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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NQO1-DYRK1A (FusionGDB2 ID:60053)

Fusion Gene Summary for NQO1-DYRK1A

check button Fusion gene summary
Fusion gene informationFusion gene name: NQO1-DYRK1A
Fusion gene ID: 60053
HgeneTgene
Gene symbol

NQO1

DYRK1A

Gene ID

1728

1859

Gene nameNAD(P)H quinone dehydrogenase 1dual specificity tyrosine phosphorylation regulated kinase 1A
SynonymsDHQU|DIA4|DTD|NMOR1|NMORI|QR1DYRK|DYRK1|HP86|MNB|MNBH|MRD7
Cytomap

16q22.1

21q22.13

Type of geneprotein-codingprotein-coding
DescriptionNAD(P)H dehydrogenase [quinone] 1DT-diaphoraseNAD(P)H dehydrogenase, quinone 1NAD(P)H:Quinone acceptor oxidoreductase type 1NAD(P)H:menadione oxidoreductase 1NAD(P)H:quinone oxidoreductase 1NAD(P)H:quinone oxireductaseazoreductasediaphorase (NADH/dual specificity tyrosine-phosphorylation-regulated kinase 1AMNB/DYRK protein kinasedual specificity YAK1-related kinasedual specificity tyrosine-(Y)-phosphorylation regulated kinase 1Amnb protein kinase homolog hp86protein kinase minibrain homologs
Modification date2020032920200315
UniProtAcc

P15559

Q13627

Ensembl transtripts involved in fusion geneENST00000320623, ENST00000379046, 
ENST00000379047, ENST00000439109, 
ENST00000561500, ENST00000564043, 
ENST00000338785, ENST00000339659, 
ENST00000321219, ENST00000398956, 
ENST00000398960, ENST00000451934, 
ENST00000455387, ENST00000462274, 
Fusion gene scores* DoF score12 X 11 X 5=66011 X 9 X 4=396
# samples 1311
** MAII scorelog2(13/660*10)=-2.34395440121736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/396*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NQO1 [Title/Abstract] AND DYRK1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNQO1(69744922)-DYRK1A(38887379), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDYRK1A

GO:0018108

peptidyl-tyrosine phosphorylation

9748265

TgeneDYRK1A

GO:0033120

positive regulation of RNA splicing

28377597

TgeneDYRK1A

GO:0038083

peptidyl-tyrosine autophosphorylation

24327345


check buttonFusion gene breakpoints across NQO1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DYRK1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABM983726NQO1chr16

69744922

+DYRK1Achr21

38887379

+


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Fusion Gene ORF analysis for NQO1-DYRK1A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000320623ENST00000338785NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-3UTRENST00000320623ENST00000339659NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-3UTRENST00000379046ENST00000338785NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-3UTRENST00000379046ENST00000339659NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-3UTRENST00000379047ENST00000338785NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-3UTRENST00000379047ENST00000339659NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-3UTRENST00000439109ENST00000338785NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-3UTRENST00000439109ENST00000339659NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-3UTRENST00000561500ENST00000338785NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-3UTRENST00000561500ENST00000339659NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-3UTRENST00000564043ENST00000338785NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-3UTRENST00000564043ENST00000339659NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000320623ENST00000321219NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000320623ENST00000398956NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000320623ENST00000398960NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000320623ENST00000451934NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000320623ENST00000455387NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000320623ENST00000462274NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000379046ENST00000321219NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000379046ENST00000398956NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000379046ENST00000398960NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000379046ENST00000451934NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000379046ENST00000455387NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000379046ENST00000462274NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000379047ENST00000321219NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000379047ENST00000398956NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000379047ENST00000398960NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000379047ENST00000451934NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000379047ENST00000455387NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000379047ENST00000462274NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000439109ENST00000321219NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000439109ENST00000398956NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000439109ENST00000398960NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000439109ENST00000451934NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000439109ENST00000455387NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000439109ENST00000462274NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000561500ENST00000321219NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000561500ENST00000398956NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000561500ENST00000398960NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000561500ENST00000451934NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000561500ENST00000455387NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000561500ENST00000462274NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000564043ENST00000321219NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000564043ENST00000398956NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000564043ENST00000398960NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000564043ENST00000451934NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000564043ENST00000455387NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000564043ENST00000462274NQO1chr16

69744922

+DYRK1Achr21

38887379

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NQO1-DYRK1A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NQO1-DYRK1A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:69744922/:38887379)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NQO1

P15559

DYRK1A

Q13627

FUNCTION: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.FUNCTION: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity). {ECO:0000250|UniProtKB:Q61214, ECO:0000250|UniProtKB:Q9NR20, ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067, ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:8769099}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NQO1-DYRK1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NQO1-DYRK1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NQO1-DYRK1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NQO1-DYRK1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource