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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:NOP58-BMPR2 (FusionGDB2 ID:59651) |
Fusion Gene Summary for NOP58-BMPR2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NOP58-BMPR2 | Fusion gene ID: 59651 | Hgene | Tgene | Gene symbol | NOP58 | BMPR2 | Gene ID | 51602 | 659 |
| Gene name | NOP58 ribonucleoprotein | bone morphogenetic protein receptor type 2 | |
| Synonyms | HSPC120|NOP5|NOP5/NOP58 | BMPR-II|BMPR3|BMR2|BRK-3|POVD1|PPH1|T-ALK | |
| Cytomap | 2q33.1 | 2q33.1-q33.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nucleolar protein 58NOP58 ribonucleoprotein homolognucleolar protein 5nucleolar protein NOP5/NOP58 | bone morphogenetic protein receptor type-2BMP type II receptorBMP type-2 receptorbone morphogenetic protein receptor type IIbone morphogenetic protein receptor, type II (serine/threonine kinase)type II activin receptor-like kinasetype II receptor fo | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9Y2X3 | Q13873 | |
| Ensembl transtripts involved in fusion gene | ENST00000264279, ENST00000467734, | ENST00000479069, ENST00000374574, ENST00000374580, | |
| Fusion gene scores | * DoF score | 9 X 9 X 6=486 | 10 X 10 X 2=200 |
| # samples | 10 | 10 | |
| ** MAII score | log2(10/486*10)=-2.28095631383106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/200*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NOP58 [Title/Abstract] AND BMPR2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | BMPR2(203242273)-NOP58(203139836), # samples:2 NOP58(203152447)-BMPR2(203329532), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | BMPR2-NOP58 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. BMPR2-NOP58 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. BMPR2-NOP58 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. BMPR2-NOP58 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | BMPR2 | GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway | 12045205 |
| Tgene | BMPR2 | GO:0010634 | positive regulation of epithelial cell migration | 12819188 |
| Tgene | BMPR2 | GO:0030308 | negative regulation of cell growth | 12819188 |
| Tgene | BMPR2 | GO:0030509 | BMP signaling pathway | 18436533 |
| Fusion gene breakpoints across NOP58 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across BMPR2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUSC | TCGA-22-1016-01A | NOP58 | chr2 | 203152447 | + | BMPR2 | chr2 | 203329532 | + |
| ChimerDB4 | LUSC | TCGA-22-1016 | NOP58 | chr2 | 203152447 | + | BMPR2 | chr2 | 203329532 | + |
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Fusion Gene ORF analysis for NOP58-BMPR2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000264279 | ENST00000479069 | NOP58 | chr2 | 203152447 | + | BMPR2 | chr2 | 203329532 | + |
| In-frame | ENST00000264279 | ENST00000374574 | NOP58 | chr2 | 203152447 | + | BMPR2 | chr2 | 203329532 | + |
| In-frame | ENST00000264279 | ENST00000374580 | NOP58 | chr2 | 203152447 | + | BMPR2 | chr2 | 203329532 | + |
| intron-3CDS | ENST00000467734 | ENST00000374574 | NOP58 | chr2 | 203152447 | + | BMPR2 | chr2 | 203329532 | + |
| intron-3CDS | ENST00000467734 | ENST00000374580 | NOP58 | chr2 | 203152447 | + | BMPR2 | chr2 | 203329532 | + |
| intron-intron | ENST00000467734 | ENST00000479069 | NOP58 | chr2 | 203152447 | + | BMPR2 | chr2 | 203329532 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000264279 | NOP58 | chr2 | 203152447 | + | ENST00000374580 | BMPR2 | chr2 | 203329532 | + | 11571 | 725 | 226 | 3765 | 1179 |
| ENST00000264279 | NOP58 | chr2 | 203152447 | + | ENST00000374574 | BMPR2 | chr2 | 203329532 | + | 10291 | 725 | 226 | 2241 | 671 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000264279 | ENST00000374580 | NOP58 | chr2 | 203152447 | + | BMPR2 | chr2 | 203329532 | + | 0.000134933 | 0.99986506 |
| ENST00000264279 | ENST00000374574 | NOP58 | chr2 | 203152447 | + | BMPR2 | chr2 | 203329532 | + | 0.000543249 | 0.9994567 |
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Fusion Genomic Features for NOP58-BMPR2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| NOP58 | chr2 | 203152447 | + | BMPR2 | chr2 | 203329531 | + | 1.87E-08 | 1 |
| NOP58 | chr2 | 203152447 | + | BMPR2 | chr2 | 203329531 | + | 1.87E-08 | 1 |
| NOP58 | chr2 | 203152447 | + | BMPR2 | chr2 | 203329531 | + | 1.87E-08 | 1 |
| NOP58 | chr2 | 203152447 | + | BMPR2 | chr2 | 203329531 | + | 1.87E-08 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for NOP58-BMPR2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:203242273/chr2:203139836) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NOP58 | BMPR2 |
| FUNCTION: Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. {ECO:0000250, ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:17636026, ECO:0000269|PubMed:19620283}. | FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. {ECO:0000250|UniProtKB:O35607}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | BMPR2 | chr2:203152447 | chr2:203329532 | ENST00000374580 | 0 | 13 | 547_550 | 25 | 1039.0 | Compositional bias | Note=Poly-Ser | |
| Tgene | BMPR2 | chr2:203152447 | chr2:203329532 | ENST00000374580 | 0 | 13 | 610_618 | 25 | 1039.0 | Compositional bias | Note=Poly-Thr | |
| Tgene | BMPR2 | chr2:203152447 | chr2:203329532 | ENST00000374580 | 0 | 13 | 901_908 | 25 | 1039.0 | Compositional bias | Note=Poly-Asn | |
| Tgene | BMPR2 | chr2:203152447 | chr2:203329532 | ENST00000374580 | 0 | 13 | 203_504 | 25 | 1039.0 | Domain | Protein kinase | |
| Tgene | BMPR2 | chr2:203152447 | chr2:203329532 | ENST00000374580 | 0 | 13 | 209_217 | 25 | 1039.0 | Nucleotide binding | ATP | |
| Tgene | BMPR2 | chr2:203152447 | chr2:203329532 | ENST00000374580 | 0 | 13 | 280_282 | 25 | 1039.0 | Nucleotide binding | ATP | |
| Tgene | BMPR2 | chr2:203152447 | chr2:203329532 | ENST00000374580 | 0 | 13 | 337_338 | 25 | 1039.0 | Nucleotide binding | ATP | |
| Tgene | BMPR2 | chr2:203152447 | chr2:203329532 | ENST00000374580 | 0 | 13 | 172_1038 | 25 | 1039.0 | Topological domain | Cytoplasmic | |
| Tgene | BMPR2 | chr2:203152447 | chr2:203329532 | ENST00000374580 | 0 | 13 | 27_150 | 25 | 1039.0 | Topological domain | Extracellular | |
| Tgene | BMPR2 | chr2:203152447 | chr2:203329532 | ENST00000374580 | 0 | 13 | 151_171 | 25 | 1039.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NOP58 | chr2:203152447 | chr2:203329532 | ENST00000264279 | + | 6 | 15 | 441_524 | 166 | 530.0 | Compositional bias | Note=Lys-rich |
| Hgene | NOP58 | chr2:203152447 | chr2:203329532 | ENST00000264279 | + | 6 | 15 | 282_400 | 166 | 530.0 | Domain | Nop |
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Fusion Gene Sequence for NOP58-BMPR2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >59651_59651_1_NOP58-BMPR2_NOP58_chr2_203152447_ENST00000264279_BMPR2_chr2_203329532_ENST00000374574_length(transcript)=10291nt_BP=725nt GTTGCTATCCCAGAATCCTCAGAGAAGGAGTAGCGCGTTCGTGCGTCCTAGTTCCAGTACAGCGTGGAGGGTTTAGGCAGCGTGTTCTGA TTCTTTGCGGGACGGCGAGCGCATTTGTGCTTTGCCCGCCGCGGCCTAGGAGGCCTTTTGAGGCCGCGTAGTCGGTGTTTTTGAACTGAC TCTACAGCTTCTGGCAGGCCGTGCGGCGCCCTGACCCGGCCTCACCATGTTGGTGCTGTTTGAAACGTCTGTGGGTTACGCCATCTTTAA GGTTCTAAATGAGAAGAAACTTCAAGAGGTTGATAGTTTATGGAAAGAATTTGAAACTCCAGAGAAAGCAAACAAAATAGTAAAGCTAAA ACATTTTGAGAAATTTCAGGATACAGCAGAAGCATTAGCAGCATTCACAGCTCTGATGGAGGGCAAAATCAATAAGCAGCTGAAAAAAGT TCTGAAGAAAATAGTAAAAGAAGCCCATGAACCGCTGGCAGTAGCTGATGCTAAACTAGGAGGGGTCATAAAGGAAAAGCTGAATCTCAG TTGTATCCATAGTCCTGTTGTTAATGAACTTATGAGAGGAATTCGTTCACAAATGGATGGATTAATCCCTGGGGTAGAACCACGTGAAAT GGCAGCTATGTGTCTTGGATTGGCTCACAGCCTGTCTCGATATAGATTGAAGTTTAGCGCTGATAAAGTAGACACAATGATTGTTCAGGC AATTTCTTCGCAGAATCAAGAACGGCTATGTGCGTTTAAAGATCCGTATCAGCAAGACCTTGGGATAGGTGAGAGTAGAATCTCTCATGA AAATGGGACAATATTATGCTCGAAAGGTAGCACCTGCTATGGCCTTTGGGAGAAATCAAAAGGGGACATAAATCTTGTAAAACAAGGATG TTGGTCTCACATTGGAGATCCCCAAGAGTGTCACTATGAAGAATGTGTAGTAACTACCACTCCTCCCTCAATTCAGAATGGAACATACCG TTTCTGCTGTTGTAGCACAGATTTATGTAATGTCAACTTTACTGAGAATTTTCCACCTCCTGACACAACACCACTCAGTCCACCTCATTC ATTTAACCGAGATGAGACAATAATCATTGCTTTGGCATCAGTCTCTGTATTAGCTGTTTTGATAGTTGCCTTATGCTTTGGATACAGAAT GTTGACAGGAGACCGTAAACAAGGTCTTCACAGTATGAACATGATGGAGGCAGCAGCATCCGAACCCTCTCTTGATCTAGATAATCTGAA ACTGTTGGAGCTGATTGGCCGAGGTCGATATGGAGCAGTATATAAAGGCTCCTTGGATGAGCGTCCAGTTGCTGTAAAAGTGTTTTCCTT TGCAAACCGTCAGAATTTTATCAACGAAAAGAACATTTACAGAGTGCCTTTGATGGAACATGACAACATTGCCCGCTTTATAGTTGGAGA TGAGAGAGTCACTGCAGATGGACGCATGGAATATTTGCTTGTGATGGAGTACTATCCCAATGGATCTTTATGCAAGTATTTAAGTCTCCA CACAAGTGACTGGGTAAGCTCTTGCCGTCTTGCTCATTCTGTTACTAGAGGACTGGCTTATCTTCACACAGAATTACCACGAGGAGATCA TTATAAACCTGCAATTTCCCATCGAGATTTAAACAGCAGAAATGTCCTAGTGAAAAATGATGGAACCTGTGTTATTAGTGACTTTGGACT GTCCATGAGGCTGACTGGAAATAGACTGGTGCGCCCAGGGGAGGAAGATAATGCAGCCATAAGCGAGGTTGGCACTATCAGATATATGGC ACCAGAAGTGCTAGAAGGAGCTGTGAACTTGAGGGACTGTGAATCAGCTTTGAAACAAGTAGACATGTATGCTCTTGGACTAATCTATTG GGAGATATTTATGAGATGTACAGACCTCTTCCCAGGGGAATCCGTACCAGAGTACCAGATGGCTTTTCAGACAGAGGTTGGAAACCATCC CACTTTTGAGGATATGCAGGTTCTCGTGTCTAGGGAAAAACAGAGACCCAAGTTCCCAGAAGCCTGGAAAGAAAATAGCCTGGCAGTGAG GTCACTCAAGGAGACAATCGAAGACTGTTGGGACCAGGATGCAGAGGCTCGGCTTACTGCACAGTGTGCTGAGGAAAGGATGGCTGAACT TATGATGATTTGGGAAAGAAACAAATCTGTGAGCCCAACAGTCAATCCAATGTCTACTGCTATGCAGAATGAACGTAGGTGAGTCAACAC AAGATGGCAAATCAGGATCAGGTGAAAAGATCAAGAAACGTGTGAAAACTCCCTATTCTCTTAAGCGGTGGCGCCCCTCCACCTGGGTCA TCTCCACTGAATCGCTGGACTGTGAAGTCAACAATAATGGCAGTAACAGGGCAGTTCATTCCAAATCCAGCACTGCTGTTTACCTTGCAG AAGGAGGCACTGCTACAACCATGGTGTCTAAAGATATAGGAATGAACTGTCTGTGAAATGTTTTCAAGCCTATGGAGTGAAATTATTTTT TGCATCATTTAAACATGCAGAAGATGTTTAAAAATAAAAAAAAAACTGCTTTATCCTCCTGTCAGCACCCCCTCCCACCCCTGCAACAAA GACTTGCTTTAAATAGATTTCAGCTATGCAGAAAAATTTAGCTTATGCTTCCATATTTTTAAATTTTGTTTTTTAAGTTTTGCACTTTTG TTTAGTCTCGCTAAAGTTATATTTGTCTGTTATGACCACAGAGTTATATGTGTGTGTATCAAAAGTGGTCTCAAAATATTTTTTTAAGAA AAAAAGCAAAAACAATGTATTGCTGATAATCAGTTTGGACCAGTTTCTTAAGGTCATTAAAACAGAAGCAAATTAAGACAGGTTTGACTG CAGTGGTGTCTGGTATCCATGTTTTATTTCTGGGCACAAGCTAGTTTTTATGTTGATACGTTCCTGAACATATTATCTTGTTGGACATCT TTTCTCTTGTGTTTTGTTTGAATGTGCAATAGTTTATAGGCCACAAATAAGCTTTCTTGTAAGCTCTCTTCCTAACAGGGCACATATTCT TCCATAATATAAACACTTTTCTGCCCCATCTCCCATACTTTTGAAGGTCAGTTCTATGACAGTGAATTTTGCACAGGAGAAGCAGCTACC TGATTTCTTACTTTCTCTCTCCTTATCATGGAGAATACAGAAACATTGTCTGAAAGGGCTCTAAAGAAGGAACTACCAAAACCTGACTTG AAATGCCATTTCTTTTAACCTTCCAAATCCTAAATGTTTCCTTCAAGGCATCTTAATAAACTTATTTGCTTCTGGTTTTGGGAGTTCATA AGAGAGAATAGAACAAAATACAGGACATCAAATATTAGCCATTTCCCATTTTATTTTATTTTTCTATGTAGGTTCATGTTCCATGTTCAT TTATTTAAGAAATACATTTTTATTGGTAAGCTTATAGAGCTACACTTATGGAATTTTTAAGTAGGTAAATAAATGGTTAAGACAAAATAG TGTTATAGCCTTCATTCTCTGAATAGGCCATCTTTGACTCATAAAATTACCCTTACTGTTTATTATAACTTCAGAAGTAATTTATAGTTC TGAACCTATAGTATCTTTTACCCTGTTCCCAAGCAAAGACTGGTGACTTTATCTGAAAATGATTCCTCTTCCCATGACCTAAAACACTGT GAGGAAAAATCATTCAAGTGGCATGCCAAGTCCCTATGAAGGAAGGGCTGCTATCAAACCTACCTTTTTTGAGCAAACTGAGACTAAACT TCTCTCTTTTCAAAATTGTGTTATCTTCCTTAATCCTATTTTCATAATTTTTCCTTTTGCCAGTTTTTCACATTATCTTTGATATGTGAG CAACATTTATTATTTACATTAGAGTATACCTTTTAGTAATAAAATGACTTGAAATCATATTATTTTTAAAAGCCCTTTGCTTCTTTCATT ACTTATAATCTCCTCTAAAACAACCTCTGCATGTTTTTTTTAAATAAAGCACTTTCTGTCAAATAATGGACTTTTTTCTAAACAGAAATT ATTTTCTATTAATTTGCAAACTGATGATTTCACTTTTTTTTACTTTTTTTTCGATTATCAGAGTACTTAGTAAATGTTATATAGTTTAGT TCTAAGATAGTTCCAGGGATTAAAAGGTTAAGAGGAAAACACAAATCACCAAATTTCTGATTTATGTTTTTATCTCCTGAACAATATTTT CTCACTCATATTCCTCTATCTTATCACTTAGCTAAAGACAGCCTAAATTTCCCAATTTTCTGTCCAAAATATTTGTGATTTACTTGTATA TAAGCCTTCTCATTTGCCATGTGCTGTGATCTTACAAGTTAGATGTTACTATACCTACCATTTATTCAGCTGGATTGCTGAACACAGTTC TGGATTCATAGAATTAAGAATATCTTGTTAGTGCCCAGGATTTCCACGTTTTGTGTTTTATTGGCCCTTTTCTTTATTCAGCCCCTTAAT CTATTTTCAGTCTTCTGGCACGTAATTTTTTTCACAGTTATTATTCTTCTATTAACAAATTATTTTTATCTTTCCTAGTACATTTTCACT TAGTTCTCTTGCCCTTAAATATCTTTCACATGCATTTTAGGATATTCTTTTCAAATATTTGTAGGACAACTTTGAATCAAAATAAATTAT GTTCCTTCTCCAATTTGAAGCATTGAGGATAAATGACCATTTGAGGTCTAACTGATCTTTTCCTGCCAGAAGAGTTATCTTACGTTCTGC TATATTTGTATTTGGGCCAGTTGATTGTAGGTTGTCCAACATTTTTTAATATTGGGAAAATTATGATAAAATGCTTTAAAAATTAATATG CCAGATTAAAATAACTGAATAGTTTACTATTTCATTCAAGCATGTTTAAAACAAATAATTTCCTTTCACCAGTTTTTCTTAGTAAACTCC TGAAAAAGTAGGAAAGGTGGAAAGTATATATCATTTTTATAAATTTTAAATTGTACATCAGACTTTTAAAATCTGTAATATACAAGCAAG CAAAATTATTTTAAATGACTTAATTGTATGCTAATACTCATCTGATAATAAATGCTTCTTAAAGTTGACATTTAACTGCTATCACAAAGT TTTATATGTAGAAAAGTGGGGTCCTTTTGAATAAAAGATCATTCAACTAAAAATATTAAAATTTATTTCACTGGATGGTAATGTAACCTT AAAAGCATCATAATAGGTAAAGTCTAATATTAGTTCCCTTAACAAAATCCTAACTGTATACCAGAATTAGGTCACTGAAAGAACTTGATT TGAATTACGTTTAGACAAAAATGATTTAATTGTAAATTCTTAAAACTTTCTAAATGCATAATTGGCAAAAAAAAAAACCCACTGTTACCA GTGTAGGAAGTTACAAGAAGGCACATACTGAATGCTGAAGTATACATATGCTATTTCTCTTAAACCTCAGAGCAACCATATGAGCATTGT AATTAATATTCCCATTTTACAGATGAGGAAACTGAAGCTAAGAGAAGCTAAGTAATATGCCCAAGGTCCACATCTAGTAACAGACAAAGC TGGGATTTCAGTCTATGTCTGCCTCTCTCCACATCTCTTTCATCCATACCACACTGCCTACATGCCATATGACAGGATGTGTAATGGGCT AACGTTTATTTAAAAAGTTCAGGCCAGGTGCAGTGGCTTATGCCTATAATCCCCGCACTTTGGGAGGCCGAGCCGGGTGGATCATGAGGT CAGACGTTCAACACCAGCCTGGCCAAGATGGTGAAACCCCGTCTCTATTAAAAATATTTTTTAAAAATTAACTGAGCGTGGTGGTGGGCG CCTGTAGTCCCAGCTACTCAGGAGGCTAAGGCAGGAGAATCTCTTGAACCCGAGAGGTGGAGGTTGCAGTGAGCTGAGATCGCGCCACTG CACTGCAGCCTAGGCGACAGAGCAAGACTGCCTCAAAAAAAAAACATAAAAATTCAGTCACTATACTCTGGCACAATTTTCATTTGTATA TGAGCCAAACCACATACCTTAATGATTTGGGAAGTTAGGCAAATATGAGATATGTAGACATATCTATGCTGATTGTTGCTTGAGAAATAA TTACTAATTCTAGACAAAACTCAATCCTGTATCTTCCATCATGAATCTTAAAATCATTTCACTTCACTCCTAACATTTCTTACATTGCAG AACTAATGGTAAAGTAAATTTTACGGAAAAAGTTAAGATAGCTTTGGGAACAGAGACCTTTCCCTAAATTGATTCCATAGCAGATTTGGG GGAATTAACAAAGAATTTCAGTCTCATCAATCCTTTGAATCCATCTTCAAAACTTCTGCTTTTAATAACTTTAGAAAATTTACTAATCTA TAGAACTAATTGAGTAGGATATAGGAAGGATACAAGGATATAATGTCCTTTTTATAAAAGTTTAGTATAGCTTCTTTACATGTATCCACT TGTTCCAGAAAATGTGCATTGGTTCTGAATGTGAAAATATTTAAAGAGAGAAAGGAACACTCAAGTAAGTGTGGGCTTCAGTGGGAATTA TCACAAAACATTGGCAAGTATTTTTATTTAAATTATTTTCAAATTTGACTTCTACAGCCAAGTGGAATTGGTAGGCTGTAGCTGTTACAC TGAAATTTCTAGTCTTTGTAAGTGCCTCCTGAAAGTCATTTAAAATGGAAAAATATTTCAATGAGCTTTTCCTTTTTTCATATTTATGGA CATGAATATTTTATTGGAGATCATTAACTCCTAGAATTTGAGATTATATTTCCATACAACATTTTATAAAGTTATGTTGAACTTACTACC TGTTATGTGCAGGTTATTATGTAACTATTCACAGATTGCTTCATATATTGCTTTATCTTCCCATCTAACTTCTTAAAGTTAAAATCCGGA CACACATGTTGATTATCTAGACCAGTCATTCTGGAAATTGTAACACTCCCACATAAACCCCAGGAGACTTTTTCAGAATGCAATGTTTCT AAATGTACTGTTACTGGCAGTTTACTCTCCAGCATATAAGGTTGCATTTTAACTTTTAGATTATGAACTGTGCAAACTTTACCCAAAACT ATCTTGCATGATTCCCTCCTAAATATATTCCTTGATTAAGTAAATCTGGCAAATCACTGTTTGAGCTAGTTACATAAAATTTGTTATCAA GAGAAGGCTTTTCTACAAGTTTCCAGATTAACATAAAGAAAAGAGGGAATCACAGGGCATTTAAGTGCACCTTCCCATTACTTTCCTTAA ATCACCTCATAGTTAGGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGACGGTGGATCACGAGGTCAGGGGA CTGAGATCATCCTGGCTAACACGATGAAACCTCATCTCTACTAAAAATACAAATAATTAGCCAGGCATGGTGGCACGCGCCTGTAGTCCC AGCTACTCGGGAGGCAGAGACAGGAGAATCGTTTGCACCCGGGAGGCGGAGGTTGTTGCAGTGAGCCGAGATCGCGCCAATGCACTCCAG CCTGGGCTACAGAGTGAGACTCCATCTCAAAAAAAAACAAAAAAAATCACCTCATAGTTTATGTCTGACTTACTCCAAACCTCAGTTATC TGATTTGTAGTCTGTGTCAGGAAAGTTTTCTTCATATCTATTCTGTCTCCCTCCTCTTTGATTTTAAATTTTTTTCTTTTACCCAGTAGG ACAAAAAAGAGCAGTTGGTCATCATCCCCAATATTCTTAGTCTTCAGTATGCTTCAGGCCTCTCAATGAACACTTAAGTCTCAATTCTTC AGACAAAATTGCTTAAGCTCTTCTCCTCAGTCCTATTTTAATGACTTTATATTTAAGAATATAGAATTATATTTTCTTTTATATTCAAAT TCATTACTCCAGTTAAGTAATAGTTTGATAGTTTGATAGAATCGAGAGTTAAGATGTTTCTATTTGAAAGTGGATTCAACCATCAGACCA CCAGCAAATCGGCACTTAATTTTTGTGTTATCTAACATTTTCTATTGTGGAATTTTATGATTTTATATTCTCATTAGTTATAACTAAAAA GCCATGCACACAGAATTGTATATCATTTTGCCATTAAAATTTTTTAACATATTGCAGCAAGCTTAGTTTTATGATTGAGCCACAACCTTT TACATATTTTTTGTATGAAATATTAAACACTAAATGCAAGATTAACTTTCAAAAGCAAACCCTACATTAATCAGGTATTATCTATGGACA TTTTTGTAGACCACTTTTGAAATACTTATTATTTTGCAACATAGACTGGACTATACAACTTTCATTTAACTTTTAGGTGACTGATTTAAG TTGAGTGTGCATATAGAGAAAAACCTAGAAATTTATCTCATGGCAGATACATTTGAAAGTACTTCAGAAGAATTTATGCTGTATATTAAA ACTAGGCTCAAAATAAATCTATCGTATCTTTAAAAGTCCAATTCTGTTATTACTGTGATGTTTGTAGTGTTACTATTAAACATTGTGAAC ATACACATTTTTAAAACAACTTGAAACCCATTTTAAAATCTGGGTAAGAGAGAAGGAATCTTCAGAACAAAATCACATCATTAGGGTGTC CAGTTTATGATTGAATTTTTAAGCAAATTACTGTATTTGAAACTACAACTTGATTTGGTTTTCAGTTTTAAAAGGCAACATGTGGGTTTT ATCCATTTTATTTATACCTTTAGATTTCAGAAACATCTTCATGTTTTAGATGCATTCTACAGACATCATGTTACTTAAAAACTCAGGGCC CCTTTCATCCCTTTGTACACTGAAAAAGTTCAATTGTTAGCAAGTAAGCAATTAGATCCAGTTGAATATTTAAAGTGTTTGTTGCACAGT TCATTTAATGTTTCATCTTATTTGACTTTTTCACATAGATATAATATCAGATTTCATTAATTATAAAAAGTTGCCCAGTTCTGTAATTAC TGAACAGAGGGAATGACTCAACTAATTGGCTACATGTTGCAACAAATTTAGGCCTTTAGAGTTGAAGCACTGACTTAAAACGACTTACAT TTCTGTTCTTTGGTCAAATGACCATACATGATATGGGACAAATTGTTTCATTTTGTTTGTTTTTTAATAAGGGAACTTGGTAAAGTAGTT CCTGTCAGATAGGATTTTCTCAAGAGACAATTTAACGTTATAAAGCCTTCTAAAAGTGAACTAAATATTTTATAACTTTAGTAATAGCTT GGATGGTTTTGAGAAAATAACCTGTATTTATCACATTGTCAAACAGAATTTTTCTTTGAATCAGACAAGTTCAAGCTCTAAATTGATGTG CTATATACTTAAAATCCTAGGAAGTTATCTGTAACCAGTCTCTTGTCTCAGGCTCTTCACCTTGTTACCAATCCTCGTAAGTATGTAAAG GAAACATATTTTTAAAGAAGCTTAACAGTAAGAAAAAATTACTAAAAGATGCAATTCAAAGATAGGTCCCAGTTTAACACTGAATTGCTT GACTTCTGTGGCTTTTCTTTTTCTGGCCACATTTATTTATTTAAGCAATTTTTGTATGCCTTGTTATTTCATTTCCATAGAGATTATATT GTATCAGTGTTTATGTAAGCTGGAATCATCCTCAGTTTTTTGCTGATAATTTTTCAAATAAAGATACATGGATAATTGTAAAATACACTA ACTCTTAGGGTGTTGTAGTAGCTGAAACATGGAGATGCGTAGCTGTCATGCTTTTTCTGAATGGACAGGAGAAACATAAGCTACGGAGTA TTCACTTCTGAGGATGCTTTTCCGGAAAAAGAAAGGCTAGAAAATACTCGCACTTCCTCAGAACCCTCTTTCTTGTTAACGGGTATCTTT TGTTGGTGTGTTTTGCTCTTACATTACAGATAGACTATCATATATGACTTTATGAATAATTTCAGTTATTTTGCTTTTGTATAAGCTGTC TGAAGCCTTGCTATGCTGTATAAGTTGTGTTTGATGGATCAGTGTGAGTATAAAATAAAGCAAATCACTTTTCTTTTGTATTATCTATGG ATGCCACTATGAAAGCTGACATTAAGCCACTAAAGAGTTTTCTATGAATAAGTGTAAGTAAATGCTTTGATATATATAAACCTAAATAAA AAGATTGTATTGATACAGAGACATTGGAGAAGGAGATTTTAAGGCAGTTCTTTAGGTTTAAAAAGGCTTGCTGTAAAATGGTGCGTTATT >59651_59651_1_NOP58-BMPR2_NOP58_chr2_203152447_ENST00000264279_BMPR2_chr2_203329532_ENST00000374574_length(amino acids)=671AA_BP=0 MLVLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPEKANKIVKLKHFEKFQDTAEALAAFTALMEGKINKQLKKVLKKIVKEAHEPLAVA DAKLGGVIKEKLNLSCIHSPVVNELMRGIRSQMDGLIPGVEPREMAAMCLGLAHSLSRYRLKFSADKVDTMIVQAISSQNQERLCAFKDP YQQDLGIGESRISHENGTILCSKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCSTDLCNVNFTE NFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRKQGLHSMNMMEAAASEPSLDLDNLKLLELIGRGRYGAVYK GSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVT RGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCES ALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAE -------------------------------------------------------------- >59651_59651_2_NOP58-BMPR2_NOP58_chr2_203152447_ENST00000264279_BMPR2_chr2_203329532_ENST00000374580_length(transcript)=11571nt_BP=725nt GTTGCTATCCCAGAATCCTCAGAGAAGGAGTAGCGCGTTCGTGCGTCCTAGTTCCAGTACAGCGTGGAGGGTTTAGGCAGCGTGTTCTGA TTCTTTGCGGGACGGCGAGCGCATTTGTGCTTTGCCCGCCGCGGCCTAGGAGGCCTTTTGAGGCCGCGTAGTCGGTGTTTTTGAACTGAC TCTACAGCTTCTGGCAGGCCGTGCGGCGCCCTGACCCGGCCTCACCATGTTGGTGCTGTTTGAAACGTCTGTGGGTTACGCCATCTTTAA GGTTCTAAATGAGAAGAAACTTCAAGAGGTTGATAGTTTATGGAAAGAATTTGAAACTCCAGAGAAAGCAAACAAAATAGTAAAGCTAAA ACATTTTGAGAAATTTCAGGATACAGCAGAAGCATTAGCAGCATTCACAGCTCTGATGGAGGGCAAAATCAATAAGCAGCTGAAAAAAGT TCTGAAGAAAATAGTAAAAGAAGCCCATGAACCGCTGGCAGTAGCTGATGCTAAACTAGGAGGGGTCATAAAGGAAAAGCTGAATCTCAG TTGTATCCATAGTCCTGTTGTTAATGAACTTATGAGAGGAATTCGTTCACAAATGGATGGATTAATCCCTGGGGTAGAACCACGTGAAAT GGCAGCTATGTGTCTTGGATTGGCTCACAGCCTGTCTCGATATAGATTGAAGTTTAGCGCTGATAAAGTAGACACAATGATTGTTCAGGC AATTTCTTCGCAGAATCAAGAACGGCTATGTGCGTTTAAAGATCCGTATCAGCAAGACCTTGGGATAGGTGAGAGTAGAATCTCTCATGA AAATGGGACAATATTATGCTCGAAAGGTAGCACCTGCTATGGCCTTTGGGAGAAATCAAAAGGGGACATAAATCTTGTAAAACAAGGATG TTGGTCTCACATTGGAGATCCCCAAGAGTGTCACTATGAAGAATGTGTAGTAACTACCACTCCTCCCTCAATTCAGAATGGAACATACCG TTTCTGCTGTTGTAGCACAGATTTATGTAATGTCAACTTTACTGAGAATTTTCCACCTCCTGACACAACACCACTCAGTCCACCTCATTC ATTTAACCGAGATGAGACAATAATCATTGCTTTGGCATCAGTCTCTGTATTAGCTGTTTTGATAGTTGCCTTATGCTTTGGATACAGAAT GTTGACAGGAGACCGTAAACAAGGTCTTCACAGTATGAACATGATGGAGGCAGCAGCATCCGAACCCTCTCTTGATCTAGATAATCTGAA ACTGTTGGAGCTGATTGGCCGAGGTCGATATGGAGCAGTATATAAAGGCTCCTTGGATGAGCGTCCAGTTGCTGTAAAAGTGTTTTCCTT TGCAAACCGTCAGAATTTTATCAACGAAAAGAACATTTACAGAGTGCCTTTGATGGAACATGACAACATTGCCCGCTTTATAGTTGGAGA TGAGAGAGTCACTGCAGATGGACGCATGGAATATTTGCTTGTGATGGAGTACTATCCCAATGGATCTTTATGCAAGTATTTAAGTCTCCA CACAAGTGACTGGGTAAGCTCTTGCCGTCTTGCTCATTCTGTTACTAGAGGACTGGCTTATCTTCACACAGAATTACCACGAGGAGATCA TTATAAACCTGCAATTTCCCATCGAGATTTAAACAGCAGAAATGTCCTAGTGAAAAATGATGGAACCTGTGTTATTAGTGACTTTGGACT GTCCATGAGGCTGACTGGAAATAGACTGGTGCGCCCAGGGGAGGAAGATAATGCAGCCATAAGCGAGGTTGGCACTATCAGATATATGGC ACCAGAAGTGCTAGAAGGAGCTGTGAACTTGAGGGACTGTGAATCAGCTTTGAAACAAGTAGACATGTATGCTCTTGGACTAATCTATTG GGAGATATTTATGAGATGTACAGACCTCTTCCCAGGGGAATCCGTACCAGAGTACCAGATGGCTTTTCAGACAGAGGTTGGAAACCATCC CACTTTTGAGGATATGCAGGTTCTCGTGTCTAGGGAAAAACAGAGACCCAAGTTCCCAGAAGCCTGGAAAGAAAATAGCCTGGCAGTGAG GTCACTCAAGGAGACAATCGAAGACTGTTGGGACCAGGATGCAGAGGCTCGGCTTACTGCACAGTGTGCTGAGGAAAGGATGGCTGAACT TATGATGATTTGGGAAAGAAACAAATCTGTGAGCCCAACAGTCAATCCAATGTCTACTGCTATGCAGAATGAACGCAACCTGTCACATAA TAGGCGTGTGCCAAAAATTGGTCCTTATCCAGATTATTCTTCCTCCTCATACATTGAAGACTCTATCCATCATACTGACAGCATCGTGAA GAATATTTCCTCTGAGCATTCTATGTCCAGCACACCTTTGACTATAGGGGAAAAAAACCGAAATTCAATTAACTATGAACGACAGCAAGC ACAAGCTCGAATCCCCAGCCCTGAAACAAGTGTCACCAGCCTCTCCACCAACACAACAACCACAAACACCACAGGACTCACGCCAAGTAC TGGCATGACTACTATATCTGAGATGCCATACCCAGATGAAACAAATCTGCATACCACAAATGTTGCACAGTCAATTGGGCCAACCCCTGT CTGCTTACAGCTGACAGAAGAAGACTTGGAAACCAACAAGCTAGACCCAAAAGAAGTTGATAAGAACCTCAAGGAAAGCTCTGATGAGAA TCTCATGGAGCACTCTCTTAAACAGTTCAGTGGCCCAGACCCACTGAGCAGTACTAGTTCTAGCTTGCTTTACCCACTCATAAAACTTGC AGTAGAAGCAACTGGACAGCAGGACTTCACACAGACTGCAAATGGCCAAGCATGTTTGATTCCTGATGTTCTGCCTACTCAGATCTATCC TCTCCCCAAGCAGCAGAACCTTCCCAAGAGACCTACTAGTTTGCCTTTGAACACCAAAAATTCAACAAAAGAGCCCCGGCTAAAATTTGG CAGCAAGCACAAATCAAACTTGAAACAAGTCGAAACTGGAGTTGCCAAGATGAATACAATCAATGCAGCAGAACCTCATGTGGTGACAGT CACCATGAATGGTGTGGCAGGTAGAAACCACAGTGTTAACTCCCATGCTGCCACAACCCAATATGCCAATGGGACAGTACTATCTGGCCA AACAACCAACATAGTGACACATAGGGCCCAAGAAATGTTGCAGAATCAGTTTATTGGTGAGGACACCCGGCTGAATATTAATTCCAGTCC TGATGAGCATGAGCCTTTACTGAGACGAGAGCAACAAGCTGGCCATGATGAAGGTGTTCTGGATCGTCTTGTGGACAGGAGGGAACGGCC ACTAGAAGGTGGCCGAACTAATTCCAATAACAACAACAGCAATCCATGTTCAGAACAAGATGTTCTTGCACAGGGTGTTCCAAGCACAGC AGCAGATCCTGGGCCATCAAAGCCCAGAAGAGCACAGAGGCCTAATTCTCTGGATCTTTCAGCCACAAATGTCCTGGATGGCAGCAGTAT ACAGATAGGTGAGTCAACACAAGATGGCAAATCAGGATCAGGTGAAAAGATCAAGAAACGTGTGAAAACTCCCTATTCTCTTAAGCGGTG GCGCCCCTCCACCTGGGTCATCTCCACTGAATCGCTGGACTGTGAAGTCAACAATAATGGCAGTAACAGGGCAGTTCATTCCAAATCCAG CACTGCTGTTTACCTTGCAGAAGGAGGCACTGCTACAACCATGGTGTCTAAAGATATAGGAATGAACTGTCTGTGAAATGTTTTCAAGCC TATGGAGTGAAATTATTTTTTGCATCATTTAAACATGCAGAAGATGTTTAAAAATAAAAAAAAAACTGCTTTATCCTCCTGTCAGCACCC CCTCCCACCCCTGCAACAAAGACTTGCTTTAAATAGATTTCAGCTATGCAGAAAAATTTAGCTTATGCTTCCATATTTTTAAATTTTGTT TTTTAAGTTTTGCACTTTTGTTTAGTCTCGCTAAAGTTATATTTGTCTGTTATGACCACAGAGTTATATGTGTGTGTATCAAAAGTGGTC TCAAAATATTTTTTTAAGAAAAAAAGCAAAAACAATGTATTGCTGATAATCAGTTTGGACCAGTTTCTTAAGGTCATTAAAACAGAAGCA AATTAAGACAGGTTTGACTGCAGTGGTGTCTGGTATCCATGTTTTATTTCTGGGCACAAGCTAGTTTTTATGTTGATACGTTCCTGAACA TATTATCTTGTTGGACATCTTTTCTCTTGTGTTTTGTTTGAATGTGCAATAGTTTATAGGCCACAAATAAGCTTTCTTGTAAGCTCTCTT CCTAACAGGGCACATATTCTTCCATAATATAAACACTTTTCTGCCCCATCTCCCATACTTTTGAAGGTCAGTTCTATGACAGTGAATTTT GCACAGGAGAAGCAGCTACCTGATTTCTTACTTTCTCTCTCCTTATCATGGAGAATACAGAAACATTGTCTGAAAGGGCTCTAAAGAAGG AACTACCAAAACCTGACTTGAAATGCCATTTCTTTTAACCTTCCAAATCCTAAATGTTTCCTTCAAGGCATCTTAATAAACTTATTTGCT TCTGGTTTTGGGAGTTCATAAGAGAGAATAGAACAAAATACAGGACATCAAATATTAGCCATTTCCCATTTTATTTTATTTTTCTATGTA GGTTCATGTTCCATGTTCATTTATTTAAGAAATACATTTTTATTGGTAAGCTTATAGAGCTACACTTATGGAATTTTTAAGTAGGTAAAT AAATGGTTAAGACAAAATAGTGTTATAGCCTTCATTCTCTGAATAGGCCATCTTTGACTCATAAAATTACCCTTACTGTTTATTATAACT TCAGAAGTAATTTATAGTTCTGAACCTATAGTATCTTTTACCCTGTTCCCAAGCAAAGACTGGTGACTTTATCTGAAAATGATTCCTCTT CCCATGACCTAAAACACTGTGAGGAAAAATCATTCAAGTGGCATGCCAAGTCCCTATGAAGGAAGGGCTGCTATCAAACCTACCTTTTTT GAGCAAACTGAGACTAAACTTCTCTCTTTTCAAAATTGTGTTATCTTCCTTAATCCTATTTTCATAATTTTTCCTTTTGCCAGTTTTTCA CATTATCTTTGATATGTGAGCAACATTTATTATTTACATTAGAGTATACCTTTTAGTAATAAAATGACTTGAAATCATATTATTTTTAAA AGCCCTTTGCTTCTTTCATTACTTATAATCTCCTCTAAAACAACCTCTGCATGTTTTTTTTAAATAAAGCACTTTCTGTCAAATAATGGA CTTTTTTCTAAACAGAAATTATTTTCTATTAATTTGCAAACTGATGATTTCACTTTTTTTTACTTTTTTTTCGATTATCAGAGTACTTAG TAAATGTTATATAGTTTAGTTCTAAGATAGTTCCAGGGATTAAAAGGTTAAGAGGAAAACACAAATCACCAAATTTCTGATTTATGTTTT TATCTCCTGAACAATATTTTCTCACTCATATTCCTCTATCTTATCACTTAGCTAAAGACAGCCTAAATTTCCCAATTTTCTGTCCAAAAT ATTTGTGATTTACTTGTATATAAGCCTTCTCATTTGCCATGTGCTGTGATCTTACAAGTTAGATGTTACTATACCTACCATTTATTCAGC TGGATTGCTGAACACAGTTCTGGATTCATAGAATTAAGAATATCTTGTTAGTGCCCAGGATTTCCACGTTTTGTGTTTTATTGGCCCTTT TCTTTATTCAGCCCCTTAATCTATTTTCAGTCTTCTGGCACGTAATTTTTTTCACAGTTATTATTCTTCTATTAACAAATTATTTTTATC TTTCCTAGTACATTTTCACTTAGTTCTCTTGCCCTTAAATATCTTTCACATGCATTTTAGGATATTCTTTTCAAATATTTGTAGGACAAC TTTGAATCAAAATAAATTATGTTCCTTCTCCAATTTGAAGCATTGAGGATAAATGACCATTTGAGGTCTAACTGATCTTTTCCTGCCAGA AGAGTTATCTTACGTTCTGCTATATTTGTATTTGGGCCAGTTGATTGTAGGTTGTCCAACATTTTTTAATATTGGGAAAATTATGATAAA ATGCTTTAAAAATTAATATGCCAGATTAAAATAACTGAATAGTTTACTATTTCATTCAAGCATGTTTAAAACAAATAATTTCCTTTCACC AGTTTTTCTTAGTAAACTCCTGAAAAAGTAGGAAAGGTGGAAAGTATATATCATTTTTATAAATTTTAAATTGTACATCAGACTTTTAAA ATCTGTAATATACAAGCAAGCAAAATTATTTTAAATGACTTAATTGTATGCTAATACTCATCTGATAATAAATGCTTCTTAAAGTTGACA TTTAACTGCTATCACAAAGTTTTATATGTAGAAAAGTGGGGTCCTTTTGAATAAAAGATCATTCAACTAAAAATATTAAAATTTATTTCA CTGGATGGTAATGTAACCTTAAAAGCATCATAATAGGTAAAGTCTAATATTAGTTCCCTTAACAAAATCCTAACTGTATACCAGAATTAG GTCACTGAAAGAACTTGATTTGAATTACGTTTAGACAAAAATGATTTAATTGTAAATTCTTAAAACTTTCTAAATGCATAATTGGCAAAA AAAAAAACCCACTGTTACCAGTGTAGGAAGTTACAAGAAGGCACATACTGAATGCTGAAGTATACATATGCTATTTCTCTTAAACCTCAG AGCAACCATATGAGCATTGTAATTAATATTCCCATTTTACAGATGAGGAAACTGAAGCTAAGAGAAGCTAAGTAATATGCCCAAGGTCCA CATCTAGTAACAGACAAAGCTGGGATTTCAGTCTATGTCTGCCTCTCTCCACATCTCTTTCATCCATACCACACTGCCTACATGCCATAT GACAGGATGTGTAATGGGCTAACGTTTATTTAAAAAGTTCAGGCCAGGTGCAGTGGCTTATGCCTATAATCCCCGCACTTTGGGAGGCCG AGCCGGGTGGATCATGAGGTCAGACGTTCAACACCAGCCTGGCCAAGATGGTGAAACCCCGTCTCTATTAAAAATATTTTTTAAAAATTA ACTGAGCGTGGTGGTGGGCGCCTGTAGTCCCAGCTACTCAGGAGGCTAAGGCAGGAGAATCTCTTGAACCCGAGAGGTGGAGGTTGCAGT GAGCTGAGATCGCGCCACTGCACTGCAGCCTAGGCGACAGAGCAAGACTGCCTCAAAAAAAAAACATAAAAATTCAGTCACTATACTCTG GCACAATTTTCATTTGTATATGAGCCAAACCACATACCTTAATGATTTGGGAAGTTAGGCAAATATGAGATATGTAGACATATCTATGCT GATTGTTGCTTGAGAAATAATTACTAATTCTAGACAAAACTCAATCCTGTATCTTCCATCATGAATCTTAAAATCATTTCACTTCACTCC TAACATTTCTTACATTGCAGAACTAATGGTAAAGTAAATTTTACGGAAAAAGTTAAGATAGCTTTGGGAACAGAGACCTTTCCCTAAATT GATTCCATAGCAGATTTGGGGGAATTAACAAAGAATTTCAGTCTCATCAATCCTTTGAATCCATCTTCAAAACTTCTGCTTTTAATAACT TTAGAAAATTTACTAATCTATAGAACTAATTGAGTAGGATATAGGAAGGATACAAGGATATAATGTCCTTTTTATAAAAGTTTAGTATAG CTTCTTTACATGTATCCACTTGTTCCAGAAAATGTGCATTGGTTCTGAATGTGAAAATATTTAAAGAGAGAAAGGAACACTCAAGTAAGT GTGGGCTTCAGTGGGAATTATCACAAAACATTGGCAAGTATTTTTATTTAAATTATTTTCAAATTTGACTTCTACAGCCAAGTGGAATTG GTAGGCTGTAGCTGTTACACTGAAATTTCTAGTCTTTGTAAGTGCCTCCTGAAAGTCATTTAAAATGGAAAAATATTTCAATGAGCTTTT CCTTTTTTCATATTTATGGACATGAATATTTTATTGGAGATCATTAACTCCTAGAATTTGAGATTATATTTCCATACAACATTTTATAAA GTTATGTTGAACTTACTACCTGTTATGTGCAGGTTATTATGTAACTATTCACAGATTGCTTCATATATTGCTTTATCTTCCCATCTAACT TCTTAAAGTTAAAATCCGGACACACATGTTGATTATCTAGACCAGTCATTCTGGAAATTGTAACACTCCCACATAAACCCCAGGAGACTT TTTCAGAATGCAATGTTTCTAAATGTACTGTTACTGGCAGTTTACTCTCCAGCATATAAGGTTGCATTTTAACTTTTAGATTATGAACTG TGCAAACTTTACCCAAAACTATCTTGCATGATTCCCTCCTAAATATATTCCTTGATTAAGTAAATCTGGCAAATCACTGTTTGAGCTAGT TACATAAAATTTGTTATCAAGAGAAGGCTTTTCTACAAGTTTCCAGATTAACATAAAGAAAAGAGGGAATCACAGGGCATTTAAGTGCAC CTTCCCATTACTTTCCTTAAATCACCTCATAGTTAGGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGACGG TGGATCACGAGGTCAGGGGACTGAGATCATCCTGGCTAACACGATGAAACCTCATCTCTACTAAAAATACAAATAATTAGCCAGGCATGG TGGCACGCGCCTGTAGTCCCAGCTACTCGGGAGGCAGAGACAGGAGAATCGTTTGCACCCGGGAGGCGGAGGTTGTTGCAGTGAGCCGAG ATCGCGCCAATGCACTCCAGCCTGGGCTACAGAGTGAGACTCCATCTCAAAAAAAAACAAAAAAAATCACCTCATAGTTTATGTCTGACT TACTCCAAACCTCAGTTATCTGATTTGTAGTCTGTGTCAGGAAAGTTTTCTTCATATCTATTCTGTCTCCCTCCTCTTTGATTTTAAATT TTTTTCTTTTACCCAGTAGGACAAAAAAGAGCAGTTGGTCATCATCCCCAATATTCTTAGTCTTCAGTATGCTTCAGGCCTCTCAATGAA CACTTAAGTCTCAATTCTTCAGACAAAATTGCTTAAGCTCTTCTCCTCAGTCCTATTTTAATGACTTTATATTTAAGAATATAGAATTAT ATTTTCTTTTATATTCAAATTCATTACTCCAGTTAAGTAATAGTTTGATAGTTTGATAGAATCGAGAGTTAAGATGTTTCTATTTGAAAG TGGATTCAACCATCAGACCACCAGCAAATCGGCACTTAATTTTTGTGTTATCTAACATTTTCTATTGTGGAATTTTATGATTTTATATTC TCATTAGTTATAACTAAAAAGCCATGCACACAGAATTGTATATCATTTTGCCATTAAAATTTTTTAACATATTGCAGCAAGCTTAGTTTT ATGATTGAGCCACAACCTTTTACATATTTTTTGTATGAAATATTAAACACTAAATGCAAGATTAACTTTCAAAAGCAAACCCTACATTAA TCAGGTATTATCTATGGACATTTTTGTAGACCACTTTTGAAATACTTATTATTTTGCAACATAGACTGGACTATACAACTTTCATTTAAC TTTTAGGTGACTGATTTAAGTTGAGTGTGCATATAGAGAAAAACCTAGAAATTTATCTCATGGCAGATACATTTGAAAGTACTTCAGAAG AATTTATGCTGTATATTAAAACTAGGCTCAAAATAAATCTATCGTATCTTTAAAAGTCCAATTCTGTTATTACTGTGATGTTTGTAGTGT TACTATTAAACATTGTGAACATACACATTTTTAAAACAACTTGAAACCCATTTTAAAATCTGGGTAAGAGAGAAGGAATCTTCAGAACAA AATCACATCATTAGGGTGTCCAGTTTATGATTGAATTTTTAAGCAAATTACTGTATTTGAAACTACAACTTGATTTGGTTTTCAGTTTTA AAAGGCAACATGTGGGTTTTATCCATTTTATTTATACCTTTAGATTTCAGAAACATCTTCATGTTTTAGATGCATTCTACAGACATCATG TTACTTAAAAACTCAGGGCCCCTTTCATCCCTTTGTACACTGAAAAAGTTCAATTGTTAGCAAGTAAGCAATTAGATCCAGTTGAATATT TAAAGTGTTTGTTGCACAGTTCATTTAATGTTTCATCTTATTTGACTTTTTCACATAGATATAATATCAGATTTCATTAATTATAAAAAG TTGCCCAGTTCTGTAATTACTGAACAGAGGGAATGACTCAACTAATTGGCTACATGTTGCAACAAATTTAGGCCTTTAGAGTTGAAGCAC TGACTTAAAACGACTTACATTTCTGTTCTTTGGTCAAATGACCATACATGATATGGGACAAATTGTTTCATTTTGTTTGTTTTTTAATAA GGGAACTTGGTAAAGTAGTTCCTGTCAGATAGGATTTTCTCAAGAGACAATTTAACGTTATAAAGCCTTCTAAAAGTGAACTAAATATTT TATAACTTTAGTAATAGCTTGGATGGTTTTGAGAAAATAACCTGTATTTATCACATTGTCAAACAGAATTTTTCTTTGAATCAGACAAGT TCAAGCTCTAAATTGATGTGCTATATACTTAAAATCCTAGGAAGTTATCTGTAACCAGTCTCTTGTCTCAGGCTCTTCACCTTGTTACCA ATCCTCGTAAGTATGTAAAGGAAACATATTTTTAAAGAAGCTTAACAGTAAGAAAAAATTACTAAAAGATGCAATTCAAAGATAGGTCCC AGTTTAACACTGAATTGCTTGACTTCTGTGGCTTTTCTTTTTCTGGCCACATTTATTTATTTAAGCAATTTTTGTATGCCTTGTTATTTC ATTTCCATAGAGATTATATTGTATCAGTGTTTATGTAAGCTGGAATCATCCTCAGTTTTTTGCTGATAATTTTTCAAATAAAGATACATG GATAATTGTAAAATACACTAACTCTTAGGGTGTTGTAGTAGCTGAAACATGGAGATGCGTAGCTGTCATGCTTTTTCTGAATGGACAGGA GAAACATAAGCTACGGAGTATTCACTTCTGAGGATGCTTTTCCGGAAAAAGAAAGGCTAGAAAATACTCGCACTTCCTCAGAACCCTCTT TCTTGTTAACGGGTATCTTTTGTTGGTGTGTTTTGCTCTTACATTACAGATAGACTATCATATATGACTTTATGAATAATTTCAGTTATT TTGCTTTTGTATAAGCTGTCTGAAGCCTTGCTATGCTGTATAAGTTGTGTTTGATGGATCAGTGTGAGTATAAAATAAAGCAAATCACTT TTCTTTTGTATTATCTATGGATGCCACTATGAAAGCTGACATTAAGCCACTAAAGAGTTTTCTATGAATAAGTGTAAGTAAATGCTTTGA TATATATAAACCTAAATAAAAAGATTGTATTGATACAGAGACATTGGAGAAGGAGATTTTAAGGCAGTTCTTTAGGTTTAAAAAGGCTTG >59651_59651_2_NOP58-BMPR2_NOP58_chr2_203152447_ENST00000264279_BMPR2_chr2_203329532_ENST00000374580_length(amino acids)=1179AA_BP=0 MLVLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPEKANKIVKLKHFEKFQDTAEALAAFTALMEGKINKQLKKVLKKIVKEAHEPLAVA DAKLGGVIKEKLNLSCIHSPVVNELMRGIRSQMDGLIPGVEPREMAAMCLGLAHSLSRYRLKFSADKVDTMIVQAISSQNQERLCAFKDP YQQDLGIGESRISHENGTILCSKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCSTDLCNVNFTE NFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRKQGLHSMNMMEAAASEPSLDLDNLKLLELIGRGRYGAVYK GSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVT RGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCES ALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAE ARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHNRRVPKIGPYPDYSSSSYIEDSIHHTDSIVKNISSEHSMSSTPLTI GEKNRNSINYERQQAQARIPSPETSVTSLSTNTTTTNTTGLTPSTGMTTISEMPYPDETNLHTTNVAQSIGPTPVCLQLTEEDLETNKLD PKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEATGQQDFTQTANGQACLIPDVLPTQIYPLPKQQNLPKRPTSLP LNTKNSTKEPRLKFGSKHKSNLKQVETGVAKMNTINAAEPHVVTVTMNGVAGRNHSVNSHAATTQYANGTVLSGQTTNIVTHRAQEMLQN QFIGEDTRLNINSSPDEHEPLLRREQQAGHDEGVLDRLVDRRERPLEGGRTNSNNNNSNPCSEQDVLAQGVPSTAADPGPSKPRRAQRPN SLDLSATNVLDGSSIQIGESTQDGKSGSGEKIKKRVKTPYSLKRWRPSTWVISTESLDCEVNNNGSNRAVHSKSSTAVYLAEGGTATTMV -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for NOP58-BMPR2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for NOP58-BMPR2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for NOP58-BMPR2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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