FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:NR2F2-RPS20 (FusionGDB2 ID:60146)

Fusion Gene Summary for NR2F2-RPS20

check button Fusion gene summary
Fusion gene informationFusion gene name: NR2F2-RPS20
Fusion gene ID: 60146
HgeneTgene
Gene symbol

NR2F2

RPS20

Gene ID

7026

6224

Gene namenuclear receptor subfamily 2 group F member 2ribosomal protein S20
SynonymsARP-1|ARP1|CHTD4|COUPTF2|COUPTFB|COUPTFII|NF-E3|SVP40|TFCOUP2S20|uS10
Cytomap

15q26.2

8q12.1

Type of geneprotein-codingprotein-coding
DescriptionCOUP transcription factor 2ADP-ribosylation factor related protein 1COUP transcription factor IIapolipoprotein A-I regulatory protein 1apolipoprotein AI regulatory protein 1chicken ovalbumin upstream promoter transcription factor 2chicken ovalbumin 40S ribosomal protein S20small ribosomal subunit protein uS10
Modification date2020031320200327
UniProtAcc

P24468

.
Ensembl transtripts involved in fusion geneENST00000394166, ENST00000394171, 
ENST00000421109, ENST00000453270, 
ENST00000009589, ENST00000524349, 
ENST00000518875, ENST00000519606, 
ENST00000519807, ENST00000520490, 
ENST00000520627, ENST00000521262, 
ENST00000523936, 
Fusion gene scores* DoF score12 X 9 X 4=43221 X 12 X 3=756
# samples 1322
** MAII scorelog2(13/432*10)=-1.73251968913501
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/756*10)=-1.78088271069641
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NR2F2 [Title/Abstract] AND RPS20 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNR2F2(96872312)-RPS20(56985613), # samples:3
RPS20(56985613)-NR2F2(96872312), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNR2F2

GO:0000122

negative regulation of transcription by RNA polymerase II

9343308

HgeneNR2F2

GO:0045736

negative regulation of cyclin-dependent protein serine/threonine kinase activity

19210544

HgeneNR2F2

GO:0045892

negative regulation of transcription, DNA-templated

19210544

HgeneNR2F2

GO:0045893

positive regulation of transcription, DNA-templated

18798693


check buttonFusion gene breakpoints across NR2F2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RPS20 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA079014NR2F2chr15

96872312

+RPS20chr8

56985613

+
ChiTaRS5.0N/ABI496781NR2F2chr15

96872312

+RPS20chr8

56985613

+
ChiTaRS5.0N/ABI496850NR2F2chr15

96872312

+RPS20chr8

56985613

+


Top

Fusion Gene ORF analysis for NR2F2-RPS20

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000394166ENST00000009589NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-3UTRENST00000394166ENST00000524349NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-3UTRENST00000394171ENST00000009589NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-3UTRENST00000394171ENST00000524349NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-3UTRENST00000421109ENST00000009589NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-3UTRENST00000421109ENST00000524349NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-3UTRENST00000453270ENST00000009589NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-3UTRENST00000453270ENST00000524349NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000394166ENST00000518875NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000394166ENST00000519606NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000394166ENST00000519807NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000394166ENST00000520490NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000394166ENST00000520627NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000394166ENST00000521262NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000394166ENST00000523936NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000394171ENST00000518875NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000394171ENST00000519606NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000394171ENST00000519807NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000394171ENST00000520490NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000394171ENST00000520627NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000394171ENST00000521262NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000394171ENST00000523936NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000421109ENST00000518875NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000421109ENST00000519606NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000421109ENST00000519807NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000421109ENST00000520490NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000421109ENST00000520627NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000421109ENST00000521262NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000421109ENST00000523936NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000453270ENST00000518875NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000453270ENST00000519606NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000453270ENST00000519807NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000453270ENST00000520490NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000453270ENST00000520627NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000453270ENST00000521262NR2F2chr15

96872312

+RPS20chr8

56985613

+
intron-intronENST00000453270ENST00000523936NR2F2chr15

96872312

+RPS20chr8

56985613

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for NR2F2-RPS20


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for NR2F2-RPS20


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:96872312/:56985613)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NR2F2

P24468

.
FUNCTION: Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. May be required to establish ovary identity during early gonad development (PubMed:29478779). {ECO:0000269|PubMed:18798693, ECO:0000269|PubMed:1899293, ECO:0000269|PubMed:29478779, ECO:0000269|PubMed:9343308}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for NR2F2-RPS20


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for NR2F2-RPS20


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for NR2F2-RPS20


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for NR2F2-RPS20


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource