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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NOSTRIN-NOX5 (FusionGDB2 ID:59698)

Fusion Gene Summary for NOSTRIN-NOX5

check button Fusion gene summary
Fusion gene informationFusion gene name: NOSTRIN-NOX5
Fusion gene ID: 59698
HgeneTgene
Gene symbol

NOSTRIN

NOX5

Gene ID

115677

79400

Gene namenitric oxide synthase traffickingNADPH oxidase 5
SynonymsDaIP2-
Cytomap

2q24.3

15q23

Type of geneprotein-codingprotein-coding
DescriptionnostrinBM247 homologENOS traffic inducereNOS-trafficking inducerendothelial nitric oxide synthase traffic inducernitric oxide synthase traffic inducernitric oxide synthase traffickerortholog of mouse disabled 2 interacting proein 2NADPH oxidase 5NADPH oxidase, EF-hand calcium binding domain 5
Modification date2020031320200322
UniProtAcc.

Q96PH1

Ensembl transtripts involved in fusion geneENST00000317647, ENST00000397209, 
ENST00000421711, ENST00000444448, 
ENST00000458381, ENST00000397206, 
ENST00000445023, 		ENST00000525163, 
ENST00000260364, ENST00000388866, 
ENST00000448182, ENST00000455873, 
ENST00000530406, 
Fusion gene scores* DoF score3 X 2 X 3=185 X 6 X 5=150
# samples 36
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NOSTRIN [Title/Abstract] AND NOX5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNOSTRIN(169659183)-NOX5(69347674), # samples:1
Anticipated loss of major functional domain due to fusion event.NOSTRIN-NOX5 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNOX5

GO:0001935

endothelial cell proliferation

17275676

TgeneNOX5

GO:0042554

superoxide anion generation

11483596

TgeneNOX5

GO:0055114

oxidation-reduction process

11483596

TgeneNOX5

GO:1902600

proton transmembrane transport

11483596


check buttonFusion gene breakpoints across NOSTRIN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NOX5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5K2-01ANOSTRINchr2

169659183

+NOX5chr15

69347674

+


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Fusion Gene ORF analysis for NOSTRIN-NOX5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000317647ENST00000525163NOSTRINchr2

169659183

+NOX5chr15

69347674

+
5CDS-intronENST00000397209ENST00000525163NOSTRINchr2

169659183

+NOX5chr15

69347674

+
5CDS-intronENST00000421711ENST00000525163NOSTRINchr2

169659183

+NOX5chr15

69347674

+
5CDS-intronENST00000444448ENST00000525163NOSTRINchr2

169659183

+NOX5chr15

69347674

+
5CDS-intronENST00000458381ENST00000525163NOSTRINchr2

169659183

+NOX5chr15

69347674

+
5UTR-3CDSENST00000397206ENST00000260364NOSTRINchr2

169659183

+NOX5chr15

69347674

+
5UTR-3CDSENST00000397206ENST00000388866NOSTRINchr2

169659183

+NOX5chr15

69347674

+
5UTR-3CDSENST00000397206ENST00000448182NOSTRINchr2

169659183

+NOX5chr15

69347674

+
5UTR-3CDSENST00000397206ENST00000455873NOSTRINchr2

169659183

+NOX5chr15

69347674

+
5UTR-3CDSENST00000397206ENST00000530406NOSTRINchr2

169659183

+NOX5chr15

69347674

+
5UTR-3CDSENST00000445023ENST00000260364NOSTRINchr2

169659183

+NOX5chr15

69347674

+
5UTR-3CDSENST00000445023ENST00000388866NOSTRINchr2

169659183

+NOX5chr15

69347674

+
5UTR-3CDSENST00000445023ENST00000448182NOSTRINchr2

169659183

+NOX5chr15

69347674

+
5UTR-3CDSENST00000445023ENST00000455873NOSTRINchr2

169659183

+NOX5chr15

69347674

+
5UTR-3CDSENST00000445023ENST00000530406NOSTRINchr2

169659183

+NOX5chr15

69347674

+
5UTR-intronENST00000397206ENST00000525163NOSTRINchr2

169659183

+NOX5chr15

69347674

+
5UTR-intronENST00000445023ENST00000525163NOSTRINchr2

169659183

+NOX5chr15

69347674

+
Frame-shiftENST00000317647ENST00000260364NOSTRINchr2

169659183

+NOX5chr15

69347674

+
Frame-shiftENST00000317647ENST00000388866NOSTRINchr2

169659183

+NOX5chr15

69347674

+
Frame-shiftENST00000317647ENST00000448182NOSTRINchr2

169659183

+NOX5chr15

69347674

+
Frame-shiftENST00000317647ENST00000455873NOSTRINchr2

169659183

+NOX5chr15

69347674

+
Frame-shiftENST00000317647ENST00000530406NOSTRINchr2

169659183

+NOX5chr15

69347674

+
Frame-shiftENST00000397209ENST00000260364NOSTRINchr2

169659183

+NOX5chr15

69347674

+
Frame-shiftENST00000397209ENST00000388866NOSTRINchr2

169659183

+NOX5chr15

69347674

+
Frame-shiftENST00000397209ENST00000448182NOSTRINchr2

169659183

+NOX5chr15

69347674

+
Frame-shiftENST00000397209ENST00000455873NOSTRINchr2

169659183

+NOX5chr15

69347674

+
Frame-shiftENST00000397209ENST00000530406NOSTRINchr2

169659183

+NOX5chr15

69347674

+
Frame-shiftENST00000421711ENST00000260364NOSTRINchr2

169659183

+NOX5chr15

69347674

+
Frame-shiftENST00000421711ENST00000388866NOSTRINchr2

169659183

+NOX5chr15

69347674

+
Frame-shiftENST00000421711ENST00000448182NOSTRINchr2

169659183

+NOX5chr15

69347674

+
Frame-shiftENST00000421711ENST00000455873NOSTRINchr2

169659183

+NOX5chr15

69347674

+
Frame-shiftENST00000421711ENST00000530406NOSTRINchr2

169659183

+NOX5chr15

69347674

+
Frame-shiftENST00000444448ENST00000260364NOSTRINchr2

169659183

+NOX5chr15

69347674

+
Frame-shiftENST00000444448ENST00000388866NOSTRINchr2

169659183

+NOX5chr15

69347674

+
Frame-shiftENST00000444448ENST00000448182NOSTRINchr2

169659183

+NOX5chr15

69347674

+
Frame-shiftENST00000444448ENST00000455873NOSTRINchr2

169659183

+NOX5chr15

69347674

+
Frame-shiftENST00000444448ENST00000530406NOSTRINchr2

169659183

+NOX5chr15

69347674

+
Frame-shiftENST00000458381ENST00000260364NOSTRINchr2

169659183

+NOX5chr15

69347674

+
Frame-shiftENST00000458381ENST00000388866NOSTRINchr2

169659183

+NOX5chr15

69347674

+
Frame-shiftENST00000458381ENST00000448182NOSTRINchr2

169659183

+NOX5chr15

69347674

+
Frame-shiftENST00000458381ENST00000455873NOSTRINchr2

169659183

+NOX5chr15

69347674

+
Frame-shiftENST00000458381ENST00000530406NOSTRINchr2

169659183

+NOX5chr15

69347674

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NOSTRIN-NOX5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NOSTRINchr2169659183+NOX5chr1569347673+4.32E-070.9999995
NOSTRINchr2169659183+NOX5chr1569347673+4.32E-070.9999995

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NOSTRIN-NOX5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:169659183/:69347674)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NOX5

Q96PH1

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin. {ECO:0000269|PubMed:11483596, ECO:0000269|PubMed:12686516, ECO:0000269|PubMed:17275676}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NOSTRIN-NOX5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NOSTRIN-NOX5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NOSTRIN-NOX5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NOSTRIN-NOX5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource