FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:NPLOC4-ALYREF (FusionGDB2 ID:59941)

Fusion Gene Summary for NPLOC4-ALYREF

check button Fusion gene summary
Fusion gene informationFusion gene name: NPLOC4-ALYREF
Fusion gene ID: 59941
HgeneTgene
Gene symbol

NPLOC4

ALYREF

Gene ID

55666

10189

Gene nameNPL4 homolog, ubiquitin recognition factorAly/REF export factor
SynonymsNPL4ALY|ALY/REF|BEF|REF|THOC4
Cytomap

17q25.3

17q25.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear protein localization protein 4 homologNPLOC4 ubiquitin recognition factornuclear protein localization 4 homologTHO complex subunit 4THO complex 4ally of AML-1 and LEF-1bZIP enhancing factorbZIP-enhancing factor BEFtho4transcriptional coactivator Aly/REF
Modification date2020031320200313
UniProtAcc

Q8TAT6

Q86V81

Ensembl transtripts involved in fusion geneENST00000331134, ENST00000374747, 
ENST00000539314, ENST00000572760, 
ENST00000573876, ENST00000574344, 
ENST00000512673, ENST00000331204, 
ENST00000505490, 
Fusion gene scores* DoF score19 X 17 X 11=35533 X 3 X 3=27
# samples 304
** MAII scorelog2(30/3553*10)=-3.56600328283534
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NPLOC4 [Title/Abstract] AND ALYREF [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNPLOC4(79567367)-ALYREF(79848696), # samples:2
NPLOC4(79589192)-ALYREF(79846021), # samples:2
Anticipated loss of major functional domain due to fusion event.NPLOC4-ALYREF seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NPLOC4-ALYREF seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneALYREF

GO:0006405

RNA export from nucleus

28418038

TgeneALYREF

GO:0046784

viral mRNA export from host cell nucleus

18974867


check buttonFusion gene breakpoints across NPLOC4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ALYREF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-FV-A496-01ANPLOC4chr17

79567367

-ALYREFchr17

79848696

-
ChimerDB4READTCGA-AF-6655-01ANPLOC4chr17

79589192

-ALYREFchr17

79846021

-
ChimerDB4READTCGA-AF-6655NPLOC4chr17

79589192

-ALYREFchr17

79846021

-


Top

Fusion Gene ORF analysis for NPLOC4-ALYREF

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000331134ENST00000512673NPLOC4chr17

79567367

-ALYREFchr17

79848696

-
5CDS-5UTRENST00000374747ENST00000512673NPLOC4chr17

79567367

-ALYREFchr17

79848696

-
5CDS-5UTRENST00000539314ENST00000512673NPLOC4chr17

79567367

-ALYREFchr17

79848696

-
5CDS-intronENST00000331134ENST00000512673NPLOC4chr17

79589192

-ALYREFchr17

79846021

-
5CDS-intronENST00000374747ENST00000512673NPLOC4chr17

79589192

-ALYREFchr17

79846021

-
5UTR-3CDSENST00000539314ENST00000331204NPLOC4chr17

79589192

-ALYREFchr17

79846021

-
5UTR-3CDSENST00000539314ENST00000505490NPLOC4chr17

79589192

-ALYREFchr17

79846021

-
5UTR-intronENST00000539314ENST00000512673NPLOC4chr17

79589192

-ALYREFchr17

79846021

-
Frame-shiftENST00000331134ENST00000331204NPLOC4chr17

79589192

-ALYREFchr17

79846021

-
Frame-shiftENST00000331134ENST00000505490NPLOC4chr17

79589192

-ALYREFchr17

79846021

-
Frame-shiftENST00000374747ENST00000331204NPLOC4chr17

79589192

-ALYREFchr17

79846021

-
Frame-shiftENST00000374747ENST00000505490NPLOC4chr17

79589192

-ALYREFchr17

79846021

-
Frame-shiftENST00000539314ENST00000331204NPLOC4chr17

79567367

-ALYREFchr17

79848696

-
Frame-shiftENST00000539314ENST00000505490NPLOC4chr17

79567367

-ALYREFchr17

79848696

-
In-frameENST00000331134ENST00000331204NPLOC4chr17

79567367

-ALYREFchr17

79848696

-
In-frameENST00000331134ENST00000505490NPLOC4chr17

79567367

-ALYREFchr17

79848696

-
In-frameENST00000374747ENST00000331204NPLOC4chr17

79567367

-ALYREFchr17

79848696

-
In-frameENST00000374747ENST00000505490NPLOC4chr17

79567367

-ALYREFchr17

79848696

-
intron-3CDSENST00000572760ENST00000331204NPLOC4chr17

79567367

-ALYREFchr17

79848696

-
intron-3CDSENST00000572760ENST00000331204NPLOC4chr17

79589192

-ALYREFchr17

79846021

-
intron-3CDSENST00000572760ENST00000505490NPLOC4chr17

79567367

-ALYREFchr17

79848696

-
intron-3CDSENST00000572760ENST00000505490NPLOC4chr17

79589192

-ALYREFchr17

79846021

-
intron-3CDSENST00000573876ENST00000331204NPLOC4chr17

79567367

-ALYREFchr17

79848696

-
intron-3CDSENST00000573876ENST00000331204NPLOC4chr17

79589192

-ALYREFchr17

79846021

-
intron-3CDSENST00000573876ENST00000505490NPLOC4chr17

79567367

-ALYREFchr17

79848696

-
intron-3CDSENST00000573876ENST00000505490NPLOC4chr17

79589192

-ALYREFchr17

79846021

-
intron-3CDSENST00000574344ENST00000331204NPLOC4chr17

79567367

-ALYREFchr17

79848696

-
intron-3CDSENST00000574344ENST00000331204NPLOC4chr17

79589192

-ALYREFchr17

79846021

-
intron-3CDSENST00000574344ENST00000505490NPLOC4chr17

79567367

-ALYREFchr17

79848696

-
intron-3CDSENST00000574344ENST00000505490NPLOC4chr17

79589192

-ALYREFchr17

79846021

-
intron-5UTRENST00000572760ENST00000512673NPLOC4chr17

79567367

-ALYREFchr17

79848696

-
intron-5UTRENST00000573876ENST00000512673NPLOC4chr17

79567367

-ALYREFchr17

79848696

-
intron-5UTRENST00000574344ENST00000512673NPLOC4chr17

79567367

-ALYREFchr17

79848696

-
intron-intronENST00000572760ENST00000512673NPLOC4chr17

79589192

-ALYREFchr17

79846021

-
intron-intronENST00000573876ENST00000512673NPLOC4chr17

79589192

-ALYREFchr17

79846021

-
intron-intronENST00000574344ENST00000512673NPLOC4chr17

79589192

-ALYREFchr17

79846021

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000331134NPLOC4chr1779567367-ENST00000331204ALYREFchr1779848696-1968113731673556
ENST00000331134NPLOC4chr1779567367-ENST00000505490ALYREFchr1779848696-1961113731673556
ENST00000374747NPLOC4chr1779567367-ENST00000331204ALYREFchr1779848696-1882105111587528
ENST00000374747NPLOC4chr1779567367-ENST00000505490ALYREFchr1779848696-1875105111587528

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000331134ENST00000331204NPLOC4chr1779567367-ALYREFchr1779848696-0.0042231610.9957768
ENST00000331134ENST00000505490NPLOC4chr1779567367-ALYREFchr1779848696-0.003948860.99605113
ENST00000374747ENST00000331204NPLOC4chr1779567367-ALYREFchr1779848696-0.0040999490.9959001
ENST00000374747ENST00000505490NPLOC4chr1779567367-ALYREFchr1779848696-0.0038492880.99615073

Top

Fusion Genomic Features for NPLOC4-ALYREF


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for NPLOC4-ALYREF


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:79567367/chr17:79848696)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NPLOC4

Q8TAT6

ALYREF

Q86V81

FUNCTION: The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729). {ECO:0000250|UniProtKB:Q9ES54, ECO:0000269|PubMed:26471729}.FUNCTION: Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway) (PubMed:15833825, PubMed:15998806, PubMed:17190602, PubMed:11707413, PubMed:11675789, PubMed:11979277, PubMed:18364396, PubMed:22144908, PubMed:22893130, PubMed:23222130, PubMed:25662211). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm (PubMed:15833825, PubMed:15998806, PubMed:17190602). TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1 (PubMed:15833825, PubMed:15998806, PubMed:17190602). The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production; ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA (PubMed:18974867). Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC) (PubMed:15998806, PubMed:17984224). In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim (PubMed:19165146). Involved in the nuclear export of intronless mRNA; proposed to be recruited to intronless mRNA by ATP-bound DDX39B. Involved in transcription elongation and genome stability (PubMed:12438613, PubMed:17984224). Involved in mRNA export of C5-methylcytosine (m5C)-containing mRNAs: specifically recognizes and binds m5C mRNAs and mediates their nucleo-cytoplasmic shuttling (PubMed:28418038). {ECO:0000269|PubMed:11675789, ECO:0000269|PubMed:11707413, ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:12438613, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:17984224, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:18974867, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:22144908, ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:25662211, ECO:0000269|PubMed:28418038}.; FUNCTION: Acts as chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation. {ECO:0000269|PubMed:10488337}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneALYREFchr17:79567367chr17:79848696ENST0000033120406106_18379258.0DomainRRM

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNPLOC4chr17:79567367chr17:79848696ENST00000331134-917226_363307609.0DomainMPN
HgeneNPLOC4chr17:79567367chr17:79848696ENST00000374747-916226_363307618.0DomainMPN
HgeneNPLOC4chr17:79567367chr17:79848696ENST00000331134-917580_608307609.0Zinc fingerRanBP2-type
HgeneNPLOC4chr17:79567367chr17:79848696ENST00000374747-916580_608307618.0Zinc fingerRanBP2-type
TgeneALYREFchr17:79567367chr17:79848696ENST000003312040621_23179258.0Compositional biasNote=Ala/Arg/Gly-rich


Top

Fusion Gene Sequence for NPLOC4-ALYREF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>59941_59941_1_NPLOC4-ALYREF_NPLOC4_chr17_79567367_ENST00000331134_ALYREF_chr17_79848696_ENST00000331204_length(transcript)=1968nt_BP=1137nt
AACCTGGTTTCCCGGCCTCGCGCCCGAGGGGAGCGTATTGAGCGAGGCACCGGGACGTCGGCGGCTGGCGGAGCCGGGCGGGCGAAGCTG
GAGCGGCGGTGGCGGCGGCGTAGGGAGGCCGGGGCCGGGGCTGAGGCCGCGGCCGGGTCTGCGAGGCCCTTGGGGCGGCAGGCGGCGGCG
GCCCGGGGCTCGAGCCCGGAGGCAGGAGCAGCCGCCATGGCCGAGAGCATCATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCGGATC
ACAGCAACAAAGAGAGAAACAGCAGCAACATTTTTGAAAAAGGTTGCAAAGGAGTTTGGCTTCCAAAATAATGGCTTCTCGGTTTACATC
AATAGAAACAAGACCGGAGAGATAACAGCCTCCTCCAACAAATCCCTCAACTTGCTAAAAATCAAGCATGGCGATTTGTTGTTCCTGTTT
CCCTCGAGCCTTGCTGGGCCCTCATCTGAAATGGAGACGTCAGTTCCACCGGGCTTCAAAGTCTTTGGCGCTCCCAACGTGGTGGAGGAT
GAGATTGATCAGTACCTCAGCAAACAGGACGGGAAGATTTACAGAAGCCGAGACCCACAGCTATGCCGCCACGGCCCTTTGGGGAAATGC
GTGCACTGCGTCCCTCTAGAGCCATTCGATGAGGACTATCTAAACCATCTCGAGCCTCCCGTGAAGCACATGTCCTTCCACGCCTACATC
CGGAAGCTGACTGGAGGGGCTGACAAGGGGAAGTTTGTTGCCCTGGAGAACATCAGCTGCAAGATTAAGTCAGGGTGCGAGGGGCACCTC
CCGTGGCCGAATGGCATCTGTACTAAGTGCCAGCCGAGCGCCATCACGCTGAACAGACAGAAGTACAGGCATGTGGACAATATCATGTTT
GAGAATCACACCGTCGCTGACCGCTTTCTTGACTTCTGGAGAAAGACAGGGAACCAGCATTTTGGGTACTTATACGGACGGTACACGGAG
CACAAAGACATTCCCCTTGGCATCAGGGCTGAAGTGGCTGCGATTTATGAGCCACCTCAGATTGGTACACAGAACAGCTTGGAGCTTCTT
GAGGATCCAAAAGCTGAAGTGGTCGATGAAATTGCTGCCAAACTTGGCCTGCGGAAGCCAAAACAACTTCCCGACAAGTGGCAGCACGAT
CTTTTCGACAGTGGCTTCGGCGGTGGTGCCGGCGTGGAGACAGGTGGGAAACTGCTGGTGTCCAATCTGGATTTTGGAGTCTCAGACGCC
GATATTCAGGAACTCTTTGCTGAATTTGGAACGCTGAAGAAGGCGGCTGTGCACTATGATCGCTCTGGTCGCAGCTTAGGAACAGCAGAC
GTGCACTTTGAGCGGAAGGCAGATGCCCTGAAGGCCATGAAGCAGTACAACGGCGTCCCTCTGGATGGCCGCCCCATGAACATTCAGCTT
GTCACGTCACAGATTGACGCACAGCGGAGGCCTGCACAGAGCGTAAACAGAGGTGGCATGACTAGAAACCGTGGCGCTGGAGGTTTTGGT
GGTGGTGGAGGCACCCGGAGAGGCACCCGCGGAGGCGCCCGTGGAAGAGGCAGAGGTGCCGGCAGGAATTCAAAGCAGCAGCTTTCGGCA
GAGGAGCTGGATGCCCAGCTGGACGCCTATAATGCGAGAATGGACACCAGTTAAACAGACCAGCAAATCCGCGTGCGGAACAGGACCCAG
GCGTCTCCTCTTGCTCCCTGGTTGGGGGGCGGTGGCTGGGGCTGTGCGGCCAATGATGGATTTGTTTCTTTTATGTTTTAAAATAGGATT
TAAAAACTCATGTAAAGGTTTTTTTTTTTTCTTTTTTTTTTTTTTTAATTCTGAAACAGACCTGTTTTGTACCGAGTTATTTTTGGGATA

>59941_59941_1_NPLOC4-ALYREF_NPLOC4_chr17_79567367_ENST00000331134_ALYREF_chr17_79848696_ENST00000331204_length(amino acids)=556AA_BP=20
MVSRPRARGERIERGTGTSAAGGAGRAKLERRWRRRREAGAGAEAAAGSARPLGRQAAAARGSSPEAGAAAMAESIIIRVQSPDGVKRIT
ATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASSNKSLNLLKIKHGDLLFLFPSSLAGPSSEMETSVPPGFKVFGAPNVVEDE
IDQYLSKQDGKIYRSRDPQLCRHGPLGKCVHCVPLEPFDEDYLNHLEPPVKHMSFHAYIRKLTGGADKGKFVALENISCKIKSGCEGHLP
WPNGICTKCQPSAITLNRQKYRHVDNIMFENHTVADRFLDFWRKTGNQHFGYLYGRYTEHKDIPLGIRAEVAAIYEPPQIGTQNSLELLE
DPKAEVVDEIAAKLGLRKPKQLPDKWQHDLFDSGFGGGAGVETGGKLLVSNLDFGVSDADIQELFAEFGTLKKAAVHYDRSGRSLGTADV
HFERKADALKAMKQYNGVPLDGRPMNIQLVTSQIDAQRRPAQSVNRGGMTRNRGAGGFGGGGGTRRGTRGGARGRGRGAGRNSKQQLSAE

--------------------------------------------------------------
>59941_59941_2_NPLOC4-ALYREF_NPLOC4_chr17_79567367_ENST00000331134_ALYREF_chr17_79848696_ENST00000505490_length(transcript)=1961nt_BP=1137nt
AACCTGGTTTCCCGGCCTCGCGCCCGAGGGGAGCGTATTGAGCGAGGCACCGGGACGTCGGCGGCTGGCGGAGCCGGGCGGGCGAAGCTG
GAGCGGCGGTGGCGGCGGCGTAGGGAGGCCGGGGCCGGGGCTGAGGCCGCGGCCGGGTCTGCGAGGCCCTTGGGGCGGCAGGCGGCGGCG
GCCCGGGGCTCGAGCCCGGAGGCAGGAGCAGCCGCCATGGCCGAGAGCATCATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCGGATC
ACAGCAACAAAGAGAGAAACAGCAGCAACATTTTTGAAAAAGGTTGCAAAGGAGTTTGGCTTCCAAAATAATGGCTTCTCGGTTTACATC
AATAGAAACAAGACCGGAGAGATAACAGCCTCCTCCAACAAATCCCTCAACTTGCTAAAAATCAAGCATGGCGATTTGTTGTTCCTGTTT
CCCTCGAGCCTTGCTGGGCCCTCATCTGAAATGGAGACGTCAGTTCCACCGGGCTTCAAAGTCTTTGGCGCTCCCAACGTGGTGGAGGAT
GAGATTGATCAGTACCTCAGCAAACAGGACGGGAAGATTTACAGAAGCCGAGACCCACAGCTATGCCGCCACGGCCCTTTGGGGAAATGC
GTGCACTGCGTCCCTCTAGAGCCATTCGATGAGGACTATCTAAACCATCTCGAGCCTCCCGTGAAGCACATGTCCTTCCACGCCTACATC
CGGAAGCTGACTGGAGGGGCTGACAAGGGGAAGTTTGTTGCCCTGGAGAACATCAGCTGCAAGATTAAGTCAGGGTGCGAGGGGCACCTC
CCGTGGCCGAATGGCATCTGTACTAAGTGCCAGCCGAGCGCCATCACGCTGAACAGACAGAAGTACAGGCATGTGGACAATATCATGTTT
GAGAATCACACCGTCGCTGACCGCTTTCTTGACTTCTGGAGAAAGACAGGGAACCAGCATTTTGGGTACTTATACGGACGGTACACGGAG
CACAAAGACATTCCCCTTGGCATCAGGGCTGAAGTGGCTGCGATTTATGAGCCACCTCAGATTGGTACACAGAACAGCTTGGAGCTTCTT
GAGGATCCAAAAGCTGAAGTGGTCGATGAAATTGCTGCCAAACTTGGCCTGCGGAAGCCAAAACAACTTCCCGACAAGTGGCAGCACGAT
CTTTTCGACAGTGGCTTCGGCGGTGGTGCCGGCGTGGAGACAGGTGGGAAACTGCTGGTGTCCAATCTGGATTTTGGAGTCTCAGACGCC
GATATTCAGGAACTCTTTGCTGAATTTGGAACGCTGAAGAAGGCGGCTGTGCACTATGATCGCTCTGGTCGCAGCTTAGGAACAGCAGAC
GTGCACTTTGAGCGGAAGGCAGATGCCCTGAAGGCCATGAAGCAGTACAACGGCGTCCCTCTGGATGGCCGCCCCATGAACATTCAGCTT
GTCACGTCACAGATTGACGCACAGCGGAGGCCTGCACAGAGCGTAAACAGAGGTGGCATGACTAGAAACCGTGGCGCTGGAGGTTTTGGT
GGTGGTGGAGGCACCCGGAGAGGCACCCGCGGAGGCGCCCGTGGAAGAGGCAGAGGTGCCGGCAGGAATTCAAAGCAGCAGCTTTCGGCA
GAGGAGCTGGATGCCCAGCTGGACGCCTATAATGCGAGAATGGACACCAGTTAAACAGACCAGCAAATCCGCGTGCGGAACAGGACCCAG
GCGTCTCCTCTTGCTCCCTGGTTGGGGGGCGGTGGCTGGGGCTGTGCGGCCAATGATGGATTTGTTTCTTTTATGTTTTAAAATAGGATT
TAAAAACTCATGTAAAGGTTTTTTTTTTTTCTTTTTTTTTTTTTTTAATTCTGAAACAGACCTGTTTTGTACCGAGTTATTTTTGGGATA

>59941_59941_2_NPLOC4-ALYREF_NPLOC4_chr17_79567367_ENST00000331134_ALYREF_chr17_79848696_ENST00000505490_length(amino acids)=556AA_BP=20
MVSRPRARGERIERGTGTSAAGGAGRAKLERRWRRRREAGAGAEAAAGSARPLGRQAAAARGSSPEAGAAAMAESIIIRVQSPDGVKRIT
ATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASSNKSLNLLKIKHGDLLFLFPSSLAGPSSEMETSVPPGFKVFGAPNVVEDE
IDQYLSKQDGKIYRSRDPQLCRHGPLGKCVHCVPLEPFDEDYLNHLEPPVKHMSFHAYIRKLTGGADKGKFVALENISCKIKSGCEGHLP
WPNGICTKCQPSAITLNRQKYRHVDNIMFENHTVADRFLDFWRKTGNQHFGYLYGRYTEHKDIPLGIRAEVAAIYEPPQIGTQNSLELLE
DPKAEVVDEIAAKLGLRKPKQLPDKWQHDLFDSGFGGGAGVETGGKLLVSNLDFGVSDADIQELFAEFGTLKKAAVHYDRSGRSLGTADV
HFERKADALKAMKQYNGVPLDGRPMNIQLVTSQIDAQRRPAQSVNRGGMTRNRGAGGFGGGGGTRRGTRGGARGRGRGAGRNSKQQLSAE

--------------------------------------------------------------
>59941_59941_3_NPLOC4-ALYREF_NPLOC4_chr17_79567367_ENST00000374747_ALYREF_chr17_79848696_ENST00000331204_length(transcript)=1882nt_BP=1051nt
GCTGGAGCGGCGGTGGCGGCGGCGTAGGGAGGCCGGGGCCGGGGCTGAGGCCGCGGCCGGGTCTGCGAGGCCCTTGGGGCGGCAGGCGGC
GGCGGCCCGGGGCTCGAGCCCGGAGGCAGGAGCAGCCGCCATGGCCGAGAGCATCATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCG
GATCACAGCAACAAAGAGAGAAACAGCAGCAACATTTTTGAAAAAGGTTGCAAAGGAGTTTGGCTTCCAAAATAATGGCTTCTCGGTTTA
CATCAATAGAAACAAGACCGGAGAGATAACAGCCTCCTCCAACAAATCCCTCAACTTGCTAAAAATCAAGCATGGCGATTTGTTGTTCCT
GTTTCCCTCGAGCCTTGCTGGGCCCTCATCTGAAATGGAGACGTCAGTTCCACCGGGCTTCAAAGTCTTTGGCGCTCCCAACGTGGTGGA
GGATGAGATTGATCAGTACCTCAGCAAACAGGACGGGAAGATTTACAGAAGCCGAGACCCACAGCTATGCCGCCACGGCCCTTTGGGGAA
ATGCGTGCACTGCGTCCCTCTAGAGCCATTCGATGAGGACTATCTAAACCATCTCGAGCCTCCCGTGAAGCACATGTCCTTCCACGCCTA
CATCCGGAAGCTGACTGGAGGGGCTGACAAGGGGAAGTTTGTTGCCCTGGAGAACATCAGCTGCAAGATTAAGTCAGGGTGCGAGGGGCA
CCTCCCGTGGCCGAATGGCATCTGTACTAAGTGCCAGCCGAGCGCCATCACGCTGAACAGACAGAAGTACAGGCATGTGGACAATATCAT
GTTTGAGAATCACACCGTCGCTGACCGCTTTCTTGACTTCTGGAGAAAGACAGGGAACCAGCATTTTGGGTACTTATACGGACGGTACAC
GGAGCACAAAGACATTCCCCTTGGCATCAGGGCTGAAGTGGCTGCGATTTATGAGCCACCTCAGATTGGTACACAGAACAGCTTGGAGCT
TCTTGAGGATCCAAAAGCTGAAGTGGTCGATGAAATTGCTGCCAAACTTGGCCTGCGGAAGCCAAAACAACTTCCCGACAAGTGGCAGCA
CGATCTTTTCGACAGTGGCTTCGGCGGTGGTGCCGGCGTGGAGACAGGTGGGAAACTGCTGGTGTCCAATCTGGATTTTGGAGTCTCAGA
CGCCGATATTCAGGAACTCTTTGCTGAATTTGGAACGCTGAAGAAGGCGGCTGTGCACTATGATCGCTCTGGTCGCAGCTTAGGAACAGC
AGACGTGCACTTTGAGCGGAAGGCAGATGCCCTGAAGGCCATGAAGCAGTACAACGGCGTCCCTCTGGATGGCCGCCCCATGAACATTCA
GCTTGTCACGTCACAGATTGACGCACAGCGGAGGCCTGCACAGAGCGTAAACAGAGGTGGCATGACTAGAAACCGTGGCGCTGGAGGTTT
TGGTGGTGGTGGAGGCACCCGGAGAGGCACCCGCGGAGGCGCCCGTGGAAGAGGCAGAGGTGCCGGCAGGAATTCAAAGCAGCAGCTTTC
GGCAGAGGAGCTGGATGCCCAGCTGGACGCCTATAATGCGAGAATGGACACCAGTTAAACAGACCAGCAAATCCGCGTGCGGAACAGGAC
CCAGGCGTCTCCTCTTGCTCCCTGGTTGGGGGGCGGTGGCTGGGGCTGTGCGGCCAATGATGGATTTGTTTCTTTTATGTTTTAAAATAG
GATTTAAAAACTCATGTAAAGGTTTTTTTTTTTTCTTTTTTTTTTTTTTTAATTCTGAAACAGACCTGTTTTGTACCGAGTTATTTTTGG

>59941_59941_3_NPLOC4-ALYREF_NPLOC4_chr17_79567367_ENST00000374747_ALYREF_chr17_79848696_ENST00000331204_length(amino acids)=528AA_BP=2
LERRWRRRREAGAGAEAAAGSARPLGRQAAAARGSSPEAGAAAMAESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVY
INRNKTGEITASSNKSLNLLKIKHGDLLFLFPSSLAGPSSEMETSVPPGFKVFGAPNVVEDEIDQYLSKQDGKIYRSRDPQLCRHGPLGK
CVHCVPLEPFDEDYLNHLEPPVKHMSFHAYIRKLTGGADKGKFVALENISCKIKSGCEGHLPWPNGICTKCQPSAITLNRQKYRHVDNIM
FENHTVADRFLDFWRKTGNQHFGYLYGRYTEHKDIPLGIRAEVAAIYEPPQIGTQNSLELLEDPKAEVVDEIAAKLGLRKPKQLPDKWQH
DLFDSGFGGGAGVETGGKLLVSNLDFGVSDADIQELFAEFGTLKKAAVHYDRSGRSLGTADVHFERKADALKAMKQYNGVPLDGRPMNIQ

--------------------------------------------------------------
>59941_59941_4_NPLOC4-ALYREF_NPLOC4_chr17_79567367_ENST00000374747_ALYREF_chr17_79848696_ENST00000505490_length(transcript)=1875nt_BP=1051nt
GCTGGAGCGGCGGTGGCGGCGGCGTAGGGAGGCCGGGGCCGGGGCTGAGGCCGCGGCCGGGTCTGCGAGGCCCTTGGGGCGGCAGGCGGC
GGCGGCCCGGGGCTCGAGCCCGGAGGCAGGAGCAGCCGCCATGGCCGAGAGCATCATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCG
GATCACAGCAACAAAGAGAGAAACAGCAGCAACATTTTTGAAAAAGGTTGCAAAGGAGTTTGGCTTCCAAAATAATGGCTTCTCGGTTTA
CATCAATAGAAACAAGACCGGAGAGATAACAGCCTCCTCCAACAAATCCCTCAACTTGCTAAAAATCAAGCATGGCGATTTGTTGTTCCT
GTTTCCCTCGAGCCTTGCTGGGCCCTCATCTGAAATGGAGACGTCAGTTCCACCGGGCTTCAAAGTCTTTGGCGCTCCCAACGTGGTGGA
GGATGAGATTGATCAGTACCTCAGCAAACAGGACGGGAAGATTTACAGAAGCCGAGACCCACAGCTATGCCGCCACGGCCCTTTGGGGAA
ATGCGTGCACTGCGTCCCTCTAGAGCCATTCGATGAGGACTATCTAAACCATCTCGAGCCTCCCGTGAAGCACATGTCCTTCCACGCCTA
CATCCGGAAGCTGACTGGAGGGGCTGACAAGGGGAAGTTTGTTGCCCTGGAGAACATCAGCTGCAAGATTAAGTCAGGGTGCGAGGGGCA
CCTCCCGTGGCCGAATGGCATCTGTACTAAGTGCCAGCCGAGCGCCATCACGCTGAACAGACAGAAGTACAGGCATGTGGACAATATCAT
GTTTGAGAATCACACCGTCGCTGACCGCTTTCTTGACTTCTGGAGAAAGACAGGGAACCAGCATTTTGGGTACTTATACGGACGGTACAC
GGAGCACAAAGACATTCCCCTTGGCATCAGGGCTGAAGTGGCTGCGATTTATGAGCCACCTCAGATTGGTACACAGAACAGCTTGGAGCT
TCTTGAGGATCCAAAAGCTGAAGTGGTCGATGAAATTGCTGCCAAACTTGGCCTGCGGAAGCCAAAACAACTTCCCGACAAGTGGCAGCA
CGATCTTTTCGACAGTGGCTTCGGCGGTGGTGCCGGCGTGGAGACAGGTGGGAAACTGCTGGTGTCCAATCTGGATTTTGGAGTCTCAGA
CGCCGATATTCAGGAACTCTTTGCTGAATTTGGAACGCTGAAGAAGGCGGCTGTGCACTATGATCGCTCTGGTCGCAGCTTAGGAACAGC
AGACGTGCACTTTGAGCGGAAGGCAGATGCCCTGAAGGCCATGAAGCAGTACAACGGCGTCCCTCTGGATGGCCGCCCCATGAACATTCA
GCTTGTCACGTCACAGATTGACGCACAGCGGAGGCCTGCACAGAGCGTAAACAGAGGTGGCATGACTAGAAACCGTGGCGCTGGAGGTTT
TGGTGGTGGTGGAGGCACCCGGAGAGGCACCCGCGGAGGCGCCCGTGGAAGAGGCAGAGGTGCCGGCAGGAATTCAAAGCAGCAGCTTTC
GGCAGAGGAGCTGGATGCCCAGCTGGACGCCTATAATGCGAGAATGGACACCAGTTAAACAGACCAGCAAATCCGCGTGCGGAACAGGAC
CCAGGCGTCTCCTCTTGCTCCCTGGTTGGGGGGCGGTGGCTGGGGCTGTGCGGCCAATGATGGATTTGTTTCTTTTATGTTTTAAAATAG
GATTTAAAAACTCATGTAAAGGTTTTTTTTTTTTCTTTTTTTTTTTTTTTAATTCTGAAACAGACCTGTTTTGTACCGAGTTATTTTTGG

>59941_59941_4_NPLOC4-ALYREF_NPLOC4_chr17_79567367_ENST00000374747_ALYREF_chr17_79848696_ENST00000505490_length(amino acids)=528AA_BP=2
LERRWRRRREAGAGAEAAAGSARPLGRQAAAARGSSPEAGAAAMAESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVY
INRNKTGEITASSNKSLNLLKIKHGDLLFLFPSSLAGPSSEMETSVPPGFKVFGAPNVVEDEIDQYLSKQDGKIYRSRDPQLCRHGPLGK
CVHCVPLEPFDEDYLNHLEPPVKHMSFHAYIRKLTGGADKGKFVALENISCKIKSGCEGHLPWPNGICTKCQPSAITLNRQKYRHVDNIM
FENHTVADRFLDFWRKTGNQHFGYLYGRYTEHKDIPLGIRAEVAAIYEPPQIGTQNSLELLEDPKAEVVDEIAAKLGLRKPKQLPDKWQH
DLFDSGFGGGAGVETGGKLLVSNLDFGVSDADIQELFAEFGTLKKAAVHYDRSGRSLGTADVHFERKADALKAMKQYNGVPLDGRPMNIQ

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NPLOC4-ALYREF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneALYREFchr17:79567367chr17:79848696ENST000003312040685_18679.0258.0HHV-8 ORF57 protein and with ICP27 from HHV-1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for NPLOC4-ALYREF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for NPLOC4-ALYREF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource