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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NPEPPS-CREB3L1 (FusionGDB2 ID:59877)

Fusion Gene Summary for NPEPPS-CREB3L1

Fusion gene summary

Fusion gene information	Fusion gene name: NPEPPS-CREB3L1
	Fusion gene ID: 59877
		Hgene	Tgene
	Gene symbol	NPEPPS	CREB3L1
	Gene ID	9520	90993
	Gene name	aminopeptidase puromycin sensitive	cAMP responsive element binding protein 3 like 1
	Synonyms	AAP-S\|MP100\|PSA	OASIS\|OI16
	Cytomap	17q21.32	11p11.2
	Type of gene	protein-coding	protein-coding
	Description	puromycin-sensitive aminopeptidasecytosol alanyl aminopeptidasemetalloproteinase MP100	cyclic AMP-responsive element-binding protein 3-like protein 1BBF-2 homologcAMP-responsive element-binding protein 3-like protein 1old astrocyte specifically-induced substance
	Modification date	20200313	20200327
	UniProtAcc	P55786	Q96BA8
	Ensembl transtripts involved in fusion gene	ENST00000525037, ENST00000322157, ENST00000530173, ENST00000544660,	ENST00000288400, ENST00000529193, ENST00000534616,
Fusion gene scores	* DoF score	18 X 9 X 9=1458	10 X 10 X 4=400
	# samples	19	8
	** MAII score	log2(19/1458*10)=-2.93991939599599 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/400*10)=-2.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NPEPPS [Title/Abstract] AND CREB3L1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NPEPPS(45623359)-CREB3L1(46341815), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NPEPPS	GO:0071456	cellular response to hypoxia	21056661
Tgene	CREB3L1	GO:0010629	negative regulation of gene expression	27121396
Tgene	CREB3L1	GO:0032967	positive regulation of collagen biosynthetic process	25310401
Tgene	CREB3L1	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	27121396
Tgene	CREB3L1	GO:0045892	negative regulation of transcription, DNA-templated	27121396

Fusion gene breakpoints across NPEPPS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CREB3L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCS	TCGA-NA-A5I1-01A	NPEPPS	chr17	45623359	+	CREB3L1	chr11	46341815	+
ChimerDB4	UCS	TCGA-NA-A5I1	NPEPPS	chr17	45623359	+	CREB3L1	chr11	46341815	+

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Fusion Gene ORF analysis for NPEPPS-CREB3L1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000525037	ENST00000288400	NPEPPS	chr17	45623359	+	CREB3L1	chr11	46341815	+
3UTR-3CDS	ENST00000525037	ENST00000529193	NPEPPS	chr17	45623359	+	CREB3L1	chr11	46341815	+
3UTR-3UTR	ENST00000525037	ENST00000534616	NPEPPS	chr17	45623359	+	CREB3L1	chr11	46341815	+
5CDS-3UTR	ENST00000322157	ENST00000534616	NPEPPS	chr17	45623359	+	CREB3L1	chr11	46341815	+
5CDS-3UTR	ENST00000530173	ENST00000534616	NPEPPS	chr17	45623359	+	CREB3L1	chr11	46341815	+
5CDS-3UTR	ENST00000544660	ENST00000534616	NPEPPS	chr17	45623359	+	CREB3L1	chr11	46341815	+
In-frame	ENST00000322157	ENST00000288400	NPEPPS	chr17	45623359	+	CREB3L1	chr11	46341815	+
In-frame	ENST00000322157	ENST00000529193	NPEPPS	chr17	45623359	+	CREB3L1	chr11	46341815	+
In-frame	ENST00000530173	ENST00000288400	NPEPPS	chr17	45623359	+	CREB3L1	chr11	46341815	+
In-frame	ENST00000530173	ENST00000529193	NPEPPS	chr17	45623359	+	CREB3L1	chr11	46341815	+
In-frame	ENST00000544660	ENST00000288400	NPEPPS	chr17	45623359	+	CREB3L1	chr11	46341815	+
In-frame	ENST00000544660	ENST00000529193	NPEPPS	chr17	45623359	+	CREB3L1	chr11	46341815	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000530173	NPEPPS	chr17	45623359	+	ENST00000529193	CREB3L1	chr11	46341815	+	1336	358	30	659	209
ENST00000530173	NPEPPS	chr17	45623359	+	ENST00000288400	CREB3L1	chr11	46341815	+	1334	358	30	659	209
ENST00000322157	NPEPPS	chr17	45623359	+	ENST00000529193	CREB3L1	chr11	46341815	+	1555	577	66	878	270
ENST00000322157	NPEPPS	chr17	45623359	+	ENST00000288400	CREB3L1	chr11	46341815	+	1553	577	66	878	270
ENST00000544660	NPEPPS	chr17	45623359	+	ENST00000529193	CREB3L1	chr11	46341815	+	1292	314	13	615	200
ENST00000544660	NPEPPS	chr17	45623359	+	ENST00000288400	CREB3L1	chr11	46341815	+	1290	314	13	615	200

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000530173	ENST00000529193	NPEPPS	chr17	45623359	+	CREB3L1	chr11	46341815	+	0.025895497	0.97410446
ENST00000530173	ENST00000288400	NPEPPS	chr17	45623359	+	CREB3L1	chr11	46341815	+	0.026064781	0.9739352
ENST00000322157	ENST00000529193	NPEPPS	chr17	45623359	+	CREB3L1	chr11	46341815	+	0.044976186	0.95502377
ENST00000322157	ENST00000288400	NPEPPS	chr17	45623359	+	CREB3L1	chr11	46341815	+	0.046533797	0.9534662
ENST00000544660	ENST00000529193	NPEPPS	chr17	45623359	+	CREB3L1	chr11	46341815	+	0.009365995	0.9906341
ENST00000544660	ENST00000288400	NPEPPS	chr17	45623359	+	CREB3L1	chr11	46341815	+	0.009596954	0.99040306

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Fusion Genomic Features for NPEPPS-CREB3L1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
NPEPPS	chr17	45623359	+	CREB3L1	chr11	46341814	+	2.60E-08	1
NPEPPS	chr17	45623359	+	CREB3L1	chr11	46341814	+	2.60E-08	1
NPEPPS	chr17	45623359	+	CREB3L1	chr11	46341814	+	2.60E-08	1
NPEPPS	chr17	45623359	+	CREB3L1	chr11	46341814	+	2.60E-08	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NPEPPS-CREB3L1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:45623359/chr11:46341815)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NPEPPS P55786	CREB3L1 Q96BA8
FUNCTION: Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. {ECO:0000269\|PubMed:10978616, ECO:0000269\|PubMed:11062501, ECO:0000269\|PubMed:17154549, ECO:0000269\|PubMed:17318184, ECO:0000269\|PubMed:19917696}.	FUNCTION: Transcription factor involved in unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (PubMed:21767813). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (By similarity). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation (By similarity). Required for TGFB1 to activate genes involved in the assembly of collagen extracellular matrix (PubMed:25310401). {ECO:0000250\|UniProtKB:Q9Z125, ECO:0000269\|PubMed:12054625, ECO:0000269\|PubMed:21767813, ECO:0000269\|PubMed:25310401}.; FUNCTION: (Microbial infection) May play a role in limiting virus spread by inhibiting proliferation of virus-infected cells. Upon infection with diverse DNA and RNA viruses, inhibits cell-cycle progression by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A (PubMed:21767813). {ECO:0000269\|PubMed:21767813}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CREB3L1

chr17:45623359

chr11:46341815

ENST00000288400

423_426

419

520.0

Motif

S1P recognition

Tgene

CREB3L1

chr17:45623359

chr11:46341815

ENST00000529193

423_426

419

520.0

Motif

S1P recognition

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NPEPPS

chr17:45623359

chr11:46341815

ENST00000322157

726_730

113

920.0

Motif

Nuclear localization signal

Hgene

NPEPPS

chr17:45623359

chr11:46341815

ENST00000322157

316_320

113

920.0

Region

Substrate binding

Tgene

CREB3L1

chr17:45623359

chr11:46341815

ENST00000288400

146_154

419

520.0

Compositional bias

Note=Poly-Ala

Tgene

CREB3L1

chr17:45623359

chr11:46341815

ENST00000529193

146_154

419

520.0

Compositional bias

Note=Poly-Ala

Tgene

CREB3L1

chr17:45623359

chr11:46341815

ENST00000288400

290_353

419

520.0

Domain

bZIP

Tgene

CREB3L1

chr17:45623359

chr11:46341815

ENST00000529193

290_353

419

520.0

Domain

bZIP

Tgene

CREB3L1

chr17:45623359

chr11:46341815

ENST00000288400

392_395

419

520.0

Motif

S2P recognition

Tgene

CREB3L1

chr17:45623359

chr11:46341815

ENST00000529193

392_395

419

520.0

Motif

S2P recognition

Tgene

CREB3L1

chr17:45623359

chr11:46341815

ENST00000288400

1_60

419

520.0

Region

Note=Required for transcriptional activation

Tgene

CREB3L1

chr17:45623359

chr11:46341815

ENST00000288400

292_321

419

520.0

Region

Basic motif

Tgene

CREB3L1

chr17:45623359

chr11:46341815

ENST00000288400

332_353

419

520.0

Region

Leucine-zipper

Tgene

CREB3L1

chr17:45623359

chr11:46341815

ENST00000529193

1_60

419

520.0

Region

Note=Required for transcriptional activation

Tgene

CREB3L1

chr17:45623359

chr11:46341815

ENST00000529193

292_321

419

520.0

Region

Basic motif

Tgene

CREB3L1

chr17:45623359

chr11:46341815

ENST00000529193

332_353

419

520.0

Region

Leucine-zipper

Tgene

CREB3L1

chr17:45623359

chr11:46341815

ENST00000288400

1_374

419

520.0

Topological domain

Cytoplasmic

Tgene

CREB3L1

chr17:45623359

chr11:46341815

ENST00000288400

396_519

419

520.0

Topological domain

Lumenal

Tgene

CREB3L1

chr17:45623359

chr11:46341815

ENST00000529193

1_374

419

520.0

Topological domain

Cytoplasmic

Tgene

CREB3L1

chr17:45623359

chr11:46341815

ENST00000529193

396_519

419

520.0

Topological domain

Lumenal

Tgene

CREB3L1

chr17:45623359

chr11:46341815

ENST00000288400

375_395

419

520.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

CREB3L1

chr17:45623359

chr11:46341815

ENST00000529193

375_395

419

520.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

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Fusion Gene Sequence for NPEPPS-CREB3L1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>59877_59877_1_NPEPPS-CREB3L1_NPEPPS_chr17_45623359_ENST00000322157_CREB3L1_chr11_46341815_ENST00000288400_length(transcript)=1553nt_BP=577nt
GGGCGCGCCCGGCCGGCGGGGCCGCGCACGCAGCCGCCGCCACCACTTCCCCCTCTCCCTCCCTCCTTGCGGGCCCTCCTCCCCTTCCCT
CCCCTCCGCCCCCTTCCCCGTAGGCAGCCCGCCCGCCAGTCCGCCCGCACCGCCTCCTTCCCAGCCCCTAGCGCTCCGGCTGGGTCTCTC
CCCCGCCCCCCAGGCTCCCCCGGTCGCTCTCCTCCGGCGGTCGCCCGCGCTCGGTGGATGTGGCTGGCAGCTGCCGCCCCCTCCCTCGCT
CGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGC
CTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTG
CTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATTGAT
ATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGTGCCCTCCCGAAGCCTCCTATTCTACGATGACGGGGCAGGCTTATGGGAAGAT
GGCCGCAGCACCCTGCTGCCCATGGAGCCCCCAGATGGCTGGGAAATCAACCCCGGGGGGCCGGCAGAGCAGCGGCCCCGGGACCACCTG
CAGCATGATCACCTGGACAGCACCCACGAGACCACCAAGTACCTGAGTGAGGCCTGGCCTAAAGACGGTGGAAACGGCACCAGCCCCGAC
TTCTCCCACTCCAAGGAGTGGTTCCACGACAGGGATCTGGGCCCCAACACCACCATCAAACTCTCCTAGGCCATGCCAAGACCCAGGACA
TAGGACGGACCCCTGGTACCCAGAAGAGGAGTTCTTGCTCACTAACCCGGATCCGCCTCGTGCCCCTGCCTCCTGGAGCTTCCCATTCCA
GGAGAAAAGGCTCCACTTCCCAGCCCTTCCTTGCCCCTGACATTTGGACTCTTCCCTTGGGCCGACCACTCTGTTCTCATTCTCCTTCCC
ACCAACATCCATCCGTCCTTCTCAGACAAACCACTCACTGGGTACCCCACCTCCTCTCTCATATGCCCAACACGACCACTGCCTCCCTGC
CCCCACACCTGCACCCAAACAGACACATCAACGCACCCCACTCACAGACACCCCTTACCCCACCCCCACTGTACAGAGACCAAGAACAGA
AATTGTTTGTAAATAATGAACCTTATTTTTTATTATTGCCAATCCCCTAAGATATTGTATTTTACAAATCTCCCTCTTCCCTTCGCCCCT
CCCTTGTTTTATATTTTATGAAGTTAGTGCGGGCTTTGCTGCTCCCTGGCCCAGGAAAGAGGGACTACCTGACCCTCACCTGGCACCCCC
CTGCTGCTGCCCAAGCCGCTGGGCCTTTTTAATTGCCAAACTGCTCTCTTCATCAGCTCAGCACATGCTTTAAGAAAGCAAAACCAAAAA

>59877_59877_1_NPEPPS-CREB3L1_NPEPPS_chr17_45623359_ENST00000322157_CREB3L1_chr11_46341815_ENST00000288400_length(amino acids)=270AA_BP=170
MRALLPFPPLRPLPRRQPARQSARTASFPAPSAPAGSLPRPPGSPGRSPPAVARARWMWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSS
RRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEVPSRSLLFYD
DGAGLWEDGRSTLLPMEPPDGWEINPGGPAEQRPRDHLQHDHLDSTHETTKYLSEAWPKDGGNGTSPDFSHSKEWFHDRDLGPNTTIKLS

--------------------------------------------------------------
>59877_59877_2_NPEPPS-CREB3L1_NPEPPS_chr17_45623359_ENST00000322157_CREB3L1_chr11_46341815_ENST00000529193_length(transcript)=1555nt_BP=577nt
GGGCGCGCCCGGCCGGCGGGGCCGCGCACGCAGCCGCCGCCACCACTTCCCCCTCTCCCTCCCTCCTTGCGGGCCCTCCTCCCCTTCCCT
CCCCTCCGCCCCCTTCCCCGTAGGCAGCCCGCCCGCCAGTCCGCCCGCACCGCCTCCTTCCCAGCCCCTAGCGCTCCGGCTGGGTCTCTC
CCCCGCCCCCCAGGCTCCCCCGGTCGCTCTCCTCCGGCGGTCGCCCGCGCTCGGTGGATGTGGCTGGCAGCTGCCGCCCCCTCCCTCGCT
CGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGC
CTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTG
CTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATTGAT
ATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGTGCCCTCCCGAAGCCTCCTATTCTACGATGACGGGGCAGGCTTATGGGAAGAT
GGCCGCAGCACCCTGCTGCCCATGGAGCCCCCAGATGGCTGGGAAATCAACCCCGGGGGGCCGGCAGAGCAGCGGCCCCGGGACCACCTG
CAGCATGATCACCTGGACAGCACCCACGAGACCACCAAGTACCTGAGTGAGGCCTGGCCTAAAGACGGTGGAAACGGCACCAGCCCCGAC
TTCTCCCACTCCAAGGAGTGGTTCCACGACAGGGATCTGGGCCCCAACACCACCATCAAACTCTCCTAGGCCATGCCAAGACCCAGGACA
TAGGACGGACCCCTGGTACCCAGAAGAGGAGTTCTTGCTCACTAACCCGGATCCGCCTCGTGCCCCTGCCTCCTGGAGCTTCCCATTCCA
GGAGAAAAGGCTCCACTTCCCAGCCCTTCCTTGCCCCTGACATTTGGACTCTTCCCTTGGGCCGACCACTCTGTTCTCATTCTCCTTCCC
ACCAACATCCATCCGTCCTTCTCAGACAAACCACTCACTGGGTACCCCACCTCCTCTCTCATATGCCCAACACGACCACTGCCTCCCTGC
CCCCACACCTGCACCCAAACAGACACATCAACGCACCCCACTCACAGACACCCCTTACCCCACCCCCACTGTACAGAGACCAAGAACAGA
AATTGTTTGTAAATAATGAACCTTATTTTTTATTATTGCCAATCCCCTAAGATATTGTATTTTACAAATCTCCCTCTTCCCTTCGCCCCT
CCCTTGTTTTATATTTTATGAAGTTAGTGCGGGCTTTGCTGCTCCCTGGCCCAGGAAAGAGGGACTACCTGACCCTCACCTGGCACCCCC
CTGCTGCTGCCCAAGCCGCTGGGCCTTTTTAATTGCCAAACTGCTCTCTTCATCAGCTCAGCACATGCTTTAAGAAAGCAAAACCAAAAA

>59877_59877_2_NPEPPS-CREB3L1_NPEPPS_chr17_45623359_ENST00000322157_CREB3L1_chr11_46341815_ENST00000529193_length(amino acids)=270AA_BP=170
MRALLPFPPLRPLPRRQPARQSARTASFPAPSAPAGSLPRPPGSPGRSPPAVARARWMWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSS
RRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEVPSRSLLFYD
DGAGLWEDGRSTLLPMEPPDGWEINPGGPAEQRPRDHLQHDHLDSTHETTKYLSEAWPKDGGNGTSPDFSHSKEWFHDRDLGPNTTIKLS

--------------------------------------------------------------
>59877_59877_3_NPEPPS-CREB3L1_NPEPPS_chr17_45623359_ENST00000530173_CREB3L1_chr11_46341815_ENST00000288400_length(transcript)=1334nt_BP=358nt
AAGTTACGGAAGAGTCAAGGCTGGGACCTCATGGCATCATTTTCCATGGATTGCTCTCCAAGTTTTTGTGTTCCTGGCCTTTGGAACCCC
TTCATCATATTCCGCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTG
CCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCC
CAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGTG
CCCTCCCGAAGCCTCCTATTCTACGATGACGGGGCAGGCTTATGGGAAGATGGCCGCAGCACCCTGCTGCCCATGGAGCCCCCAGATGGC
TGGGAAATCAACCCCGGGGGGCCGGCAGAGCAGCGGCCCCGGGACCACCTGCAGCATGATCACCTGGACAGCACCCACGAGACCACCAAG
TACCTGAGTGAGGCCTGGCCTAAAGACGGTGGAAACGGCACCAGCCCCGACTTCTCCCACTCCAAGGAGTGGTTCCACGACAGGGATCTG
GGCCCCAACACCACCATCAAACTCTCCTAGGCCATGCCAAGACCCAGGACATAGGACGGACCCCTGGTACCCAGAAGAGGAGTTCTTGCT
CACTAACCCGGATCCGCCTCGTGCCCCTGCCTCCTGGAGCTTCCCATTCCAGGAGAAAAGGCTCCACTTCCCAGCCCTTCCTTGCCCCTG
ACATTTGGACTCTTCCCTTGGGCCGACCACTCTGTTCTCATTCTCCTTCCCACCAACATCCATCCGTCCTTCTCAGACAAACCACTCACT
GGGTACCCCACCTCCTCTCTCATATGCCCAACACGACCACTGCCTCCCTGCCCCCACACCTGCACCCAAACAGACACATCAACGCACCCC
ACTCACAGACACCCCTTACCCCACCCCCACTGTACAGAGACCAAGAACAGAAATTGTTTGTAAATAATGAACCTTATTTTTTATTATTGC
CAATCCCCTAAGATATTGTATTTTACAAATCTCCCTCTTCCCTTCGCCCCTCCCTTGTTTTATATTTTATGAAGTTAGTGCGGGCTTTGC
TGCTCCCTGGCCCAGGAAAGAGGGACTACCTGACCCTCACCTGGCACCCCCCTGCTGCTGCCCAAGCCGCTGGGCCTTTTTAATTGCCAA

>59877_59877_3_NPEPPS-CREB3L1_NPEPPS_chr17_45623359_ENST00000530173_CREB3L1_chr11_46341815_ENST00000288400_length(amino acids)=209AA_BP=109
MASFSMDCSPSFCVPGLWNPFIIFRSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIV
MNCADIDIITASYAPEGDEVPSRSLLFYDDGAGLWEDGRSTLLPMEPPDGWEINPGGPAEQRPRDHLQHDHLDSTHETTKYLSEAWPKDG

