST00000382421, 
ENST00000399466, ENST00000537442, 
ENST00000540228, ENST00000541778, 
ENST00000542015, ENST00000545200, 
ENST00000545915, 
ENST00000363358, 
ENST00000365067, ENST00000365306, 
ENST00000384430, ENST00000384733, 
ENST00000390982, ENST00000414175, 
ENST00000424208, ENST00000424333, 
ENST00000441592, ENST00000450809, 
ENST00000452731, ENST00000453082, 
ENST00000456576, ENST00000459433, 
ENST00000516123, ENST00000546682, 
ENST00000547292, ENST00000549804, 
ENST00000551077, ENST00000551361, 
ENST00000551631, ENST00000551938, 
ENST00000553108, ENST00000553134, 
ENST00000553149, ENST00000554726, 
ENST00000580438, 
Fusion gene scores* DoF score4 X 6 X 5=12016 X 19 X 4=1216
# samples 620
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(20/1216*10)=-2.60407132366886
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NOP2 [Title/Abstract] AND SNHG14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNOP2(6666239)-SNHG14(25213171), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNOP2

GO:0008284

positive regulation of cell proliferation

1394192


check buttonFusion gene breakpoints across NOP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SNHG14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF769740NOP2chr12

6666239

-SNHG14chr15

25213171

-


Top

Fusion Gene ORF analysis for NOP2-SNHG14

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000322166ENST00000363358NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000365067NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000365306NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000384430NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000384733NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000390982NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000414175NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000424208NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000424333NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000441592NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000450809NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000452731NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000453082NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000456576NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000459433NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000516123NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000546682NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000547292NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000549804NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000551077NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000551361NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000551631NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000551938NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000553108NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000553134NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000553149NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000554726NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000322166ENST00000580438NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000363358NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000365067NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000365306NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000384430NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000384733NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000390982NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000414175NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000424208NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000424333NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000441592NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000450809NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000452731NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000453082NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000456576NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000459433NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000516123NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000546682NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000547292NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000549804NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000551077NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000551361NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000551631NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000551938NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000553108NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000553134NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000553149NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000554726NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000382421ENST00000580438NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000363358NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000365067NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000365306NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000384430NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000384733NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000390982NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000414175NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000424208NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000424333NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000441592NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000450809NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000452731NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000453082NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000456576NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000459433NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000516123NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000546682NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000547292NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000549804NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000551077NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000551361NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000551631NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000551938NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000553108NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000553134NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000553149NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000554726NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000399466ENST00000580438NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000363358NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000365067NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000365306NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000384430NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000384733NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000390982NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000414175NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000424208NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000424333NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000441592NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000450809NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000452731NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000453082NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000456576NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000459433NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000516123NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000546682NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000547292NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000549804NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000551077NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000551361NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000551631NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000551938NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000553108NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000553134NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000553149NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000554726NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000537442ENST00000580438NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000363358NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000365067NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000365306NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000384430NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000384733NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000390982NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000414175NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000424208NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000424333NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000441592NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000450809NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000452731NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000453082NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000456576NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000459433NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000516123NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000546682NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000547292NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000549804NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000551077NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000551361NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000551631NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000551938NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000553108NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000553134NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000553149NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000554726NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000540228ENST00000580438NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000363358NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000365067NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000365306NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000384430NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000384733NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000390982NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000414175NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000424208NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000424333NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000441592NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000450809NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000452731NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000453082NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000456576NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000459433NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000516123NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000546682NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000547292NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000549804NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000551077NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000551361NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000551631NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000551938NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000553108NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000553134NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000553149NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000554726NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000541778ENST00000580438NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000363358NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000365067NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000365306NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000384430NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000384733NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000390982NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000414175NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000424208NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000424333NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000441592NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000450809NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000452731NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000453082NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000456576NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000459433NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000516123NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000546682NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000547292NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000549804NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000551077NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000551361NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000551631NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000551938NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000553108NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000553134NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000553149NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000554726NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000542015ENST00000580438NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000363358NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000365067NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000365306NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000384430NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000384733NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000390982NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000414175NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000424208NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000424333NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000441592NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000450809NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000452731NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000453082NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000456576NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000459433NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000516123NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000546682NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000547292NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000549804NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000551077NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000551361NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000551631NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000551938NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000553108NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000553134NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000553149NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000554726NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545200ENST00000580438NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000363358NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000365067NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000365306NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000384430NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000384733NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000390982NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000414175NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000424208NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000424333NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000441592NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000450809NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000452731NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000453082NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000456576NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000459433NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000516123NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000546682NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000547292NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000549804NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000551077NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000551361NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000551631NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000551938NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000553108NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000553134NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000553149NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000554726NOP2chr12

6666239

-SNHG14chr15

25213171

-
intron-intronENST00000545915ENST00000580438NOP2chr12

6666239

-SNHG14chr15

25213171

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NOP2-SNHG14


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NOP2-SNHG14


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:6666239/:25213171)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NOP2

P46087

.
FUNCTION: Involved in ribosomal large subunit assembly (PubMed:24120868). S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable). {ECO:0000269|PubMed:24120868, ECO:0000305, ECO:0000305|PubMed:23913415}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NOP2-SNHG14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NOP2-SNHG14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NOP2-SNHG14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NOP2-SNHG14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource