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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NOXO1-TPRN (FusionGDB2 ID:59818)

Fusion Gene Summary for NOXO1-TPRN

Fusion gene summary

Fusion gene information	Fusion gene name: NOXO1-TPRN
	Fusion gene ID: 59818
		Hgene	Tgene
	Gene symbol	NOXO1	TPRN
	Gene ID	124056	286262
	Gene name	NADPH oxidase organizer 1	taperin
	Synonyms	P41NOX\|P41NOXA\|P41NOXB\|P41NOXC\|SH3PXD5\|SNX28	C9orf75\|DFNB79
	Cytomap	16p13.3	9q34.3
	Type of gene	protein-coding	protein-coding
	Description	NADPH oxidase organizer 1NADPH oxidase regulatory proteinNox organizer 1SH3 and PX domain-containing protein 5nox-organizing protein 1regulatory protein P41NOX	taperin
	Modification date	20200313	20200313
	UniProtAcc	Q8NFA2	.
	Ensembl transtripts involved in fusion gene	ENST00000354249, ENST00000356120, ENST00000397280, ENST00000566005,	ENST00000541945, ENST00000321773, ENST00000409012,
Fusion gene scores	* DoF score	2 X 2 X 2=8	5 X 3 X 5=75
	# samples	2	6
	** MAII score	log2(2/8*10)=1.32192809488736	log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NOXO1 [Title/Abstract] AND TPRN [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NOXO1(2030940)-TPRN(140087143), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across NOXO1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TPRN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-IN-7808-01A	NOXO1	chr16	2030940	-	TPRN	chr9	140087143	-

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Fusion Gene ORF analysis for NOXO1-TPRN

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000354249	ENST00000541945	NOXO1	chr16	2030940	-	TPRN	chr9	140087143	-
5CDS-5UTR	ENST00000356120	ENST00000541945	NOXO1	chr16	2030940	-	TPRN	chr9	140087143	-
5CDS-5UTR	ENST00000397280	ENST00000541945	NOXO1	chr16	2030940	-	TPRN	chr9	140087143	-
5CDS-5UTR	ENST00000566005	ENST00000541945	NOXO1	chr16	2030940	-	TPRN	chr9	140087143	-
In-frame	ENST00000354249	ENST00000321773	NOXO1	chr16	2030940	-	TPRN	chr9	140087143	-
In-frame	ENST00000354249	ENST00000409012	NOXO1	chr16	2030940	-	TPRN	chr9	140087143	-
In-frame	ENST00000356120	ENST00000321773	NOXO1	chr16	2030940	-	TPRN	chr9	140087143	-
In-frame	ENST00000356120	ENST00000409012	NOXO1	chr16	2030940	-	TPRN	chr9	140087143	-
In-frame	ENST00000397280	ENST00000321773	NOXO1	chr16	2030940	-	TPRN	chr9	140087143	-
In-frame	ENST00000397280	ENST00000409012	NOXO1	chr16	2030940	-	TPRN	chr9	140087143	-
In-frame	ENST00000566005	ENST00000321773	NOXO1	chr16	2030940	-	TPRN	chr9	140087143	-
In-frame	ENST00000566005	ENST00000409012	NOXO1	chr16	2030940	-	TPRN	chr9	140087143	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000356120	NOXO1	chr16	2030940	-	ENST00000321773	TPRN	chr9	140087143	-	1425	435	685	2	228
ENST00000356120	NOXO1	chr16	2030940	-	ENST00000409012	TPRN	chr9	140087143	-	1341	435	685	2	228
ENST00000354249	NOXO1	chr16	2030940	-	ENST00000321773	TPRN	chr9	140087143	-	1507	517	767	78	229
ENST00000354249	NOXO1	chr16	2030940	-	ENST00000409012	TPRN	chr9	140087143	-	1423	517	767	78	229
ENST00000566005	NOXO1	chr16	2030940	-	ENST00000321773	TPRN	chr9	140087143	-	1141	151	4	645	213
ENST00000566005	NOXO1	chr16	2030940	-	ENST00000409012	TPRN	chr9	140087143	-	1057	151	4	561	185
ENST00000397280	NOXO1	chr16	2030940	-	ENST00000321773	TPRN	chr9	140087143	-	1141	151	4	645	213
ENST00000397280	NOXO1	chr16	2030940	-	ENST00000409012	TPRN	chr9	140087143	-	1057	151	4	561	185

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000356120	ENST00000321773	NOXO1	chr16	2030940	-	TPRN	chr9	140087143	-	0.006760373	0.99323964
ENST00000356120	ENST00000409012	NOXO1	chr16	2030940	-	TPRN	chr9	140087143	-	0.003106278	0.99689364
ENST00000354249	ENST00000321773	NOXO1	chr16	2030940	-	TPRN	chr9	140087143	-	0.005531719	0.9944682
ENST00000354249	ENST00000409012	NOXO1	chr16	2030940	-	TPRN	chr9	140087143	-	0.00298931	0.9970107
ENST00000566005	ENST00000321773	NOXO1	chr16	2030940	-	TPRN	chr9	140087143	-	0.006795014	0.99320495
ENST00000566005	ENST00000409012	NOXO1	chr16	2030940	-	TPRN	chr9	140087143	-	0.003193036	0.996807
ENST00000397280	ENST00000321773	NOXO1	chr16	2030940	-	TPRN	chr9	140087143	-	0.006795014	0.99320495
ENST00000397280	ENST00000409012	NOXO1	chr16	2030940	-	TPRN	chr9	140087143	-	0.003193036	0.996807

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Fusion Genomic Features for NOXO1-TPRN

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NOXO1-TPRN

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:2030940/chr9:140087143)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NOXO1 Q8NFA2	.
FUNCTION: Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. {ECO:0000269\|PubMed:12657628, ECO:0000269\|PubMed:14617635, ECO:0000269\|PubMed:15326186, ECO:0000269\|PubMed:15824103, ECO:0000269\|PubMed:15949904, ECO:0000269\|PubMed:16329988, ECO:0000269\|PubMed:17126813, ECO:0000269\|PubMed:19755710}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TPRN

chr16:2030940

chr9:140087143

ENST00000409012

590_627

575

712.0

Compositional bias

Note=Glu-rich

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NOXO1

chr16:2030940

chr9:140087143

ENST00000354249

163_225

371.0

Domain

SH3 1

Hgene

NOXO1

chr16:2030940

chr9:140087143

ENST00000354249

1_131

371.0

Domain

Hgene

NOXO1

chr16:2030940

chr9:140087143

ENST00000354249

237_296

371.0

Domain

SH3 2

Hgene

NOXO1

chr16:2030940

chr9:140087143

ENST00000356120

163_225

372.0

Domain

SH3 1

Hgene

NOXO1

chr16:2030940

chr9:140087143

ENST00000356120

1_131

372.0

Domain

Hgene

NOXO1

chr16:2030940

chr9:140087143

ENST00000356120

237_296

372.0

Domain

SH3 2

Hgene

NOXO1

chr16:2030940

chr9:140087143

ENST00000397280

163_225

377.0

Domain

SH3 1

Hgene

NOXO1

chr16:2030940

chr9:140087143

ENST00000397280

1_131

377.0

Domain

Hgene

NOXO1

chr16:2030940

chr9:140087143

ENST00000397280

237_296

377.0

Domain

SH3 2

Hgene

NOXO1

chr16:2030940

chr9:140087143

ENST00000566005

163_225

376.0

Domain

SH3 1

Hgene

NOXO1

chr16:2030940

chr9:140087143

ENST00000566005

1_131

376.0

Domain

Hgene

NOXO1

chr16:2030940

chr9:140087143

ENST00000566005

237_296

376.0

Domain

SH3 2

Tgene

TPRN

chr16:2030940

chr9:140087143

ENST00000409012

104_281

575

712.0

Compositional bias

Note=Pro-rich

Tgene

TPRN

chr16:2030940

chr9:140087143

ENST00000409012

528_533

575

712.0

Compositional bias

Note=Poly-Glu

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Fusion Gene Sequence for NOXO1-TPRN