--------------------------------------------------------------
>59877_59877_4_NPEPPS-CREB3L1_NPEPPS_chr17_45623359_ENST00000530173_CREB3L1_chr11_46341815_ENST00000529193_length(transcript)=1336nt_BP=358nt
AAGTTACGGAAGAGTCAAGGCTGGGACCTCATGGCATCATTTTCCATGGATTGCTCTCCAAGTTTTTGTGTTCCTGGCCTTTGGAACCCC
TTCATCATATTCCGCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTG
CCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCC
CAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGTG
CCCTCCCGAAGCCTCCTATTCTACGATGACGGGGCAGGCTTATGGGAAGATGGCCGCAGCACCCTGCTGCCCATGGAGCCCCCAGATGGC
TGGGAAATCAACCCCGGGGGGCCGGCAGAGCAGCGGCCCCGGGACCACCTGCAGCATGATCACCTGGACAGCACCCACGAGACCACCAAG
TACCTGAGTGAGGCCTGGCCTAAAGACGGTGGAAACGGCACCAGCCCCGACTTCTCCCACTCCAAGGAGTGGTTCCACGACAGGGATCTG
GGCCCCAACACCACCATCAAACTCTCCTAGGCCATGCCAAGACCCAGGACATAGGACGGACCCCTGGTACCCAGAAGAGGAGTTCTTGCT
CACTAACCCGGATCCGCCTCGTGCCCCTGCCTCCTGGAGCTTCCCATTCCAGGAGAAAAGGCTCCACTTCCCAGCCCTTCCTTGCCCCTG
ACATTTGGACTCTTCCCTTGGGCCGACCACTCTGTTCTCATTCTCCTTCCCACCAACATCCATCCGTCCTTCTCAGACAAACCACTCACT
GGGTACCCCACCTCCTCTCTCATATGCCCAACACGACCACTGCCTCCCTGCCCCCACACCTGCACCCAAACAGACACATCAACGCACCCC
ACTCACAGACACCCCTTACCCCACCCCCACTGTACAGAGACCAAGAACAGAAATTGTTTGTAAATAATGAACCTTATTTTTTATTATTGC
CAATCCCCTAAGATATTGTATTTTACAAATCTCCCTCTTCCCTTCGCCCCTCCCTTGTTTTATATTTTATGAAGTTAGTGCGGGCTTTGC
TGCTCCCTGGCCCAGGAAAGAGGGACTACCTGACCCTCACCTGGCACCCCCCTGCTGCTGCCCAAGCCGCTGGGCCTTTTTAATTGCCAA

>59877_59877_4_NPEPPS-CREB3L1_NPEPPS_chr17_45623359_ENST00000530173_CREB3L1_chr11_46341815_ENST00000529193_length(amino acids)=209AA_BP=109
MASFSMDCSPSFCVPGLWNPFIIFRSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIV
MNCADIDIITASYAPEGDEVPSRSLLFYDDGAGLWEDGRSTLLPMEPPDGWEINPGGPAEQRPRDHLQHDHLDSTHETTKYLSEAWPKDG

--------------------------------------------------------------
>59877_59877_5_NPEPPS-CREB3L1_NPEPPS_chr17_45623359_ENST00000544660_CREB3L1_chr11_46341815_ENST00000288400_length(transcript)=1290nt_BP=314nt
CCTCGCTCGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAG
CCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCC
CGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGA
TATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGTGCCCTCCCGAAGCCTCCTATTCTACGATGACGGGGCAGGCTTATG
GGAAGATGGCCGCAGCACCCTGCTGCCCATGGAGCCCCCAGATGGCTGGGAAATCAACCCCGGGGGGCCGGCAGAGCAGCGGCCCCGGGA
CCACCTGCAGCATGATCACCTGGACAGCACCCACGAGACCACCAAGTACCTGAGTGAGGCCTGGCCTAAAGACGGTGGAAACGGCACCAG
CCCCGACTTCTCCCACTCCAAGGAGTGGTTCCACGACAGGGATCTGGGCCCCAACACCACCATCAAACTCTCCTAGGCCATGCCAAGACC
CAGGACATAGGACGGACCCCTGGTACCCAGAAGAGGAGTTCTTGCTCACTAACCCGGATCCGCCTCGTGCCCCTGCCTCCTGGAGCTTCC
CATTCCAGGAGAAAAGGCTCCACTTCCCAGCCCTTCCTTGCCCCTGACATTTGGACTCTTCCCTTGGGCCGACCACTCTGTTCTCATTCT
CCTTCCCACCAACATCCATCCGTCCTTCTCAGACAAACCACTCACTGGGTACCCCACCTCCTCTCTCATATGCCCAACACGACCACTGCC
TCCCTGCCCCCACACCTGCACCCAAACAGACACATCAACGCACCCCACTCACAGACACCCCTTACCCCACCCCCACTGTACAGAGACCAA
GAACAGAAATTGTTTGTAAATAATGAACCTTATTTTTTATTATTGCCAATCCCCTAAGATATTGTATTTTACAAATCTCCCTCTTCCCTT
CGCCCCTCCCTTGTTTTATATTTTATGAAGTTAGTGCGGGCTTTGCTGCTCCCTGGCCCAGGAAAGAGGGACTACCTGACCCTCACCTGG
CACCCCCCTGCTGCTGCCCAAGCCGCTGGGCCTTTTTAATTGCCAAACTGCTCTCTTCATCAGCTCAGCACATGCTTTAAGAAAGCAAAA

>59877_59877_5_NPEPPS-CREB3L1_NPEPPS_chr17_45623359_ENST00000544660_CREB3L1_chr11_46341815_ENST00000288400_length(amino acids)=200AA_BP=100
MLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDII
TASYAPEGDEVPSRSLLFYDDGAGLWEDGRSTLLPMEPPDGWEINPGGPAEQRPRDHLQHDHLDSTHETTKYLSEAWPKDGGNGTSPDFS

--------------------------------------------------------------
>59877_59877_6_NPEPPS-CREB3L1_NPEPPS_chr17_45623359_ENST00000544660_CREB3L1_chr11_46341815_ENST00000529193_length(transcript)=1292nt_BP=314nt
CCTCGCTCGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAG
CCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCC
CGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGA
TATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGTGCCCTCCCGAAGCCTCCTATTCTACGATGACGGGGCAGGCTTATG
GGAAGATGGCCGCAGCACCCTGCTGCCCATGGAGCCCCCAGATGGCTGGGAAATCAACCCCGGGGGGCCGGCAGAGCAGCGGCCCCGGGA
CCACCTGCAGCATGATCACCTGGACAGCACCCACGAGACCACCAAGTACCTGAGTGAGGCCTGGCCTAAAGACGGTGGAAACGGCACCAG
CCCCGACTTCTCCCACTCCAAGGAGTGGTTCCACGACAGGGATCTGGGCCCCAACACCACCATCAAACTCTCCTAGGCCATGCCAAGACC
CAGGACATAGGACGGACCCCTGGTACCCAGAAGAGGAGTTCTTGCTCACTAACCCGGATCCGCCTCGTGCCCCTGCCTCCTGGAGCTTCC
CATTCCAGGAGAAAAGGCTCCACTTCCCAGCCCTTCCTTGCCCCTGACATTTGGACTCTTCCCTTGGGCCGACCACTCTGTTCTCATTCT
CCTTCCCACCAACATCCATCCGTCCTTCTCAGACAAACCACTCACTGGGTACCCCACCTCCTCTCTCATATGCCCAACACGACCACTGCC
TCCCTGCCCCCACACCTGCACCCAAACAGACACATCAACGCACCCCACTCACAGACACCCCTTACCCCACCCCCACTGTACAGAGACCAA
GAACAGAAATTGTTTGTAAATAATGAACCTTATTTTTTATTATTGCCAATCCCCTAAGATATTGTATTTTACAAATCTCCCTCTTCCCTT
CGCCCCTCCCTTGTTTTATATTTTATGAAGTTAGTGCGGGCTTTGCTGCTCCCTGGCCCAGGAAAGAGGGACTACCTGACCCTCACCTGG
CACCCCCCTGCTGCTGCCCAAGCCGCTGGGCCTTTTTAATTGCCAAACTGCTCTCTTCATCAGCTCAGCACATGCTTTAAGAAAGCAAAA

>59877_59877_6_NPEPPS-CREB3L1_NPEPPS_chr17_45623359_ENST00000544660_CREB3L1_chr11_46341815_ENST00000529193_length(amino acids)=200AA_BP=100
MLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDII
TASYAPEGDEVPSRSLLFYDDGAGLWEDGRSTLLPMEPPDGWEINPGGPAEQRPRDHLQHDHLDSTHETTKYLSEAWPKDGGNGTSPDFS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NPEPPS-CREB3L1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for NPEPPS-CREB3L1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for NPEPPS-CREB3L1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source