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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:NOTCH1-LZTR1 (FusionGDB2 ID:59711) |
Fusion Gene Summary for NOTCH1-LZTR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NOTCH1-LZTR1 | Fusion gene ID: 59711 | Hgene | Tgene | Gene symbol | NOTCH1 | LZTR1 | Gene ID | 4851 | 8216 |
| Gene name | notch receptor 1 | leucine zipper like transcription regulator 1 | |
| Synonyms | AOS5|AOVD1|TAN1|hN1 | BTBD29|LZTR-1|NS10|NS2|SWNTS2 | |
| Cytomap | 9q34.3 | 22q11.21|22q11.1-q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | neurogenic locus notch homolog protein 1Notch homolog 1, translocation-associatednotch 1translocation-associated notch protein TAN-1 | leucine-zipper-like transcriptional regulator 1epididymis secretory sperm binding protein | |
| Modification date | 20200329 | 20200327 | |
| UniProtAcc | P46531 | Q8N653 | |
| Ensembl transtripts involved in fusion gene | ENST00000277541, ENST00000491649, | ENST00000215739, ENST00000389355, ENST00000479606, | |
| Fusion gene scores | * DoF score | 22 X 18 X 15=5940 | 5 X 8 X 5=200 |
| # samples | 24 | 6 | |
| ** MAII score | log2(24/5940*10)=-4.62935662007961 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/200*10)=-1.73696559416621 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NOTCH1 [Title/Abstract] AND LZTR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | NOTCH1(139396724)-LZTR1(21351521), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NOTCH1 | GO:0007050 | cell cycle arrest | 11306509 |
| Hgene | NOTCH1 | GO:0007219 | Notch signaling pathway | 11306509 |
| Hgene | NOTCH1 | GO:0008284 | positive regulation of cell proliferation | 17849174 |
| Hgene | NOTCH1 | GO:0008285 | negative regulation of cell proliferation | 11306509|20616313 |
| Hgene | NOTCH1 | GO:0010629 | negative regulation of gene expression | 11306509 |
| Hgene | NOTCH1 | GO:0010812 | negative regulation of cell-substrate adhesion | 16501043 |
| Hgene | NOTCH1 | GO:0035924 | cellular response to vascular endothelial growth factor stimulus | 20616313 |
| Hgene | NOTCH1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 20616313 |
| Hgene | NOTCH1 | GO:0045967 | negative regulation of growth rate | 11306509 |
| Hgene | NOTCH1 | GO:0046579 | positive regulation of Ras protein signal transduction | 11306509 |
| Hgene | NOTCH1 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 11306509 |
| Hgene | NOTCH1 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus | 20613903 |
| Hgene | NOTCH1 | GO:0090051 | negative regulation of cell migration involved in sprouting angiogenesis | 20616313 |
| Hgene | NOTCH1 | GO:2001027 | negative regulation of endothelial cell chemotaxis | 20616313 |
| Tgene | LZTR1 | GO:0016567 | protein ubiquitination | 30442762|30442766 |
| Tgene | LZTR1 | GO:0046580 | negative regulation of Ras protein signal transduction | 30442762|30442766 |
| Fusion gene breakpoints across NOTCH1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across LZTR1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | GBM | TCGA-28-5209-01A | NOTCH1 | chr9 | 139396724 | - | LZTR1 | chr22 | 21351521 | + |
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Fusion Gene ORF analysis for NOTCH1-LZTR1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000277541 | ENST00000215739 | NOTCH1 | chr9 | 139396724 | - | LZTR1 | chr22 | 21351521 | + |
| 5CDS-3UTR | ENST00000277541 | ENST00000389355 | NOTCH1 | chr9 | 139396724 | - | LZTR1 | chr22 | 21351521 | + |
| 5CDS-3UTR | ENST00000277541 | ENST00000479606 | NOTCH1 | chr9 | 139396724 | - | LZTR1 | chr22 | 21351521 | + |
| intron-3UTR | ENST00000491649 | ENST00000215739 | NOTCH1 | chr9 | 139396724 | - | LZTR1 | chr22 | 21351521 | + |
| intron-3UTR | ENST00000491649 | ENST00000389355 | NOTCH1 | chr9 | 139396724 | - | LZTR1 | chr22 | 21351521 | + |
| intron-3UTR | ENST00000491649 | ENST00000479606 | NOTCH1 | chr9 | 139396724 | - | LZTR1 | chr22 | 21351521 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for NOTCH1-LZTR1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| NOTCH1 | chr9 | 139396723 | - | LZTR1 | chr22 | 21351520 | + | 0.0009608 | 0.9990392 |
| NOTCH1 | chr9 | 139396723 | - | LZTR1 | chr22 | 21351520 | + | 0.0009608 | 0.9990392 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for NOTCH1-LZTR1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:139396724/:21351521) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NOTCH1 | LZTR1 |
| FUNCTION: Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). {ECO:0000269|PubMed:20616313}. | FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS) (PubMed:30442762, PubMed:30442766, PubMed:30481304). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes (PubMed:30442762, PubMed:30442766, PubMed:30481304). {ECO:0000269|PubMed:30442762, ECO:0000269|PubMed:30442766, ECO:0000269|PubMed:30481304}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for NOTCH1-LZTR1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for NOTCH1-LZTR1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for NOTCH1-LZTR1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for NOTCH1-LZTR1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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