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>59818_59818_1_NOXO1-TPRN_NOXO1_chr16_2030940_ENST00000354249_TPRN_chr9_140087143_ENST00000321773_length(transcript)=1507nt_BP=517nt
CTTCTCCTCCCTCCTCCTGTGGCCAGAGGCAGGCAGGAGGGCCCCAGGCAGCAGTCCCGCCTACCCTTCGCCCCTTCTTCAGTCTTGCAC
GCCTCCAGGGCTGGAAAGCTCATTCTTCTTCTTCCTCCCAGCAGCTCTGCCTGGAAGTCCCCCAATCCCTGTGCTCCTGCCCCCAGATCG
TGGGCTTGGGGGACAGCAAGAAAGCTGCAAAGGACTCAGCTGGGGCGGCTCCACAAGGACCCCACAGGCTTGAGGTGTTGCCAGGATTCT
ATCCCAGGGGGTTTTCTGGGTCCCCCAGAGCCCTCTCAAGCACGGGGAGGCAGAAGGGTCCTCGCCCATTTCAGGAATCTGCAGCCTGGA
AGCCACAGCCATGGCAGGCCCCCGATACCCAGTTTCAGTGCAAGGGGCAGCCCTGGTGCAGATCAAGAGGCTCCAAACGTTTGCCTTCTC
TGTGCGCTGGTCAGACGGCAGCGACACCTTCGTGCGCAGGAGTTGGGACGAATTCAGGCAGCTCAAGATGAAGATCTCCTTCAACGACAA
AAGCCTGCAGACCACATTTGAGTACCCTTCCGAGAGCTCCCTAGAGCAGGAGGAAGAGGTGGACCAGCAGGAGGAGGAGGAGGAGGAGGA
GGAGGAAGAGGAAGAGGAGGAAGAGGGATCCGGCTCAGAGGAGAAGCCCTTTGCACTCTTCCTGCCCCGGGCCACGTTTGTGAGCAGCGT
GAGACCCGAGAGCTCTCGGCTGCCAGAGGGTAGCTCAGGCCTGTCCAGCTACACCCCGAAGCACTCTGTGGCCTTCAGCAAGTGGCAGGA
GCAGGCGCTGGAGCAGGCCCCGAGGGAGGCAGAGCCCCCGCCCGTGGAGGCCATGGTGAGATGCGGGGGAGTGGAGCGCTGGGGGGAGTC
TGACACCCGGGCGAGCCCATGTGTCCACATTCTGTCCTCTCACTTTCAGCTCACACCCGCCAGTCAGAATGACCTCTCGGACTTCCGCAG
CGAGCCAGCCCTGTATTTCTGAGCCCAGCACTGCCAGGACCAAGGCTGAGCCCAGCTGTGGGAGTCCCGGAAGCTGGGCAGTAGCCAGGG
ACTACTGCACCCGCTTCTGCCTTGTTTGGCCTCACTGTATCCCACCCACCCCTCCTGGCCCTGGAAGCAGCTAGGGTGCCTCCTGCCATC
GGGGCCAGGTCTGGGTCTCACTCCCCGGCCCTGATTTGGGAGGGTCCAAGGGGGAAGTGGGGTGGGGAACTGCCTGTGGGTGAGTGCCAG
GGGCCTGCTGGGTGGTGGCCATCTGCGACCCGGCAGGGGGCTGTGCAGATTCTGCACCTGGCCATTCCCTGTCCTGTCTCCTCAGCCTGC
CTCACAGTGGCCATGGGGTGTCGGGGTGAAGGGCTGTCCCAGCTACTTGTCCTCTGCAGGACCCTAAGCCCCTGCCCGCAGCCCACATGC

>59818_59818_1_NOXO1-TPRN_NOXO1_chr16_2030940_ENST00000354249_TPRN_chr9_140087143_ENST00000321773_length(amino acids)=229AA_BP=3
MDRPELPSGSRELSGLTLLTNVARGRKSAKGFSSEPDPSSSSSSSSSSSSSSSCWSTSSSCSRELSEGYSNVVCRLLSLKEIFILSCLNS
SQLLRTKVSLPSDQRTEKANVWSLLICTRAAPCTETGYRGPAMAVASRLQIPEMGEDPSASPCLRGLWGTQKTPWDRILATPQACGVLVE

--------------------------------------------------------------
>59818_59818_2_NOXO1-TPRN_NOXO1_chr16_2030940_ENST00000354249_TPRN_chr9_140087143_ENST00000409012_length(transcript)=1423nt_BP=517nt
CTTCTCCTCCCTCCTCCTGTGGCCAGAGGCAGGCAGGAGGGCCCCAGGCAGCAGTCCCGCCTACCCTTCGCCCCTTCTTCAGTCTTGCAC
GCCTCCAGGGCTGGAAAGCTCATTCTTCTTCTTCCTCCCAGCAGCTCTGCCTGGAAGTCCCCCAATCCCTGTGCTCCTGCCCCCAGATCG
TGGGCTTGGGGGACAGCAAGAAAGCTGCAAAGGACTCAGCTGGGGCGGCTCCACAAGGACCCCACAGGCTTGAGGTGTTGCCAGGATTCT
ATCCCAGGGGGTTTTCTGGGTCCCCCAGAGCCCTCTCAAGCACGGGGAGGCAGAAGGGTCCTCGCCCATTTCAGGAATCTGCAGCCTGGA
AGCCACAGCCATGGCAGGCCCCCGATACCCAGTTTCAGTGCAAGGGGCAGCCCTGGTGCAGATCAAGAGGCTCCAAACGTTTGCCTTCTC
TGTGCGCTGGTCAGACGGCAGCGACACCTTCGTGCGCAGGAGTTGGGACGAATTCAGGCAGCTCAAGATGAAGATCTCCTTCAACGACAA
AAGCCTGCAGACCACATTTGAGTACCCTTCCGAGAGCTCCCTAGAGCAGGAGGAAGAGGTGGACCAGCAGGAGGAGGAGGAGGAGGAGGA
GGAGGAAGAGGAAGAGGAGGAAGAGGGATCCGGCTCAGAGGAGAAGCCCTTTGCACTCTTCCTGCCCCGGGCCACGTTTGTGAGCAGCGT
GAGACCCGAGAGCTCTCGGCTGCCAGAGGGTAGCTCAGGCCTGTCCAGCTACACCCCGAAGCACTCTGTGGCCTTCAGCAAGTGGCAGGA
GCAGGCGCTGGAGCAGGCCCCGAGGGAGGCAGAGCCCCCGCCCGTGGAGGCCATGCTCACACCCGCCAGTCAGAATGACCTCTCGGACTT
CCGCAGCGAGCCAGCCCTGTATTTCTGAGCCCAGCACTGCCAGGACCAAGGCTGAGCCCAGCTGTGGGAGTCCCGGAAGCTGGGCAGTAG
CCAGGGACTACTGCACCCGCTTCTGCCTTGTTTGGCCTCACTGTATCCCACCCACCCCTCCTGGCCCTGGAAGCAGCTAGGGTGCCTCCT
GCCATCGGGGCCAGGTCTGGGTCTCACTCCCCGGCCCTGATTTGGGAGGGTCCAAGGGGGAAGTGGGGTGGGGAACTGCCTGTGGGTGAG
TGCCAGGGGCCTGCTGGGTGGTGGCCATCTGCGACCCGGCAGGGGGCTGTGCAGATTCTGCACCTGGCCATTCCCTGTCCTGTCTCCTCA
GCCTGCCTCACAGTGGCCATGGGGTGTCGGGGTGAAGGGCTGTCCCAGCTACTTGTCCTCTGCAGGACCCTAAGCCCCTGCCCGCAGCCC

>59818_59818_2_NOXO1-TPRN_NOXO1_chr16_2030940_ENST00000354249_TPRN_chr9_140087143_ENST00000409012_length(amino acids)=229AA_BP=3
MDRPELPSGSRELSGLTLLTNVARGRKSAKGFSSEPDPSSSSSSSSSSSSSSSCWSTSSSCSRELSEGYSNVVCRLLSLKEIFILSCLNS
SQLLRTKVSLPSDQRTEKANVWSLLICTRAAPCTETGYRGPAMAVASRLQIPEMGEDPSASPCLRGLWGTQKTPWDRILATPQACGVLVE

--------------------------------------------------------------
>59818_59818_3_NOXO1-TPRN_NOXO1_chr16_2030940_ENST00000356120_TPRN_chr9_140087143_ENST00000321773_length(transcript)=1425nt_BP=435nt
TCTTGCACGCCTCCAGGGCTGGAAAGCTCATTCTTCTTCTTCCTCCCAGCAGCTCTGCCTGGAAGTCCCCCAATCCCTGTGCTCCTGCCC
CCAGATCGTGGGCTTGGGGGACAGCAAGAAAGCTGCAAAGGACTCAGCTGGGGCGGCTCCACAAGGACCCCACAGGCTTGAGGTGTTGCC
AGGATTCTATCCCAGGGGGTTTTCTGGGTCCCCCAGAGCCCTCTCAAGCACGGGGAGGCAGAAGGGTCCTCGCCCATTTCAGGAATCTGC
AGCCTGGAAGCCACAGCCATGGCAGGCCCCCGATACCCAGTTTCAGTGCAAGGGGCAGCCCTGGTGCAGATCAAGAGGCTCCAAACGTTT
GCCTTCTCTGTGCGCTGGTCAGACGGCAGCGACACCTTCGTGCGCAGGAGTTGGGACGAATTCAGGCAGCTCAAGATGAAGATCTCCTTC
AACGACAAAAGCCTGCAGACCACATTTGAGTACCCTTCCGAGAGCTCCCTAGAGCAGGAGGAAGAGGTGGACCAGCAGGAGGAGGAGGAG
GAGGAGGAGGAGGAAGAGGAAGAGGAGGAAGAGGGATCCGGCTCAGAGGAGAAGCCCTTTGCACTCTTCCTGCCCCGGGCCACGTTTGTG
AGCAGCGTGAGACCCGAGAGCTCTCGGCTGCCAGAGGGTAGCTCAGGCCTGTCCAGCTACACCCCGAAGCACTCTGTGGCCTTCAGCAAG
TGGCAGGAGCAGGCGCTGGAGCAGGCCCCGAGGGAGGCAGAGCCCCCGCCCGTGGAGGCCATGGTGAGATGCGGGGGAGTGGAGCGCTGG
GGGGAGTCTGACACCCGGGCGAGCCCATGTGTCCACATTCTGTCCTCTCACTTTCAGCTCACACCCGCCAGTCAGAATGACCTCTCGGAC
TTCCGCAGCGAGCCAGCCCTGTATTTCTGAGCCCAGCACTGCCAGGACCAAGGCTGAGCCCAGCTGTGGGAGTCCCGGAAGCTGGGCAGT
AGCCAGGGACTACTGCACCCGCTTCTGCCTTGTTTGGCCTCACTGTATCCCACCCACCCCTCCTGGCCCTGGAAGCAGCTAGGGTGCCTC
CTGCCATCGGGGCCAGGTCTGGGTCTCACTCCCCGGCCCTGATTTGGGAGGGTCCAAGGGGGAAGTGGGGTGGGGAACTGCCTGTGGGTG
AGTGCCAGGGGCCTGCTGGGTGGTGGCCATCTGCGACCCGGCAGGGGGCTGTGCAGATTCTGCACCTGGCCATTCCCTGTCCTGTCTCCT
CAGCCTGCCTCACAGTGGCCATGGGGTGTCGGGGTGAAGGGCTGTCCCAGCTACTTGTCCTCTGCAGGACCCTAAGCCCCTGCCCGCAGC

>59818_59818_3_NOXO1-TPRN_NOXO1_chr16_2030940_ENST00000356120_TPRN_chr9_140087143_ENST00000321773_length(amino acids)=228AA_BP=3
MDRPELPSGSRELSGLTLLTNVARGRKSAKGFSSEPDPSSSSSSSSSSSSSSSCWSTSSSCSRELSEGYSNVVCRLLSLKEIFILSCLNS
SQLLRTKVSLPSDQRTEKANVWSLLICTRAAPCTETGYRGPAMAVASRLQIPEMGEDPSASPCLRGLWGTQKTPWDRILATPQACGVLVE

--------------------------------------------------------------
>59818_59818_4_NOXO1-TPRN_NOXO1_chr16_2030940_ENST00000356120_TPRN_chr9_140087143_ENST00000409012_length(transcript)=1341nt_BP=435nt
TCTTGCACGCCTCCAGGGCTGGAAAGCTCATTCTTCTTCTTCCTCCCAGCAGCTCTGCCTGGAAGTCCCCCAATCCCTGTGCTCCTGCCC
CCAGATCGTGGGCTTGGGGGACAGCAAGAAAGCTGCAAAGGACTCAGCTGGGGCGGCTCCACAAGGACCCCACAGGCTTGAGGTGTTGCC
AGGATTCTATCCCAGGGGGTTTTCTGGGTCCCCCAGAGCCCTCTCAAGCACGGGGAGGCAGAAGGGTCCTCGCCCATTTCAGGAATCTGC
AGCCTGGAAGCCACAGCCATGGCAGGCCCCCGATACCCAGTTTCAGTGCAAGGGGCAGCCCTGGTGCAGATCAAGAGGCTCCAAACGTTT
GCCTTCTCTGTGCGCTGGTCAGACGGCAGCGACACCTTCGTGCGCAGGAGTTGGGACGAATTCAGGCAGCTCAAGATGAAGATCTCCTTC
AACGACAAAAGCCTGCAGACCACATTTGAGTACCCTTCCGAGAGCTCCCTAGAGCAGGAGGAAGAGGTGGACCAGCAGGAGGAGGAGGAG
GAGGAGGAGGAGGAAGAGGAAGAGGAGGAAGAGGGATCCGGCTCAGAGGAGAAGCCCTTTGCACTCTTCCTGCCCCGGGCCACGTTTGTG
AGCAGCGTGAGACCCGAGAGCTCTCGGCTGCCAGAGGGTAGCTCAGGCCTGTCCAGCTACACCCCGAAGCACTCTGTGGCCTTCAGCAAG
TGGCAGGAGCAGGCGCTGGAGCAGGCCCCGAGGGAGGCAGAGCCCCCGCCCGTGGAGGCCATGCTCACACCCGCCAGTCAGAATGACCTC
TCGGACTTCCGCAGCGAGCCAGCCCTGTATTTCTGAGCCCAGCACTGCCAGGACCAAGGCTGAGCCCAGCTGTGGGAGTCCCGGAAGCTG
GGCAGTAGCCAGGGACTACTGCACCCGCTTCTGCCTTGTTTGGCCTCACTGTATCCCACCCACCCCTCCTGGCCCTGGAAGCAGCTAGGG
TGCCTCCTGCCATCGGGGCCAGGTCTGGGTCTCACTCCCCGGCCCTGATTTGGGAGGGTCCAAGGGGGAAGTGGGGTGGGGAACTGCCTG
TGGGTGAGTGCCAGGGGCCTGCTGGGTGGTGGCCATCTGCGACCCGGCAGGGGGCTGTGCAGATTCTGCACCTGGCCATTCCCTGTCCTG
TCTCCTCAGCCTGCCTCACAGTGGCCATGGGGTGTCGGGGTGAAGGGCTGTCCCAGCTACTTGTCCTCTGCAGGACCCTAAGCCCCTGCC

>59818_59818_4_NOXO1-TPRN_NOXO1_chr16_2030940_ENST00000356120_TPRN_chr9_140087143_ENST00000409012_length(amino acids)=228AA_BP=3
MDRPELPSGSRELSGLTLLTNVARGRKSAKGFSSEPDPSSSSSSSSSSSSSSSCWSTSSSCSRELSEGYSNVVCRLLSLKEIFILSCLNS
SQLLRTKVSLPSDQRTEKANVWSLLICTRAAPCTETGYRGPAMAVASRLQIPEMGEDPSASPCLRGLWGTQKTPWDRILATPQACGVLVE

--------------------------------------------------------------
>59818_59818_5_NOXO1-TPRN_NOXO1_chr16_2030940_ENST00000397280_TPRN_chr9_140087143_ENST00000321773_length(transcript)=1141nt_BP=151nt
AGCCATGGCAGGCCCCCGATACCCAGTTTCAGTGCAAGGGGCAGCCCTGGTGCAGATCAAGAGGCTCCAAACGTTTGCCTTCTCTGTGCG
CTGGTCAGACGGCAGCGACACCTTCGTGCGCAGGAGTTGGGACGAATTCAGGCAGCTCAAGATGAAGATCTCCTTCAACGACAAAAGCCT
GCAGACCACATTTGAGTACCCTTCCGAGAGCTCCCTAGAGCAGGAGGAAGAGGTGGACCAGCAGGAGGAGGAGGAGGAGGAGGAGGAGGA
AGAGGAAGAGGAGGAAGAGGGATCCGGCTCAGAGGAGAAGCCCTTTGCACTCTTCCTGCCCCGGGCCACGTTTGTGAGCAGCGTGAGACC
CGAGAGCTCTCGGCTGCCAGAGGGTAGCTCAGGCCTGTCCAGCTACACCCCGAAGCACTCTGTGGCCTTCAGCAAGTGGCAGGAGCAGGC
GCTGGAGCAGGCCCCGAGGGAGGCAGAGCCCCCGCCCGTGGAGGCCATGGTGAGATGCGGGGGAGTGGAGCGCTGGGGGGAGTCTGACAC
CCGGGCGAGCCCATGTGTCCACATTCTGTCCTCTCACTTTCAGCTCACACCCGCCAGTCAGAATGACCTCTCGGACTTCCGCAGCGAGCC
AGCCCTGTATTTCTGAGCCCAGCACTGCCAGGACCAAGGCTGAGCCCAGCTGTGGGAGTCCCGGAAGCTGGGCAGTAGCCAGGGACTACT
GCACCCGCTTCTGCCTTGTTTGGCCTCACTGTATCCCACCCACCCCTCCTGGCCCTGGAAGCAGCTAGGGTGCCTCCTGCCATCGGGGCC
AGGTCTGGGTCTCACTCCCCGGCCCTGATTTGGGAGGGTCCAAGGGGGAAGTGGGGTGGGGAACTGCCTGTGGGTGAGTGCCAGGGGCCT
GCTGGGTGGTGGCCATCTGCGACCCGGCAGGGGGCTGTGCAGATTCTGCACCTGGCCATTCCCTGTCCTGTCTCCTCAGCCTGCCTCACA
GTGGCCATGGGGTGTCGGGGTGAAGGGCTGTCCCAGCTACTTGTCCTCTGCAGGACCCTAAGCCCCTGCCCGCAGCCCACATGCCCTCTG

>59818_59818_5_NOXO1-TPRN_NOXO1_chr16_2030940_ENST00000397280_TPRN_chr9_140087143_ENST00000321773_length(amino acids)=213AA_BP=49
MAGPRYPVSVQGAALVQIKRLQTFAFSVRWSDGSDTFVRRSWDEFRQLKMKISFNDKSLQTTFEYPSESSLEQEEEVDQQEEEEEEEEEE
EEEEEGSGSEEKPFALFLPRATFVSSVRPESSRLPEGSSGLSSYTPKHSVAFSKWQEQALEQAPREAEPPPVEAMVRCGGVERWGESDTR

--------------------------------------------------------------
>59818_59818_6_NOXO1-TPRN_NOXO1_chr16_2030940_ENST00000397280_TPRN_chr9_140087143_ENST00000409012_length(transcript)=1057nt_BP=151nt
AGCCATGGCAGGCCCCCGATACCCAGTTTCAGTGCAAGGGGCAGCCCTGGTGCAGATCAAGAGGCTCCAAACGTTTGCCTTCTCTGTGCG
CTGGTCAGACGGCAGCGACACCTTCGTGCGCAGGAGTTGGGACGAATTCAGGCAGCTCAAGATGAAGATCTCCTTCAACGACAAAAGCCT
GCAGACCACATTTGAGTACCCTTCCGAGAGCTCCCTAGAGCAGGAGGAAGAGGTGGACCAGCAGGAGGAGGAGGAGGAGGAGGAGGAGGA
AGAGGAAGAGGAGGAAGAGGGATCCGGCTCAGAGGAGAAGCCCTTTGCACTCTTCCTGCCCCGGGCCACGTTTGTGAGCAGCGTGAGACC
CGAGAGCTCTCGGCTGCCAGAGGGTAGCTCAGGCCTGTCCAGCTACACCCCGAAGCACTCTGTGGCCTTCAGCAAGTGGCAGGAGCAGGC
GCTGGAGCAGGCCCCGAGGGAGGCAGAGCCCCCGCCCGTGGAGGCCATGCTCACACCCGCCAGTCAGAATGACCTCTCGGACTTCCGCAG
CGAGCCAGCCCTGTATTTCTGAGCCCAGCACTGCCAGGACCAAGGCTGAGCCCAGCTGTGGGAGTCCCGGAAGCTGGGCAGTAGCCAGGG
ACTACTGCACCCGCTTCTGCCTTGTTTGGCCTCACTGTATCCCACCCACCCCTCCTGGCCCTGGAAGCAGCTAGGGTGCCTCCTGCCATC
GGGGCCAGGTCTGGGTCTCACTCCCCGGCCCTGATTTGGGAGGGTCCAAGGGGGAAGTGGGGTGGGGAACTGCCTGTGGGTGAGTGCCAG
GGGCCTGCTGGGTGGTGGCCATCTGCGACCCGGCAGGGGGCTGTGCAGATTCTGCACCTGGCCATTCCCTGTCCTGTCTCCTCAGCCTGC
CTCACAGTGGCCATGGGGTGTCGGGGTGAAGGGCTGTCCCAGCTACTTGTCCTCTGCAGGACCCTAAGCCCCTGCCCGCAGCCCACATGC

>59818_59818_6_NOXO1-TPRN_NOXO1_chr16_2030940_ENST00000397280_TPRN_chr9_140087143_ENST00000409012_length(amino acids)=185AA_BP=49
MAGPRYPVSVQGAALVQIKRLQTFAFSVRWSDGSDTFVRRSWDEFRQLKMKISFNDKSLQTTFEYPSESSLEQEEEVDQQEEEEEEEEEE
EEEEEGSGSEEKPFALFLPRATFVSSVRPESSRLPEGSSGLSSYTPKHSVAFSKWQEQALEQAPREAEPPPVEAMLTPASQNDLSDFRSE

--------------------------------------------------------------
>59818_59818_7_NOXO1-TPRN_NOXO1_chr16_2030940_ENST00000566005_TPRN_chr9_140087143_ENST00000321773_length(transcript)=1141nt_BP=151nt
AGCCATGGCAGGCCCCCGATACCCAGTTTCAGTGCAAGGGGCAGCCCTGGTGCAGATCAAGAGGCTCCAAACGTTTGCCTTCTCTGTGCG
CTGGTCAGACGGCAGCGACACCTTCGTGCGCAGGAGTTGGGACGAATTCAGGCAGCTCAAGATGAAGATCTCCTTCAACGACAAAAGCCT
GCAGACCACATTTGAGTACCCTTCCGAGAGCTCCCTAGAGCAGGAGGAAGAGGTGGACCAGCAGGAGGAGGAGGAGGAGGAGGAGGAGGA
AGAGGAAGAGGAGGAAGAGGGATCCGGCTCAGAGGAGAAGCCCTTTGCACTCTTCCTGCCCCGGGCCACGTTTGTGAGCAGCGTGAGACC
CGAGAGCTCTCGGCTGCCAGAGGGTAGCTCAGGCCTGTCCAGCTACACCCCGAAGCACTCTGTGGCCTTCAGCAAGTGGCAGGAGCAGGC
GCTGGAGCAGGCCCCGAGGGAGGCAGAGCCCCCGCCCGTGGAGGCCATGGTGAGATGCGGGGGAGTGGAGCGCTGGGGGGAGTCTGACAC
CCGGGCGAGCCCATGTGTCCACATTCTGTCCTCTCACTTTCAGCTCACACCCGCCAGTCAGAATGACCTCTCGGACTTCCGCAGCGAGCC
AGCCCTGTATTTCTGAGCCCAGCACTGCCAGGACCAAGGCTGAGCCCAGCTGTGGGAGTCCCGGAAGCTGGGCAGTAGCCAGGGACTACT
GCACCCGCTTCTGCCTTGTTTGGCCTCACTGTATCCCACCCACCCCTCCTGGCCCTGGAAGCAGCTAGGGTGCCTCCTGCCATCGGGGCC
AGGTCTGGGTCTCACTCCCCGGCCCTGATTTGGGAGGGTCCAAGGGGGAAGTGGGGTGGGGAACTGCCTGTGGGTGAGTGCCAGGGGCCT
GCTGGGTGGTGGCCATCTGCGACCCGGCAGGGGGCTGTGCAGATTCTGCACCTGGCCATTCCCTGTCCTGTCTCCTCAGCCTGCCTCACA
GTGGCCATGGGGTGTCGGGGTGAAGGGCTGTCCCAGCTACTTGTCCTCTGCAGGACCCTAAGCCCCTGCCCGCAGCCCACATGCCCTCTG

>59818_59818_7_NOXO1-TPRN_NOXO1_chr16_2030940_ENST00000566005_TPRN_chr9_140087143_ENST00000321773_length(amino acids)=213AA_BP=49
MAGPRYPVSVQGAALVQIKRLQTFAFSVRWSDGSDTFVRRSWDEFRQLKMKISFNDKSLQTTFEYPSESSLEQEEEVDQQEEEEEEEEEE
EEEEEGSGSEEKPFALFLPRATFVSSVRPESSRLPEGSSGLSSYTPKHSVAFSKWQEQALEQAPREAEPPPVEAMVRCGGVERWGESDTR

--------------------------------------------------------------
>59818_59818_8_NOXO1-TPRN_NOXO1_chr16_2030940_ENST00000566005_TPRN_chr9_140087143_ENST00000409012_length(transcript)=1057nt_BP=151nt
AGCCATGGCAGGCCCCCGATACCCAGTTTCAGTGCAAGGGGCAGCCCTGGTGCAGATCAAGAGGCTCCAAACGTTTGCCTTCTCTGTGCG
CTGGTCAGACGGCAGCGACACCTTCGTGCGCAGGAGTTGGGACGAATTCAGGCAGCTCAAGATGAAGATCTCCTTCAACGACAAAAGCCT
GCAGACCACATTTGAGTACCCTTCCGAGAGCTCCCTAGAGCAGGAGGAAGAGGTGGACCAGCAGGAGGAGGAGGAGGAGGAGGAGGAGGA
AGAGGAAGAGGAGGAAGAGGGATCCGGCTCAGAGGAGAAGCCCTTTGCACTCTTCCTGCCCCGGGCCACGTTTGTGAGCAGCGTGAGACC
CGAGAGCTCTCGGCTGCCAGAGGGTAGCTCAGGCCTGTCCAGCTACACCCCGAAGCACTCTGTGGCCTTCAGCAAGTGGCAGGAGCAGGC
GCTGGAGCAGGCCCCGAGGGAGGCAGAGCCCCCGCCCGTGGAGGCCATGCTCACACCCGCCAGTCAGAATGACCTCTCGGACTTCCGCAG
CGAGCCAGCCCTGTATTTCTGAGCCCAGCACTGCCAGGACCAAGGCTGAGCCCAGCTGTGGGAGTCCCGGAAGCTGGGCAGTAGCCAGGG
ACTACTGCACCCGCTTCTGCCTTGTTTGGCCTCACTGTATCCCACCCACCCCTCCTGGCCCTGGAAGCAGCTAGGGTGCCTCCTGCCATC
GGGGCCAGGTCTGGGTCTCACTCCCCGGCCCTGATTTGGGAGGGTCCAAGGGGGAAGTGGGGTGGGGAACTGCCTGTGGGTGAGTGCCAG
GGGCCTGCTGGGTGGTGGCCATCTGCGACCCGGCAGGGGGCTGTGCAGATTCTGCACCTGGCCATTCCCTGTCCTGTCTCCTCAGCCTGC
CTCACAGTGGCCATGGGGTGTCGGGGTGAAGGGCTGTCCCAGCTACTTGTCCTCTGCAGGACCCTAAGCCCCTGCCCGCAGCCCACATGC

>59818_59818_8_NOXO1-TPRN_NOXO1_chr16_2030940_ENST00000566005_TPRN_chr9_140087143_ENST00000409012_length(amino acids)=185AA_BP=49
MAGPRYPVSVQGAALVQIKRLQTFAFSVRWSDGSDTFVRRSWDEFRQLKMKISFNDKSLQTTFEYPSESSLEQEEEVDQQEEEEEEEEEE
EEEEEGSGSEEKPFALFLPRATFVSSVRPESSRLPEGSSGLSSYTPKHSVAFSKWQEQALEQAPREAEPPPVEAMLTPASQNDLSDFRSE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NOXO1-TPRN

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for NOXO1-TPRN

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for NOXO1-TPRN

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source