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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NOS1AP-MROH9 (FusionGDB2 ID:59679)

Fusion Gene Summary for NOS1AP-MROH9

Fusion gene summary

Fusion gene information	Fusion gene name: NOS1AP-MROH9
	Fusion gene ID: 59679
		Hgene	Tgene
	Gene symbol	NOS1AP	MROH9
	Gene ID	9722	80133
	Gene name	nitric oxide synthase 1 adaptor protein	maestro heat like repeat family member 9
	Synonyms	6330408P19Rik\|CAPON	ARMC11\|C1orf129
	Cytomap	1q23.3	1q24.3
	Type of gene	protein-coding	protein-coding
	Description	carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase proteinC-terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON)C-terminal PDZ ligand of neuronal nitric oxide synthase proteinligand of neuronal nitric oxide synthase with car	maestro heat-like repeat-containing protein family member 9armadillo repeat containing 11
	Modification date	20200313	20200313
	UniProtAcc	O75052	.
	Ensembl transtripts involved in fusion gene	ENST00000361897, ENST00000530878, ENST00000454693, ENST00000493151,	ENST00000367758, ENST00000367759,
Fusion gene scores	* DoF score	15 X 9 X 8=1080	2 X 2 X 2=8
	# samples	18	2
	** MAII score	log2(18/1080*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: NOS1AP [Title/Abstract] AND MROH9 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NOS1AP(162302915)-MROH9(170983258), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NOS1AP	GO:0098974	postsynaptic actin cytoskeleton organization	26869880

Fusion gene breakpoints across NOS1AP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MROH9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A2-A0YG-01A	NOS1AP	chr1	162302915	+	MROH9	chr1	170983258	+

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Fusion Gene ORF analysis for NOS1AP-MROH9

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000361897	ENST00000367758	NOS1AP	chr1	162302915	+	MROH9	chr1	170983258	+
5CDS-intron	ENST00000530878	ENST00000367758	NOS1AP	chr1	162302915	+	MROH9	chr1	170983258	+
In-frame	ENST00000361897	ENST00000367759	NOS1AP	chr1	162302915	+	MROH9	chr1	170983258	+
In-frame	ENST00000530878	ENST00000367759	NOS1AP	chr1	162302915	+	MROH9	chr1	170983258	+
intron-3CDS	ENST00000454693	ENST00000367759	NOS1AP	chr1	162302915	+	MROH9	chr1	170983258	+
intron-3CDS	ENST00000493151	ENST00000367759	NOS1AP	chr1	162302915	+	MROH9	chr1	170983258	+
intron-intron	ENST00000454693	ENST00000367758	NOS1AP	chr1	162302915	+	MROH9	chr1	170983258	+
intron-intron	ENST00000493151	ENST00000367758	NOS1AP	chr1	162302915	+	MROH9	chr1	170983258	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000530878

NOS1AP

chr1

162302915

ENST00000367759

MROH9

chr1

170983258

2257

842

221

1831

536

ENST00000361897

NOS1AP

chr1

162302915

ENST00000367759

MROH9

chr1

170983258

2270

855

219

1844

541

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000530878	ENST00000367759	NOS1AP	chr1	162302915	+	MROH9	chr1	170983258	+	0.001583445	0.99841654
ENST00000361897	ENST00000367759	NOS1AP	chr1	162302915	+	MROH9	chr1	170983258	+	0.002707649	0.99729234

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Fusion Genomic Features for NOS1AP-MROH9

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
NOS1AP	chr1	162302915	+	MROH9	chr1	170983257	+	4.54E-06	0.99999547
NOS1AP	chr1	162302915	+	MROH9	chr1	170983257	+	4.54E-06	0.99999547

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NOS1AP-MROH9

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:162302915/chr1:170983258)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NOS1AP O75052	.
FUNCTION: Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MROH9

chr1:162302915

chr1:170983258

ENST00000367758

118_155

574.0

Repeat

Note=HEAT 1

Tgene

MROH9

chr1:162302915

chr1:170983258

ENST00000367758

252_289

574.0

Repeat

Note=HEAT 2

Tgene

MROH9

chr1:162302915

chr1:170983258

ENST00000367758

292_328

574.0

Repeat

Note=HEAT 3

Tgene

MROH9

chr1:162302915

chr1:170983258

ENST00000367758

357_394

574.0

Repeat

Note=HEAT 4

Tgene

MROH9

chr1:162302915

chr1:170983258

ENST00000367758

418_458

574.0

Repeat

Note=HEAT 5

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NOS1AP

chr1:162302915

chr1:170983258

ENST00000361897

322_363

151

507.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

NOS1AP

chr1:162302915

chr1:170983258

ENST00000493151

322_363

212.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

NOS1AP

chr1:162302915

chr1:170983258

ENST00000530878

322_363

146

502.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

NOS1AP

chr1:162302915

chr1:170983258

ENST00000361897

301_308

151

507.0

Compositional bias

Note=Poly-Gln

Hgene

NOS1AP

chr1:162302915

chr1:170983258

ENST00000493151

301_308

212.0

Compositional bias

Note=Poly-Gln

Hgene

NOS1AP

chr1:162302915

chr1:170983258

ENST00000530878

301_308

146

502.0

Compositional bias

Note=Poly-Gln

Hgene

NOS1AP

chr1:162302915

chr1:170983258

ENST00000361897

26_196

151

507.0

Domain

PID

Hgene

NOS1AP

chr1:162302915

chr1:170983258

ENST00000493151

26_196

212.0

Domain

PID

Hgene

NOS1AP

chr1:162302915

chr1:170983258

ENST00000530878

26_196

146

502.0

Domain

PID

Hgene

NOS1AP

chr1:162302915

chr1:170983258

ENST00000361897

504_506

151

507.0

Motif

PDZ-binding

Hgene

NOS1AP

chr1:162302915

chr1:170983258

ENST00000493151

504_506

212.0

Motif

PDZ-binding

Hgene

NOS1AP

chr1:162302915

chr1:170983258

ENST00000530878

504_506

146

502.0

Motif

PDZ-binding

Tgene

MROH9

chr1:162302915

chr1:170983258

ENST00000367759

118_155

532

862.0

Repeat

Note=HEAT 1

Tgene

MROH9

chr1:162302915

chr1:170983258

ENST00000367759

252_289

532

862.0

Repeat

Note=HEAT 2

Tgene

MROH9

chr1:162302915

chr1:170983258

ENST00000367759

292_328

532

862.0

Repeat

Note=HEAT 3

Tgene

MROH9

chr1:162302915

chr1:170983258

ENST00000367759

357_394

532

862.0

Repeat

Note=HEAT 4

Tgene

MROH9

chr1:162302915

chr1:170983258

ENST00000367759

418_458

532

862.0

Repeat

Note=HEAT 5

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Fusion Gene Sequence for NOS1AP-MROH9

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>59679_59679_1_NOS1AP-MROH9_NOS1AP_chr1_162302915_ENST00000361897_MROH9_chr1_170983258_ENST00000367759_length(transcript)=2270nt_BP=855nt
CGTCGCCTTTTCTTCTTCGTCCCGGGCGGTGCGTTCCACTGCTCTGGGGCCGGCGCCGCGCCCAGTCCCGCTTCGGGCCGCAAGCCCCAC
CGCTCCCCTCCCCGGGCAGGGGCGCCGCGCAGCCCGCTCCCGCCGCCACCTCCTCCCCTGCCGCCCTCCTAGCCGGCAGGAATTGCGCGA
CCACAGCGCCGCTCGCGTCGCCCGCATCAGCTCAGCCCGCTGCCGCTCGGCCCTCGGCACCGCTCCGGGTCCGGCCGCCGCGCGGCCAGG
GCTCCCCCTGCCCAGCGCTCCCAGGCCCCGCCACGCGTCGCCGCGCCCAGCTCCAGTCTCCCCTCCCCGGGGTCTCGCCAGCCCCTTCCT
GCAGCCGCCGCCTCCGAAGGAGCGGGTCCGCCGCGGGTAACCATGCCTAGCAAAACCAAGTACAACCTTGTGGACGATGGGCACGACCTG
CGGATCCCCTTGCACAACGAGGACGCCTTCCAGCACGGCATCTGCTTTGAGGCCAAGTACGTAGGAAGCCTGGACGTGCCAAGGCCCAAC
AGCAGGGTGGAGATCGTGGCTGCCATGCGCCGGATACGGTATGAGTTTAAAGCCAAGAACATCAAGAAGAAGAAAGTGAGCATTATGGTT
TCAGTGGATGGAGTGAAAGTGATTCTGAAGAAGAAGAAAAAGCTTCTTTTATTGCAGAAAAAGGAATGGACGTGGGATGAGAGCAAGATG
CTGGTGATGCAGGACCCCATCTACAGGATCTTCTATGTCTCTCATGATTCCCAAGACTTGAAGATCTTCAGCTATATCGCTCGAGATGGT
GCCAGCAATATCTTCAGGTGTAACGTCTTTAAATCCAAGAAGAAGCTTCTGAATAACTTCTTCAAGGACCCTTTACCAGAAGAATTTTTG
GTCCTCTTCATAAACTGGATCAATGATTCCAATCCTGTAGTTAGCAGACTGATCCTTCATAGAATTGTCCACATGTCACCAATTATCAAT
AAGACAGAAAATGTCAGCAGTATATTAATAGCCATCCTGGATGCCTTCCTTTCCAAAGACGATAATGTTGTACTTCAGGCCTTGCTCACC
CTTAGAAGGCTTTTAAACGAACTGGACAAAGTGACCTACTCTTTGGGTACCAGAATTGGTTCCAGCTACTGTACTCTGATGGATCATATT
AATGGAGGCATTCGAAGTATGGCAATTCGACACTTTGGTCAATTAGTTAGGGATATGAGACAGTACACATGGATGGTGAATGATGTGGTT
CTAGAAGGCTTGGTGCCCCTAATCCTATTTTTGGAGGATGATGATAAAAGAGTAGCTGAAGCATGTAAATATACATTAAAAATCTGTACC
TCACAATTAAAGTGGTCAACATCACGTTTGCTCAAAGATGAAAATTACAGTTTTGAGATGGTGGTGCTCAATATCTGTAACAATCTTATT
ATTTCTCATAGGAACTACATTACAGATTTGACATCTGATACCTTACGATTCCTGTGGAGCCCCAGAACATATCTTAAGAGGGCATCGGTT
ATTTTGATAGGATATTTGGCAAAATCAGGTGGTCATTTACTGCTTAGAGATGAAATCGAAGTCATGCTTGATGTTATTGAACGACTGCTC
CGAGATGAAGACCCTATGATCAAACAGTTGGCTGAAATAACCTATGATATTTTTAAGAAAAAAGCCCATAAACTGACCTCTGCACCTCTT
AAACAAAACTTCCAAAAATTGCTTAAATTATTCTACATCAAAAAATTGAAGCCTCTTTACAATTATAACTCACCCAATGGCCAGATAGAC
AGTCCTACAGACAGTAAAGATGTCAAGAATGATAAGGCCTTATAGAAGAGAATGATGATGACATTCATCATTCATAAACAATGGGAAGTC
CAACAATGTCTTGGAGCTGACCTTAGAAGAAGAATGATTTTTCTTTCCCTCCTGACAACTTGAGTCTGTTTGTAGATGCTTTTCTGAAAA
ATTCTGGAAGCTTTTACTGTTACTTCTTAATTCTCTATTCAAATATAGAAATCTGAGAGAACTAGTGCCTCTGTATGTCTGACAGTGATC
AGAAGCCCTATTTCATCAAAACCACTAAGACAATTGAAAATAACATAAGCAAAGTGTTTGATGAGAAGCTCTGGGAACTTGATTCAGTCC
GGAAGCTCTACTGAGCACCTTCTAAGTGCCAGATACTGTGTTAGGCAGTGGGGACATTTGGATGATATAGACAAGGTTCCTGATCTCAGG

>59679_59679_1_NOS1AP-MROH9_NOS1AP_chr1_162302915_ENST00000361897_MROH9_chr1_170983258_ENST00000367759_length(amino acids)=541AA_BP=212
MPLGPRHRSGSGRRAARAPPAQRSQAPPRVAAPSSSLPSPGSRQPLPAAAASEGAGPPRVTMPSKTKYNLVDDGHDLRIPLHNEDAFQHG
ICFEAKYVGSLDVPRPNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKKLLLLQKKEWTWDESKMLVMQDPIYRIFYV
SHDSQDLKIFSYIARDGASNIFRCNVFKSKKKLLNNFFKDPLPEEFLVLFINWINDSNPVVSRLILHRIVHMSPIINKTENVSSILIAIL
DAFLSKDDNVVLQALLTLRRLLNELDKVTYSLGTRIGSSYCTLMDHINGGIRSMAIRHFGQLVRDMRQYTWMVNDVVLEGLVPLILFLED
DDKRVAEACKYTLKICTSQLKWSTSRLLKDENYSFEMVVLNICNNLIISHRNYITDLTSDTLRFLWSPRTYLKRASVILIGYLAKSGGHL
LLRDEIEVMLDVIERLLRDEDPMIKQLAEITYDIFKKKAHKLTSAPLKQNFQKLLKLFYIKKLKPLYNYNSPNGQIDSPTDSKDVKNDKA

--------------------------------------------------------------
>59679_59679_2_NOS1AP-MROH9_NOS1AP_chr1_162302915_ENST00000530878_MROH9_chr1_170983258_ENST00000367759_length(transcript)=2257nt_BP=842nt
ACCGTCGCCTTTTCTTCTTCGTCCCGGGCGGTGCGTTCCACTGCTCTGGGGCCGGCGCCGCGCCCAGTCCCGCTTCGGGCCGCAAGCCCC
ACCGCTCCCCTCCCCGGGCAGGGGCGCCGCGCAGCCCGCTCCCGCCGCCACCTCCTCCCCTGCCGCCCTCCTAGCCGGCAGGAATTGCGC
GACCACAGCGCCGCTCGCGTCGCCCGCATCAGCTCAGCCCGCTGCCGCTCGGCCCTCGGCACCGCTCCGGGTCCGGCCGCCGCGCGGCCA
GGGCTCCCCCTGCCCAGCGCTCCCAGGCCCCGCCACGCGTCGCCGCGCCCAGCTCCAGTCTCCCCTCCCCGGGGTCTCGCCAGCCCCTTC
CTGCAGCCGCCGCCTCCGAAGGAGCGGGTCCGCCGCGGGTAACCATGCCTAGCAAAACCAAGTACAACCTTGTGGACGATGGGCACGACC
TGCGGATCCCCTTGCACAACGAGGACGCCTTCCAGCACGGCATCTGCTTTGAGGCCAAGTACGTAGGAAGCCTGGACGTGCCAAGGCCCA
ACAGCAGGGTGGAGATCGTGGCTGCCATGCGCCGGATACGGTATGAGTTTAAAGCCAAGAACATCAAGAAGAAGAAAGTGAGCATTATGG
TTTCAGTGGATGGAGTGAAAGTGATTCTGAAGAAGAAGAAAAAGAAAAAGGAATGGACGTGGGATGAGAGCAAGATGCTGGTGATGCAGG
ACCCCATCTACAGGATCTTCTATGTCTCTCATGATTCCCAAGACTTGAAGATCTTCAGCTATATCGCTCGAGATGGTGCCAGCAATATCT
TCAGGTGTAACGTCTTTAAATCCAAGAAGAAGCTTCTGAATAACTTCTTCAAGGACCCTTTACCAGAAGAATTTTTGGTCCTCTTCATAA
ACTGGATCAATGATTCCAATCCTGTAGTTAGCAGACTGATCCTTCATAGAATTGTCCACATGTCACCAATTATCAATAAGACAGAAAATG
TCAGCAGTATATTAATAGCCATCCTGGATGCCTTCCTTTCCAAAGACGATAATGTTGTACTTCAGGCCTTGCTCACCCTTAGAAGGCTTT
TAAACGAACTGGACAAAGTGACCTACTCTTTGGGTACCAGAATTGGTTCCAGCTACTGTACTCTGATGGATCATATTAATGGAGGCATTC
GAAGTATGGCAATTCGACACTTTGGTCAATTAGTTAGGGATATGAGACAGTACACATGGATGGTGAATGATGTGGTTCTAGAAGGCTTGG
TGCCCCTAATCCTATTTTTGGAGGATGATGATAAAAGAGTAGCTGAAGCATGTAAATATACATTAAAAATCTGTACCTCACAATTAAAGT
GGTCAACATCACGTTTGCTCAAAGATGAAAATTACAGTTTTGAGATGGTGGTGCTCAATATCTGTAACAATCTTATTATTTCTCATAGGA
ACTACATTACAGATTTGACATCTGATACCTTACGATTCCTGTGGAGCCCCAGAACATATCTTAAGAGGGCATCGGTTATTTTGATAGGAT
ATTTGGCAAAATCAGGTGGTCATTTACTGCTTAGAGATGAAATCGAAGTCATGCTTGATGTTATTGAACGACTGCTCCGAGATGAAGACC
CTATGATCAAACAGTTGGCTGAAATAACCTATGATATTTTTAAGAAAAAAGCCCATAAACTGACCTCTGCACCTCTTAAACAAAACTTCC
AAAAATTGCTTAAATTATTCTACATCAAAAAATTGAAGCCTCTTTACAATTATAACTCACCCAATGGCCAGATAGACAGTCCTACAGACA
GTAAAGATGTCAAGAATGATAAGGCCTTATAGAAGAGAATGATGATGACATTCATCATTCATAAACAATGGGAAGTCCAACAATGTCTTG
GAGCTGACCTTAGAAGAAGAATGATTTTTCTTTCCCTCCTGACAACTTGAGTCTGTTTGTAGATGCTTTTCTGAAAAATTCTGGAAGCTT
TTACTGTTACTTCTTAATTCTCTATTCAAATATAGAAATCTGAGAGAACTAGTGCCTCTGTATGTCTGACAGTGATCAGAAGCCCTATTT
CATCAAAACCACTAAGACAATTGAAAATAACATAAGCAAAGTGTTTGATGAGAAGCTCTGGGAACTTGATTCAGTCCGGAAGCTCTACTG
AGCACCTTCTAAGTGCCAGATACTGTGTTAGGCAGTGGGGACATTTGGATGATATAGACAAGGTTCCTGATCTCAGGATGGGCACAGTCT

>59679_59679_2_NOS1AP-MROH9_NOS1AP_chr1_162302915_ENST00000530878_MROH9_chr1_170983258_ENST00000367759_length(amino acids)=536AA_BP=207
MPLGPRHRSGSGRRAARAPPAQRSQAPPRVAAPSSSLPSPGSRQPLPAAAASEGAGPPRVTMPSKTKYNLVDDGHDLRIPLHNEDAFQHG
ICFEAKYVGSLDVPRPNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKKKKEWTWDESKMLVMQDPIYRIFYVSHDSQ
DLKIFSYIARDGASNIFRCNVFKSKKKLLNNFFKDPLPEEFLVLFINWINDSNPVVSRLILHRIVHMSPIINKTENVSSILIAILDAFLS
KDDNVVLQALLTLRRLLNELDKVTYSLGTRIGSSYCTLMDHINGGIRSMAIRHFGQLVRDMRQYTWMVNDVVLEGLVPLILFLEDDDKRV
AEACKYTLKICTSQLKWSTSRLLKDENYSFEMVVLNICNNLIISHRNYITDLTSDTLRFLWSPRTYLKRASVILIGYLAKSGGHLLLRDE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NOS1AP-MROH9

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	NOS1AP	chr1:162302915	chr1:170983258	ENST00000361897	+	5	10	494_506	151.0	507.0	NOS1
Hgene	NOS1AP	chr1:162302915	chr1:170983258	ENST00000493151	+	1	2	494_506	0	212.0	NOS1
Hgene	NOS1AP	chr1:162302915	chr1:170983258	ENST00000530878	+	5	10	494_506	146.0	502.0	NOS1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for NOS1AP-MROH9

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for NOS1AP-MROH9

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source