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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:NPHP4-CDKN2A (FusionGDB2 ID:59904)

Fusion Gene Summary for NPHP4-CDKN2A

Fusion gene summary

Fusion gene information	Fusion gene name: NPHP4-CDKN2A
	Fusion gene ID: 59904
		Hgene	Tgene
	Gene symbol	NPHP4	CDKN2A
	Gene ID	261734	1029
	Gene name	nephrocystin 4	cyclin dependent kinase inhibitor 2A
	Synonyms	POC10\|SLSN4	ARF\|CDK4I\|CDKN2\|CMM2\|INK4\|INK4A\|MLM\|MTS-1\|MTS1\|P14\|P14ARF\|P16\|P16-INK4A\|P16INK4\|P16INK4A\|P19\|P19ARF\|TP16
	Cytomap	1p36.31	9p21.3
	Type of gene	protein-coding	protein-coding
	Description	nephrocystin-4POC10 centriolar protein homolognephroretinin	cyclin-dependent kinase inhibitor 2ACDK4 inhibitor p16-INK4alternative reading framecell cycle negative regulator betacyclin-dependent kinase 4 inhibitor Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)multiple tumor suppressor 1
	Modification date	20200320	20200329
	UniProtAcc	O75161	Q96HQ2
	Ensembl transtripts involved in fusion gene	ENST00000378156, ENST00000478423,	ENST00000446177, ENST00000479692, ENST00000494262, ENST00000497750, ENST00000498124, ENST00000498628, ENST00000530628, ENST00000578845, ENST00000470819, ENST00000361570, ENST00000579755, ENST00000304494, ENST00000579122,
Fusion gene scores	* DoF score	7 X 10 X 5=350	13 X 5 X 10=650
	# samples	10	16
	** MAII score	log2(10/350*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/650*10)=-2.02236781302845 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NPHP4 [Title/Abstract] AND CDKN2A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NPHP4(6046215)-CDKN2A(21971207), # samples:3
Anticipated loss of major functional domain due to fusion event.	NPHP4-CDKN2A seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. NPHP4-CDKN2A seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NPHP4	GO:0090090	negative regulation of canonical Wnt signaling pathway	22654112
Tgene	CDKN2A	GO:0000082	G1/S transition of mitotic cell cycle	10208428
Tgene	CDKN2A	GO:0007050	cell cycle arrest	15149599
Tgene	CDKN2A	GO:0008285	negative regulation of cell proliferation	15149599
Tgene	CDKN2A	GO:0030308	negative regulation of cell growth	10208428
Tgene	CDKN2A	GO:0032088	negative regulation of NF-kappaB transcription factor activity	10353611
Tgene	CDKN2A	GO:0042326	negative regulation of phosphorylation	8259215\|10208428
Tgene	CDKN2A	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	7739547\|8259215

Fusion gene breakpoints across NPHP4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CDKN2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-EE-A20H-06A	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-

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Fusion Gene ORF analysis for NPHP4-CDKN2A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000378156	ENST00000446177	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-
5CDS-5UTR	ENST00000378156	ENST00000479692	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-
5CDS-5UTR	ENST00000378156	ENST00000494262	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-
5CDS-5UTR	ENST00000378156	ENST00000497750	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-
5CDS-5UTR	ENST00000378156	ENST00000498124	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-
5CDS-5UTR	ENST00000378156	ENST00000498628	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-
5CDS-5UTR	ENST00000378156	ENST00000530628	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-
5CDS-5UTR	ENST00000378156	ENST00000578845	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-
5CDS-intron	ENST00000378156	ENST00000470819	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-
Frame-shift	ENST00000378156	ENST00000361570	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-
Frame-shift	ENST00000378156	ENST00000579755	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-
In-frame	ENST00000378156	ENST00000304494	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-
In-frame	ENST00000378156	ENST00000579122	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-
intron-3CDS	ENST00000478423	ENST00000304494	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-
intron-3CDS	ENST00000478423	ENST00000361570	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-
intron-3CDS	ENST00000478423	ENST00000579122	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-
intron-3CDS	ENST00000478423	ENST00000579755	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-
intron-5UTR	ENST00000478423	ENST00000446177	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-
intron-5UTR	ENST00000478423	ENST00000479692	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-
intron-5UTR	ENST00000478423	ENST00000494262	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-
intron-5UTR	ENST00000478423	ENST00000497750	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-
intron-5UTR	ENST00000478423	ENST00000498124	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-
intron-5UTR	ENST00000478423	ENST00000498628	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-
intron-5UTR	ENST00000478423	ENST00000530628	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-
intron-5UTR	ENST00000478423	ENST00000578845	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-
intron-intron	ENST00000478423	ENST00000470819	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000378156	NPHP4	chr1	6046215	-	ENST00000304494	CDKN2A	chr9	21971207	-	1198	401	711	253	152
ENST00000378156	NPHP4	chr1	6046215	-	ENST00000579122	CDKN2A	chr9	21971207	-	886	401	637	224	137

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000378156	ENST00000304494	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-	0.13914774	0.86085224
ENST00000378156	ENST00000579122	NPHP4	chr1	6046215	-	CDKN2A	chr9	21971207	-	0.32081422	0.6791858

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Fusion Genomic Features for NPHP4-CDKN2A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NPHP4-CDKN2A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:6046215/chr9:21971207)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NPHP4 O75161	CDKN2A Q96HQ2
FUNCTION: Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462). {ECO:0000250\|UniProtKB:B0DOB4, ECO:0000250\|UniProtKB:P59240, ECO:0000269\|PubMed:21498478, ECO:0000269\|PubMed:21555462, ECO:0000269\|PubMed:21565611, ECO:0000269\|PubMed:22654112, ECO:0000305\|PubMed:19755384}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CDKN2A

chr1:6046215

chr9:21971207

ENST00000304494

110_139

157.0

Repeat

Note=ANK 4

Tgene

CDKN2A

chr1:6046215

chr9:21971207

ENST00000304494

77_106

157.0

Repeat

Note=ANK 3

Tgene

CDKN2A

chr1:6046215

chr9:21971207

ENST00000446177

110_139

168.0

Repeat

Note=ANK 4

Tgene

CDKN2A

chr1:6046215

chr9:21971207

ENST00000446177

77_106

168.0

Repeat

Note=ANK 3

Tgene

CDKN2A

chr1:6046215

chr9:21971207

ENST00000494262

110_139

106.0

Repeat

Note=ANK 4

Tgene

CDKN2A

chr1:6046215

chr9:21971207

ENST00000494262

11_40

106.0

Repeat

Note=ANK 1

Tgene

CDKN2A

chr1:6046215

chr9:21971207

ENST00000494262

44_72

106.0

Repeat

Note=ANK 2

Tgene

CDKN2A

chr1:6046215

chr9:21971207

ENST00000494262

77_106

106.0

Repeat

Note=ANK 3

Tgene

CDKN2A

chr1:6046215

chr9:21971207

ENST00000498124

110_139

130.66666666666666

Repeat

Note=ANK 4

Tgene

CDKN2A

chr1:6046215

chr9:21971207

ENST00000498124

77_106

130.66666666666666

Repeat

Note=ANK 3

Tgene

CDKN2A

chr1:6046215

chr9:21971207

ENST00000498628

110_139

106.0

Repeat

Note=ANK 4

Tgene

CDKN2A

chr1:6046215

chr9:21971207

ENST00000498628

11_40

106.0

Repeat

Note=ANK 1

Tgene

CDKN2A

chr1:6046215

chr9:21971207

ENST00000498628

44_72

106.0

Repeat

Note=ANK 2

Tgene

CDKN2A

chr1:6046215

chr9:21971207

ENST00000498628

77_106

106.0

Repeat

Note=ANK 3

Tgene

CDKN2A

chr1:6046215

chr9:21971207

ENST00000578845

110_139

106.0

Repeat

Note=ANK 4

Tgene

CDKN2A

chr1:6046215

chr9:21971207

ENST00000578845

11_40

106.0

Repeat

Note=ANK 1

Tgene

CDKN2A

chr1:6046215

chr9:21971207

ENST00000578845

44_72

106.0

Repeat

Note=ANK 2

Tgene

CDKN2A

chr1:6046215

chr9:21971207

ENST00000578845

77_106

106.0

Repeat

Note=ANK 3

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NPHP4

chr1:6046215

chr9:21971207

ENST00000378156

823_1426

1427.0

Region

Sufficient for basal bodies localization

Tgene

CDKN2A

chr1:6046215

chr9:21971207

ENST00000304494

11_40

157.0

Repeat

Note=ANK 1

Tgene

CDKN2A

chr1:6046215

chr9:21971207

ENST00000304494

44_72

157.0

Repeat

Note=ANK 2

Tgene

CDKN2A

chr1:6046215

chr9:21971207

ENST00000446177

11_40

168.0

Repeat

Note=ANK 1

Tgene

CDKN2A

chr1:6046215

chr9:21971207

ENST00000446177

44_72

168.0

Repeat

Note=ANK 2

Tgene

CDKN2A

chr1:6046215

chr9:21971207

ENST00000498124

11_40

130.66666666666666

Repeat

Note=ANK 1

Tgene

CDKN2A

chr1:6046215

chr9:21971207

ENST00000498124

44_72

130.66666666666666

Repeat

Note=ANK 2

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Fusion Gene Sequence for NPHP4-CDKN2A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>59904_59904_1_NPHP4-CDKN2A_NPHP4_chr1_6046215_ENST00000378156_CDKN2A_chr9_21971207_ENST00000304494_length(transcript)=1198nt_BP=401nt
GACGCGAGGCGGGTTCTTGGACTGAGTGTGCGGCGCGGTGCGCCGCCTTCCGAGGCTCCTCCCGCGGGTGGCAGCGGACGGGGCGCGCCC
CTCGGCCAGTCCTCGGTCCTCAGGCTTGTGGCTCCGTTGAGCACCGGCCGCCGGGCCTCTGGGTCCGTCGAGTGGAGACTCTCTGAAAAG
CGTGGGCTCCGTGGCCTCCGGCGCGGCCGCGGCGGGTCGGTCTCCTAGATCATCCGGGAAGCCCACGGGACCCTCAGGCGGGCAGGATGA
ACGACTGGCACAGGATCTTCACCCAAAACGTGCTTGTCCCTCCCCACCCACAGAGAGCGCGCCAGCCTTGGAAGGAATCCACGGCATTCC
AGTGTGTCCTCAAGTGGCTGGACGGACCGGTAATTAGGCAGGTCATGATGATGGGCAGCGCCCGAGTGGCGGAGCTGCTGCTGCTCCACG
GCGCGGAGCCCAACTGCGCCGACCCCGCCACTCTCACCCGACCCGTGCACGACGCTGCCCGGGAGGGCTTCCTGGACACGCTGGTGGTGC
TGCACCGGGCCGGGGCGCGGCTGGACGTGCGCGATGCCTGGGGCCGTCTGCCCGTGGACCTGGCTGAGGAGCTGGGCCATCGCGATGTCG
CACGGTACCTGCGCGCGGCTGCGGGGGGCACCAGAGGCAGTAACCATGCCCGCATAGATGCCGCGGAAGGTCCCTCAGACATCCCCGATT
GAAAGAACCAGAGAGGCTCTGAGAAACCTCGGGAAACTTAGATCATCAGTCACCGAAGGTCCTACAGGGCCACAACTGCCCCCGCCACAA
CCCACCCCGCTTTCGTAGTTTTCATTTAGAAAATAGAGCTTTTAAAAATGTCCTGCCTTTTAACGTAGATATATGCCTTCCCCCACTACC
GTAAATGTCCATTTATATCATTTTTTATATATTCTTATAAAAATGTAAAAAAGAAAAACACCGCTTCTGCCTTTTCACTGTGTTGGAGTT
TTCTGGAGTGAGCACTCACGCCCTAAGCGCACATTCATGTGGGCATTTCTTGCGAGCCTCGCAGCCTCCGGAAGCTGTCGACTTCATGAC
AAGCATTTTGTGAACTAGGGAAGCTCAGGGGGGTTACTGGCTTCTCTTGAGTCACACTGCTAGCAAATGGCAGAACCAAAGCTCAAATAA

>59904_59904_1_NPHP4-CDKN2A_NPHP4_chr1_6046215_ENST00000378156_CDKN2A_chr9_21971207_ENST00000304494_length(amino acids)=152AA_BP=2
MSEGPSAASMRAWLLPLVPPAAARRYRATSRWPSSSARSTGRRPQASRTSSRAPARCSTTSVSRKPSRAASCTGRVRVAGSAQLGSAPWS

--------------------------------------------------------------
>59904_59904_2_NPHP4-CDKN2A_NPHP4_chr1_6046215_ENST00000378156_CDKN2A_chr9_21971207_ENST00000579122_length(transcript)=886nt_BP=401nt
GACGCGAGGCGGGTTCTTGGACTGAGTGTGCGGCGCGGTGCGCCGCCTTCCGAGGCTCCTCCCGCGGGTGGCAGCGGACGGGGCGCGCCC
CTCGGCCAGTCCTCGGTCCTCAGGCTTGTGGCTCCGTTGAGCACCGGCCGCCGGGCCTCTGGGTCCGTCGAGTGGAGACTCTCTGAAAAG
CGTGGGCTCCGTGGCCTCCGGCGCGGCCGCGGCGGGTCGGTCTCCTAGATCATCCGGGAAGCCCACGGGACCCTCAGGCGGGCAGGATGA
ACGACTGGCACAGGATCTTCACCCAAAACGTGCTTGTCCCTCCCCACCCACAGAGAGCGCGCCAGCCTTGGAAGGAATCCACGGCATTCC
AGTGTGTCCTCAAGTGGCTGGACGGACCGGTAATTAGGCAGGTCATGATGATGGGCAGCGCCCGAGTGGCGGAGCTGCTGCTGCTCCACG
GCGCGGAGCCCAACTGCGCCGACCCCGCCACTCTCACCCGACCCGTGCACGACGCTGCCCGGGAGGGCTTCCTGGACACGCTGGTGGTGC
TGCACCGGGCCGGGGCGCGGCTGGACGTGCGCGATGCCTGGGGCCGTCTGCCCGTGGACCTGGCTGAGGAGCTGGGCCATCGCGATGTCG
CACGACATCCCCGATTGAAAGAACCAGAGAGGCTCTGAGAAACCTCGGGAAACTTAGATCATCAGTCACCGAAGGTCCTACAGGGCCACA
ACTGCCCCCGCCACAACCCACCCCGCTTTCGTAGTTTTCATTTAGAAAATAGAGCTTTTAAAAATGTCCTGCCTTTTAACGTAGATATAT

>59904_59904_2_NPHP4-CDKN2A_NPHP4_chr1_6046215_ENST00000378156_CDKN2A_chr9_21971207_ENST00000579122_length(amino acids)=137AA_BP=2
MSCDIAMAQLLSQVHGQTAPGIAHVQPRPGPVQHHQRVQEALPGSVVHGSGESGGVGAVGLRAVEQQQLRHSGAAHHHDLPNYRSVQPLE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NPHP4-CDKN2A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	CDKN2A	chr1:6046215	chr9:21971207	ENST00000361570		0	3	1_64	105.33333333333333	220.0	CDK5RAP3 and MDM2
Tgene	CDKN2A	chr1:6046215	chr9:21971207	ENST00000530628		0	3	1_64	64.33333333333333	122.66666666666667	CDK5RAP3 and MDM2
Tgene	CDKN2A	chr1:6046215	chr9:21971207	ENST00000579755		0	3	1_64	64.33333333333333	134.33333333333334	CDK5RAP3 and MDM2

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for NPHP4-CDKN2A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for NPHP4-CDKN2A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source