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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NPEPPS-NDUFAF2 (FusionGDB2 ID:59889)

Fusion Gene Summary for NPEPPS-NDUFAF2

check button Fusion gene summary
Fusion gene informationFusion gene name: NPEPPS-NDUFAF2
Fusion gene ID: 59889
HgeneTgene
Gene symbol

NPEPPS

NDUFAF2

Gene ID

9520

91942

Gene nameaminopeptidase puromycin sensitiveNADH:ubiquinone oxidoreductase complex assembly factor 2
SynonymsAAP-S|MP100|PSAB17.2L|MC1DN10|MMTN|NDUFA12L|mimitin
Cytomap

17q21.32

5q12.1

Type of geneprotein-codingprotein-coding
Descriptionpuromycin-sensitive aminopeptidasecytosol alanyl aminopeptidasemetalloproteinase MP100NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2Myc-induced mitochondrial proteinNADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2NADH dehydrogenase (ubiquinone) complex I, assembly factor 2NADH dehydrogenase 1
Modification date2020031320200313
UniProtAcc

P55786

Q8N183

Ensembl transtripts involved in fusion geneENST00000525037, ENST00000322157, 
ENST00000530173, ENST00000544660, 
ENST00000296597, ENST00000512623, 
ENST00000511107, 
Fusion gene scores* DoF score18 X 9 X 9=145813 X 7 X 9=819
# samples 1915
** MAII scorelog2(19/1458*10)=-2.93991939599599
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/819*10)=-2.44890095114513
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NPEPPS [Title/Abstract] AND NDUFAF2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNPEPPS(45646860)-NDUFAF2(60368951), # samples:1
NPEPPS(45646860)-NDUFAF2(60368952), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNPEPPS

GO:0071456

cellular response to hypoxia

21056661


check buttonFusion gene breakpoints across NPEPPS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NDUFAF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-20-1683-01ANPEPPSchr17

45646860

+NDUFAF2chr5

60368952

+
ChimerDB4OVTCGA-20-1683NPEPPSchr17

45646860

+NDUFAF2chr5

60368951

+


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Fusion Gene ORF analysis for NPEPPS-NDUFAF2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000525037ENST00000296597NPEPPSchr17

45646860

+NDUFAF2chr5

60368952

+
3UTR-3CDSENST00000525037ENST00000296597NPEPPSchr17

45646860

+NDUFAF2chr5

60368951

+
3UTR-3UTRENST00000525037ENST00000512623NPEPPSchr17

45646860

+NDUFAF2chr5

60368952

+
3UTR-3UTRENST00000525037ENST00000512623NPEPPSchr17

45646860

+NDUFAF2chr5

60368951

+
3UTR-intronENST00000525037ENST00000511107NPEPPSchr17

45646860

+NDUFAF2chr5

60368952

+
3UTR-intronENST00000525037ENST00000511107NPEPPSchr17

45646860

+NDUFAF2chr5

60368951

+
5CDS-3UTRENST00000322157ENST00000512623NPEPPSchr17

45646860

+NDUFAF2chr5

60368952

+
5CDS-3UTRENST00000322157ENST00000512623NPEPPSchr17

45646860

+NDUFAF2chr5

60368951

+
5CDS-3UTRENST00000530173ENST00000512623NPEPPSchr17

45646860

+NDUFAF2chr5

60368952

+
5CDS-3UTRENST00000530173ENST00000512623NPEPPSchr17

45646860

+NDUFAF2chr5

60368951

+
5CDS-3UTRENST00000544660ENST00000512623NPEPPSchr17

45646860

+NDUFAF2chr5

60368952

+
5CDS-3UTRENST00000544660ENST00000512623NPEPPSchr17

45646860

+NDUFAF2chr5

60368951

+
5CDS-intronENST00000322157ENST00000511107NPEPPSchr17

45646860

+NDUFAF2chr5

60368952

+
5CDS-intronENST00000322157ENST00000511107NPEPPSchr17

45646860

+NDUFAF2chr5

60368951

+
5CDS-intronENST00000530173ENST00000511107NPEPPSchr17

45646860

+NDUFAF2chr5

60368952

+
5CDS-intronENST00000530173ENST00000511107NPEPPSchr17

45646860

+NDUFAF2chr5

60368951

+
5CDS-intronENST00000544660ENST00000511107NPEPPSchr17

45646860

+NDUFAF2chr5

60368952

+
5CDS-intronENST00000544660ENST00000511107NPEPPSchr17

45646860

+NDUFAF2chr5

60368951

+
In-frameENST00000322157ENST00000296597NPEPPSchr17

45646860

+NDUFAF2chr5

60368952

+
In-frameENST00000322157ENST00000296597NPEPPSchr17

45646860

+NDUFAF2chr5

60368951

+
In-frameENST00000530173ENST00000296597NPEPPSchr17

45646860

+NDUFAF2chr5

60368952

+
In-frameENST00000530173ENST00000296597NPEPPSchr17

45646860

+NDUFAF2chr5

60368951

+
In-frameENST00000544660ENST00000296597NPEPPSchr17

45646860

+NDUFAF2chr5

60368952

+
In-frameENST00000544660ENST00000296597NPEPPSchr17

45646860

+NDUFAF2chr5

60368951

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000530173NPEPPSchr1745646860+ENST00000296597NDUFAF2chr560368951+89043630818262
ENST00000322157NPEPPSchr1745646860+ENST00000296597NDUFAF2chr560368951+1109655661037323
ENST00000544660NPEPPSchr1745646860+ENST00000296597NDUFAF2chr560368951+84639213774253
ENST00000530173NPEPPSchr1745646860+ENST00000296597NDUFAF2chr560368952+89043630818262
ENST00000322157NPEPPSchr1745646860+ENST00000296597NDUFAF2chr560368952+1109655661037323
ENST00000544660NPEPPSchr1745646860+ENST00000296597NDUFAF2chr560368952+84639213774253

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000530173ENST00000296597NPEPPSchr1745646860+NDUFAF2chr560368951+0.0024675780.99753237
ENST00000322157ENST00000296597NPEPPSchr1745646860+NDUFAF2chr560368951+0.0019854410.99801457
ENST00000544660ENST00000296597NPEPPSchr1745646860+NDUFAF2chr560368951+0.0017751360.9982249
ENST00000530173ENST00000296597NPEPPSchr1745646860+NDUFAF2chr560368952+0.0024675780.99753237
ENST00000322157ENST00000296597NPEPPSchr1745646860+NDUFAF2chr560368952+0.0019854410.99801457
ENST00000544660ENST00000296597NPEPPSchr1745646860+NDUFAF2chr560368952+0.0017751360.9982249

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Fusion Genomic Features for NPEPPS-NDUFAF2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NPEPPSchr1745646860+NDUFAF2chr560368951+1.87E-091
NPEPPSchr1745646860+NDUFAF2chr560368951+1.87E-091
NPEPPSchr1745646860+NDUFAF2chr560368951+1.87E-091
NPEPPSchr1745646860+NDUFAF2chr560368951+1.87E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NPEPPS-NDUFAF2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:45646860/chr5:60368951)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NPEPPS

P55786

NDUFAF2

Q8N183

FUNCTION: Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. {ECO:0000269|PubMed:10978616, ECO:0000269|PubMed:11062501, ECO:0000269|PubMed:17154549, ECO:0000269|PubMed:17318184, ECO:0000269|PubMed:19917696}.FUNCTION: Acts as a molecular chaperone for mitochondrial complex I assembly (PubMed:16200211, PubMed:19384974). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:16200211, PubMed:27626371). {ECO:0000269|PubMed:16200211, ECO:0000269|PubMed:19384974, ECO:0000269|PubMed:27626371}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNPEPPSchr17:45646860chr5:60368951ENST00000322157+323726_730139920.0MotifNuclear localization signal
HgeneNPEPPSchr17:45646860chr5:60368952ENST00000322157+323726_730139920.0MotifNuclear localization signal
HgeneNPEPPSchr17:45646860chr5:60368951ENST00000322157+323316_320139920.0RegionSubstrate binding
HgeneNPEPPSchr17:45646860chr5:60368952ENST00000322157+323316_320139920.0RegionSubstrate binding


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Fusion Gene Sequence for NPEPPS-NDUFAF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>59889_59889_1_NPEPPS-NDUFAF2_NPEPPS_chr17_45646860_ENST00000322157_NDUFAF2_chr5_60368951_ENST00000296597_length(transcript)=1109nt_BP=655nt
GGGCGCGCCCGGCCGGCGGGGCCGCGCACGCAGCCGCCGCCACCACTTCCCCCTCTCCCTCCCTCCTTGCGGGCCCTCCTCCCCTTCCCT
CCCCTCCGCCCCCTTCCCCGTAGGCAGCCCGCCCGCCAGTCCGCCCGCACCGCCTCCTTCCCAGCCCCTAGCGCTCCGGCTGGGTCTCTC
CCCCGCCCCCCAGGCTCCCCCGGTCGCTCTCCTCCGGCGGTCGCCCGCGCTCGGTGGATGTGGCTGGCAGCTGCCGCCCCCTCCCTCGCT
CGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGC
CTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTG
CTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATTGAT
ATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGAAATACATGCTACAGGATTTAACTATCAGAATGAAGATGAAAAAGTCACCTTG
TCTTTCCCTAGTACTCTGCAAACAGGACAAACTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAAGCA
GGGGATATTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAACAC
AGAGAAGAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCACCA
GTTCAAACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACCTTT
CAGCCAGGATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTATGGTCAAATCTTTTCATGTATATGGATGTGACTA

>59889_59889_1_NPEPPS-NDUFAF2_NPEPPS_chr17_45646860_ENST00000322157_NDUFAF2_chr5_60368951_ENST00000296597_length(amino acids)=323AA_BP=196
MRALLPFPPLRPLPRRQPARQSARTASFPAPSAPAGSLPRPPGSPGRSPPAVARARWMWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSS
RRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEEIHATGFNYQ
NEDEKVTLSFPSTLQTGQTIREKRIVEAANKKEVDYEAGDIPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKET

--------------------------------------------------------------
>59889_59889_2_NPEPPS-NDUFAF2_NPEPPS_chr17_45646860_ENST00000322157_NDUFAF2_chr5_60368952_ENST00000296597_length(transcript)=1109nt_BP=655nt
GGGCGCGCCCGGCCGGCGGGGCCGCGCACGCAGCCGCCGCCACCACTTCCCCCTCTCCCTCCCTCCTTGCGGGCCCTCCTCCCCTTCCCT
CCCCTCCGCCCCCTTCCCCGTAGGCAGCCCGCCCGCCAGTCCGCCCGCACCGCCTCCTTCCCAGCCCCTAGCGCTCCGGCTGGGTCTCTC
CCCCGCCCCCCAGGCTCCCCCGGTCGCTCTCCTCCGGCGGTCGCCCGCGCTCGGTGGATGTGGCTGGCAGCTGCCGCCCCCTCCCTCGCT
CGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGC
CTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTG
CTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATTGAT
ATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGAAATACATGCTACAGGATTTAACTATCAGAATGAAGATGAAAAAGTCACCTTG
TCTTTCCCTAGTACTCTGCAAACAGGACAAACTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAAGCA
GGGGATATTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAACAC
AGAGAAGAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCACCA
GTTCAAACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACCTTT
CAGCCAGGATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTATGGTCAAATCTTTTCATGTATATGGATGTGACTA

>59889_59889_2_NPEPPS-NDUFAF2_NPEPPS_chr17_45646860_ENST00000322157_NDUFAF2_chr5_60368952_ENST00000296597_length(amino acids)=323AA_BP=196
MRALLPFPPLRPLPRRQPARQSARTASFPAPSAPAGSLPRPPGSPGRSPPAVARARWMWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSS
RRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEEIHATGFNYQ
NEDEKVTLSFPSTLQTGQTIREKRIVEAANKKEVDYEAGDIPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKET

--------------------------------------------------------------
>59889_59889_3_NPEPPS-NDUFAF2_NPEPPS_chr17_45646860_ENST00000530173_NDUFAF2_chr5_60368951_ENST00000296597_length(transcript)=890nt_BP=436nt
AAGTTACGGAAGAGTCAAGGCTGGGACCTCATGGCATCATTTTCCATGGATTGCTCTCCAAGTTTTTGTGTTCCTGGCCTTTGGAACCCC
TTCATCATATTCCGCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTG
CCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCC
CAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGAA
ATACATGCTACAGGATTTAACTATCAGAATGAAGATGAAAAAGTCACCTTGTCTTTCCCTAGTACTCTGCAAACAGGACAAACTATTCGA
GAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAAGCAGGGGATATTCCAACAGAATGGGAAGCTTGGATTAGAAGA
ACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAACACAGAGAAGAAATCAAAATAAAAAGCCAAGATTTTTATGAA
AAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCACCAGTTCAAACTCAAATTAAAGGCCATGCCTCTGCTCCATAC
TTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACCTTTCAGCCAGGATCCTGGATGCCACGAGATGGCAAGAGCCAC

>59889_59889_3_NPEPPS-NDUFAF2_NPEPPS_chr17_45646860_ENST00000530173_NDUFAF2_chr5_60368951_ENST00000296597_length(amino acids)=262AA_BP=135
MASFSMDCSPSFCVPGLWNPFIIFRSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIV
MNCADIDIITASYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGQTIREKRIVEAANKKEVDYEAGDIPTEWEAWIRRTRKTPPTMEE

--------------------------------------------------------------
>59889_59889_4_NPEPPS-NDUFAF2_NPEPPS_chr17_45646860_ENST00000530173_NDUFAF2_chr5_60368952_ENST00000296597_length(transcript)=890nt_BP=436nt
AAGTTACGGAAGAGTCAAGGCTGGGACCTCATGGCATCATTTTCCATGGATTGCTCTCCAAGTTTTTGTGTTCCTGGCCTTTGGAACCCC
TTCATCATATTCCGCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTG
CCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCC
CAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGAA
ATACATGCTACAGGATTTAACTATCAGAATGAAGATGAAAAAGTCACCTTGTCTTTCCCTAGTACTCTGCAAACAGGACAAACTATTCGA
GAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAAGCAGGGGATATTCCAACAGAATGGGAAGCTTGGATTAGAAGA
ACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAACACAGAGAAGAAATCAAAATAAAAAGCCAAGATTTTTATGAA
AAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCACCAGTTCAAACTCAAATTAAAGGCCATGCCTCTGCTCCATAC
TTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACCTTTCAGCCAGGATCCTGGATGCCACGAGATGGCAAGAGCCAC

>59889_59889_4_NPEPPS-NDUFAF2_NPEPPS_chr17_45646860_ENST00000530173_NDUFAF2_chr5_60368952_ENST00000296597_length(amino acids)=262AA_BP=135
MASFSMDCSPSFCVPGLWNPFIIFRSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIV
MNCADIDIITASYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGQTIREKRIVEAANKKEVDYEAGDIPTEWEAWIRRTRKTPPTMEE

--------------------------------------------------------------
>59889_59889_5_NPEPPS-NDUFAF2_NPEPPS_chr17_45646860_ENST00000544660_NDUFAF2_chr5_60368951_ENST00000296597_length(transcript)=846nt_BP=392nt
CCTCGCTCGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAG
CCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCC
CGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGA
TATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGAAATACATGCTACAGGATTTAACTATCAGAATGAAGATGAAAAAGT
CACCTTGTCTTTCCCTAGTACTCTGCAAACAGGACAAACTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTA
TGAAGCAGGGGATATTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGA
AAAACACAGAGAAGAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCC
TCCACCAGTTCAAACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAA
AACCTTTCAGCCAGGATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTATGGTCAAATCTTTTCATGTATATGGAT

>59889_59889_5_NPEPPS-NDUFAF2_NPEPPS_chr17_45646860_ENST00000544660_NDUFAF2_chr5_60368951_ENST00000296597_length(amino acids)=253AA_BP=126
MLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDII
TASYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGQTIREKRIVEAANKKEVDYEAGDIPTEWEAWIRRTRKTPPTMEEILKNEKHRE

--------------------------------------------------------------
>59889_59889_6_NPEPPS-NDUFAF2_NPEPPS_chr17_45646860_ENST00000544660_NDUFAF2_chr5_60368952_ENST00000296597_length(transcript)=846nt_BP=392nt
CCTCGCTCGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAG
CCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCC
CGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGA
TATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGAAATACATGCTACAGGATTTAACTATCAGAATGAAGATGAAAAAGT
CACCTTGTCTTTCCCTAGTACTCTGCAAACAGGACAAACTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTA
TGAAGCAGGGGATATTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGA
AAAACACAGAGAAGAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCC
TCCACCAGTTCAAACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAA
AACCTTTCAGCCAGGATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTATGGTCAAATCTTTTCATGTATATGGAT

>59889_59889_6_NPEPPS-NDUFAF2_NPEPPS_chr17_45646860_ENST00000544660_NDUFAF2_chr5_60368952_ENST00000296597_length(amino acids)=253AA_BP=126
MLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDII
TASYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGQTIREKRIVEAANKKEVDYEAGDIPTEWEAWIRRTRKTPPTMEEILKNEKHRE

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Fusion Gene PPI Analysis for NPEPPS-NDUFAF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NPEPPS-NDUFAF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NPEPPS-NDUFAF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource