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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NOTCH2-PDE4DIP (FusionGDB2 ID:59764)

Fusion Gene Summary for NOTCH2-PDE4DIP

check button Fusion gene summary
Fusion gene informationFusion gene name: NOTCH2-PDE4DIP
Fusion gene ID: 59764
HgeneTgene
Gene symbol

NOTCH2

PDE4DIP

Gene ID

4853

9659

Gene namenotch receptor 2phosphodiesterase 4D interacting protein
SynonymsAGS2|HJCYS|hN2CMYA2|MMGL
Cytomap

1p12

1q21.2

Type of geneprotein-codingprotein-coding
Descriptionneurogenic locus notch homolog protein 2Notch homolog 2notch 2myomegalincardiomyopathy-associated protein 2myomegalin/phosphodiesterase 4D interacting protein variant 8
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000256646, ENST00000602566, 
ENST00000493703, 		ENST00000313431, 
ENST00000369345, ENST00000369347, 
ENST00000369348, ENST00000369349, 
ENST00000369351, ENST00000369354, 
ENST00000369356, ENST00000369359, 
ENST00000478649, ENST00000479408, 
ENST00000493130, ENST00000524974, 
ENST00000529945, ENST00000530740, 
ENST00000313382, 
Fusion gene scores* DoF score26 X 22 X 14=800812 X 9 X 8=864
# samples 3513
** MAII scorelog2(35/8008*10)=-4.51601514700366
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/864*10)=-2.73251968913501
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NOTCH2 [Title/Abstract] AND PDE4DIP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNOTCH2(120466260)-PDE4DIP(144994701), # samples:1
NOTCH2(120572529)-PDE4DIP(145021167), # samples:1
Anticipated loss of major functional domain due to fusion event.NOTCH2-PDE4DIP seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NOTCH2-PDE4DIP seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
NOTCH2-PDE4DIP seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
NOTCH2-PDE4DIP seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
NOTCH2-PDE4DIP seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNOTCH2

GO:0007050

cell cycle arrest

11306509

HgeneNOTCH2

GO:0007219

Notch signaling pathway

11306509|25985737

HgeneNOTCH2

GO:0010629

negative regulation of gene expression

11306509

HgeneNOTCH2

GO:0010838

positive regulation of keratinocyte proliferation

18469519

HgeneNOTCH2

GO:0045967

negative regulation of growth rate

11306509

HgeneNOTCH2

GO:0046579

positive regulation of Ras protein signal transduction

11306509

HgeneNOTCH2

GO:0070374

positive regulation of ERK1 and ERK2 cascade

11306509

HgeneNOTCH2

GO:2000249

regulation of actin cytoskeleton reorganization

18469519

TgenePDE4DIP

GO:1903358

regulation of Golgi organization

27666745


check buttonFusion gene breakpoints across NOTCH2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PDE4DIP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-NJ-A4YF-01ANOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
ChimerDB4PRADTCGA-EJ-5527NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-


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Fusion Gene ORF analysis for NOTCH2-PDE4DIP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000256646ENST00000313431NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
5CDS-intronENST00000256646ENST00000313431NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000256646ENST00000369345NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
5CDS-intronENST00000256646ENST00000369345NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000256646ENST00000369347NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000256646ENST00000369348NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000256646ENST00000369349NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000256646ENST00000369351NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000256646ENST00000369354NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000256646ENST00000369356NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000256646ENST00000369359NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000256646ENST00000478649NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
5CDS-intronENST00000256646ENST00000478649NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000256646ENST00000479408NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
5CDS-intronENST00000256646ENST00000479408NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000256646ENST00000493130NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
5CDS-intronENST00000256646ENST00000493130NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000256646ENST00000524974NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
5CDS-intronENST00000256646ENST00000524974NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000256646ENST00000529945NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
5CDS-intronENST00000256646ENST00000529945NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000256646ENST00000530740NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000602566ENST00000313431NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000602566ENST00000369345NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000602566ENST00000369347NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000602566ENST00000369348NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000602566ENST00000369349NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000602566ENST00000369351NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000602566ENST00000369354NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000602566ENST00000369356NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000602566ENST00000369359NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000602566ENST00000478649NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000602566ENST00000479408NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000602566ENST00000493130NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000602566ENST00000524974NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000602566ENST00000529945NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5CDS-intronENST00000602566ENST00000530740NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
5UTR-3CDSENST00000493703ENST00000313382NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
5UTR-3CDSENST00000493703ENST00000369347NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
5UTR-3CDSENST00000493703ENST00000369348NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
5UTR-3CDSENST00000493703ENST00000369349NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
5UTR-3CDSENST00000493703ENST00000369351NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
5UTR-3CDSENST00000493703ENST00000369354NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
5UTR-3CDSENST00000493703ENST00000369356NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
5UTR-3CDSENST00000493703ENST00000369359NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
5UTR-3CDSENST00000493703ENST00000530740NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
5UTR-intronENST00000493703ENST00000313431NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
5UTR-intronENST00000493703ENST00000369345NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
5UTR-intronENST00000493703ENST00000478649NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
5UTR-intronENST00000493703ENST00000479408NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
5UTR-intronENST00000493703ENST00000493130NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
5UTR-intronENST00000493703ENST00000524974NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
5UTR-intronENST00000493703ENST00000529945NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
Frame-shiftENST00000256646ENST00000313382NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
Frame-shiftENST00000256646ENST00000369347NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
Frame-shiftENST00000256646ENST00000369348NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
Frame-shiftENST00000256646ENST00000369349NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
Frame-shiftENST00000256646ENST00000369351NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
Frame-shiftENST00000256646ENST00000369354NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
Frame-shiftENST00000256646ENST00000369356NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
Frame-shiftENST00000256646ENST00000369359NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
Frame-shiftENST00000256646ENST00000530740NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
Frame-shiftENST00000602566ENST00000313382NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
In-frameENST00000256646ENST00000313382NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
intron-3CDSENST00000493703ENST00000313382NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
intron-3CDSENST00000602566ENST00000313382NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
intron-3CDSENST00000602566ENST00000369347NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
intron-3CDSENST00000602566ENST00000369348NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
intron-3CDSENST00000602566ENST00000369349NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
intron-3CDSENST00000602566ENST00000369351NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
intron-3CDSENST00000602566ENST00000369354NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
intron-3CDSENST00000602566ENST00000369356NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
intron-3CDSENST00000602566ENST00000369359NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
intron-3CDSENST00000602566ENST00000530740NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
intron-intronENST00000493703ENST00000313431NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
intron-intronENST00000493703ENST00000369345NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
intron-intronENST00000493703ENST00000369347NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
intron-intronENST00000493703ENST00000369348NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
intron-intronENST00000493703ENST00000369349NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
intron-intronENST00000493703ENST00000369351NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
intron-intronENST00000493703ENST00000369354NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
intron-intronENST00000493703ENST00000369356NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
intron-intronENST00000493703ENST00000369359NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
intron-intronENST00000493703ENST00000478649NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
intron-intronENST00000493703ENST00000479408NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
intron-intronENST00000493703ENST00000493130NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
intron-intronENST00000493703ENST00000524974NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
intron-intronENST00000493703ENST00000529945NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
intron-intronENST00000493703ENST00000530740NOTCH2chr1

120572529

-PDE4DIPchr1

145021167

-
intron-intronENST00000602566ENST00000313431NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
intron-intronENST00000602566ENST00000369345NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
intron-intronENST00000602566ENST00000478649NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
intron-intronENST00000602566ENST00000479408NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
intron-intronENST00000602566ENST00000493130NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
intron-intronENST00000602566ENST00000524974NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-
intron-intronENST00000602566ENST00000529945NOTCH2chr1

120466260

-PDE4DIPchr1

144994701

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000256646NOTCH2chr1120572529-ENST00000313382PDE4DIPchr1145021167-81123751670772353

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000256646ENST00000313382NOTCH2chr1120572529-PDE4DIPchr1145021167-0.0070547210.99294525

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Fusion Genomic Features for NOTCH2-PDE4DIP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NOTCH2-PDE4DIP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:120466260/chr1:144994701)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003133820461002_104362241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003133820461096_112462241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003133820461212_124062241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003133820461346_138562241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003133820461431_145562241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000313382046162_20562241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003133820461736_176062241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003133820461840_207762241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003133820462273_231262241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000313382046238_31862241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000313382046350_68462241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000031338204641_13262241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000313382046743_93662241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003134310191002_104301133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003134310191096_112401133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003134310191212_124001133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003134310191346_138501133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003134310191431_145501133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000313431019162_20501133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003134310191736_176001133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003134310191840_207701133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003134310192273_231201133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000313431019238_31801133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000313431019350_68401133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000031343101941_13201133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000313431019743_93601133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369347041002_10430174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369347041096_11240174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369347041212_12400174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369347041346_13850174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369347041431_14550174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000036934704162_2050174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369347041736_17600174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369347041840_20770174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369347042273_23120174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000036934704238_3180174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000036934704350_6840174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693470441_1320174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000036934704743_9360174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369348071002_104377311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369348071096_112477311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369348071212_124077311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369348071346_138577311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369348071431_145577311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000036934807162_20577311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369348071736_176077311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369348071840_207777311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369348072273_231277311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000036934807238_31877311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000036934807350_68477311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000036934807743_93677311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693490231002_10430970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693490231096_11240970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693490231212_12400970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693490231346_13850970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693490231431_14550970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369349023162_2050970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693490231736_17600970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693490231840_20770970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693490232273_23120970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369349023238_3180970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369349023350_6840970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000036934902341_1320970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369349023743_9360970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693510221002_10430989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693510221096_11240989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693510221212_12400989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693510221346_13850989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693510221431_14550989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369351022162_2050989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693510221736_17600989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693510221840_20770989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693510222273_23120989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369351022238_3180989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369351022350_6840989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000036935102241_1320989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369351022743_9360989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693540441002_104302347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693540441096_112402347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693540441212_124002347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693540441346_138502347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693540441431_145502347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369354044162_20502347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693540441736_176002347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693540441840_207702347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693540442273_231202347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369354044238_31802347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369354044350_68402347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000036935404441_13202347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369354044743_93602347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693560441002_104302363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693560441096_112402363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693560441212_124002363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693560441346_138502363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693560441431_145502363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369356044162_20502363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693560441736_176002363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693560441840_207702363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693560442273_231202363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369356044238_31802363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369356044350_68402363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST0000036935604441_13202363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369356044743_93602363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003133820461551_164262241.0DomainOlduvai
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003134310191551_164201133.0DomainOlduvai
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369347041551_16420174.0DomainOlduvai
TgenePDE4DIPchr1:120572529chr1:145021167ENST00000369348071551_164277311.0DomainOlduvai
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693490231551_16420970.0DomainOlduvai
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693510221551_16420989.0DomainOlduvai
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693540441551_164202347.0DomainOlduvai
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693560441551_164202363.0DomainOlduvai

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341645_1648512472.0Compositional biasNote=Poly-Ala
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341994_1997512472.0Compositional biasNote=Poly-Leu
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2342426_2429512472.0Compositional biasNote=Poly-Ser
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341025_1061512472.0DomainEGF-like 27%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234105_143512472.0DomainEGF-like 3
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341063_1099512472.0DomainEGF-like 28
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341101_1147512472.0DomainEGF-like 29
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341149_1185512472.0DomainEGF-like 30%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341187_1223512472.0DomainEGF-like 31%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341225_1262512472.0DomainEGF-like 32%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341264_1302512472.0DomainEGF-like 33
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341304_1343512472.0DomainEGF-like 34
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341374_1412512472.0DomainEGF-like 35
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234144_180512472.0DomainEGF-like 4
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234182_219512472.0DomainEGF-like 5%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234221_258512472.0DomainEGF-like 6
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234260_296512472.0DomainEGF-like 7%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-23426_63512472.0DomainEGF-like 1
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234298_336512472.0DomainEGF-like 8%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234338_374512472.0DomainEGF-like 9%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234375_413512472.0DomainEGF-like 10
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234415_454512472.0DomainEGF-like 11%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234456_492512472.0DomainEGF-like 12%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234494_530512472.0DomainEGF-like 13%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234532_568512472.0DomainEGF-like 14%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234570_605512472.0DomainEGF-like 15%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234607_643512472.0DomainEGF-like 16%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234645_680512472.0DomainEGF-like 17%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-23464_102512472.0DomainEGF-like 2
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234682_718512472.0DomainEGF-like 18%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234720_755512472.0DomainEGF-like 19
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234757_793512472.0DomainEGF-like 20%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234795_831512472.0DomainEGF-like 21%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234833_871512472.0DomainEGF-like 22
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234873_909512472.0DomainEGF-like 23%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234911_947512472.0DomainEGF-like 24%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234949_985512472.0DomainEGF-like 25%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-234987_1023512472.0DomainEGF-like 26%3B calcium-binding
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341425_1677512472.0RegionNote=Negative regulatory region (NRR)
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341425_1465512472.0RepeatNote=LNR 1
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341466_1502512472.0RepeatNote=LNR 2
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341503_1544512472.0RepeatNote=LNR 3
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341827_1871512472.0RepeatNote=ANK 1
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341876_1905512472.0RepeatNote=ANK 2
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341909_1939512472.0RepeatNote=ANK 3
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341943_1972512472.0RepeatNote=ANK 4
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341976_2005512472.0RepeatNote=ANK 5
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2342009_2038512472.0RepeatNote=ANK 6
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341699_2471512472.0Topological domainCytoplasmic
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-23426_1677512472.0Topological domainExtracellular
HgeneNOTCH2chr1:120572529chr1:145021167ENST00000256646-2341678_1698512472.0TransmembraneHelical
TgenePDE4DIPchr1:120572529chr1:145021167ENST000003693480741_13277311.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for NOTCH2-PDE4DIP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>59764_59764_1_NOTCH2-PDE4DIP_NOTCH2_chr1_120572529_ENST00000256646_PDE4DIP_chr1_145021167_ENST00000313382_length(transcript)=8112nt_BP=375nt
AAACTTCGGGCGGCGGCTGAGGCGGCGGCCGAGGAGCGGCGGACTCGGGGCGCGGGGAGTCGAGGCATTTGCGCCTGGGCTTCGGAGCGT
AGCGCCAGGGCCTGAGCCTTTGAAGCAGGAGGAGGGGAGGAGAGAGTGGGGCTCCTCTATCGGGACCCCCTCCCCATGTGGATCTGCCCA
GGCGGCGGCGGCGGCGGCGGAGGAGGAGGCGACCGAGAAGATGCCCGCCCTGCGCCCCGCTCTGCTGTGGGCGCTGCTGGCGCTCTGGCT
GTGCTGCGCGGCCCCCGCGCATGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAGGAATGTGTGTTACCTACCACAATGG
CACAGGATACTGCAAAGATTATTTTGCAGAGGATGATGGGGAGATGGTACCCAGAACGAGTCACACAGCAGCTTTTCTTAGTGACACTAA
AGATCGAGGCCCTCCAGTGCAGTCACAGATCTGGAGAAGTGGTGAAAAGGTCCCGTTTGTGCAGACATATTCCTTGAGAGCATTTGAGAA
ACCCCCTCAGGTACAGACCCAGGCTCTTCGAGACTTTGAGAAGCACCTCAATGACCTGAAGAAGGAGAACTTCAGCCTCAAGCTGCGCAT
CTACTTCCTGGAGGAGCGCATGCAACAGAAGTATGAGGCCAGCCGGGAGGACATCTACAAGCGGAACATTGAGCTGAAGGTTGAAGTGGA
GAGCTTGAAACGAGAACTCCAGGACAAGAAACAGCATCTGGATAAAACATGGGCTGATGTGGAGAATCTCAACAGTCAGAATGAAGCTGA
GCTCCGACGCCAGTTTGAGGAGCGACAGCAGGAGACGGAGCATGTTTATGAGCTCTTGGAGAATAAGATCCAGCTTCTGCAGGAGGAATC
CAGGCTAGCAAAGAATGAAGCTGCGCGGATGGCAGCTCTGGTGGAAGCAGAGAAGGAGTGTAACCTGGAGCTCTCAGAGAAACTGAAGGG
AGTCACCAAAAACTGGGAAGATGTACCAGGAGACCAGGTCAAGCCCGACCAATACACTGAGGCCCTGGCCCAGAGGGACAAGAGAATTGA
AGAACTGAATCAGAGCCTGGCTGCCCAGGAGAGGCTTGTAGAACAGCTATCTCGGGAGAAACAACAACTGCTACATCTGTTGGAGGAGCC
AACTAGCATGGAAGTGCAGCCCATGACTGAAGAGTTGCTGAAACAACAAAAGCTGAATTCACATGAGACCACTATAACTCAGCAGTCTGT
ATCTGATTCCCACTTGGCAGAACTCCAGGAAAAAATCCAGCAAACAGAGGCCACCAACAAGATTCTTCAAGAGAAACTTAATGAAATGAG
CTATGAACTAAAGTGTGCTCAGGAGTCGTCTCAAAAGCAAGATGGTACAATTCAGAACCTCAAGGAAACTCTGAAAAGCAGGGAACGTGA
GACTGAGGAGTTGTACCAGGTAATTGAAGGTCAAAATGACACAATGGCAAAGCTTCGAGAAATGCTGCACCAAAGCCAGCTTGGACAACT
TCACAGCTCAGAGGGTACTTCTCCAGCTCAGCAACAGGTAGCTCTGCTTGATCTTCAGAGTGCTTTATTCTGCAGCCAACTTGAAATACA
GAAGCTCCAGAGGGTGGTACGACAGAAAGAGCGCCAACTGGCTGATGCCAAACAATGTGTGCAATTTGTAGAGGCTGCAGCACACGAGAG
TGAACAGCAGAAAGAGGCTTCTTGGAAACATAACCAGGAATTGCGAAAAGCCTTGCAGCAGCTACAAGAAGAATTGCAGAATAAGAGCCA
ACAGCTTCGTGCCTGGGAGGCTGAAAAATACAATGAGATTCGAACCCAGGAACAAAACATCCAGCACCTAAACCATAGTCTGAGTCACAA
GGAGCAGTTGCTTCAGGAATTTCGGGAGCTCCTACAGTATCGAGATAACTCAGACAAAACCCTTGAAGCAAATGAAATGTTGCTTGAGAA
ACTTCGCCAGCGAATACATGATAAAGCTGTTGCTCTGGAGCGGGCTATAGATGAAAAATTCTCTGCTCTAGAAGAGAAAGAAAAAGAACT
GCGCCAGCTTCGTCTTGCTGTGAGAGAGCGAGATCATGACTTAGAGAGACTGCGCGATGTCCTCTCCTCCAATGAAGCTACTATGCAAAG
TATGGAGAGTCTCCTGAGGGCCAAAGGCCTGGAAGTGGAACAGTTATCTACTACCTGTCAAAACCTCCAGTGGCTGAAAGAAGAAATGGA
AACCAAATTTAGCCGTTGGCAGAAGGAACAAGAGAGTATCATTCAGCAGTTACAGACGTCTCTTCATGATAGGAACAAAGAAGTGGAGGA
TCTTAGTGCAACACTGCTCTGCAAACTTGGACCAGGGCAGAGTGAGATAGCAGAGGAGCTGTGCCAGCGTCTACAGCGAAAGGAAAGGAT
GCTGCAGGACCTTCTAAGTGATCGAAATAAACAAGTGCTGGAACATGAAATGGAGATTCAAGGCCTGCTTCAGTCTGTGAGCACCAGGGA
GCAGGAAAGCCAAGCTGCTGCAGAGAAGTTGGTGCAAGCCTTAATGGAAAGAAATTCAGAATTACAGGCCCTGCGCCAATATTTAGGAGG
GAGAGACTCCCTGATGTCCCAAGCACCCATCTCTAACCAACAAGCTGAAGTTACCCCCACTGGCTGTCTTGGAAAACAGACTGATCAAGG
TTCAATGCAGATACCTTCCAGAGATGATAGCACTTCATTGACTGCCAAAGAGGATGTCAGCATACCCAGATCCACATTAGGAGACTTGGA
CACAGTTGCAGGGCTGGAAAAAGAACTGAGTAATGCCAAAGAGGAACTTGAACTCATGGCTAAAAAAGAAAGAGAAAGTCAGATGGAACT
TTCTGCTCTACAGTCCATGATGGCTGTGCAGGAAGAAGAGCTGCAGGTGCAGGCTGCTGATATGGAGTCTCTGACCAGGAACATACAGAT
TAAAGAAGATCTCATAAAGGACCTGCAAATGCAACTGGTTGATCCTGAAGACATACCAGCTATGGAACGCCTGACCCAGGAAGTCTTACT
TCTTCGGGAAAAAGTTGCTTCAGTAGAATCCCAGGGTCAAGAAATTTCAGGAAACCGAAGACAACAGTTGCTGCTGATGCTAGAAGGACT
AGTAGATGAACGGAGTCGGCTCAATGAGGCCTTACAAGCAGAGAGACAGCTCTATAGCAGTCTGGTGAAGTTCCATGCCCATCCAGAGAG
CTCTGAGAGAGACCGAACTCTGCAGGTGGAACTGGAAGGGGCTCAGGTGTTACGCAGTCGGCTAGAAGAAGTTCTTGGAAGAAGCTTGGA
GCGCTTAAACAGGCTGGAGACCCTGGCCGCCATTGGAGGTGCAGCTGCAGGGGATGACACCGAAGATACAAGCACTGAGTTCACTGACAG
TATTGAGGAGGAGGCTGCACACCATAGTCACCAGCAACTTGTCAAGGTGGCTTTGGAGAAAAGTCTGGCAACTGTGGAGACCCAGAACCC
ATCTTTTTCCCCTCCTTCTCCGATGGGAGGGGACAGTAACAGGTGTCTTCAGGAAGAAATGCTCCACCTGAGGGCTGAGTTCCACCAGCA
CTTAGAAGAGAAGAGGAAAGCTGAGGAGGAACTGAAGGAGCTAAAGGCTCAAATTGAGGAAGCAGGATTCTCCTCAGTGTCCCACATCAG
GAACACCATGCTGAGCCTTTGCCTTGAGAATGCGGAGCTGAAAGAGCAGATGGGAGAAGCAATGTCTGATGGATGGGAGATCGAGGAAGA
CAAGGAGAAGGGCGAGTTGGATAACCAGTCCCAGCCTCGTGACCCTGGGCCTCAGTCAGCGTTTAGCCTACCAGGGTCCACCCAGCACCT
GCGCTCCCAGCTGTCACAATGCAAACAACGCTATCAAGATCTCCAGGAGAAGCTGCTGCTATCAGAAGCCACTGTCTTTGCTCAGGCTAA
CGAGCTGGAGAAATACAGAGTTATGCTTACAGGTGAATCCTTGGTGAAGCAGGACAGCAAGCAGATCCAGGTGGACCTCCAGGACCTGGG
CTATGAGACTTGTGGCCGAAGCGAGAATGAGGCTGAACGGGAGGAAACCACCAGTCCTGAGTGTGAGGAGCACAACAGCCTCAAGGAAAT
GGTCCTGATGGAGGGGCTGTGCTCTGAGCAGGGACGCCGGGGCTCAACACTGGCTAGTTCCTCTGAGAGGAAGCCCTTGGAGAACCAGCT
AGGGAAGCAGGAAGAGTTCCGGGTATATGGAAAGTCAGAAAACATCTTGGTCCTACGAAAGGACATCAAAGATCTGAAGGCCCAGCTGCA
GAATGCCAACAAGGTCATTCAAAACCTCAAGAGCCGGGTCCGGTCCCTCTCAGTTACAAGTGATTATTCGTCTAGTCTGGAAAGACCCTG
GAAGCTGAGAGCTGTTGGCACCTTGGAGGGGTCTTCACCTCATAGTGTCCCTGATGAGGATGAGGGGTGGCTGTCTGATGGCACTGGGGC
TTTCTACTCTCCAGGGCTTCAGGCCAAAAAGGACCTGGAGAGTCTCATCCAGAGAGTATCCCAGCTGGAGGCCCAGCTCCCAAAAAATGG
ACTAGAAGAGAAGCTGGCTGAGGAGCTGAGATCAGCCTCGTGGCCTGGGAAATATGATTCCCTGATTCAGGATCAGGCCCGGGAACTGTC
TTACCTACGGCAAAAAATACGAGAAGGGAGAGGTATTTGTTATCTTATCACCCGGCATGCAAAAGATACAGTAAAATCTTTTGAGGATCT
CCTAAGGAGCAATGACATTGACTACTACCTGGGACAGAGCTTCCGGGAGCAACTCGCCCAGGGAAGCCAGCTGACAGAGAGGCTCACCAG
CAAACTCAGCACCAAGGATCATAAAAGTGAGAAAGATCAAGCTGGACTTGAGCCACTGGCCCTCAGGCTCAGCAGGGAGCTGCAGGAGAA
GGAGAAAGTGATTGAAGTCCTGCAGGCCAAGCTGGATGCTCGGTCCCTCACACCCTCCAGCAGCCATGCCTTGTCTGACTCCCACCGCTC
TCCCAGCAGCACCTCTTTCCTGTCTGATGAACTGGAAGCCTGCTCTGACATGGACATAGTCAGCGAGTACACACACTATGAAGAGAAGAA
AGCTTCTCCCAGTCACTCAGATTCCATCCATCATTCGAGTCATTCTGCTGTGTTGTCTTCTAAACCATCATCAACCAGTGCATCTCAGGG
GGCTAAGGCCGAATCCAACAGCAACCCCATCAGCTTGCCAACTCCCCAGAATACCCCCAAGGAGGCCAACCAGGCCCATTCAGGTGCCAG
CACTGTTCCTCCTGCTTCCACAGCTACATTGCTGAGCAACGACTTGGAAGCCGACTCTTCCTACTACCTCAACTCTGCCCAGCCTCACTC
TCCTCCAAGGGGCACCATAGAACTGGGAAGAATCCTAGAGCCTGGGTACCTGGGCAGCAGTGGCAAGTGGGATGTGATGAGGCCTCAGAA
AGGGAGTGTATCTGGGGACCTATCCTCAGGCTCCTCTGTGTACCAGCTTAACTCCAAACCCACAGGGGCTGACCTGCTGGAAGAGCATCT
TGGTGAAATCCGGAACCTGCGCCAGCGCCTGGAGGAATCCATCTGCATCAATGACCGCCTACGGGAGCAACTGGAACACCGGCTGACCTC
TACTGCTCGTGGAAGGGGATCCACTTCTAACTTCTACAGTCAGGGCCTGGAGTCCATACCTCAGCTCTGCAATGAGAACAGAGTCCTCAG
GGAAGACAATCGAAGACTTCAGGCTCAACTGAGTCATGTTTCCAGAGAGCACTCCCAGGAAACAGAAAGCCTGAGGGAGGCTCTGCTGTC
CTCTCGATCCCACCTTCAAGAGCTGGAAAAGGAGCTGGAGCACCAGAAGGTGGAAAGGCAGCAGCTTTTGGAAGACTTGAGGGAGAAGCA
GCAAGAGGTCTTGCATTTCAGGGAGGAACGTCTTTCCCTCCAGGAAAACGACTCCAGACTGCAGCACAAGCTGGTTCTCCTGCAGCAACA
GTGTGAAGAGAAACAGCAGCTCTTTGAGTCCCTCCAGTCAGAGCTACAAATCTACGAGGCACTTTATGGCAATTCCAAGAAGGGGCTGAA
AGCTTACAGCCTGGATGCCTGTCACCAAATCCCTTTGAGCAGTGACCTGAGCCACCTGGTGGCAGAGGTACGAGCTCTGAGAGGGCAGCT
GGAGCAGAGCATTCAGGGGAACAATTGTCTGCGACTGCAGCTGCAACAGCAGCTGGAGAGCGGTGCTGGCAAAGCCAGCCTCAGCCCCTC
CTCCATTAACCAGAACTTCCCAGCCAGCACTGACCCTGGAAACAAGCAGCTGCTCCTCCAAGATTCAGCTGTGTCCCCTCCAGTCCGGGA
TGTTGGTATGAATTCCCCAGCTCTGGTCTTCCCCAGCTCTGCTTCCTCTACTCCTGGCTCAGAAACGCCCATAATCAACAGAGCAAATGG
CTTGGGTTTGGATACTTCTCCAGTAATGAAGACCCCTCCCAAGCTAGAGGGTGATGCTACTGATGGCTCCTTTGCCAATAAGCATGGCCG
CCATGTCATTGGCCACATTGATGACTACAGTGCCCTAAGACAGCAGATTGCGGAGGGCAAGCTGCTGGTCAAAAAGATAGTGTCTCTTGT
GAGATCAGCGTGCAGCTTCCCTGGCCTTGAAGCCCAAGGCACAGAGGTGCTAGGCAGCAAAGGTATTCATGAGCTTCGGAGCAGCACCAG
TGCCCTGCACCATGCCCTAGAGGAGTCAGCTTCCCTCCTCACCATGTTCTGGAGAGCGGCCCTGCCAAGCACCCACATCCCTGTGCTGCC
TGGCAAAGTGGGAGAATCAACAGAAAGGGAACTTCTGGAACTGAGAACCAAAGTATCCAAACAGGAGCGACTCCTTCAGAGCACAACTGA
GCATCTGAAGAACGCCAACCAGCAGAAGGAGAGCATGGAACAGTTCATTGTCAGCCAGCTAACCAGAACACATGATGTTTTAAAGAAGGC
AAGGACTAACTTAGAGGTGAAATCCCTAAGGGCTCTGCCATGTACTCCAGCCTTGTGACCCTTGCCTTCCAGGAACCATGCAAGAAGCGC
AGCCACCAGAAGTCCTTAAAACAGCAGGAAAGGTGGGCCTGTCCCCCTTTTGTGCAGCTACCTATCTGCTGAGGAGCATCTGGGCCTCAT
TCCTCCAAGTCCACGGGAGGGTCCAGAAGAGGGAGTCAGAGATGTATCCTGGTGGAGCTGGGAGAAAGGCAGAAAGCCTTTCTGACGGCT
ATGGAATACGATTAGCCAAGGTCCACTTGGCCCAGCACTAAGAAAAAGATGCGTAGTTTGCACAGAAGGTTTTGTGATCCTGCCTCTCAA
CAGCCCCAGCAGCTTGGGAACTAGCAAGAGCACATTTCTTGCCTCATCAGCTGTCCTGAGATGGAAAACTCAGTGAATATAGGACCCTGA
TTCCGATGAAAGGGGCACGTGGTCCCAATGCTGGAGCTCCTCTGGCAGGTTCTAAAAGCACACTACTGAGCAGCGGTGCCCTGCCGGACA
CTGCTGGCGGGGGCTCAGTGAGCACTACTCACAGATCCACACCTGACCCTGTTGGGTCGAGTCAGGCTGGGCCTTGGTCTGCACTGTAGC
ACCTGTGTTCTTTGAGTTCACATCATGAATGTGGTGACTTCCCAGATACCATCTCAGGCTTAACCTAGCACATCCTATTTCTTTTCTTCT
ATGATATCCAAATTGGACTGACCTCACTTCAAAGTTGCTGTCCCATTTTGTCACCCTATCTTATCTCGGGGAAATTGCAGACTGATGGCC
AGACCAACTCTGTTGAAATTCTTGCATAGAGCAAACCTGTGCTCATTTTTAAGTGGCATGGGAGAGGCCCCAAGCCTAGTAAAGCCTAGT
CTGTGTCTTCACAGTGCTGGTAGAATGTGTTTGTGTGTATAAATATATGATATAGATTTATATATGTTGCTAACGCCATATATTGAAGGC
CAACATAACTGGTGGACAGGGTGGGTGACAGAAAATGAAAGTCTTTTTGGTGATTGTTAAAGCAAGATGTGTATAAAGAAATAAATAGTT

>59764_59764_1_NOTCH2-PDE4DIP_NOTCH2_chr1_120572529_ENST00000256646_PDE4DIP_chr1_145021167_ENST00000313382_length(amino acids)=2353AA_BP=120
MRRRPRSGGLGARGVEAFAPGLRSVAPGPEPLKQEEGRREWGSSIGTPSPCGSAQAAAAAAEEEATEKMPALRPALLWALLALWLCCAAP
AHALQCRDGYEPCVNEGMCVTYHNGTGYCKDYFAEDDGEMVPRTSHTAAFLSDTKDRGPPVQSQIWRSGEKVPFVQTYSLRAFEKPPQVQ
TQALRDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQF
EERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQS
LAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKC
AQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRV
VRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQ
EFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLL
RAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLL
SDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIP
SRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLI
KDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDR
TLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPP
SPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGE
LDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCG
RSENEAEREETTSPECEEHNSLKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQNANKV
IQNLKSRVRSLSVTSDYSSSLERPWKLRAVGTLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKL
AEELRSASWPGKYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTK
DHKSEKDQAGLEPLALRLSRELQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSH
SDSIHHSSHSAVLSSKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQAHSGASTVPPASTATLLSNDLEADSSYYLNSAQPHSPPRGT
IELGRILEPGYLGSSGKWDVMRPQKGSVSGDLSSGSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGR
GSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLH
FREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQ
GNNCLRLQLQQQLESGAGKASLSPSSINQNFPASTDPGNKQLLLQDSAVSPPVRDVGMNSPALVFPSSASSTPGSETPIINRANGLGLDT
SPVMKTPPKLEGDATDGSFANKHGRHVIGHIDDYSALRQQIAEGKLLVKKIVSLVRSACSFPGLEAQGTEVLGSKGIHELRSSTSALHHA
LEESASLLTMFWRAALPSTHIPVLPGKVGESTERELLELRTKVSKQERLLQSTTEHLKNANQQKESMEQFIVSQLTRTHDVLKKARTNLE

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Fusion Gene PPI Analysis for NOTCH2-PDE4DIP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NOTCH2-PDE4DIP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NOTCH2-PDE4DIP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource