Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NPLOC4-SGPL1 (FusionGDB2 ID:59958)

Fusion Gene Summary for NPLOC4-SGPL1

Fusion gene summary

Fusion gene information	Fusion gene name: NPLOC4-SGPL1
	Fusion gene ID: 59958
		Hgene	Tgene
	Gene symbol	NPLOC4	SGPL1
	Gene ID	55666	8879
	Gene name	NPL4 homolog, ubiquitin recognition factor	sphingosine-1-phosphate lyase 1
	Synonyms	NPL4	NPHS14\|S1PL\|SPL
	Cytomap	17q25.3	10q22.1
	Type of gene	protein-coding	protein-coding
	Description	nuclear protein localization protein 4 homologNPLOC4 ubiquitin recognition factornuclear protein localization 4 homolog	sphingosine-1-phosphate lyase 1SP-lyase 1SPL 1hSPLsphingosine-1-phosphate aldolase
	Modification date	20200313	20200313
	UniProtAcc	Q8TAT6	.
	Ensembl transtripts involved in fusion gene	ENST00000331134, ENST00000374747, ENST00000574344, ENST00000539314, ENST00000572760, ENST00000573876,	ENST00000486993, ENST00000373202,
Fusion gene scores	* DoF score	19 X 17 X 11=3553	5 X 5 X 4=100
	# samples	30	5
	** MAII score	log2(30/3553*10)=-3.56600328283534 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NPLOC4 [Title/Abstract] AND SGPL1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NPLOC4(79577236)-SGPL1(72630805), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SGPL1	GO:0006631	fatty acid metabolic process	24809814
Tgene	SGPL1	GO:0006672	ceramide metabolic process	14570870
Tgene	SGPL1	GO:0030149	sphingolipid catabolic process	24809814
Tgene	SGPL1	GO:0097190	apoptotic signaling pathway	14570870

Fusion gene breakpoints across NPLOC4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SGPL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-D7-A4Z0-01A	NPLOC4	chr17	79577236	-	SGPL1	chr10	72630805	+

Top

Fusion Gene ORF analysis for NPLOC4-SGPL1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000331134	ENST00000486993	NPLOC4	chr17	79577236	-	SGPL1	chr10	72630805	+
5CDS-intron	ENST00000374747	ENST00000486993	NPLOC4	chr17	79577236	-	SGPL1	chr10	72630805	+
5UTR-3CDS	ENST00000574344	ENST00000373202	NPLOC4	chr17	79577236	-	SGPL1	chr10	72630805	+
5UTR-intron	ENST00000574344	ENST00000486993	NPLOC4	chr17	79577236	-	SGPL1	chr10	72630805	+
In-frame	ENST00000331134	ENST00000373202	NPLOC4	chr17	79577236	-	SGPL1	chr10	72630805	+
In-frame	ENST00000374747	ENST00000373202	NPLOC4	chr17	79577236	-	SGPL1	chr10	72630805	+
intron-3CDS	ENST00000539314	ENST00000373202	NPLOC4	chr17	79577236	-	SGPL1	chr10	72630805	+
intron-3CDS	ENST00000572760	ENST00000373202	NPLOC4	chr17	79577236	-	SGPL1	chr10	72630805	+
intron-3CDS	ENST00000573876	ENST00000373202	NPLOC4	chr17	79577236	-	SGPL1	chr10	72630805	+
intron-intron	ENST00000539314	ENST00000486993	NPLOC4	chr17	79577236	-	SGPL1	chr10	72630805	+
intron-intron	ENST00000572760	ENST00000486993	NPLOC4	chr17	79577236	-	SGPL1	chr10	72630805	+
intron-intron	ENST00000573876	ENST00000486993	NPLOC4	chr17	79577236	-	SGPL1	chr10	72630805	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000331134

NPLOC4

chr17

79577236

ENST00000373202

SGPL1

chr10

72630805

5386

651

1547

514

ENST00000374747

NPLOC4

chr17

79577236

ENST00000373202

SGPL1

chr10

72630805

5300

565

1461

486

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000331134	ENST00000373202	NPLOC4	chr17	79577236	-	SGPL1	chr10	72630805	+	0.001676518	0.9983235
ENST00000374747	ENST00000373202	NPLOC4	chr17	79577236	-	SGPL1	chr10	72630805	+	0.001620867	0.9983791

Top

Fusion Genomic Features for NPLOC4-SGPL1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
NPLOC4	chr17	79577235	-	SGPL1	chr10	72630804	+	0.000768925	0.9992311
NPLOC4	chr17	79577235	-	SGPL1	chr10	72630804	+	0.000768925	0.9992311

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for NPLOC4-SGPL1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:79577236/chr10:72630805)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NPLOC4 Q8TAT6	.
FUNCTION: The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729). {ECO:0000250\|UniProtKB:Q9ES54, ECO:0000269\|PubMed:26471729}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NPLOC4

chr17:79577236

chr10:72630805

ENST00000331134

226_363

145

609.0

Domain

MPN

Hgene

NPLOC4

chr17:79577236

chr10:72630805

ENST00000374747

226_363

145

618.0

Domain

MPN

Hgene

NPLOC4

chr17:79577236

chr10:72630805

ENST00000331134

580_608

145

609.0

Zinc finger

RanBP2-type

Hgene

NPLOC4

chr17:79577236

chr10:72630805

ENST00000374747

580_608

145

618.0

Zinc finger

RanBP2-type

Tgene

SGPL1

chr17:79577236

chr10:72630805

ENST00000373202

1_40

270

569.0

Topological domain

Lumenal

Tgene

SGPL1

chr17:79577236

chr10:72630805

ENST00000373202

62_568

270

569.0

Topological domain

Cytoplasmic

Tgene

SGPL1

chr17:79577236

chr10:72630805

ENST00000373202

41_61

270

569.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Top

Fusion Gene Sequence for NPLOC4-SGPL1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>59958_59958_1_NPLOC4-SGPL1_NPLOC4_chr17_79577236_ENST00000331134_SGPL1_chr10_72630805_ENST00000373202_length(transcript)=5386nt_BP=651nt
AACCTGGTTTCCCGGCCTCGCGCCCGAGGGGAGCGTATTGAGCGAGGCACCGGGACGTCGGCGGCTGGCGGAGCCGGGCGGGCGAAGCTG
GAGCGGCGGTGGCGGCGGCGTAGGGAGGCCGGGGCCGGGGCTGAGGCCGCGGCCGGGTCTGCGAGGCCCTTGGGGCGGCAGGCGGCGGCG
GCCCGGGGCTCGAGCCCGGAGGCAGGAGCAGCCGCCATGGCCGAGAGCATCATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCGGATC
ACAGCAACAAAGAGAGAAACAGCAGCAACATTTTTGAAAAAGGTTGCAAAGGAGTTTGGCTTCCAAAATAATGGCTTCTCGGTTTACATC
AATAGAAACAAGACCGGAGAGATAACAGCCTCCTCCAACAAATCCCTCAACTTGCTAAAAATCAAGCATGGCGATTTGTTGTTCCTGTTT
CCCTCGAGCCTTGCTGGGCCCTCATCTGAAATGGAGACGTCAGTTCCACCGGGCTTCAAAGTCTTTGGCGCTCCCAACGTGGTGGAGGAT
GAGATTGATCAGTACCTCAGCAAACAGGACGGGAAGATTTACAGAAGCCGAGACCCACAGCTATGCCGCCACGGCCCTTTGGGGAAATGC
GTGCACTGCGTCCCTCTAGAGGCAATGAGAAGAGCTATCTCCAGGAACACTGCCATGCTCGTCTGTTCTACCCCACAGTTTCCTCATGGT
GTAATAGATCCTGTCCCTGAAGTGGCCAAGCTGGCTGTCAAATACAAAATACCCCTTCATGTCGACGCTTGTCTGGGAGGCTTCCTCATC
GTCTTTATGGAGAAAGCAGGATACCCACTGGAGCACCCATTTGATTTCCGGGTGAAAGGTGTAACCAGCATTTCAGCTGACACCCATAAG
TATGGCTATGCCCCAAAAGGCTCATCATTGGTGTTGTATAGTGACAAGAAGTACAGGAACTATCAGTTCTTCGTCGATACAGATTGGCAG
GGTGGCATCTATGCTTCCCCAACCATCGCAGGCTCACGGCCTGGTGGCATTAGCGCAGCCTGTTGGGCTGCCTTGATGCACTTCGGTGAG
AACGGCTATGTTGAAGCTACCAAACAGATCATCAAAACTGCTCGCTTCCTCAAGTCAGAACTGGAAAATATCAAAGGCATCTTTGTTTTT
GGGAATCCCCAATTGTCAGTCATTGCTCTGGGATCCCGTGATTTTGACATCTACCGACTATCAAACCTGATGACTGCTAAGGGGTGGAAC
TTGAACCAGTTGCAGTTCCCACCCAGTATTCATTTCTGCATCACATTACTACACGCCCGGAAACGAGTAGCTATACAATTCCTAAAGGAC
ATTCGAGAATCTGTCACTCAAATCATGAAGAATCCTAAAGCGAAGACCACAGGAATGGGTGCCATCTATGGCATGGCCCAGACAACTGTT
GACAGGAATATGGTTGCAGAATTGTCCTCAGTCTTCTTGGACAGCTTGTACAGCACCGACACTGTCACCCAGGGCAGCCAGATGAATGGT
TCTCCAAAACCCCACTGAACTTGGACCCTTTCTAGTCTCAAGGGGATTCCAGCCTTCAGAAGGTTCTTGGGATATGGAACAGGCCGTGCA
CAACTTTGACATCTGGTCTTGCTCCATAGAGCACAACTCAAGATAGACCATGAGACAGCTTGAGCCTCAGGATTCTTGTTCTTCCTCTTA
TCTTCCTTTTGTGGTTTTTAATTTGAAGACCCCAGAGAATTCCATTACATAATGATTTTGCCCTTGTTATAAATGTTACCCTAGGAATTG
TTTTAACCATTTCCTTTTCTAAACTCTCTAGCTTTCAACTTTACTTAAACATTGTGTGGTAGCTCTGACCTGTCCTGATTCTTTAGAGAA
GCTGGGGTACAGTTTATGAGATAGCTAGAGCTTCTTTGTTATCTCAGGCAGGAGGCGTTTACATAACAGATGTTTCCTCAGCTGGGTGTG
AGGTATACTCTAAGCAGGAGGCTTTTTCAGCCTTCTCTCTCTTTTTTTTTTTTTTTTTTTTTTTTGAGATGGAATTTTGCTCTTTTGCCC
AGTCTGGAGTGCAGTGGCATGATCTCAGCTCACTGCAACCTCCACCCACTGGGTTCAAGCGATTCTTCTGCCTCAGCCTCCCGAGTAGCT
GGGATTACCGGCACCCACCACCACGCCTGGCTAATTTTTCAATTTTCTTTTTCAGTAGAGACGGGTTCACCGTGTTGGCCAGGCTGGTCT
TGAACTCCTGACCTCAGGTGATACCCGCCCCCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCTGGCCCTG
TCTCTCTTAAGAGTAGGTTCATTGTCTGTCTTAGAGTCACTTCTATTGCAACTCATTTTCTTTTTCCAGGGCACAGATCGACCAAGCTGC
CGTTCCCTATTCTGCAGGACAGGACTATTCTAGCATACCTGCTTCGTCCACCCAGGCAGGGTTTGGGGTGGTCTCTTCTGTGCCTGCAGT
CCCCATTTGACACTTGGTTGCCACCATCTTTGGAGATTATTGTTTGGAATGATGCTTCCATTGGCTTTTTCTTGTTACCATGGACTAGGA
AGAAAACATGGTTTCCAAATAATCTGGGAGCTTTTGGCCATGGTGCCGCCTTCCTGAATTGGCAGTGGTCAGAGCACACCTGAACCCTAT
CCTGGGCTGGTGATGAGCAGAAATCAGACCTTTTTCTATGCTTTTTTGAATATCAGAGTAGGATGAACACCCAGATTCAAATATGTCACC
AAAGTTGGTGGTGGTCCTTCCCTGCACCCTTGCGTTAAGCCATTATGTAATGAAAATGTGTTTGCTTGAAGGAACAGCTCAAAGCACCTT
CACAAGTTGCCTTGACTTACCCTAGGTGGGTGTGAAAGAGCACCCGTAGCAAGGAAAATTTTCTCTATTAGTGTGTTCTTCTGCCTCTTC
CCCCTTGATTCAGCTTTCAGAGGTACTATGGCAGTTTTGCCTCAGGTGCTGAACATTTCTCAGCCCTGGCTAAAAGGGAGCAGCACAGGG
AGAGAAACAGGATAGGAAAGCAGAATGGCGAGCAGCCTATGGCCCAGGGCCTGTAATCCCTTCCCAAGACTAGCTGCTCAGGGTGGTGCA
GGGACAGGACCAGACCCTGCGCCTATTTCCTGCCTTCTTTCCCCTATAGGGAACTCTGTAGGCTGAGCCACTGTCCTGCTCTTATGACAT
TATATCTTGTGCCTTTCTCCTCAGCAGTGAGCAGTGAGCTACTCCTGGCCCAGGCCCTAGGGGAAATGGATCAGTCTTTGAGGTTTCTAT
TTGGGGAGGGGAGTACTTAAGATGAGTCAAAAGACACTTTCCTCTGTTCCATTCCCCATCTCAGGGACTCCTGAATATTCAGCCTCTCCA
GGCTGGTGTCTTCTAGTTTCCCCCACTGGGAATGCTGGCTGGGAGAGCCATGACTACCAGACTTTTCCTCAGGCTCCTTGGCATGTTAGT
CTGAATTGTTCTTGAGCACTGTACTACTGACCCAACAACTGTGACTAGCTGGCCACGCCATTCAGGGCTGGTGTGGCATTTATGTGTGTG
TGTGTGTGTGTGTGTGTTTTTCCTGTTTGCCCAGCAGTGCATTGTGGGTTCCAAGAGTGGGTAGTGTGTGTATGTGTGTGTGTCAGAGGG
AGACCTGGCAGGCACCTCTTTGAGAGTAGCTGTGGTCAGAGCTGTTTGGTCAGTGCATTATGTTGAATGAGGTCCAGGAACCCAGAGCCA
CCCAGCAGACACCACTGTGGCTTGCCAGCTGCCAAGATGGAGAAGCATGTGCCCCTGTAGAGCGTCTCCCCAGAACCAGACCCCGAGCCA
CTCGCTTCCTCTGTGCTGTGACAACATTGGTGCCAGGGGAGATGGTGTTTTTCAAAGGGACCTACTGTAGCCACTTTAATTTACAATTAA
GAGCCTTAGTTTGACTTAACACTTTTGTAGGCTTTTCATTGTGTATTTTTGTGTATGTGTGCATATAGCAGCTACTCTGTAGCAGAGGTG
GGTAGAGACACTTAATAGTATCATGTCGCATGCAGATGTCACATCGGCCTCTGCAAAAACTGTACTGTCTTGTTTCTGCATTAGACTTAA
GTAGTCATGTGAATATACTGCTATGTCACTTTTAATATTACGAGTTTTATACTTGGAAAATGGTACTTGCTTCTTTTAAATCTCTGTCTT
CTCTAACCTCCCCCTTCCCATTTCAATGCTCCCTTCCTAATTTCAGCAATAATCTCAAAAAGCAATTAAATAGTTAAATGACCCTAATTG
TAATTACTGTGGATGGTTGCATTCATTTGATTACTTGGGCACACACGAGATGACAAATGGGGCAGTGGCCATGCTTGAATGGGCTCCTGG
TGAGAGATTGCCCCCTGGTGGTGAAACAATCGTGTGTGCCCACTGATACCAAGACCAATGAAAGAGACACAGTTAAGCAGCAATCCATCT
CATTTCCAGGCACTTCAATAGGTCGCTGATTGGTCCTTGCACCAGCAGTGGTAGTCGTACCTATTTCAGAGAGGTCTGAAATTCAGGTTC
TTAGTTTGCCAGGGACAGGCCCTATCTTATATTTTTTTCCATCTTCATCATCCACTTCTGCTTACAGTTTGCTGCTTACAATAACTTAAT
GATGGATTGAGTTATCTGGGTGGTCTCTAGCCATCTGGGCAGTGTGGTTCTGTCTAACCAAAGGGCATTGGCCTCAAACCCTGCATTTGG
TTTAGGGGCTAACAGAGCTCCTCAGATAATCTTCACACACATGTAACTGCTGGAGATCTTATTCTATTATGAATAAGAAACGAGAAGTTT
TTCCAAAGTGTTAGTCAGGATCTGAAGGCTGTCATTCAGATAACCCAGCTTTTCCTTTTGGCTTTTAGCCCATTCAGACTTTGCCAGAGT
CAAGCCAAGGATTGCTTTTTTGCTACAGTTTTCTGCCAAATGGCCTAGTTCCTGAGTACCTGGAAACCAGAGAGAAAGAGGATCCAGGAT
GTACTTGGATGAGGAGGCCTGGCTTATCTAGGAAGTCGTGTCTGGGGTGCTTATTGCTGCTCCATACAGCTGTACGTCAGCCCCTTGGCC
TTCTCTGTAGGTTCTTGGCAGCAATGAGCAGCTTTCACTCAGTGACACAAGTAATTACTGAGTCCTAATTTGATAGCCACCAACTGTACC
TGGGTAGGCAAAGTCAGATTTTTGAGAACCTTTTTCCTGATTTGAAGTTTTAATTACCTTATTTTCTTTTATGCTTTCCTCTGTCTTGTA

>59958_59958_1_NPLOC4-SGPL1_NPLOC4_chr17_79577236_ENST00000331134_SGPL1_chr10_72630805_ENST00000373202_length(amino acids)=514AA_BP=216
MVSRPRARGERIERGTGTSAAGGAGRAKLERRWRRRREAGAGAEAAAGSARPLGRQAAAARGSSPEAGAAAMAESIIIRVQSPDGVKRIT
ATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASSNKSLNLLKIKHGDLLFLFPSSLAGPSSEMETSVPPGFKVFGAPNVVEDE
IDQYLSKQDGKIYRSRDPQLCRHGPLGKCVHCVPLEAMRRAISRNTAMLVCSTPQFPHGVIDPVPEVAKLAVKYKIPLHVDACLGGFLIV
FMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKGSSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGEN
GYVEATKQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFPPSIHFCITLLHARKRVAIQFLKDI

--------------------------------------------------------------
>59958_59958_2_NPLOC4-SGPL1_NPLOC4_chr17_79577236_ENST00000374747_SGPL1_chr10_72630805_ENST00000373202_length(transcript)=5300nt_BP=565nt
GCTGGAGCGGCGGTGGCGGCGGCGTAGGGAGGCCGGGGCCGGGGCTGAGGCCGCGGCCGGGTCTGCGAGGCCCTTGGGGCGGCAGGCGGC
GGCGGCCCGGGGCTCGAGCCCGGAGGCAGGAGCAGCCGCCATGGCCGAGAGCATCATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCG
GATCACAGCAACAAAGAGAGAAACAGCAGCAACATTTTTGAAAAAGGTTGCAAAGGAGTTTGGCTTCCAAAATAATGGCTTCTCGGTTTA
CATCAATAGAAACAAGACCGGAGAGATAACAGCCTCCTCCAACAAATCCCTCAACTTGCTAAAAATCAAGCATGGCGATTTGTTGTTCCT
GTTTCCCTCGAGCCTTGCTGGGCCCTCATCTGAAATGGAGACGTCAGTTCCACCGGGCTTCAAAGTCTTTGGCGCTCCCAACGTGGTGGA
GGATGAGATTGATCAGTACCTCAGCAAACAGGACGGGAAGATTTACAGAAGCCGAGACCCACAGCTATGCCGCCACGGCCCTTTGGGGAA
ATGCGTGCACTGCGTCCCTCTAGAGGCAATGAGAAGAGCTATCTCCAGGAACACTGCCATGCTCGTCTGTTCTACCCCACAGTTTCCTCA
TGGTGTAATAGATCCTGTCCCTGAAGTGGCCAAGCTGGCTGTCAAATACAAAATACCCCTTCATGTCGACGCTTGTCTGGGAGGCTTCCT
CATCGTCTTTATGGAGAAAGCAGGATACCCACTGGAGCACCCATTTGATTTCCGGGTGAAAGGTGTAACCAGCATTTCAGCTGACACCCA
TAAGTATGGCTATGCCCCAAAAGGCTCATCATTGGTGTTGTATAGTGACAAGAAGTACAGGAACTATCAGTTCTTCGTCGATACAGATTG
GCAGGGTGGCATCTATGCTTCCCCAACCATCGCAGGCTCACGGCCTGGTGGCATTAGCGCAGCCTGTTGGGCTGCCTTGATGCACTTCGG
TGAGAACGGCTATGTTGAAGCTACCAAACAGATCATCAAAACTGCTCGCTTCCTCAAGTCAGAACTGGAAAATATCAAAGGCATCTTTGT
TTTTGGGAATCCCCAATTGTCAGTCATTGCTCTGGGATCCCGTGATTTTGACATCTACCGACTATCAAACCTGATGACTGCTAAGGGGTG
GAACTTGAACCAGTTGCAGTTCCCACCCAGTATTCATTTCTGCATCACATTACTACACGCCCGGAAACGAGTAGCTATACAATTCCTAAA
GGACATTCGAGAATCTGTCACTCAAATCATGAAGAATCCTAAAGCGAAGACCACAGGAATGGGTGCCATCTATGGCATGGCCCAGACAAC
TGTTGACAGGAATATGGTTGCAGAATTGTCCTCAGTCTTCTTGGACAGCTTGTACAGCACCGACACTGTCACCCAGGGCAGCCAGATGAA
TGGTTCTCCAAAACCCCACTGAACTTGGACCCTTTCTAGTCTCAAGGGGATTCCAGCCTTCAGAAGGTTCTTGGGATATGGAACAGGCCG
TGCACAACTTTGACATCTGGTCTTGCTCCATAGAGCACAACTCAAGATAGACCATGAGACAGCTTGAGCCTCAGGATTCTTGTTCTTCCT
CTTATCTTCCTTTTGTGGTTTTTAATTTGAAGACCCCAGAGAATTCCATTACATAATGATTTTGCCCTTGTTATAAATGTTACCCTAGGA
ATTGTTTTAACCATTTCCTTTTCTAAACTCTCTAGCTTTCAACTTTACTTAAACATTGTGTGGTAGCTCTGACCTGTCCTGATTCTTTAG
AGAAGCTGGGGTACAGTTTATGAGATAGCTAGAGCTTCTTTGTTATCTCAGGCAGGAGGCGTTTACATAACAGATGTTTCCTCAGCTGGG
TGTGAGGTATACTCTAAGCAGGAGGCTTTTTCAGCCTTCTCTCTCTTTTTTTTTTTTTTTTTTTTTTTTGAGATGGAATTTTGCTCTTTT
GCCCAGTCTGGAGTGCAGTGGCATGATCTCAGCTCACTGCAACCTCCACCCACTGGGTTCAAGCGATTCTTCTGCCTCAGCCTCCCGAGT
AGCTGGGATTACCGGCACCCACCACCACGCCTGGCTAATTTTTCAATTTTCTTTTTCAGTAGAGACGGGTTCACCGTGTTGGCCAGGCTG
GTCTTGAACTCCTGACCTCAGGTGATACCCGCCCCCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCTGGC
CCTGTCTCTCTTAAGAGTAGGTTCATTGTCTGTCTTAGAGTCACTTCTATTGCAACTCATTTTCTTTTTCCAGGGCACAGATCGACCAAG
CTGCCGTTCCCTATTCTGCAGGACAGGACTATTCTAGCATACCTGCTTCGTCCACCCAGGCAGGGTTTGGGGTGGTCTCTTCTGTGCCTG
CAGTCCCCATTTGACACTTGGTTGCCACCATCTTTGGAGATTATTGTTTGGAATGATGCTTCCATTGGCTTTTTCTTGTTACCATGGACT
AGGAAGAAAACATGGTTTCCAAATAATCTGGGAGCTTTTGGCCATGGTGCCGCCTTCCTGAATTGGCAGTGGTCAGAGCACACCTGAACC
CTATCCTGGGCTGGTGATGAGCAGAAATCAGACCTTTTTCTATGCTTTTTTGAATATCAGAGTAGGATGAACACCCAGATTCAAATATGT
CACCAAAGTTGGTGGTGGTCCTTCCCTGCACCCTTGCGTTAAGCCATTATGTAATGAAAATGTGTTTGCTTGAAGGAACAGCTCAAAGCA
CCTTCACAAGTTGCCTTGACTTACCCTAGGTGGGTGTGAAAGAGCACCCGTAGCAAGGAAAATTTTCTCTATTAGTGTGTTCTTCTGCCT
CTTCCCCCTTGATTCAGCTTTCAGAGGTACTATGGCAGTTTTGCCTCAGGTGCTGAACATTTCTCAGCCCTGGCTAAAAGGGAGCAGCAC
AGGGAGAGAAACAGGATAGGAAAGCAGAATGGCGAGCAGCCTATGGCCCAGGGCCTGTAATCCCTTCCCAAGACTAGCTGCTCAGGGTGG
TGCAGGGACAGGACCAGACCCTGCGCCTATTTCCTGCCTTCTTTCCCCTATAGGGAACTCTGTAGGCTGAGCCACTGTCCTGCTCTTATG
ACATTATATCTTGTGCCTTTCTCCTCAGCAGTGAGCAGTGAGCTACTCCTGGCCCAGGCCCTAGGGGAAATGGATCAGTCTTTGAGGTTT
CTATTTGGGGAGGGGAGTACTTAAGATGAGTCAAAAGACACTTTCCTCTGTTCCATTCCCCATCTCAGGGACTCCTGAATATTCAGCCTC
TCCAGGCTGGTGTCTTCTAGTTTCCCCCACTGGGAATGCTGGCTGGGAGAGCCATGACTACCAGACTTTTCCTCAGGCTCCTTGGCATGT
TAGTCTGAATTGTTCTTGAGCACTGTACTACTGACCCAACAACTGTGACTAGCTGGCCACGCCATTCAGGGCTGGTGTGGCATTTATGTG
TGTGTGTGTGTGTGTGTGTGTTTTTCCTGTTTGCCCAGCAGTGCATTGTGGGTTCCAAGAGTGGGTAGTGTGTGTATGTGTGTGTGTCAG
AGGGAGACCTGGCAGGCACCTCTTTGAGAGTAGCTGTGGTCAGAGCTGTTTGGTCAGTGCATTATGTTGAATGAGGTCCAGGAACCCAGA
GCCACCCAGCAGACACCACTGTGGCTTGCCAGCTGCCAAGATGGAGAAGCATGTGCCCCTGTAGAGCGTCTCCCCAGAACCAGACCCCGA
GCCACTCGCTTCCTCTGTGCTGTGACAACATTGGTGCCAGGGGAGATGGTGTTTTTCAAAGGGACCTACTGTAGCCACTTTAATTTACAA
TTAAGAGCCTTAGTTTGACTTAACACTTTTGTAGGCTTTTCATTGTGTATTTTTGTGTATGTGTGCATATAGCAGCTACTCTGTAGCAGA
GGTGGGTAGAGACACTTAATAGTATCATGTCGCATGCAGATGTCACATCGGCCTCTGCAAAAACTGTACTGTCTTGTTTCTGCATTAGAC
TTAAGTAGTCATGTGAATATACTGCTATGTCACTTTTAATATTACGAGTTTTATACTTGGAAAATGGTACTTGCTTCTTTTAAATCTCTG
TCTTCTCTAACCTCCCCCTTCCCATTTCAATGCTCCCTTCCTAATTTCAGCAATAATCTCAAAAAGCAATTAAATAGTTAAATGACCCTA
ATTGTAATTACTGTGGATGGTTGCATTCATTTGATTACTTGGGCACACACGAGATGACAAATGGGGCAGTGGCCATGCTTGAATGGGCTC
CTGGTGAGAGATTGCCCCCTGGTGGTGAAACAATCGTGTGTGCCCACTGATACCAAGACCAATGAAAGAGACACAGTTAAGCAGCAATCC
ATCTCATTTCCAGGCACTTCAATAGGTCGCTGATTGGTCCTTGCACCAGCAGTGGTAGTCGTACCTATTTCAGAGAGGTCTGAAATTCAG
GTTCTTAGTTTGCCAGGGACAGGCCCTATCTTATATTTTTTTCCATCTTCATCATCCACTTCTGCTTACAGTTTGCTGCTTACAATAACT
TAATGATGGATTGAGTTATCTGGGTGGTCTCTAGCCATCTGGGCAGTGTGGTTCTGTCTAACCAAAGGGCATTGGCCTCAAACCCTGCAT
TTGGTTTAGGGGCTAACAGAGCTCCTCAGATAATCTTCACACACATGTAACTGCTGGAGATCTTATTCTATTATGAATAAGAAACGAGAA
GTTTTTCCAAAGTGTTAGTCAGGATCTGAAGGCTGTCATTCAGATAACCCAGCTTTTCCTTTTGGCTTTTAGCCCATTCAGACTTTGCCA
GAGTCAAGCCAAGGATTGCTTTTTTGCTACAGTTTTCTGCCAAATGGCCTAGTTCCTGAGTACCTGGAAACCAGAGAGAAAGAGGATCCA
GGATGTACTTGGATGAGGAGGCCTGGCTTATCTAGGAAGTCGTGTCTGGGGTGCTTATTGCTGCTCCATACAGCTGTACGTCAGCCCCTT
GGCCTTCTCTGTAGGTTCTTGGCAGCAATGAGCAGCTTTCACTCAGTGACACAAGTAATTACTGAGTCCTAATTTGATAGCCACCAACTG
TACCTGGGTAGGCAAAGTCAGATTTTTGAGAACCTTTTTCCTGATTTGAAGTTTTAATTACCTTATTTTCTTTTATGCTTTCCTCTGTCT

>59958_59958_2_NPLOC4-SGPL1_NPLOC4_chr17_79577236_ENST00000374747_SGPL1_chr10_72630805_ENST00000373202_length(amino acids)=486AA_BP=188
LERRWRRRREAGAGAEAAAGSARPLGRQAAAARGSSPEAGAAAMAESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVY
INRNKTGEITASSNKSLNLLKIKHGDLLFLFPSSLAGPSSEMETSVPPGFKVFGAPNVVEDEIDQYLSKQDGKIYRSRDPQLCRHGPLGK
CVHCVPLEAMRRAISRNTAMLVCSTPQFPHGVIDPVPEVAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTH
KYGYAPKGSSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKGIFV
FGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFPPSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NPLOC4-SGPL1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for NPLOC4-SGPL1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for NPLOC4-SGPL1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source