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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:A1CF-ANKDD1A (FusionGDB2 ID:6)

Fusion Gene Summary for A1CF-ANKDD1A

check button Fusion gene summary
Fusion gene informationFusion gene name: A1CF-ANKDD1A
Fusion gene ID: 6
HgeneTgene
Gene symbol

A1CF

ANKDD1A

Gene ID

29974

348094

Gene nameAPOBEC1 complementation factorankyrin repeat and death domain containing 1A
SynonymsACF|ACF64|ACF65|APOBEC1CF|ASP-
Cytomap

10q11.23

15q22.31

Type of geneprotein-codingprotein-coding
DescriptionAPOBEC1 complementation factorAPOBEC-1 stimulating proteinapo-B RNA editing proteinapobec-1 complementation factor (ACF) (ASP)ankyrin repeat and death domain-containing protein 1A
Modification date2020031320200313
UniProtAcc

Q9NQ94

Q495B1

Ensembl transtripts involved in fusion geneENST00000282641, ENST00000373993, 
ENST00000373995, ENST00000373997, 
ENST00000374001, ENST00000395489, 
ENST00000395495, ENST00000493415, 
ENST00000319580, ENST00000357698, 
ENST00000380230, ENST00000395720, 
ENST00000395723, ENST00000491145, 
ENST00000496660, 
Fusion gene scores* DoF score2 X 2 X 1=420 X 20 X 6=2400
# samples 223
** MAII scorelog2(2/4*10)=2.32192809488736log2(23/2400*10)=-3.38332863955151
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: A1CF [Title/Abstract] AND ANKDD1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointA1CF(52595988)-ANKDD1A(65245493), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneA1CF

GO:0050821

protein stabilization

12881431


check buttonFusion gene breakpoints across A1CF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ANKDD1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABC022263A1CFchr10

52595988

-ANKDD1Achr15

65245493

-


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Fusion Gene ORF analysis for A1CF-ANKDD1A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000282641ENST00000319580A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000282641ENST00000357698A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000282641ENST00000380230A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000282641ENST00000395720A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000282641ENST00000395723A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000282641ENST00000491145A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000282641ENST00000496660A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000373993ENST00000319580A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000373993ENST00000357698A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000373993ENST00000380230A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000373993ENST00000395720A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000373993ENST00000395723A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000373993ENST00000491145A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000373993ENST00000496660A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000373995ENST00000319580A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000373995ENST00000357698A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000373995ENST00000380230A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000373995ENST00000395720A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000373995ENST00000395723A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000373995ENST00000491145A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000373995ENST00000496660A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000373997ENST00000319580A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000373997ENST00000357698A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000373997ENST00000380230A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000373997ENST00000395720A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000373997ENST00000395723A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000373997ENST00000491145A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000373997ENST00000496660A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000374001ENST00000319580A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000374001ENST00000357698A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000374001ENST00000380230A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000374001ENST00000395720A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000374001ENST00000395723A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000374001ENST00000491145A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000374001ENST00000496660A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000395489ENST00000319580A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000395489ENST00000357698A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000395489ENST00000380230A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000395489ENST00000395720A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000395489ENST00000395723A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000395489ENST00000491145A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000395489ENST00000496660A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000395495ENST00000319580A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000395495ENST00000357698A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000395495ENST00000380230A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000395495ENST00000395720A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000395495ENST00000395723A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000395495ENST00000491145A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000395495ENST00000496660A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000493415ENST00000319580A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000493415ENST00000357698A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000493415ENST00000380230A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000493415ENST00000395720A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000493415ENST00000395723A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000493415ENST00000491145A1CFchr10

52595988

-ANKDD1Achr15

65245493

-
intron-intronENST00000493415ENST00000496660A1CFchr10

52595988

-ANKDD1Achr15

65245493

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for A1CF-ANKDD1A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for A1CF-ANKDD1A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:52595988/:65245493)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
A1CF

Q9NQ94

ANKDD1A

Q495B1

FUNCTION: Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay. {ECO:0000269|PubMed:10669759, ECO:0000269|PubMed:10781591, ECO:0000269|PubMed:12881431}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for A1CF-ANKDD1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for A1CF-ANKDD1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for A1CF-ANKDD1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for A1CF-ANKDD1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource