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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGAP1-MYL6 (FusionGDB2 ID:5980)

Fusion Gene Summary for ARHGAP1-MYL6

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP1-MYL6
Fusion gene ID: 5980
HgeneTgene
Gene symbol

ARHGAP1

MYL6

Gene ID

392

4637

Gene nameRho GTPase activating protein 1myosin light chain 6
SynonymsCDC42GAP|RHOGAP|RHOGAP1|p50rhoGAPESMLC|LC17|LC17-GI|LC17-NM|LC17A|LC17B|MLC-3|MLC1SM|MLC3NM|MLC3SM
Cytomap

11p11.2

12q13.2

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 1CDC42 GTPase-activating proteinGTPase-activating protein rhoGAPGTPase-activating protein rhoOGAPGTPase-activating protein, Rho, 1rho-related small GTPase protein activatorrho-type GTPase-activating protein 1myosin light polypeptide 617 kDa myosin light chainmyosin light chain A3myosin light chain alkali 3myosin, light chain 6, alkali, smooth muscle and non-musclemyosin, light polypeptide 6, alkali, smooth muscle and non-muscle
Modification date2020031320200313
UniProtAcc

Q07960

P14649

Ensembl transtripts involved in fusion geneENST00000311956, ENST00000549017, 
ENST00000293422, ENST00000348108, 
ENST00000536128, ENST00000547408, 
ENST00000547649, ENST00000548293, 
ENST00000548400, ENST00000548580, 
ENST00000549566, ENST00000551589, 
ENST00000551954, ENST00000550697, 
Fusion gene scores* DoF score8 X 8 X 6=38417 X 20 X 7=2380
# samples 820
** MAII scorelog2(8/384*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/2380*10)=-3.57288966842058
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP1 [Title/Abstract] AND MYL6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP1(46700914)-MYL6(56553370), # samples:1
ARHGAP1(46700915)-MYL6(56553371), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGAP1

GO:0007264

small GTPase mediated signal transduction

8253717|8288572


check buttonFusion gene breakpoints across ARHGAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MYL6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-A4Z0-01AARHGAP1chr11

46700915

-MYL6chr12

56553371

+
ChimerDB4STADTCGA-D7-A4Z0ARHGAP1chr11

46700914

-MYL6chr12

56553370

+


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Fusion Gene ORF analysis for ARHGAP1-MYL6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000311956ENST00000549017ARHGAP1chr11

46700915

-MYL6chr12

56553371

+
5CDS-5UTRENST00000311956ENST00000549017ARHGAP1chr11

46700914

-MYL6chr12

56553370

+
5CDS-intronENST00000311956ENST00000293422ARHGAP1chr11

46700915

-MYL6chr12

56553371

+
5CDS-intronENST00000311956ENST00000293422ARHGAP1chr11

46700914

-MYL6chr12

56553370

+
5CDS-intronENST00000311956ENST00000348108ARHGAP1chr11

46700915

-MYL6chr12

56553371

+
5CDS-intronENST00000311956ENST00000348108ARHGAP1chr11

46700914

-MYL6chr12

56553370

+
5CDS-intronENST00000311956ENST00000536128ARHGAP1chr11

46700915

-MYL6chr12

56553371

+
5CDS-intronENST00000311956ENST00000536128ARHGAP1chr11

46700914

-MYL6chr12

56553370

+
5CDS-intronENST00000311956ENST00000547408ARHGAP1chr11

46700915

-MYL6chr12

56553371

+
5CDS-intronENST00000311956ENST00000547408ARHGAP1chr11

46700914

-MYL6chr12

56553370

+
5CDS-intronENST00000311956ENST00000547649ARHGAP1chr11

46700915

-MYL6chr12

56553371

+
5CDS-intronENST00000311956ENST00000547649ARHGAP1chr11

46700914

-MYL6chr12

56553370

+
5CDS-intronENST00000311956ENST00000548293ARHGAP1chr11

46700915

-MYL6chr12

56553371

+
5CDS-intronENST00000311956ENST00000548293ARHGAP1chr11

46700914

-MYL6chr12

56553370

+
5CDS-intronENST00000311956ENST00000548400ARHGAP1chr11

46700915

-MYL6chr12

56553371

+
5CDS-intronENST00000311956ENST00000548400ARHGAP1chr11

46700914

-MYL6chr12

56553370

+
5CDS-intronENST00000311956ENST00000548580ARHGAP1chr11

46700915

-MYL6chr12

56553371

+
5CDS-intronENST00000311956ENST00000548580ARHGAP1chr11

46700914

-MYL6chr12

56553370

+
5CDS-intronENST00000311956ENST00000549566ARHGAP1chr11

46700915

-MYL6chr12

56553371

+
5CDS-intronENST00000311956ENST00000549566ARHGAP1chr11

46700914

-MYL6chr12

56553370

+
5CDS-intronENST00000311956ENST00000551589ARHGAP1chr11

46700915

-MYL6chr12

56553371

+
5CDS-intronENST00000311956ENST00000551589ARHGAP1chr11

46700914

-MYL6chr12

56553370

+
5CDS-intronENST00000311956ENST00000551954ARHGAP1chr11

46700915

-MYL6chr12

56553371

+
5CDS-intronENST00000311956ENST00000551954ARHGAP1chr11

46700914

-MYL6chr12

56553370

+
In-frameENST00000311956ENST00000550697ARHGAP1chr11

46700915

-MYL6chr12

56553371

+
In-frameENST00000311956ENST00000550697ARHGAP1chr11

46700914

-MYL6chr12

56553370

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000311956ARHGAP1chr1146700914-ENST00000550697MYL6chr1256553370+1858122921303433
ENST00000311956ARHGAP1chr1146700915-ENST00000550697MYL6chr1256553371+1858122921303433

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000311956ENST00000550697ARHGAP1chr1146700914-MYL6chr1256553370+0.0073207550.99267924
ENST00000311956ENST00000550697ARHGAP1chr1146700915-MYL6chr1256553371+0.0073207550.99267924

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Fusion Genomic Features for ARHGAP1-MYL6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARHGAP1chr1146700914-MYL6chr1256553370+0.0028313520.9971686
ARHGAP1chr1146700914-MYL6chr1256553370+0.0028313520.9971686
ARHGAP1chr1146700914-MYL6chr1256553370+0.0028313520.9971686
ARHGAP1chr1146700914-MYL6chr1256553370+0.0028313520.9971686

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARHGAP1-MYL6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:46700914/chr12:56553370)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP1

Q07960

MYL6

P14649

FUNCTION: GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.FUNCTION: Regulatory light chain of myosin. Does not bind calcium.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP1chr11:46700914chr12:56553370ENST00000311956-121363_218377440.0DomainCRAL-TRIO
HgeneARHGAP1chr11:46700915chr12:56553371ENST00000311956-121363_218377440.0DomainCRAL-TRIO
HgeneARHGAP1chr11:46700914chr12:56553370ENST00000311956-1213228_238377440.0MotifNote=SH3-binding
HgeneARHGAP1chr11:46700915chr12:56553371ENST00000311956-1213228_238377440.0MotifNote=SH3-binding
TgeneMYL6chr11:46700914chr12:56553370ENST0000054764916119_15110152.0DomainEF-hand 3
TgeneMYL6chr11:46700914chr12:56553370ENST000005476491684_11910152.0DomainEF-hand 2
TgeneMYL6chr11:46700914chr12:56553370ENST0000054829316119_15110152.0DomainEF-hand 3
TgeneMYL6chr11:46700914chr12:56553370ENST000005482931684_11910152.0DomainEF-hand 2
TgeneMYL6chr11:46700914chr12:56553370ENST0000055069717119_15110133.33333333333334DomainEF-hand 3
TgeneMYL6chr11:46700914chr12:56553370ENST000005506971784_11910133.33333333333334DomainEF-hand 2
TgeneMYL6chr11:46700915chr12:56553371ENST0000054764916119_15110152.0DomainEF-hand 3
TgeneMYL6chr11:46700915chr12:56553371ENST000005476491684_11910152.0DomainEF-hand 2
TgeneMYL6chr11:46700915chr12:56553371ENST0000054829316119_15110152.0DomainEF-hand 3
TgeneMYL6chr11:46700915chr12:56553371ENST000005482931684_11910152.0DomainEF-hand 2
TgeneMYL6chr11:46700915chr12:56553371ENST0000055069717119_15110133.33333333333334DomainEF-hand 3
TgeneMYL6chr11:46700915chr12:56553371ENST000005506971784_11910133.33333333333334DomainEF-hand 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP1chr11:46700914chr12:56553370ENST00000311956-1213244_431377440.0DomainRho-GAP
HgeneARHGAP1chr11:46700915chr12:56553371ENST00000311956-1213244_431377440.0DomainRho-GAP
TgeneMYL6chr11:46700914chr12:56553370ENST00000547649167_4210152.0DomainEF-hand 1
TgeneMYL6chr11:46700914chr12:56553370ENST00000548293167_4210152.0DomainEF-hand 1
TgeneMYL6chr11:46700914chr12:56553370ENST00000550697177_4210133.33333333333334DomainEF-hand 1
TgeneMYL6chr11:46700915chr12:56553371ENST00000547649167_4210152.0DomainEF-hand 1
TgeneMYL6chr11:46700915chr12:56553371ENST00000548293167_4210152.0DomainEF-hand 1
TgeneMYL6chr11:46700915chr12:56553371ENST00000550697177_4210133.33333333333334DomainEF-hand 1


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Fusion Gene Sequence for ARHGAP1-MYL6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5980_5980_1_ARHGAP1-MYL6_ARHGAP1_chr11_46700914_ENST00000311956_MYL6_chr12_56553370_ENST00000550697_length(transcript)=1858nt_BP=1229nt
GTTTGCCGAGCCTTGACAGGCGTGGCAGAGGGAGCAGTGCCCGAGCGCGGTTTCTCTTAAGGTTCTGCAGGGCAAGGCTGTCTGGGACAG
GCTTGGCCATGGATCCGCTCTCAGAGCTGCAGGATGATCTGACCTTGGATGACACCAGCGAGGCTCTGAACCAGCTGAAGCTGGCCTCCA
TCGATGAGAAGAACTGGCCCTCGGATGAAATGCCTGACTTCCCCAAGTCAGATGACTCCAAAAGCAGCTCCCCGGAACTTGTCACACACC
TGAAGTGGGATGACCCATACTATGACATCGCCCGGCACCAGATCGTGGAGGTGGCAGGAGATGACAAGTATGGGCGGAAGATCATTGTGT
TTAGTGCCTGTCGAATGCCCCCCAGCCACCAGCTCGACCACAGCAAGCTCCTGGGGTACCTGAAGCACACCCTGGACCAGTACGTGGAGA
GTGACTACACACTTCTGTATCTGCACCACGGCCTGACCAGCGACAACAAGCCCTCCCTCAGCTGGCTCCGTGATGCCTACCGGGAGTTTG
ACCGCAAGTACAAGAAAAACATCAAGGCCTTGTACATCGTGCATCCAACCATGTTCATCAAAACTCTGCTCATCCTCTTCAAGCCCCTCA
TCAGCTTCAAGTTCGGGCAGAAGATCTTCTATGTGAATTACCTGAGCGAGCTGAGCGAGCACGTGAAGCTGGAGCAGCTGGGGATCCCTC
GCCAAGTGCTCAAATATGACGACTTCCTGAAATCCACACAGAAGAGCCCCGCGACAGCCCCCAAGCCCATGCCCCCACGGCCCCCCCTGC
CCAACCAGCAGTTTGGAGTCTCGCTGCAGCACCTCCAGGAGAAGAATCCAGAGCAGGAGCCCATTCCCATTGTACTCAGGGAGACTGTTG
CCTACTTACAGGCCCACGCTCTCACCACCGAGGGCATCTTCCGGAGGTCGGCCAACACCCAAGTGGTCCGGGAAGTGCAGCAGAAGTACA
ACATGGGGCTGCCTGTGGATTTCGACCAGTACAATGAGCTGCACCTGCCAGCAGTCATCCTCAAGACCTTCCTCCGGGAGCTTCCTGAGC
CCCTGCTCACCTTTGACCTCTACCCCCATGTGGTGGGCTTCCTCAACATTGATGAAAGCCAGAGGGTGCCAGCGACACTGCAGGTCCTCC
AGACGCTGCCCGAGGAGAACTACCAGGTGCTTCGTTTCCTGACTGCTTTCCTGGTGCAGAGTTCAAGGAGGCCTTCCAGCTGTTTGACCG
AACAGGTGATGGCAAGATCCTGTACAGCCAGTGTGGGGATGTGATGAGGGCCCTGGGCCAGAACCCTACCAACGCCGAGGTGCTCAAGGT
CCTGGGGAACCCCAAGAGTGATGAGATGAATGTGAAGGTGCTGGACTTTGAGCACTTTCTGCCCATGCTGCAGACAGTGGCCAAGAACAA
GGACCAGGGCACCTATGAGGATTATGTCGAAGGACTTCGGGTGTTTGACAAGGAAGGAAATGGCACCGTCATGGGTGCTGAAATCCGGCA
TGTTCTTGTCACACTGGGTGAGAAGATGACAGAGGAAGAAGTAGAGATGCTGGTGGCAGGGCATGAGGACAGCAATGGTTGTATCAACTA
TGAAGCGTTTGTGAGGCATATCCTGTCGGGGTGACGGGCCCATGGGGCGGAGCTCGTCCGCATGGTGCTGAATGGCTGAGGACCTTCCCA
GTCTCCCCAGAGTCCGTGCCTTTCCCTGTGTGAATTTTGTATCTAGCCTAAAGTTTCCCTAGGCTTTCTTGTCTCAGCAACTTTCCCATC

>5980_5980_1_ARHGAP1-MYL6_ARHGAP1_chr11_46700914_ENST00000311956_MYL6_chr12_56553370_ENST00000550697_length(amino acids)=433AA_BP=408
LPSLDRRGRGSSARARFLLRFCRARLSGTGLAMDPLSELQDDLTLDDTSEALNQLKLASIDEKNWPSDEMPDFPKSDDSKSSSPELVTHL
KWDDPYYDIARHQIVEVAGDDKYGRKIIVFSACRMPPSHQLDHSKLLGYLKHTLDQYVESDYTLLYLHHGLTSDNKPSLSWLRDAYREFD
RKYKKNIKALYIVHPTMFIKTLLILFKPLISFKFGQKIFYVNYLSELSEHVKLEQLGIPRQVLKYDDFLKSTQKSPATAPKPMPPRPPLP
NQQFGVSLQHLQEKNPEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILKTFLRELPEP

--------------------------------------------------------------
>5980_5980_2_ARHGAP1-MYL6_ARHGAP1_chr11_46700915_ENST00000311956_MYL6_chr12_56553371_ENST00000550697_length(transcript)=1858nt_BP=1229nt
GTTTGCCGAGCCTTGACAGGCGTGGCAGAGGGAGCAGTGCCCGAGCGCGGTTTCTCTTAAGGTTCTGCAGGGCAAGGCTGTCTGGGACAG
GCTTGGCCATGGATCCGCTCTCAGAGCTGCAGGATGATCTGACCTTGGATGACACCAGCGAGGCTCTGAACCAGCTGAAGCTGGCCTCCA
TCGATGAGAAGAACTGGCCCTCGGATGAAATGCCTGACTTCCCCAAGTCAGATGACTCCAAAAGCAGCTCCCCGGAACTTGTCACACACC
TGAAGTGGGATGACCCATACTATGACATCGCCCGGCACCAGATCGTGGAGGTGGCAGGAGATGACAAGTATGGGCGGAAGATCATTGTGT
TTAGTGCCTGTCGAATGCCCCCCAGCCACCAGCTCGACCACAGCAAGCTCCTGGGGTACCTGAAGCACACCCTGGACCAGTACGTGGAGA
GTGACTACACACTTCTGTATCTGCACCACGGCCTGACCAGCGACAACAAGCCCTCCCTCAGCTGGCTCCGTGATGCCTACCGGGAGTTTG
ACCGCAAGTACAAGAAAAACATCAAGGCCTTGTACATCGTGCATCCAACCATGTTCATCAAAACTCTGCTCATCCTCTTCAAGCCCCTCA
TCAGCTTCAAGTTCGGGCAGAAGATCTTCTATGTGAATTACCTGAGCGAGCTGAGCGAGCACGTGAAGCTGGAGCAGCTGGGGATCCCTC
GCCAAGTGCTCAAATATGACGACTTCCTGAAATCCACACAGAAGAGCCCCGCGACAGCCCCCAAGCCCATGCCCCCACGGCCCCCCCTGC
CCAACCAGCAGTTTGGAGTCTCGCTGCAGCACCTCCAGGAGAAGAATCCAGAGCAGGAGCCCATTCCCATTGTACTCAGGGAGACTGTTG
CCTACTTACAGGCCCACGCTCTCACCACCGAGGGCATCTTCCGGAGGTCGGCCAACACCCAAGTGGTCCGGGAAGTGCAGCAGAAGTACA
ACATGGGGCTGCCTGTGGATTTCGACCAGTACAATGAGCTGCACCTGCCAGCAGTCATCCTCAAGACCTTCCTCCGGGAGCTTCCTGAGC
CCCTGCTCACCTTTGACCTCTACCCCCATGTGGTGGGCTTCCTCAACATTGATGAAAGCCAGAGGGTGCCAGCGACACTGCAGGTCCTCC
AGACGCTGCCCGAGGAGAACTACCAGGTGCTTCGTTTCCTGACTGCTTTCCTGGTGCAGAGTTCAAGGAGGCCTTCCAGCTGTTTGACCG
AACAGGTGATGGCAAGATCCTGTACAGCCAGTGTGGGGATGTGATGAGGGCCCTGGGCCAGAACCCTACCAACGCCGAGGTGCTCAAGGT
CCTGGGGAACCCCAAGAGTGATGAGATGAATGTGAAGGTGCTGGACTTTGAGCACTTTCTGCCCATGCTGCAGACAGTGGCCAAGAACAA
GGACCAGGGCACCTATGAGGATTATGTCGAAGGACTTCGGGTGTTTGACAAGGAAGGAAATGGCACCGTCATGGGTGCTGAAATCCGGCA
TGTTCTTGTCACACTGGGTGAGAAGATGACAGAGGAAGAAGTAGAGATGCTGGTGGCAGGGCATGAGGACAGCAATGGTTGTATCAACTA
TGAAGCGTTTGTGAGGCATATCCTGTCGGGGTGACGGGCCCATGGGGCGGAGCTCGTCCGCATGGTGCTGAATGGCTGAGGACCTTCCCA
GTCTCCCCAGAGTCCGTGCCTTTCCCTGTGTGAATTTTGTATCTAGCCTAAAGTTTCCCTAGGCTTTCTTGTCTCAGCAACTTTCCCATC

>5980_5980_2_ARHGAP1-MYL6_ARHGAP1_chr11_46700915_ENST00000311956_MYL6_chr12_56553371_ENST00000550697_length(amino acids)=433AA_BP=408
LPSLDRRGRGSSARARFLLRFCRARLSGTGLAMDPLSELQDDLTLDDTSEALNQLKLASIDEKNWPSDEMPDFPKSDDSKSSSPELVTHL
KWDDPYYDIARHQIVEVAGDDKYGRKIIVFSACRMPPSHQLDHSKLLGYLKHTLDQYVESDYTLLYLHHGLTSDNKPSLSWLRDAYREFD
RKYKKNIKALYIVHPTMFIKTLLILFKPLISFKFGQKIFYVNYLSELSEHVKLEQLGIPRQVLKYDDFLKSTQKSPATAPKPMPPRPPLP
NQQFGVSLQHLQEKNPEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILKTFLRELPEP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARHGAP1-MYL6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGAP1-MYL6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGAP1-MYL6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource