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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NPSR1-C7orf10 (FusionGDB2 ID:60019)

Fusion Gene Summary for NPSR1-C7orf10

check button Fusion gene summary
Fusion gene informationFusion gene name: NPSR1-C7orf10
Fusion gene ID: 60019
HgeneTgene
Gene symbol

NPSR1

C7orf10

Gene ID

387129

79783

Gene nameneuropeptide S receptor 1succinyl-CoA:glutarate-CoA transferase
SynonymsASRT2|GPR154|GPRA|NPSR|PGR14|VRR1C7orf10|DERP13|GA3|ORF19
Cytomap

7p14.3

7p14.1

Type of geneprotein-codingprotein-coding
Descriptionneuropeptide S receptorG-protein coupled receptor 154G-protein coupled receptor PGR14G-protein coupled receptor for asthma susceptibilityvasopressin receptor-related receptor 1succinate--hydroxymethylglutarate CoA-transferaseRussel-Silver syndrome candidatedermal papilla-derived protein 13succinylCoA:glutarate-CoA transferase
Modification date2020032220200313
UniProtAcc

Q6W5P4

.
Ensembl transtripts involved in fusion geneENST00000359791, ENST00000360581, 
ENST00000381539, ENST00000381542, 
ENST00000381553, ENST00000465305, 
ENST00000531252, 		ENST00000464028, 
ENST00000540834, ENST00000335693, 
ENST00000401647, ENST00000309930, 
Fusion gene scores* DoF score3 X 3 X 3=2713 X 14 X 14=2548
# samples 324
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(24/2548*10)=-3.40825896664778
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NPSR1 [Title/Abstract] AND C7orf10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNPSR1(34698171)-C7orf10(40899915), # samples:1
Anticipated loss of major functional domain due to fusion event.NPSR1-C7orf10 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNPSR1

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

16790440


check buttonFusion gene breakpoints across NPSR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across C7orf10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-7959-01ANPSR1chr7

34698171

-C7orf10chr7

40899915

+


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Fusion Gene ORF analysis for NPSR1-C7orf10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000359791ENST00000464028NPSR1chr7

34698171

-C7orf10chr7

40899915

+
5CDS-3UTRENST00000360581ENST00000464028NPSR1chr7

34698171

-C7orf10chr7

40899915

+
5CDS-3UTRENST00000381539ENST00000464028NPSR1chr7

34698171

-C7orf10chr7

40899915

+
5CDS-3UTRENST00000381542ENST00000464028NPSR1chr7

34698171

-C7orf10chr7

40899915

+
5CDS-3UTRENST00000381553ENST00000464028NPSR1chr7

34698171

-C7orf10chr7

40899915

+
5CDS-3UTRENST00000465305ENST00000464028NPSR1chr7

34698171

-C7orf10chr7

40899915

+
5CDS-3UTRENST00000531252ENST00000464028NPSR1chr7

34698171

-C7orf10chr7

40899915

+
5CDS-intronENST00000359791ENST00000540834NPSR1chr7

34698171

-C7orf10chr7

40899915

+
5CDS-intronENST00000360581ENST00000540834NPSR1chr7

34698171

-C7orf10chr7

40899915

+
5CDS-intronENST00000381539ENST00000540834NPSR1chr7

34698171

-C7orf10chr7

40899915

+
5CDS-intronENST00000381542ENST00000540834NPSR1chr7

34698171

-C7orf10chr7

40899915

+
5CDS-intronENST00000381553ENST00000540834NPSR1chr7

34698171

-C7orf10chr7

40899915

+
5CDS-intronENST00000465305ENST00000540834NPSR1chr7

34698171

-C7orf10chr7

40899915

+
5CDS-intronENST00000531252ENST00000540834NPSR1chr7

34698171

-C7orf10chr7

40899915

+
Frame-shiftENST00000359791ENST00000335693NPSR1chr7

34698171

-C7orf10chr7

40899915

+
Frame-shiftENST00000359791ENST00000401647NPSR1chr7

34698171

-C7orf10chr7

40899915

+
Frame-shiftENST00000360581ENST00000335693NPSR1chr7

34698171

-C7orf10chr7

40899915

+
Frame-shiftENST00000360581ENST00000401647NPSR1chr7

34698171

-C7orf10chr7

40899915

+
Frame-shiftENST00000381539ENST00000335693NPSR1chr7

34698171

-C7orf10chr7

40899915

+
Frame-shiftENST00000381539ENST00000401647NPSR1chr7

34698171

-C7orf10chr7

40899915

+
Frame-shiftENST00000381542ENST00000335693NPSR1chr7

34698171

-C7orf10chr7

40899915

+
Frame-shiftENST00000381542ENST00000401647NPSR1chr7

34698171

-C7orf10chr7

40899915

+
Frame-shiftENST00000381553ENST00000335693NPSR1chr7

34698171

-C7orf10chr7

40899915

+
Frame-shiftENST00000381553ENST00000401647NPSR1chr7

34698171

-C7orf10chr7

40899915

+
Frame-shiftENST00000465305ENST00000335693NPSR1chr7

34698171

-C7orf10chr7

40899915

+
Frame-shiftENST00000465305ENST00000401647NPSR1chr7

34698171

-C7orf10chr7

40899915

+
Frame-shiftENST00000531252ENST00000335693NPSR1chr7

34698171

-C7orf10chr7

40899915

+
Frame-shiftENST00000531252ENST00000401647NPSR1chr7

34698171

-C7orf10chr7

40899915

+
In-frameENST00000359791ENST00000309930NPSR1chr7

34698171

-C7orf10chr7

40899915

+
In-frameENST00000360581ENST00000309930NPSR1chr7

34698171

-C7orf10chr7

40899915

+
In-frameENST00000381539ENST00000309930NPSR1chr7

34698171

-C7orf10chr7

40899915

+
In-frameENST00000381542ENST00000309930NPSR1chr7

34698171

-C7orf10chr7

40899915

+
In-frameENST00000381553ENST00000309930NPSR1chr7

34698171

-C7orf10chr7

40899915

+
In-frameENST00000465305ENST00000309930NPSR1chr7

34698171

-C7orf10chr7

40899915

+
In-frameENST00000531252ENST00000309930NPSR1chr7

34698171

-C7orf10chr7

40899915

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000381553NPSR1chr734698171-ENST00000309930C7orf10chr740899915+76432154476273
ENST00000381542NPSR1chr734698171-ENST00000309930C7orf10chr740899915+71827549871673
ENST00000360581NPSR1chr734698171-ENST00000309930C7orf10chr740899915+71827549871673
ENST00000359791NPSR1chr734698171-ENST00000309930C7orf10chr740899915+71827549871673
ENST00000531252NPSR1chr734698171-ENST00000309930C7orf10chr740899915+71827549871673
ENST00000381539NPSR1chr734698171-ENST00000309930C7orf10chr740899915+59415137459273
ENST00000465305NPSR1chr734698171-ENST00000309930C7orf10chr740899915+71827549871673

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000381553ENST00000309930NPSR1chr734698171-C7orf10chr740899915+0.83875350.16124651
ENST00000381542ENST00000309930NPSR1chr734698171-C7orf10chr740899915+0.86025280.1397472
ENST00000360581ENST00000309930NPSR1chr734698171-C7orf10chr740899915+0.86025280.1397472
ENST00000359791ENST00000309930NPSR1chr734698171-C7orf10chr740899915+0.86025280.1397472
ENST00000531252ENST00000309930NPSR1chr734698171-C7orf10chr740899915+0.86025280.1397472
ENST00000381539ENST00000309930NPSR1chr734698171-C7orf10chr740899915+0.884957430.11504259
ENST00000465305ENST00000309930NPSR1chr734698171-C7orf10chr740899915+0.86025280.1397472

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Fusion Genomic Features for NPSR1-C7orf10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NPSR1-C7orf10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:34698171/chr7:40899915)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NPSR1

Q6W5P4

.
FUNCTION: G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases. {ECO:0000269|PubMed:15312648, ECO:0000269|PubMed:15947423, ECO:0000269|PubMed:16790440}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNPSR1chr7:34698171chr7:40899915ENST00000359791-191_5249378.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000360581-191_5249372.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381539-1101_5249391.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381542-171_5249306.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381553-141_5249144.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000465305-131_524995.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000531252-191_5249367.0Topological domainExtracellular

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNPSR1chr7:34698171chr7:40899915ENST00000359791-19104_12349378.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000359791-19145_16449378.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000359791-19186_21249378.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000359791-19234_27549378.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000359791-19297_31249378.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000359791-19334_37149378.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000359791-1974_8249378.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000360581-19104_12349372.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000360581-19145_16449372.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000360581-19186_21249372.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000360581-19234_27549372.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000360581-19297_31249372.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000360581-19334_37149372.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000360581-1974_8249372.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381539-110104_12349391.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381539-110145_16449391.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381539-110186_21249391.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381539-110234_27549391.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381539-110297_31249391.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381539-110334_37149391.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381539-11074_8249391.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381542-17104_12349306.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381542-17145_16449306.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381542-17186_21249306.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381542-17234_27549306.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381542-17297_31249306.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381542-17334_37149306.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381542-1774_8249306.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381553-14104_12349144.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381553-14145_16449144.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381553-14186_21249144.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381553-14234_27549144.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381553-14297_31249144.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381553-14334_37149144.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381553-1474_8249144.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000465305-13104_1234995.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000465305-13145_1644995.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000465305-13186_2124995.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000465305-13234_2754995.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000465305-13297_3124995.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000465305-13334_3714995.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000465305-1374_824995.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000531252-19104_12349367.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000531252-19145_16449367.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000531252-19186_21249367.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000531252-19234_27549367.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000531252-19297_31249367.0Topological domainExtracellular
HgeneNPSR1chr7:34698171chr7:40899915ENST00000531252-19334_37149367.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000531252-1974_8249367.0Topological domainCytoplasmic
HgeneNPSR1chr7:34698171chr7:40899915ENST00000359791-19124_14449378.0TransmembraneHelical%3B Name%3D3
HgeneNPSR1chr7:34698171chr7:40899915ENST00000359791-19165_18549378.0TransmembraneHelical%3B Name%3D4
HgeneNPSR1chr7:34698171chr7:40899915ENST00000359791-19213_23349378.0TransmembraneHelical%3B Name%3D5
HgeneNPSR1chr7:34698171chr7:40899915ENST00000359791-19276_29649378.0TransmembraneHelical%3B Name%3D6
HgeneNPSR1chr7:34698171chr7:40899915ENST00000359791-19313_33349378.0TransmembraneHelical%3B Name%3D7
HgeneNPSR1chr7:34698171chr7:40899915ENST00000359791-1953_7349378.0TransmembraneHelical%3B Name%3D1
HgeneNPSR1chr7:34698171chr7:40899915ENST00000359791-1983_10349378.0TransmembraneHelical%3B Name%3D2
HgeneNPSR1chr7:34698171chr7:40899915ENST00000360581-19124_14449372.0TransmembraneHelical%3B Name%3D3
HgeneNPSR1chr7:34698171chr7:40899915ENST00000360581-19165_18549372.0TransmembraneHelical%3B Name%3D4
HgeneNPSR1chr7:34698171chr7:40899915ENST00000360581-19213_23349372.0TransmembraneHelical%3B Name%3D5
HgeneNPSR1chr7:34698171chr7:40899915ENST00000360581-19276_29649372.0TransmembraneHelical%3B Name%3D6
HgeneNPSR1chr7:34698171chr7:40899915ENST00000360581-19313_33349372.0TransmembraneHelical%3B Name%3D7
HgeneNPSR1chr7:34698171chr7:40899915ENST00000360581-1953_7349372.0TransmembraneHelical%3B Name%3D1
HgeneNPSR1chr7:34698171chr7:40899915ENST00000360581-1983_10349372.0TransmembraneHelical%3B Name%3D2
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381539-110124_14449391.0TransmembraneHelical%3B Name%3D3
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381539-110165_18549391.0TransmembraneHelical%3B Name%3D4
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381539-110213_23349391.0TransmembraneHelical%3B Name%3D5
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381539-110276_29649391.0TransmembraneHelical%3B Name%3D6
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381539-110313_33349391.0TransmembraneHelical%3B Name%3D7
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381539-11053_7349391.0TransmembraneHelical%3B Name%3D1
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381539-11083_10349391.0TransmembraneHelical%3B Name%3D2
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381542-17124_14449306.0TransmembraneHelical%3B Name%3D3
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381542-17165_18549306.0TransmembraneHelical%3B Name%3D4
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381542-17213_23349306.0TransmembraneHelical%3B Name%3D5
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381542-17276_29649306.0TransmembraneHelical%3B Name%3D6
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381542-17313_33349306.0TransmembraneHelical%3B Name%3D7
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381542-1753_7349306.0TransmembraneHelical%3B Name%3D1
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381542-1783_10349306.0TransmembraneHelical%3B Name%3D2
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381553-14124_14449144.0TransmembraneHelical%3B Name%3D3
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381553-14165_18549144.0TransmembraneHelical%3B Name%3D4
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381553-14213_23349144.0TransmembraneHelical%3B Name%3D5
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381553-14276_29649144.0TransmembraneHelical%3B Name%3D6
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381553-14313_33349144.0TransmembraneHelical%3B Name%3D7
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381553-1453_7349144.0TransmembraneHelical%3B Name%3D1
HgeneNPSR1chr7:34698171chr7:40899915ENST00000381553-1483_10349144.0TransmembraneHelical%3B Name%3D2
HgeneNPSR1chr7:34698171chr7:40899915ENST00000465305-13124_1444995.0TransmembraneHelical%3B Name%3D3
HgeneNPSR1chr7:34698171chr7:40899915ENST00000465305-13165_1854995.0TransmembraneHelical%3B Name%3D4
HgeneNPSR1chr7:34698171chr7:40899915ENST00000465305-13213_2334995.0TransmembraneHelical%3B Name%3D5
HgeneNPSR1chr7:34698171chr7:40899915ENST00000465305-13276_2964995.0TransmembraneHelical%3B Name%3D6
HgeneNPSR1chr7:34698171chr7:40899915ENST00000465305-13313_3334995.0TransmembraneHelical%3B Name%3D7
HgeneNPSR1chr7:34698171chr7:40899915ENST00000465305-1353_734995.0TransmembraneHelical%3B Name%3D1
HgeneNPSR1chr7:34698171chr7:40899915ENST00000465305-1383_1034995.0TransmembraneHelical%3B Name%3D2
HgeneNPSR1chr7:34698171chr7:40899915ENST00000531252-19124_14449367.0TransmembraneHelical%3B Name%3D3
HgeneNPSR1chr7:34698171chr7:40899915ENST00000531252-19165_18549367.0TransmembraneHelical%3B Name%3D4
HgeneNPSR1chr7:34698171chr7:40899915ENST00000531252-19213_23349367.0TransmembraneHelical%3B Name%3D5
HgeneNPSR1chr7:34698171chr7:40899915ENST00000531252-19276_29649367.0TransmembraneHelical%3B Name%3D6
HgeneNPSR1chr7:34698171chr7:40899915ENST00000531252-19313_33349367.0TransmembraneHelical%3B Name%3D7
HgeneNPSR1chr7:34698171chr7:40899915ENST00000531252-1953_7349367.0TransmembraneHelical%3B Name%3D1
HgeneNPSR1chr7:34698171chr7:40899915ENST00000531252-1983_10349367.0TransmembraneHelical%3B Name%3D2


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Fusion Gene Sequence for NPSR1-C7orf10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>60019_60019_1_NPSR1-C7orf10_NPSR1_chr7_34698171_ENST00000359791_C7orf10_chr7_40899915_ENST00000309930_length(transcript)=718nt_BP=275nt
GGGCTCAGGGAGGGCTCTGTGCCTCCGTTCAGCAGAGCTGCAGCTGCTGCCCAGCTCTCAGGAGGCAAGCTGGACTCCCTCACTCAGCTG
CAGGAGCAAGGACAGTGAGGCTCAACCCCGCCTGAGCCATGCCAGCCAACTTCACAGAGGGCAGCTTCGATTCCAGTGGGACCGGGCAGA
CGCTGGATTCTTCCCCAGTGGCTTGCACTGAAACAGTGACTTTTACTGAAGTGGTGGAAGGAAAGGAATGGGGTTCCTTCTACTACTCCT
TTAAGGCCCAGCTGTGAGATACAGTAAGTTCAAGATGTCAGAGGCCAGGCCGCCCCCGCTGCTCGGGCAGCACACAACGCACATCCTGAA
GGAGGTCCTGAGATACGATGACAGGGCCATCGGGGAGCTGCTCAGCGCTGGAGTGGTGGACCAACATGAAACTCACTGACAAAGGAAAAG
GGCTCTTCCTCATAACCTCGATCCGAATACACTGGCAAAGGCAACACTTTGCTTGGACCCTTCTCCCCAGTTCTGATACCACTAAAAAGA
AGATTTAGAGTAACTCCAGATTTCTTACATGGCATCTCCAGAATGGCTCTGGTATTAATGAATCTAGTGCCTTTTAAATGTATCCCACGT

>60019_60019_1_NPSR1-C7orf10_NPSR1_chr7_34698171_ENST00000359791_C7orf10_chr7_40899915_ENST00000309930_length(amino acids)=73AA_BP=

--------------------------------------------------------------
>60019_60019_2_NPSR1-C7orf10_NPSR1_chr7_34698171_ENST00000360581_C7orf10_chr7_40899915_ENST00000309930_length(transcript)=718nt_BP=275nt
GGGCTCAGGGAGGGCTCTGTGCCTCCGTTCAGCAGAGCTGCAGCTGCTGCCCAGCTCTCAGGAGGCAAGCTGGACTCCCTCACTCAGCTG
CAGGAGCAAGGACAGTGAGGCTCAACCCCGCCTGAGCCATGCCAGCCAACTTCACAGAGGGCAGCTTCGATTCCAGTGGGACCGGGCAGA
CGCTGGATTCTTCCCCAGTGGCTTGCACTGAAACAGTGACTTTTACTGAAGTGGTGGAAGGAAAGGAATGGGGTTCCTTCTACTACTCCT
TTAAGGCCCAGCTGTGAGATACAGTAAGTTCAAGATGTCAGAGGCCAGGCCGCCCCCGCTGCTCGGGCAGCACACAACGCACATCCTGAA
GGAGGTCCTGAGATACGATGACAGGGCCATCGGGGAGCTGCTCAGCGCTGGAGTGGTGGACCAACATGAAACTCACTGACAAAGGAAAAG
GGCTCTTCCTCATAACCTCGATCCGAATACACTGGCAAAGGCAACACTTTGCTTGGACCCTTCTCCCCAGTTCTGATACCACTAAAAAGA
AGATTTAGAGTAACTCCAGATTTCTTACATGGCATCTCCAGAATGGCTCTGGTATTAATGAATCTAGTGCCTTTTAAATGTATCCCACGT

>60019_60019_2_NPSR1-C7orf10_NPSR1_chr7_34698171_ENST00000360581_C7orf10_chr7_40899915_ENST00000309930_length(amino acids)=73AA_BP=

--------------------------------------------------------------
>60019_60019_3_NPSR1-C7orf10_NPSR1_chr7_34698171_ENST00000381539_C7orf10_chr7_40899915_ENST00000309930_length(transcript)=594nt_BP=151nt
AGCCATGCCAGCCAACTTCACAGAGGGCAGCTTCGATTCCAGTGGGACCGGGCAGACGCTGGATTCTTCCCCAGTGGCTTGCACTGAAAC
AGTGACTTTTACTGAAGTGGTGGAAGGAAAGGAATGGGGTTCCTTCTACTACTCCTTTAAGGCCCAGCTGTGAGATACAGTAAGTTCAAG
ATGTCAGAGGCCAGGCCGCCCCCGCTGCTCGGGCAGCACACAACGCACATCCTGAAGGAGGTCCTGAGATACGATGACAGGGCCATCGGG
GAGCTGCTCAGCGCTGGAGTGGTGGACCAACATGAAACTCACTGACAAAGGAAAAGGGCTCTTCCTCATAACCTCGATCCGAATACACTG
GCAAAGGCAACACTTTGCTTGGACCCTTCTCCCCAGTTCTGATACCACTAAAAAGAAGATTTAGAGTAACTCCAGATTTCTTACATGGCA
TCTCCAGAATGGCTCTGGTATTAATGAATCTAGTGCCTTTTAAATGTATCCCACGTTTTGTTCCCTACCATCTTTTTTTTCAGATGATGA

>60019_60019_3_NPSR1-C7orf10_NPSR1_chr7_34698171_ENST00000381539_C7orf10_chr7_40899915_ENST00000309930_length(amino acids)=73AA_BP=

--------------------------------------------------------------
>60019_60019_4_NPSR1-C7orf10_NPSR1_chr7_34698171_ENST00000381542_C7orf10_chr7_40899915_ENST00000309930_length(transcript)=718nt_BP=275nt
GGGCTCAGGGAGGGCTCTGTGCCTCCGTTCAGCAGAGCTGCAGCTGCTGCCCAGCTCTCAGGAGGCAAGCTGGACTCCCTCACTCAGCTG
CAGGAGCAAGGACAGTGAGGCTCAACCCCGCCTGAGCCATGCCAGCCAACTTCACAGAGGGCAGCTTCGATTCCAGTGGGACCGGGCAGA
CGCTGGATTCTTCCCCAGTGGCTTGCACTGAAACAGTGACTTTTACTGAAGTGGTGGAAGGAAAGGAATGGGGTTCCTTCTACTACTCCT
TTAAGGCCCAGCTGTGAGATACAGTAAGTTCAAGATGTCAGAGGCCAGGCCGCCCCCGCTGCTCGGGCAGCACACAACGCACATCCTGAA
GGAGGTCCTGAGATACGATGACAGGGCCATCGGGGAGCTGCTCAGCGCTGGAGTGGTGGACCAACATGAAACTCACTGACAAAGGAAAAG
GGCTCTTCCTCATAACCTCGATCCGAATACACTGGCAAAGGCAACACTTTGCTTGGACCCTTCTCCCCAGTTCTGATACCACTAAAAAGA
AGATTTAGAGTAACTCCAGATTTCTTACATGGCATCTCCAGAATGGCTCTGGTATTAATGAATCTAGTGCCTTTTAAATGTATCCCACGT

>60019_60019_4_NPSR1-C7orf10_NPSR1_chr7_34698171_ENST00000381542_C7orf10_chr7_40899915_ENST00000309930_length(amino acids)=73AA_BP=

--------------------------------------------------------------
>60019_60019_5_NPSR1-C7orf10_NPSR1_chr7_34698171_ENST00000381553_C7orf10_chr7_40899915_ENST00000309930_length(transcript)=764nt_BP=321nt
AGCACGTAGATCCTCCCTGTCATCAGGCAGAGCTCTTCAGTGAGGTGGGCTCAGGGAGGGCTCTGTGCCTCCGTTCAGCAGAGCTGCAGC
TGCTGCCCAGCTCTCAGGAGGCAAGCTGGACTCCCTCACTCAGCTGCAGGAGCAAGGACAGTGAGGCTCAACCCCGCCTGAGCCATGCCA
GCCAACTTCACAGAGGGCAGCTTCGATTCCAGTGGGACCGGGCAGACGCTGGATTCTTCCCCAGTGGCTTGCACTGAAACAGTGACTTTT
ACTGAAGTGGTGGAAGGAAAGGAATGGGGTTCCTTCTACTACTCCTTTAAGGCCCAGCTGTGAGATACAGTAAGTTCAAGATGTCAGAGG
CCAGGCCGCCCCCGCTGCTCGGGCAGCACACAACGCACATCCTGAAGGAGGTCCTGAGATACGATGACAGGGCCATCGGGGAGCTGCTCA
GCGCTGGAGTGGTGGACCAACATGAAACTCACTGACAAAGGAAAAGGGCTCTTCCTCATAACCTCGATCCGAATACACTGGCAAAGGCAA
CACTTTGCTTGGACCCTTCTCCCCAGTTCTGATACCACTAAAAAGAAGATTTAGAGTAACTCCAGATTTCTTACATGGCATCTCCAGAAT
GGCTCTGGTATTAATGAATCTAGTGCCTTTTAAATGTATCCCACGTTTTGTTCCCTACCATCTTTTTTTTCAGATGATGATTTCATTATG

>60019_60019_5_NPSR1-C7orf10_NPSR1_chr7_34698171_ENST00000381553_C7orf10_chr7_40899915_ENST00000309930_length(amino acids)=73AA_BP=

--------------------------------------------------------------
>60019_60019_6_NPSR1-C7orf10_NPSR1_chr7_34698171_ENST00000465305_C7orf10_chr7_40899915_ENST00000309930_length(transcript)=718nt_BP=275nt
GGGCTCAGGGAGGGCTCTGTGCCTCCGTTCAGCAGAGCTGCAGCTGCTGCCCAGCTCTCAGGAGGCAAGCTGGACTCCCTCACTCAGCTG
CAGGAGCAAGGACAGTGAGGCTCAACCCCGCCTGAGCCATGCCAGCCAACTTCACAGAGGGCAGCTTCGATTCCAGTGGGACCGGGCAGA
CGCTGGATTCTTCCCCAGTGGCTTGCACTGAAACAGTGACTTTTACTGAAGTGGTGGAAGGAAAGGAATGGGGTTCCTTCTACTACTCCT
TTAAGGCCCAGCTGTGAGATACAGTAAGTTCAAGATGTCAGAGGCCAGGCCGCCCCCGCTGCTCGGGCAGCACACAACGCACATCCTGAA
GGAGGTCCTGAGATACGATGACAGGGCCATCGGGGAGCTGCTCAGCGCTGGAGTGGTGGACCAACATGAAACTCACTGACAAAGGAAAAG
GGCTCTTCCTCATAACCTCGATCCGAATACACTGGCAAAGGCAACACTTTGCTTGGACCCTTCTCCCCAGTTCTGATACCACTAAAAAGA
AGATTTAGAGTAACTCCAGATTTCTTACATGGCATCTCCAGAATGGCTCTGGTATTAATGAATCTAGTGCCTTTTAAATGTATCCCACGT

>60019_60019_6_NPSR1-C7orf10_NPSR1_chr7_34698171_ENST00000465305_C7orf10_chr7_40899915_ENST00000309930_length(amino acids)=73AA_BP=

--------------------------------------------------------------
>60019_60019_7_NPSR1-C7orf10_NPSR1_chr7_34698171_ENST00000531252_C7orf10_chr7_40899915_ENST00000309930_length(transcript)=718nt_BP=275nt
GGGCTCAGGGAGGGCTCTGTGCCTCCGTTCAGCAGAGCTGCAGCTGCTGCCCAGCTCTCAGGAGGCAAGCTGGACTCCCTCACTCAGCTG
CAGGAGCAAGGACAGTGAGGCTCAACCCCGCCTGAGCCATGCCAGCCAACTTCACAGAGGGCAGCTTCGATTCCAGTGGGACCGGGCAGA
CGCTGGATTCTTCCCCAGTGGCTTGCACTGAAACAGTGACTTTTACTGAAGTGGTGGAAGGAAAGGAATGGGGTTCCTTCTACTACTCCT
TTAAGGCCCAGCTGTGAGATACAGTAAGTTCAAGATGTCAGAGGCCAGGCCGCCCCCGCTGCTCGGGCAGCACACAACGCACATCCTGAA
GGAGGTCCTGAGATACGATGACAGGGCCATCGGGGAGCTGCTCAGCGCTGGAGTGGTGGACCAACATGAAACTCACTGACAAAGGAAAAG
GGCTCTTCCTCATAACCTCGATCCGAATACACTGGCAAAGGCAACACTTTGCTTGGACCCTTCTCCCCAGTTCTGATACCACTAAAAAGA
AGATTTAGAGTAACTCCAGATTTCTTACATGGCATCTCCAGAATGGCTCTGGTATTAATGAATCTAGTGCCTTTTAAATGTATCCCACGT

>60019_60019_7_NPSR1-C7orf10_NPSR1_chr7_34698171_ENST00000531252_C7orf10_chr7_40899915_ENST00000309930_length(amino acids)=73AA_BP=

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NPSR1-C7orf10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NPSR1-C7orf10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NPSR1-C7orf10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource