Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NOTCH1-SDCCAG3 (FusionGDB2 ID:59715)

Fusion Gene Summary for NOTCH1-SDCCAG3

Fusion gene summary

Fusion gene information	Fusion gene name: NOTCH1-SDCCAG3
	Fusion gene ID: 59715
		Hgene	Tgene
	Gene symbol	NOTCH1	SDCCAG3
	Gene ID	4851	10807
	Gene name	notch receptor 1	endosome associated trafficking regulator 1
	Synonyms	AOS5\|AOVD1\|TAN1\|hN1	NY-CO-3\|SDCCAG3\|SDDAG3
	Cytomap	9q34.3	9q34.3
	Type of gene	protein-coding	protein-coding
	Description	neurogenic locus notch homolog protein 1Notch homolog 1, translocation-associatednotch 1translocation-associated notch protein TAN-1	endosome-associated-trafficking regulator 1antigen NY-CO-3serologically defined colon cancer antigen 3
	Modification date	20200329	20200313
	UniProtAcc	P46531	.
	Ensembl transtripts involved in fusion gene	ENST00000277541, ENST00000491649,	ENST00000461693, ENST00000298537, ENST00000357365, ENST00000371725,
Fusion gene scores	* DoF score	22 X 18 X 15=5940	5 X 6 X 4=120
	# samples	24	8
	** MAII score	log2(24/5940*10)=-4.62935662007961 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/120*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NOTCH1 [Title/Abstract] AND SDCCAG3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NOTCH1(139438476)-SDCCAG3(139302390), # samples:2 NOTCH1(139402407)-SDCCAG3(139300430), # samples:2
Anticipated loss of major functional domain due to fusion event.	NOTCH1-SDCCAG3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. NOTCH1-SDCCAG3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. NOTCH1-SDCCAG3 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NOTCH1	GO:0007050	cell cycle arrest	11306509
Hgene	NOTCH1	GO:0007219	Notch signaling pathway	11306509
Hgene	NOTCH1	GO:0008284	positive regulation of cell proliferation	17849174
Hgene	NOTCH1	GO:0008285	negative regulation of cell proliferation	11306509\|20616313
Hgene	NOTCH1	GO:0010629	negative regulation of gene expression	11306509
Hgene	NOTCH1	GO:0010812	negative regulation of cell-substrate adhesion	16501043
Hgene	NOTCH1	GO:0035924	cellular response to vascular endothelial growth factor stimulus	20616313
Hgene	NOTCH1	GO:0045944	positive regulation of transcription by RNA polymerase II	20616313
Hgene	NOTCH1	GO:0045967	negative regulation of growth rate	11306509
Hgene	NOTCH1	GO:0046579	positive regulation of Ras protein signal transduction	11306509
Hgene	NOTCH1	GO:0070374	positive regulation of ERK1 and ERK2 cascade	11306509
Hgene	NOTCH1	GO:0071372	cellular response to follicle-stimulating hormone stimulus	20613903
Hgene	NOTCH1	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	20616313
Hgene	NOTCH1	GO:2001027	negative regulation of endothelial cell chemotaxis	20616313
Tgene	SDCCAG3	GO:0032465	regulation of cytokinesis	23108400

Fusion gene breakpoints across NOTCH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SDCCAG3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-BB-4224-01A	NOTCH1	chr9	139438476	-	SDCCAG3	chr9	139302390	-
ChimerDB4	HNSC	TCGA-BB-4224	NOTCH1	chr9	139438475	-	SDCCAG3	chr9	139302390	-
ChimerDB4	HNSC	TCGA-BB-4224	NOTCH1	chr9	139438476	-	SDCCAG3	chr9	139302390	-
ChimerDB4	HNSC	TCGA-CN-5373	NOTCH1	chr9	139411724	-	SDCCAG3	chr9	139297339	-
ChimerDB4	LGG	TCGA-DU-7014-01A	NOTCH1	chr9	139402407	-	SDCCAG3	chr9	139300430	-
ChimerDB4	LGG	TCGA-DU-7014	NOTCH1	chr9	139402407	-	SDCCAG3	chr9	139300430	-

Top

Fusion Gene ORF analysis for NOTCH1-SDCCAG3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000277541	ENST00000461693	NOTCH1	chr9	139411724	-	SDCCAG3	chr9	139297339	-
5CDS-intron	ENST00000277541	ENST00000461693	NOTCH1	chr9	139438476	-	SDCCAG3	chr9	139302390	-
5CDS-intron	ENST00000277541	ENST00000461693	NOTCH1	chr9	139438475	-	SDCCAG3	chr9	139302390	-
5CDS-intron	ENST00000277541	ENST00000461693	NOTCH1	chr9	139402407	-	SDCCAG3	chr9	139300430	-
Frame-shift	ENST00000277541	ENST00000298537	NOTCH1	chr9	139438476	-	SDCCAG3	chr9	139302390	-
Frame-shift	ENST00000277541	ENST00000298537	NOTCH1	chr9	139438475	-	SDCCAG3	chr9	139302390	-
Frame-shift	ENST00000277541	ENST00000298537	NOTCH1	chr9	139411724	-	SDCCAG3	chr9	139297339	-
Frame-shift	ENST00000277541	ENST00000357365	NOTCH1	chr9	139438476	-	SDCCAG3	chr9	139302390	-
Frame-shift	ENST00000277541	ENST00000357365	NOTCH1	chr9	139438475	-	SDCCAG3	chr9	139302390	-
Frame-shift	ENST00000277541	ENST00000357365	NOTCH1	chr9	139411724	-	SDCCAG3	chr9	139297339	-
Frame-shift	ENST00000277541	ENST00000371725	NOTCH1	chr9	139438476	-	SDCCAG3	chr9	139302390	-
Frame-shift	ENST00000277541	ENST00000371725	NOTCH1	chr9	139438475	-	SDCCAG3	chr9	139302390	-
Frame-shift	ENST00000277541	ENST00000371725	NOTCH1	chr9	139411724	-	SDCCAG3	chr9	139297339	-
In-frame	ENST00000277541	ENST00000298537	NOTCH1	chr9	139402407	-	SDCCAG3	chr9	139300430	-
In-frame	ENST00000277541	ENST00000357365	NOTCH1	chr9	139402407	-	SDCCAG3	chr9	139300430	-
In-frame	ENST00000277541	ENST00000371725	NOTCH1	chr9	139402407	-	SDCCAG3	chr9	139300430	-
intron-3CDS	ENST00000491649	ENST00000298537	NOTCH1	chr9	139438476	-	SDCCAG3	chr9	139302390	-
intron-3CDS	ENST00000491649	ENST00000298537	NOTCH1	chr9	139438475	-	SDCCAG3	chr9	139302390	-
intron-3CDS	ENST00000491649	ENST00000298537	NOTCH1	chr9	139411724	-	SDCCAG3	chr9	139297339	-
intron-3CDS	ENST00000491649	ENST00000298537	NOTCH1	chr9	139402407	-	SDCCAG3	chr9	139300430	-
intron-3CDS	ENST00000491649	ENST00000357365	NOTCH1	chr9	139438476	-	SDCCAG3	chr9	139302390	-
intron-3CDS	ENST00000491649	ENST00000357365	NOTCH1	chr9	139438475	-	SDCCAG3	chr9	139302390	-
intron-3CDS	ENST00000491649	ENST00000357365	NOTCH1	chr9	139411724	-	SDCCAG3	chr9	139297339	-
intron-3CDS	ENST00000491649	ENST00000357365	NOTCH1	chr9	139402407	-	SDCCAG3	chr9	139300430	-
intron-3CDS	ENST00000491649	ENST00000371725	NOTCH1	chr9	139438476	-	SDCCAG3	chr9	139302390	-
intron-3CDS	ENST00000491649	ENST00000371725	NOTCH1	chr9	139438475	-	SDCCAG3	chr9	139302390	-
intron-3CDS	ENST00000491649	ENST00000371725	NOTCH1	chr9	139411724	-	SDCCAG3	chr9	139297339	-
intron-3CDS	ENST00000491649	ENST00000371725	NOTCH1	chr9	139402407	-	SDCCAG3	chr9	139300430	-
intron-5UTR	ENST00000491649	ENST00000461693	NOTCH1	chr9	139411724	-	SDCCAG3	chr9	139297339	-
intron-intron	ENST00000491649	ENST00000461693	NOTCH1	chr9	139438476	-	SDCCAG3	chr9	139302390	-
intron-intron	ENST00000491649	ENST00000461693	NOTCH1	chr9	139438475	-	SDCCAG3	chr9	139302390	-
intron-intron	ENST00000491649	ENST00000461693	NOTCH1	chr9	139402407	-	SDCCAG3	chr9	139300430	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000277541	NOTCH1	chr9	139402407	-	ENST00000357365	SDCCAG3	chr9	139300430	-	4938	3586	76	4074	1332
ENST00000277541	NOTCH1	chr9	139402407	-	ENST00000298537	SDCCAG3	chr9	139300430	-	4938	3586	76	4074	1332
ENST00000277541	NOTCH1	chr9	139402407	-	ENST00000371725	SDCCAG3	chr9	139300430	-	4912	3586	76	4074	1332

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000277541	ENST00000357365	NOTCH1	chr9	139402407	-	SDCCAG3	chr9	139300430	-	0.003561747	0.99643826
ENST00000277541	ENST00000298537	NOTCH1	chr9	139402407	-	SDCCAG3	chr9	139300430	-	0.003561747	0.99643826
ENST00000277541	ENST00000371725	NOTCH1	chr9	139402407	-	SDCCAG3	chr9	139300430	-	0.003782319	0.99621767

Top

Fusion Genomic Features for NOTCH1-SDCCAG3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for NOTCH1-SDCCAG3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:139438476/chr9:139302390)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NOTCH1 P46531	.
FUNCTION: Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). {ECO:0000269\|PubMed:20616313}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

1021_1057

1170

2556.0

Domain

EGF-like 27

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

102_139

1170

2556.0

Domain

EGF-like 3

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

1059_1095

1170

2556.0

Domain

EGF-like 28

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

1097_1143

1170

2556.0

Domain

EGF-like 29

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

140_176

1170

2556.0

Domain

EGF-like 4

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

178_216

1170

2556.0

Domain

EGF-like 5%3B calcium-binding

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

20_58

1170

2556.0

Domain

EGF-like 1

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

218_255

1170

2556.0

Domain

EGF-like 6

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

257_293

1170

2556.0

Domain

EGF-like 7%3B calcium-binding

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

295_333

1170

2556.0

Domain

EGF-like 8%3B calcium-binding

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

335_371

1170

2556.0

Domain

EGF-like 9%3B calcium-binding

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

372_410

1170

2556.0

Domain

EGF-like 10

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

412_450

1170

2556.0

Domain

EGF-like 11%3B calcium-binding

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

452_488

1170

2556.0

Domain

EGF-like 12%3B calcium-binding

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

490_526

1170

2556.0

Domain

EGF-like 13%3B calcium-binding

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

528_564

1170

2556.0

Domain

EGF-like 14%3B calcium-binding

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

566_601

1170

2556.0

Domain

EGF-like 15%3B calcium-binding

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

59_99

1170

2556.0

Domain

EGF-like 2

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

603_639

1170

2556.0

Domain

EGF-like 16%3B calcium-binding

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

641_676

1170

2556.0

Domain

EGF-like 17%3B calcium-binding

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

678_714

1170

2556.0

Domain

EGF-like 18%3B calcium-binding

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

716_751

1170

2556.0

Domain

EGF-like 19%3B calcium-binding

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

753_789

1170

2556.0

Domain

EGF-like 20

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

791_827

1170

2556.0

Domain

EGF-like 21%3B calcium-binding

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

829_867

1170

2556.0

Domain

EGF-like 22

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

869_905

1170

2556.0

Domain

EGF-like 23%3B calcium-binding

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

907_943

1170

2556.0

Domain

EGF-like 24

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

945_981

1170

2556.0

Domain

EGF-like 25%3B calcium-binding

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

983_1019

1170

2556.0

Domain

EGF-like 26

Tgene

SDCCAG3

chr9:139402407

chr9:139300430

ENST00000298537

261_371

250

413.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SDCCAG3

chr9:139402407

chr9:139300430

ENST00000371725

261_371

200

363.0

Coiled coil

Ontology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

1575_1578

1170

2556.0

Compositional bias

Note=Poly-Val

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

1661_1664

1170

2556.0

Compositional bias

Note=Poly-Arg

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

1728_1731

1170

2556.0

Compositional bias

Note=Poly-Pro

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

1740_1743

1170

2556.0

Compositional bias

Note=Poly-Ala

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

1901_1904

1170

2556.0

Compositional bias

Note=Poly-Glu

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

2259_2262

1170

2556.0

Compositional bias

Note=Poly-Gly

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

2403_2406

1170

2556.0

Compositional bias

Note=Poly-Gln

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

2410_2417

1170

2556.0

Compositional bias

Note=Poly-Pro

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

2521_2524

1170

2556.0

Compositional bias

Note=Poly-Ser

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

1145_1181

1170

2556.0

Domain

EGF-like 30

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

1183_1219

1170

2556.0

Domain

EGF-like 31%3B calcium-binding

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

1221_1265

1170

2556.0

Domain

EGF-like 32%3B calcium-binding

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

1267_1305

1170

2556.0

Domain

EGF-like 33

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

1307_1346

1170

2556.0

Domain

EGF-like 34

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

1348_1384

1170

2556.0

Domain

EGF-like 35

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

1387_1426

1170

2556.0

Domain

EGF-like 36

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

1947_1955

1170

2556.0

Region

HIF1AN-binding

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

2014_2022

1170

2556.0

Region

HIF1AN-binding

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

1449_1489

1170

2556.0

Repeat

LNR 1

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

1490_1531

1170

2556.0

Repeat

LNR 2

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

1532_1571

1170

2556.0

Repeat

LNR 3

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

1927_1956

1170

2556.0

Repeat

ANK 1

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

1960_1990

1170

2556.0

Repeat

ANK 2

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

1994_2023

1170

2556.0

Repeat

ANK 3

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

2027_2056

1170

2556.0

Repeat

ANK 4

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

2060_2089

1170

2556.0

Repeat

ANK 5

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

2095_2122

1170

2556.0

Repeat

Note=ANK 6

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

1757_2555

1170

2556.0

Topological domain

Cytoplasmic

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

19_1735

1170

2556.0

Topological domain

Extracellular

Hgene

NOTCH1

chr9:139402407

chr9:139300430

ENST00000277541

1736_1756

1170

2556.0

Transmembrane

Helical

Tgene

SDCCAG3

chr9:139402407

chr9:139300430

ENST00000357365

261_371

273

436.0

Coiled coil

Ontology_term=ECO:0000255

Top

Fusion Gene Sequence for NOTCH1-SDCCAG3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>59715_59715_1_NOTCH1-SDCCAG3_NOTCH1_chr9_139402407_ENST00000277541_SDCCAG3_chr9_139300430_ENST00000298537_length(transcript)=4938nt_BP=3586nt
GCGCGTGTGCGTCCCAGCCCCGCCGGCCAGCGCAGGAGGCCGCCGCCCGGGCGCAGAGGGCAGCCGGTGGGGAGGCATGCCGCCGCTCCT
GGCGCCCCTGCTCTGCCTGGCGCTGCTGCCCGCGCTCGCCGCACGAGGCCCGCGATGCTCCCAGCCCGGTGAGACCTGCCTGAATGGCGG
GAAGTGTGAAGCGGCCAATGGCACGGAGGCCTGCGTCTGTGGCGGGGCCTTCGTGGGCCCGCGATGCCAGGACCCCAACCCGTGCCTCAG
CACCCCCTGCAAGAACGCCGGGACATGCCACGTGGTGGACCGCAGAGGCGTGGCAGACTATGCCTGCAGCTGTGCCCTGGGCTTCTCTGG
GCCCCTCTGCCTGACACCCCTGGACAATGCCTGCCTCACCAACCCCTGCCGCAACGGGGGCACCTGCGACCTGCTCACGCTGACGGAGTA
CAAGTGCCGCTGCCCGCCCGGCTGGTCAGGGAAATCGTGCCAGCAGGCTGACCCGTGCGCCTCCAACCCCTGCGCCAACGGTGGCCAGTG
CCTGCCCTTCGAGGCCTCCTACATCTGCCACTGCCCACCCAGCTTCCATGGCCCCACCTGCCGGCAGGATGTCAACGAGTGTGGCCAGAA
GCCCGGGCTTTGCCGCCACGGAGGCACCTGCCACAACGAGGTCGGCTCCTACCGCTGCGTCTGCCGCGCCACCCACACTGGCCCCAACTG
CGAGCGGCCCTACGTGCCCTGCAGCCCCTCGCCCTGCCAGAACGGGGGCACCTGCCGCCCCACGGGCGACGTCACCCACGAGTGTGCCTG
CCTGCCAGGCTTCACCGGCCAGAACTGTGAGGAAAATATCGACGATTGTCCAGGAAACAACTGCAAGAACGGGGGTGCCTGTGTGGACGG
CGTGAACACCTACAACTGCCGCTGCCCGCCAGAGTGGACAGGTCAGTACTGTACCGAGGATGTGGACGAGTGCCAGCTGATGCCAAATGC
CTGCCAGAACGGCGGGACCTGCCACAACACCCACGGTGGCTACAACTGCGTGTGTGTCAACGGCTGGACTGGTGAGGACTGCAGCGAGAA
CATTGATGACTGTGCCAGCGCCGCCTGCTTCCACGGCGCCACCTGCCATGACCGTGTGGCCTCCTTCTACTGCGAGTGTCCCCATGGCCG
CACAGGTCTGCTGTGCCACCTCAACGACGCATGCATCAGCAACCCCTGTAACGAGGGCTCCAACTGCGACACCAACCCTGTCAATGGCAA
GGCCATCTGCACCTGCCCCTCGGGGTACACGGGCCCGGCCTGCAGCCAGGACGTGGATGAGTGCTCGCTGGGTGCCAACCCCTGCGAGCA
TGCGGGCAAGTGCATCAACACGCTGGGCTCCTTCGAGTGCCAGTGTCTGCAGGGCTACACGGGCCCCCGATGCGAGATCGACGTCAACGA
GTGCGTCTCGAACCCGTGCCAGAACGACGCCACCTGCCTGGACCAGATTGGGGAGTTCCAGTGCATCTGCATGCCCGGCTACGAGGGTGT
GCACTGCGAGGTCAACACAGACGAGTGTGCCAGCAGCCCCTGCCTGCACAATGGCCGCTGCCTGGACAAGATCAATGAGTTCCAGTGCGA
GTGCCCCACGGGCTTCACTGGGCATCTGTGCCAGTACGATGTGGACGAGTGTGCCAGCACCCCCTGCAAGAATGGTGCCAAGTGCCTGGA
CGGACCCAACACTTACACCTGTGTGTGCACGGAAGGGTACACGGGGACGCACTGCGAGGTGGACATCGATGAGTGCGACCCCGACCCCTG
CCACTACGGCTCCTGCAAGGACGGCGTCGCCACCTTCACCTGCCTCTGCCGCCCAGGCTACACGGGCCACCACTGCGAGACCAACATCAA
CGAGTGCTCCAGCCAGCCCTGCCGCCACGGGGGCACCTGCCAGGACCGCGACAACGCCTACCTCTGCTTCTGCCTGAAGGGGACCACAGG
ACCCAACTGCGAGATCAACCTGGATGACTGTGCCAGCAGCCCCTGCGACTCGGGCACCTGTCTGGACAAGATCGATGGCTACGAGTGTGC
CTGTGAGCCGGGCTACACAGGGAGCATGTGTAACATCAACATCGATGAGTGTGCGGGCAACCCCTGCCACAACGGGGGCACCTGCGAGGA
CGGCATCAATGGCTTCACCTGCCGCTGCCCCGAGGGCTACCACGACCCCACCTGCCTGTCTGAGGTCAATGAGTGCAACAGCAACCCCTG
CGTCCACGGGGCCTGCCGGGACAGCCTCAACGGGTACAAGTGCGACTGTGACCCTGGGTGGAGTGGGACCAACTGTGACATCAACAACAA
TGAGTGTGAATCCAACCCTTGTGTCAACGGCGGCACCTGCAAAGACATGACCAGTGGCTACGTGTGCACCTGCCGGGAGGGCTTCAGCGG
TCCCAACTGCCAGACCAACATCAACGAGTGTGCGTCCAACCCATGTCTGAACCAGGGCACGTGTATTGACGACGTTGCCGGGTACAAGTG
CAACTGCCTGCTGCCCTACACAGGTGCCACGTGTGAGGTGGTGCTGGCCCCGTGTGCCCCCAGCCCCTGCAGAAACGGCGGGGAGTGCAG
GCAATCCGAGGACTATGAGAGCTTCTCCTGTGTCTGCCCCACGGGCTGGCAAGGGCAGACCTGTGAGGTCGACATCAACGAGTGCGTTCT
GAGCCCGTGCCGGCACGGCGCATCCTGCCAGAACACCCACGGCGGCTACCGCTGCCACTGCCAGGCCGGCTACAGTGGGCGCAACTGCGA
GACCGACATCGACGACTGCCGGCCCAACCCGTGTCACAACGGGGGCTCCTGCACAGACGGCATCAACACGGCCTTCTGCGACTGCCTGCC
CGGCTTCCGGGGCACTTTCTGTGAGGAGGACATCAACGAGTGTGCCAGTGACCCCTGCCGCAACGGGGCCAACTGCACGGACTGCGTGGA
CAGCTACACGTGCACCTGCCCCGCAGGCTTCAGCGGGATCCACTGTGAGAACAACACGCCTGACTGCACAGAGAGCTCCTGCTTCAACGG
TGGCACCTGCGTGGACGGCATCAACTCGTTCACCTGCCTGTGTCCACCCGGCTTCACGGGCAGCTACTGCCAGCACGATGTCAATGAGTG
CGACTCACAGCCCTGCCTGCATGGCGGCACCTGTCAGGACGGCTGCGGCTCCTACAGGTGCACCTGCCCCCAGGGCTACACTGGCCCCAA
CTGCCAGAACCTTGTGCACTGGTGTGACTCCTCGCCCTGCAAGAACGGCGGCAAATGCTGGCAGACCCACACCCAGTACCGCTGCGAGTG
CCCCAGCGGCTGGACCGGCCTTTACTGCGACGTGCCCAGCGTGTCCTGTGAGGTGGCTGCGCAGCGACAAGGTGTTGACGTTGCCCGCCT
GTGCCAGCATGGAGGGCTCTGTGTGGACGCGGGCAACACGCACCACTGCCGCTGCCAGGCGGGCTACACAGGCAGCTACTGTGAGGACCT
GGTGGACGAGTGCTCACCCAGCCCCTGCCAGAACGGGGCCACCTGCACGGACTACCTGGGCGGCTACTCCTGCAAGCTGAAAGATGAAAA
TTCTAAGCTGAGAAGAAAGCTGAATGAGGTTCAGAGCTTCTCTGAAGCTCAAACAGAAATGGTGAGGACGCTTGAGCGGAAGTTAGAAGC
AAAAATGATCAAGGAGGAAAGCGACTACCACGACCTGGAGTCGGTGGTTCAGCAGGTGGAGCAGAACCTGGAGCTGATGACCAAACGGGC
TGTAAAGGCAGAAAACCACGTCGTGAAACTAAAACAGGAAATCAGTTTGCTCCAGGCGCAGGTCTCCAACTTCCAGCGAGAGAATGAAGC
CCTGCGGTGCGGCCAGGGTGCCAGCCTGACCGTGGTGAAGCAGAACGCCGACGTGGCCCTGCAGAACCTCCGGGTGGTCATGAACAGTGC
ACAGGCTTCCATCAAGCAACTGGTTTCCGGAGCTGAGACACTGAATCTTGTTGCCGAAATCCTTAAATCTATAGACAGAATTTCTGAAGT
TAAAGACGAGGAGGAAGACTCTTGAGGACCCCTGGGTGTTCTCAGCATGAAGCTCCGTGTATACCCTGAGGTCACCACCGCTCGATCTAA
ATGTGCAGTTGTGTCCTTAAATATGCAGTCTTCACCCAGAGTAAAGTGTTGATCGCAAGAGTCCAGTGTCGTGCCCTCAGCCAGTTCTTG
GCCACCACAATGGGAGCAGCCCTGGCCGAGTTGTCTCTGTGGTTTCTATGCAGCCCTTCTTGGCGAAATTCCTGCGATCTTATAGATTCT
AATGAGCTCTTGGAAGACATTGTCATAAAAGCCAGTGATTTTAAGAAAAAGAGTGGTTCTGGAATCAATGTTTTCCAGTCCCATCCCAGA
ACATCAGTTGTAAGATAAGTACAATTGGTTGTCCTTGATTTCATAAGTAGAACAAACACTAAATGTGCCTCTGAGATGGCCACCCCGGGC
AGGGACCTGTGCCTTCCGCCGATGCTCAGGGCTCCCTCTGGCTCCCGGGTCACTCTTGTGGCCCCAGTGGGTGGTCCCTGCAGTCATGGC
CTGAGTGCGCAGGGGCCACCGCGTGGCTGCTGCTGTCCTCCTCCGGGACCCACGGGGACCAAGGTCACACGTTCCGTGCTGTGAAGCTGT
CCAGATGTGCCTCTTTGGCTGGGGGTTCTGGTGGACGTTTCAAGTGGCATTTTGTACAATGCAGGTTAGAATTCAGGAATTTCAAGTATG
TGCCCGGGTCTGTCAGGTCCCAGTTGCCTTTCTGACGGCCCCCCTCAGAGGGACGGCGATGAGCACTAAATGCTTTTTTGACTATTTTCC

>59715_59715_1_NOTCH1-SDCCAG3_NOTCH1_chr9_139402407_ENST00000277541_SDCCAG3_chr9_139300430_ENST00000298537_length(amino acids)=1332AA_BP=0
MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCA
LGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVN
ECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGG
ACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCE
CPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCE
IDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNG
AKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCL
KGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNEC
NSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDV
AGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYS
GRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTES
SCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQ
YRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCK
LKDENSKLRRKLNEVQSFSEAQTEMVRTLERKLEAKMIKEESDYHDLESVVQQVEQNLELMTKRAVKAENHVVKLKQEISLLQAQVSNFQ

--------------------------------------------------------------
>59715_59715_2_NOTCH1-SDCCAG3_NOTCH1_chr9_139402407_ENST00000277541_SDCCAG3_chr9_139300430_ENST00000357365_length(transcript)=4938nt_BP=3586nt
GCGCGTGTGCGTCCCAGCCCCGCCGGCCAGCGCAGGAGGCCGCCGCCCGGGCGCAGAGGGCAGCCGGTGGGGAGGCATGCCGCCGCTCCT
GGCGCCCCTGCTCTGCCTGGCGCTGCTGCCCGCGCTCGCCGCACGAGGCCCGCGATGCTCCCAGCCCGGTGAGACCTGCCTGAATGGCGG
GAAGTGTGAAGCGGCCAATGGCACGGAGGCCTGCGTCTGTGGCGGGGCCTTCGTGGGCCCGCGATGCCAGGACCCCAACCCGTGCCTCAG
CACCCCCTGCAAGAACGCCGGGACATGCCACGTGGTGGACCGCAGAGGCGTGGCAGACTATGCCTGCAGCTGTGCCCTGGGCTTCTCTGG
GCCCCTCTGCCTGACACCCCTGGACAATGCCTGCCTCACCAACCCCTGCCGCAACGGGGGCACCTGCGACCTGCTCACGCTGACGGAGTA
CAAGTGCCGCTGCCCGCCCGGCTGGTCAGGGAAATCGTGCCAGCAGGCTGACCCGTGCGCCTCCAACCCCTGCGCCAACGGTGGCCAGTG
CCTGCCCTTCGAGGCCTCCTACATCTGCCACTGCCCACCCAGCTTCCATGGCCCCACCTGCCGGCAGGATGTCAACGAGTGTGGCCAGAA
GCCCGGGCTTTGCCGCCACGGAGGCACCTGCCACAACGAGGTCGGCTCCTACCGCTGCGTCTGCCGCGCCACCCACACTGGCCCCAACTG
CGAGCGGCCCTACGTGCCCTGCAGCCCCTCGCCCTGCCAGAACGGGGGCACCTGCCGCCCCACGGGCGACGTCACCCACGAGTGTGCCTG
CCTGCCAGGCTTCACCGGCCAGAACTGTGAGGAAAATATCGACGATTGTCCAGGAAACAACTGCAAGAACGGGGGTGCCTGTGTGGACGG
CGTGAACACCTACAACTGCCGCTGCCCGCCAGAGTGGACAGGTCAGTACTGTACCGAGGATGTGGACGAGTGCCAGCTGATGCCAAATGC
CTGCCAGAACGGCGGGACCTGCCACAACACCCACGGTGGCTACAACTGCGTGTGTGTCAACGGCTGGACTGGTGAGGACTGCAGCGAGAA
CATTGATGACTGTGCCAGCGCCGCCTGCTTCCACGGCGCCACCTGCCATGACCGTGTGGCCTCCTTCTACTGCGAGTGTCCCCATGGCCG
CACAGGTCTGCTGTGCCACCTCAACGACGCATGCATCAGCAACCCCTGTAACGAGGGCTCCAACTGCGACACCAACCCTGTCAATGGCAA
GGCCATCTGCACCTGCCCCTCGGGGTACACGGGCCCGGCCTGCAGCCAGGACGTGGATGAGTGCTCGCTGGGTGCCAACCCCTGCGAGCA
TGCGGGCAAGTGCATCAACACGCTGGGCTCCTTCGAGTGCCAGTGTCTGCAGGGCTACACGGGCCCCCGATGCGAGATCGACGTCAACGA
GTGCGTCTCGAACCCGTGCCAGAACGACGCCACCTGCCTGGACCAGATTGGGGAGTTCCAGTGCATCTGCATGCCCGGCTACGAGGGTGT
GCACTGCGAGGTCAACACAGACGAGTGTGCCAGCAGCCCCTGCCTGCACAATGGCCGCTGCCTGGACAAGATCAATGAGTTCCAGTGCGA
GTGCCCCACGGGCTTCACTGGGCATCTGTGCCAGTACGATGTGGACGAGTGTGCCAGCACCCCCTGCAAGAATGGTGCCAAGTGCCTGGA
CGGACCCAACACTTACACCTGTGTGTGCACGGAAGGGTACACGGGGACGCACTGCGAGGTGGACATCGATGAGTGCGACCCCGACCCCTG
CCACTACGGCTCCTGCAAGGACGGCGTCGCCACCTTCACCTGCCTCTGCCGCCCAGGCTACACGGGCCACCACTGCGAGACCAACATCAA
CGAGTGCTCCAGCCAGCCCTGCCGCCACGGGGGCACCTGCCAGGACCGCGACAACGCCTACCTCTGCTTCTGCCTGAAGGGGACCACAGG
ACCCAACTGCGAGATCAACCTGGATGACTGTGCCAGCAGCCCCTGCGACTCGGGCACCTGTCTGGACAAGATCGATGGCTACGAGTGTGC
CTGTGAGCCGGGCTACACAGGGAGCATGTGTAACATCAACATCGATGAGTGTGCGGGCAACCCCTGCCACAACGGGGGCACCTGCGAGGA
CGGCATCAATGGCTTCACCTGCCGCTGCCCCGAGGGCTACCACGACCCCACCTGCCTGTCTGAGGTCAATGAGTGCAACAGCAACCCCTG
CGTCCACGGGGCCTGCCGGGACAGCCTCAACGGGTACAAGTGCGACTGTGACCCTGGGTGGAGTGGGACCAACTGTGACATCAACAACAA
TGAGTGTGAATCCAACCCTTGTGTCAACGGCGGCACCTGCAAAGACATGACCAGTGGCTACGTGTGCACCTGCCGGGAGGGCTTCAGCGG
TCCCAACTGCCAGACCAACATCAACGAGTGTGCGTCCAACCCATGTCTGAACCAGGGCACGTGTATTGACGACGTTGCCGGGTACAAGTG
CAACTGCCTGCTGCCCTACACAGGTGCCACGTGTGAGGTGGTGCTGGCCCCGTGTGCCCCCAGCCCCTGCAGAAACGGCGGGGAGTGCAG
GCAATCCGAGGACTATGAGAGCTTCTCCTGTGTCTGCCCCACGGGCTGGCAAGGGCAGACCTGTGAGGTCGACATCAACGAGTGCGTTCT
GAGCCCGTGCCGGCACGGCGCATCCTGCCAGAACACCCACGGCGGCTACCGCTGCCACTGCCAGGCCGGCTACAGTGGGCGCAACTGCGA
GACCGACATCGACGACTGCCGGCCCAACCCGTGTCACAACGGGGGCTCCTGCACAGACGGCATCAACACGGCCTTCTGCGACTGCCTGCC
CGGCTTCCGGGGCACTTTCTGTGAGGAGGACATCAACGAGTGTGCCAGTGACCCCTGCCGCAACGGGGCCAACTGCACGGACTGCGTGGA
CAGCTACACGTGCACCTGCCCCGCAGGCTTCAGCGGGATCCACTGTGAGAACAACACGCCTGACTGCACAGAGAGCTCCTGCTTCAACGG
TGGCACCTGCGTGGACGGCATCAACTCGTTCACCTGCCTGTGTCCACCCGGCTTCACGGGCAGCTACTGCCAGCACGATGTCAATGAGTG
CGACTCACAGCCCTGCCTGCATGGCGGCACCTGTCAGGACGGCTGCGGCTCCTACAGGTGCACCTGCCCCCAGGGCTACACTGGCCCCAA
CTGCCAGAACCTTGTGCACTGGTGTGACTCCTCGCCCTGCAAGAACGGCGGCAAATGCTGGCAGACCCACACCCAGTACCGCTGCGAGTG
CCCCAGCGGCTGGACCGGCCTTTACTGCGACGTGCCCAGCGTGTCCTGTGAGGTGGCTGCGCAGCGACAAGGTGTTGACGTTGCCCGCCT
GTGCCAGCATGGAGGGCTCTGTGTGGACGCGGGCAACACGCACCACTGCCGCTGCCAGGCGGGCTACACAGGCAGCTACTGTGAGGACCT
GGTGGACGAGTGCTCACCCAGCCCCTGCCAGAACGGGGCCACCTGCACGGACTACCTGGGCGGCTACTCCTGCAAGCTGAAAGATGAAAA
TTCTAAGCTGAGAAGAAAGCTGAATGAGGTTCAGAGCTTCTCTGAAGCTCAAACAGAAATGGTGAGGACGCTTGAGCGGAAGTTAGAAGC
AAAAATGATCAAGGAGGAAAGCGACTACCACGACCTGGAGTCGGTGGTTCAGCAGGTGGAGCAGAACCTGGAGCTGATGACCAAACGGGC
TGTAAAGGCAGAAAACCACGTCGTGAAACTAAAACAGGAAATCAGTTTGCTCCAGGCGCAGGTCTCCAACTTCCAGCGAGAGAATGAAGC
CCTGCGGTGCGGCCAGGGTGCCAGCCTGACCGTGGTGAAGCAGAACGCCGACGTGGCCCTGCAGAACCTCCGGGTGGTCATGAACAGTGC
ACAGGCTTCCATCAAGCAACTGGTTTCCGGAGCTGAGACACTGAATCTTGTTGCCGAAATCCTTAAATCTATAGACAGAATTTCTGAAGT
TAAAGACGAGGAGGAAGACTCTTGAGGACCCCTGGGTGTTCTCAGCATGAAGCTCCGTGTATACCCTGAGGTCACCACCGCTCGATCTAA
ATGTGCAGTTGTGTCCTTAAATATGCAGTCTTCACCCAGAGTAAAGTGTTGATCGCAAGAGTCCAGTGTCGTGCCCTCAGCCAGTTCTTG
GCCACCACAATGGGAGCAGCCCTGGCCGAGTTGTCTCTGTGGTTTCTATGCAGCCCTTCTTGGCGAAATTCCTGCGATCTTATAGATTCT
AATGAGCTCTTGGAAGACATTGTCATAAAAGCCAGTGATTTTAAGAAAAAGAGTGGTTCTGGAATCAATGTTTTCCAGTCCCATCCCAGA
ACATCAGTTGTAAGATAAGTACAATTGGTTGTCCTTGATTTCATAAGTAGAACAAACACTAAATGTGCCTCTGAGATGGCCACCCCGGGC
AGGGACCTGTGCCTTCCGCCGATGCTCAGGGCTCCCTCTGGCTCCCGGGTCACTCTTGTGGCCCCAGTGGGTGGTCCCTGCAGTCATGGC
CTGAGTGCGCAGGGGCCACCGCGTGGCTGCTGCTGTCCTCCTCCGGGACCCACGGGGACCAAGGTCACACGTTCCGTGCTGTGAAGCTGT
CCAGATGTGCCTCTTTGGCTGGGGGTTCTGGTGGACGTTTCAAGTGGCATTTTGTACAATGCAGGTTAGAATTCAGGAATTTCAAGTATG
TGCCCGGGTCTGTCAGGTCCCAGTTGCCTTTCTGACGGCCCCCCTCAGAGGGACGGCGATGAGCACTAAATGCTTTTTTGACTATTTTCC

>59715_59715_2_NOTCH1-SDCCAG3_NOTCH1_chr9_139402407_ENST00000277541_SDCCAG3_chr9_139300430_ENST00000357365_length(amino acids)=1332AA_BP=0
MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCA
LGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVN
ECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGG
ACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCE
CPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCE
IDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNG
AKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCL
KGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNEC
NSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDV
AGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYS
GRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTES
SCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQ
YRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCK
LKDENSKLRRKLNEVQSFSEAQTEMVRTLERKLEAKMIKEESDYHDLESVVQQVEQNLELMTKRAVKAENHVVKLKQEISLLQAQVSNFQ

--------------------------------------------------------------
>59715_59715_3_NOTCH1-SDCCAG3_NOTCH1_chr9_139402407_ENST00000277541_SDCCAG3_chr9_139300430_ENST00000371725_length(transcript)=4912nt_BP=3586nt
GCGCGTGTGCGTCCCAGCCCCGCCGGCCAGCGCAGGAGGCCGCCGCCCGGGCGCAGAGGGCAGCCGGTGGGGAGGCATGCCGCCGCTCCT
GGCGCCCCTGCTCTGCCTGGCGCTGCTGCCCGCGCTCGCCGCACGAGGCCCGCGATGCTCCCAGCCCGGTGAGACCTGCCTGAATGGCGG
GAAGTGTGAAGCGGCCAATGGCACGGAGGCCTGCGTCTGTGGCGGGGCCTTCGTGGGCCCGCGATGCCAGGACCCCAACCCGTGCCTCAG
CACCCCCTGCAAGAACGCCGGGACATGCCACGTGGTGGACCGCAGAGGCGTGGCAGACTATGCCTGCAGCTGTGCCCTGGGCTTCTCTGG
GCCCCTCTGCCTGACACCCCTGGACAATGCCTGCCTCACCAACCCCTGCCGCAACGGGGGCACCTGCGACCTGCTCACGCTGACGGAGTA
CAAGTGCCGCTGCCCGCCCGGCTGGTCAGGGAAATCGTGCCAGCAGGCTGACCCGTGCGCCTCCAACCCCTGCGCCAACGGTGGCCAGTG
CCTGCCCTTCGAGGCCTCCTACATCTGCCACTGCCCACCCAGCTTCCATGGCCCCACCTGCCGGCAGGATGTCAACGAGTGTGGCCAGAA
GCCCGGGCTTTGCCGCCACGGAGGCACCTGCCACAACGAGGTCGGCTCCTACCGCTGCGTCTGCCGCGCCACCCACACTGGCCCCAACTG
CGAGCGGCCCTACGTGCCCTGCAGCCCCTCGCCCTGCCAGAACGGGGGCACCTGCCGCCCCACGGGCGACGTCACCCACGAGTGTGCCTG
CCTGCCAGGCTTCACCGGCCAGAACTGTGAGGAAAATATCGACGATTGTCCAGGAAACAACTGCAAGAACGGGGGTGCCTGTGTGGACGG
CGTGAACACCTACAACTGCCGCTGCCCGCCAGAGTGGACAGGTCAGTACTGTACCGAGGATGTGGACGAGTGCCAGCTGATGCCAAATGC
CTGCCAGAACGGCGGGACCTGCCACAACACCCACGGTGGCTACAACTGCGTGTGTGTCAACGGCTGGACTGGTGAGGACTGCAGCGAGAA
CATTGATGACTGTGCCAGCGCCGCCTGCTTCCACGGCGCCACCTGCCATGACCGTGTGGCCTCCTTCTACTGCGAGTGTCCCCATGGCCG
CACAGGTCTGCTGTGCCACCTCAACGACGCATGCATCAGCAACCCCTGTAACGAGGGCTCCAACTGCGACACCAACCCTGTCAATGGCAA
GGCCATCTGCACCTGCCCCTCGGGGTACACGGGCCCGGCCTGCAGCCAGGACGTGGATGAGTGCTCGCTGGGTGCCAACCCCTGCGAGCA
TGCGGGCAAGTGCATCAACACGCTGGGCTCCTTCGAGTGCCAGTGTCTGCAGGGCTACACGGGCCCCCGATGCGAGATCGACGTCAACGA
GTGCGTCTCGAACCCGTGCCAGAACGACGCCACCTGCCTGGACCAGATTGGGGAGTTCCAGTGCATCTGCATGCCCGGCTACGAGGGTGT
GCACTGCGAGGTCAACACAGACGAGTGTGCCAGCAGCCCCTGCCTGCACAATGGCCGCTGCCTGGACAAGATCAATGAGTTCCAGTGCGA
GTGCCCCACGGGCTTCACTGGGCATCTGTGCCAGTACGATGTGGACGAGTGTGCCAGCACCCCCTGCAAGAATGGTGCCAAGTGCCTGGA
CGGACCCAACACTTACACCTGTGTGTGCACGGAAGGGTACACGGGGACGCACTGCGAGGTGGACATCGATGAGTGCGACCCCGACCCCTG
CCACTACGGCTCCTGCAAGGACGGCGTCGCCACCTTCACCTGCCTCTGCCGCCCAGGCTACACGGGCCACCACTGCGAGACCAACATCAA
CGAGTGCTCCAGCCAGCCCTGCCGCCACGGGGGCACCTGCCAGGACCGCGACAACGCCTACCTCTGCTTCTGCCTGAAGGGGACCACAGG
ACCCAACTGCGAGATCAACCTGGATGACTGTGCCAGCAGCCCCTGCGACTCGGGCACCTGTCTGGACAAGATCGATGGCTACGAGTGTGC
CTGTGAGCCGGGCTACACAGGGAGCATGTGTAACATCAACATCGATGAGTGTGCGGGCAACCCCTGCCACAACGGGGGCACCTGCGAGGA
CGGCATCAATGGCTTCACCTGCCGCTGCCCCGAGGGCTACCACGACCCCACCTGCCTGTCTGAGGTCAATGAGTGCAACAGCAACCCCTG
CGTCCACGGGGCCTGCCGGGACAGCCTCAACGGGTACAAGTGCGACTGTGACCCTGGGTGGAGTGGGACCAACTGTGACATCAACAACAA
TGAGTGTGAATCCAACCCTTGTGTCAACGGCGGCACCTGCAAAGACATGACCAGTGGCTACGTGTGCACCTGCCGGGAGGGCTTCAGCGG
TCCCAACTGCCAGACCAACATCAACGAGTGTGCGTCCAACCCATGTCTGAACCAGGGCACGTGTATTGACGACGTTGCCGGGTACAAGTG
CAACTGCCTGCTGCCCTACACAGGTGCCACGTGTGAGGTGGTGCTGGCCCCGTGTGCCCCCAGCCCCTGCAGAAACGGCGGGGAGTGCAG
GCAATCCGAGGACTATGAGAGCTTCTCCTGTGTCTGCCCCACGGGCTGGCAAGGGCAGACCTGTGAGGTCGACATCAACGAGTGCGTTCT
GAGCCCGTGCCGGCACGGCGCATCCTGCCAGAACACCCACGGCGGCTACCGCTGCCACTGCCAGGCCGGCTACAGTGGGCGCAACTGCGA
GACCGACATCGACGACTGCCGGCCCAACCCGTGTCACAACGGGGGCTCCTGCACAGACGGCATCAACACGGCCTTCTGCGACTGCCTGCC
CGGCTTCCGGGGCACTTTCTGTGAGGAGGACATCAACGAGTGTGCCAGTGACCCCTGCCGCAACGGGGCCAACTGCACGGACTGCGTGGA
CAGCTACACGTGCACCTGCCCCGCAGGCTTCAGCGGGATCCACTGTGAGAACAACACGCCTGACTGCACAGAGAGCTCCTGCTTCAACGG
TGGCACCTGCGTGGACGGCATCAACTCGTTCACCTGCCTGTGTCCACCCGGCTTCACGGGCAGCTACTGCCAGCACGATGTCAATGAGTG
CGACTCACAGCCCTGCCTGCATGGCGGCACCTGTCAGGACGGCTGCGGCTCCTACAGGTGCACCTGCCCCCAGGGCTACACTGGCCCCAA
CTGCCAGAACCTTGTGCACTGGTGTGACTCCTCGCCCTGCAAGAACGGCGGCAAATGCTGGCAGACCCACACCCAGTACCGCTGCGAGTG
CCCCAGCGGCTGGACCGGCCTTTACTGCGACGTGCCCAGCGTGTCCTGTGAGGTGGCTGCGCAGCGACAAGGTGTTGACGTTGCCCGCCT
GTGCCAGCATGGAGGGCTCTGTGTGGACGCGGGCAACACGCACCACTGCCGCTGCCAGGCGGGCTACACAGGCAGCTACTGTGAGGACCT
GGTGGACGAGTGCTCACCCAGCCCCTGCCAGAACGGGGCCACCTGCACGGACTACCTGGGCGGCTACTCCTGCAAGCTGAAAGATGAAAA
TTCTAAGCTGAGAAGAAAGCTGAATGAGGTTCAGAGCTTCTCTGAAGCTCAAACAGAAATGGTGAGGACGCTTGAGCGGAAGTTAGAAGC
AAAAATGATCAAGGAGGAAAGCGACTACCACGACCTGGAGTCGGTGGTTCAGCAGGTGGAGCAGAACCTGGAGCTGATGACCAAACGGGC
TGTAAAGGCAGAAAACCACGTCGTGAAACTAAAACAGGAAATCAGTTTGCTCCAGGCGCAGGTCTCCAACTTCCAGCGAGAGAATGAAGC
CCTGCGGTGCGGCCAGGGTGCCAGCCTGACCGTGGTGAAGCAGAACGCCGACGTGGCCCTGCAGAACCTCCGGGTGGTCATGAACAGTGC
ACAGGCTTCCATCAAGCAACTGGTTTCCGGAGCTGAGACACTGAATCTTGTTGCCGAAATCCTTAAATCTATAGACAGAATTTCTGAAGT
TAAAGACGAGGAGGAAGACTCTTGAGGACCCCTGGGTGTTCTCAGCATGAAGCTCCGTGTATACCCTGAGGTCACCACCGCTCGATCTAA
ATGTGCAGTTGTGTCCTTAAATATGCAGTCTTCACCCAGAGTAAAGTGTTGATCGCAAGAGTCCAGTGTCGTGCCCTCAGCCAGTTCTTG
GCCACCACAATGGGAGCAGCCCTGGCCGAGTTGTCTCTGTGGTTTCTATGCAGCCCTTCTTGGCGAAATTCCTGCGATCTTATAGATTCT
AATGAGCTCTTGGAAGACATTGTCATAAAAGCCAGTGATTTTAAGAAAAAGAGTGGTTCTGGAATCAATGTTTTCCAGTCCCATCCCAGA
ACATCAGTTGTAAGATAAGTACAATTGGTTGTCCTTGATTTCATAAGTAGAACAAACACTAAATGTGCCTCTGAGATGGCCACCCCGGGC
AGGGACCTGTGCCTTCCGCCGATGCTCAGGGCTCCCTCTGGCTCCCGGGTCACTCTTGTGGCCCCAGTGGGTGGTCCCTGCAGTCATGGC
CTGAGTGCGCAGGGGCCACCGCGTGGCTGCTGCTGTCCTCCTCCGGGACCCACGGGGACCAAGGTCACACGTTCCGTGCTGTGAAGCTGT
CCAGATGTGCCTCTTTGGCTGGGGGTTCTGGTGGACGTTTCAAGTGGCATTTTGTACAATGCAGGTTAGAATTCAGGAATTTCAAGTATG
TGCCCGGGTCTGTCAGGTCCCAGTTGCCTTTCTGACGGCCCCCCTCAGAGGGACGGCGATGAGCACTAAATGCTTTTTTGACTATTTTCC

>59715_59715_3_NOTCH1-SDCCAG3_NOTCH1_chr9_139402407_ENST00000277541_SDCCAG3_chr9_139300430_ENST00000371725_length(amino acids)=1332AA_BP=0
MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCA
LGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVN
ECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGG
ACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCE
CPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCE
IDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNG
AKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCL
KGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNEC
NSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDV
AGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYS
GRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTES
SCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQ
YRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCK
LKDENSKLRRKLNEVQSFSEAQTEMVRTLERKLEAKMIKEESDYHDLESVVQQVEQNLELMTKRAVKAENHVVKLKQEISLLQAQVSNFQ

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NOTCH1-SDCCAG3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	NOTCH1	chr9:139402407	chr9:139300430	ENST00000277541	-	21	34	420_421	1170.0	2556.0	DLL4
Hgene	NOTCH1	chr9:139402407	chr9:139300430	ENST00000277541	-	21	34	448_452	1170.0	2556.0	DLL4

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	NOTCH1	chr9:139402407	chr9:139300430	ENST00000277541	-	21	34	1728_1760	1170.0	2556.0	PSEN1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for NOTCH1-SDCCAG3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for NOTCH1-SDCCAG3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source