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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NR4A1-IL20RB (FusionGDB2 ID:60171)

Fusion Gene Summary for NR4A1-IL20RB

check button Fusion gene summary
Fusion gene informationFusion gene name: NR4A1-IL20RB
Fusion gene ID: 60171
HgeneTgene
Gene symbol

NR4A1

IL20RB

Gene ID

3164

53833

Gene namenuclear receptor subfamily 4 group A member 1interleukin 20 receptor subunit beta
SynonymsGFRP1|HMR|N10|NAK-1|NGFIB|NP10|NUR77|TR3DIRS1|FNDC6|IL-20R2
Cytomap

12q13.13

3q22.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor subfamily 4 group A member 1ST-59TR3 orphan receptorearly response protein NAK1growth factor-inducible nuclear protein N10hormone receptornerve growth factor IB nuclear receptor variant 1nuclear hormone receptor NUR/77orphan nucleinterleukin-20 receptor subunit betaIL-20 receptor subunit betaIL-20R-betaIL-20RBfibronectin type III domain containing 6interleukin 20 receptor beta subunitinterleukin-20 receptor II
Modification date2020032920200313
UniProtAcc

P22736

Q6UXL0

Ensembl transtripts involved in fusion geneENST00000360284, ENST00000545748, 
ENST00000550082, ENST00000243050, 
ENST00000394824, ENST00000394825, 
ENST00000547206, ENST00000548232, 
ENST00000309741, ENST00000329582, 
ENST00000484501, 
Fusion gene scores* DoF score7 X 8 X 3=1686 X 6 X 7=252
# samples 915
** MAII scorelog2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/252*10)=-0.748461233004036
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NR4A1 [Title/Abstract] AND IL20RB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIL20RB(136677043)-NR4A1(52448111), # samples:1
NR4A1(52435713)-IL20RB(136699308), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNR4A1

GO:0002042

cell migration involved in sprouting angiogenesis

18059339

HgeneNR4A1

GO:0045944

positive regulation of transcription by RNA polymerase II

22427340


check buttonFusion gene breakpoints across NR4A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across IL20RB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-BA-6871-01ANR4A1chr12

52435713

-IL20RBchr3

136699308

+
ChimerDB4HNSCTCGA-BA-6871-01ANR4A1chr12

52435713

+IL20RBchr3

136699308

+
ChimerDB4HNSCTCGA-BA-6871NR4A1chr12

52435713

+IL20RBchr3

136699307

+
ChimerDB4HNSCTCGA-BA-6871NR4A1chr12

52435713

+IL20RBchr3

136699308

+


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Fusion Gene ORF analysis for NR4A1-IL20RB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000360284ENST00000309741NR4A1chr12

52435713

+IL20RBchr3

136699308

+
5CDS-5UTRENST00000360284ENST00000309741NR4A1chr12

52435713

+IL20RBchr3

136699307

+
5CDS-5UTRENST00000545748ENST00000309741NR4A1chr12

52435713

+IL20RBchr3

136699308

+
5CDS-5UTRENST00000545748ENST00000309741NR4A1chr12

52435713

+IL20RBchr3

136699307

+
5CDS-5UTRENST00000550082ENST00000309741NR4A1chr12

52435713

+IL20RBchr3

136699308

+
5CDS-5UTRENST00000550082ENST00000309741NR4A1chr12

52435713

+IL20RBchr3

136699307

+
5CDS-intronENST00000360284ENST00000329582NR4A1chr12

52435713

+IL20RBchr3

136699308

+
5CDS-intronENST00000360284ENST00000329582NR4A1chr12

52435713

+IL20RBchr3

136699307

+
5CDS-intronENST00000360284ENST00000484501NR4A1chr12

52435713

+IL20RBchr3

136699308

+
5CDS-intronENST00000360284ENST00000484501NR4A1chr12

52435713

+IL20RBchr3

136699307

+
5CDS-intronENST00000545748ENST00000329582NR4A1chr12

52435713

+IL20RBchr3

136699308

+
5CDS-intronENST00000545748ENST00000329582NR4A1chr12

52435713

+IL20RBchr3

136699307

+
5CDS-intronENST00000545748ENST00000484501NR4A1chr12

52435713

+IL20RBchr3

136699308

+
5CDS-intronENST00000545748ENST00000484501NR4A1chr12

52435713

+IL20RBchr3

136699307

+
5CDS-intronENST00000550082ENST00000329582NR4A1chr12

52435713

+IL20RBchr3

136699308

+
5CDS-intronENST00000550082ENST00000329582NR4A1chr12

52435713

+IL20RBchr3

136699307

+
5CDS-intronENST00000550082ENST00000484501NR4A1chr12

52435713

+IL20RBchr3

136699308

+
5CDS-intronENST00000550082ENST00000484501NR4A1chr12

52435713

+IL20RBchr3

136699307

+
intron-5UTRENST00000243050ENST00000309741NR4A1chr12

52435713

+IL20RBchr3

136699308

+
intron-5UTRENST00000243050ENST00000309741NR4A1chr12

52435713

+IL20RBchr3

136699307

+
intron-5UTRENST00000394824ENST00000309741NR4A1chr12

52435713

+IL20RBchr3

136699308

+
intron-5UTRENST00000394824ENST00000309741NR4A1chr12

52435713

+IL20RBchr3

136699307

+
intron-5UTRENST00000394825ENST00000309741NR4A1chr12

52435713

+IL20RBchr3

136699308

+
intron-5UTRENST00000394825ENST00000309741NR4A1chr12

52435713

+IL20RBchr3

136699307

+
intron-5UTRENST00000547206ENST00000309741NR4A1chr12

52435713

+IL20RBchr3

136699308

+
intron-5UTRENST00000547206ENST00000309741NR4A1chr12

52435713

+IL20RBchr3

136699307

+
intron-5UTRENST00000548232ENST00000309741NR4A1chr12

52435713

+IL20RBchr3

136699308

+
intron-5UTRENST00000548232ENST00000309741NR4A1chr12

52435713

+IL20RBchr3

136699307

+
intron-intronENST00000243050ENST00000329582NR4A1chr12

52435713

+IL20RBchr3

136699308

+
intron-intronENST00000243050ENST00000329582NR4A1chr12

52435713

+IL20RBchr3

136699307

+
intron-intronENST00000243050ENST00000484501NR4A1chr12

52435713

+IL20RBchr3

136699308

+
intron-intronENST00000243050ENST00000484501NR4A1chr12

52435713

+IL20RBchr3

136699307

+
intron-intronENST00000394824ENST00000329582NR4A1chr12

52435713

+IL20RBchr3

136699308

+
intron-intronENST00000394824ENST00000329582NR4A1chr12

52435713

+IL20RBchr3

136699307

+
intron-intronENST00000394824ENST00000484501NR4A1chr12

52435713

+IL20RBchr3

136699308

+
intron-intronENST00000394824ENST00000484501NR4A1chr12

52435713

+IL20RBchr3

136699307

+
intron-intronENST00000394825ENST00000329582NR4A1chr12

52435713

+IL20RBchr3

136699308

+
intron-intronENST00000394825ENST00000329582NR4A1chr12

52435713

+IL20RBchr3

136699307

+
intron-intronENST00000394825ENST00000484501NR4A1chr12

52435713

+IL20RBchr3

136699308

+
intron-intronENST00000394825ENST00000484501NR4A1chr12

52435713

+IL20RBchr3

136699307

+
intron-intronENST00000547206ENST00000329582NR4A1chr12

52435713

+IL20RBchr3

136699308

+
intron-intronENST00000547206ENST00000329582NR4A1chr12

52435713

+IL20RBchr3

136699307

+
intron-intronENST00000547206ENST00000484501NR4A1chr12

52435713

+IL20RBchr3

136699308

+
intron-intronENST00000547206ENST00000484501NR4A1chr12

52435713

+IL20RBchr3

136699307

+
intron-intronENST00000548232ENST00000329582NR4A1chr12

52435713

+IL20RBchr3

136699308

+
intron-intronENST00000548232ENST00000329582NR4A1chr12

52435713

+IL20RBchr3

136699307

+
intron-intronENST00000548232ENST00000484501NR4A1chr12

52435713

+IL20RBchr3

136699308

+
intron-intronENST00000548232ENST00000484501NR4A1chr12

52435713

+IL20RBchr3

136699307

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NR4A1-IL20RB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NR4A1chr1252435713+IL20RBchr3136699307+0.000362050.99963796
NR4A1chr1252435713+IL20RBchr3136699307+0.000362050.99963796
NR4A1chr1252435713+IL20RBchr3136699307+0.000362050.99963796
NR4A1chr1252435713+IL20RBchr3136699307+0.000362050.99963796

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NR4A1-IL20RB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:136677043/:52448111)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NR4A1

P22736

IL20RB

Q6UXL0

FUNCTION: Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P12813, ECO:0000269|PubMed:15466594, ECO:0000269|PubMed:22983157}.FUNCTION: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NR4A1-IL20RB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NR4A1-IL20RB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NR4A1-IL20RB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NR4A1-IL20RB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource